Detailed information for compound 578303

Basic information

Technical information
  • TDR Targets ID: 578303
  • Name: 5-[(4,5-dimethoxy-2-methyl-phenyl)methyl]pyri midine-2,4-diamine
  • MW: 274.318 | Formula: C14H18N4O2
  • H donors: 2 H acceptors: 2 LogP: 1.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(Cc2cnc(nc2N)N)c(cc1OC)C
  • InChi: 1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18)
  • InChiKey: KEEYRKYKLYARHO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(4,5-dimethoxy-2-methylphenyl)methyl]pyrimidine-2,4-diamine
  • [2-amino-5-(4,5-dimethoxy-2-methyl-benzyl)pyrimidin-4-yl]amine
  • ormetoprim
  • 6981-18-6
  • NCIOpen2_006334
  • 2,4-Pyrimidinediamine, 5-[(4,5-dimethoxy-2-methylphenyl)methyl]-
  • Ormetoprim (USAN)
  • Pyrimidine, 2,4-diamino-5-(6-methylveratryl)-
  • D05273
  • NSC95072
  • AIDS-007291
  • AIDS007291
  • CV564
  • SD-051044
  • 2,4-Diamino-5-(4,5-dimethoxy-2-methylbenzyl)pyrimidin
  • 2,4-Diamino-5-(6-methylveratryl)pyrimidine
  • 2,4-Pyrimidinediamine, 5-((4,5-dimethoxy-2-methylphenyl)methyl)-
  • EINECS 230-246-6
  • NSC 95072
  • Ormetoprim [USAN:INN]
  • Ormetoprima [INN-Spanish]
  • Ormetoprime [INN-French]
  • Ormetoprimum [INN-Latin]
  • Ormetorprim
  • Pyrimidine, 2,4-diamino-5-(6-methylveratryl)- (8CI)
  • Ro 5-9754
  • component of Rofenaid
  • MLS000759503
  • SMR000466374

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus P2X purinoceptor 3 Starlite/ChEMBL References
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 2 Starlite/ChEMBL References
Homo sapiens galactosylceramidase No references
Homo sapiens purinergic receptor P2X, ligand-gated ion channel, 3 References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus p2X purinoceptor 4 P2X purinoceptor 3   397 aa 387 aa 37.0 %
Echinococcus multilocularis p2X purinoceptor 4 P2X purinoceptor 3   397 aa 451 aa 26.2 %
Schistosoma japonicum ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative P2X purinoceptor 3   397 aa 403 aa 37.0 %
Echinococcus multilocularis p2X purinoceptor 4 P2X purinoceptor 3   397 aa 385 aa 37.1 %
Echinococcus granulosus p2X purinoceptor 4 P2X purinoceptor 3   397 aa 385 aa 37.4 %
Echinococcus granulosus p2X purinoceptor 4 purinergic receptor P2X, ligand-gated ion channel, 3 397 aa 383 aa 37.1 %
Schistosoma japonicum ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative P2X purinoceptor 3   397 aa 399 aa 38.3 %
Schistosoma japonicum ko:K05218 purinergic receptor P2X, ligand-gated ion channel 4, putative P2X purinoceptor 3   397 aa 375 aa 40.3 %
Schistosoma mansoni P2X receptor subunit P2X purinoceptor 3   397 aa 371 aa 41.0 %
Echinococcus granulosus p2X purinoceptor 4 P2X purinoceptor 3   397 aa 447 aa 26.8 %
Schistosoma japonicum ko:K00599 protein arginine N-methyltransferase 5 [EC:2.1.1.-], putative P2X purinoceptor 3   397 aa 398 aa 25.6 %
Echinococcus multilocularis p2X purinoceptor 4 P2X purinoceptor 3   397 aa 387 aa 36.7 %
Echinococcus granulosus p2X purinoceptor 4 purinergic receptor P2X, ligand-gated ion channel, 2 370 aa 409 aa 29.1 %
Dictyostelium discoideum hypothetical protein P2X purinoceptor 3   397 aa 383 aa 19.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0063 0.0084 0.0217
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0045
Trichomonas vaginalis glutathione reductase, putative 0.0063 0.0084 0.205
Brugia malayi Thioredoxin reductase 0.0182 0.0291 0.3394
Schistosoma mansoni microtubule-associated protein tau 0.5755 1 1
Brugia malayi glutamate synthase 0.0017 0.0003 0.0034
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0245 0.0401 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0028 0.0027
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0039 0.1303
Plasmodium falciparum glutathione reductase 0.0182 0.0291 0.7259
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0031 0.003
Echinococcus multilocularis lamin dm0 0.0028 0.0023 0.0022
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0003 0.0045
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0491 0.0828 0.2223
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0055 0.3073
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0028 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0088 0.0088
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0004 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0063 0.0084 0.2071
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0076 0.0075
Brugia malayi hypothetical protein 0.0026 0.0019 0.0226
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2152 0.3722 1
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0003 0.0045
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0045
Entamoeba histolytica hypothetical protein 0.0115 0.0174 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0055 0.1347
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.1254
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0011
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0462 0.0778 0.2081
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0023 0.0265
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0154 0.1794
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0034 0.0839
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0245 0.0401 0.1067
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0121 0.2999
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0462 0.0778 0.2089
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0108 0.0107
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0084 0.2853
Brugia malayi Pre-SET motif family protein 0.0217 0.0352 0.4102
Onchocerca volvulus 0.0209 0.0338 0.8362
Loa Loa (eye worm) hypothetical protein 0.0033 0.0031 0.0358
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0003 0.0069
Plasmodium vivax glutathione reductase, putative 0.0182 0.0291 0.7259
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0019 0.0462
Echinococcus granulosus tar DNA binding protein 0.0066 0.0088 0.0088
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0027 0.0636
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0003 0.005
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0004 0.0035
Mycobacterium ulcerans lipase LipD 0.0077 0.0108 0.0281
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0108 0.0286
Onchocerca volvulus 0.0103 0.0154 0.3767
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0017 0.0003 0.005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0063 0.0084 0.0976
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0019 0.0636
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0076 0.0075
Entamoeba histolytica hypothetical protein 0.0115 0.0174 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0028 0.0027
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0003 0.0034
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0076 0.0075
Schistosoma mansoni transcription factor LCR-F1 0.0115 0.0174 0.0173
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0017 0.0003 0.005
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0011
Echinococcus granulosus p2X purinoceptor 4 0.0246 0.0402 0.0401
Echinococcus multilocularis ferritin 0.0018 0.0004 0.0003
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0063 0.0084 0.2031
Mycobacterium ulcerans TetR family transcriptional regulator 0.2156 0.373 1
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0031 0.0358
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0003 0.0069
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0028 0.0027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0183 0.0293 0.0292
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0003 0.005
Loa Loa (eye worm) hypothetical protein 0.0031 0.0028 0.0326
Schistosoma mansoni P2X receptor subunit 0.0246 0.0402 0.0401
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0031 0.0358
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0069
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0265
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0055 0.0054
Brugia malayi jmjC domain containing protein 0.0059 0.0076 0.0883
Plasmodium falciparum thioredoxin reductase 0.0182 0.0291 0.7259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0415
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 0.1067
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0003 0.0002
Echinococcus granulosus p2X purinoceptor 4 0.0246 0.0402 0.0401
Loa Loa (eye worm) hypothetical protein 0.0507 0.0857 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0017 0.0003 0.0045
Mycobacterium ulcerans beta-lactamase 0.0077 0.0108 0.0281
Brugia malayi hypothetical protein 0.0115 0.0174 0.2024
Entamoeba histolytica hypothetical protein 0.0115 0.0174 1
Brugia malayi beta-lactamase family protein 0.0077 0.0108 0.1254
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0108 0.0286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0415
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0017 0.0003 0.0005
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0001 0.0006
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0001 0.0013
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0003 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0182 0.0291 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0007
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0003 0.0034
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0003 0.0069
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0069
Schistosoma mansoni hypothetical protein 0.0115 0.0174 0.0173
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0063 0.0084 0.0217
Trypanosoma brucei NADH dehydrogenase 0.0017 0.0003 0.0069
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0245 0.0401 1
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0003 0.0002
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0108 0.1254
Giardia lamblia NADH oxidase lateral transfer candidate 0.0063 0.0084 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0063 0.0084 0.2071
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0003 0.0069
Mycobacterium tuberculosis Conserved protein 0.0077 0.0108 0.0286
Echinococcus granulosus glutamate synthase 0.0017 0.0003 0.0002
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0161 0.0254 0.0678
Loa Loa (eye worm) hypothetical protein 0.0071 0.0097 0.1129
Brugia malayi jmjC domain containing protein 0.0059 0.0076 0.0883
Echinococcus multilocularis microtubule associated protein 2 0.5755 1 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0003 0.0069
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 1
Trichomonas vaginalis mercuric reductase, putative 0.0063 0.0084 0.205
Loa Loa (eye worm) hypothetical protein 0.0028 0.0022 0.0255
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0003 0.005
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0108 0.2641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0039 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0055 0.1347
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0017 0.0003 0.005
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0055 0.1876
Loa Loa (eye worm) beta-lactamase 0.0077 0.0108 0.1254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Mycobacterium tuberculosis Probable reductase 0.0415 0.0698 0.1871
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0108 0.0286
Schistosoma mansoni hypothetical protein 0.0103 0.0154 0.0153
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0108 0.2666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0029 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0039 0.0932
Plasmodium falciparum glutathione reductase 0.0063 0.0084 0.2071
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0084 0.0121 0.0316
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0028 0.0027
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0055 0.1876
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0063 0.0084 0.2853
Leishmania major hypothetical protein, conserved 0.0026 0.0019 0.0636
Echinococcus multilocularis GPCR, family 2 0.0033 0.0031 0.003
Echinococcus granulosus ferritin 0.0018 0.0004 0.0003
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0076 0.0075
Mycobacterium tuberculosis Conserved protein 0.0077 0.0108 0.0286
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0005
Onchocerca volvulus 0.0028 0.0023 0.0494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0531
Mycobacterium tuberculosis Conserved protein 0.0077 0.0108 0.0286
Echinococcus multilocularis p2X purinoceptor 4 0.0246 0.0402 0.0401
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0031 0.003
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.003
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.0001 0.0006
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0076 0.0883
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0004 0.0004
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.0188 0.2198
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 0.1067
Echinococcus granulosus tumor protein p63 0.1429 0.2464 0.2463
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0055 0.3073
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0003 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0063 0.0084 0.0083
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0108 0.1254
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0084 0.2853
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.0001 0.0006
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0003 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0055 0.1876
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0088 0.1032
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0001 0.0013
Treponema pallidum NADH oxidase 0.0063 0.0084 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0039 0.0932
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Echinococcus multilocularis glutamate synthase 0.0017 0.0003 0.0002
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0415 0.0698 0.1871
Loa Loa (eye worm) glutathione reductase 0.0182 0.0291 0.3394
Brugia malayi TAR-binding protein 0.0066 0.0088 0.1032
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0115 0.0174 0.0173
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0023 0.0265
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0108 0.2641
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0055 0.0646
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0046 0.0055 0.0636
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0008 0.0231
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0055 0.1876
Loa Loa (eye worm) thioredoxin reductase 0.0182 0.0291 0.3394
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 1
Toxoplasma gondii thioredoxin reductase 0.0182 0.0291 0.7259
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0108 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0088 0.0088
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0017 0.0003 0.005
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0017 0.0003 0.0005
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0161 0.0254 0.0672
Echinococcus multilocularis tumor protein p63 0.1429 0.2464 0.2463
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0462 0.0778 0.2089
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.0188 0.2198
Entamoeba histolytica hypothetical protein 0.0115 0.0174 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0063 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0011
Brugia malayi jmjC domain containing protein 0.0016 0.0001 0.0011
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0063 0.0084 0.2853
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0154 0.1794
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0012 0.0393
Trichomonas vaginalis glutamate synthase, putative 0.0017 0.0003 0.0045
Onchocerca volvulus 0.0077 0.0108 0.2608
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0003 0.0069
Toxoplasma gondii selenide, water dikinase 0.0017 0.0003 0.005
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0003 0.0069
Toxoplasma gondii hypothetical protein 0.0084 0.0121 0.2999
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0415 0.0698 0.1871
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0001 0.0007
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0028 0.0027
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0063 0.0084 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0019 0.0226
Echinococcus granulosus lamin 0.0028 0.0023 0.0022
Toxoplasma gondii NADPH-glutathione reductase 0.0063 0.0084 0.2071
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0055 0.0054
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0245 0.0401 0.04
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0063 0.0084 0.2853
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0063 0.0084 0.0217
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0108 0.0107
Echinococcus multilocularis musashi 0.0028 0.0023 0.0022
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0108 0.0107
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0058 0.068
Echinococcus multilocularis p2X purinoceptor 4 0.0246 0.0402 0.0401
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0154 0.1794
Echinococcus multilocularis peptidase Clp (S14 family) 0.0161 0.0254 0.0253
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0131 0.0202 0.0201
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0415 0.0698 0.1864
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.1254
Schistosoma mansoni P2X receptor subunit 0.0246 0.0402 0.0401
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0004 0.0009
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0245 0.0401 0.04
Echinococcus multilocularis survival motor neuron protein 1 0.0507 0.0857 0.0857
Toxoplasma gondii ABC1 family protein 0.0077 0.0108 0.2666
Echinococcus granulosus GPCR family 2 0.0033 0.0031 0.003
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0069
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.003
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0161 0.0254 0.0678
Trichomonas vaginalis ferritin, putative 0.0018 0.0004 0.008
Echinococcus granulosus peptidase Clp S14 family 0.0161 0.0254 0.0253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0531
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0245 0.0401 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.0001 0.0013
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0108 0.0281
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0039 0.1303
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0019 0.0462
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0063 0.0084 0.2071
Schistosoma mansoni glutamate synthase 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0043 0.105
Brugia malayi MH2 domain containing protein 0.0123 0.0188 0.2198
Onchocerca volvulus 0.0077 0.0108 0.2608
Echinococcus granulosus lamin dm0 0.0028 0.0023 0.0022
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0055 0.1876
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0026 0.0025
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0023 0.0265
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0131 0.0202 0.0201
Brugia malayi Probable ClpP-like protease 0.0245 0.0401 0.4672
Schistosoma mansoni hypothetical protein 0.0131 0.0202 0.0201
Trypanosoma cruzi trypanothione reductase, putative 0.0063 0.0084 0.2853
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0003 0.0002
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0017 0.0003 0.0005
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0003 0.0069
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0019 0.0636
Mycobacterium leprae Probable lipase LipE 0.0077 0.0108 0.0281
Schistosoma mansoni intermediate filament proteins 0.0028 0.0023 0.0022
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0055 0.1347
Giardia lamblia GTOR 0.0047 0.0055 0.6492
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0022 0.0519
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0063 0.0084 0.2853
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0063 0.0084 0.2853
Schistosoma mansoni hypothetical protein 0.0071 0.0097 0.0096
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0069
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0004 0.0009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0039 0.0932
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0088 0.0088
Schistosoma mansoni thyroid hormone receptor 0.0141 0.022 0.0219
Schistosoma mansoni glutamate synthase 0.0017 0.0003 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Brugia malayi isocitrate dehydrogenase 0.0016 0.0001 0.0013
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0121 0.2964
Schistosoma mansoni hypothetical protein 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0088 0.0088
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0055 0.1876
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0413
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0084 0.2031
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0108 0.3673
Brugia malayi intermediate filament protein 0.0028 0.0023 0.0265
Trichomonas vaginalis apoptosis inducing factor, putative 0.0017 0.0003 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0019 0.0636
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0108 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Brugia malayi beta-lactamase family protein 0.0077 0.0108 0.1254
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0031 0.003
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0003 0.0069
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0004 0.0004
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0063 0.0084 0.0222
Schistosoma mansoni apoferritin-2 0.0018 0.0004 0.0003
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0003 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0141 0.022 0.0219
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2156 0.373 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Loa Loa (eye worm) RNA binding protein 0.0066 0.0088 0.1032
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0088 0.1032
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0017 0.0003 0.0069
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0055 0.0646
Echinococcus multilocularis p2X purinoceptor 4 0.0246 0.0402 0.0401
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0045
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.0001 0.0006
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0003 0.0069
Schistosoma mansoni lamin 0.0028 0.0023 0.0022
Echinococcus granulosus survival motor neuron protein 1 0.0507 0.0857 0.0857
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0108 0.2641
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0055 0.0054
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0017 0.0003 0.0045
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0415
Schistosoma mansoni survival motor neuron protein 0.0103 0.0154 0.0153
Plasmodium vivax thioredoxin reductase, putative 0.0182 0.0291 0.7259
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0017 0.0003 0.0045
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0108 0.0286
Loa Loa (eye worm) hypothetical protein 0.0209 0.0338 0.3945
Loa Loa (eye worm) hypothetical protein 0.0017 0.0003 0.0034
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0017 0.0003 0.0005
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0017 0.0003 0.0005
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0019 0.0462
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0017 0.0003 0.0005
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0001 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0088 0.0088
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0003 0.0002
Echinococcus granulosus p2X purinoceptor 4 0.0246 0.0402 0.0401
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0003 0.0002
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.1254
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0028 0.0027
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0003 0.0034
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0088 0.0088
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0088 0.1032
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.1254
Leishmania major hypothetical protein, conserved 0.0077 0.0108 0.3673
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0003 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0019 0.0462
Loa Loa (eye worm) hypothetical protein 0.0103 0.0154 0.1794
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2156 0.373 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0076 0.0075
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0003 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0001 0.0011
Mycobacterium ulcerans transcriptional regulator 0.2156 0.373 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0022 0.0519
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0076 0.0075
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0004 0.0035
Brugia malayi hypothetical protein 0.0017 0.0003 0.0038
Brugia malayi hypothetical protein 0.0507 0.0857 1
Schistosoma mansoni ferritin light chain 0.0018 0.0004 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0108 0.0286
Echinococcus granulosus expressed protein 0.0018 0.0004 0.0003
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0001 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0108 0.0286
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0017 0.0003 0.005
Plasmodium vivax SET domain protein, putative 0.0031 0.0028 0.0676
Trichomonas vaginalis esterase, putative 0.0077 0.0108 0.2641
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0415
Mycobacterium ulcerans hypothetical protein 0.0077 0.0108 0.0281
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0003 0.0034
Schistosoma mansoni cellular tumor antigen P53 0.0209 0.0338 0.0337
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0007
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0045
Plasmodium vivax ferrodoxin reductase, putative 0.0017 0.0003 0.005
Schistosoma mansoni P2X receptor subunit 0.0246 0.0402 0.0401
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0108 0.0286
Brugia malayi RNA binding protein 0.0066 0.0088 0.1032
Mycobacterium tuberculosis Probable dehydrogenase 0.0415 0.0698 0.1871
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.0001 0.0006
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0063 0.0084 0.2071
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0108 0.0281
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0121 0.2999
Onchocerca volvulus 0.0031 0.0028 0.0624
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0415 0.0698 0.1871
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0063 0.0084 0.2853
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0001 0.0011
Trypanosoma brucei trypanothione reductase 0.0182 0.0291 1
Echinococcus multilocularis lamin 0.0028 0.0023 0.0022
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0415 0.0698 0.1871
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0154 0.1796
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0003 0.0002
Echinococcus granulosus thioredoxin glutathione reductase 0.0183 0.0293 0.0292
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0017 0.0003 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0039 0.0932
Schistosoma mansoni lamin 0.0028 0.0023 0.0022
Onchocerca volvulus 0.0028 0.0023 0.0494
Schistosoma mansoni peptidase Clp (S14 family) 0.0245 0.0401 0.04
Echinococcus multilocularis expressed protein 0.0018 0.0004 0.0003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0045
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.0531
Leishmania major hypothetical protein, conserved 0.0017 0.0003 0.0069
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0003 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Schistosoma mansoni ferritin 0.0018 0.0004 0.0003
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0108 0.2641
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0063 0.0084 0.2853
Mycobacterium tuberculosis Probable oxidoreductase 0.0462 0.0778 0.2089
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0108 0.2641
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0063 0.0084 0.2071
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0039 0.1303
Schistosoma mansoni thyroid hormone receptor 0.0141 0.022 0.0219
Loa Loa (eye worm) hypothetical protein 0.0016 0.0001 0.0011
Leishmania major NADH dehydrogenase, putative 0.0017 0.0003 0.0069
Onchocerca volvulus 0.0077 0.0108 0.2608
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0108 0.3673
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0001 0.0007
Brugia malayi glutathione reductase 0.0182 0.0291 0.3394
Brugia malayi Pre-SET motif family protein 0.0031 0.0028 0.0326
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0028 0.0676
Trichomonas vaginalis set domain proteins, putative 0.0247 0.0404 1
Schistosoma mansoni hypothetical protein 0.0033 0.0031 0.003
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0046 0.0055 0.0636
Onchocerca volvulus 0.0247 0.0404 1
Leishmania major trypanothione reductase 0.0182 0.0291 1
Schistosoma mansoni glutamate synthase 0.0017 0.0003 0.0002
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0003 0.0069
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0001 0.0007
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0003 0.0069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.0352 0.4102
Brugia malayi beta-lactamase 0.0077 0.0108 0.1254
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0245 0.0401 0.4672
Schistosoma mansoni P2X receptor subunit 0.0246 0.0402 0.0401
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.1254
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0245 0.0401 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Echinococcus granulosus intermediate filament protein 0.0028 0.0023 0.0022
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0001 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0001 0.0011
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0063 0.0084 0.2031
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0097 0.1129
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0003 0.0034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0115 0.0174 0.0173
Loa Loa (eye worm) hypothetical protein 0.0077 0.0108 0.1254
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0001 0.0005
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0017 0.0003 0.0045
Brugia malayi Cytochrome P450 family protein 0.0049 0.0058 0.068
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0108 0.3673
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0034 0.0827
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0031 0.0358
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0076 0.0075
Plasmodium falciparum thioredoxin reductase 0.0063 0.0084 0.2071
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0182 0.0291 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0018 0.0413
Plasmodium falciparum ferrodoxin reductase-like protein 0.0017 0.0003 0.005

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 5 Antagonist activity at human recombinant P2X2/3 receptor expressed in human 1321N1 cells by FLIPR assay ChEMBL. 19231180
IC50 (functional) > 5 Antagonist activity at rat recombinant P2X3 receptor expressed in CHO cells by FLIPR assay ChEMBL. 19231180
Potency (functional) 0.7079 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.6855 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 3.7933 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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