Detailed information for compound 557845

Basic information

Technical information
  • TDR Targets ID: 557845
  • Name: methyl (9Z,12Z,15Z)-octadeca-9,12,15-trienoat e
  • MW: 292.456 | Formula: C19H32O2
  • H donors: 0 H acceptors: 1 LogP: 6.22 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)OC
  • InChi: 1S/C19H32O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21-2/h4-5,7-8,10-11H,3,6,9,12-18H2,1-2H3/b5-4-,8-7-,11-10-
  • InChiKey: DVWSXZIHSUZZKJ-YSTUJMKBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid methyl ester
  • methyl linolenate
  • 301-00-8
  • Methyl cis,cis,cis-octadec-9,12,15-trienoate
  • NSC 607759
  • alpha-Linolenic acid methyl ester
  • 62200_FLUKA
  • 62210_FLUKA
  • Methyl cis,cis,cis-9,12,15-octadecatrienoate
  • Methyllinolenate
  • L2626_SIGMA
  • 9,12,15-Octadecatrienoic acid, methyl ester, (9Z,12Z,15Z)-
  • 9,12,15-Octadecatrienoic acid, methyl ester, (Z,Z,Z)-
  • AI3-26935
  • EINECS 206-102-3
  • Linolenic acid, methyl ester
  • Methyl (9Z,12Z,15Z)-9,12,15-octadecatrienoate
  • Methyl all-cis-9,12,15-octadecatrienoate
  • Methyl alpha-linolenate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii thioredoxin reductase 0.0037 0.0408 0.0806
Trypanosoma cruzi Heat shock protein 83, putative 0.0044 0.0525 0.1107
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0428 0.7976
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.008 0.0111
Trypanosoma brucei Peptide deformylase 2 0.0083 0.1112 0.2457
Mycobacterium tuberculosis Probable gamma-glutamyl phosphate reductase protein ProA (GPR) (glutamate-5-semialdehyde dehydrogenase) (glutamyl-gamma-semialde 0.0017 0.011 0.0147
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.011 0.2102
Toxoplasma gondii aldehyde dehydrogenase (NAD) family protein 0.0017 0.011 0.0147
Echinococcus multilocularis pyruvate kinase 0.0017 0.0103 0.0103
Echinococcus multilocularis pyruvate kinase 0.0026 0.0239 0.0239
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0149 0.0149
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0433 0.1293
Onchocerca volvulus 0.0038 0.0433 0.0784
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0397 0.1134
Brugia malayi ecdysteroid receptor 0.002 0.0149 0.0208
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.439 1
Brugia malayi hypothetical protein 0.001 0.0009 0.0012
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0017 0.011 0.011
Mycobacterium tuberculosis Conserved protein 0.0038 0.0433 0.0861
Loa Loa (eye worm) endoplasmin 0.0044 0.0525 0.0731
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2922 0.4067
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0101 0.1375 0.1375
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0342 0.0957
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0218 0.3155 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0342 0.0476
Loa Loa (eye worm) hypothetical protein 0.0148 0.2101 0.2924
Brugia malayi beta-lactamase 0.0038 0.0433 0.0602
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0015 0.008 0.0111
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0408 0.0806
Echinococcus granulosus cpg binding protein 0.0032 0.0339 0.0339
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0044 0.0044
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.439 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0149 0.0208
Schistosoma mansoni nuclear hormone receptor 0.002 0.0149 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0149 0.0149
Schistosoma mansoni tar DNA-binding protein 0.0062 0.079 0.079
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0408 0.1169
Mycobacterium ulcerans bifunctional acetaldehyde-CoA/alcohol dehydrogenase 0.0017 0.011 0.0147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.049 0.1025
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.011 0.011
Brugia malayi CXXC zinc finger family protein 0.003 0.0313 0.0436
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0417 0.0826
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.1085 0.1511
Plasmodium vivax heat shock protein 86, putative 0.0044 0.0525 0.1546
Schistosoma mansoni microtubule-associated protein tau 0.067 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0149 0.0208
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1121 0.2385
Loa Loa (eye worm) ACC-1 protein 0.0015 0.008 0.0111
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1121 0.2385
Loa Loa (eye worm) hypothetical protein 0.0101 0.1375 0.1914
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1999 0.4333
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0015 0.008 0.008
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0017 0.011 0.02
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1121 0.2385
Loa Loa (eye worm) hypothetical protein 0.0035 0.038 0.0529
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.1085 0.1085
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.011 0.0147
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0433 0.0861
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.008 0.0111
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0342 0.066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0096 0.0096
Brugia malayi Inositol-1 0.0036 0.0397 0.0553
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0149 0.0149
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0397 0.0782
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0154
Echinococcus granulosus pyruvate kinase 0.0032 0.0342 0.0342
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0149 0.0271
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0428 0.0883
Schistosoma mansoni pyruvate kinase 0.0017 0.0103 0.0103
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0149 0.0208
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Loa Loa (eye worm) hypothetical protein 0.0038 0.0433 0.0602
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.2242 0.487
Brugia malayi hypothetical protein 0.0035 0.0381 0.053
Trichomonas vaginalis set domain proteins, putative 0.0231 0.3345 1
Schistosoma mansoni hypothetical protein 0.0099 0.1347 0.1347
Trypanosoma cruzi heat shock protein 90, putative 0.0019 0.0134 0.0206
Loa Loa (eye worm) heat shock protein 75 0.003 0.0299 0.0416
Mycobacterium ulcerans lipase LipD 0.0038 0.0433 0.0861
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0433 0.0433
Trichomonas vaginalis esterase, putative 0.0038 0.0433 0.1293
Mycobacterium tuberculosis Probable pyrroline-5-carboxylate dehydrogenase RocA 0.0017 0.011 0.0147
Toxoplasma gondii heat shock protein HSP90 0.0044 0.0525 0.1066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0149 0.0208
Schistosoma mansoni hypothetical protein 0.0081 0.1085 0.1085
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0149 0.0149
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.1085 0.1085
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.079 0.1099
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, GabD1 0.0017 0.011 0.0147
Onchocerca volvulus 0.0015 0.008 0.0144
Leishmania major heat shock protein, putative 0.003 0.0299 0.0565
Schistosoma mansoni tar DNA-binding protein 0.0062 0.079 0.079
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0525 0.1107
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0009 0.0012
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0525 0.1107
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0417 0.1247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0301 0.0301
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0433 0.0861
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Echinococcus granulosus heat shock protein 90 0.0038 0.0428 0.0428
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.003 0.0299 0.0542
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0342 0.0476
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Brugia malayi nuclear receptor NHR-88 0.002 0.0149 0.0208
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0313 0.0436
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0149 0.0208
Giardia lamblia Alcohol dehydrogenase 0.0017 0.011 0.1375
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0433 0.1248
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Toxoplasma gondii aldehyde dehydrogenase 0.0311 0.4557 1
Entamoeba histolytica hypothetical protein 0.0035 0.0381 0.7245
Toxoplasma gondii gamma-glutamyl phosphate reductase, putative 0.0017 0.011 0.0147
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0397 0.0782
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0149 0.0208
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0194 0.027
Trypanosoma cruzi Peptide deformylase 2, putative 0.0083 0.1112 0.2457
Schistosoma mansoni hypothetical protein 0.0081 0.1085 0.1085
Brugia malayi Cation transporter family protein 0.0015 0.008 0.0111
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0397 0.0397
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0042 0.0484 0.0974
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0015 0.008 0.008
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.3308 0.3308
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0015 0.008 0.008
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0342 0.0476
Brugia malayi MH2 domain containing protein 0.0118 0.1645 0.229
Leishmania major hypothetical protein, conserved 0.0038 0.0433 0.0861
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0342 0.0476
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0525 0.1107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0012
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Schistosoma mansoni pyruvate kinase 0.0032 0.0342 0.0342
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.008 0.0111
Schistosoma mansoni hypothetical protein 0.0017 0.011 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0311 0.4557 1
Mycobacterium leprae Probable lipase LipE 0.0038 0.0433 0.1058
Leishmania major pyruvate kinase 0.0032 0.0342 0.066
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0149 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0062 0.079 0.079
Echinococcus multilocularis pyruvate kinase 0.0032 0.0342 0.0342
Brugia malayi TAR-binding protein 0.0062 0.079 0.1099
Plasmodium falciparum heat shock protein 90, putative 0.0026 0.0243 0.0639
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.008 0.008
Toxoplasma gondii NADP-dependent succinate-semialdehyde dehydrogenase 0.0017 0.011 0.0147
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1121 0.2385
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0417 0.0417
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.011 0.0152
Echinococcus multilocularis heat shock protein 90 0.0038 0.0428 0.0428
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0433 0.0861
Schistosoma mansoni hypothetical protein 0.0531 0.7892 0.7892
Plasmodium vivax SET domain protein, putative 0.003 0.0301 0.0824
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0417 0.0826
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0017 0.011 0.011
Brugia malayi hypothetical protein 0.0374 0.552 0.7683
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0062 0.079 0.079
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Echinococcus multilocularis tar DNA binding protein 0.0062 0.079 0.079
Echinococcus granulosus heat shock protein 0.0044 0.0525 0.0525
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Schistosoma mansoni ap endonuclease 0.0037 0.0417 0.0417
Loa Loa (eye worm) hypothetical protein 0.0374 0.552 0.7683
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0397 0.1187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0433 0.0602
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0274 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0149 0.0208
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0012
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0083 0.1112 0.2457
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1347 0.1875
Brugia malayi Cation transporter family protein 0.0101 0.1375 0.1914
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0397 0.0812
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.008 0.008
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0228 0.3308 0.4604
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0433 0.0861
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0149 0.0208
Plasmodium vivax glutathione reductase, putative 0.0037 0.0408 0.1169
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0103 0.019
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0397 0.1187
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0044 0.0132
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.003 0.0299 0.0299
Mycobacterium tuberculosis Possible succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD2 0.0017 0.011 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0149 0.0208
Schistosoma mansoni survival motor neuron protein 0.0099 0.1347 0.1347
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.003 0.0299 0.0299
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0525 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Schistosoma mansoni cpg binding protein 0.0032 0.0339 0.0339
Trypanosoma brucei aldehyde dehydrogenase family, putative 0.0017 0.011 0.0152
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0418
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1645 0.229
Onchocerca volvulus 0.003 0.0313 0.0567
Leishmania major pyrroline-5-carboxylate synthetase-like protein 0.0017 0.011 0.0147
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0015 0.008 0.008
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0015 0.008 0.008
Treponema pallidum polypeptide deformylase (def) 0.0218 0.3155 1
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.011 0.0152
Mycobacterium ulcerans pyrroline-5-carboxylate dehydrogenase, RocA 0.0017 0.011 0.0147
Loa Loa (eye worm) heat shock protein 90 0.0044 0.0525 0.0731
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0301 0.0301
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0044 0.0044
Echinococcus multilocularis geminin 0.0531 0.7892 0.7892
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Schistosoma mansoni hypothetical protein 0.0531 0.7892 0.7892
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.1085 0.1085
Onchocerca volvulus 0.0038 0.0433 0.0784
Plasmodium vivax heat shock protein, putative 0.0169 0.2405 0.759
Trichomonas vaginalis heat shock protein, putative 0.0044 0.0525 0.1571
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0012
Onchocerca volvulus 0.0038 0.0433 0.0784
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0149 0.0149
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0433 0.0433
Mycobacterium ulcerans peptide deformylase 0.0218 0.3155 0.6894
Loa Loa (eye worm) hypothetical protein 0.0081 0.1085 0.1511
Plasmodium falciparum thioredoxin reductase 0.0037 0.0408 0.1169
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0417 0.058
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0149 0.0149
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.008 0.008
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Echinococcus multilocularis heat shock protein 0.0044 0.0525 0.0525
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0149 0.0208
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0017 0.011 0.011
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0042 0.0484 0.1413
Trypanosoma brucei aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0397 0.1187
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Brugia malayi Cation transporter family protein 0.0015 0.008 0.0111
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.011 0.0152
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0415 0.0415
Schistosoma mansoni inositol monophosphatase 0.0036 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0433 0.0602
Loa Loa (eye worm) beta-lactamase 0.0038 0.0433 0.0602
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0397 0.0812
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0015 0.008 0.0111
Trypanosoma brucei Polypeptide deformylase 1 0.0083 0.1112 0.2457
Entamoeba histolytica heat shock protein 90, putative 0.0044 0.0525 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0301 0.0301
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0149 0.0208
Schistosoma mansoni endoplasmin 0.0044 0.0525 0.0525
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0149 0.0149
Echinococcus multilocularis nAChR subunit 0.0015 0.008 0.008
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.034 0.0753
Brugia malayi glutathione reductase 0.0037 0.0408 0.0568
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0009 0.0009
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Brugia malayi RNA binding protein 0.0062 0.079 0.1099
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0017 0.011 0.011
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0433 0.0861
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.0015
Onchocerca volvulus 0.002 0.0149 0.0271
Plasmodium falciparum glutathione reductase 0.0037 0.0408 0.1169
Echinococcus granulosus pyruvate kinase 0.0017 0.0103 0.0103
Echinococcus multilocularis pyruvate kinase 0.0017 0.0103 0.0103
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0408 0.0568
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0016 0.0096 0.0134
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0083 0.1112 0.2457
Loa Loa (eye worm) RNA binding protein 0.0062 0.079 0.1099
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1121 0.2385
Loa Loa (eye worm) hypothetical protein 0.0023 0.0194 0.027
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1121 0.3317
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0096 0.0096
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1262 0.2699
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0009 0.0009
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0042 0.0484 0.1227
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0015 0.008 0.0111
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0149 0.0208
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0484 0.1447
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.1999 0.4499
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0311 0.4557 0.4557
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.011 0.0147
Brugia malayi excitatory GABA receptor EXP-1A 0.0015 0.008 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Echinococcus multilocularis muscleblind protein 1 0.0148 0.2101 0.2101
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0433 0.0861
Brugia malayi nuclear hormone receptor 0.002 0.0149 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0301 0.0301
Echinococcus granulosus pyruvate kinase 0.0017 0.0103 0.0103
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0017 0.011 0.0147
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0017 0.011 0.011
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.011 0.0147
Giardia lamblia Pyruvate kinase 0.0017 0.0103 0.1227
Plasmodium falciparum peptide deformylase 0.0218 0.3155 1
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0149 0.0271
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0417 0.058
Loa Loa (eye worm) hypothetical protein 0.0051 0.0625 0.087
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Schistosoma mansoni endoplasmin 0.0044 0.0525 0.0525
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.011 0.011
Trypanosoma brucei trypanothione reductase 0.0037 0.0408 0.0837
Brugia malayi aldehyde dehydrogenase 0.0017 0.011 0.0154
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.3308 0.3308
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0417 0.7938
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0149 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0149 0.0208
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.1085 0.1085
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.008 0.008
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0015 0.008 0.0111
Mycobacterium ulcerans beta-lactamase 0.0038 0.0433 0.0861
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0417 0.0417
Toxoplasma gondii hypothetical protein 0.0048 0.0584 0.1195
Onchocerca volvulus 0.0015 0.008 0.0144
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0015 0.008 0.0111
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Onchocerca volvulus 0.0099 0.1347 0.2441
Schistosoma mansoni aldehyde dehydrogenase 0.0311 0.4557 0.4557
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.011 0.011
Loa Loa (eye worm) glutathione reductase 0.0037 0.0408 0.0568
Echinococcus granulosus muscleblind protein 0.0148 0.2101 0.2101
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0342 0.1023
Brugia malayi Pre-SET motif family protein 0.0203 0.2922 0.4067
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0044 0.0044
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0342 0.062
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0015 0.008 0.008
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0342 0.0685
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0015 0.008 0.008
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.008 0.008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0096 0.0096
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0311 0.4557 1
Onchocerca volvulus 0.003 0.0301 0.0545
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.1085 0.1085
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0017 0.011 0.011
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0012
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0015 0.008 0.008
Loa Loa (eye worm) aldehyde dehydrogenase 0.0017 0.011 0.0154
Echinococcus multilocularis survival motor neuron protein 1 0.0484 0.7185 0.7185
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Mycobacterium ulcerans gamma-aminobutyraldehyde dehydrogenase 0.0017 0.011 0.0147
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.008 0.0111
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0149 0.0149
Loa Loa (eye worm) ACC-1 protein 0.0015 0.008 0.0111
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0096 0.0134
Echinococcus granulosus survival motor neuron protein 1 0.0484 0.7185 0.7185
Echinococcus granulosus endoplasmin 0.0042 0.0484 0.0484
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0417 0.1198
Mycobacterium ulcerans heat shock protein 90 0.0042 0.0484 0.0974
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.049 0.1025
Schistosoma mansoni tar DNA-binding protein 0.0062 0.079 0.079
Trichomonas vaginalis succinate semialdehyde dehydrogenase, putative 0.0017 0.011 0.033
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0433 0.1293
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0017 0.011 0.0154
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0149 0.0149
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0342 0.0476
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.3564 0.7801
Toxoplasma gondii hypothetical protein 0.0218 0.3155 0.6894
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0015 0.008 0.0111
Toxoplasma gondii heat shock protein 75, putative 0.003 0.0299 0.0565
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1262 0.3782
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0017 0.011 0.011
Schistosoma mansoni cpg binding protein 0.003 0.0313 0.0313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0433 0.0602
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0381 0.0381
Mycobacterium ulcerans aldehyde dehydrogenase (NAD+) dependent 0.0017 0.011 0.0147
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0012
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0015 0.008 0.0111
Toxoplasma gondii methylmalonate-semialdehyde dehydrogenase [acylating], putative 0.0017 0.011 0.0147
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0417 0.1198
Leishmania major pyruvate kinase 0.0032 0.0342 0.066
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0044 0.0132
Echinococcus granulosus pyruvate kinase 0.0032 0.0342 0.0342
Trypanosoma cruzi heat shock protein, putative 0.003 0.0299 0.0587
Onchocerca volvulus 0.0101 0.1375 0.2492
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0096 0.0134
Trypanosoma brucei delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.011 0.0152
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.011 0.011
Brugia malayi beta-lactamase family protein 0.0038 0.0433 0.0602
Loa Loa (eye worm) hypothetical protein 0.0484 0.7185 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0149 0.0149
Echinococcus granulosus glycine receptor subunit beta 0.0015 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0149 0.0208
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0009 0.0009
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0103 0.019
Schistosoma mansoni heat shock protein 0.003 0.0299 0.0299
Mycobacterium tuberculosis Probable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH) 0.0017 0.011 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0381 0.0381
Trypanosoma brucei heat shock protein, putative 0.0044 0.0525 0.1107
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0149 0.0149
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0149 0.0149
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0625 0.087
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Echinococcus multilocularis endoplasmin 0.0042 0.0484 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0149 0.0208
Onchocerca volvulus Huntingtin homolog 0.0374 0.552 1
Plasmodium falciparum heat shock protein 90 0.0044 0.0525 0.1546
Schistosoma mansoni hypothetical protein 0.0081 0.1085 0.1085
Mycobacterium ulcerans aldehyde dehydrogenase 0.0017 0.011 0.0147
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0017 0.011 0.0154
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0342 0.0685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0149 0.0149
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0228 0.3308 0.4604
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0149 0.0149
Schistosoma mansoni thyroid hormone receptor 0.002 0.0149 0.0149
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.008 0.008
Giardia lamblia Pyruvate kinase 0.0032 0.0342 0.619
Entamoeba histolytica hypothetical protein 0.0035 0.0381 0.7245
Trypanosoma cruzi delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.011 0.0152
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1262 0.2699
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0017 0.011 0.011
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0311 0.4557 0.4557
Onchocerca volvulus Huntingtin homolog 0.0374 0.552 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0417 0.0826
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.008 0.008
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0009 0.0009
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.011 0.0147
Echinococcus granulosus geminin 0.0531 0.7892 0.7892
Schistosoma mansoni coup transcription factor 0.002 0.0149 0.0149
Plasmodium vivax endoplasmin, putative 0.0044 0.0525 0.1546
Onchocerca volvulus 0.0231 0.3345 0.606
Echinococcus multilocularis cpg binding protein 0.0032 0.0339 0.0339
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0149 0.0149
Toxoplasma gondii exonuclease III APE 0.0037 0.0417 0.0826
Mycobacterium tuberculosis Probable reductase 0.0084 0.1121 0.2385
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0103 0.0131
Treponema pallidum heat shock protein 90 0.0042 0.0484 0.1413
Loa Loa (eye worm) hypothetical protein 0.0374 0.552 0.7683
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0301 0.0301
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0433 0.1293
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0342 0.066
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0342 0.0685
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0044 0.0062
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0149 0.0149
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0342 0.062
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.008 0.008
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.011 0.0152
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0397 0.7557
Leishmania major polypeptide deformylase-like protein, putative 0.0083 0.1112 0.2366
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0017 0.011 0.0154
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0149 0.0149
Schistosoma mansoni apoptosis regulator bax 0.0081 0.1085 0.1085
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0149 0.0149
Toxoplasma gondii ABC1 family protein 0.0038 0.0433 0.0861
Brugia malayi Muscleblind-like protein 0.0148 0.2101 0.2924
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0015 0.008 0.0111
Trypanosoma brucei heat shock protein 90, putative 0.0044 0.0525 0.1107
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0433 0.1058
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0342 0.062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0433 0.0602
Leishmania major mitochondrial DNA polymerase beta 0.03 0.439 0.963
Trichomonas vaginalis endoplasmin, putative 0.0032 0.0341 0.1018
Leishmania major trypanothione reductase 0.0037 0.0408 0.0806
Mycobacterium ulcerans aldehyde dehydrogenase 0.0311 0.4557 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0101 0.1375 0.1375
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.008 0.0111
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.011 0.0152
Schistosoma mansoni thyroid hormone receptor 0.002 0.0149 0.0149
Trypanosoma cruzi aldehyde dehydrogenase, putative 0.0017 0.011 0.0152
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0149 0.0208
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0433 0.1293
Mycobacterium ulcerans aldehyde dehydrogenase 0.0311 0.4557 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0015 0.008 0.008
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0428 0.128
Brugia malayi Endoplasmin precursor 0.0044 0.0525 0.0731
Echinococcus multilocularis muscleblind protein 0.0148 0.2101 0.2101
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0149 0.0149
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0433 0.0861
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0342 0.066
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.038 0.0529
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0017 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0484 0.1447
Brugia malayi Aldehyde dehydrogenase protein 4 0.0017 0.011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0094 0.127 0.1768
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.008 0.008
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0015 0.008 0.008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0415 0.0415
Echinococcus granulosus nAChR subunit 0.0015 0.008 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0433 0.0433
Mycobacterium ulcerans methylmalonate semialdehyde dehydrogenase, MmsA 0.0017 0.011 0.0147
Schistosoma mansoni hypothetical protein 0.0035 0.0381 0.0381
Entamoeba histolytica 90 kDa heat shock protein, putative 0.003 0.0299 0.5695
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0428 0.0883
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0096 0.0096
Entamoeba histolytica aldehyde dehydrogenase 1, putative 0.0017 0.011 0.2102
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.079 0.1099
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0015 0.008 0.008
Leishmania major delta-1-pyrroline-5-carboxylate dehydrogenase, putative 0.0017 0.011 0.0147
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0015 0.008 0.0111
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0417 0.0858
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.008 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.0311 0.4557 0.4557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0228 0.3308 0.3308
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.1999 0.4499
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0301 0.0301
Brugia malayi hypothetical protein 0.0484 0.7185 1
Onchocerca volvulus 0.0101 0.1375 0.2492
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0015 0.008 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0015 0.008 0.0111
Plasmodium falciparum heat shock protein 90, putative 0.0169 0.2405 0.759
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0397 0.0812
Echinococcus multilocularis pyruvate kinase 0.0032 0.0342 0.0342
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.008 0.008
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0017 0.011 0.011
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0015 0.008 0.0111
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0625 0.087
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 0.0017 0.011 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0417 0.0858
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0847 0.0847
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Schistosoma mansoni hypothetical protein 0.0016 0.0096 0.0096
Onchocerca volvulus 0.0015 0.008 0.0144
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0015 0.008 0.0111
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0038 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0038 0.0433 0.0602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0417 0.0858
Echinococcus multilocularis pyruvate kinase 0.0017 0.0103 0.0103
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase 0.0017 0.011 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0149 0.0208
Schistosoma mansoni ap endonuclease 0.0037 0.0417 0.0417
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0433 0.0861
Plasmodium vivax peptide deformylase, putative 0.0218 0.3155 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0433 0.0894
Echinococcus multilocularis glycine receptor subunit beta 0.0015 0.008 0.008
Treponema pallidum gamma-glutamyl phosphate reductase 0.0017 0.011 0.0213
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0342 0.1023
Toxoplasma gondii heat shock protein 90, putative 0.0044 0.0525 0.1066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0417 0.1198
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0149 0.0149
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0149 0.0208
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0096 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.067 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0149 0.0208
Trypanosoma cruzi heat shock protein 85, putative 0.0044 0.0525 0.1107
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0149 0.0208
Brugia malayi Thioredoxin reductase 0.0037 0.0408 0.0568
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0017 0.011 0.0154
Mycobacterium tuberculosis Probable aldehyde dehydrogenase AldC 0.0017 0.011 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0149 0.0208
Echinococcus granulosus FTZ F1 alpha 0.002 0.0149 0.0149
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0397 0.0397
Trypanosoma cruzi heat shock protein 90, putative 0.0044 0.0525 0.1107
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.049 0.1025
Trypanosoma brucei Heat shock protein 83, putative 0.0044 0.0525 0.1107
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.008 0.0111
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0015 0.008 0.008
Trypanosoma cruzi aldehyde dehydrogenase family, putative 0.0017 0.011 0.0152
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.1085 0.1511
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0433 0.0894
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.3308 0.3308
Echinococcus multilocularis heat shock protein 90 0.0044 0.0525 0.0525
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0149 0.0149
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0417 0.1198
Loa Loa (eye worm) hypothetical protein 0.0032 0.0342 0.0476
Schistosoma mansoni cpg binding protein 0.0032 0.0339 0.0339
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0301 0.0301
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.0017 0.011 0.011
Mycobacterium tuberculosis Probable aldehyde dehydrogenase (NAD+) dependent 0.0017 0.011 0.0147
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0149 0.0149
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1645 0.229
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0015 0.008 0.008
Echinococcus multilocularis GPCR, family 2 0.0016 0.0096 0.0096
Echinococcus granulosus pyruvate kinase 0.0017 0.0103 0.0103
Mycobacterium ulcerans gamma-glutamyl phosphate reductase 0.0017 0.011 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.3308 0.3308
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0342 0.0761
Echinococcus granulosus glycine receptor subunit alpha 1 0.0015 0.008 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0149 0.0208
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0149 0.0149
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Mycobacterium tuberculosis Conserved protein 0.0038 0.0433 0.0861
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0342 0.0685
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0408 0.0837
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0149 0.0149
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0017 0.011 0.0154
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.011 0.2102
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0149 0.0149
Brugia malayi beta-lactamase family protein 0.0038 0.0433 0.0602
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0149 0.0271
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0015 0.008 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0228 0.3308 0.3308
Echinococcus granulosus heat shock protein 90 0.0044 0.0525 0.0525
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1262 0.2699
Trypanosoma cruzi pyrroline-5-carboxylate synthetase-like protein, putative 0.0017 0.011 0.0152
Loa Loa (eye worm) hypothetical protein 0.0148 0.2101 0.2924
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0433 0.0861
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0042 0.0484 0.0974
Trypanosoma cruzi Peptide deformylase 2, putative 0.0083 0.1112 0.2457
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.049 0.1025
Brugia malayi steroid hormone receptor 0.002 0.0149 0.0208
Chlamydia trachomatis peptide deformylase 0.0218 0.3155 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase NAD dependent AldA (aldehyde dehydrogenase [NAD+]) 0.0017 0.011 0.0147
Loa Loa (eye worm) hypothetical protein 0.0038 0.0433 0.0602
Onchocerca volvulus 0.0101 0.1375 0.2492
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0218 0.3155 0.6894
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0228 0.3308 0.3308
Mycobacterium ulcerans hypothetical protein 0.0038 0.0433 0.0861
Brugia malayi nuclear receptor RXR 0.001 0.0009 0.0012
Entamoeba histolytica hypothetical protein 0.0035 0.0381 0.7245
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0311 0.4557 1
Chlamydia trachomatis pyruvate kinase 0.0032 0.0342 0.0957
Mycobacterium ulcerans succinate-semialdehyde dehydrogenase [NADP+] dependent, PutA_2 0.0017 0.011 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0629 0.1346
Mycobacterium ulcerans piperideine-6-carboxilic acid dehydrogenase Pcd 0.0017 0.011 0.0147
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0417 0.7748
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.034 0.0655
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0218 0.3155 1
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0243 0.0727
Toxoplasma gondii Hsp90 domain-containing protein 0.0169 0.2405 0.5233
Schistosoma mansoni inositol monophosphatase 0.0036 0.0397 0.0397
Schistosoma mansoni heat shock protein 0.0044 0.0525 0.0525
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0015 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0035 0.038 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0149 0.0208
Loa Loa (eye worm) LGC-31 protein 0.0015 0.008 0.0111
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0397 0.0782
Onchocerca volvulus Putative nachr subunit 0.0015 0.008 0.0144
Echinococcus granulosus GPCR family 2 0.0016 0.0096 0.0096
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.439 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0417 0.1247
Schistosoma mansoni pyruvate kinase 0.0032 0.0342 0.0342
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0015 0.008 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0625 0.087
Echinococcus granulosus tar DNA binding protein 0.0062 0.079 0.079
Plasmodium falciparum endoplasmin, putative 0.0032 0.0341 0.0952
Brugia malayi Pre-SET motif family protein 0.003 0.0301 0.0418
Mycobacterium ulcerans hypothetical protein 0.0158 0.2242 0.487
Loa Loa (eye worm) TAR-binding protein 0.0062 0.079 0.1099
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0194 0.3686
Schistosoma mansoni heat shock protein 0.0044 0.0525 0.0525
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0433 0.0894
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0015 0.008 0.008
Brugia malayi Hsp90 protein 0.003 0.0299 0.0416
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0433 0.1293
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0009 0.0012
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Plasmodium falciparum pyruvate kinase 0.0032 0.0342 0.0957
Leishmania major aldehyde dehydrogenase, putative 0.0017 0.011 0.0147
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0015 0.008 0.0111
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0742 0.1546
Loa Loa (eye worm) inositol-1 0.0036 0.0397 0.0553
Loa Loa (eye worm) hypothetical protein 0.001 0.0009 0.0012
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0341 0.1018
Mycobacterium ulcerans NAD-dependent aldehyde dehydrogenase AldA 0.0017 0.011 0.0147
Trypanosoma brucei heat shock protein 84, putative 0.003 0.0299 0.0587
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0149 0.0149
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Schistosoma mansoni nAChR subunit 0.0015 0.008 0.008
Giardia lamblia Grp94/Hsp90 0.0042 0.0484 0.914
Entamoeba histolytica aldehyde-alcohol dehydrogenase 2, putative 0.0017 0.011 0.2102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0433 0.0602
Loa Loa (eye worm) hypothetical protein 0.0101 0.1375 0.1914
Plasmodium vivax heat shock protein 90, putative 0.003 0.0299 0.0819
Mycobacterium tuberculosis Conserved protein 0.0038 0.0433 0.0861
Leishmania major heat shock protein 83-1 0.0044 0.0525 0.1066
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Wolbachia endosymbiont of Brugia malayi bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 0.0017 0.011 0.0213
Loa Loa (eye worm) hypothetical protein 0.0015 0.008 0.0111
Brugia malayi heat shock protein 90 0.0044 0.0525 0.0731
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0009 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0301 0.0568
Entamoeba histolytica hypothetical protein 0.0035 0.0381 0.7245
Giardia lamblia Heat shock protein HSP 90-alpha 0.0044 0.0525 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the P388 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.643 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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