Detailed information for compound 595208

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 322.318 | Formula: C17H14N4O3
  • H donors: 1 H acceptors: 3 LogP: 3.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1nccc2NN=Cc1ccc(cc1)N(=O)=O
  • InChi: 1S/C17H14N4O3/c1-24-16-4-2-3-14-15(9-10-18-17(14)16)20-19-11-12-5-7-13(8-6-12)21(22)23/h2-11H,1H3,(H,18,20)
  • InChiKey: ULRHCDGMLCHGPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lachesin 0.0041 0.0027 0.0028
Echinococcus multilocularis serine:threonine protein kinase N2 0.0045 0.0065 0.0067
Trypanosoma cruzi cdc2-related kinase 1 0.0066 0.0268 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0044 0.0045
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0164 0.1212 0.1212
Schistosoma mansoni tyrosine kinase 0.0046 0.0078 0.0081
Echinococcus multilocularis cyclin dependent kinase 5 0.0066 0.0268 0.0275
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.1047 0.9744 1
Trichomonas vaginalis STE family protein kinase 0.0186 0.1431 0.143
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2019 0.2072
Schistosoma mansoni protein kinase 0.0099 0.0587 0.0602
Loa Loa (eye worm) gastrulation defective protein 1 0.015 0.1078 0.1078
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0041 0.0027 0.0028
Echinococcus multilocularis activin receptor type 0.0464 0.4112 0.422
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0126 0.085 0.0873
Echinococcus multilocularis cyclin dependent kinase 1 0.0066 0.0268 0.0275
Echinococcus multilocularis Immunoglobulin 0.0088 0.0483 0.0496
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.1047 0.9744 0.9744
Schistosoma mansoni tyrosine kinase 0.0096 0.0554 0.0569
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0221 0.1764 0.1774
Echinococcus granulosus Immunoglobulin 0.0088 0.0483 0.0496
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.2451 0.2481
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0208 0.1645 0.1688
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0161 0.1186 0.1178
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0141 0.0993 0.1019
Loa Loa (eye worm) hypothetical protein 0.0247 0.2019 0.2019
Schistosoma mansoni tyrosine kinase 0.0067 0.0281 0.0288
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0153 0.1107 0.1107
Schistosoma mansoni protein kinase 0.0201 0.1576 0.1617
Entamoeba histolytica cell division protein kinase 2, putative 0.0066 0.0268 0.027
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0073 0.003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0292 0.2451 0.2481
Echinococcus multilocularis roundabout 2 0.0045 0.0067 0.0069
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0189
Echinococcus multilocularis 0.1047 0.9744 1
Echinococcus granulosus activated cdc42 kinase 1 0.0218 0.1737 0.1782
Entamoeba histolytica protein kinase domain containing protein 0.0221 0.1764 0.1806
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0149 0.107 0.107
Trichomonas vaginalis AGC family protein kinase 0.0145 0.1036 0.1023
Brugia malayi Serine/threonine-protein kinase SULU 0.0233 0.1882 0.1882
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.011 0.0697 0.0697
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0058 0.0189 0.0194
Echinococcus granulosus neuroglian 0.0045 0.0067 0.0069
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0126 0.085 0.085
Loa Loa (eye worm) hypothetical protein 0.0052 0.0136 0.0136
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0145 0.1036 0.1063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0105 0.0105
Brugia malayi SRC-1 0.0097 0.057 0.057
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0085 0.0458 0.0458
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Plasmodium vivax protein kinase Crk2 0.0066 0.0268 0.0202
Echinococcus granulosus tyrosine kinase 0.0049 0.0106 0.0109
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0042 0.0043
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0182 0.1386 0.1423
Schistosoma mansoni titin 0.0046 0.0078 0.008
Plasmodium falciparum casein kinase 1 0.006 0.0212 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.006 0.0062
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0221 0.1764 0.1774
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0081 0.0081
Schistosoma mansoni tyrosine kinase 0.0178 0.1346 0.1382
Onchocerca volvulus 0.0054 0.0152 0.0125
Loa Loa (eye worm) hypothetical protein 0.0119 0.0778 0.0778
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0153 0.1107 0.1107
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.1047 0.9744 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0092 0.0523 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1126 0.1155
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0065 0.0067
Schistosoma mansoni protein kinase 0.0145 0.1036 0.1063
Entamoeba histolytica protein kinase, putative 0.0221 0.1764 0.1806
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0045 0.0068 0.0025
Echinococcus granulosus dual specificity 0.0221 0.1764 0.1811
Brugia malayi Protein kinase domain containing protein 0.0049 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0233 0.0239
Brugia malayi Temporarily assigned gene name protein 59 0.0058 0.0189 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.022 0.0225
Brugia malayi P38 map kinase family protein 2 0.0161 0.1186 0.1186
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0152 0.0152
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0149 0.107 0.107
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0212 0.0212
Leishmania major casein kinase, putative 0.006 0.0212 0.0174
Loa Loa (eye worm) hypothetical protein 0.0108 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0204 0.1602 0.1602
Echinococcus granulosus c-Jun N-terminal kinases 0.0281 0.2346 0.2408
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Brugia malayi casein kinase I 0.006 0.0212 0.0212
Echinococcus multilocularis tyrosine protein kinase Blk 0.0083 0.0429 0.0441
Loa Loa (eye worm) hypothetical protein 0.0087 0.0475 0.0475
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0469 0.0439
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0199 0.1557 0.1598
Trichomonas vaginalis AGC family protein kinase 0.0145 0.1036 0.1023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0081 0.0083
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0145 0.1036 0.0995
Entamoeba histolytica protein kinase, putative 0.006 0.0211 0.0211
Echinococcus granulosus cyclin dependent kinase 5 0.0066 0.0268 0.0275
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0834 0.7681 0.7883
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0045 0.0065 0.0067
Schistosoma mansoni tyrosine kinase 0.0265 0.2193 0.2251
Schistosoma mansoni serine/threonine protein kinase 0.0167 0.1241 0.1274
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0161 0.1186 0.1178
Echinococcus granulosus cyclin dependent kinase 1 0.0066 0.0268 0.0275
Echinococcus granulosus Vam6:Vps39 protein 0.0058 0.0189 0.0194
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0083
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0066 0.0268 0.0275
Echinococcus granulosus casein kinase I alpha 0.006 0.0212 0.0218
Brugia malayi hypothetical protein 0.0119 0.0778 0.0778
Brugia malayi Protein kinase domain containing protein 0.0201 0.1576 0.1576
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0182 0.1386 0.1423
Echinococcus multilocularis protein kinase shaggy 0.0126 0.085 0.0873
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0043 0.0044 0.0044
Leishmania major protein kinase, putative 0.006 0.0211 0.0172
Echinococcus multilocularis twitchin 0.0042 0.0039 0.004
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0281 0.2346 0.2408
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0268 0.0275
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0062 0.023 0.023
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.1047 0.9744 1
Entamoeba histolytica protein kinase, putative 0.0145 0.1036 0.1058
Schistosoma mansoni tyrosine kinase 0.0064 0.0247 0.0254
Schistosoma mansoni hypothetical protein 0.0101 0.0603 0.0619
Brugia malayi protein-tyrosine kinase 0.0083 0.0429 0.0429
Trypanosoma cruzi casein kinase, putative 0.006 0.0212 0.0174
Entamoeba histolytica protein kinase domain containing protein 0.0045 0.0068 0.0064
Echinococcus granulosus cyclin dependent kinase 7 0.0105 0.0644 0.0661
Echinococcus granulosus cyclin dependent kinase 9 0.0068 0.0292 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0678 0.0696
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Echinococcus multilocularis mitogen activated protein kinase 14 0.0161 0.1186 0.1218
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Schistosoma mansoni serine/threonine protein kinase 0.0281 0.2346 0.2408
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0211 0.0216
Echinococcus multilocularis cyclin dependent kinase 0.0066 0.0268 0.0275
Echinococcus multilocularis serine:threonine protein kinase N2 0.0045 0.0065 0.0067
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Loa Loa (eye worm) TK protein kinase 0.0083 0.0429 0.0429
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0233 0.1882 0.1882
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0097 0.057 0.0585
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0155 0.1126 0.1115
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Mycobacterium tuberculosis Conserved hypothetical protein 0.0325 0.2769 0.6662
Schistosoma mansoni protein kinase 0.0187 0.1435 0.1473
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0027 0.0027
Loa Loa (eye worm) acetyltransferase 0.0155 0.1133 0.1133
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0066 0.0268 0.0231
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0126 0.085 0.0832
Echinococcus multilocularis cyclin dependent kinase 1 0.0066 0.0268 0.0275
Echinococcus granulosus tyrosine kinase 0.0083 0.0429 0.0441
Onchocerca volvulus Huntingtin homolog 0.0119 0.0778 0.0753
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0536 0.4808 0.4808
Giardia lamblia Kinase, CMGC CLK 0.0155 0.1126 0.1122
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0054 0.0149 0.0153
Trypanosoma brucei cdc2-related kinase 1 0.0066 0.0268 0.0231
Entamoeba histolytica protein kinase domain containing protein 0.0145 0.1036 0.1058
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0201 0.1576 0.1576
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0145 0.1036 0.1058
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0653 0.0628
Trichomonas vaginalis AGC family protein kinase 0.0145 0.1036 0.1023
Entamoeba histolytica protein kinase, putative 0.0221 0.1764 0.1806
Brugia malayi Protein kinase domain containing protein 0.0045 0.0065 0.0065
Brugia malayi intracellular kinase 0.0126 0.085 0.085
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0186 0.1431 0.1431
Echinococcus multilocularis casein kinase I alpha 0.006 0.0212 0.0218
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0092 0.0519 0.0533
Loa Loa (eye worm) CMGC/CDK/CDK7 protein kinase 0.0105 0.0644 0.0644
Echinococcus granulosus roundabout 2 0.0045 0.0067 0.0069
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0147 0.1052 0.1052
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0127 0.0857 0.0857
Echinococcus granulosus histone acetyltransferase KAT2B 0.0151 0.1091 0.1119
Brugia malayi Protein kinase domain containing protein 0.0049 0.0106 0.0106
Echinococcus multilocularis dual specificity 0.0221 0.1764 0.1811
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0049 0.0106 0.0109
Onchocerca volvulus 0.0357 0.3076 0.3057
Echinococcus multilocularis tyrosine protein kinase HCK 0.0062 0.0229 0.0235
Loa Loa (eye worm) TK/ABL protein kinase 0.0286 0.2394 0.2394
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.006 0.0211 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0078 0.008
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0216 0.1718 0.1763
Leishmania major protein kinase, putative 0.0155 0.1126 0.1115
Brugia malayi plexin A 0.0038 0.0003 0.0003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0083 0.0429 0.0441
Loa Loa (eye worm) hypothetical protein 0.0092 0.0523 0.0523
Echinococcus granulosus cyclin dependent kinase 19 0.0167 0.1241 0.1274
Brugia malayi Protein kinase domain containing protein 0.0155 0.1126 0.1126
Trichomonas vaginalis CAMK family protein kinase 0.006 0.0211 0.0172
Schistosoma mansoni serine/threonine protein kinase 0.0221 0.1764 0.1811
Echinococcus multilocularis protein kinase c iota type 0.0062 0.0233 0.0239
Echinococcus multilocularis c src tyrosine kinase 0.0064 0.0247 0.0254
Loa Loa (eye worm) hypothetical protein 0.0091 0.0513 0.0513
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0281 0.2346 0.2346
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0097 0.057 0.0585
Loa Loa (eye worm) plexin A 0.0038 0.0003 0.0003
Echinococcus granulosus tyrosine protein kinase Lyn 0.0114 0.0733 0.0752
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.1107 0.1136
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Schistosoma mansoni neuroglian 0.0045 0.0067 0.0069
Loa Loa (eye worm) hypothetical protein 0.0082 0.0424 0.0424
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0045 0.0068 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0155 0.1126 0.1155
Brugia malayi intermediate filament protein 0.0054 0.0152 0.0152
Schistosoma mansoni protein kinase 0.0045 0.0068 0.007
Schistosoma mansoni septate junction protein 0.0041 0.0027 0.0028
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0221 0.1764 0.1774
Trypanosoma cruzi casein kinase, putative 0.006 0.0212 0.0174
Entamoeba histolytica hypothetical protein 0.0221 0.1764 0.1806
Trypanosoma cruzi casein kinase, delta isoform, putative 0.006 0.0212 0.0174
Entamoeba histolytica acetyltransferase, GNAT family 0.0042 0.0037 0.0032
Onchocerca volvulus 0.0058 0.0189 0.0162
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0097 0.057 0.0585
Echinococcus granulosus casein kinase I delta 0.006 0.0212 0.0218
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0065 0.0022
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0087 0.047 0.047
Schistosoma mansoni protein kinase 0.0045 0.0068 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0268 0.0231
Onchocerca volvulus 0.0167 0.1243 0.1219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0081 0.0083
Echinococcus multilocularis rho associated protein kinase 0.0184 0.1406 0.1443
Plasmodium falciparum calcium-dependent protein kinase 3 0.006 0.0211 0.0179
Loa Loa (eye worm) TK/EGFR protein kinase 0.0096 0.0554 0.0554
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0126 0.085 0.0832
Entamoeba histolytica protein kinase, putative 0.0126 0.085 0.0867
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0161 0.1186 0.1186
Loa Loa (eye worm) hypothetical protein 0.007 0.0307 0.0307
Echinococcus granulosus TGF-beta receptor type-1 0.0099 0.0587 0.0602
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0045 0.0067 0.0069
Schistosoma mansoni tyrosine kinase 0.0101 0.0611 0.0627
Schistosoma mansoni tyrosine kinase 0.0097 0.057 0.0585
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0617 0.5588 0.5715
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.006 0.0211 0.0172
Echinococcus granulosus tyrosine protein kinase ABL1 0.0286 0.2394 0.2456
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0104 0.0638 0.0638
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0126 0.085 0.0832
Echinococcus granulosus tyrosine protein kinase Src64B 0.0097 0.057 0.0585
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.057 0.0585
Schistosoma mansoni alpha-glucosidase 0.0142 0.1002 0.1028
Giardia lamblia Kinase, AGC PKA 0.0108 0.0678 0.0661
Schistosoma mansoni survival motor neuron protein 0.005 0.0119 0.0122
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1223 0.1223
Schistosoma mansoni vesicular amine transporter 0.0088 0.0483 0.0496
Echinococcus granulosus calcium dependent protein kinase 0.0043 0.0048 0.0049
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0045 0.0065 0.0067
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0152 0.0152
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Brugia malayi Cam kinase protein 1 0.006 0.0211 0.0211
Toxoplasma gondii hypothetical protein 0.0099 0.0593 0.0566
Echinococcus multilocularis cyclin dependent kinase 19 0.0167 0.1241 0.1274
Echinococcus multilocularis activated cdc42 kinase 1 0.0218 0.1737 0.1782
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0043 0.0049 0.0006
Echinococcus multilocularis protein kinase c epsilon type 0.0062 0.0233 0.0239
Echinococcus multilocularis GPCR, family 2 0.0047 0.0081 0.0083
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0153 0.1107 0.1136
Schistosoma mansoni tyrosine kinase 0.0096 0.0554 0.0569
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.085 0.0867
Echinococcus granulosus titin 0.0046 0.0078 0.008
Toxoplasma gondii AGC kinase 0.0045 0.0065 0.0022
Echinococcus multilocularis dual specificity mitogen activated protein 0.0186 0.1431 0.1469
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0153 0.0112
Brugia malayi protein unc-22 0.0046 0.0078 0.0078
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0155 0.1133 0.1162
Brugia malayi hypothetical protein 0.007 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0089 0.0488 0.0488
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.0292 0.03
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0519 0.0533
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0219 0.018
Loa Loa (eye worm) SRC-1 0.0097 0.057 0.057
Schistosoma mansoni serine/threonine protein kinase 0.0046 0.0073 0.0075
Loa Loa (eye worm) hypothetical protein 0.0159 0.1163 0.1163
Schistosoma mansoni cell adhesion molecule 0.0108 0.0675 0.0692
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.1047 0.9744 1
Brugia malayi Protein kinase domain containing protein 0.0221 0.1764 0.1764
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0187 0.1435 0.1473
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0046 0.0078 0.0078
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0045 0.0065 0.0067
Loa Loa (eye worm) CAMK protein kinase 0.0046 0.0078 0.0078
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0155 0.1126 0.1115
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0226 0.1818 0.1818
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0096 0.0554 0.0569
Loa Loa (eye worm) hypothetical protein 0.0053 0.0143 0.0143
Brugia malayi hypothetical protein 0.0092 0.0523 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0199 0.1557 0.1598
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0045 0.0068 0.0025
Echinococcus multilocularis TGF beta receptor type 1 0.0099 0.0587 0.0602
Loa Loa (eye worm) hypothetical protein 0.0119 0.0778 0.0778
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Loa Loa (eye worm) TK/FAK protein kinase 0.0321 0.273 0.273
Schistosoma mansoni tyrosine kinase 0.0178 0.1346 0.1382
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0152 0.0152
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0062 0.0233 0.0239
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.006 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0122 0.0814 0.0836
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0398 0.0408
Giardia lamblia Kinase, CMGC GSK 0.0126 0.085 0.0838
Brugia malayi acetyltransferase, GNAT family protein 0.0155 0.1133 0.1133
Trypanosoma brucei cdc2-related kinase 3 0.0066 0.0268 0.0231
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0155 0.1126 0.1115
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.006 0.0211 0.0216
Echinococcus multilocularis hemicentin 1 0.0041 0.0027 0.0028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.006 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0268 0.0275
Brugia malayi cell division control protein 2 homolog 0.0066 0.0268 0.0268
Entamoeba histolytica PH domain containing protein kinase, putative 0.0112 0.0716 0.0729
Brugia malayi serine/threonine-protein kinase 6 0.0145 0.1036 0.1036
Echinococcus multilocularis titin 0.0046 0.0078 0.008
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0066 0.0268 0.0231
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0042 0.0043
Echinococcus granulosus TGF beta receptor type 1 0.0099 0.0587 0.0602
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.1047 0.9744 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0189
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0644 0.0661
Onchocerca volvulus 0.0046 0.0078 0.0051
Echinococcus granulosus cyclin dependent kinase 0.0066 0.0268 0.0275
Echinococcus granulosus raf serine:threonine protein kinase 0.0046 0.0073 0.0075
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0058 0.0189 0.0194
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0108 0.0678 0.0654
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0097 0.057 0.0585
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0201 0.1576 0.1617
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0081 0.0083
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Giardia lamblia Kinase, CK1 Casein kinase 0.006 0.0212 0.0181
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0058 0.0189 0.0149
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0186 0.1431 0.1431
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0147 0.1052 0.1052
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.006 0.0062
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0286 0.2394 0.2456
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0155 0.1126 0.1115
Loa Loa (eye worm) AGC/PKA protein kinase 0.0108 0.0678 0.0678
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0596 0.0611
Brugia malayi serine/threonine kinase 12 0.0145 0.1036 0.1036
Brugia malayi Protein kinase domain containing protein 0.0066 0.0268 0.0268
Schistosoma mansoni protein kinase C mu 0.0104 0.0638 0.0654
Echinococcus multilocularis tyrosine protein kinase Srms 0.0083 0.0429 0.0441
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0212 0.0174
Brugia malayi protein C17H12.11 0.007 0.0307 0.0307
Echinococcus granulosus activated cdc42 kinase 1 0.0218 0.1737 0.1782
Onchocerca volvulus 0.0091 0.0513 0.0487
Brugia malayi Protein kinase domain containing protein 0.0536 0.4808 0.4808
Echinococcus granulosus protein kinase C gamma type 0.0045 0.0065 0.0067
Onchocerca volvulus 0.0049 0.0106 0.0079
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0049 0.0106 0.0109
Brugia malayi serine/threonine-protein kinase PAK 7 0.0226 0.1818 0.1818
Echinococcus granulosus peroxidasin 0.0041 0.0031 0.0032
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0126 0.0851 0.0874
Echinococcus multilocularis roundabout 2 0.0045 0.0067 0.0069
Brugia malayi Stress-activated protein kinase jnk-1 0.0281 0.2346 0.2346
Loa Loa (eye worm) hypothetical protein 0.0041 0.0031 0.0031
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.057 0.0585
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0058 0.0192 0.0192
Loa Loa (eye worm) AGC/NDR protein kinase 0.0045 0.0065 0.0065
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0469 0.0439
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.1122 0.1122
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0083 0.0429 0.0441
Onchocerca volvulus 0.0049 0.0106 0.0079
Echinococcus granulosus dual specificity mitogen activated protein 0.0186 0.1431 0.1469
Loa Loa (eye worm) TK/ALK protein kinase 0.0616 0.5576 0.5576
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0504 0.4498 0.4616
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.057 0.0585
Echinococcus granulosus epidermal growth factor receptor 0.0096 0.0554 0.0569
Plasmodium falciparum serine/threonine protein kinase, putative 0.0145 0.1036 0.1029
Onchocerca volvulus 0.0054 0.0152 0.0125
Echinococcus multilocularis peroxidasin 0.0041 0.0031 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0027 0.0027
Echinococcus multilocularis tyrosine protein kinase Abl 0.0154 0.1122 0.1151
Trichomonas vaginalis STE family protein kinase 0.0186 0.1431 0.143
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0045 0.0067 0.0069
Entamoeba histolytica serine/threonine protein kinase, putative 0.0043 0.0044 0.0039
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.006 0.006
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0045 0.0068 0.0025
Echinococcus granulosus geminin 0.0164 0.1219 0.1251
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0097 0.057 0.0585
Entamoeba histolytica protein kinase, putative 0.0049 0.0103 0.01
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0027 0.0027
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0084 0.0443 0.0455
Brugia malayi hypothetical protein 0.0247 0.2019 0.2019
Trichomonas vaginalis CMGC family protein kinase 0.0155 0.1126 0.1115
Giardia lamblia Kinase, CAMK CAMKL 0.0052 0.0131 0.0097
Loa Loa (eye worm) hypothetical protein 0.0218 0.1737 0.1737
Brugia malayi Protein kinase domain containing protein 0.011 0.0697 0.0697
Echinococcus granulosus serine:threonine kinase SAD 1 0.0043 0.0044 0.0045
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0066 0.0268 0.0268
Schistosoma mansoni vam6/vps39 related 0.0058 0.0189 0.0194
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0113 0.0723 0.0723
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.006 0.0211 0.0216
Schistosoma mansoni cell adhesion molecule 0.0045 0.0067 0.0069
Echinococcus multilocularis Immunoglobulin 0.0088 0.0483 0.0496
Plasmodium falciparum protein kinase, putative 0.0045 0.0068 0.0033
Brugia malayi probable protein kinase 0.0143 0.1014 0.1014
Brugia malayi Protein kinase domain containing protein 0.0218 0.1737 0.1737
Loa Loa (eye worm) AGC/PKN protein kinase 0.0045 0.0065 0.0065
Schistosoma mansoni hypothetical protein 0.0164 0.1219 0.1251
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0088 0.0483 0.0496
Echinococcus granulosus mitogen activated protein kinase 11 0.0161 0.1186 0.1218
Schistosoma mansoni tyrosine kinase 0.0064 0.0247 0.0254
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0457 0.4047 1
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0211 0.0216
Echinococcus multilocularis roundabout 2 0.0133 0.0918 0.0943
Echinococcus granulosus cyclin dependent kinase 9 0.0077 0.038 0.039
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0073 0.003
Brugia malayi cyclin-dependent kinase 7 homolog 0.0114 0.0731 0.0731
Echinococcus granulosus hemicentin 1 0.0041 0.0027 0.0028
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0045 0.0065 0.0065
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.1047 0.9744 1
Giardia lamblia Kinase, STE STE20 0.0186 0.1431 0.1437
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.0149 0.107 0.107
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0617 0.5588 0.5715
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0087 0.047 0.047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0119 0.0119
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0153 0.1107 0.1136
Brugia malayi Protein kinase domain containing protein 0.0178 0.1346 0.1346
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0142 0.0999 0.1025
Loa Loa (eye worm) hypothetical protein 0.0092 0.0523 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0044 0.0045
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Giardia lamblia Kinase, AGC AKT 0.0113 0.0723 0.0707
Loa Loa (eye worm) hypothetical protein 0.0049 0.0106 0.0106
Plasmodium falciparum serine/threonine protein kinase KIN 0.0043 0.0044 0.0007
Brugia malayi casein kinase 1, delta 0.006 0.0212 0.0212
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.1047 0.9744 1
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0062 0.0233 0.0233
Loa Loa (eye worm) hypothetical protein 0.0129 0.0879 0.0879
Echinococcus multilocularis musashi 0.0054 0.0152 0.0156
Mycobacterium ulcerans hypothetical protein 0.0457 0.4047 1
Plasmodium vivax serine/threonine kinase-1, putative 0.0155 0.1126 0.1088
Schistosoma mansoni protein kinase 0.0187 0.1435 0.1473
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.1047 0.9744 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0112 0.0716 0.0729
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0087 0.047 0.047
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Onchocerca volvulus 0.007 0.0307 0.0281
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Schistosoma mansoni protein kinase 0.0187 0.1435 0.1473
Trypanosoma brucei protein kinase, putative 0.0126 0.085 0.0832
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.1019 0.1046
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1223 0.1255
Echinococcus granulosus protein kinase c iota type 0.0062 0.0233 0.0239
Schistosoma mansoni kinase 0.0068 0.0292 0.03
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0081 0.0081
Echinococcus granulosus activin receptor type 0.0464 0.4112 0.422
Trypanosoma cruzi cdc2-related kinase 1 0.0066 0.0268 0.0231
Echinococcus granulosus twitchin 0.013 0.089 0.0913
Plasmodium falciparum calcium-dependent protein kinase 1 0.006 0.0211 0.0179
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0145 0.1036 0.1058
Loa Loa (eye worm) AGC/PKA protein kinase 0.0108 0.0678 0.0678
Loa Loa (eye worm) hypothetical protein 0.0045 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0073 0.0337 0.0337
Brugia malayi Prion-like- 0.0041 0.0027 0.0027
Echinococcus granulosus contactin 0.0045 0.0067 0.0069
Onchocerca volvulus 0.0159 0.1163 0.1139
Schistosoma mansoni tyrosine kinase 0.0142 0.0999 0.1025
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0073 0.003
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0044 0.0045
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0161 0.1186 0.1178
Echinococcus multilocularis death associated protein kinase 1 0.0948 0.8789 0.9019
Brugia malayi protein kinase C II. 0.0062 0.0233 0.0233
Trichomonas vaginalis CMGC family protein kinase 0.0126 0.085 0.0832
Brugia malayi Protein kinase domain containing protein 0.0084 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0043 0.0044 0.0044
Entamoeba histolytica protein kinase , putative 0.0145 0.1036 0.1058
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0101 0.0611 0.0627
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0199 0.1557 0.1557
Loa Loa (eye worm) hypothetical protein 0.0159 0.1163 0.1163
Brugia malayi putative serine/threonine kinase SADA gamma 0.0043 0.0044 0.0044
Brugia malayi Protein kinase domain containing protein 0.0199 0.1557 0.1557
Trichomonas vaginalis CMGC family protein kinase 0.0126 0.085 0.0832
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0027 0.0027
Echinococcus multilocularis protein KINase family member (kin 25) 0.0101 0.0611 0.0627
Trypanosoma cruzi cdc2-related kinase 3 0.0066 0.0268 0.0231
Onchocerca volvulus 0.0126 0.085 0.0826
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.0149 0.107 0.1099
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0088 0.0483 0.0496
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0066 0.0268 0.0268
Loa Loa (eye worm) AUR protein kinase 0.0145 0.1036 0.1036
Brugia malayi latrophilin 2 splice variant baaae 0.0101 0.0603 0.0603
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0142 0.0999 0.1025
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0233 0.1882 0.1932
Entamoeba histolytica protein kinase, putative 0.0045 0.0065 0.0061
Schistosoma mansoni protein kinase 0.006 0.0212 0.0218
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.057 0.0585
Brugia malayi hypothetical protein 0.0049 0.0106 0.0106
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0145 0.1036 0.1058
Echinococcus multilocularis tyrosine kinase 0.0049 0.0106 0.0109
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.2451 0.2481
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0596 0.0611
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Echinococcus granulosus protein kinase 0.0085 0.0458 0.047
Loa Loa (eye worm) hypothetical protein 0.0555 0.499 0.499
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0167 0.1241 0.1241
Brugia malayi hypothetical protein 0.0058 0.0189 0.0189
Brugia malayi Furin-like cysteine rich region family protein 0.0096 0.0554 0.0554
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0219 0.018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0081 0.0083
Echinococcus granulosus casein kinase i 0.006 0.0212 0.0218
Loa Loa (eye worm) hypothetical protein 0.0088 0.0483 0.0483
Leishmania major protein kinase A catalytic subunit isoform 1 0.0108 0.0678 0.0654
Trypanosoma brucei casein kinase I, isoform 2 0.006 0.0212 0.0174
Loa Loa (eye worm) hypothetical protein 0.006 0.0211 0.0211
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.1047 0.9744 0.9744
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0644 0.0661
Plasmodium vivax glycogen synthase kinase 3, putative 0.0126 0.085 0.0804
Brugia malayi bone morphogenetic protein type 1 receptor 0.011 0.0697 0.0697
Entamoeba histolytica casein kinase, putative 0.006 0.0212 0.0212
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0058 0.0189 0.0194
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0097 0.057 0.0585
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0221 0.1764 0.1774
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0212 0.0174
Echinococcus multilocularis hemicentin 1 0.0041 0.0027 0.0028
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0108 0.0678 0.0661
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0058 0.0189 0.0194
Echinococcus granulosus protein kinase shaggy 0.0126 0.085 0.0873
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0187 0.1435 0.1473
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0067 0.0067
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0099 0.0587 0.0602
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2019 0.2072
Loa Loa (eye worm) hypothetical protein 0.0176 0.133 0.133
Echinococcus multilocularis lamin 0.0054 0.0152 0.0156
Schistosoma mansoni nephrin 0.0045 0.0067 0.0069
Onchocerca volvulus 0.0184 0.1406 0.1383
Schistosoma mansoni serine/threonine kinase 0.0045 0.0065 0.0067
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.1047 0.9744 1
Brugia malayi serine/threonine protein kinase 6 0.0145 0.1036 0.1036
Trypanosoma cruzi casein kinase, putative 0.006 0.0212 0.0174
Echinococcus granulosus tyrosine protein kinase Src42A 0.0056 0.0173 0.0178
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0083
Loa Loa (eye worm) TK protein kinase 0.0062 0.0229 0.0229
Echinococcus multilocularis epidermal growth factor receptor 0.0096 0.0554 0.0569
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0073 0.003
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.1047 0.9744 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0164 0.1212 0.1212
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.006 0.0211 0.0211
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0108 0.0678 0.0654
Loa Loa (eye worm) hypothetical protein 0.0119 0.078 0.078
Trichomonas vaginalis AGC family protein kinase 0.0108 0.0678 0.0654
Plasmodium falciparum calcium-dependent protein kinase 2 0.006 0.0211 0.0179
Loa Loa (eye worm) AUR protein kinase 0.0145 0.1036 0.1036
Echinococcus multilocularis aurora kinase A 0.0145 0.1036 0.1063
Onchocerca volvulus 0.0049 0.0106 0.0079
Loa Loa (eye worm) hypothetical protein 0.0159 0.1163 0.1163
Echinococcus granulosus dual specificity protein kinase clk2 0.0155 0.1126 0.1155
Echinococcus multilocularis mitogen activated protein kinase 14 0.0161 0.1186 0.1218
Leishmania major protein kinase A catalytic subunit 0.0108 0.0678 0.0654
Schistosoma mansoni lamin 0.0054 0.0152 0.0156
Leishmania major protein kinase, putative 0.0145 0.1036 0.1023
Trichomonas vaginalis AGC family protein kinase 0.0145 0.1036 0.1023
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.006 0.0212 0.0212
Echinococcus multilocularis 0.0138 0.0963 0.0988
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0208 0.1645 0.1688
Schistosoma mansoni hypothetical protein 0.0164 0.1219 0.1251
Loa Loa (eye worm) hypothetical protein 0.0073 0.0337 0.0337
Brugia malayi Immunoglobulin I-set domain containing protein 0.0489 0.4353 0.4353
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.1047 0.9744 1
Trypanosoma cruzi cdc2-related kinase 3 0.0066 0.0268 0.0231
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0199 0.1557 0.1557
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0088 0.0483 0.0496
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.006 0.0211 0.0172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.006 0.0062
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0141 0.0993 0.1019
Entamoeba histolytica protein kinase, putative 0.0049 0.0103 0.01
Loa Loa (eye worm) hypothetical protein 0.0101 0.0611 0.0611
Onchocerca volvulus 0.0095 0.0552 0.0527
Brugia malayi Calcitonin receptor-like protein seb-1 0.0147 0.1052 0.1052
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0052 0.0131 0.006
Echinococcus multilocularis tyrosine protein kinase shark 0.0049 0.0106 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0184 0.1406 0.1443
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0186 0.1431 0.143
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Echinococcus granulosus hypothetical protein 0.0138 0.0963 0.0988
Loa Loa (eye worm) hypothetical protein 0.0147 0.1052 0.1052
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0233 0.0239
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0219 0.0225
Echinococcus granulosus NDR protein kinase 0.0045 0.0065 0.0067
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0127 0.0857 0.0857
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0678 0.0696
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0233 0.1882 0.1932
Giardia lamblia Kinase, CMGC CDK 0.0066 0.0268 0.0239
Loa Loa (eye worm) hypothetical protein 0.0126 0.0851 0.0851
Echinococcus multilocularis cyclin dependent kinase 9 0.0077 0.038 0.039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0097 0.057 0.0585
Entamoeba histolytica protein kinase, putative 0.0045 0.0065 0.0061
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0067 0.0067
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0186 0.1431 0.143
Plasmodium falciparum calcium-dependent protein kinase 5 0.006 0.0211 0.0179
Brugia malayi hypothetical protein 0.0233 0.1882 0.1882
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0201 0.1576 0.1617
Brugia malayi Protein kinase domain containing protein 0.0049 0.0106 0.0106
Schistosoma mansoni tyrosine kinase 0.0203 0.1595 0.1637
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0221 0.1764 0.1764
Brugia malayi Protein kinase domain containing protein 0.0321 0.273 0.273
Onchocerca volvulus 0.0049 0.0106 0.0079
Entamoeba histolytica protein kinase, putative 0.006 0.0211 0.0211
Schistosoma mansoni vav2 0.0042 0.0038 0.0039
Schistosoma mansoni alpha-glucosidase 0.0142 0.1002 0.1028
Leishmania major protein kinase, putative 0.0155 0.1126 0.1115
Onchocerca volvulus Tyrosine kinase homolog 0.041 0.3594 0.3576
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0045 0.0067 0.0067
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.006 0.0211 0.0142
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0045 0.0065 0.0065
Loa Loa (eye worm) AGC/AKT protein kinase 0.0049 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0054 0.0152 0.0152
Plasmodium falciparum protein kinase 5 0.0066 0.0268 0.0239
Trichomonas vaginalis STE family protein kinase 0.0186 0.1431 0.143
Loa Loa (eye worm) TK protein kinase 0.0167 0.1243 0.1243
Echinococcus multilocularis casein kinase I alpha 0.006 0.0212 0.0218
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.1047 0.9744 1
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0056 0.0173 0.0178
Brugia malayi Immunoglobulin I-set domain containing protein 0.0045 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0065 0.0067
Trypanosoma brucei aurora B kinase 0.0145 0.1036 0.1023
Brugia malayi Protein kinase domain containing protein 0.0616 0.5578 0.5578
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.006 0.0062
Brugia malayi cyclin-dependent kinase 9 0.0068 0.0292 0.0292
Toxoplasma gondii AGC kinase 0.0108 0.0678 0.0654
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0219 0.0225
Schistosoma mansoni hypothetical protein 0.0058 0.0189 0.0194
Toxoplasma gondii aurora kinase 0.0145 0.1036 0.1023
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0519 0.0533
Echinococcus granulosus lamin 0.0054 0.0152 0.0156
Schistosoma mansoni septate junction protein 0.0041 0.0027 0.0028
Echinococcus multilocularis mitogen activated protein kinase 11 0.0161 0.1186 0.1218
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0027 0.0027
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0049 0.0106 0.0103
Brugia malayi Tyrosine-protein kinase abl-1 0.0146 0.1045 0.1045
Trichomonas vaginalis CK1 family protein kinase 0.006 0.0212 0.0174
Onchocerca volvulus 0.1074 1 1
Giardia lamblia Kinase, CMGC CDK 0.0066 0.0268 0.0239
Plasmodium vivax calcium-dependent protein kinase, putative 0.006 0.0211 0.0142
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0126 0.085 0.085
Loa Loa (eye worm) IKK protein kinase 0.1074 1 1
Leishmania major protein kinase A catalytic subunit isoform 2 0.0108 0.0678 0.0654
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Schistosoma mansoni cell adhesion molecule 0.0041 0.0027 0.0028
Echinococcus multilocularis insulin receptor 0.0178 0.1346 0.1382
Echinococcus granulosus tyrosine protein kinase shark 0.0049 0.0106 0.0109
Echinococcus granulosus fibroblast growth factor receptor 4 0.0142 0.0999 0.1025
Echinococcus granulosus lamin dm0 0.0054 0.0152 0.0156
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.0292 0.0294
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0097 0.057 0.0585
Echinococcus multilocularis lachesin 0.0041 0.0027 0.0028
Loa Loa (eye worm) AUR protein kinase 0.0145 0.1036 0.1036
Brugia malayi Immunoglobulin I-set domain containing protein 0.0167 0.1243 0.1243
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.1047 0.9744 1
Echinococcus multilocularis transfer RNA-Thr 0.0218 0.1737 0.1782
Brugia malayi Protein kinase domain containing protein 0.0087 0.047 0.047
Echinococcus granulosus roundabout 2 0.0133 0.0918 0.0943
Schistosoma mansoni protein kinase 0.0186 0.1431 0.1469
Entamoeba histolytica protein kinase, putative 0.0145 0.1036 0.1058
Echinococcus multilocularis calcium dependent protein kinase 0.0043 0.0048 0.0049
Mycobacterium ulcerans hypothetical protein 0.0325 0.2769 0.6662
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.006 0.0211 0.0211
Echinococcus granulosus GPCR family 2 0.0047 0.0081 0.0083
Echinococcus granulosus casein kinase I alpha 0.006 0.0212 0.0218
Loa Loa (eye worm) hypothetical protein 0.019 0.1463 0.1463
Leishmania major mitochondrial DNA polymerase beta 0.0617 0.5588 0.5715
Schistosoma mansoni protein kinase 0.011 0.0697 0.0716
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0108 0.0678 0.0625
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0067 0.0069
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0045 0.0065 0.0065
Echinococcus multilocularis G protein coupled receptor kinase 6 0.0149 0.107 0.1099
Onchocerca volvulus 0.0049 0.0106 0.0079
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0097 0.057 0.0585
Loa Loa (eye worm) TK/INSR protein kinase 0.0178 0.1346 0.1346
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.024 0.024
Brugia malayi jmjC domain containing protein 0.01 0.0596 0.0596
Toxoplasma gondii casein kinase I 0.006 0.0212 0.0174
Echinococcus granulosus Protein kinase C brain isozyme 0.0062 0.0233 0.0239
Echinococcus multilocularis cyclin dependent kinase 7 0.0105 0.0644 0.0661
Schistosoma mansoni tyrosine kinase 0.0096 0.0554 0.0569
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0039 0.004
Loa Loa (eye worm) hypothetical protein 0.0104 0.0635 0.0635
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0108 0.0678 0.0654
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.006 0.0211 0.0172
Brugia malayi Protein kinase domain containing protein 0.0049 0.0106 0.0106
Brugia malayi Protein kinase domain containing protein 0.0045 0.0065 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.1882 0.1932
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1223 0.1223
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0161 0.1186 0.1178
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.011 0.0693 0.0711
Schistosoma mansoni serine/threonine protein kinase 0.0164 0.1212 0.1244
Echinococcus granulosus tyrosine protein kinase HCK 0.0062 0.0229 0.0235
Echinococcus multilocularis tyrosine protein kinase otk 0.0041 0.0027 0.0028
Echinococcus granulosus epidermal growth factor receptor 0.0096 0.0554 0.0569
Loa Loa (eye worm) hypothetical protein 0.0101 0.0603 0.0603
Echinococcus multilocularis cyclin dependent kinase 9 0.0068 0.0292 0.03
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0073 0.0075
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0155 0.1126 0.1126
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0027 0.0027
Echinococcus granulosus c src tyrosine kinase 0.0064 0.0247 0.0254
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0091 0.0515 0.0529
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0141 0.0993 0.0993
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0155 0.1126 0.1115
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0084 0.0442 0.0442
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.006 0.0062
Echinococcus granulosus tyrosine protein kinase Blk 0.0083 0.0429 0.0441
Echinococcus multilocularis neuroglian 0.0113 0.0727 0.0746
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Echinococcus granulosus insulin receptor 0.0178 0.1346 0.1382
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0083
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0084 0.0442 0.0453
Echinococcus granulosus rho-associated protein kinase 1 0.0184 0.1406 0.1443
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0145 0.1036 0.1063
Schistosoma mansoni roundabout 0.0041 0.0027 0.0028
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0199 0.1557 0.1557
Brugia malayi Peroxidasin 0.0041 0.0031 0.0031
Brugia malayi Protein kinase domain containing protein 0.0049 0.0106 0.0106
Schistosoma mansoni rap gtpase-activating protein 0.0058 0.0189 0.0194
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0041 0.0027 0.0028
Schistosoma mansoni tyrosine kinase 0.0049 0.0106 0.0109
Trypanosoma cruzi casein kinase, putative 0.006 0.0212 0.0174
Echinococcus granulosus roundabout 2 0.0045 0.0067 0.0069
Echinococcus multilocularis serine threonine protein kinase 0.0045 0.0065 0.0067
Schistosoma mansoni protein kinase 0.0143 0.1014 0.1041
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0126 0.085 0.0873
Schistosoma mansoni tyrosine kinase 0.0097 0.057 0.0585
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0149 0.0149
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0045 0.0067 0.0069
Giardia lamblia Kinase, CMGC GSK 0.0126 0.085 0.0838
Echinococcus granulosus protein tyrosine kinase 0.0317 0.2697 0.2768
Entamoeba histolytica cell division protein kinase 2, putative 0.0075 0.0355 0.0359
Schistosoma mansoni hypothetical protein 0.005 0.0119 0.0122
Echinococcus multilocularis raf serine:threonine protein kinase 0.0046 0.0073 0.0075
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0142 0.0999 0.1025
Loa Loa (eye worm) hypothetical protein 0.0138 0.0963 0.0963
Schistosoma mansoni nephrin 0.0118 0.0767 0.0787
Echinococcus multilocularis epidermal growth factor receptor 0.0096 0.0554 0.0569
Echinococcus granulosus intermediate filament protein 0.0054 0.0152 0.0156
Loa Loa (eye worm) TK/FER protein kinase 0.0049 0.0106 0.0106
Echinococcus multilocularis dual specificity protein kinase clk2 0.0155 0.1126 0.1155
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0045 0.0068 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0145 0.1036 0.1063
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0104 0.0638 0.0638
Echinococcus multilocularis 0.0085 0.0458 0.047
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.006 0.0211 0.0142
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0066 0.0268 0.0231
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0268 0.0231
Echinococcus granulosus casein kinase I alpha 0.006 0.0212 0.0218
Echinococcus granulosus serine:threonine protein kinase N2 0.0045 0.0065 0.0067
Echinococcus granulosus defective proboscis extension response 0.0088 0.0483 0.0496
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0489 0.4353 0.4353
Brugia malayi Protein kinase domain containing protein 0.0049 0.0103 0.0103
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0081 0.0081
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0064 0.0247 0.0254
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0108 0.0678 0.0654
Loa Loa (eye worm) hypothetical protein 0.0092 0.0523 0.0523
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0212 0.0218
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1223 0.1255
Loa Loa (eye worm) hypothetical protein 0.0058 0.0189 0.0189
Leishmania major protein kinase, putative 0.0045 0.0068 0.0025
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0091 0.0515 0.0529
Echinococcus granulosus plexin a4 0.0038 0.0003 0.0003
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Loa Loa (eye worm) hypothetical protein 0.0041 0.0027 0.0027
Onchocerca volvulus 0.006 0.0212 0.0186
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.006 0.0211 0.0216
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0054 0.0149 0.0153
Echinococcus granulosus neuroglian 0.0113 0.0727 0.0746
Entamoeba histolytica protein kinase, putative 0.0062 0.0229 0.0229
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.1047 0.9744 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0219 0.0225
Echinococcus multilocularis geminin 0.0164 0.1219 0.1251
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.006 0.0212 0.0212
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0058 0.0189 0.0149
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0155 0.1133 0.1162
Brugia malayi Hr1 repeat family protein 0.0045 0.0065 0.0065
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.006 0.0211 0.0172
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0155 0.1126 0.1115
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0108 0.0678 0.0696
Echinococcus multilocularis neuroglian 0.0045 0.0067 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0141 0.0993 0.1019
Echinococcus multilocularis casein kinase I alpha 0.006 0.0212 0.0218
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0075 0.0351 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0233 0.0239
Echinococcus granulosus aurora kinase A 0.0145 0.1036 0.1063
Echinococcus granulosus mitogen activated protein kinase 14 0.0161 0.1186 0.1218
Brugia malayi SH2 domain containing protein 0.0049 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0047 0.0081 0.0081
Trypanosoma brucei rac serine-threonine kinase, putative 0.0049 0.0103 0.0061
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0219 0.0225
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0043 0.0044 0.0045
Brugia malayi SH2 domain containing protein 0.0049 0.0106 0.0106
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0108 0.0678 0.0654
Echinococcus granulosus tyrosine protein kinase otk 0.0041 0.0027 0.0028
Onchocerca volvulus 0.005 0.0119 0.0092
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0117 0.076 0.0739
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.006 0.0211 0.0142
Brugia malayi C1-like domain containing protein 0.0104 0.0638 0.0638
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0211 0.0216
Loa Loa (eye worm) hypothetical protein 0.007 0.0307 0.0307
Schistosoma mansoni tyrosine kinase 0.0067 0.0281 0.0288
Echinococcus granulosus tyrosine protein kinase Srms 0.0049 0.0106 0.0109
Schistosoma mansoni titin 0.0041 0.0027 0.0028
Echinococcus multilocularis casein kinase I delta 0.006 0.0212 0.0218
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0108 0.0678 0.0654
Trichomonas vaginalis AGC family protein kinase 0.0045 0.0065 0.0022
Giardia lamblia Aurora kinase 0.0145 0.1036 0.1029
Entamoeba histolytica protein kinase domain containing protein 0.0126 0.085 0.0867
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0678 0.0696
Echinococcus multilocularis casein kinase i 0.006 0.0212 0.0218
Echinococcus granulosus tyrosine protein kinase Fyn 0.0097 0.057 0.0585
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.006 0.0211 0.0216
Brugia malayi Immunoglobulin I-set domain containing protein 0.0046 0.0078 0.0078
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0058 0.0189 0.0149
Schistosoma mansoni protein kinase 0.0085 0.0458 0.047
Plasmodium falciparum calcium-dependent protein kinase 4 0.006 0.0211 0.0179
Loa Loa (eye worm) hypothetical protein 0.0203 0.1596 0.1596
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0104 0.0635 0.0651
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0075 0.0351 0.0361
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0041 0.0027 0.0027
Brugia malayi Fibronectin type III domain containing protein 0.0092 0.0523 0.0523
Echinococcus multilocularis serine:threonine protein kinase 38 0.0045 0.0065 0.0067
Schistosoma mansoni tyrosine kinase 0.0067 0.0281 0.0288
Onchocerca volvulus Huntingtin homolog 0.0119 0.0778 0.0753
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0469 0.0439
Toxoplasma gondii AGC kinase 0.0108 0.0678 0.0654
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0108 0.0678 0.0654
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0216 0.1718 0.1763
Loa Loa (eye worm) hypothetical protein 0.0129 0.0879 0.0879
Echinococcus multilocularis protein tyrosine kinase 0.0317 0.2697 0.2768
Trichomonas vaginalis CMGC family protein kinase 0.0066 0.0268 0.0231
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0068 0.0292 0.0292
Schistosoma mansoni atypical protein kinase C 0.0062 0.0233 0.0239
Schistosoma mansoni protein kinase 0.0045 0.0068 0.007
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0155 0.1126 0.1115
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0045 0.0065 0.0067
Loa Loa (eye worm) hypothetical protein 0.007 0.0307 0.0307
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1223 0.1255
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0186 0.1431 0.143
Schistosoma mansoni lamin 0.0054 0.0152 0.0156
Schistosoma mansoni tyrosine kinase 0.0069 0.0301 0.0309
Onchocerca volvulus 0.0049 0.0106 0.0079
Giardia lamblia Kinase, CAMK CAMKL 0.0052 0.0131 0.0097
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0199 0.1557 0.1598
Plasmodium falciparum glycogen synthase kinase 3 0.0126 0.085 0.0838
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0469 0.0439
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0066 0.0268 0.0268
Echinococcus multilocularis plexin a4 0.0038 0.0003 0.0003
Trichomonas vaginalis AGC family protein kinase 0.0049 0.0103 0.0061
Trypanosoma cruzi casein kinase, putative 0.006 0.0212 0.0174
Echinococcus multilocularis casein kinase I delta 0.006 0.0212 0.0218
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0108 0.0678 0.0654
Echinococcus granulosus titin 0.0046 0.0078 0.008
Echinococcus multilocularis mitogen activated protein kinase 11 0.0161 0.1186 0.1218
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0045 0.0067 0.0069
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0027 0.0027
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0045 0.0068 0.007
Onchocerca volvulus 0.0087 0.0475 0.0449
Brugia malayi Immunoglobulin I-set domain containing protein 0.0058 0.0192 0.0192
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0108 0.0678 0.0678
Echinococcus multilocularis lamin dm0 0.0054 0.0152 0.0156
Trypanosoma cruzi aurora B kinase, putative 0.0145 0.1036 0.1023
Entamoeba histolytica casein kinase 1, putative 0.006 0.0212 0.0212
Plasmodium falciparum protein serine/threonine kinase-1 0.0155 0.1126 0.1122
Brugia malayi Protein kinase domain containing protein 0.0167 0.1241 0.1241
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0126 0.085 0.0873
Echinococcus granulosus casein kinase I delta 0.006 0.0212 0.0218
Echinococcus granulosus protein kinase c epsilon type 0.0062 0.0233 0.0239
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0045 0.0067 0.0069
Loa Loa (eye worm) hypothetical protein 0.0088 0.0483 0.0483
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.1047 0.9744 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.006 0.0062
Onchocerca volvulus 0.0043 0.0049 0.0022
Schistosoma mansoni hypothetical protein 0.0047 0.0081 0.0083
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0092 0.0519 0.0533
Schistosoma mansoni cell adhesion molecule 0.0045 0.0067 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0045 0.0065 0.0067
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0617 0.5588 0.5715
Loa Loa (eye worm) hypothetical protein 0.0204 0.1602 0.1602
Schistosoma mansoni tyrosine kinase 0.0317 0.2697 0.2768
Schistosoma mansoni retinoic acid receptor RXR 0.0122 0.0814 0.0836
Plasmodium vivax casein kinase 1, putative 0.006 0.0212 0.0144
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0199 0.1557 0.1534
Echinococcus granulosus tyrosine protein kinase Src42A 0.0097 0.057 0.0585
Schistosoma mansoni intermediate filament proteins 0.0054 0.0152 0.0156
Brugia malayi p70 ribosomal S6 kinase beta 0.0045 0.0065 0.0065
Trypanosoma brucei protein kinase, putative 0.0045 0.0068 0.0025

Activities

Activity type Activity value Assay description Source Reference
Inhibition frequency index (IFI) (functional) = 0.72 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = -3 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 16 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 25 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 92 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 6.05 XC50 determination of P. falciparum 3D7 growth GSK. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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