Detailed information for compound 586209

Basic information

Technical information
  • TDR Targets ID: 586209
  • Name: 4,6a,7,12-tetrahydroxy-8-methoxy-3-methyl-2,3 ,4,7,12,12a-hexahydrobenzo[a]anthracen-1-one
  • MW: 358.385 | Formula: C20H22O6
  • H donors: 4 H acceptors: 5 LogP: -0.89 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1C(O)C1(C(C2O)C2=C(C=C1)C(C(CC2=O)C)O)O
  • InChi: 1S/C20H22O6/c1-9-8-12(21)14-11(17(9)22)6-7-20(25)16(14)18(23)10-4-3-5-13(26-2)15(10)19(20)24/h3-7,9,16-19,22-25H,8H2,1-2H3
  • InChiKey: XMXBNUIKCGPIAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • X-14881D
  • 4,6a,7,12-tetrahydroxy-8-methoxy-3-methyl-2,3,4,7,12,12a-hexahydrobenzo[c]anthracen-1-one
  • 85178-52-5
  • 3,4,6a,7,12,12a-Hexahydro-4,6a,7,12-tetrahydroxy-8-methoxy-3-methylbenz(a)anthracen-1(2H)-one
  • Benz(a)anthracen-1(2H)-one, 3,4,6a,7,12,12a-hexahydro-4,6a,7,12-tetrahydroxy-8-methoxy-3-methyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0017
Echinococcus granulosus neuropeptide FF receptor 2 0.0457 0.1054 0.1754
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0473 0.1092 0.1816
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0021 0.0021
Brugia malayi follicle stimulating hormone receptor 0.0457 0.1054 0.104
Onchocerca volvulus 0.0457 0.1054 0.1725
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0069 0.0138 0.3987
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0032
Brugia malayi flavodoxin family protein 0.0046 0.0083 0.0067
Giardia lamblia Alanyl dipeptidyl peptidase 0.0038 0.0063 0.8374
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0457 0.1054 0.1753
Brugia malayi Tachykinin-like peptides receptor 99D 0.0457 0.1054 0.104
Onchocerca volvulus 0.0457 0.1054 0.1725
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0457 0.1054 0.1735
Brugia malayi vesicular acetylcholine transporter unc-17 0.2556 0.6007 0.6001
Brugia malayi prolyl oligopeptidase family protein 0.0038 0.0063 0.0047
Trypanosoma brucei THT1 - hexose transporter, putative 0.002 0.0021 0.0005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0076 0.0075
Schistosoma mansoni glucose transport protein 0.0063 0.0124 0.0183
Schistosoma mansoni brg-1 associated factor 0.0069 0.0138 0.0207
Leishmania major glucose transporter, lmgt3 0.002 0.0021 0.0005
Echinococcus multilocularis zinc finger protein Ran binding 0.0025 0.0033 0.0053
Onchocerca volvulus 0.0025 0.0033 0.0019
Echinococcus multilocularis fmrfamide receptor 0.0457 0.1054 0.1753
Schistosoma mansoni memapsin-2 (A01 family) 0.1611 0.3777 0.6278
Schistosoma mansoni biogenic amine receptor 0.0457 0.1054 0.1735
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0046 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0032
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0017
Trichomonas vaginalis glucose transporter, putative 0.002 0.0021 0.0325
Schistosoma mansoni RNA binding protein 0.0025 0.0033 0.0031
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0038 0.0063 0.0082
Schistosoma mansoni amine GPCR 0.0457 0.1054 0.1735
Schistosoma mansoni neuropeptide F-like receptor 0.0457 0.1054 0.1735
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0457 0.1054 0.1735
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0473 0.1092 0.1815
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0154 1
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Onchocerca volvulus 0.0076 0.0154 0.0222
Brugia malayi prolyl oligopeptidase family protein 0.0038 0.0063 0.0047
Echinococcus granulosus methionine synthase reductase 0.0028 0.0041 0.0068
Trypanosoma cruzi prolyl endopeptidase 0.0038 0.0063 0.0063
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0457 0.1054 0.1753
Trypanosoma brucei protein kinase, putative 0.0041 0.0072 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0325
Entamoeba histolytica prolyl oligopeptidase family protein 0.0038 0.0063 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0148 0.0323 0.0535
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0021 0.0024 0.0038
Schistosoma mansoni hypothetical protein 0.0351 0.0803 0.1316
Schistosoma mansoni neuropeptide receptor 0.0457 0.1054 0.1735
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0019
Echinococcus granulosus muscleblind protein 0.0155 0.0341 0.0567
Echinococcus granulosus sex peptide receptor 0.0457 0.1054 0.1754
Loa Loa (eye worm) brahma associated protein 0.0069 0.0138 0.0138
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0018
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) calcium channel 0.0052 0.0098 0.0097
Mycobacterium ulcerans lipase LipD 0.0076 0.0154 1
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0457 0.1054 0.104
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0023 0.0007
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Schistosoma mansoni neuropeptide receptor 0.0457 0.1054 0.1735
Echinococcus multilocularis SWI:SNF matrix associated 0.0069 0.0138 0.0228
Trypanosoma cruzi hexose transporter 0.002 0.0021 0.0021
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0154 0.1228
Mycobacterium tuberculosis Conserved protein 0.0076 0.0154 0.1228
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0069 0.0138 0.3987
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0457 0.1054 0.1753
Mycobacterium tuberculosis Probable peptidase 0.0038 0.0063 0.0401
Loa Loa (eye worm) hypothetical protein 0.054 0.1249 0.1248
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0205
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0046 0.0083 0.0067
Schistosoma mansoni amine GPCR 0.0457 0.1054 0.1735
Trichomonas vaginalis sulfite reductase, putative 0.0046 0.0083 0.2304
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0052 0.0098 0.0161
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0457 0.1054 0.1753
Schistosoma mansoni intermediate filament proteins 0.002 0.0021 0.0012
Echinococcus granulosus serotonin receptor 0.0457 0.1054 0.1754
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0041 0.007 0.191
Mycobacterium ulcerans hypothetical protein 0.0076 0.0154 1
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2556 0.6007 0.6007
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0019 0.0615
Onchocerca volvulus 0.0068 0.0134 0.0188
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0052 0.0098 0.0082
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Brugia malayi prolyl oligopeptidase family protein 0.0473 0.1092 0.1077
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Leishmania major cytochrome P450 reductase, putative 0.0041 0.007 0.0054
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0154 0.1228
Echinococcus multilocularis GPCR, family 2 0.0043 0.0076 0.0124
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0025 0.0033 0.0551
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0033 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0124 0.3624
Echinococcus granulosus lamin 0.002 0.0021 0.0035
Giardia lamblia Alanyl dipeptidyl peptidase 0.0038 0.0063 0.8374
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0148 0.0323 0.0322
Onchocerca volvulus 0.0084 0.0172 0.0252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0154 0.0234
Toxoplasma gondii flavodoxin domain-containing protein 0.0023 0.0028 0.0794
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0033 0.0033
Trypanosoma brucei C-8 sterol isomerase, putative 0.4248 1 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0076 0.0124
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.0526
Schistosoma mansoni hypothetical protein 0.0069 0.0138 0.0207
Onchocerca volvulus 0.0457 0.1054 0.1725
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0457 0.1054 0.104
Loa Loa (eye worm) prolyl oligopeptidase 0.0038 0.0063 0.0063
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0018 0.0016 0.0166
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0457 0.1054 0.1753
Mycobacterium tuberculosis Conserved protein 0.0076 0.0154 0.1228
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0457 0.1054 0.104
Schistosoma mansoni hypothetical protein 0.0043 0.0076 0.0102
Onchocerca volvulus 0.0457 0.1054 0.1725
Brugia malayi G protein-coupled receptor F59B2.13 0.0457 0.1054 0.104
Echinococcus granulosus g protein coupled receptor 0.0457 0.1054 0.1754
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0033 0.0017
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0032 0.005 0.005
Plasmodium vivax aspartyl protease, putative 0.0084 0.0172 0.509
Trypanosoma cruzi oligopeptidase b 0.0038 0.0063 0.0063
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0154 0.0255
Echinococcus multilocularis SWI:SNF matrix associated 0.0069 0.0138 0.0228
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0038 0.0063 0.0047
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0095
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0457 0.1054 0.1735
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0457 0.1054 0.1054
Schistosoma mansoni cathepsin D (A01 family) 0.031 0.0707 0.1156
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0022 0.0027 0.0044
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0072 0.1955
Onchocerca volvulus 0.0457 0.1054 0.1725
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0041 0.0072 0.0056
Echinococcus multilocularis dro:myosuppressin receptor 0.0457 0.1054 0.1753
Echinococcus multilocularis orexin receptor type 2 0.0457 0.1054 0.1753
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0205
Schistosoma mansoni lamin 0.002 0.0021 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0063 0.168
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0069 0.0138 0.0138
Onchocerca volvulus Neuropeptide F receptor homolog 0.0457 0.1054 0.1725
Loa Loa (eye worm) FAD binding domain-containing protein 0.0028 0.0041 0.0041
Echinococcus multilocularis neuropeptide receptor 0.0545 0.126 0.2095
Echinococcus multilocularis voltage dependent calcium channel 0.0052 0.0098 0.0161
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0154 0.1228
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Toxoplasma gondii aldehyde dehydrogenase 0.0043 0.0075 0.2133
Onchocerca volvulus 0.0457 0.1054 0.1725
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0046 0.0083 0.0083
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0457 0.1054 0.1753
Plasmodium vivax plasmepsin V, putative 0.0084 0.0172 0.509
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0075 0.4821
Echinococcus multilocularis vesicular acetylcholine transporter 0.2556 0.6007 1
Onchocerca volvulus 0.0076 0.0154 0.0222
Toxoplasma gondii facilitative glucose transporter GT1 0.0063 0.0124 0.3528
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2556 0.6007 1
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.1054 0.1753
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0473 0.1092 0.1788
Loa Loa (eye worm) aspartyl protease 6 0.0084 0.0172 0.0172
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.1054 0.1753
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Brugia malayi beta-lactamase 0.0076 0.0154 0.0139
Brugia malayi beta-lactamase family protein 0.0076 0.0154 0.0139
Echinococcus granulosus peptide allatostatin:somatostatin 0.0457 0.1054 0.1754
Trypanosoma cruzi p450 reductase, putative 0.0046 0.0083 0.0083
Brugia malayi ORL1-like opioid receptor 0.0457 0.1054 0.104
Brugia malayi hypothetical protein 0.0084 0.0172 0.0156
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0046 0.0083 0.0136
Loa Loa (eye worm) hypothetical protein 0.2171 0.5099 0.5098
Giardia lamblia Hypothetical protein 0.0041 0.007 0.9736
Echinococcus granulosus alpha 1A adrenergic receptor 0.0457 0.1054 0.1754
Brugia malayi Eukaryotic aspartyl protease family protein 0.0084 0.0172 0.0156
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0457 0.1054 0.1754
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni cytochrome P450 reductase 0.0046 0.0083 0.0114
Brugia malayi sulfakinin receptor protein 0.0457 0.1054 0.104
Echinococcus granulosus neuropeptide receptor 0.0457 0.1054 0.1754
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0159 0.035 0.0335
Leishmania major oligopeptidase b 0.0038 0.0063 0.0047
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0025 0.0033 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0069 0.0138 0.3987
Brugia malayi FAD binding domain containing protein 0.0046 0.0083 0.0067
Plasmodium vivax hexose transporter 0.0063 0.0124 0.3516
Loa Loa (eye worm) hypothetical protein 0.4248 1 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0204
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0154 0.4605
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0457 0.1054 0.1725
Brugia malayi neuropeptide F receptor 0.0457 0.1054 0.104
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Toxoplasma gondii ran binding protein 0.0025 0.0033 0.0926
Echinococcus granulosus dro:myosuppressin receptor 0.0457 0.1054 0.1754
Plasmodium falciparum plasmepsin IX 0.0084 0.0172 0.509
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0052 0.0098 0.0162
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0204
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Echinococcus granulosus neuropeptides capa receptor 0.0457 0.1054 0.1754
Brugia malayi aspartic protease BmAsp-2, identical 0.0084 0.0172 0.0156
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0019 0.1156
Trichomonas vaginalis esterase, putative 0.0076 0.0154 0.4605
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0041 0.0072 0.0072
Brugia malayi hypothetical protein 0.0084 0.0172 0.0156
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0038 0.0063 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0033 0.0033
Brugia malayi putative neuropeptide receptor 0.0457 0.1054 0.104
Loa Loa (eye worm) TYRA-2 protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0154 0.0154
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0052 0.0098 0.0162
Trypanosoma brucei glucose transporter 1E 0.002 0.0021 0.0005
Echinococcus granulosus Zinc finger RanBP2 type 0.0025 0.0033 0.0054
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni hypothetical protein 0.0025 0.0033 0.0031
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0155 0.0341 0.0341
Echinococcus granulosus SWI:SNF matrix associated 0.0069 0.0138 0.0229
Schistosoma mansoni neuropeptide receptor 0.0457 0.1054 0.1735
Echinococcus multilocularis SWI:SNF matrix associated 0.0069 0.0138 0.0228
Echinococcus multilocularis mitogen activated protein kinase 3 0.0041 0.0072 0.0118
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0154 0.1228
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0043 0.0075 0.0124
Brugia malayi SWIB/MDM2 domain containing protein 0.0069 0.0138 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0072 0.1955
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0148 0.0323 0.0515
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0041 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0043 0.0076 0.0102
Brugia malayi Dopamine receptor 0.0457 0.1054 0.104
Echinococcus multilocularis lamin 0.002 0.0021 0.0034
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Entamoeba histolytica hypothetical protein, conserved 0.0038 0.0063 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0457 0.1054 0.1754
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0154 0.4513
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0457 0.1054 0.1753
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0457 0.1054 0.1735
Brugia malayi Pepsin A precursor 0.0084 0.0172 0.0156
Schistosoma mansoni biogenic amine (5HT) receptor 0.0457 0.1054 0.1735
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0032 0.005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0063
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0021 0.0005
Echinococcus multilocularis acylamino acid releasing enzyme 0.0038 0.0063 0.0103
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0084 0.0172 0.0172
Brugia malayi larval opioid receptor 0.0457 0.1054 0.104
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Schistosoma mansoni opsin-like receptor 0.0457 0.1054 0.1735
Onchocerca volvulus 0.0457 0.1054 0.1725
Chlamydia trachomatis SWIB complex protein 0.0069 0.0138 1
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0018 0.0016 0.0016
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0457 0.1054 0.1735
Schistosoma mansoni hypothetical protein 0.0287 0.0651 0.1062
Echinococcus multilocularis methionine synthase reductase 0.0028 0.0041 0.0067
Brugia malayi brahma associated protein 60 kDa 0.0069 0.0138 0.0122
Brugia malayi AKH receptor 0.0457 0.1054 0.104
Trypanosoma brucei THT1 - hexose transporter, putative 0.002 0.0021 0.0005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.1123 1
Schistosoma mansoni amine GPCR 0.0457 0.1054 0.1735
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0154
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0457 0.1054 0.1754
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Schistosoma mansoni histamine h1 receptor 0.0457 0.1054 0.1735
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0038 0.0063 0.4046
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0046 0.0083 0.0136
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0148 0.0323 0.9216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Leishmania major glucose transporter, lmgt1 0.002 0.0021 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0032
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0019 0.5
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni zinc finger protein 0.0025 0.0033 0.0031
Plasmodium vivax aspartyl proteinase, putative 0.0084 0.0172 0.509
Brugia malayi prolyl oligopeptidase family protein 0.0038 0.0063 0.0047
Brugia malayi intermediate filament protein 0.002 0.0021 0.0005
Schistosoma mansoni glucose transport protein 0.0063 0.0124 0.0183
Trichomonas vaginalis sugar transporter, putative 0.002 0.0021 0.0325
Echinococcus multilocularis mitogen activated protein kinase 0.0041 0.0072 0.0118
Leishmania major glucose transporter/membrane transporter D2, putative 0.002 0.0021 0.0005
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0033 0.0017
Echinococcus multilocularis serotonin receptor 0.054 0.1249 0.2077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0076 0.0125
Brugia malayi hypothetical protein 0.0122 0.0262 0.0246
Echinococcus granulosus survival motor neuron protein 1 0.0267 0.0604 0.1005
Echinococcus granulosus tachykinin peptides receptor 99D 0.0457 0.1054 0.1754
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0154
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0046 0.0083 0.0067
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0473 0.1092 0.1797
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0018 0.0016 0.0016
Echinococcus granulosus g protein coupled receptor 0.0457 0.1054 0.1754
Schistosoma mansoni neuropeptide f receptor 76f 0.0457 0.1054 0.1735
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Leishmania major hypothetical protein, conserved 0.0076 0.0154 0.0139
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0076 0.0125
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0457 0.1054 0.1753
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0018 0.0016 0.0166
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0205
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0154 1
Onchocerca volvulus 0.0054 0.0103 0.0136
Brugia malayi putative neuropeptide receptor NPR1 0.0457 0.1054 0.104
Echinococcus multilocularis voltage dependent calcium channel 0.0052 0.0098 0.0161
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.1593 0.3734 0.3733
Leishmania major glucose transporter, lmgt2 0.002 0.0021 0.0005
Schistosoma mansoni opsin-like receptor 0.0457 0.1054 0.1735
Trypanosoma brucei prolyl oligopeptidase, putative 0.0038 0.0063 0.0047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0457 0.1054 0.1735
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0025 0.0033 0.0053
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) FAD binding domain-containing protein 0.0046 0.0083 0.0082
Schistosoma mansoni hypothetical protein 0.0054 0.0103 0.0148
Echinococcus granulosus biogenic amine 5HT receptor 0.0457 0.1054 0.1754
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0052 0.0098 0.014
Toxoplasma gondii aspartyl protease ASP3 0.0084 0.0172 0.4909
Echinococcus multilocularis neuropeptide Y receptor 0.0457 0.1054 0.1753
Onchocerca volvulus 0.0457 0.1054 0.1725
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0457 0.1054 0.1054
Onchocerca volvulus 0.0025 0.0033 0.0019
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni hypothetical protein 0.0351 0.0803 0.1316
Plasmodium falciparum nitric oxide synthase, putative 0.0046 0.0083 0.2174
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Toxoplasma gondii hypothetical protein 0.0038 0.0063 0.1793
Toxoplasma gondii flavodoxin domain-containing protein 0.0023 0.0028 0.0794
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0084 0.0172 0.4909
Plasmodium falciparum plasmepsin VII 0.0084 0.0172 0.509
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Echinococcus granulosus microtubule associated protein 2 0.0682 0.1584 0.2636
Echinococcus multilocularis microtubule associated protein 2 0.0682 0.1584 0.2635
Echinococcus granulosus allatostatin A receptor 0.0457 0.1054 0.1754
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0052 0.0098 0.0161
Loa Loa (eye worm) hypothetical protein 0.0122 0.0262 0.0261
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0457 0.1054 0.1754
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Loa Loa (eye worm) beta-lactamase 0.0076 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0267 0.0604 0.0604
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0143 0.0313 0.0498
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0043 0.0075 0.0509
Echinococcus multilocularis geminin 0.0351 0.0803 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0138 0.4087
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0038 0.0063 1
Echinococcus granulosus General substrate transporter 0.0054 0.0103 0.017
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0021 0.0024 0.0039
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0259
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0457 0.1054 0.1735
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0135 0.0293 0.0293
Plasmodium falciparum plasmepsin V 0.0084 0.0172 0.509
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0038 0.0063 1
Brugia malayi aspartic protease BmAsp-1, identical 0.0084 0.0172 0.0156
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0041 0.0072 0.0056
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0046 0.0083 0.0067
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0052 0.0098 0.0097
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0038 0.0063 0.0063
Echinococcus granulosus intermediate filament protein 0.002 0.0021 0.0035
Brugia malayi Sugar transporter family protein 0.0063 0.0124 0.0108
Schistosoma mansoni neuropeptide receptor 0.0545 0.126 0.2078
Loa Loa (eye worm) flavodoxin family protein 0.0018 0.0016 0.0015
Schistosoma mansoni hypothetical protein 0.0457 0.1054 0.1735
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0075 0.4821
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni biogenic amine receptor 0.0457 0.1054 0.1735
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0457 0.1054 0.1754
Echinococcus multilocularis g protein coupled receptor 0.0457 0.1054 0.1753
Brugia malayi G protein-coupled receptor 0.0457 0.1054 0.104
Loa Loa (eye worm) hypothetical protein 0.0046 0.0083 0.0082
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0072 0.1955
Schistosoma mansoni biogenic amine receptor 0.0457 0.1054 0.1735
Schistosoma mansoni hypothetical protein 0.0457 0.1054 0.1735
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0021 0.0325
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.1593 0.3734 0.3733
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0032
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0038 0.0063 0.0082
Echinococcus multilocularis neuropeptide Y receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Echinococcus multilocularis sodium channel protein 0.0022 0.0027 0.0043
Brugia malayi Muscleblind-like protein 0.0155 0.0341 0.0326
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0014 0.0023
Trypanosoma cruzi C-8 sterol isomerase, putative 0.4248 1 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0069 0.0138 0.3941
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0063 0.0124 0.0204
Onchocerca volvulus 0.0457 0.1054 0.1725
Trypanosoma cruzi hexose transporter, putative 0.002 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0044 0.0078 0.0107
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0076 0.006
Echinococcus granulosus g-protein coupled receptor 0.0457 0.1054 0.1754
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0041 0.0072 0.0071
Onchocerca volvulus 0.0457 0.1054 0.1725
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0038 0.0063 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0021 0.0021
Echinococcus granulosus lamin dm0 0.002 0.0021 0.0035
Onchocerca volvulus 0.0457 0.1054 0.1725
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Trypanosoma cruzi hexose transporter, putative 0.002 0.0021 0.0021
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0069 0.0138 0.0228
Onchocerca volvulus 0.0025 0.0033 0.0019
Echinococcus granulosus geminin 0.0351 0.0803 0.1336
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0017
Schistosoma mansoni cpg binding protein 0.0071 0.0143 0.0215
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Schistosoma mansoni hypothetical protein 0.0063 0.0124 0.0183
Onchocerca volvulus 0.0457 0.1054 0.1725
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0046 0.0083 0.2174
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0043 0.0075 0.0123
Schistosoma mansoni myosin xvIII 0.0457 0.1054 0.1735
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0063
Plasmodium vivax aspartyl proteinase, putative 0.0148 0.0323 1
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0075 0.0101
Toxoplasma gondii ABC1 family protein 0.0076 0.0154 0.4403
Brugia malayi brahma associated protein 60 kDa 0.0069 0.0138 0.0122
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0052 0.0098 0.0161
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0038 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0154
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0457 0.1054 0.1735
Echinococcus granulosus g protein coupled receptor 0.0457 0.1054 0.1754
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0025 0.0033 0.0033
Echinococcus multilocularis allatostatin A receptor 0.0457 0.1054 0.1753
Schistosoma mansoni survival motor neuron protein 0.0054 0.0103 0.0148
Mycobacterium ulcerans aldehyde dehydrogenase 0.0043 0.0075 0.4821
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0154 0.4605
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0159 0.035 0.0335
Schistosoma mansoni hypothetical protein 0.0457 0.1054 0.1735
Trichomonas vaginalis glucose transporter, putative 0.002 0.0021 0.0325
Echinococcus granulosus hypothetical protein 0.0457 0.1054 0.1754
Schistosoma mansoni neuropeptide F-like receptor 0.0457 0.1054 0.1735
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.0019
Onchocerca volvulus 0.0457 0.1054 0.1725
Toxoplasma gondii aspartyl protease 0.0084 0.0172 0.4909
Loa Loa (eye worm) hypothetical protein 0.0148 0.0323 0.0322
Plasmodium falciparum plasmepsin X 0.0084 0.0172 0.509
Echinococcus multilocularis g protein coupled receptor 0.0457 0.1054 0.1753
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0063 0.0063
Plasmodium vivax aspartyl protease, putative 0.0084 0.0172 0.509
Mycobacterium ulcerans beta-lactamase 0.0076 0.0154 1
Schistosoma mansoni diflavin oxidoreductase 0.0023 0.0028 0.0023
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Plasmodium falciparum peptidase, putative 0.0038 0.0063 0.1539
Echinococcus granulosus cpg binding protein 0.0071 0.0143 0.0238
Mycobacterium tuberculosis Conserved protein 0.0076 0.0154 0.1228
Plasmodium falciparum plasmepsin VI 0.0148 0.0323 1
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0025 0.0033 0.0054
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0052 0.0098 0.0162
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0076 0.0124
Brugia malayi beta-lactamase family protein 0.0076 0.0154 0.0139
Echinococcus granulosus fmrfamide receptor 0.0457 0.1054 0.1754
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0154 0.0139
Echinococcus multilocularis fmrfamide receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0457 0.1054 0.104
Loa Loa (eye worm) sugar transporter 0.0063 0.0124 0.0123
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0018 0.0016 0.0166
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0069 0.0138 0.3987
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0038 0.0063 0.0047
Loa Loa (eye worm) hypothetical protein 0.0043 0.0076 0.0075
Trypanosoma brucei THT1 - hexose transporter, putative 0.002 0.0021 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0457 0.1054 0.1735
Echinococcus granulosus mitogen activated protein kinase 0.0041 0.0072 0.0119
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0457 0.1054 0.1753
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0038 0.0063 0.0082
Loa Loa (eye worm) hypothetical protein 0.0038 0.0063 0.0063
Echinococcus multilocularis neuropeptide FF receptor 2 0.0457 0.1054 0.1753
Loa Loa (eye worm) histone methyltransferase 0.0021 0.0024 0.0024
Echinococcus multilocularis sex peptide receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Echinococcus multilocularis neuropeptide receptor 0.0457 0.1054 0.1753
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0069 0.0138 0.3941
Brugia malayi hypothetical protein 0.0457 0.1054 0.104
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0025 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0154
Echinococcus granulosus synaptic vesicle 2 protein 0.0011 0.0001 0.0001
Leishmania major p450 reductase, putative 0.0046 0.0083 0.0067
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0025 0.0033 0.0033
Schistosoma mansoni glucose transport protein 0.0063 0.0124 0.0183
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0003
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0154 1
Echinococcus multilocularis ring and YY1 binding protein 0.0025 0.0033 0.0053
Trypanosoma cruzi WLM domain containing protein, putative 0.0025 0.0033 0.0033
Brugia malayi G-protein coupled receptor 0.0457 0.1054 0.104
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0018 0.0016 0.0016
Entamoeba histolytica prolyl oligopeptidase family protein 0.0038 0.0063 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0259
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni hypothetical protein 0.0043 0.0076 0.0102
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0063 0.0063
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0205
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0457 0.1054 0.1753
Echinococcus multilocularis neuropeptides capa receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) prolyl oligopeptidase 0.0473 0.1092 0.1091
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0038 0.0063 0.168
Brugia malayi Calcitonin receptor-like protein seb-1 0.0135 0.0293 0.0278
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0043 0.0075 0.0059
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0025 0.0033 0.0019
Schistosoma mansoni hypothetical protein 0.0069 0.0138 0.0207
Brugia malayi Serotonin receptor 0.1434 0.336 0.3349
Plasmodium vivax plasmepsin IV, putative 0.0148 0.0323 1
Echinococcus granulosus tm gpcr rhodopsin 0.0457 0.1054 0.1754
Schistosoma mansoni hypothetical protein 0.0043 0.0076 0.0102
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0076 0.006
Schistosoma mansoni adenoreceptor 0.0457 0.1054 0.1735
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) intermediate filament protein 0.002 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0135 0.0293 0.0293
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0017
Schistosoma mansoni NADPH flavin oxidoreductase 0.0023 0.0029 0.0025
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0148 0.0323 1
Trypanosoma brucei glucose transporter 2A 0.002 0.0021 0.0005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0457 0.1054 0.1735
Echinococcus multilocularis General substrate transporter 0.0054 0.0103 0.0169
Schistosoma mansoni vesicular acetylcholine transporter 0.2556 0.6007 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0038 0.0063 1
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0159 0.035 0.0581
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0046 0.0083 0.5317
Plasmodium vivax aspartyl protease, putative 0.0084 0.0172 0.509
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0038 0.0063 0.0047
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Echinococcus granulosus Dipeptidyl peptidase 9 0.0159 0.035 0.0582
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0154 0.1228
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0154
Echinococcus granulosus 7TM GPCR rhodopsin 0.0457 0.1054 0.1754
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0457 0.1054 0.104
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0052 0.0098 0.014
Echinococcus granulosus neuropeptide Y receptor 0.0457 0.1054 0.1754
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0041 0.0072 0.2039
Onchocerca volvulus 0.0457 0.1054 0.1725
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0046 0.0083 0.0137
Echinococcus multilocularis G protein coupled receptor 139 0.0545 0.126 0.2095
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0159 0.035 0.035
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0038 0.0063 0.168
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0041 0.0072 0.0072
Echinococcus granulosus somatostatin receptor 0.0457 0.1054 0.1754
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0159 0.035 0.056
Echinococcus multilocularis serotonin receptor 0.054 0.1249 0.2077
Brugia malayi Melatonin receptor type 1A 0.0457 0.1054 0.104
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.0014 0.0022
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Echinococcus multilocularis somatostatin receptor 0.0457 0.1054 0.1753
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0025 0.0033 0.0033
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0025 0.0033 0.0926
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0041 0.0072 0.0056
Onchocerca volvulus Prolyl endopeptidase homolog 0.0038 0.0063 0.007
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0041 0.0072 0.0072
Trypanosoma cruzi oligopeptidase b 0.0038 0.0063 0.0063
Onchocerca volvulus 0.0457 0.1054 0.1725
Schistosoma mansoni lamin 0.002 0.0021 0.0012
Loa Loa (eye worm) hypothetical protein 0.0155 0.0341 0.0341
Schistosoma mansoni fusion 0.0025 0.0033 0.0031
Brugia malayi hypothetical protein 0.0267 0.0604 0.0589
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0159 0.035 1
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.1054 0.1754
Echinococcus multilocularis survival motor neuron protein 1 0.0267 0.0604 0.1004
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0457 0.1054 0.1054
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Trypanosoma cruzi WLM domain containing protein, putative 0.0025 0.0033 0.0033
Echinococcus granulosus dnaJ subfamily B 0.0287 0.0651 0.1083
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0025 0.0033 0.0033
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0397 0.0912 0.1517
Echinococcus multilocularis dnaJ subfamily B 0.0287 0.0651 0.1082
Brugia malayi neuropeptide F receptor 0.0457 0.1054 0.104
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0159 0.035 0.035
Schistosoma mansoni TRABID protein (C64 family) 0.0025 0.0033 0.0031
Trypanosoma brucei RNA helicase, putative 0.0044 0.0078 0.0063
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Echinococcus granulosus ring and YY1 binding protein 0.0025 0.0033 0.0054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0084 0.0172 0.0263
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0457 0.1054 0.1735
Schistosoma mansoni voltage-gated cation channel 0.0052 0.0098 0.014
Onchocerca volvulus 0.0457 0.1054 0.1725
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0154 0.0234
Trypanosoma brucei glucose transporter, putative 0.002 0.0021 0.0005
Toxoplasma gondii histone lysine methyltransferase SET1 0.0128 0.0277 0.79
Echinococcus multilocularis muscleblind protein 0.0155 0.0341 0.0566
Loa Loa (eye worm) G-protein coupled receptor 0.0457 0.1054 0.1054
Echinococcus multilocularis muscleblind protein 1 0.0155 0.0341 0.0566
Loa Loa (eye worm) melatonin receptor type 1A 0.0457 0.1054 0.1054
Echinococcus granulosus mitogen activated protein kinase 3 0.0041 0.0072 0.0119
Onchocerca volvulus 0.0076 0.0154 0.0222
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0025 0.0033 0.0017
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0457 0.1054 0.1753
Brugia malayi Dopamine receptor protein 1 0.0457 0.1054 0.104
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0069 0.0138 0.0229
Leishmania major C-8 sterol isomerase-like protein 0.4248 1 1
Onchocerca volvulus 0.0457 0.1054 0.1725
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Loa Loa (eye worm) neuropeptide F receptor 0.0457 0.1054 0.1054
Echinococcus granulosus neuropeptides capa receptor 0.0457 0.1054 0.1754
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0014 0.0022
Plasmodium falciparum plasmepsin IV 0.0148 0.0323 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0018 0.0016 0.0166
Onchocerca volvulus 0.0084 0.0172 0.0252
Schistosoma mansoni growth hormone secretagogue receptor 0.0457 0.1054 0.1735
Echinococcus granulosus biogenic amine 5HT receptor 0.054 0.1249 0.2078
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0063 0.1539
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0033 0.0017
Chlamydia trachomatis DNA topoisomerase I 0.0069 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni biogenic amine (5HT) receptor 0.054 0.1249 0.2059
Echinococcus granulosus acylamino acid releasing enzyme 0.0038 0.0063 0.0104
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Brugia malayi Serotonin receptor 0.0457 0.1054 0.104
Schistosoma mansoni cpg binding protein 0.0068 0.0134 0.02
Plasmodium falciparum plasmepsin I 0.0148 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni alpha-1 adrenergic receptor 0.0457 0.1054 0.1735
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0052 0.0098 0.0161
Echinococcus granulosus neuropeptide receptor 0.0545 0.126 0.2096
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0003
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Schistosoma mansoni aldehyde dehydrogenase 0.0043 0.0075 0.0101
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0025 0.0033 0.0017
Brugia malayi G-protein coupled receptor 0.0457 0.1054 0.104
Echinococcus multilocularis musashi 0.002 0.0021 0.0034
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0038 0.0063 0.1793
Echinococcus multilocularis prolyl endopeptidase 0.0038 0.0063 0.0103
Echinococcus granulosus GPCR family 2 0.0043 0.0076 0.0125
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0038 0.0063 0.0401
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0154 0.4605
Trypanosoma brucei prolyl endopeptidase 0.0038 0.0063 0.0047
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0008
Echinococcus granulosus prolyl endopeptidase 0.0038 0.0063 0.0104
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0159 0.035 0.0335
Echinococcus granulosus orexin receptor type 2 0.0457 0.1054 0.1754
Brugia malayi GnHR receptor homolog 0.0457 0.1054 0.104
Onchocerca volvulus 0.0069 0.0138 0.0195
Plasmodium falciparum hexose transporter 0.0063 0.0124 0.3516
Schistosoma mansoni opsin-like receptor 0.0457 0.1054 0.1735
Loa Loa (eye worm) neuropeptide F receptor 0.0457 0.1054 0.1054
Echinococcus granulosus neuropeptide s receptor 0.0457 0.1054 0.1754
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0046 0.0083 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0068 0.0134 0.0134
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0457 0.1054 0.1054
Plasmodium falciparum plasmepsin VIII, putative 0.0084 0.0172 0.509
Onchocerca volvulus 0.0025 0.0033 0.0019
Echinococcus granulosus vesicular acetylcholine transporter 0.2556 0.6007 1
Plasmodium falciparum plasmepsin III 0.0084 0.0172 0.509
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0028 0.0041 0.0045
Giardia lamblia Nitric oxide synthase, inducible 0.0041 0.007 0.9736
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0457 0.1054 0.1735
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0154 0.0139
Plasmodium falciparum plasmepsin II 0.0148 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0192 0.0192
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0154 0.1228
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Echinococcus granulosus G protein coupled receptor 139 0.0457 0.1054 0.1754
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0046 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0076 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0154 0.1228
Loa Loa (eye worm) hypothetical protein 0.0084 0.0172 0.0172
Trypanosoma brucei oligopeptidase b 0.0038 0.0063 0.0047
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0025 0.0033 0.0033
Brugia malayi RE15519p 0.0457 0.1054 0.104
Brugia malayi YY1-associated factor 2 0.0025 0.0033 0.0017
Echinococcus multilocularis lamin dm0 0.002 0.0021 0.0034
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0046 0.0083 0.0137
Echinococcus granulosus zinc finger protein Ran binding 0.0025 0.0033 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0033 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0135 0.0293 0.0278
Echinococcus multilocularis rhodopsin orphan GPCR 0.0457 0.1054 0.1753
Echinococcus multilocularis g-protein coupled receptor 0.0457 0.1054 0.1753
Echinococcus granulosus neuropeptide Y receptor 0.0457 0.1054 0.1754
Schistosoma mansoni microtubule-associated protein tau 0.0682 0.1584 0.2619
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0046 0.0083 0.0067
Loa Loa (eye worm) G-protein coupled receptor 0.0457 0.1054 0.1054
Schistosoma mansoni amine GPCR 0.0457 0.1054 0.1735
Loa Loa (eye worm) hypothetical protein 0.054 0.1249 0.1248
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0148 0.0323 0.0536
Echinococcus multilocularis G-protein coupled receptor, putative 0.0457 0.1054 0.1753
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0154 0.4605
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0025 0.0033 0.0032
Trypanosoma cruzi hexose transporter, putative 0.002 0.0021 0.0021
Brugia malayi FAD binding domain containing protein 0.0028 0.0041 0.0025
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Toxoplasma gondii prolyl endopeptidase 0.0038 0.0063 0.1793
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Mycobacterium leprae Probable lipase LipE 0.0076 0.0154 1
Trichomonas vaginalis sugar transporter, putative 0.002 0.0021 0.0325
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0457 0.1054 0.1735
Schistosoma mansoni amine GPCR 0.0457 0.1054 0.1735
Brugia malayi MAP kinase sur-1 0.0041 0.0072 0.0056
Schistosoma mansoni hypothetical protein 0.0069 0.0138 0.0207
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0154 0.4605
Echinococcus multilocularis cpg binding protein 0.0071 0.0143 0.0236
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0154 0.0154
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0019 1
Brugia malayi Dopamine receptor protein 2 0.0457 0.1054 0.104
Brugia malayi prolyl oligopeptidase family protein 0.0159 0.035 0.0335
Loa Loa (eye worm) hypothetical protein 0.0457 0.1054 0.1054
Schistosoma mansoni hypothetical protein 0.0092 0.0192 0.0297
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0029
Echinococcus granulosus voltage dependent calcium channel 0.0052 0.0098 0.0162
Brugia malayi CXXC zinc finger family protein 0.0068 0.0134 0.0118
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0063 0.0124 0.0204
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0031
Toxoplasma gondii aspartyl protease ASP1 0.0148 0.0323 0.9216
Trichomonas vaginalis CMGC family protein kinase 0.0041 0.0072 0.1955
Trichomonas vaginalis sugar transporter, putative 0.002 0.0021 0.0325
Schistosoma mansoni cathepsin D (A01 family) 0.031 0.0707 0.1156
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0457 0.1054 0.1054
Giardia lamblia Kinase, CMGC MAPK 0.0041 0.0072 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0457 0.1054 0.1754
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0457 0.1054 0.1735
Schistosoma mansoni hypothetical protein 0.0457 0.1054 0.1735
Plasmodium vivax flavodoxin domain containing protein 0.0041 0.007 0.1774
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.0103 0.0087
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0154 0.0256
Schistosoma mansoni cpg binding protein 0.0071 0.0143 0.0215
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0457 0.1054 0.1754
Brugia malayi latrophilin 2 splice variant baaae 0.0092 0.0192 0.0177
Echinococcus granulosus tm gpcr rhodopsin 0.0457 0.1054 0.1754
Echinococcus multilocularis g protein coupled receptor 0.0457 0.1054 0.1753
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0025 0.0033 0.0017
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0457 0.1054 0.1754
Echinococcus multilocularis neuropeptides capa receptor 0.0457 0.1054 0.1753
Echinococcus granulosus tm gpcr rhodopsin 0.0457 0.1054 0.1754
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0072 0.0096

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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