Detailed information for compound 58955

Basic information

Technical information
  • TDR Targets ID: 58955
  • Name: 2-chloro-5-[2-[(2-hydroxy-3-naphthalen-1-ylox ypropyl)amino]ethylamino]benzenesulfonamide
  • MW: 449.951 | Formula: C21H24ClN3O4S
  • H donors: 4 H acceptors: 3 LogP: 2.97 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(COc1cccc2c1cccc2)CNCCNc1ccc(c(c1)S(=O)(=O)N)Cl
  • InChi: 1S/C21H24ClN3O4S/c22-19-9-8-16(12-21(19)30(23,27)28)25-11-10-24-13-17(26)14-29-20-7-3-5-15-4-1-2-6-18(15)20/h1-9,12,17,24-26H,10-11,13-14H2,(H2,23,27,28)
  • InChiKey: NUPOPPYKLMMBNH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-5-[2-[[2-hydroxy-3-(1-naphthyloxy)propyl]amino]ethylamino]benzenesulfonamide
  • 2-chloro-5-[2-[[2-hydroxy-3-(1-naphthalenyloxy)propyl]amino]ethylamino]benzenesulfonamide
  • 2-chloro-5-[2-[(2-hydroxy-3-naphthalen-1-yloxy-propyl)amino]ethylamino]benzenesulfonamide
  • 2-chloro-5-[2-[[2-hydroxy-3-(1-naphthoxy)propyl]amino]ethylamino]benzenesulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adrenoceptor beta 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0072 0.0355
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0197 0.0194
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0024 0.0024
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0222 0.4193
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0288 0.1122
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0288 0.1479
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0025 0.0114
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0038 0.0127
Echinococcus granulosus mothers against decapentaplegic 6 0.0007 0.0017 0.0014
Entamoeba histolytica hypothetical protein, conserved 0.0355 0.2547 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.024
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0137 0.0134
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0035 0.0032
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0126
Mycobacterium tuberculosis Conserved protein 0.0355 0.2547 0.7531
Trypanosoma cruzi diacylglycerol kinase, putative 0.0014 0.0064 0.1224
Treponema pallidum ATP-dependent DNA helicase 0.0005 0 0.5
Leishmania major diacylglycerol kinase-like protein 0.0014 0.0064 0.018
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0008 0.0025 0.0022
Schistosoma mansoni DNA helicase recq1 0.001 0.0035 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.0699
Mycobacterium ulcerans glutaminase 0.0271 0.1932 0.7521
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0183 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0012 0.0051 0.0242
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0072 0.101
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0035 0.0166
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0072 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0032 0.0114
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0495 0.1308
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0038 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1919 0.9933
Schistosoma mansoni cpg binding protein 0.0029 0.0176 0.0176
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0038 0.0035
Leishmania major hypothetical protein, conserved 0.0014 0.0064 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Brugia malayi Inositol-1 0.0037 0.0234 0.1196
Echinococcus granulosus sphingosine kinase 1 0.0355 0.2547 0.2545
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0064 0.0252
Loa Loa (eye worm) hypothetical protein 0.0007 0.0011 0.0031
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0495 0.1308
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0234 0.5
Loa Loa (eye worm) hypothetical protein 0.012 0.0837 0.3278
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1315 0.6803
Echinococcus multilocularis mothers against decapentaplegic 6 0.0007 0.0017 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Echinococcus multilocularis Diacylglycerol kinase theta 0.0014 0.0064 0.0061
Leishmania major diacylglycerol kinase, putative 0.0014 0.0064 0.018
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0084 0.0318
Loa Loa (eye worm) RecQ helicase 0.0024 0.0137 0.0527
Schistosoma mansoni glutaminase 0.0271 0.1932 0.1932
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0038 0.0038
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0007 0.0011 0.0008
Brugia malayi beta-lactamase 0.0073 0.0495 0.2552
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0183
Trichomonas vaginalis helicase, putative 0.0007 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0495 0.0495
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0035 0.0032
Loa Loa (eye worm) MH2 domain-containing protein 0.0007 0.0017 0.0056
Loa Loa (eye worm) nuclear factor I 0.0009 0.003 0.0106
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.0035
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0234 0.0683
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0008 0.0025 0.0022
Schistosoma mansoni microtubule-associated protein tau 0.1381 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0064 0.0312
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0222 0.113
Schistosoma mansoni diacylglycerol kinase theta 0.0014 0.0064 0.0064
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0197 0.1005
Echinococcus multilocularis geminin 0.0176 0.1246 0.1244
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1935
Schistosoma mansoni hypothetical protein 0.0036 0.0224 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0072 0.0355
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0014 0.0064 0.1224
Trichomonas vaginalis bmru protein, putative 0.0014 0.0064 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0183
Brugia malayi Diacylglycerol kinase protein 2 0.0014 0.0064 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0084 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Schistosoma mansoni hypothetical protein 0.0014 0.0064 0.0064
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0038 0.0139
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Echinococcus granulosus ceramide kinase 0.0014 0.0064 0.0061
Brugia malayi steroid hormone receptor 0.001 0.0038 0.0183
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0495 0.1308
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0014 0.0064 0.1295
Brugia malayi MH2 domain containing protein 0.0017 0.0084 0.0419
Onchocerca volvulus 0.0073 0.0495 0.2886
Echinococcus multilocularis sphingosine kinase 1 0.0355 0.2547 0.2545
Schistosoma mansoni inositol monophosphatase 0.0037 0.0234 0.0234
Brugia malayi hypothetical protein 0.0036 0.0224 0.1144
Brugia malayi Ceramide kinase 0.0014 0.0064 0.0317
Echinococcus granulosus bloom syndrome protein 0.0024 0.0137 0.0134
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0014 0.0064 0.1224
Schistosoma mansoni Smad4 0.0007 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0014 0.0064 0.0061
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0024 0.0021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0038 0.0035
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0014 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0038 0.0038
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0035 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.0699
Onchocerca volvulus 0.003 0.0183 0.1001
Echinococcus granulosus mothers against decapentaplegic 2 0.0007 0.0017 0.0014
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0038 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0156 0.0787
Schistosoma mansoni hypothetical protein 0.0069 0.0468 0.0468
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0008 0.0025 0.0098
Mycobacterium ulcerans hypothetical protein 0.0355 0.2547 1
Brugia malayi Eye-specific diacylglycerol kinase 0.0014 0.0064 0.0317
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Schistosoma mansoni DNA helicase recq5 0.001 0.0035 0.0035
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0495 0.1935
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0014 0.0064 0.0312
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0056 0.0221
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0183
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0197 0.1005
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0495 1
Trypanosoma brucei diacylglycerol kinase, putative 0.0014 0.0064 0.0833
Echinococcus multilocularis serine protein kinase ATM 0.0008 0.0025 0.0022
Brugia malayi Pre-SET motif family protein 0.003 0.0183 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0495 0.0495
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0183 0.3696
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0005 0.0002 0.0002
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0038 0.0038
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0038 0.0139
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0222 0.4441
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0288 0.5788
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0205 0.4141
Plasmodium falciparum diacylglycerol kinase, putative 0.0014 0.0064 0.3588
Loa Loa (eye worm) MH1 domain-containing protein 0.0007 0.0017 0.0056
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0038
Echinococcus granulosus dnaJ subfamily B 0.0417 0.2992 0.2989
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0234 0.1192
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0495 1
Loa Loa (eye worm) inositol-1 0.0037 0.0234 0.0907
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.0035
Loa Loa (eye worm) glutaminase 2 0.0271 0.1932 0.7581
Echinococcus multilocularis cpg binding protein 0.0031 0.0188 0.0185
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0098 0.1562
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0183
Entamoeba histolytica hypothetical protein 0.0036 0.0224 0.0878
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0222 0.3779
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0183
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1919 0.9933
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0495 1
Brugia malayi nuclear receptor NHR-88 0.001 0.0038 0.0183
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0224 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0174 0.0884
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.0035
Mycobacterium leprae Probable lipase LipE 0.0073 0.0495 1
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0064 0.0833
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0495 0.1308
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.1919 0.753
Schistosoma mansoni fkbp-rapamycin associated protein 0.0008 0.0025 0.0025
Brugia malayi MH2 domain containing protein 0.0017 0.0084 0.0419
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0495 0.2549
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0495 1
Brugia malayi beta-lactamase family protein 0.0073 0.0495 0.2552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0158 0.0797
Brugia malayi hypothetical protein 0.0014 0.0064 0.0317
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0288 0.5287
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Trichomonas vaginalis sphingosine kinase, putative 0.0014 0.0064 0.0312
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1935
Schistosoma mansoni hypothetical protein 0.0176 0.1246 0.1246
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0035 0.0166
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.004
Trypanosoma cruzi Sphingosine kinase 0.0014 0.0064 0.1224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.07
Trypanosoma cruzi diacylglycerol kinase, putative 0.0014 0.0064 0.1224
Onchocerca volvulus 0.001 0.0038 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0183
Schistosoma mansoni inositol monophosphatase 0.0037 0.0234 0.0234
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0014 0.0064 0.024
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Echinococcus granulosus Diacylglycerol kinase theta 0.0014 0.0064 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.0035
Trichomonas vaginalis diacylglycerol kinase, putative 0.0014 0.0064 0.0312
Echinococcus granulosus serine protein kinase ATM 0.0008 0.0025 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0495 0.2549
Schistosoma mansoni smad 0.0007 0.0017 0.0017
Brugia malayi diacylglycerol kinase 0.0014 0.0064 0.0317
Echinococcus multilocularis Smad4 0.0017 0.0084 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0037 0.0034
Echinococcus granulosus active breakpoint cluster region 0.0112 0.0777 0.0774
Mycobacterium tuberculosis Conserved protein 0.0073 0.0495 0.1308
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0081 0.0387
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0495 0.2552
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0084 0.0318
Schistosoma mansoni smad 0.0017 0.0084 0.0084
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0014 0.0064 0.0061
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0288 0.56
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0137 0.0695
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0038 0.0035
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0072 0.101
Leishmania major sphingosine kinase A, B, putative 0.0014 0.0064 0.018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0038 0.0038
Brugia malayi beta-lactamase family protein 0.0073 0.0495 0.2552
Schistosoma mansoni Smad4 0.0007 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.024
Echinococcus multilocularis GPCR, family 2 0.0032 0.0197 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0139
Mycobacterium tuberculosis Conserved protein 0.0073 0.0495 0.1308
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0014 0.0064 0.1295
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0035 0.0709
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.2992 0.2989
Brugia malayi FAT domain containing protein 0.0007 0.0011 0.0041
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0084 0.0084
Loa Loa (eye worm) beta-lactamase 0.0073 0.0495 0.1935
Loa Loa (eye worm) hypothetical protein 0.0006 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0101 0.0701 0.2745
Schistosoma mansoni cpg binding protein 0.0031 0.0188 0.0188
Plasmodium falciparum diacylglycerol kinase, putative 0.0014 0.0064 0.3588
Mycobacterium ulcerans lipase LipD 0.0073 0.0495 0.1737
Mycobacterium ulcerans beta-lactamase 0.0073 0.0495 0.1737
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Loa Loa (eye worm) hypothetical protein 0.0069 0.0468 0.1827
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0056 0.1063
Loa Loa (eye worm) MH2 domain-containing protein 0.0243 0.173 0.679
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0064 0.0252
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0084 0.0081
Brugia malayi CXXC zinc finger family protein 0.0029 0.0176 0.0897
Brugia malayi glutaminase DH11.1 0.0271 0.1932 1
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0197
Echinococcus multilocularis mothers against decapentaplegic 2 0.0007 0.0017 0.0014
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0024 0.0021
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0288 0.0285
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0038 0.0035
Schistosoma mansoni Smad4 0.0017 0.0084 0.0084
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0422 0.0422
Brugia malayi MH1 domain containing protein 0.0009 0.003 0.014
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0072 0.0069
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0084 0.0081
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0183 0.018
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0495 0.1308
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0038 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0495 0.1308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0222 0.113
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0183
Trichomonas vaginalis diacylglycerol kinase, putative 0.0014 0.0064 0.0312
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0288 0.5287
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0035 0.0126
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0234 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0116 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0197 0.0194
Onchocerca volvulus Glucosylceramidase homolog 0.0176 0.1246 0.7421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0158 0.0797
Mycobacterium tuberculosis Conserved protein 0.0073 0.0495 0.1308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0288 0.1475
Brugia malayi MH1 domain containing protein 0.0017 0.0084 0.0419
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.0035
Toxoplasma gondii FATC domain-containing protein 0.0008 0.0025 0.0503
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0117 0.196
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0139
Schistosoma mansoni sphingoid long chain base kinase 0.0355 0.2547 0.2547
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.0035
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0014 0.0064 0.0312
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0014 0.0064 0.0064
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0495 0.1308
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0183 0.0183
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0024 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0495 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0374 0.7555
Echinococcus granulosus GPCR family 2 0.0032 0.0197 0.0194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0197 0.0762
Trichomonas vaginalis esterase, putative 0.0073 0.0495 0.2549
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0495 0.0492
Echinococcus granulosus FTZ F1 alpha 0.001 0.0038 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0176 0.068
Brugia malayi Pre-SET motif family protein 0.0207 0.1467 0.7589
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1674 0.8661
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0137 0.069
Loa Loa (eye worm) histone methyltransferase 0.001 0.0037 0.0134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.0035
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0008 0.0025 0.0025
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0183 0.0183
Entamoeba histolytica protein kinase rad3, putative 0.0008 0.0025 0.0098
Schistosoma mansoni hypothetical protein 0.0007 0.0011 0.0011
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0037 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0222 0.113
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0234 0.4718
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0181 0.092
Brugia malayi diacylglycerol kinase 0.0014 0.0064 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0038 0.0183
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0007 0.0011 0.0008
Entamoeba histolytica hypothetical protein 0.0036 0.0224 0.0878
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1919 0.9933
Onchocerca volvulus 0.0235 0.1674 1
Onchocerca volvulus 0.0029 0.0176 0.0959
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0072 0.1393
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0197 0.0194
Brugia malayi MH2 domain containing protein 0.0243 0.173 0.8956
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.0035
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0038 0.0035
Echinococcus granulosus Smad4 0.0017 0.0084 0.0081
Schistosoma mansoni sphingosine kinase A B 0.0355 0.2547 0.2547
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0183
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1935
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0064 0.1224
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0011 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0468 0.241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0072 0.0355
Plasmodium vivax SET domain protein, putative 0.003 0.0183 0.2758
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0008 0.0025 0.0427
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0079 0.1604
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0288 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0158 0.0797
Schistosoma mansoni smad1 5 8 and 0.0017 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0222 0.113
Trypanosoma brucei Sphingosine kinase 0.0014 0.0064 0.0833
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0072 0.0072
Schistosoma mansoni nuclear hormone receptor 0.001 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Echinococcus granulosus smad 0.0017 0.0084 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0025 0.0109
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0288 0.5788
Onchocerca volvulus 0.0073 0.0495 0.2886
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0038
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0495 0.1737
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0038 0.0183
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.0035
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0014 0.0064 0.0312
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.004
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0064 0.0252
Loa Loa (eye worm) ceramide kinase 0.0014 0.0064 0.024
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0101 0.0101
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0056 0.0665
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0008 0.0025 0.0427
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0024 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Schistosoma mansoni smad1 5 8 and 0.0017 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0495 0.2549
Loa Loa (eye worm) transcription factor SMAD2 0.0243 0.173 0.679
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0139
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0014 0.0064 0.0833
Onchocerca volvulus 0.0073 0.0495 0.2886
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0234 0.4675
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0183
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1935
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0288 0.56
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.07
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0288 0.1475
Entamoeba histolytica hypothetical protein 0.0008 0.0025 0.0098
Brugia malayi MH1 domain containing protein 0.0017 0.0084 0.0419
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0197
Leishmania major hypothetical protein, conserved 0.0014 0.0064 0.018
Brugia malayi MH1 domain containing protein 0.0009 0.003 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Brugia malayi MH2 domain containing protein 0.0007 0.0017 0.0074
Schistosoma mansoni cpg binding protein 0.0031 0.0188 0.0188
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.07
Trypanosoma cruzi Sphingosine kinase 0.0014 0.0064 0.1224
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.1246 0.6445
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1919 0.9933
Echinococcus granulosus cpg binding protein 0.0031 0.0188 0.0185
Onchocerca volvulus Ceramide kinase 1 homolog 0.0014 0.0064 0.0283
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0495 0.1737
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0495 0.2549
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0064 0.0252
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0234 0.4042
Echinococcus granulosus geminin 0.0176 0.1246 0.1244
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1919 0.9933
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0035 0.0032
Loa Loa (eye worm) Smad1 0.0017 0.0084 0.0318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0072 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0288 0.1475
Brugia malayi mothers against decapentaplegic homolog 3 0.0007 0.0017 0.0074
Loa Loa (eye worm) hypothetical protein 0.0008 0.0025 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0038 0.0183
Schistosoma mansoni diacylglycerol kinase theta 0.0014 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0009 0.0032 0.0145
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0072 0.1393
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1935
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0495 0.0492
Trichomonas vaginalis sphingosine kinase, putative 0.0014 0.0064 0.0312
Loa Loa (eye worm) hypothetical protein 0.003 0.0183 0.0708
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0234 0.4438
Schistosoma mansoni hypothetical protein 0.0176 0.1246 0.1246
Schistosoma mansoni hypothetical protein 0.0032 0.0197 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0222 0.113
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0495 0.2549
Loa Loa (eye worm) hypothetical protein 0.0009 0.003 0.0106
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0038 0.0127
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0234 0.4675
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0234 0.1192
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0205 0.0428
Schistosoma mansoni hypothetical protein 0.0417 0.2992 0.2992
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0156 0.0787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0205 0.1043
Brugia malayi Smad1 0.0017 0.0084 0.0419
Entamoeba histolytica hypothetical protein 0.0036 0.0224 0.0878
Loa Loa (eye worm) hypothetical protein 0.0014 0.0064 0.024
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1467 0.5753
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0008 0.0025 0.0114
Toxoplasma gondii ABC1 family protein 0.0073 0.0495 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.004
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0014 0.0064 0.1224
Echinococcus granulosus Diacylglycerol kinase zeta 0.0014 0.0064 0.0061
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0035 0.0709
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0224 0.0221
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0183 0.018
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0012 0.004
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0467 0.3361 1
Schistosoma mansoni coup transcription factor 0.001 0.0038 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0072 0.0355
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.004
Brugia malayi ecdysteroid receptor 0.001 0.0038 0.0183
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0288 0.0285
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0012 0.004
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0701 0.3621
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0084 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0025 0.0109
Loa Loa (eye worm) hypothetical protein 0.0355 0.2547 1
Echinococcus multilocularis ceramide kinase 0.0014 0.0064 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.0699
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.1315 0.6803
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0036 0.0173
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0701 0.2745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0241 0.1229
Loa Loa (eye worm) hypothetical protein 0.0007 0.0017 0.0056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0038 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0038 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0008 0.0025 0.0109
Loa Loa (eye worm) glutaminase 0.0271 0.1932 0.7581
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0234 0.1192
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0288 0.0288
Brugia malayi nuclear hormone receptor 0.001 0.0038 0.0183
Toxoplasma gondii diacylglycerol kinase, putative 0.0014 0.0064 0.1295
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0072 0.037
Loa Loa (eye worm) hypothetical protein 0.0009 0.003 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0139
Echinococcus multilocularis smad 0.0017 0.0084 0.0081
Echinococcus multilocularis microtubule associated protein 2 0.1381 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0171 0.0168
Loa Loa (eye worm) diacylglycerol kinase 2 0.0014 0.0064 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0072 0.0355
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0234 0.0231
Schistosoma mansoni smad1 5 8 and 0.0017 0.0084 0.0084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0701 0.3621
Giardia lamblia GTOR 0.0045 0.0288 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0038 0.0183
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0014 0.0064 0.0061
Echinococcus multilocularis active breakpoint cluster region 0.0112 0.0777 0.0774
Loa Loa (eye worm) hypothetical protein 0.0073 0.0495 0.1935
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0012 0.004
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0224 0.0221
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.1919 0.9933
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0072 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0183 0.0183
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0234 0.0917
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0139 0.07
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0288 0.1132
Leishmania major hypothetical protein, conserved 0.0073 0.0495 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0197 0.0194
Mycobacterium ulcerans hypothetical protein 0.0073 0.0495 0.1737
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.1919 0.9933
Loa Loa (eye worm) hypothetical protein 0.0032 0.0197 0.0762
Entamoeba histolytica hypothetical protein 0.0036 0.0224 0.0878
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0072 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0139
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0056 0.0271
Trichomonas vaginalis glutaminase, putative 0.0271 0.1932 1
Onchocerca volvulus 0.0014 0.0064 0.0283
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0137 0.069
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0183 0.0183
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0009 0.0032 0.0645
Trichomonas vaginalis bmru protein, putative 0.0014 0.0064 0.0312

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1.6 m equiv kg-1 Saluretic activity was evaluated for K+ by flame photometry at 8 mg/kg perorally ChEMBL. 8093626
Activity (functional) = 2 m equiv kg-1 Saluretic activity was evaluated for K+ by flame photometry at 15 mg/kg perorally ChEMBL. 8093626
Activity (functional) = 2.6 m equiv kg-1 Saluretic activity was evaluated for K+ by flame photometry at 30 mg/kg perorally ChEMBL. 8093626
Activity (functional) = 2.8 m equiv kg-1 Saluretic activity was evaluated for Na+ by flame photometry at 8 mg/kg perorally ChEMBL. 8093626
Activity (functional) = 3.1 m equiv kg-1 Saluretic activity was evaluated for Na+ by flame photometry at 15 mg/kg perorally ChEMBL. 8093626
Activity (functional) = 3.2 m equiv kg-1 Saluretic activity was evaluated for Na+ by flame photometry at 30 mg/kg perorally ChEMBL. 8093626
ED50 (functional) 0 mg kg-1 beta-adrenoceptor blocking activity of the intravenously administered compound was evaluated by inhibition of isiprenaline-induced tachycardia in rats; NA indiactes not active ChEMBL. 8093626
ED50 (functional) = 40.69 mg kg-1 beta-adrenoceptor blocking activity of the perorally administered compound was evaluated by inhibition of isiprenaline-induced tachycardia in rats ChEMBL. 8093626
ED50 (functional) = 40.69 mg kg-1 beta-adrenoceptor blocking activity of the perorally administered compound was evaluated by inhibition of isiprenaline-induced tachycardia in rats ChEMBL. 8093626
Ki (binding) = 15 nM Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes. ChEMBL. 8093626
Ki (binding) = 15 nM Inhibition of [3H]-Dihydroalprenolol binding to beta 1 adrenoceptor from turkey erythrocyte membranes. ChEMBL. 8093626
Ratio (functional) = 1.2 Ratio of saluretic activity for Na+ over saluretic activity of K+ in rats after peroral administration of 30 mg/kg of compound ChEMBL. 8093626
Ratio (functional) = 1.5 Ratio of saluretic activity for Na+ over saluretic activity of K+ in rats after peroral administration of 15 mg/kg of compound ChEMBL. 8093626
Ratio (functional) = 1.7 Ratio of saluretic activity for Na+ over saluretic activity of K+ in rats after peroral administration of 8 mg/kg of compound ChEMBL. 8093626
Urinary output (functional) = 2.4 ml Diuretic activity given as urinary output of 8 mg/kg perorally administered compound in rats ChEMBL. 8093626
Urinary output (functional) = 3.2 ml Diuretic activity given as urinary output of 15 mg/kg perorally administered compound in rats ChEMBL. 8093626
Urinary output (functional) = 3.5 ml Diuretic activity given as urinary output of 30 mg/kg perorally administered compound in rats ChEMBL. 8093626

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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