Detailed information for compound 594913

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.471 | Formula: C28H31Cl2N3O2
  • H donors: 3 H acceptors: 2 LogP: 6.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(NC1CCC(CC1)N1CCC(CC1)c1c[nH]c2c1cc(O)cc2)/C=C/c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C28H31Cl2N3O2/c29-25-8-1-18(15-26(25)30)2-10-28(35)32-20-3-5-21(6-4-20)33-13-11-19(12-14-33)24-17-31-27-9-7-22(34)16-23(24)27/h1-2,7-10,15-17,19-21,31,34H,3-6,11-14H2,(H,32,35)/b10-2+
  • InChiKey: OKMWVBYFLZHLEM-WTDSWWLTSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0377
Mycobacterium tuberculosis Conserved protein 0.0036 0.0247 0.0918
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Schistosoma mansoni ran 0.0021 0.0061 0.0073
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0006 0.0003
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0009 0.0011
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0061 0.0667
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0129 0.1409
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1293 0.7302
Echinococcus granulosus apoptotic protease activating factor 1 0.0082 0.0835 0.1003
Loa Loa (eye worm) hypothetical protein 0.0029 0.0157 0.0237
Mycobacterium ulcerans hypothetical protein 0.0036 0.0247 0.1395
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0377
Schistosoma mansoni hypothetical protein 0.0305 0.3668 0.4405
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0113 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0369 0.0444
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0006 0.0006
Echinococcus multilocularis allatostatin A receptor 0.0021 0.0064 0.0064
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0747 0.8187
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0747 0.8187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0064 0.0092
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0475 0.1393
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0073 0.0087
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0011
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.003 0.0089
Schistosoma mansoni zinc finger protein 0.0019 0.0036 0.0043
Brugia malayi RE15519p 0.0021 0.0064 0.0099
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0029 0.016 0.0471
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Brugia malayi hypothetical protein 0.0082 0.0835 0.1299
Echinococcus multilocularis neuropeptide receptor A26 0.0021 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0136 0.0205
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0747 0.4217
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0305 0.3668 0.5702
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0247 0.0377
Brugia malayi follicle stimulating hormone receptor 0.0021 0.0064 0.0099
Trypanosoma cruzi metacaspase, putative 0.0088 0.0912 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1303 0.4845
Schistosoma mansoni biogenic amine receptor 0.0021 0.0064 0.0077
Echinococcus granulosus dro:myosuppressin receptor 0.0021 0.0064 0.0077
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0475 0.2185
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0021 0.0064 0.0064
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0053 0.0472 0.0727
Loa Loa (eye worm) hypothetical protein 0.0041 0.0321 0.0493
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0474 0.073
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0073 0.0087
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.1151 0.4282
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0005 0.0005
Brugia malayi Regulator of G protein signaling domain containing protein 0.0052 0.0456 0.0709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Brugia malayi isocitrate dehydrogenase 0.0017 0.0009 0.0014
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0049
Echinococcus multilocularis transfer RNA-Lys 0.0071 0.0702 0.0702
Leishmania major trypanothione reductase 0.0047 0.0389 0.3008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0064 0.0077
Echinococcus granulosus sex peptide receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0037 0.0258 0.0395
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0021 0.0064 0.0092
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0061 0.0344
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0061 0.0344
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Echinococcus multilocularis regulator of G protein signaling 3 0.0052 0.0456 0.0456
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0021 0.0064 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0456 0.1337
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0009 0.0014
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0113 0.1235
Entamoeba histolytica hypothetical protein 0.0039 0.0284 0.0818
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis neuropeptide FF receptor 2 0.0021 0.0064 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3044 0.8933
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Onchocerca volvulus 0.0021 0.0064 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Schistosoma mansoni hypothetical protein 0.0034 0.0221 0.0266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Schistosoma mansoni biogenic amine (5HT) receptor 0.0021 0.0064 0.0077
Mycobacterium tuberculosis Conserved protein 0.0036 0.0247 0.0918
Brugia malayi Bromodomain containing protein 0.0073 0.0721 0.1122
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.109 0.4052
Onchocerca volvulus 0.0089 0.0919 0.3141
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0061 0.0667
Plasmodium falciparum metacaspase 1 0.0088 0.0912 0.5151
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0577 0.0891
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0021 0.0064 0.0064
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.2773 0.4308
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0021 0.0064 0.0099
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0912 0.2676
Echinococcus granulosus regulator of G protein signaling 3 0.0052 0.0456 0.0547
Toxoplasma gondii hypothetical protein 0.0054 0.0475 0.2682
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0456 0.0547
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0089 0.0919 0.3141
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.1293 0.1553
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0136 0.0212
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0369 0.0568
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0006 0.0008
Echinococcus multilocularis G protein coupled receptor kinase 6 0.047 0.5767 0.5767
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Plasmodium vivax metacaspase 1, putative 0.0088 0.0912 0.5151
Brugia malayi Dopamine receptor protein 2 0.0021 0.0064 0.0099
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.003 0.0236
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0021 0.0064 0.0092
Brugia malayi G-protein coupled receptor 0.0021 0.0064 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0369 0.0444
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0088 0.0965
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0113 0.0871
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0029 0.016 0.0471
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0005 0.0006
Leishmania major importin beta-1 subunit, putative 0.0023 0.0088 0.0681
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0377
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0073 0.0073
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0064 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1303 0.7178
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0006 0.0036
Loa Loa (eye worm) glutathione reductase 0.0047 0.0389 0.0598
Mycobacterium ulcerans lipase LipD 0.0036 0.0247 0.1395
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0577 0.0891
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.1559 0.8806
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.016 0.0471
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0011
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1303 0.4845
Echinococcus granulosus intermediate filament protein 0.0027 0.0136 0.0163
Onchocerca volvulus 0.0021 0.0064 0.0198
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0009 0.0052
Echinococcus multilocularis g-protein coupled receptor 0.0021 0.0064 0.0064
Entamoeba histolytica hypothetical protein 0.0023 0.0088 0.024
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.8327 0.8327
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis regulator of G protein signaling 7 0.0052 0.0456 0.0456
Brugia malayi G-protein coupled receptor 0.0021 0.0064 0.0099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0007
Onchocerca volvulus Cell death protein 3 homolog 0.017 0.1953 0.6698
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0232 0.275 0.275
Brugia malayi regulator of G-protein signaling egl-10 0.0052 0.0456 0.0709
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3044 0.8933
Entamoeba histolytica hypothetical protein 0.0052 0.0456 0.1321
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0456 0.0547
Brugia malayi RNA binding protein 0.0062 0.0577 0.0898
Schistosoma mansoni hypothetical protein 0.0021 0.0064 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0912 0.2676
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0389 0.1446
Loa Loa (eye worm) cysteine protease 0.0017 0.0006 0.0003
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.1293 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0021 0.0064 0.0077
Schistosoma mansoni biogenic amine receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0106 0.1146 0.1776
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0747 0.4217
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2041 0.599
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0232 0.275 0.3303
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0247 0.1395
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.003 0.0172
Brugia malayi Cell death protein 3 precursor 0.017 0.1953 0.3039
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.001
Trypanosoma cruzi metacaspase, putative 0.0088 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus allatostatin A receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0021 0.0064 0.0092
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0061 0.0667
Echinococcus granulosus g protein coupled receptor 0.0021 0.0064 0.0077
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0089 0.0919 0.1424
Brugia malayi G protein-coupled receptor 0.0021 0.0064 0.0099
Onchocerca volvulus 0.0027 0.0136 0.0446
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0604 0.6617
Brugia malayi hypothetical protein 0.0075 0.0747 0.1161
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0702
Brugia malayi Serotonin receptor 0.0021 0.0064 0.0099
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0009 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus hypothetical protein 0.0021 0.0064 0.0077
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0021 0.0064 0.0099
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0064 0.0064
Leishmania major metacaspase, putative 0.0088 0.0912 0.7054
Echinococcus multilocularis axis inhibition protein axin 0.0052 0.0456 0.0456
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0389 0.0467
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0021 0.0064 0.0064
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0064 0.0077
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0258 0.0402
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.047 0.5767 0.897
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.0334
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.016 0.0471
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0009 0.0009
Echinococcus granulosus 7TM GPCR rhodopsin 0.0021 0.0064 0.0077
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0577 0.0898
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.1559 0.5798
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Brugia malayi beta-lactamase 0.0036 0.0247 0.0384
Echinococcus multilocularis cysteine protease 0.0017 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0113 0.033
Schistosoma mansoni hypothetical protein 0.0021 0.0064 0.0077
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2689 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0009 0.0101
Entamoeba histolytica hypothetical protein 0.0052 0.0456 0.1321
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0912 0.2676
Toxoplasma gondii thioredoxin reductase 0.0047 0.0389 0.2196
Onchocerca volvulus 0.0025 0.0113 0.0366
Loa Loa (eye worm) hypothetical protein 0.0241 0.2865 0.4453
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0129 0.1409
Echinococcus multilocularis cysteine protease 0.0017 0.0006 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0005 0.0006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0064 0.0064
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0088 0.0912 0.5151
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0021 0.0064 0.0077
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0052 0.0456 0.0547
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0064 0.0077
Entamoeba histolytica hypothetical protein 0.0052 0.0456 0.1321
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Schistosoma mansoni amine GPCR 0.0021 0.0064 0.0077
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.1926 0.6605
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0247 0.0384
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.003 0.003
Echinococcus multilocularis axis inhibition protein axin 0.0052 0.0456 0.0456
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0155 0.1771 0.1771
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0021 0.0064 0.0077
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0026 0.0129 0.1409
Onchocerca volvulus 0.0021 0.0064 0.0198
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0003
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0113 0.0135
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.003 0.0071
Echinococcus granulosus zinc finger protein 0.0019 0.0036 0.0043
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0472 0.0566
Echinococcus granulosus Regulator of G protein signaling 20 0.0052 0.0456 0.0547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0912 0.2676
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0009 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Brugia malayi PHD-finger family protein 0.0024 0.0102 0.0158
Leishmania major cathepsin L-like protease 0.0064 0.0604 0.4668
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.1151 0.4282
Brugia malayi ORL1-like opioid receptor 0.0021 0.0064 0.0099
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Onchocerca volvulus 0.0021 0.0064 0.0198
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0021 0.0064 0.0064
Echinococcus multilocularis snurportin 1 0.0305 0.3668 0.3668
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0064 0.0077
Echinococcus granulosus regulator of G protein signaling 7 0.0052 0.0456 0.0547
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0064 0.0064
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.043 0.4717
Echinococcus granulosus cathepsin l1 0.0017 0.0006 0.0008
Plasmodium vivax vivapain-2 0.0017 0.0006 0.0036
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.3044 0.4735
Loa Loa (eye worm) hypothetical protein 0.0037 0.0268 0.041
Brugia malayi Thioredoxin reductase 0.0047 0.0389 0.0605
Brugia malayi beta-lactamase family protein 0.0036 0.0247 0.0384
Schistosoma mansoni opsin-like receptor 0.0021 0.0064 0.0077
Echinococcus granulosus expressed protein 0.0052 0.0456 0.0547
Entamoeba histolytica hypothetical protein 0.0039 0.0284 0.0818
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Brugia malayi RNA, U transporter 1 0.0081 0.0826 0.1284
Echinococcus multilocularis lamin 0.0027 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0247 0.0918
Echinococcus granulosus tar DNA binding protein 0.0062 0.0577 0.0693
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0247 0.081
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0021 0.0064 0.0077
Brugia malayi A-kinase anchor protein 10, precursor 0.0052 0.0456 0.0709
Plasmodium vivax vivapain-2 0.0017 0.0006 0.0036
Onchocerca volvulus 0.0021 0.0064 0.0198
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.047 0.5767 0.6926
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Echinococcus multilocularis neuropeptides capa receptor 0.0021 0.0064 0.0064
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0088 0.0912 0.1419
Schistosoma mansoni hypothetical protein 0.0039 0.0284 0.0342
Brugia malayi Bromodomain containing protein 0.0037 0.0267 0.0416
Loa Loa (eye worm) hypothetical protein 0.0026 0.013 0.0195
Schistosoma mansoni hypothetical protein 0.0017 0.0009 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0064 0.0064
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0157 0.1718
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0021 0.0064 0.0092
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0912 0.2676
Brugia malayi PXA domain containing protein 0.0052 0.0456 0.0709
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0009 0.0071
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0113 0.0113
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0009 0.0011
Onchocerca volvulus 0.0021 0.0064 0.0198
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1293 0.7302
Schistosoma mansoni intermediate filament proteins 0.0027 0.0136 0.0163
Schistosoma mansoni opsin-like receptor 0.0021 0.0064 0.0077
Schistosoma mansoni hypothetical protein 0.0021 0.0064 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Echinococcus granulosus 7tm_1 domain containing protein 0.0021 0.0064 0.0077
Echinococcus granulosus peptide allatostatin:somatostatin 0.0021 0.0064 0.0077
Onchocerca volvulus 0.0036 0.0247 0.0828
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0247 0.0297
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0247 0.0918
Plasmodium falciparum thioredoxin reductase 0.0047 0.0389 0.2196
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0247 0.0725
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0009 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0005 0.0005
Echinococcus granulosus fmrfamide receptor 0.0021 0.0064 0.0077
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.3408 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0006 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0021 0.0064 0.0064
Leishmania major protein kinase, putative 0.0026 0.0129 0.0994
Brugia malayi regulator of G-protein signaling rgs-7 0.0052 0.0456 0.0709
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Echinococcus multilocularis serotonin receptor 0.0021 0.0064 0.0064
Trypanosoma cruzi metacaspase 5, putative 0.0088 0.0912 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.004 0.0297 0.0456
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Echinococcus granulosus lamin dm0 0.0027 0.0136 0.0163
Entamoeba histolytica Ran family GTPase 0.0021 0.0061 0.016
Schistosoma mansoni single-minded 0.0096 0.1021 0.1226
Toxoplasma gondii cathepsin CPL 0.0017 0.0006 0.0036
Schistosoma mansoni neuropeptide receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis guanylate cyclase, putative 0.0029 0.016 0.0471
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.1293 0.4808
Brugia malayi bHLH-PAS transcription factor 0.0071 0.0702 0.1092
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.1146 0.335
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.016 0.0471
Echinococcus granulosus axis inhibition protein axin 0.0052 0.0456 0.0547
Onchocerca volvulus 0.0021 0.0064 0.0198
Echinococcus multilocularis apoptotic protease activating factor 1 0.0082 0.0835 0.0835
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0284 0.0284
Brugia malayi hypothetical protein 0.0039 0.0284 0.0442
Brugia malayi neuropeptide F receptor 0.0021 0.0064 0.0099
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0064 0.0064
Onchocerca volvulus 0.0071 0.0702 0.2392
Plasmodium falciparum metacaspase-like protein 0.0088 0.0912 0.5151
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trypanosoma brucei metacaspase 5, putative 0.0088 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.0205
Schistosoma mansoni neuropeptide receptor 0.0021 0.0064 0.0077
Brugia malayi PXA domain containing protein 0.0052 0.0456 0.0709
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0474 0.0737
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0604 0.6617
Echinococcus granulosus importin subunit beta 1 0.0029 0.0157 0.0188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0369 0.0369
Echinococcus multilocularis Regulator of G protein signaling 20 0.0052 0.0456 0.0456
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0021 0.0064 0.0198
Echinococcus granulosus tachykinin peptides receptor 99D 0.0021 0.0064 0.0077
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0377
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0006 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.003 0.0172
Brugia malayi G protein-coupled receptor F59B2.13 0.0021 0.0064 0.0099
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0037 0.0258 0.031
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0472 0.0566
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0026 0.0129 0.1409
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0136 0.0205
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0064 0.0064
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0747 0.8187
Loa Loa (eye worm) hypothetical protein 0.0025 0.0113 0.0168
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.003 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Echinococcus multilocularis caspase 8 0.0088 0.0912 0.0912
Loa Loa (eye worm) hypothetical protein 0.0053 0.0474 0.073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0369 0.0369
Echinococcus multilocularis musashi 0.0027 0.0136 0.0136
Schistosoma mansoni importin beta-1 0.0029 0.0157 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0456 0.1337
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.1146 0.335
Loa Loa (eye worm) RNA binding protein 0.0062 0.0577 0.0891
Onchocerca volvulus 0.0021 0.0064 0.0198
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3044 0.8933
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1293 0.1553
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0009 0.0052
Brugia malayi Adenylyl cyclase protein 0.0089 0.0919 0.143
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.3408 1
Schistosoma mansoni caspase-7 (C14 family) 0.0232 0.275 0.3303
Brugia malayi PAS domain containing protein 0.0096 0.1021 0.1587
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0247 0.0725
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.0089
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0021 0.0064 0.0077
Echinococcus granulosus regulator of G protein signaling 7 0.0052 0.0456 0.0547
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0021 0.0064 0.0099
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0061 0.0073
Echinococcus granulosus neuropeptide receptor 0.0021 0.0064 0.0077
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 1
Schistosoma mansoni caspase-3 (C14 family) 0.0232 0.275 0.3303
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0088 0.0258
Trypanosoma brucei trypanothione reductase 0.0047 0.0389 0.4264
Onchocerca volvulus 0.0021 0.0064 0.0198
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0006 0.0008
Echinococcus multilocularis beta adrenergic receptor kinase 0.0053 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0702
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0475 0.2682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Brugia malayi hypothetical protein 0.0052 0.0456 0.0709
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0052 0.0456 0.0547
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 1
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0064 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0247 0.2707
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0221 0.0221
Schistosoma mansoni amine GPCR 0.0021 0.0064 0.0077
Trypanosoma brucei metacaspase MCA2 0.0088 0.0912 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.001
Echinococcus multilocularis somatostatin receptor 0.0021 0.0064 0.0064
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 1
Brugia malayi hypothetical protein 0.0324 0.391 0.6081
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0009 0.0009
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.047 0.5767 0.897
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1303 0.4845
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0009 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0113 0.033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0369 0.0444
Echinococcus granulosus caspase 8 0.0088 0.0912 0.1095
Onchocerca volvulus 0.0036 0.0247 0.0828
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.1151 0.4282
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3044 0.8933
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0052 0.0456 0.0702
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Leishmania major hypothetical protein, conserved 0.0075 0.0747 0.5775
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0006 0.0036
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0475 0.2682
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3044 0.8933
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Echinococcus multilocularis regulator of G protein signaling 3 0.0052 0.0456 0.0456
Onchocerca volvulus Neuropeptide F receptor homolog 0.0021 0.0064 0.0198
Echinococcus granulosus neuropeptide receptor 0.0021 0.0064 0.0077
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.109 0.4052
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0088
Schistosoma mansoni hypothetical protein 0.0082 0.0835 0.1003
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0106 0.1146 0.392
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0088 0.0258
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0247 0.0297
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0474 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Trypanosoma brucei metacaspase 0.0088 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0702
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0009 0.0052
Leishmania major cathepsin L-like protease 0.0064 0.0604 0.4668
Echinococcus granulosus neuropeptide Y receptor 0.0021 0.0064 0.0077
Echinococcus granulosus caspase 2 0.017 0.1953 0.2346
Schistosoma mansoni ap endonuclease 0.0019 0.003 0.0037
Echinococcus multilocularis expressed protein 0.0052 0.0456 0.0456
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0088 0.0912 0.1095
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0155 0.1771 1
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0049
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.3044 0.4731
Mycobacterium ulcerans putative regulatory protein 0.0071 0.0702 0.3963
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0021 0.0064 0.0064
Echinococcus granulosus beta-adrenergic receptor kinase 0.0053 0.0472 0.0566
Echinococcus granulosus regulator of G protein signaling 3 0.0052 0.0456 0.0547
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Onchocerca volvulus 0.0021 0.0064 0.0198
Leishmania major cathepsin L-like protease 0.0064 0.0604 0.4668
Echinococcus multilocularis adenylate cyclase 9 0.0089 0.0919 0.0919
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0005 0.0006
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0006 0.0006
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0025 0.0113 0.0636
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Brugia malayi glutathione reductase 0.0047 0.0389 0.0605
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0009 0.0101
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.3408 1
Echinococcus granulosus g-protein coupled receptor 0.0021 0.0064 0.0077
Schistosoma mansoni ran 0.0021 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0456 0.1337
Echinococcus granulosus GPCR family 2 0.0017 0.0009 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0577 0.0693
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.003 0.0047
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.047 0.5767 0.897
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.001
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0247 0.1395
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.2773 0.4308
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0747 0.4217
Plasmodium falciparum importin beta, putative 0.0029 0.0157 0.0885
Echinococcus granulosus g protein coupled receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0021 0.0064 0.0099
Loa Loa (eye worm) hypothetical protein 0.0155 0.1771 0.2749
Onchocerca volvulus 0.0021 0.0064 0.0198
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.8327 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0049 0.0069
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0247 0.0918
Plasmodium falciparum glutathione reductase 0.0047 0.0389 0.2196
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0049
Mycobacterium leprae Probable lipase LipE 0.0036 0.0247 0.081
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0577 0.0693
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0377
Loa Loa (eye worm) hypothetical protein 0.0088 0.0912 0.1412
Brugia malayi neuropeptide F receptor 0.0021 0.0064 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0049
Brugia malayi HSF-type DNA-binding domain containing protein 0.0106 0.1146 0.1782
Schistosoma mansoni axis inhibition protein axin 0.0052 0.0456 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0456 0.1337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0577 0.0577
Schistosoma mansoni amine GPCR 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0369 0.0575
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0061 0.0344
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0245 0.2913 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0157 0.0885
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.1559 0.8725
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.1151 0.6265
Echinococcus granulosus caspase 3 0.0145 0.1632 0.196
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0006 0.0036
Schistosoma mansoni aryl hydrocarbon receptor 0.0096 0.1021 0.1226
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0009 0.0011
Echinococcus multilocularis fmrfamide receptor 0.0021 0.0064 0.0064
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0009 0.0052
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0247 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0247 0.0725
Echinococcus granulosus G protein coupled receptor 139 0.0021 0.0064 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0247 0.0725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0604 0.6617
Echinococcus multilocularis neuropeptide Y receptor 0.0021 0.0064 0.0064
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0052 0.0456 0.0547
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0006 0.0006
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0577 0.0693
Brugia malayi Dopamine receptor 0.0021 0.0064 0.0099
Brugia malayi AKH receptor 0.0021 0.0064 0.0099
Leishmania major GTP-binding protein, putative 0.0021 0.0061 0.0471
Schistosoma mansoni growth hormone secretagogue receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0009 0.0009
Echinococcus multilocularis serotonin receptor 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus serotonin receptor 0.0021 0.0064 0.0077
Entamoeba histolytica hypothetical protein 0.0039 0.0284 0.0818
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0247 0.2707
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.003 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0064 0.0077
Leishmania major hypothetical protein, conserved 0.0036 0.0247 0.191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Loa Loa (eye worm) PXA domain-containing protein 0.0052 0.0456 0.0702
Schistosoma mansoni z-protein (S1r protein) 0.0052 0.0456 0.0547
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0247 0.0725
Loa Loa (eye worm) hypothetical protein 0.0036 0.0247 0.0377
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0006 0.001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis geminin 0.0336 0.4067 0.4067
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0113 0.1235
Brugia malayi putative neuropeptide receptor NPR1 0.0021 0.0064 0.0099
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.003 0.0089
Brugia malayi MH2 domain containing protein 0.0234 0.2773 0.4313
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0052 0.0456 0.0547
Mycobacterium tuberculosis Probable reductase 0.0107 0.1151 0.4282
Echinococcus granulosus snurportin 1 0.0305 0.3668 0.4405
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0006 0.0008
Brugia malayi sulfakinin receptor protein 0.0021 0.0064 0.0099
Schistosoma mansoni axis inhibition protein axin 0.0052 0.0456 0.0547
Loa Loa (eye worm) melatonin receptor type 1A 0.0021 0.0064 0.0092
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0389 0.0389
Echinococcus multilocularis G protein coupled receptor 139 0.0021 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0702
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0247 0.0247
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0284 0.0342
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.109 0.109
Brugia malayi Cathepsin L-like precursor 0.0017 0.0006 0.001
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.1293 0.2011
Onchocerca volvulus 0.0021 0.0064 0.0198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Brugia malayi Importin beta-1 subunit 0.0029 0.0157 0.0244
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0155 0.1771 0.2127
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0064 0.0064
Echinococcus granulosus microtubule associated protein 2 0.0671 0.8327 1
Onchocerca volvulus 0.0036 0.0247 0.0828
Echinococcus multilocularis caspase 0.0232 0.275 0.275
Schistosoma mansoni neuropeptide receptor 0.0021 0.0064 0.0077
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0456 0.0547
Echinococcus multilocularis regulator of G protein signaling 0.0052 0.0456 0.0456
Brugia malayi hypothetical protein 0.0052 0.0456 0.0709
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Echinococcus granulosus somatostatin receptor 0.0021 0.0064 0.0077
Plasmodium vivax importin-beta 2, putative 0.0029 0.0157 0.0885
Echinococcus granulosus geminin 0.0336 0.4067 0.4885
Schistosoma mansoni bromodomain containing protein 0.0062 0.0576 0.0692
Loa Loa (eye worm) hypothetical protein 0.0082 0.0835 0.1293
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0577 0.0693
Trichomonas vaginalis esterase, putative 0.0036 0.0247 0.0725
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0009 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Trichomonas vaginalis ran, putative 0.0021 0.0061 0.0179
Echinococcus granulosus neuropeptide s receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis adenylate cyclase, putative 0.0029 0.016 0.0471
Onchocerca volvulus 0.0021 0.0064 0.0198
Brugia malayi intermediate filament protein 0.0027 0.0136 0.0212
Brugia malayi hypothetical protein 0.0021 0.0064 0.0099
Echinococcus granulosus neuropeptide receptor A26 0.0021 0.0064 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.003 0.0334
Schistosoma mansoni hypothetical protein 0.0021 0.0064 0.0077
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0247 0.0918
Schistosoma mansoni neuropeptide F-like receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.003 0.004
Echinococcus granulosus caspase 0.0232 0.275 0.3303
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.003 0.0113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Onchocerca volvulus 0.0021 0.0064 0.0198
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0456 0.0547
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0604 0.6617
Brugia malayi beta-lactamase family protein 0.0036 0.0247 0.0384
Trypanosoma cruzi metacaspase 5, putative 0.0088 0.0912 1
Echinococcus multilocularis caspase 3 0.0145 0.1632 0.1632
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0157 0.0157
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0088 0.0258
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0012 0.0012
Plasmodium vivax hypothetical protein, conserved 0.0088 0.0912 0.5151
Echinococcus multilocularis neuropeptide s receptor 0.0021 0.0064 0.0064
Brugia malayi TAR-binding protein 0.0062 0.0577 0.0898
Schistosoma mansoni alpha-1 adrenergic receptor 0.0021 0.0064 0.0077
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0009 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0069 0.0668 0.1033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0369 0.0444
Echinococcus granulosus g protein coupled receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0324 0.391 0.6078
Echinococcus multilocularis orexin receptor type 2 0.0021 0.0064 0.0064
Loa Loa (eye worm) neuropeptide F receptor 0.0021 0.0064 0.0092
Toxoplasma gondii exonuclease III APE 0.0019 0.003 0.0172
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0604 0.6617
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0009 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Echinococcus multilocularis GPCR, family 2 0.0017 0.0009 0.0009
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0221 0.0266
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Schistosoma mansoni histamine h1 receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis g protein coupled receptor 0.0021 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0912 0.2676
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0009 0.0014
Echinococcus multilocularis regulator of G protein signaling 7 0.0052 0.0456 0.0456
Schistosoma mansoni adenoreceptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0702
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0006 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Schistosoma mansoni opsin-like receptor 0.0021 0.0064 0.0077
Onchocerca volvulus 0.0085 0.0872 0.2976
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.3408 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0021 0.0064 0.0077
Brugia malayi putative neuropeptide receptor 0.0021 0.0064 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.1151 0.4282
Loa Loa (eye worm) hypothetical protein 0.0052 0.0456 0.0702
Brugia malayi hypoxia-induced factor 1 0.0299 0.3591 0.5585
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0113 0.033
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.1926 0.5653
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1293 0.1293
Loa Loa (eye worm) RGS-3 protein 0.0052 0.0456 0.0702
Echinococcus multilocularis caspase 2 0.017 0.1953 0.1953
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0247 0.1395
Brugia malayi Serotonin receptor 0.0021 0.0064 0.0099
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0247 0.0918
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0009 0.0009
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0021 0.0064 0.0064
Brugia malayi hypothetical protein 0.0048 0.0409 0.0636
Brugia malayi Dopamine receptor protein 1 0.0021 0.0064 0.0099
Onchocerca volvulus 0.0027 0.0136 0.0446
Entamoeba histolytica hypothetical protein 0.0039 0.0284 0.0818
Echinococcus multilocularis G-protein coupled receptor, putative 0.0021 0.0064 0.0064
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0247 0.0918
Brugia malayi larval opioid receptor 0.0021 0.0064 0.0099
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0577 0.0693
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0522 0.6429 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0006 0.0069
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0113 0.0113
Schistosoma mansoni serine/threonine protein kinase 0.0522 0.6429 0.7721
Onchocerca volvulus 0.0021 0.0064 0.0198
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0009 0.0014
Loa Loa (eye worm) adenylyl cyclase 3 0.0089 0.0919 0.1424
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0021 0.0064 0.0077
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis lamin dm0 0.0027 0.0136 0.0136
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.003 0.0089
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0021 0.0064 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0369 0.0444
Entamoeba histolytica heat shock transcription factor, putative 0.0106 0.1146 0.335
Mycobacterium ulcerans beta-lactamase 0.0036 0.0247 0.1395
Loa Loa (eye worm) hypothetical protein 0.017 0.1953 0.3034
Echinococcus granulosus tm gpcr rhodopsin 0.0021 0.0064 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0157 0.1718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0021 0.0064 0.0077
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.3408 1
Schistosoma mansoni lamin 0.0027 0.0136 0.0163
Schistosoma mansoni caspase-7 (C14 family) 0.017 0.1953 0.2346
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.2041 0.599
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0006
Onchocerca volvulus 0.0021 0.0064 0.0198
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0113 0.0168
Trypanosoma cruzi metacaspase, putative 0.0088 0.0912 1
Brugia malayi Melatonin receptor type 1A 0.0021 0.0064 0.0099
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0029 0.016 0.0471
Echinococcus granulosus neuropeptides capa receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0006 0.0006
Loa Loa (eye worm) beta-lactamase 0.0036 0.0247 0.0377
Onchocerca volvulus 0.0021 0.0064 0.0198
Toxoplasma gondii ABC1 family protein 0.0036 0.0247 0.1395
Trypanosoma cruzi metacaspase, putative 0.0088 0.0912 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0088 0.0912 0.5151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0389 0.4264
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0456 0.1337
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0006 0.0008
Schistosoma mansoni lamin 0.0027 0.0136 0.0163
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0522 0.6429 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0021 0.0064 0.0077
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0021 0.0064 0.0099
Loa Loa (eye worm) TYRA-2 protein 0.0021 0.0064 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0006 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0533 0.5847
Schistosoma mansoni amine GPCR 0.0021 0.0064 0.0077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0238 0.0286
Leishmania major protein kinase, putative 0.0026 0.0129 0.0994
Mycobacterium tuberculosis Conserved protein 0.0036 0.0247 0.0918
Echinococcus multilocularis neuropeptide receptor 0.0021 0.0064 0.0064
Leishmania major cathepsin L-like protease 0.0017 0.0006 0.0049
Loa Loa (eye worm) G-protein coupled receptor 0.0021 0.0064 0.0092
Schistosoma mansoni hypothetical protein 0.0336 0.4067 0.4885
Schistosoma mansoni biogenic amine receptor 0.0021 0.0064 0.0077
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0088 0.0912 0.2676
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0006 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0005 0.0006
Brugia malayi GnHR receptor homolog 0.0021 0.0064 0.0099
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0021 0.0064 0.0077
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0172
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0021 0.0064 0.0064
Schistosoma mansoni neuropeptide receptor 0.0021 0.0064 0.0077
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0532 0.0639
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0021 0.0064 0.0077
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0532 0.0532
Brugia malayi Regulator of G protein signaling domain containing protein 0.0052 0.0456 0.0709
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0747 0.4217
Loa Loa (eye worm) hypothetical protein 0.0075 0.0747 0.1155
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Echinococcus multilocularis sex peptide receptor 0.0021 0.0064 0.0064
Trypanosoma brucei Metacaspase-4 0.0088 0.0912 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0021 0.0064 0.0077
Schistosoma mansoni peptidase Clp (S14 family) 0.0155 0.1771 0.2127
Trypanosoma brucei metacaspase MCA3 0.0088 0.0912 1
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0059
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.1151 0.4282
Echinococcus multilocularis dro:myosuppressin receptor 0.0021 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0456 0.1337
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0021 0.0064 0.0077
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0061 0.0061
Echinococcus granulosus adenylate cyclase 9 0.0089 0.0919 0.1104
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0009 0.0101
Echinococcus multilocularis zinc finger protein 0.0019 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0021 0.0064 0.0077
Plasmodium vivax glutathione reductase, putative 0.0047 0.0389 0.2196
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0021 0.0064 0.0092
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0106 0.1146 0.1777
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0389 0.2196
Echinococcus granulosus rhodopsin orphan GPCR 0.0021 0.0064 0.0077
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0052 0.0456 0.0456
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0155 0.1771 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0155 0.1771 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0299 0.3591 0.5582
Loa Loa (eye worm) fibroinase 0.0017 0.0006 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0284 0.0342
Schistosoma mansoni hypothetical protein 0.0336 0.4067 0.4885
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0052 0.0456 0.1337
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0155 0.1771 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.003 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0006 0.0018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0247 0.0918
Schistosoma mansoni regulator of G protein signaling 0.0052 0.0456 0.0547
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.109 0.5892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0006 0.0018
Echinococcus granulosus axis inhibition protein axin 0.0052 0.0456 0.0547
Onchocerca volvulus 0.0082 0.0835 0.2852
Echinococcus granulosus lamin 0.0027 0.0136 0.0163
Echinococcus granulosus orexin receptor type 2 0.0021 0.0064 0.0077
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0088 0.0912 0.5151
Brugia malayi Probable ClpP-like protease 0.0155 0.1771 0.2754
Schistosoma mansoni myosin xvIII 0.0021 0.0064 0.0077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0064 0.0092
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0155 0.1771 0.5196
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.3044 0.8933
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0247 0.2707
Echinococcus granulosus single minded 2 0.0071 0.0702 0.0843
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0389 0.0598
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.109 0.1309

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 1.52 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 1.81 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 2.5 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 10 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 16 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 97 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 2.96 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -9 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 10 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 16 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 97 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.04 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 0.92091 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.