Detailed information for compound 580745

Basic information

Technical information
  • TDR Targets ID: 580745
  • Name: (6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14- tetraenoic acid
  • MW: 336.466 | Formula: C20H32O4
  • H donors: 2 H acceptors: 3 LogP: 5.29 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)OO
  • InChi: 1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+
  • InChiKey: JNUUNUQHXIOFDA-XTDASVJISA-N  


Substructure search Similarity search

Network

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Synonyms

  • arachidonic acid 5-hydroperoxide
  • 74581-83-2
  • cis,trans-5-Hydroperoxy-6,8,11,14-eicosatetraenoic acid
  • 5-Hpete
  • 6,8,11,14-Eicosatetraenoic acid 5-hydroperoxide
  • 6,8,11,14-Eicosatetraenoic acid, 5-hydroperoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0039 0.0092 0.0127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0464 0.0461
Echinococcus multilocularis dnaJ subfamily B 0.1245 0.8719 0.8719
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0055 0.0112
Brugia malayi beta-lactamase family protein 0.0079 0.0378 0.0615
Toxoplasma gondii 1,3-beta-glucan synthase component protein 0.0496 0.3362 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0505 0.3424 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Echinococcus granulosus peregrin 0.0031 0.0035 0.0033
Brugia malayi mbt repeat family protein 0.0145 0.0852 0.1424
Brugia malayi Cell death protein 3 precursor 0.0437 0.2938 0.4988
Echinococcus granulosus chromobox protein 1 0.014 0.0811 0.0809
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0297 0.0477
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0178 0.1083 0.1819
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Brugia malayi jmjC domain containing protein 0.0094 0.0485 0.0797
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0471 0.3184 0.3183
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0061 0.0055
Onchocerca volvulus Glucosylceramidase homolog 0.035 0.2319 0.344
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0218 0.1373 0.1371
Echinococcus granulosus cpg binding protein 0.0124 0.0701 0.0699
Trichomonas vaginalis esterase, putative 0.0079 0.0378 0.0563
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1431 0.2133
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0018 0.0015
Echinococcus granulosus SAM and MBT domain containing protein 0.0145 0.0852 0.085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0163 0.0244
Schistosoma mansoni caspase-7 (C14 family) 0.0437 0.2938 0.2937
Trypanosoma brucei Metacaspase-4 0.0226 0.1431 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0598 0.4092 0.409
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1431 0.2133
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.0733 0.2258
Brugia malayi beta-lactamase family protein 0.0079 0.0378 0.0615
Schistosoma mansoni hypothetical protein 0.0178 0.1083 0.1081
Schistosoma mansoni survival motor neuron protein 0.0051 0.0174 0.0172
Brugia malayi beta-lactamase 0.0079 0.0378 0.0615
Echinococcus granulosus survival motor neuron protein 1 0.0248 0.1587 0.1585
Loa Loa (eye worm) hypothetical protein 0.0384 0.2557 0.4337
Schistosoma mansoni chromobox protein 0.014 0.0811 0.0809
Echinococcus granulosus histone lysine methyltransferase setb 0.0141 0.0822 0.0819
Echinococcus multilocularis SAM and MBT domain containing protein 0.0145 0.0852 0.085
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0055 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0369 0.2454 0.3658
Loa Loa (eye worm) beta-lactamase 0.0079 0.0378 0.0615
Schistosoma mansoni hypothetical protein 0.0051 0.0174 0.0172
Brugia malayi Bromodomain containing protein 0.0083 0.0407 0.0664
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Brugia malayi hypothetical protein 0.0248 0.1587 0.268
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0042 0.004
Brugia malayi regulator of G-protein signaling egl-10 0.0042 0.0115 0.0167
Loa Loa (eye worm) CXXC zinc finger family protein 0.0116 0.064 0.1063
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0471 0.3184 0.3183
Schistosoma mansoni hypothetical protein 0.0178 0.1083 0.1081
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0042 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0378 0.2416
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0573 0.3908 0.3907
Loa Loa (eye worm) hypothetical protein 0.0145 0.0852 0.1424
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0309 0.2023 0.5857
Schistosoma mansoni hypothetical protein 0.0883 0.6131 0.613
Loa Loa (eye worm) hypothetical protein 0.0211 0.132 0.2224
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0378 0.1137
Giardia lamblia Fructose-bisphosphate aldolase 0.0288 0.187 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0297 0.0477
Plasmodium falciparum importin beta, putative 0.0034 0.0055 0.0118
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0145 0.0852 0.085
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0093 0.0091
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0226 0.1431 0.2414
Trichomonas vaginalis glucosylceramidase, putative 0.0534 0.3633 0.5416
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0362 0.2402 0.4071
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0122 0.0178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.025 0.16 0.1598
Loa Loa (eye worm) hypothetical protein 0.0079 0.0378 0.0615
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0033 0.005 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0033 0.005 0.0047
Schistosoma mansoni microtubule-associated protein tau 0.1412 0.9912 0.9912
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.027 0.0267
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0378 0.0375
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0079 0.0378 0.0615
Onchocerca volvulus 0.0465 0.3136 0.4661
Loa Loa (eye worm) heterochromatin protein 1 0.014 0.0811 0.1355
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.009 0.0568
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0165 0.0996 0.0993
Echinococcus multilocularis caspase 0.0598 0.4092 0.409
Echinococcus granulosus polycomb protein SCMH1 0.0145 0.0852 0.085
Brugia malayi N-terminal motif family protein 0.039 0.2604 0.4417
Mycobacterium leprae Probable lipase LipE 0.0079 0.0378 0.1015
Trypanosoma brucei PAB1-binding protein , putative 0.0129 0.0733 0.4972
Onchocerca volvulus 0.0116 0.064 0.093
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0186 0.0288
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0042 0.0073
Brugia malayi hypothetical protein 0.0211 0.132 0.2224
Loa Loa (eye worm) hypothetical protein 0.005 0.0171 0.0261
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 1
Brugia malayi hypothetical protein 0.0129 0.0733 0.1221
Trichomonas vaginalis glucosylceramidase, putative 0.0369 0.2454 0.3658
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0042 0.0115 0.0167
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0378 0.0375
Toxoplasma gondii ABC1 family protein 0.0079 0.0378 0.1077
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0378 0.0992
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0218 0.1373 0.1371
Echinococcus granulosus dnaJ subfamily B 0.1245 0.8719 0.8719
Echinococcus multilocularis caspase 8 0.0226 0.1431 0.1429
Loa Loa (eye worm) histone methyltransferase 0.004 0.01 0.0141
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0378 0.0563
Brugia malayi F/Y-rich N-terminus family protein 0.0051 0.0178 0.0274
Brugia malayi chromobox protein homolog 3 0.0078 0.0372 0.0606
Echinococcus granulosus GPCR family 2 0.0178 0.1083 0.1081
Loa Loa (eye worm) hypothetical protein 0.0165 0.0996 0.167
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.0733 0.5088
Onchocerca volvulus 0.0964 0.6708 1
Schistosoma mansoni hypothetical protein 0.0178 0.1083 0.1081
Schistosoma mansoni chromobox protein 0.014 0.0811 0.0809
Loa Loa (eye worm) hypothetical protein 0.0129 0.0733 0.1221
Echinococcus granulosus expressed protein 0.0451 0.3036 0.3034
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0297 0.2025
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0573 0.3908 0.3907
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0226 0.1431 0.4226
Schistosoma mansoni cpg binding protein 0.0124 0.0701 0.0699
Loa Loa (eye worm) hypothetical protein 0.0437 0.2938 0.4988
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0163 0.0244
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0378 0.0992
Plasmodium falciparum metacaspase 1 0.0226 0.1431 0.4463
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0372 0.0555
Trichomonas vaginalis chromobox protein, putative 0.014 0.0811 0.1209
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0178 0.1083 0.1081
Schistosoma mansoni hypothetical protein 0.1245 0.8719 0.8719
Echinococcus multilocularis chromobox protein 1 0.014 0.0811 0.0809
Trypanosoma cruzi metacaspase 5, putative 0.0226 0.1431 1
Onchocerca volvulus Cell death protein 3 homolog 0.0437 0.2938 0.4366
Trypanosoma brucei metacaspase 5, putative 0.0226 0.1431 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0055 0.0092
Loa Loa (eye worm) hypothetical protein 0.0248 0.1587 0.268
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0042 0.004
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.039 0.2604 0.3866
Brugia malayi Pre-SET motif family protein 0.0847 0.5873 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0534 0.3633 0.6174
Brugia malayi hypothetical protein 0.0465 0.3136 0.5326
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.0024 0.0022
Leishmania major metacaspase, putative 0.0226 0.1431 1
Trypanosoma brucei metacaspase MCA2 0.0226 0.1431 1
Onchocerca volvulus 0.0079 0.0378 0.0538
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.009 0.0134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0178 0.1083 0.1081
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0141 0.0818 0.2351
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0209 0.0311
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.1548 0.2614
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0464 0.0461
Loa Loa (eye worm) hypothetical protein 0.0146 0.0853 0.1427
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0115 0.0113
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0464 0.0461
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0042 0.0232
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0822 0.0819
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0141 0.0818 0.2293
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0178 0.1083 0.1081
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0218 0.1373 0.1371
Loa Loa (eye worm) hypothetical protein 0.0072 0.0328 0.0531
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Onchocerca volvulus 0.0061 0.0251 0.0349
Echinococcus multilocularis caspase 3 0.0372 0.2473 0.2471
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Echinococcus granulosus snurportin 1 0.0362 0.2402 0.24
Loa Loa (eye worm) mbt repeat family protein 0.0145 0.0852 0.1424
Loa Loa (eye worm) hypothetical protein 0.0087 0.0433 0.0709
Echinococcus granulosus caspase 2 0.0437 0.2938 0.2937
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0146 0.0853 0.0851
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0309 0.2023 0.6281
Loa Loa (eye worm) hypothetical protein 0.0471 0.3184 0.5408
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0485 0.0482
Loa Loa (eye worm) MBCTL1 0.0165 0.0996 0.167
Loa Loa (eye worm) hypothetical protein 0.0465 0.3136 0.5326
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0471 0.3184 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0378 0.0615
Brugia malayi latrophilin 2 splice variant baaae 0.0384 0.2557 0.4337
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0124 0.0697 0.2032
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0295 0.0293
Echinococcus multilocularis GPCR, family 2 0.0178 0.1083 0.1081
Trichomonas vaginalis glucosylceramidase, putative 0.0534 0.3633 0.5416
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0378 0.0992
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0433 0.2276
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0042 0.004
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.027 0.043
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0464 0.0461
Schistosoma mansoni sex comb on midleg homolog 0.0145 0.0852 0.085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0822 0.0819
Loa Loa (eye worm) runx1 0.0058 0.0229 0.0362
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.009 0.0434
Echinococcus granulosus regulator of G protein signaling 7 0.0042 0.0115 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1431 0.2133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0378 0.0375
Trypanosoma cruzi metacaspase, putative 0.0226 0.1431 1
Brugia malayi Bromodomain containing protein 0.0031 0.0035 0.0029
Echinococcus multilocularis snurportin 1 0.0362 0.2402 0.24
Echinococcus multilocularis chromobox protein 1 0.014 0.0811 0.0809
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.187 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.027 0.0267
Plasmodium falciparum ataxin-2 like protein, putative 0.0129 0.0733 0.2258
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0141 0.0818 0.2423
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0122 0.012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0077 0.0114
Loa Loa (eye worm) hypothetical protein 0.0465 0.3136 0.5326
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0297 0.0295
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0009 0.0014
Echinococcus multilocularis polycomb protein SCMH1 0.0145 0.0852 0.085
Loa Loa (eye worm) hypothetical protein 0.0079 0.0378 0.0615
Trichomonas vaginalis glucosylceramidase, putative 0.0534 0.3633 0.5416
Trypanosoma brucei metacaspase 0.0226 0.1431 1
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.009 0.0087
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0031 0.0033 0.0031
Echinococcus granulosus caspase 0.0598 0.4092 0.409
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0162 0.0974 0.302
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Toxoplasma gondii histone lysine methyltransferase SET1 0.0226 0.1429 0.4221
Brugia malayi CXXC zinc finger family protein 0.0116 0.064 0.1063
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0042 0.0077
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0297 0.0295
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0018 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0163 0.0244
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0226 0.1431 0.4226
Onchocerca volvulus 0.0211 0.132 0.1946
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0415 0.0618
Trypanosoma cruzi PAB1-binding protein , putative 0.0129 0.0733 0.5088
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0378 0.0992
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0009 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0115 0.0167
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.009 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1431 0.2133
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0226 0.1431 0.4226
Brugia malayi Latrophilin receptor protein 2 0.0178 0.1083 0.1819
Schistosoma mansoni hypothetical protein 0.0178 0.1083 0.1081
Loa Loa (eye worm) CHromoDomain protein family member 0.0031 0.0037 0.0033
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.009 0.0568
Leishmania major hypothetical protein, conserved 0.0129 0.0733 0.5088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0043 0.0117 0.0115
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0347 0.0344
Echinococcus multilocularis geminin 0.1424 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0378 0.0992
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Schistosoma mansoni hypothetical protein 0.1424 1 1
Schistosoma mansoni hypothetical protein 0.0362 0.2402 0.24
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0141 0.0822 0.0819
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0163 0.0244
Trypanosoma cruzi metacaspase, putative 0.0226 0.1431 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0163 0.0244
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0122 0.012
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.009 0.0134
Brugia malayi mbt repeat family protein 0.0145 0.0852 0.1424
Loa Loa (eye worm) hypothetical protein 0.039 0.2604 0.4417
Schistosoma mansoni bromodomain containing protein 0.0071 0.0321 0.0319
Schistosoma mansoni lozenge 0.0058 0.0229 0.0227
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.009 0.0134
Loa Loa (eye worm) hypothetical protein 0.0061 0.0251 0.0399
Brugia malayi MH2 domain containing protein 0.0243 0.1548 0.2614
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0471 0.3184 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0124 0.0697 0.0695
Loa Loa (eye worm) hypothetical protein 0.0561 0.3827 0.6506
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0464 0.0461
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.004 0.01 0.0098
Echinococcus granulosus importin subunit beta 1 0.0034 0.0055 0.0053
Trichomonas vaginalis set domain proteins, putative 0.0964 0.6708 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0309 0.2023 0.2021
Onchocerca volvulus 0.0051 0.0174 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0055 0.0092
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0145 0.0852 0.1247
Loa Loa (eye worm) hypothetical protein 0.0226 0.1431 0.2414
Brugia malayi RNA, U transporter 1 0.0096 0.0502 0.0827
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.027 0.0581
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0115 0.0113
Mycobacterium ulcerans lipase LipD 0.0079 0.0378 0.093
Schistosoma mansoni z-protein (S1r protein) 0.0042 0.0115 0.0113
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0058 0.0225 0.0223
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0297 0.2025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0561 0.3827 0.6506
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0378 0.0375
Toxoplasma gondii Alpha-galactosidase 0.0031 0.0033 0.0047
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0378 0.0992
Loa Loa (eye worm) hypothetical protein 0.0178 0.1083 0.1819
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0049 0.0164 0.025
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0093 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0035 0.0063 0.0094
Trichomonas vaginalis chromobox protein, putative 0.014 0.0811 0.1209
Trypanosoma brucei metacaspase MCA3 0.0226 0.1431 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0042 0.0077
Echinococcus granulosus caspase 8 0.0226 0.1431 0.1429
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0847 0.5873 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0295 0.0293
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Echinococcus multilocularis apoptotic protease activating factor 1 0.0211 0.132 0.1318
Trypanosoma cruzi metacaspase, putative 0.0226 0.1431 1
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0378 0.2592
Mycobacterium tuberculosis Conserved protein 0.0079 0.0378 0.0992
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0178 0.1083 0.1081
Trypanosoma cruzi metacaspase 5, putative 0.0226 0.1431 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0018 0.0015
Echinococcus granulosus histone acetyltransferase MYST2 0.0165 0.0996 0.0993
Onchocerca volvulus 0.0149 0.0878 0.1285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0464 0.0461
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0075 0.0072
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0165 0.0996 0.0993
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0009 0.0014
Brugia malayi Inositol-1 0.0039 0.009 0.0123
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0174 0.0268
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0378 0.0992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0464 0.0461
Schistosoma mansoni cpg binding protein 0.0116 0.064 0.0638
Loa Loa (eye worm) hypothetical protein 0.0149 0.0878 0.1469
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0209 0.0311
Echinococcus multilocularis cpg binding protein 0.0124 0.0701 0.0699
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0042 0.0042
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0146 0.0853 0.1272
Schistosoma mansoni inositol monophosphatase 0.0039 0.009 0.0087
Plasmodium vivax metacaspase 1, putative 0.0226 0.1431 0.4463
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0471 0.3184 0.947
Onchocerca volvulus 0.0079 0.0378 0.0538
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0163 0.0244
Mycobacterium ulcerans beta-lactamase 0.0079 0.0378 0.093
Echinococcus multilocularis survival motor neuron protein 1 0.0248 0.1587 0.1585
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.1548 0.2614
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.009 0.0343
Echinococcus granulosus caspase 3 0.0372 0.2473 0.2471
Schistosoma mansoni inositol monophosphatase 0.0039 0.009 0.0087
Onchocerca volvulus 0.0147 0.0861 0.126
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0147 0.0861 0.0858
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.0415 0.0593
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0031 0.0037 0.0035
Brugia malayi CHD4 protein 0.0031 0.0037 0.0033
Brugia malayi Probable ClpP-like protease 0.0471 0.3184 0.5408
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0415 0.0618
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0378 0.093
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0098 0.0096
Mycobacterium ulcerans hypothetical protein 0.0079 0.0378 0.093
Plasmodium vivax SET domain protein, putative 0.0124 0.0697 0.2146
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0372 0.053
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0297 0.0295
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.009 0.0216
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0236 0.0373
Echinococcus multilocularis microtubule associated protein 2 0.1412 0.9912 0.9912
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0297 0.2025
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0372 0.0555
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0075 0.0072
Loa Loa (eye worm) hypothetical protein 0.0042 0.011 0.0157
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0218 0.1373 0.1371
Plasmodium vivax importin-beta 2, putative 0.0034 0.0055 0.0118
Trichomonas vaginalis glucosylceramidase, putative 0.0534 0.3633 0.5416
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0124 0.0697 0.0695
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0378 0.2592
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0049 0.0163 0.0244
Schistosoma mansoni hypothetical protein 0.0384 0.2557 0.2555
Echinococcus multilocularis peregrin 0.0031 0.0035 0.0033
Trichomonas vaginalis glucosylceramidase, putative 0.0534 0.3633 0.5416
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0485 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0077 0.0114
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0309 0.2023 0.5857
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0378 0.0563
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.027 0.0581
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0042 0.004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.004 0.01 0.0098
Echinococcus multilocularis expressed protein 0.0451 0.3036 0.3034
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0378 0.093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0178 0.1083 0.1819
Echinococcus granulosus chromobox protein 1 0.014 0.0811 0.0809
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0162 0.0974 0.302
Schistosoma mansoni caspase-7 (C14 family) 0.0598 0.4092 0.409
Schistosoma mansoni peptidase Clp (S14 family) 0.0471 0.3184 0.3183
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1431 0.2133
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0378 0.0563
Loa Loa (eye worm) hypothetical protein 0.0141 0.0822 0.1373
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0162 0.0974 0.2924
Brugia malayi SET domain containing protein 0.003 0.0026 0.0014
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0042 0.0232
Brugia malayi hypothetical protein 0.0149 0.0878 0.1469
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0058 0.0225 0.0223
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0218 0.1373 0.1371
Brugia malayi Pre-SET motif family protein 0.0124 0.0697 0.1161
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0297 0.1835
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0049 0.0163 0.0244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0288 0.187 0.2788
Schistosoma mansoni hypothetical protein 0.0058 0.0225 0.0223
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0218 0.1373 0.1371
Brugia malayi PHD-finger family protein 0.0032 0.0041 0.004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Brugia malayi Melibiase family protein 0.0146 0.0853 0.1427
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0297 0.1547
Echinococcus multilocularis regulator of G protein signaling 7 0.0042 0.0115 0.0113
Schistosoma mansoni importin beta-1 0.0034 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0079 0.0378 0.0615
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0031 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0039 0.0092 0.0127
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0534 0.3633 0.6174
Trichomonas vaginalis conserved hypothetical protein 0.0226 0.1431 0.2133
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.0024 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0042 0.004
Echinococcus multilocularis Protein lozenge 0.0058 0.0229 0.0227
Onchocerca volvulus 0.0079 0.0378 0.0538
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0146 0.0853 0.0851
Schistosoma mansoni regulator of G protein signaling 0.0042 0.0115 0.0113
Plasmodium vivax ataxin-2 like protein, putative 0.0129 0.0733 0.2258
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.027 0.0673
Echinococcus granulosus jumonji domain containing protein 0.004 0.0098 0.0096
Loa Loa (eye worm) hypothetical protein 0.0079 0.0378 0.0615
Toxoplasma gondii LsmAD domain-containing protein 0.0129 0.0733 0.2138
Brugia malayi jmjC domain containing protein 0.0043 0.0122 0.0178
Loa Loa (eye worm) hypothetical protein 0.0078 0.0372 0.0606
Trichomonas vaginalis glucosylceramidase, putative 0.0534 0.3633 0.5416
Trichomonas vaginalis glucosylceramidase, putative 0.035 0.2319 0.3457
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0042 0.004
Schistosoma mansoni cpg binding protein 0.0124 0.0701 0.0699
Loa Loa (eye worm) hypothetical protein 0.0034 0.0055 0.0064
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0378 0.0615
Brugia malayi follicle stimulating hormone receptor 0.0248 0.1586 0.2679
Schistosoma mansoni hypothetical protein 0.0029 0.0018 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0378 0.0563
Schistosoma mansoni hypothetical protein 0.0211 0.132 0.1318
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0031 0.0037 0.0035
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0464 0.0762
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.027 0.1833
Echinococcus granulosus apoptotic protease activating factor 1 0.0211 0.132 0.1318
Toxoplasma gondii melibiase subfamily protein 0.0218 0.1373 0.4054
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0061 0.0058
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.0024 0.0022
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0165 0.0996 0.167
Echinococcus multilocularis caspase 2 0.0437 0.2938 0.2937
Echinococcus multilocularis histone acetyltransferase MYST2 0.0165 0.0996 0.0993
Brugia malayi isocitrate dehydrogenase 0.0032 0.0042 0.0042
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 1
Treponema pallidum fructose-bisphosphate aldolase 0.0288 0.187 0.4052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0464 0.0762
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0378 0.0563
Leishmania major hypothetical protein, conserved 0.0079 0.0378 0.2592
Trypanosoma cruzi metacaspase, putative 0.0226 0.1431 1
Mycobacterium tuberculosis Conserved protein 0.0079 0.0378 0.0992
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0218 0.1373 0.1371
Echinococcus granulosus peptidase Clp S14 family 0.0309 0.2023 0.2021
Echinococcus granulosus microtubule associated protein 2 0.1412 0.9912 0.9912
Loa Loa (eye worm) inositol-1 0.0039 0.009 0.0123
Loa Loa (eye worm) hypothetical protein 0.0079 0.0378 0.0615
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.009 0.0087
Schistosoma mansoni hypothetical protein 0.1424 1 1
Plasmodium vivax hypothetical protein, conserved 0.0226 0.1431 0.4463
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0117 0.0647 0.0645
Brugia malayi Importin beta-1 subunit 0.0034 0.0055 0.0064
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0378 0.1015
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0042 0.0232
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0248 0.1586 0.2679
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0122 0.012
Schistosoma mansoni caspase-3 (C14 family) 0.0598 0.4092 0.409
Mycobacterium tuberculosis Conserved protein 0.0079 0.0378 0.0992
Schistosoma mansoni myelin transcription factor 1 myt1 0.0165 0.0996 0.0993
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0226 0.1431 0.1429
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0471 0.3184 0.5
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0471 0.3184 0.947
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0561 0.3827 0.6506
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0288 0.187 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0087 0.0433 0.2276
Plasmodium falciparum metacaspase-like protein 0.0226 0.1431 0.4463
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.027 0.0267
Onchocerca volvulus 0.0145 0.0852 0.1247
Echinococcus granulosus mixed lineage leukemia protein mll 0.0033 0.005 0.0047
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0598 0.4092 0.409
Schistosoma mansoni sex comb on midleg homolog 0.0145 0.0852 0.085
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0033 0.005 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0561 0.3827 0.6506
Toxoplasma gondii hypothetical protein 0.0162 0.0974 0.286
Brugia malayi hypothetical protein 0.0083 0.0407 0.0664
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0226 0.1431 0.2133
Brugia malayi Heterochromatin protein 1 0.014 0.0811 0.1355

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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