Detailed information for compound 58919

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.537 | Formula: C24H24N4O3S
  • H donors: 1 H acceptors: 3 LogP: 3.09 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1CC[C@@H]1[C@H]2CN(C1)CCn1c(=O)[nH]c2c(c1=O)sc1c2ccnc1
  • InChi: 1S/C24H24N4O3S/c1-31-19-4-2-3-15-16(19)6-5-14-12-27(13-18(14)15)9-10-28-23(29)22-21(26-24(28)30)17-7-8-25-11-20(17)32-22/h2-4,7-8,11,14,18H,5-6,9-10,12-13H2,1H3,(H,26,30)/t14-,18+/m0/s1
  • InChiKey: DTGRVNYCCXSWCG-KBXCAEBGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Alpha-1d adrenergic receptor Starlite/ChEMBL References
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References
Mesocricetus auratus Alpha-1b adrenergic receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus biogenic amine 5HT receptor Alpha-1a adrenergic receptor   466 aa 418 aa 30.4 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Echinococcus granulosus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 399 aa 20.8 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 398 aa 21.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Alpha-1a adrenergic receptor   466 aa 386 aa 31.6 %
Echinococcus multilocularis neuropeptide Y receptor Alpha-1a adrenergic receptor   466 aa 419 aa 19.6 %
Echinococcus granulosus rhodopsin orphan GPCR Alpha-1a adrenergic receptor   466 aa 418 aa 20.3 %
Echinococcus multilocularis g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.3 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Alpha-1a adrenergic receptor   466 aa 443 aa 31.2 %
Schistosoma japonicum FMRFamide receptor, putative Alpha-1a adrenergic receptor   466 aa 374 aa 19.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0309
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0064 0.0565
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0907 0.2573
Loa Loa (eye worm) hypothetical protein 0.0247 0.1016 0.3469
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.2091 0.7144
Trichomonas vaginalis set domain proteins, putative 0.077 0.3342 1
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0249 0.1023 0.3051
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.0079 0.0078
Toxoplasma gondii endonuclease IV APN 0.0089 0.0311 0.2885
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0155 0.0605 0.0604
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0023 0.0023
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0037 0.0079 0.0223
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0077 0.0256 0.0255
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0167 0.0386
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1098 0.1098
Loa Loa (eye worm) hypothetical protein 0.004 0.0092 0.0312
Loa Loa (eye worm) hypothetical protein 0.0086 0.0298 0.1016
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0168 0.0167
Brugia malayi Metabotropic glutamate receptor precursor. 0.0267 0.1104 0.377
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0223 0.0907 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0042 0.01 0.2861
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.011 0.0405 0.0404
Leishmania major trypanothione reductase 0.0048 0.0125 0.0973
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0094 0.0333 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0091 0.009
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0907 0.2573
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.029
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0087 0.03 0.03
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1098 0.1098
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.1023 0.1022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0098 0.0348 0.0805
Schistosoma mansoni survival motor neuron protein 0.005 0.0138 0.0319
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1023 0.1022
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0256 0.2797
Brugia malayi Kringle domain containing protein 0.0025 0.0023 0.0077
Toxoplasma gondii 6-phosphofructokinase 0.006 0.0182 0.1672
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0091 0.009
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0451 0.4109
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0023 0.0077
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.0211 0.045
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.0079 0.0181
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.018 0.1655
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Schistosoma mansoni regulator of G protein signaling 0.004 0.0091 0.0209
Echinococcus multilocularis lamin dm0 0.0086 0.0298 0.0297
Echinococcus granulosus expressed protein 0.0777 0.3374 0.3373
Echinococcus multilocularis bloom syndrome protein 0.0067 0.0211 0.021
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0178 0.567
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.0079 0.0267
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0067 0.0227
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0037 0.0079 0.0078
Echinococcus granulosus tumor protein p63 0.0364 0.1536 0.1535
Loa Loa (eye worm) hypothetical protein 0.0048 0.0129 0.0439
Entamoeba histolytica hypothetical protein 0.004 0.0091 0.1005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Echinococcus multilocularis voltage dependent calcium channel subunit 0.2265 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.0079 0.0868
Schistosoma mansoni z-protein (S1r protein) 0.004 0.0091 0.0209
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.1023 0.1022
Brugia malayi hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0046 0.0154
Echinococcus granulosus lamin dm0 0.0086 0.0298 0.0297
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.1071 0.2482
Brugia malayi nuclear receptor NHR-88 0.0037 0.0079 0.0267
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0182 0.036
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.006 0.0178 0.9641
Brugia malayi 6-phosphofructokinase 0.0223 0.0907 0.3098
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.0079 0.0181
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.1799 0.1798
Brugia malayi hypothetical protein 0.004 0.0091 0.0309
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0397 0.3597
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0042 0.0101 0.2894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0042 0.0101 0.2894
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0125 0.0125
Schistosoma mansoni metabotropic glutamate receptor 0.0137 0.0524 0.1213
Echinococcus granulosus metabotropic glutamate receptor 2 0.0226 0.092 0.0919
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0907 0.2573
Schistosoma mansoni 6-phosphofructokinase 0.0223 0.0907 0.2102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0099 0.0336
Loa Loa (eye worm) hypothetical protein 0.0326 0.1365 0.4663
Brugia malayi photoreceptor-specific nuclear receptor 0.0037 0.0079 0.0267
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.1071 0.107
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0125 0.1018
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0091 0.009
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.0211 0.0719
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.0079 0.0267
Schistosoma mansoni regulator of G protein signaling 0.004 0.0091 0.0209
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Entamoeba histolytica recQ family DNA helicase 0.002 0.0003 0.0038
Brugia malayi von Willebrand Factor 0.0042 0.0101 0.0341
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0079 0.0266
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.1023 0.1022
Onchocerca volvulus 0.0042 0.0101 0.0289
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0079 0.0078
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0086 0.0085
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0079 0.0266
Leishmania major hypothetical protein, conserved 0.0027 0.0034 0.0105
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0086 0.0085
Schistosoma mansoni tyrosine kinase 0.0037 0.0079 0.0181
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.0079 0.0181
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0086 0.0085
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.0079 0.0078
Loa Loa (eye worm) RecQ helicase 0.0067 0.0211 0.0719
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.095
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0086 0.0946
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0167 0.0167
Echinococcus granulosus receptor type guanylyl cyclase 0.0037 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0078 0.0262 0.0894
Echinococcus granulosus FTZ F1 alpha 0.0037 0.0079 0.0078
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) CUTiclin family member 0.0042 0.0101 0.0341
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0175 0.1893
Trichomonas vaginalis 6-phosphofructokinase, putative 0.006 0.0182 0.036
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0034 0.0115
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0112 0.0111
Brugia malayi laminin alpha chain 0.0048 0.0129 0.0439
Treponema pallidum exodeoxyribonuclease (exoA) 0.006 0.0178 0.0288
Schistosoma mansoni axis inhibition protein axin 0.004 0.0091 0.0209
Brugia malayi Cache domain containing protein 0.0456 0.1944 0.6643
Echinococcus multilocularis 6 phosphofructokinase 0.0223 0.0907 0.0906
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0182 0.036
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.1071 0.2482
Brugia malayi A-kinase anchor protein 10, precursor 0.004 0.0091 0.0309
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0086 0.0595
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0498 0.2132 0.4941
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0079 0.0181
Loa Loa (eye worm) phosphofructokinase 0.0223 0.0907 0.3098
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0155 0.0605 0.0604
Trypanosoma brucei trypanothione reductase 0.0048 0.0125 0.1041
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0042 0.0101 0.01
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0167 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.0079 0.0267
Echinococcus granulosus slit 2 protein 0.0048 0.0129 0.0128
Toxoplasma gondii phosphofructokinase domain-containing protein 0.006 0.0182 0.1672
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.006 0.0178 0.1937
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0067 0.0011
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.1071 0.107
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1386 0.6084 1
Brugia malayi hypothetical protein 0.0037 0.0079 0.0266
Echinococcus granulosus neutral amino acid transporter A 0.0249 0.1023 0.1022
Loa Loa (eye worm) hypothetical protein 0.0041 0.0097 0.0329
Brugia malayi PXA domain containing protein 0.004 0.0091 0.0309
Onchocerca volvulus 0.0042 0.0101 0.0289
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0034 0.0291
Brugia malayi CXXC zinc finger family protein 0.003 0.0046 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.021 0.0485
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0087 0.03 0.03
Echinococcus granulosus nmda type glutamate receptor 0.0045 0.0114 0.0113
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Schistosoma mansoni serine-rich repeat protein 0.0532 0.2283 0.5291
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0042 0.0101 0.314
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0026 0.0028 0.0028
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0167 0.057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0086 0.0067
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.006 0.0178 0.1937
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.0079 0.0223
Loa Loa (eye worm) hypothetical protein 0.0328 0.1376 0.47
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.1071 1
Entamoeba histolytica hypothetical protein 0.0042 0.0101 0.111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Echinococcus granulosus axis inhibition protein axin 0.004 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0012
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.009 0.0305
Schistosoma mansoni coup transcription factor 0.0037 0.0079 0.0181
Brugia malayi Thioredoxin reductase 0.0048 0.0125 0.0426
Schistosoma mansoni lamin 0.0086 0.0298 0.0689
Giardia lamblia Sgs1 DNA helicase, putative 0.004 0.009 0.0438
Brugia malayi Doublecortin family protein 0.002 0.0004 0.0012
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0037 0.0079 0.0266
Mycobacterium tuberculosis Probable reductase 0.0109 0.0397 0.3597
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0199 0.2168
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.004 0.0091 0.0209
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0101 0.0341
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0226 0.092 0.0919
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0101 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0348 0.0805
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0256 0.2541
Echinococcus multilocularis cpg binding protein 0.0031 0.0053 0.0053
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0086 0.0588
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0077 0.0256 0.2797
Entamoeba histolytica hypothetical protein 0.004 0.0091 0.1005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0079 0.0078
Brugia malayi follicle stimulating hormone receptor 0.0489 0.2091 0.7144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0059
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0004 0.0003
Echinococcus multilocularis Excitatory amino acid transporter 0.0249 0.1023 0.1022
Schistosoma mansoni amine GPCR 0.0417 0.1769 0.4101
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0167 0.0167
Brugia malayi Guanylyl cyclase protein 23 0.0037 0.0079 0.0266
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0167 0.0386
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0086 0.0197
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.0079 0.0267
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Loa Loa (eye worm) glutamate receptor 0.01 0.0358 0.1222
Echinococcus multilocularis regulator of G protein signaling 3 0.004 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Toxoplasma gondii microneme protein MIC2 0.0042 0.0101 0.0911
Echinococcus multilocularis excitatory amino acid transporter 2 0.0249 0.1023 0.1022
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.004 0.0091 0.0309
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0167 0.0386
Leishmania major ATP-dependent phosphofructokinase 0.0223 0.0907 0.8435
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.1023 0.1022
Brugia malayi regulator of G-protein signaling rgs-7 0.004 0.0091 0.0309
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0167 0.0386
Loa Loa (eye worm) hypothetical protein 0.0446 0.1899 0.6486
Schistosoma mansoni 6-phosphofructokinase 0.0223 0.0907 0.2102
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0079 0.0078
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0026 0.0028 0.0028
Echinococcus granulosus dnaJ subfamily B 0.0423 0.1799 0.1798
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0089 0.0311 0.8947
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0101 0.111
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.0079 0.0267
Brugia malayi cytoplasmic intermediate filament protein 0.0046 0.012 0.0406
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0086 0.0067
Loa Loa (eye worm) hypothetical protein 0.0048 0.0129 0.0439
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.0079 0.0181
Loa Loa (eye worm) hypothetical protein 0.002 0.0003 0.0009
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0451 0.4109
Onchocerca volvulus 0.0037 0.0079 0.0223
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3652 0.3651
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0309
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0199 0.2168
Echinococcus multilocularis voltage dependent calcium channel subunit 0.103 0.4501 0.45
Echinococcus granulosus ATP dependent DNA helicase Q1 0.004 0.009 0.0089
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.004 0.0091 0.0083
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1264 0.2928
Onchocerca volvulus 0.003 0.0046 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0091 0.0083
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0042 0.0101 0.0911
Brugia malayi hypothetical protein 0.0027 0.0034 0.0115
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.1023 0.1022
Schistosoma mansoni hypothetical protein 0.0042 0.0101 0.0232
Echinococcus multilocularis geminin 0.0175 0.0695 0.0694
Toxoplasma gondii thioredoxin reductase 0.0048 0.0125 0.1142
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0041 0.0097 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.0079 0.0267
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.0079 0.0267
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0086 0.0085
Schistosoma mansoni glutamate receptor NMDA 0.0094 0.0333 0.077
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0309
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.0079 0.0078
Echinococcus granulosus leukotriene A 4 hydrolase 0.0259 0.1067 0.1066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0397 0.3597
Loa Loa (eye worm) excitatory amino acid transporter 0.0249 0.1023 0.3493
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0129 0.0128
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0086 0.0911
Plasmodium vivax SET domain protein, putative 0.0098 0.0348 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0086 0.0085
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0093 0.0329 0.0328
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0086 0.0085
Treponema pallidum 76K protein 0.0042 0.0101 0.016
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0034 0.0343
Echinococcus granulosus collagen alpha 1VII chain 0.0042 0.0101 0.01
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.0079 0.0181
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0101 0.2894
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.009 0.0811
Onchocerca volvulus 0.0042 0.0101 0.0289
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0122
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0199 0.2168
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0086 0.0911
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.004 0.009 0.279
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0004 0.0003
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0988 0.4314 1
Echinococcus granulosus sodium:dicarboxylate symporter 0.0249 0.1023 0.1022
Brugia malayi PXA domain containing protein 0.004 0.0091 0.0309
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0182 0.036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0079 0.0267
Brugia malayi Cytochrome P450 family protein 0.0025 0.0026 0.0087
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0086 0.0197
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0064 0.0668
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0405 0.0937
Schistosoma mansoni hypothetical protein 0.0532 0.2283 0.5291
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0091 0.0209
Brugia malayi Pre-SET motif family protein 0.0098 0.0348 0.1187
Brugia malayi nuclear hormone receptor 0.0037 0.0079 0.0267
Echinococcus granulosus intermediate filament protein 0.0086 0.0298 0.0297
Schistosoma mansoni lamin 0.0086 0.0298 0.0689
Echinococcus multilocularis Protein lozenge 0.0056 0.0162 0.0162
Leishmania major cathepsin L-like protease 0.0064 0.0199 0.1679
Echinococcus granulosus expressed protein 0.0035 0.0067 0.0067
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0199 0.2168
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0018 0.0059
Echinococcus granulosus pikachurin 0.0048 0.0129 0.0128
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0223 0.0907 0.1486
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0037 0.0079 0.0266
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0125 0.0426
Brugia malayi hypothetical protein 0.002 0.0004 0.0012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0451 0.4866
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0086 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0178 0.035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.0079 0.0078
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0223 0.0907 0.8443
Chlamydia trachomatis endonuclease IV 0.0089 0.0311 0.154
Echinococcus granulosus neutral amino acid transporter 0.0249 0.1023 0.1022
Echinococcus multilocularis nmda type glutamate receptor 0.0045 0.0114 0.0113
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0249 0.1023 0.1022
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.006 0.0182 0.2005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0125 0.0423
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0677 0.2927 1
Loa Loa (eye worm) hypothetical protein 0.0446 0.1899 0.6486
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0249 0.1023 0.2369
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0249 0.1023 0.954
Schistosoma mansoni hypothetical protein 0.005 0.0138 0.0319
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0155 0.0605 0.0604
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0125 0.0125
Echinococcus multilocularis lamin 0.0086 0.0298 0.0297
Schistosoma mansoni hypothetical protein 0.0042 0.0101 0.0232
Brugia malayi hypothetical protein 0.0247 0.1016 0.3469
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.1071 1
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.1016 0.1015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0397 0.426
Echinococcus granulosus glutamate receptor subunit protein glur 0.0026 0.0028 0.0028
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.004 0.0091 0.0309
Mycobacterium ulcerans endonuclease IV 0.0089 0.0311 0.2786
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.006 0.0178 0.5127
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0155 0.0605 0.0604
Onchocerca volvulus 0.0053 0.0151 0.0439
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0089 0.0311 0.2786
Loa Loa (eye worm) 6-phosphofructokinase 0.0223 0.0907 0.3098
Entamoeba histolytica hypothetical protein 0.004 0.0091 0.1005
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.004 0.0091 0.0309
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0078 0.0262 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0079 0.0267
Echinococcus granulosus cpg binding protein 0.0031 0.0053 0.0053
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0064 0.0385
Echinococcus multilocularis NMDA receptor 0.0087 0.03 0.03
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0086 0.0298 0.1016
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.0079 0.0078
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0034 0.0982
Plasmodium falciparum thioredoxin reductase 0.0048 0.0125 0.3941
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.004 0.009 0.0089
Brugia malayi hypothetical protein 0.0446 0.1899 0.6486
Schistosoma mansoni regulator of G protein signaling 0.004 0.0091 0.0209
Brugia malayi Zona pellucida-like domain containing protein 0.0042 0.0101 0.0341
Plasmodium vivax thrombospondin-related anonymous protein 0.0042 0.0101 0.2894
Onchocerca volvulus 0.0042 0.0101 0.0289
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.095
Echinococcus granulosus tyrosine kinase 0.0037 0.0079 0.0078
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0089 0.0311 0.1062
Plasmodium falciparum thrombospondin-related anonymous protein 0.0042 0.0101 0.314
Echinococcus granulosus atrial natriuretic peptide receptor 0.0037 0.0079 0.0078
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0091 0.009
Leishmania major cathepsin L-like protease 0.0064 0.0199 0.1679
Schistosoma mansoni regulator of G protein signaling 0.004 0.0091 0.0209
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0091 0.0209
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0397 0.3597
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1023 0.1022
Echinococcus granulosus regulator of G protein signaling 7 0.004 0.0091 0.009
Schistosoma mansoni ap endonuclease 0.006 0.0178 0.0412
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0077 0.0256 0.0873
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0129 0.0439
Schistosoma mansoni hypothetical protein 0.0025 0.0023 0.0052
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0182 0.5226
Brugia malayi phosphofructokinase 0.0223 0.0907 0.3098
Onchocerca volvulus 0.0446 0.1899 0.5675
Echinococcus granulosus regulator of G protein signaling 3 0.004 0.0091 0.009
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0089 0.0311 0.3299
Treponema pallidum hypothetical protein 0.0042 0.0101 0.016
Brugia malayi regulator of G-protein signaling egl-10 0.004 0.0091 0.0309
Schistosoma mansoni intermediate filament proteins 0.0086 0.0298 0.0689
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0086 0.029
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0091 0.0083
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0115 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.0079 0.0267
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0079 0.0181
Echinococcus multilocularis slit 2 protein 0.0048 0.0129 0.0128
Onchocerca volvulus 0.0086 0.0298 0.088
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0168 0.0167
Trichomonas vaginalis phosphofructokinase, putative 0.0223 0.0907 0.2573
Schistosoma mansoni hypothetical protein 0.0266 0.1098 0.2545
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.023 0.0938 0.3205
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.0079 0.0181
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0064 0.0668
Brugia malayi EGF-like domain containing protein 0.0048 0.0129 0.0439
Loa Loa (eye worm) ATP-dependent DNA helicase 0.004 0.009 0.0305
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0182 0.5783
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0034 0.0343
Schistosoma mansoni lozenge 0.0056 0.0162 0.0375
Chlamydia trachomatis neutral amino acid transporter 0.011 0.0405 0.2654
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0091 0.009
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.1071 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Echinococcus granulosus bloom syndrome protein 0.0067 0.0211 0.021
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0098 0.0348 0.0347
Echinococcus multilocularis receptor type guanylyl cyclase 0.0037 0.0079 0.0078
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0451 0.4109
Loa Loa (eye worm) CUTiclin-Like family member 0.0042 0.0101 0.0341
Onchocerca volvulus 0.0086 0.0298 0.088
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0155 0.0605 0.0604
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.0079 0.0267
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0099 0.0098
Echinococcus granulosus glutamate receptor 2 0.0068 0.0218 0.0217
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.0079 0.0078
Brugia malayi Receptor family ligand binding region containing protein 0.0037 0.0079 0.0266
Entamoeba histolytica phosphofructokinase, putative 0.0223 0.0907 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.006 0.0182 0.5783
Brugia malayi hypothetical protein 0.0119 0.0444 0.1513
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0086 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0182 0.036
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0091 0.0083
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0064 0.0336
Schistosoma mansoni rab6-interacting 0.002 0.0004 0.0008
Echinococcus multilocularis sodium:dicarboxylate symporter 0.011 0.0405 0.0404
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0078 0.0262 0.0894
Schistosoma mansoni axis inhibition protein axin 0.004 0.0091 0.0209
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.0079 0.0267
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0106 0.0386 0.0385
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0091 0.0309
Brugia malayi Pre-SET motif family protein 0.0677 0.2927 1
Brugia malayi glutathione reductase 0.0048 0.0125 0.0426
Echinococcus granulosus GPCR family 3 C terminal 0.0041 0.0097 0.0096
Echinococcus granulosus Excitatory amino acid transporter 0.0249 0.1023 0.1022
Brugia malayi 6-phosphofructokinase 0.0223 0.0907 0.3098
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0077 0.0256 0.0592
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.0012
Echinococcus granulosus beta-adrenergic receptor kinase 0.004 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0091 0.0209
Echinococcus multilocularis axis inhibition protein axin 0.004 0.0091 0.009
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Echinococcus multilocularis regulator of G protein signaling 0.004 0.0091 0.009
Plasmodium falciparum glutathione reductase 0.0048 0.0125 0.3941
Schistosoma mansoni DNA helicase recq1 0.004 0.009 0.0207
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.004 0.0091 0.009
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.004 0.0091 0.0209
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.0079 0.0267
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.0079 0.0181
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0041 0.0097 0.0278
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0223 0.0907 1
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0079 0.0267
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0042 0.0101 0.0341
Schistosoma mansoni metabotropic glutamate receptor 0.0226 0.092 0.2132
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.0211 0.045
Trichomonas vaginalis DNA helicase recq, putative 0.0045 0.0115 0.0156
Echinococcus multilocularis pikachurin 0.0048 0.0129 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0138 0.1491
Entamoeba histolytica exodeoxyribonuclease III, putative 0.006 0.0178 0.1967
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.006 0.0178 0.165
Schistosoma mansoni thyroid hormone receptor 0.0303 0.1264 0.2928
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.1071 1
Brugia malayi Excitatory amino acid transporter 0.0249 0.1023 0.3493
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0182 0.036
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0077 0.0256 0.2824
Echinococcus granulosus voltage dependent calcium channel subunit 0.103 0.4501 0.45
Echinococcus granulosus metabotropic glutamate receptor 5 0.0326 0.1365 0.1364
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0101 0.111
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0249 0.1023 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0025 0.0023 0.0673
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0259 0.1067 0.1066
Brugia malayi Intermediate filament tail domain containing protein 0.0086 0.0298 0.1016
Schistosoma mansoni hypothetical protein 0.0175 0.0695 0.1609
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0004 0.0003
Entamoeba histolytica phosphofructokinase, putative 0.0223 0.0907 1
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0129 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0091 0.0083
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.011 0.0405 0.0937
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0091 0.0083
Entamoeba histolytica hypothetical protein 0.0039 0.0086 0.095
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0439 0.1017
Schistosoma mansoni hypothetical protein 0.002 0.0004 0.0008
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0026 0.0087
Brugia malayi hypothetical protein 0.004 0.0091 0.0309
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0023 0.0187
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.0079 0.0223
Schistosoma mansoni loxhd1 0.002 0.0004 0.0008
Echinococcus multilocularis glutamate receptor 2 0.0094 0.0333 0.0332
Chlamydia trachomatis glutamate symporter 0.0249 0.1023 1
Echinococcus multilocularis excitatory amino acid transporter 3 0.0249 0.1023 0.1022
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0167 0.057
Echinococcus multilocularis regulator of G protein signaling 7 0.004 0.0091 0.009
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0023 0.0221
Echinococcus multilocularis musashi 0.0086 0.0298 0.0297
Brugia malayi Receptor family ligand binding region containing protein 0.0078 0.0262 0.0894
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0223 0.0907 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.0079 0.0078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.0079 0.0078
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0112 0.0111
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0026 0.0028 0.0028
Echinococcus multilocularis expressed protein 0.0777 0.3374 0.3373
Schistosoma mansoni cell polarity protein 0.0048 0.0129 0.0298
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.0079 0.0181
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0167 0.0167
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0089 0.0311 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0266
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0039 0.0086 0.0198
Echinococcus granulosus Regulator of G protein signaling 20 0.004 0.0091 0.009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.1071 1
Loa Loa (eye worm) glutathione reductase 0.0048 0.0125 0.0426
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0397 0.3597
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0086 0.0198
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.006 0.0182 0.0294
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.0348 0.0347
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0259 0.1067 0.3643
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0122
Echinococcus granulosus ATP dependent DNA helicase Q5 0.004 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0042 0.0101 0.0341
Echinococcus granulosus excitatory amino acid transporter 3 0.0249 0.1023 0.1022
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0064 0.0703
Echinococcus multilocularis glutamate receptor 2 0.0068 0.0218 0.0217
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.006 0.0178 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.0079 0.0267
Toxoplasma gondii phosphofructokinase PFKII 0.006 0.0182 0.1672
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0004 0.0124
Leishmania major extracellular receptor, putative 0.0037 0.0079 0.0528
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0397 0.3597
Loa Loa (eye worm) PXA domain-containing protein 0.004 0.0091 0.0309
Echinococcus multilocularis expressed protein 0.0035 0.0067 0.0067
Brugia malayi hypothetical protein 0.002 0.0004 0.0012
Echinococcus multilocularis neutral amino acid transporter A 0.0249 0.1023 0.1022
Trichomonas vaginalis ap endonuclease, putative 0.006 0.0178 0.035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.0348 0.0347
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.004 0.009 0.0305
Schistosoma mansoni rab6-interacting 0.002 0.0004 0.0008
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.006 0.0178 0.148
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.006 0.0178 0.1523
Schistosoma mansoni hypothetical protein 0.0423 0.1799 0.4169
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0249 0.1023 0.1022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.004 0.009 0.0811
Treponema pallidum glutamate/aspartate transporter 0.011 0.0405 0.0661
Echinococcus granulosus nmda type glutamate receptor 0.0037 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0309
Schistosoma mansoni ap endonuclease 0.006 0.0178 0.0412
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0034 0.099
Loa Loa (eye worm) hypothetical protein 0.0456 0.1944 0.6643
Echinococcus multilocularis tyrosine kinase 0.0037 0.0079 0.0078
Onchocerca volvulus 0.0037 0.0079 0.0223
Brugia malayi hypothetical protein 0.0039 0.0086 0.0292
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.0079 0.0267
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0077 0.0256 0.0873
Entamoeba histolytica phosphofructokinase, putative 0.0223 0.0907 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0077 0.0256 0.2222
Schistosoma mansoni serine/threonine protein kinase 0.004 0.0091 0.0209
Brugia malayi steroid hormone receptor 0.0037 0.0079 0.0267
Treponema pallidum glutamate transporter 0.011 0.0405 0.0661
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0087 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0098 0.0348 0.1187
Schistosoma mansoni blooms syndrome DNA helicase 0.0047 0.0121 0.0279
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.006 0.0178 0.0178
Schistosoma mansoni rotamase 0.0035 0.0067 0.0154
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0129 0.0439
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) glutamate receptor 0.0267 0.1104 0.377
Entamoeba histolytica recQ family helicase, putative 0.0045 0.0115 0.1268
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0138 0.047
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.0079 0.0267
Schistosoma mansoni polycystin 1-related 0.002 0.0004 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0079 0.0267
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0079 0.0078
Onchocerca volvulus 0.0042 0.0101 0.0289
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.004 0.0091 0.0309
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0125 0.1349
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0115 0.1235
Schistosoma mansoni glutamate receptor kainate 0.0118 0.0439 0.1017
Onchocerca volvulus 0.077 0.3342 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0004 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.0079 0.0267
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.0079 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0151 0.0348
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0045 0.0115 0.0924
Echinococcus granulosus RUN 0.002 0.0004 0.0003
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.0101 0.0113
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0086 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0091 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.0079 0.0267
Loa Loa (eye worm) RGS-3 protein 0.004 0.0091 0.0309
Schistosoma mansoni tyrosine kinase 0.0037 0.0079 0.0181
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0098 0.0348 0.3228
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.006 0.0182 1
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0042 0.0101 0.2894
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.0079 0.0267
Loa Loa (eye worm) hypothetical protein 0.0048 0.0129 0.0439
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.0079 0.0267
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Schistosoma mansoni hypothetical protein 0.0026 0.0028 0.0064
Echinococcus multilocularis RUN 0.002 0.0004 0.0003
Loa Loa (eye worm) RGC/RGC protein kinase 0.0037 0.0079 0.0266
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0041 0.0096 0.0868
Mycobacterium ulcerans 6-phosphofructokinase 0.0223 0.0907 0.8443
Loa Loa (eye worm) 6-phosphofructokinase 0.0223 0.0907 0.3098
Loa Loa (eye worm) intermediate filament protein 0.0086 0.0298 0.1016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0099 0.0098
Brugia malayi metabotropic glutamate receptor type 2 0.0137 0.0524 0.1788
Schistosoma mansoni cpg binding protein 0.003 0.0046 0.0104
Plasmodium falciparum cysteine repeat modular protein 1 0.0025 0.0023 0.0622
Schistosoma mansoni hypothetical protein 0.0041 0.0097 0.0223
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0129 0.0298
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.0267
Echinococcus granulosus glutamate receptor 2 0.0094 0.0333 0.0332
Schistosoma mansoni protein kinase 0.0037 0.0079 0.0181
Onchocerca volvulus 0.0098 0.0348 0.103
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0167 0.0386
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.0079 0.0267
Loa Loa (eye worm) hypothetical protein 0.004 0.0091 0.0309
Echinococcus multilocularis tumor protein p63 0.0364 0.1536 0.1535
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0024 0.0018 0.0041
Echinococcus multilocularis GPCR, family 3, C terminal 0.0041 0.0097 0.0096
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0326 0.1365 0.1364
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0004 0.0003
Schistosoma mansoni DNA helicase recq5 0.004 0.009 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0348 0.0805
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0094 0.0333 0.0332
Echinococcus granulosus lamin 0.0086 0.0298 0.0297
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.0079 0.0078
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0125 0.3601
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.0079 0.0078
Loa Loa (eye worm) hypothetical protein 0.0089 0.0311 0.1062
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.0079 0.0078
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0129 0.0439
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0042 0.0101 0.0341
Brugia malayi exodeoxyribonuclease III family protein 0.006 0.0178 0.0607
Schistosoma mansoni hypothetical protein 0.0175 0.0695 0.1609
Plasmodium vivax glutathione reductase, putative 0.0048 0.0125 0.3601
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0077 0.0256 0.0255
Onchocerca volvulus Poor gastrulation protein homolog 0.0041 0.0097 0.0278
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0061 0.0186 0.5921
Onchocerca volvulus 0.005 0.0138 0.0401
Echinococcus multilocularis nmda type glutamate receptor 0.0037 0.0079 0.0078
Trichomonas vaginalis rotamase, putative 0.0035 0.0067 0.0011
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.004 0.009 0.0089
Brugia malayi von Willebrand factor type A domain containing protein 0.0042 0.0101 0.0341
Brugia malayi Protein kinase domain containing protein 0.0025 0.0023 0.0077
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.0079 0.0078
Loa Loa (eye worm) runx1 0.0056 0.0162 0.0552
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.006 0.0178 0.0607
Onchocerca volvulus 0.0042 0.0101 0.0289
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0348 0.0805
Loa Loa (eye worm) hypothetical protein 0.004 0.0092 0.0312
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0129 0.0298
Loa Loa (eye worm) hypothetical protein 0.0085 0.0291 0.0992
Plasmodium vivax 6-phosphofructokinase, putative 0.006 0.0182 0.5226
Echinococcus multilocularis Regulator of G protein signaling 20 0.004 0.0091 0.009
Brugia malayi intermediate filament protein 0.0086 0.0298 0.1016
Trypanosoma cruzi extracellular receptor, putative 0.0037 0.0079 0.0833
Loa Loa (eye worm) hypothetical protein 0.004 0.009 0.0305
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0046 0.012 0.0406
Toxoplasma gondii exonuclease III APE 0.006 0.0178 0.1639
Brugia malayi Regulator of G protein signaling domain containing protein 0.004 0.0091 0.0309
Loa Loa (eye worm) hypothetical protein 0.0042 0.0101 0.0341
Schistosoma mansoni regulator of G protein signaling 0.004 0.0091 0.0209
Echinococcus granulosus excitatory amino acid transporter 2 0.0249 0.1023 0.1022
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0034 0.0982
Onchocerca volvulus 0.0025 0.0023 0.0057
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.004 0.0091 0.009
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.006 0.0178 0.1523
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0067 0.0227
Onchocerca volvulus 0.0042 0.0101 0.0289
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0155 0.0605 0.0604
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0259 0.1067 0.2471
Echinococcus multilocularis thyroid hormone receptor alpha 0.0303 0.1264 0.1263
Brugia malayi hypothetical protein 0.0126 0.0475 0.1619
Echinococcus granulosus 6 phosphofructokinase 0.0223 0.0907 0.0906
Onchocerca volvulus 0.0037 0.0079 0.0223
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0289 0.12 0.278
Echinococcus granulosus geminin 0.0175 0.0695 0.0694
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0199 0.1889
Schistosoma mansoni lipoxygenase 0.002 0.0004 0.0008
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0042 0.0101 0.314
Entamoeba histolytica elongation factor-2 kinase, putative 0.0042 0.0101 0.111
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.1016 0.1015
Loa Loa (eye worm) hypothetical protein 0.0053 0.0151 0.0513
Echinococcus multilocularis beta adrenergic receptor kinase 0.004 0.0091 0.009
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0167 0.057
Schistosoma mansoni lipoxygenase 0.0057 0.0168 0.0387
Leishmania major cathepsin L-like protease 0.0064 0.0199 0.1679
Trichomonas vaginalis phosphofructokinase, putative 0.006 0.0182 0.036
Brugia malayi ecdysteroid receptor 0.0037 0.0079 0.0267
Schistosoma mansoni slit 0.0048 0.0129 0.0298
Echinococcus granulosus axis inhibition protein axin 0.004 0.0091 0.009
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.1071 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.37 nM In vitro binding affinity using [3H]-prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell ChEMBL. 10780916
Ki (binding) = 0.37 nM In vitro binding affinity using [3H]-prazosin as radioligand against alpha-1D adrenergic receptor expressed in LTK cell ChEMBL. 10780916
Ki (binding) = 0.53 nM In vitro binding affinity using [3H]-prazosin as radioligand against alpha-1A adrenergic receptor ChEMBL. 10780916
Ki (binding) = 0.53 nM In vitro binding affinity using [3H]-prazosin as radioligand against alpha-1A adrenergic receptor ChEMBL. 10780916
Ki (binding) = 3.33 nM In vitro binding affinity using [3H]-prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cell ChEMBL. 10780916
Ki (binding) = 3.33 nM In vitro binding affinity using [3H]-prazosin as radioligand against alpha-1B adrenergic receptor expressed in LTK cell ChEMBL. 10780916
Selectivity ratio (binding) = 6.28 Ratio between Ki(alpha1b)/Ki(alpha1A) ChEMBL. 10780916

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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