Detailed information for compound 595462

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.434 | Formula: C23H25Cl2N3O3S
  • H donors: 1 H acceptors: 3 LogP: 5.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(OCCCN2CCC(C2)NS(=O)(=O)c2ccc(c(c2)Cl)Cl)c2c(n1)cccc2
  • InChi: 1S/C23H25Cl2N3O3S/c1-16-13-23(19-5-2-3-6-22(19)26-16)31-12-4-10-28-11-9-17(15-28)27-32(29,30)18-7-8-20(24)21(25)14-18/h2-3,5-8,13-14,17,27H,4,9-12,15H2,1H3
  • InChiKey: WKPBQYTUNPPPTR-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.014 0.014
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0099 0.1045
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.014 0.048
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0211 0.0771
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0407 0.1577
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.107 0.4289
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0172 0.0615
Echinococcus granulosus expressed protein 0.0012 0.0022 0.0029
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0161 0.1749
Schistosoma mansoni DNA polymerase eta 0.006 0.0534 0.0705
Echinococcus multilocularis phosphoglycerate kinase 1 0.0086 0.0814 0.0814
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0032 0.0039
Schistosoma mansoni jumonji domain containing protein 0.0154 0.1535 0.2026
Loa Loa (eye worm) hypothetical protein 0.0039 0.0308 0.0969
Brugia malayi hypothetical protein 0.0048 0.0407 0.1401
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0119 0.1292
Echinococcus granulosus dna polymerase eta 0.006 0.0534 0.0705
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0407 0.0537
Echinococcus granulosus bloom syndrome protein 0.0024 0.0153 0.0201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0223 0.0294
Leishmania major hypothetical protein, conserved 0.0015 0.0058 0.0081
Schistosoma mansoni hypothetical protein 0.0719 0.758 1
Brugia malayi polk-prov protein 0.0038 0.0294 0.1012
Brugia malayi jmjC domain containing protein 0.0019 0.0096 0.0332
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.014 0.1121
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.02 0.2116
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0923 0.1217
Schistosoma mansoni chromobox protein 0.0023 0.014 0.0184
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0041 0.033 0.0698
Echinococcus granulosus Chromobox protein 3 0.0023 0.014 0.0184
Echinococcus multilocularis Regulator of G protein signaling 20 0.0048 0.0407 0.0407
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0211 0.0772
Loa Loa (eye worm) hypothetical protein 0.0079 0.0738 0.2323
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0211 0.0771
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0104 0.0153
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0022 0.0029
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.1005 0.3457
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0178 0.0637
Schistosoma mansoni hypothetical protein 0.0059 0.0524 0.0691
Schistosoma mansoni ran 0.0021 0.0119 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.2908 0.3836
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.02 0.0302
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0211 0.2588
Loa Loa (eye worm) heterochromatin protein 1 0.0141 0.1401 0.4409
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.002 0.0107 0.0805
Echinococcus granulosus importin subunit beta 1 0.0029 0.02 0.0265
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0204 0.0269
Schistosoma mansoni hypothetical protein 0.0048 0.0408 0.0538
Plasmodium vivax SET domain protein, putative 0.0031 0.0223 0.2681
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0165 0.1788
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0022 0.0029
Brugia malayi Bromodomain containing protein 0.0078 0.0723 0.2485
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.0407 0.0537
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0231 0.035
Trichomonas vaginalis ran, putative 0.0021 0.0119 0.0397
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0211 0.2223
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0161 0.0213
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0165 0.0247
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.014 0.0481
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0546 0.084
Schistosoma mansoni hypothetical protein 0.0307 0.3179 0.4193
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0034 0.0258 0.0341
Chlamydia trachomatis phosphoglycerate kinase 0.0086 0.0814 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.107 0.1655
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0407 0.1577
Toxoplasma gondii hypothetical protein 0.0086 0.0809 0.8537
Schistosoma mansoni zinc finger protein 0.0015 0.0058 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0304
Schistosoma mansoni hypothetical protein 0.0104 0.1005 0.1326
Echinococcus granulosus regulator of G protein signaling 3 0.0048 0.0407 0.0537
Loa Loa (eye worm) hypothetical protein 0.0025 0.0158 0.0497
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0142 0.0492
Schistosoma mansoni cpg binding protein 0.0063 0.0568 0.075
Loa Loa (eye worm) hypothetical protein 0.0072 0.0658 0.2072
Trichomonas vaginalis dullard protein, putative 0.0025 0.0161 0.057
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.3045
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0155 0.0204
Brugia malayi Regulator of G protein signaling domain containing protein 0.0048 0.0407 0.1401
Trichomonas vaginalis set domain proteins, putative 0.024 0.2464 1
Schistosoma mansoni zinc finger protein 0.0021 0.0123 0.0162
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0546 0.084
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0161 0.0242
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.107 0.3192
Loa Loa (eye worm) hypothetical protein 0.0104 0.1005 0.3162
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.3045
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0066 0.07
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.033 0.0504
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0165 0.1741
Trypanosoma brucei phosphoglycerate kinase 0.0086 0.0814 0.1257
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0407 0.0537
Schistosoma mansoni ran 0.0021 0.0119 0.0157
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0142 0.0492
Leishmania major mitochondrial DNA polymerase beta 0.0612 0.6433 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.007
Giardia lamblia DNA damage repair protein 0.0011 0.0006 0.0067
Brugia malayi hypothetical protein 0.0042 0.0341 0.1173
Echinococcus multilocularis peregrin 0.0061 0.055 0.055
Schistosoma mansoni phosphoglycerate kinase 0.0086 0.0814 0.1074
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0022 0.0029
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2153 0.6773
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0408 0.1402
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0161 0.0161
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.3045
Echinococcus granulosus beta-adrenergic receptor kinase 0.0297 0.3071 0.4052
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.3179 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0523 0.5521
Mycobacterium ulcerans phosphoglycerate kinase 0.0086 0.0814 0.2425
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0524 0.641
Trichomonas vaginalis dullard protein, putative 0.0025 0.0161 0.057
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0012 0.0022 0.0022
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.2988 0.464
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0161 0.057
Toxoplasma gondii hypothetical protein 0.0099 0.0948 1
Brugia malayi 6-phosphofructokinase 0.011 0.107 0.3679
Brugia malayi hypothetical protein 0.0012 0.0022 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.2908 0.3836
Echinococcus multilocularis chromobox protein 1 0.0141 0.1401 0.1401
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0165 0.0218
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0096 0.0304
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0189 0.0249
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0096 0.0127
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0012 0.0022 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Trichomonas vaginalis chromobox protein, putative 0.0141 0.1401 0.5648
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0491 0.1922
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0099 0.0144
Giardia lamblia Phosphoglycerate kinase 0.0086 0.0814 0.8821
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Echinococcus multilocularis regulator of G protein signaling 7 0.0048 0.0407 0.0407
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0034 0.0258 0.0258
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0211 0.0772
Brugia malayi PHD-finger family protein 0.0023 0.0138 0.0473
Brugia malayi AF-10 protein 0.0019 0.0099 0.0341
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0153 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0216 0.0327
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0812 0.1254
Echinococcus multilocularis dna polymerase eta 0.006 0.0534 0.0534
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0657 0.0657
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0012 0.0022 0.0076
Plasmodium falciparum importin beta, putative 0.0029 0.02 0.2463
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0153 0.0525
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.0534 0.0822
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.2908 0.9147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0812 0.1254
Loa Loa (eye worm) histone methyltransferase 0.001 0.0001 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0211 0.0771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.2908 0.3836
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0048 0.0407 0.0537
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0032 0.0038
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0178 0.0235
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0032 0.0039
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0923 0.8599
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0034 0.0258 0.0341
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0119 0.0119
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0104 0.0153
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0524 0.0524
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0104 0.0138
Brugia malayi Disco-interacting protein 2 homolog 0.0039 0.031 0.1065
Trichomonas vaginalis chromobox protein, putative 0.0141 0.1401 0.5648
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0923 0.1217
Schistosoma mansoni hypothetical protein 0.0025 0.0158 0.0209
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0161 0.1921
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0155 0.0155
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0032 0.0089
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0048 0.0407 0.1577
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0803 0.3196
Schistosoma mansoni kinase 0.0049 0.042 0.0554
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0165 0.1966
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.3071 0.4052
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0524 0.553
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.107 0.3365
Leishmania major ATP-dependent phosphofructokinase 0.011 0.107 0.1655
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0568 0.1788
Echinococcus granulosus Chromo domain 0.0023 0.014 0.0184
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0017 0.0078 0.0819
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0119 0.041
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0086 0.0814 0.2195
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Loa Loa (eye worm) hypothetical protein 0.0045 0.0372 0.1171
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0408 0.1282
Loa Loa (eye worm) hypothetical protein 0.0122 0.1201 0.3779
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0119 0.0176
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0211 0.1102
Trichomonas vaginalis hypothetical protein 0.0023 0.014 0.0481
Echinococcus multilocularis regulator of G protein signaling 3 0.0048 0.0407 0.0407
Echinococcus multilocularis expressed protein 0.0407 0.4241 0.4241
Onchocerca volvulus 0.0023 0.014 0.0481
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0142 0.0212
Schistosoma mansoni hypothetical protein 0.0048 0.0408 0.0538
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0289 0.2988 0.464
Schistosoma mansoni chromobox protein 0.0023 0.014 0.0184
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0048 0.0407 0.0537
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0096 0.0127
Brugia malayi chromobox protein homolog 3 0.0079 0.0738 0.254
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.1196 0.3764
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0099 0.1045
Entamoeba histolytica hypothetical protein 0.0023 0.014 0.1121
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0096 0.0127
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.014 0.0184
Echinococcus granulosus peregrin 0.0061 0.055 0.0725
Brugia malayi Regulator of G protein signaling domain containing protein 0.0048 0.0407 0.1401
Echinococcus granulosus G protein coupled receptor kinase 1 0.0249 0.2557 0.3373
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0178 0.0561
Echinococcus granulosus expressed protein 0.0407 0.4241 0.5595
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0161 0.057
Trichomonas vaginalis chromobox protein, putative 0.0023 0.014 0.0481
Entamoeba histolytica phosphofructokinase, putative 0.011 0.107 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0407 0.0537
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0923 0.2903
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0557 0.0557
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0161 0.0213
Echinococcus multilocularis chromobox protein 1 0.0141 0.1401 0.1401
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.107 0.107
Trypanosoma brucei polo-like protein kinase 0.0096 0.0923 0.1426
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.014 0.1474
Giardia lamblia PHD finger protein 15 0.0059 0.0524 0.5678
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0695 0.0917
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.014 0.0481
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0211 0.0771
Brugia malayi 6-phosphofructokinase 0.011 0.107 0.3679
Leishmania major phosphoglycerate kinase B, cytosolic 0.0086 0.0814 0.1257
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0135 0.0178
Echinococcus multilocularis snurportin 1 0.0307 0.3179 0.3179
Plasmodium falciparum phd finger protein, putative 0.0059 0.0524 0.6437
Loa Loa (eye worm) hypothetical protein 0.0041 0.0334 0.105
Leishmania major hypothetical protein, conserved 0.0019 0.0096 0.014
Schistosoma mansoni 6-phosphofructokinase 0.011 0.107 0.1411
Onchocerca volvulus 0.0054 0.047 0.1832
Schistosoma mansoni GTP-binding protein alpha subunit 0.0012 0.0022 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.0408 0.1282
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0408 0.1402
Plasmodium falciparum phosphoglycerate kinase 0.0086 0.0814 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.014 0.0184
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0161 0.0213
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0012 0.0022 0.007
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0012 0.0022 0.007
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0211 0.0772
Entamoeba histolytica phosphofructokinase, putative 0.011 0.107 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0096 0.0096
Echinococcus granulosus chromobox protein 1 0.0141 0.1401 0.1849
Plasmodium falciparum heterochromatin protein 1 0.0023 0.014 0.1715
Mycobacterium ulcerans hypothetical protein 0.0322 0.3338 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0068 0.0771
Giardia lamblia Kinase, PLK 0.0096 0.0923 1
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0524 0.1649
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.107 0.2986
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0165 0.0218
Schistosoma mansoni chromobox protein 0.0141 0.1401 0.1849
Entamoeba histolytica hypothetical protein 0.0023 0.014 0.1121
Plasmodium vivax hypothetical protein, conserved 0.0023 0.014 0.1652
Loa Loa (eye worm) phosphofructokinase 0.011 0.107 0.3365
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0216 0.0327
Schistosoma mansoni hypothetical protein 0.0042 0.0341 0.045
Loa Loa (eye worm) hypothetical protein 0.006 0.0534 0.1681
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0165 0.0247
Trypanosoma brucei unspecified product 0.0024 0.0145 0.0216
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.0546 0.2146
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0738 0.2933
Plasmodium vivax JmjC domain containing protein 0.0019 0.0096 0.1118
Leishmania major importin beta-1 subunit, putative 0.0023 0.0142 0.0212
Loa Loa (eye worm) hypothetical protein 0.0025 0.0161 0.0508
Brugia malayi PXA domain containing protein 0.0048 0.0407 0.1401
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0161 0.0213
Schistosoma mansoni ap endonuclease 0.002 0.0104 0.0138
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0812 0.1254
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0771 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0211 0.0772
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Brugia malayi CXXC zinc finger family protein 0.0063 0.0568 0.1955
Loa Loa (eye worm) PXA domain-containing protein 0.0048 0.0407 0.1282
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0012 0.0022 0.0029
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.0546 0.2146
Trypanosoma brucei unspecified product 0.0024 0.0145 0.0216
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0104 0.0104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0105 0.1013 0.1567
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.002 0.0107 0.0156
Entamoeba histolytica phosphofructokinase, putative 0.011 0.107 1
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0211 0.2531
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0096 0.0127
Brugia malayi jmjC domain containing protein 0.0019 0.0096 0.0332
Entamoeba histolytica hypothetical protein 0.0023 0.0142 0.1146
Leishmania major modification methylase-like protein 0.002 0.0107 0.0156
Echinococcus granulosus chromobox protein 1 0.0141 0.1401 0.1849
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.007
Loa Loa (eye worm) RecQ helicase 0.0024 0.0153 0.048
Echinococcus granulosus 6 phosphofructokinase 0.011 0.107 0.1411
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0193 0.196 0.196
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0086 0.0814 0.3243
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.0534 0.0822
Plasmodium vivax importin-beta 2, putative 0.0029 0.02 0.2405
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.014 0.0184
Brugia malayi regulator of G-protein signaling egl-10 0.0048 0.0407 0.1401
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Echinococcus multilocularis dna polymerase kappa 0.0061 0.0546 0.0546
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0104 0.0328
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0153 0.0534
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0223 0.2351
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0568 0.075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0001 0.0002
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0282 0.0429
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.107 1
Brugia malayi G-protein alpha subunit 0.0012 0.0022 0.0076
Brugia malayi PHD-finger family protein 0.0059 0.0524 0.1802
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0407 0.1577
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.007
Schistosoma mansoni hypothetical protein 0.0019 0.0099 0.0131
Brugia malayi Heterochromatin protein 1 0.0141 0.1401 0.482
Trichomonas vaginalis chromobox protein, putative 0.0023 0.014 0.0481
Brugia malayi jmjC domain containing protein 0.0193 0.196 0.6743
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.0534 0.1837
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.2908 0.2908
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0546 0.084
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0407 0.0537
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0155 0.0204
Echinococcus multilocularis regulator of G protein signaling 0.0048 0.0407 0.0407
Schistosoma mansoni hypothetical protein 0.0023 0.014 0.0184
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0012 0.0022 0.0029
Entamoeba histolytica hypothetical protein 0.0048 0.0407 0.3677
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.107 0.4289
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0923 0.0923
Trypanosoma brucei phosphoglycerate kinase, putative 0.0032 0.0231 0.035
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0408 0.0408
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0524 0.0691
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0223 0.0223
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0161 0.1921
Entamoeba histolytica phosphoglycerate kinase, putative 0.0086 0.0814 0.756
Brugia malayi PXA domain containing protein 0.0048 0.0407 0.1401
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0104 0.0153
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0048 0.0407 0.0537
Echinococcus multilocularis expressed protein 0.0012 0.0022 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0341 0.0341
Schistosoma mansoni z-protein (S1r protein) 0.0048 0.0407 0.0537
Leishmania major DNA polymerase eta, putative 0.006 0.0534 0.0822
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0022 0.0029
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0178 0.0235
Trichomonas vaginalis chaperonin, putative 0.0025 0.0165 0.0585
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0211 0.1799
Echinococcus granulosus axis inhibition protein axin 0.0048 0.0407 0.0537
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0077 0.0102
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0012 0.0022 0.0076
Plasmodium vivax phosphoglycerate kinase, putative 0.0086 0.0814 1
Leishmania major GTP-binding protein, putative 0.0021 0.0119 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0407 0.1577
Trypanosoma cruzi ISWI complex protein 0.0015 0.0058 0.0081
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.152 0.5228
Loa Loa (eye worm) hypothetical protein 0.0029 0.02 0.0631
Entamoeba histolytica hypothetical protein 0.0048 0.0407 0.3677
Echinococcus multilocularis axis inhibition protein axin 0.0048 0.0407 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Brugia malayi Valyl-tRNA synthetase 0.0023 0.014 0.048
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0096 0.1018
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0165 0.0567
Entamoeba histolytica deoxycytidyl transferase, putative 0.0034 0.0258 0.2255
Brugia malayi Bromodomain containing protein 0.0039 0.0307 0.1057
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0161 0.0555
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0096 0.0096
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.0695 0.2188
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0121 0.1487
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0282 0.2976
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.014 0.1121
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.014 0.0184
Toxoplasma gondii exonuclease III APE 0.002 0.0104 0.11
Leishmania major hypothetical protein, conserved 0.0025 0.0161 0.0242
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0249 0.2557 0.2557
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0096 0.0304
Schistosoma mansoni DNA polymerase IV / kappa 0.0011 0.0006 0.0008
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0211 0.0771
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0211 0.0772
Plasmodium vivax hypothetical protein, conserved 0.0023 0.014 0.1652
Trichomonas vaginalis chromobox protein, putative 0.0085 0.0803 0.3196
Leishmania major DNA polymerase eta, putative 0.0036 0.0282 0.0429
Brugia malayi Pre-SET motif family protein 0.0031 0.0223 0.0766
Brugia malayi PHD-finger family protein 0.0027 0.018 0.062
Toxoplasma gondii DNA methyltransferase 2, putative 0.002 0.0107 0.1125
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0227 0.0781
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0119 0.0157
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.107 1
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0076
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0104 0.0294
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0407 0.0537
Leishmania major phosphoglycerate kinase C, glycosomal 0.0086 0.0814 0.1257
Brugia malayi regulator of G-protein signaling rgs-7 0.0048 0.0407 0.1401
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0161 0.1703
Loa Loa (eye worm) hypothetical protein 0.0101 0.0975 0.3068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0322 0.3338 1
Schistosoma mansoni phosphoglycerate kinase 0.0086 0.0814 0.1074
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0096 0.0127
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0193 0.196 0.2586
Echinococcus multilocularis DNA methyltransferase 2, putative 0.002 0.0107 0.0107
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0034 0.0258 0.0813
Leishmania major DNA polymerase kappa, putative 0.0041 0.033 0.0504
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0289 0.2988 0.464
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0524 0.553
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0165 0.0165
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0341 0.045
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0153 0.0153
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0001 0.0001
Brugia malayi Phosphoglycerate kinase 0.0086 0.0814 0.28
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0418 0.0552
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0086 0.0814 0.1257
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0165 0.0567
Giardia lamblia DINP protein human, muc B family 0.0041 0.033 0.3574
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.0695 0.0917
Onchocerca volvulus 0.0062 0.0556 0.2185
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Schistosoma mansoni cpg binding protein 0.0067 0.0607 0.0801
Entamoeba histolytica hypothetical protein 0.0023 0.014 0.1121
Brugia malayi Bromodomain containing protein 0.0061 0.055 0.189
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.014 0.1474
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0211 0.2223
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0178 0.0178
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0048 0.0407 0.0407
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0165 0.0585
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0086 0.0814 0.8592
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0012 0.0022 0.0029
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0076
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0142 0.0492
Loa Loa (eye worm) helicase 0.0023 0.014 0.0439
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0161 0.057
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0104 0.0359
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0104 0.0336
Schistosoma mansoni bromodomain containing protein 0.0066 0.0596 0.0786
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0032 0.0231 0.035
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.014 0.048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.152 0.4782
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0923 0.3174
Schistosoma mansoni hypothetical protein 0.0048 0.0408 0.0538
Echinococcus granulosus disco interacting protein 2 0.0039 0.031 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.014 0.0481
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0546 0.1621
Brugia malayi jmjC domain containing protein 0.0075 0.0695 0.2392
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0022 0.0029
Treponema pallidum phosphoglycerate kinase 0.0086 0.0814 0.7353
Echinococcus granulosus geminin 0.0719 0.758 1
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0161 0.0242
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0165 0.2027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0104 0.1281
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.2908 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.152 0.4782
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0032 0.0039
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0211 0.2588
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0923 0.1426
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0012 0.0022 0.0029
Echinococcus granulosus phd:f box containing protein 0.0019 0.0096 0.0127
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0032 0.0231 0.035
Echinococcus multilocularis 0.0025 0.0161 0.0161
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0406 0.1573
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Brugia malayi RNA, U transporter 1 0.0082 0.0768 0.2641
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0049 0.0418 0.1438
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0096 0.0096
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0118 0.1451
Brugia malayi jmjC domain containing protein 0.0019 0.0096 0.0332
Echinococcus multilocularis axis inhibition protein axin 0.0048 0.0407 0.0407
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.002 0.0107 0.1125
Echinococcus multilocularis disco interacting protein 2 0.0039 0.031 0.031
Echinococcus multilocularis Chromo domain 0.0023 0.014 0.014
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.007
Echinococcus granulosus dna polymerase kappa 0.0061 0.0546 0.0721
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0022 0.0022
Echinococcus granulosus axis inhibition protein axin 0.0048 0.0407 0.0537
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0012 0.0022 0.0022
Brugia malayi Phosphoglycerate kinase 0.0032 0.0231 0.0794
Plasmodium falciparum DNA repair protein REV1, putative 0.0011 0.0006 0.0076
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0116 0.0365
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0096 0.014
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0012 0.0022 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.0297 0.3071 0.4052
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0118 0.1385
Entamoeba histolytica hypothetical protein 0.0042 0.0341 0.3045
Echinococcus granulosus cpg binding protein 0.0067 0.0607 0.0801
Brugia malayi jmjC domain containing protein 0.0019 0.0096 0.0332
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0119 0.0375
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.0546 0.084
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0077 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.0546 0.1621
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0104 0.113
Trichomonas vaginalis dullard protein, putative 0.0025 0.0161 0.057
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0084 0.0264
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0923 0.1426
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0211 0.2223
Schistosoma mansoni hypothetical protein 0.0021 0.0116 0.0153
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0161 0.1329
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0165 0.0218
Brugia malayi Protein cec-1. 0.0023 0.014 0.048
Brugia malayi ImpB/MucB/SamB family protein 0.0034 0.0258 0.0889
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0211 0.2283
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0104 0.0336
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.002 0.0107 0.1242
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0341 0.045
Loa Loa (eye worm) G protein alpha subunit 3 0.0012 0.0022 0.007
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.014 0.1474
Echinococcus multilocularis chromobox protein 2 0.0023 0.014 0.014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0408 0.0538
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0294 0.0448
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0104 0.1214
Schistosoma mansoni importin beta-1 0.0029 0.02 0.0265
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0104 0.0783
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0231 0.035
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.002 0.0107 0.0141
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0407 0.1577
Brugia malayi CHD4 protein 0.0027 0.0178 0.0613
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0119 0.0176
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0096 0.0127
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0079 0.0738 0.2933
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.2908 0.3836
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0119 0.1258
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0039 0.031 0.0409
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0165 0.1363
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0096 0.0304
Plasmodium falciparum JmjC domain-containing protein, putative 0.0019 0.0096 0.1185
Schistosoma mansoni 6-phosphofructokinase 0.011 0.107 0.1411
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0216 0.0327
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0077 0.0102
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0041 0.033 0.0504
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0096 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0407 0.1577
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0032 0.0231 0.035
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0612 0.6433 1
Brugia malayi phosphofructokinase 0.011 0.107 0.3679
Brugia malayi A-kinase anchor protein 10, precursor 0.0048 0.0407 0.1401
Echinococcus multilocularis regulator of G protein signaling 3 0.0048 0.0407 0.0407
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0211 0.0771
Loa Loa (eye worm) hypothetical protein 0.0023 0.0138 0.0433
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0099 0.0144
Schistosoma mansoni hypothetical protein 0.0048 0.0408 0.0538
Echinococcus multilocularis importin subunit beta 1 0.0029 0.02 0.02
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0161 0.1983
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0211 0.2531
Schistosoma mansoni chromobox protein 0.0141 0.1401 0.1849
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0012 0.0022 0.007
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0612 0.6433 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0178 0.0637
Echinococcus multilocularis Chromobox protein 3 0.0023 0.014 0.014
Trypanosoma cruzi ISWI complex protein 0.0015 0.0058 0.0081
Schistosoma mansoni ap endonuclease 0.002 0.0104 0.0138
Brugia malayi hypothetical protein 0.0048 0.0407 0.1401
Loa Loa (eye worm) hypothetical protein 0.0039 0.031 0.0975
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0096 0.014
Echinococcus multilocularis cpg binding protein 0.0067 0.0607 0.0607
Entamoeba histolytica hypothetical protein 0.0048 0.0407 0.3677
Schistosoma mansoni terminal deoxycytidyl transferase 0.0034 0.0258 0.0341
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0304
Loa Loa (eye worm) hypothetical protein 0.0062 0.0556 0.1748
Onchocerca volvulus 0.0039 0.031 0.1178
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0546 0.084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.0546 0.084
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0049 0.0418 0.1315
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0086 0.0814 0.8592
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0408 0.0538
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0294 0.0448
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0077 0.0102
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0096 0.1018
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0012 0.0022 0.0029
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0085 0.0803 0.3196
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0211 0.0771
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.107 0.3365
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0086 0.0809 0.9936
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.0407 0.0407
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0612 0.6433 1
Onchocerca volvulus 0.024 0.2464 1
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0048 0.0407 0.0537
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.014 0.1121
Schistosoma mansoni axis inhibition protein axin 0.0048 0.0407 0.0537
Mycobacterium tuberculosis Conserved hypothetical protein 0.0034 0.0258 0.0477
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0119 0.0176
Brugia malayi hypothetical protein 0.0023 0.014 0.048
Loa Loa (eye worm) hypothetical protein 0.0086 0.0814 0.2561
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0022 0.0029
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0012 0.0022 0.0076
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Echinococcus granulosus Regulator of G protein signaling 20 0.0048 0.0407 0.0537
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0048 0.0407 0.1282
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0119 0.1399
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.0695 0.0917
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0211 0.0772
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0086 0.0814 0.3243
Echinococcus granulosus GPCR family 2 0.0048 0.0408 0.0538
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0406 0.1573
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Loa Loa (eye worm) hypothetical protein 0.0059 0.0524 0.1649
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0161 0.057
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.014 0.0481
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0211 0.0772
Echinococcus granulosus regulator of G protein signaling 3 0.0048 0.0407 0.0537
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Onchocerca volvulus 0.0063 0.0568 0.2237
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0165 0.0519
Schistosoma mansoni regulator of G protein signaling 0.0048 0.0407 0.0537
Echinococcus granulosus chromobox protein 2 0.0023 0.014 0.0184
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0297 0.3071 0.9663
Trypanosoma brucei unspecified product 0.0054 0.0475 0.0729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.2908 0.3836
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0282 0.0282
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.014 0.048
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0012 0.0022 0.007
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0096 0.014
Echinococcus granulosus phosphoglycerate kinase 1 0.0086 0.0814 0.1074
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.014 0.1715
Loa Loa (eye worm) hypothetical protein 0.0012 0.0022 0.007
Echinococcus granulosus DNA methyltransferase 2, putative 0.002 0.0107 0.0141
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0771 0.1017
Schistosoma mansoni hypothetical protein 0.0015 0.0058 0.0077
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0012 0.0022 0.0076
Echinococcus multilocularis beta adrenergic receptor kinase 0.0297 0.3071 0.3071
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0282 0.0372
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.0407 0.0537
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0812 0.1254
Brugia malayi Importin beta-1 subunit 0.0029 0.02 0.069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.014 0.0481
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0738 0.2933
Echinococcus multilocularis GPCR, family 2 0.0048 0.0408 0.0408
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0408 0.0408
Trypanosoma brucei ISWI complex protein 0.0015 0.0058 0.0081
Echinococcus granulosus zinc finger protein 0.0021 0.0123 0.0162
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0012 0.0022 0.0076
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0557 0.0735
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0012 0.0022 0.0029
Brugia malayi SET domain containing protein 0.0025 0.0158 0.0545
Echinococcus multilocularis geminin 0.0719 0.758 0.758
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0491 0.1922
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0098 0.0129
Loa Loa (eye worm) hypothetical protein 0.0038 0.0294 0.0925
Schistosoma mansoni hypothetical protein 0.0719 0.758 1
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.002 0.0107 0.1309
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.014 0.1715
Echinococcus granulosus snurportin 1 0.0307 0.3179 0.4193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.2908 0.2908
Trichomonas vaginalis chromobox protein, putative 0.0023 0.014 0.0481
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0096 0.0127
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0165 0.0247
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0923 0.3688
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.014 0.1652
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0211 0.0771
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0012 0.0022 0.0022
Echinococcus multilocularis regulator of G protein signaling 7 0.0048 0.0407 0.0407
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0086 0.0814 1
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0012 0.0022 0.0076
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0086 0.0814 0.1257
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0165 0.0218
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0012 0.0022 0.0029
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0524 0.0691
Trypanosoma brucei DNA polymerase IV, putative 0.0054 0.0475 0.0729
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0054 0.047 0.062
Schistosoma mansoni axis inhibition protein axin 0.0048 0.0407 0.0537
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0104 0.0153
Schistosoma mansoni cpg binding protein 0.0067 0.0607 0.0801
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0923 0.1426
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.107 0.1655
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.152 0.5228
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0923 0.3688
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.107 0.4289
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0012 0.0022 0.0029
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0096 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.0546 0.084
Brugia malayi Pre-SET motif family protein 0.0211 0.2153 0.7405
Echinococcus granulosus regulator of G protein signaling 7 0.0048 0.0407 0.0537
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0011 0.0006 0.0065
Loa Loa (eye worm) hypothetical protein 0.0048 0.0407 0.1282
Entamoeba histolytica Ran family GTPase 0.0021 0.0119 0.0926
Trypanosoma brucei phosphoglycerate kinase 0.0032 0.0231 0.035
Echinococcus granulosus regulator of G protein signaling 7 0.0048 0.0407 0.0537
Echinococcus multilocularis zinc finger protein 0.0021 0.0123 0.0123
Onchocerca volvulus Alhambra homolog 0.0059 0.0524 0.2055
Loa Loa (eye worm) RGS-3 protein 0.0048 0.0407 0.1282
Onchocerca volvulus 0.0023 0.014 0.0481
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.107 0.4289
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0032 0.0231 0.035
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0439
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0119 0.1465
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.02 0.0302
Trypanosoma brucei phosphoglycerate kinase 0.0086 0.0814 0.1257

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 1 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 3.81 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 3.91 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 4.67 % ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro ChEMBL. No reference
Inhibition (functional) = 28 % GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. ChEMBL. 20485427
Inhibition (functional) = 37 % GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition (functional) = 87 % GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM ChEMBL. 20485427
Inhibition frequency index (IFI) (functional) = 3.39 Inhibition Frequency Index (IFI) GSK. 20485427
Percent growth inhibition (functional) = 1 % Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 28 % Percent inhibition of HepG2 growth (at 10 uM) GSK. 20485427
Percent growth inhibition (functional) = 37 % Percent inhibition of P. falciparum Dd2 growth (at 2 uM) GSK. 20485427
Percent growth inhibition (functional) = 87 % Percent inhibition of P. falciparum 3D7 growth (at 2 uM) GSK. 20485427
XC50 (functional) = 5.98 XC50 determination of P. falciparum 3D7 growth GSK. 20485427
XC50 (functional) = 1.04918 uM GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. ChEMBL. 20485427

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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