Detailed information for compound 596309
Basic information
Technical information
- TDR Targets ID: 596309
- Name: N-(3-chloro-4-methylphenyl)-5-methyl-2-(trifl uoromethyl)-[1,2,4]triazolo[5,1-b]pyrimidin-7 -amine
- MW: 341.719 | Formula: C14H11ClF3N5
-
H donors: 1
H acceptors: 3
LogP: 4.28
Rotable bonds: 3
Rule of 5 violations (Lipinski): 1 - SMILES: Cc1cc(Nc2ccc(c(c2)Cl)C)n2c(n1)nc(n2)C(F)(F)F
- InChi: 1S/C14H11ClF3N5/c1-7-3-4-9(6-10(7)15)20-11-5-8(2)19-13-21-12(14(16,17)18)22-23(11)13/h3-6,20H,1-2H3
- InChiKey: VLUCXPDTWDLJRX-UHFFFAOYSA-N
Network
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Synonyms
- N-(3-chloro-4-methyl-phenyl)-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine
- (3-chloro-4-methyl-phenyl)-[5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[5,1-b]pyrimidin-7-yl]amine
- ZINC07636162
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Plasmodium falciparum | lysine--tRNA ligase | Starlite/ChEMBL | No references |
| Plasmodium falciparum | hexose transporter | Starlite/ChEMBL | No references |
| Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 1 | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 4 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 7 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | dihydroorotate dehydrogenase | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 6 | Starlite/ChEMBL | No references |
| Leishmania mexicana | glucose transporter, lmgt2 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Proline--tRNA ligase | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0933 | 0.2167 |
| Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0113 | 0.1441 | 0.2834 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0063 | 0.0037 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0063 | 0.0018 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Brugia malayi | beta-lactamase | 0.0035 | 0.0309 | 0.0536 |
| Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.3234 |
| Toxoplasma gondii | histone lysine demethylase JMJD6a | 0.002 | 0.0089 | 0.0052 |
| Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.3234 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0309 | 0.0563 |
| Trypanosoma cruzi | hexose transporter | 0.0039 | 0.0371 | 0.0768 |
| Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0117 | 0.0174 |
| Toxoplasma gondii | WD domain, G-beta repeat-containing protein | 0.002 | 0.0092 | 0.006 |
| Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0359 | 0.4971 | 1 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0263 | 0.3595 | 1 |
| Brugia malayi | N-terminal motif family protein | 0.0189 | 0.2536 | 0.5057 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.0371 | 0.0873 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0063 | 0.0018 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0039 | 0.0364 | 0.0617 |
| Echinococcus multilocularis | Sugar transporter ERD6 protein | 0.0018 | 0.0063 | 0.0018 |
| Schistosoma mansoni | hypothetical protein | 0.0245 | 0.3338 | 0.3307 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0364 | 0.3384 |
| Schistosoma mansoni | hypothetical protein | 0.0708 | 1 | 1 |
| Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0042 | 0.0408 | 0.0859 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0309 | 0.0563 |
| Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0359 | 0.4971 | 1 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0353 | 0.0309 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Brugia malayi | Cam kinase protein 1 | 0.0039 | 0.0364 | 0.0648 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0364 | 0.0321 |
| Schistosoma mansoni | cpg binding protein | 0.0031 | 0.0248 | 0.0204 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.025 | 0.0444 |
| Leishmania major | mitochondrial DNA polymerase beta | 0.0296 | 0.4076 | 1 |
| Echinococcus granulosus | Jumonji AT rich interactive domain 1B | 0.0021 | 0.0114 | 0.0069 |
| Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0126 | 0.1625 | 0.3201 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.0309 | 0.0834 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0182 | 0.2426 | 0.6691 |
| Loa Loa (eye worm) | jmjC domain-containing protein | 0.002 | 0.0089 | 0.0116 |
| Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.3234 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0443 | 0.0947 |
| Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1678 | 0.3332 |
| Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0309 | 0.0504 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0309 | 0.033 |
| Echinococcus multilocularis | lysine specific demethylase 5A | 0.0073 | 0.0862 | 0.0821 |
| Loa Loa (eye worm) | sugar transporter | 0.0018 | 0.0063 | 0.0064 |
| Echinococcus multilocularis | JmjC domain containing protein 4 | 0.002 | 0.0089 | 0.0044 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0039 | 0.0364 | 0.0404 |
| Schistosoma mansoni | hypothetical protein | 0.0435 | 0.6077 | 0.6059 |
| Onchocerca volvulus | Alhambra homolog | 0.006 | 0.0679 | 0.2489 |
| Loa Loa (eye worm) | PHD-finger family protein | 0.006 | 0.0679 | 0.131 |
| Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0031 | 0.0248 | 0.0438 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.0364 | 0.0852 |
| Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0073 | 0.0014 |
| Leishmania major | glucose transporter, lmgt3 | 0.0039 | 0.0371 | 0.0768 |
| Brugia malayi | AF-10 protein | 0.002 | 0.0092 | 0.0096 |
| Plasmodium falciparum | lysine--tRNA ligase | 0.0028 | 0.0213 | 0.0201 |
| Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0039 | 0.0364 | 0.0404 |
| Loa Loa (eye worm) | jmjC domain-containing protein | 0.002 | 0.0089 | 0.0116 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0063 | 0.0037 |
| Brugia malayi | latrophilin 2 splice variant baaae | 0.0245 | 0.3338 | 0.6683 |
| Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0933 | 0.2462 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0309 | 0.0834 |
| Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0039 | 0.0364 | 0.075 |
| Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.3338 | 0.6693 |
| Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0039 | 0.0364 | 0.0674 |
| Loa Loa (eye worm) | sugar transporter | 0.0126 | 0.1625 | 0.3227 |
| Echinococcus granulosus | lysine specific demethylase 6a | 0.002 | 0.0089 | 0.0044 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Toxoplasma gondii | prolyl-tRNA synthetase (ProRS) | 0.0044 | 0.0443 | 0.0779 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0309 | 0.0614 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0353 | 0.0651 |
| Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.0309 | 0.115 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Echinococcus multilocularis | GPCR, family 2 | 0.0113 | 0.1441 | 0.1403 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Schistosoma mansoni | hypothetical protein | 0.0126 | 0.1625 | 0.1588 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.0364 | 0.0321 |
| Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0073 | 0.0025 |
| Plasmodium vivax | proline--tRNA ligase, putative | 0.0044 | 0.0443 | 0.051 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0073 | 0.0025 |
| Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0073 | 0.0057 |
| Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.0933 | 0.2462 |
| Schistosoma mansoni | jumonji domain containing protein | 0.0157 | 0.2074 | 0.2039 |
| Echinococcus granulosus | General substrate transporter | 0.0108 | 0.137 | 0.1331 |
| Plasmodium falciparum | hexose transporter | 0.0126 | 0.1625 | 0.2094 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.0309 | 0.115 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Mycobacterium ulcerans | fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT | 0.0018 | 0.0063 | 0.0234 |
| Loa Loa (eye worm) | jmjC domain-containing protein | 0.0075 | 0.0887 | 0.1732 |
| Echinococcus multilocularis | phd:f box containing protein | 0.002 | 0.0089 | 0.0044 |
| Echinococcus granulosus | JmjC domain containing protein 4 | 0.002 | 0.0089 | 0.0044 |
| Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0073 | 1 |
| Echinococcus multilocularis | lysyl tRNA synthetase | 0.0028 | 0.0213 | 0.0169 |
| Plasmodium vivax | hypothetical protein, conserved | 0.0022 | 0.0119 | 0.0075 |
| Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0039 | 0.0364 | 0.0404 |
| Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1192 | 0.1152 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0039 | 0.0364 | 0.0321 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0182 | 0.2426 | 0.6691 |
| Plasmodium falciparum | phd finger protein, putative | 0.006 | 0.0679 | 0.0825 |
| Brugia malayi | jmjC domain containing protein | 0.002 | 0.0089 | 0.0089 |
| Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0039 | 0.0364 | 0.0674 |
| Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0309 | 0.0614 |
| Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.0309 | 0.115 |
| Plasmodium falciparum | proline--tRNA ligase | 0.0044 | 0.0443 | 0.051 |
| Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.02 | 0.2689 | 0.6545 |
| Schistosoma mansoni | dihydroorotate dehydrogenase | 0.02 | 0.2689 | 0.2656 |
| Plasmodium vivax | hypothetical protein, conserved | 0.006 | 0.0679 | 0.0825 |
| Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0051 | 0.0539 | 0.1186 |
| Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0213 | 0.1628 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0263 | 0.3595 | 1 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.4971 | 1 |
| Loa Loa (eye worm) | transcription factor SMAD2 | 0.0242 | 0.3294 | 0.6604 |
| Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.1828 | 0.4397 |
| Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0309 | 0.0697 |
| Plasmodium vivax | CDK-related protein kinase 6, putative | 0.0536 | 0.7523 | 1 |
| Plasmodium vivax | hexose transporter | 0.0126 | 0.1625 | 0.2094 |
| Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0309 | 0.0697 |
| Trypanosoma brucei | glucose transporter 1E | 0.0039 | 0.0371 | 0.0768 |
| Plasmodium vivax | JmjC domain containing protein | 0.002 | 0.0089 | 0.0034 |
| Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0679 | 0.131 |
| Plasmodium falciparum | JmjC domain-containing protein, putative | 0.002 | 0.0089 | 0.0034 |
| Toxoplasma gondii | histone lysine demethylase JMJC1/KDM5D/JARID1D | 0.002 | 0.0089 | 0.0052 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.0371 | 0.0873 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0263 | 0.3595 | 1 |
| Schistosoma mansoni | protein phosphatase 2C | 0.002 | 0.0089 | 0.0044 |
| Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.0309 | 0.062 |
| Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0073 | 0.0028 |
| Leishmania major | glucose transporter, lmgt2 | 0.0039 | 0.0371 | 0.0768 |
| Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0933 | 0.2462 |
| Echinococcus multilocularis | PHD finger protein rhinoceros | 0.006 | 0.0679 | 0.0637 |
| Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0309 | 0.0265 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.0063 | 0.0064 |
| Trypanosoma brucei | glucose transporter 2A | 0.0039 | 0.0371 | 0.0768 |
| Echinococcus granulosus | jumonji domain containing protein | 0.0084 | 0.102 | 0.0979 |
| Brugia malayi | jmjC domain containing protein | 0.002 | 0.0089 | 0.0089 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0309 | 0.0563 |
| Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0408 | 0.0859 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.0213 | 0.0169 |
| Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.1678 | 0.6528 |
| Brugia malayi | CXXC zinc finger family protein | 0.0031 | 0.0248 | 0.0411 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0021 | 0.0116 | 0.0131 |
| Schistosoma mansoni | hypothetical protein | 0.0708 | 1 | 1 |
| Brugia malayi | PHD-finger family protein | 0.0022 | 0.0117 | 0.0147 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0027 | 0.0201 | 0.0157 |
| Mycobacterium ulcerans | integral membrane transport protein | 0.0018 | 0.0063 | 0.0234 |
| Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.2689 | 0.3521 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Entamoeba histolytica | prolyl-tRNA synthetase, putative | 0.0038 | 0.0353 | 0.3253 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0065 | 0.0741 | 0.0699 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.0364 | 0.3384 |
| Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0073 | 0.0025 |
| Brugia malayi | lysyl-tRNA synthetase | 0.0028 | 0.0213 | 0.0341 |
| Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.0309 | 0.0834 |
| Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0309 | 0.0834 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0039 | 0.0364 | 0.0617 |
| Onchocerca volvulus | Huntingtin homolog | 0.013 | 0.1678 | 0.6528 |
| Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.4076 | 1 |
| Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.0309 | 0.0834 |
| Schistosoma mansoni | jumonji domain containing protein | 0.002 | 0.0089 | 0.0044 |
| Giardia lamblia | PHD finger protein 15 | 0.006 | 0.0679 | 1 |
| Plasmodium falciparum | conserved Plasmodium membrane protein, unknown function | 0.0022 | 0.0119 | 0.0075 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0028 | 0.0213 | 0.0425 |
| Plasmodium falciparum | protein kinase 6 | 0.0536 | 0.7523 | 1 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.2689 | 1 |
| Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.02 | 0.2689 | 0.8902 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.1625 | 0.1588 |
| Brugia malayi | Zinc finger, C2H2 type family protein | 0.0078 | 0.0933 | 0.1802 |
| Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0351 | 0.0308 |
| Brugia malayi | jmjC domain containing protein | 0.002 | 0.0089 | 0.0089 |
| Brugia malayi | hypothetical protein | 0.013 | 0.1678 | 0.3314 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0443 | 0.0947 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.002 | 0.0089 | 0.0064 |
| Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0018 | 0.0063 | 0.0018 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0309 | 0.0563 |
| Onchocerca volvulus | 0.0035 | 0.0309 | 0.0995 | |
| Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.3013 | 1 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0063 | 0.0018 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0443 | 0.0947 |
| Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0089 | 0.0116 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Toxoplasma gondii | PHD-finger domain-containing protein | 0.006 | 0.0679 | 0.1261 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Toxoplasma gondii | cell-cycle-associated protein kinase MAPK, putative | 0.0204 | 0.2745 | 0.5495 |
| Onchocerca volvulus | 0.0035 | 0.0309 | 0.0995 | |
| Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.02 | 0.2689 | 0.5381 |
| Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.0933 | 0.0892 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.0063 | 0.0037 |
| Schistosoma mansoni | ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related | 0.002 | 0.0089 | 0.0044 |
| Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0096 | 0.1192 | 0.2329 |
| Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.0933 | 0.0892 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.0213 | 0.0792 |
| Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0073 | 0.0021 |
| Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0273 | 0.0229 |
| Echinococcus multilocularis | jumonji domain containing 1A | 0.002 | 0.0089 | 0.0044 |
| Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0933 | 0.2462 |
| Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0309 | 0.0536 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.0213 | 0.0792 |
| Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.0309 | 0.115 |
| Echinococcus multilocularis | jumonji domain containing protein | 0.0084 | 0.102 | 0.0979 |
| Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0309 | 0.0697 |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | 0.0204 | 0.2745 | 0.3595 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Giardia lamblia | Prolyl-tRNA synthetase | 0.0038 | 0.0353 | 0.4707 |
| Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0213 | 0.0368 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.0371 | 0.0873 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1192 | 0.1152 |
| Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 0.2689 | 0.6545 |
| Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0038 | 0.0353 | 0.082 |
| Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0309 | 0.0265 |
| Schistosoma mansoni | nuclear transcription factor X-box binding 1 (nfx1) | 0.0018 | 0.0063 | 0.0018 |
| Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0073 | 0.0272 |
| Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1192 | 0.1152 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.1828 | 0.4397 |
| Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0039 | 0.0364 | 0.0404 |
| Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0045 | 0.0028 |
| Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0039 | 0.0371 | 0.0768 |
| Echinococcus granulosus | calcium dependent protein kinase | 0.0036 | 0.033 | 0.0286 |
| Toxoplasma gondii | hypothetical protein | 0.0048 | 0.0496 | 0.0887 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.0213 | 0.0169 |
| Trypanosoma brucei | bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0443 | 0.0947 |
| Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0039 | 0.0364 | 0.0404 |
| Brugia malayi | Sugar transporter family protein | 0.0126 | 0.1625 | 0.3208 |
| Brugia malayi | PHD-finger family protein | 0.006 | 0.0679 | 0.1286 |
| Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0078 | 0.0933 | 1 |
| Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.02 | 0.2689 | 0.6545 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0263 | 0.3595 | 1 |
| Schistosoma mansoni | hypothetical protein | 0.002 | 0.0092 | 0.0047 |
| Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0198 | 0.2661 | 0.2628 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0364 | 0.0321 |
| Brugia malayi | jmjC domain containing protein | 0.0198 | 0.2661 | 0.531 |
| Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.0309 | 0.0834 |
| Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1301 | 0.257 |
| Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0042 | 0.0408 | 0.0859 |
| Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0039 | 0.0364 | 0.0404 |
| Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.2536 | 0.507 |
| Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0073 | 0.0039 |
| Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.0309 | 0.0834 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0309 | 0.0563 |
| Leishmania major | protein kinase, putative | 0.0039 | 0.0364 | 0.075 |
| Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0309 | 0.0265 |
| Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0078 | 0.0933 | 0.0892 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0353 | 0.0651 |
| Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.0309 | 0.0834 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Echinococcus multilocularis | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0353 | 0.0309 |
| Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0198 | 0.2661 | 0.2628 |
| Brugia malayi | hypothetical protein | 0.0038 | 0.0351 | 0.0622 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.0063 | 0.0018 |
| Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0073 | 0.0029 |
| Trypanosoma brucei | lysyl-tRNA synthetase, putative | 0.0028 | 0.0213 | 0.0374 |
| Schistosoma mansoni | phd/f-box containing protein | 0.002 | 0.0089 | 0.0044 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.0063 | 0.0037 |
| Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0096 | 0.1192 | 0.1152 |
| Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0933 | 0.2462 |
| Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0078 | 0.0933 | 0.2462 |
| Echinococcus granulosus | cpg binding protein | 0.0032 | 0.0273 | 0.0229 |
| Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0309 | 0.0536 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.0063 | 0.0037 |
| Echinococcus granulosus | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0353 | 0.0309 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1441 | 0.2854 |
| Echinococcus multilocularis | General substrate transporter | 0.0108 | 0.137 | 0.1331 |
| Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0075 | 0.0887 | 0.0846 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Loa Loa (eye worm) | jmjC domain-containing protein | 0.0125 | 0.1606 | 0.3188 |
| Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0073 | 0.0028 |
| Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1441 | 0.1403 |
| Mycobacterium ulcerans | sugar-transport integral membrane protein SugI | 0.0018 | 0.0063 | 0.0234 |
| Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0309 | 0.0563 |
| Toxoplasma gondii | PHD-finger domain-containing protein | 0.002 | 0.0092 | 0.006 |
| Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0309 | 0.0265 |
| Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0113 | 0.1441 | 0.1403 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.0063 | 0.0064 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0371 | 0.0873 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0371 | 0.0873 |
| Echinococcus multilocularis | peregrin | 0.006 | 0.0679 | 0.0637 |
| Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.006 | 0.0679 | 0.0637 |
| Leishmania major | glucose transporter, lmgt1 | 0.0039 | 0.0371 | 0.0768 |
| Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0058 | 0.0641 | 0.1185 |
| Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0039 | 0.0364 | 0.0648 |
| Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0126 | 0.1625 | 0.4423 |
| Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.4076 | 1 |
| Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.0309 | 0.062 |
| Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0073 | 0.0025 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0351 | 0.0308 |
| Echinococcus granulosus | peregrin | 0.006 | 0.0679 | 0.0637 |
| Brugia malayi | F/Y-rich N-terminus family protein | 0.0029 | 0.0227 | 0.0369 |
| Plasmodium vivax | lysine--tRNA ligase, putative | 0.0028 | 0.0213 | 0.0201 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0353 | 0.0309 |
| Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.02 | 0.2689 | 0.6545 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0443 | 0.0947 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0039 | 0.0364 | 0.0617 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.0371 | 0.0873 |
| Loa Loa (eye worm) | jmjC domain-containing protein | 0.002 | 0.0089 | 0.0116 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0113 | 0.1441 | 0.1403 |
| Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0309 | 0.0563 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Echinococcus multilocularis | Jumonji, AT rich interactive domain 1B | 0.0021 | 0.0114 | 0.0069 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0025 | 0.0163 | 0.0284 |
| Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0309 | 0.0536 |
| Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0263 | 0.3595 | 0.7206 |
| Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0359 | 0.4971 | 1 |
| Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.02 | 0.2689 | 1 |
| Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.0309 | 0.0697 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.2689 | 0.5368 |
| Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0364 | 0.0674 |
| Echinococcus multilocularis | calcium dependent protein kinase | 0.0036 | 0.033 | 0.0286 |
| Echinococcus multilocularis | cpg binding protein | 0.0032 | 0.0273 | 0.0229 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.0371 | 0.0873 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0028 | 0.0213 | 0.0241 |
| Plasmodium falciparum | dihydroorotate dehydrogenase | 0.02 | 0.2689 | 0.3521 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.0063 | 0.0018 |
| Echinococcus multilocularis | geminin | 0.0708 | 1 | 1 |
| Echinococcus multilocularis | dnaJ subfamily B | 0.0435 | 0.6077 | 0.6059 |
| Echinococcus granulosus | lysyl tRNA synthetase | 0.0028 | 0.0213 | 0.0169 |
| Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0045 | 0.0028 |
| Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.02 | 0.2689 | 1 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0063 | 0.0037 |
| Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0189 | 0.2536 | 1 |
| Schistosoma mansoni | glucose transporter | 0.0018 | 0.0063 | 0.0018 |
| Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0351 | 0.0308 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Echinococcus granulosus | jumonji domain containing 1A | 0.002 | 0.0089 | 0.0044 |
| Plasmodium falciparum | protein kinase 7 | 0.0357 | 0.4944 | 0.6542 |
| Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0113 | 0.1441 | 0.1403 |
| Echinococcus granulosus | Sugar transporter ERD6 protein | 0.0018 | 0.0063 | 0.0018 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Trichomonas vaginalis | esterase, putative | 0.0035 | 0.0309 | 0.0697 |
| Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0028 | 0.0213 | 0.0374 |
| Plasmodium vivax | mitogen-activated protein kinase 2, putative | 0.0204 | 0.2745 | 0.3595 |
| Leishmania major | hypothetical protein, conserved | 0.002 | 0.0089 | 0.0064 |
| Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0045 | 0.0028 |
| Echinococcus granulosus | lysine specific demethylase 5A | 0.0075 | 0.0887 | 0.0846 |
| Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.0309 | 0.0834 |
| Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0039 | 0.0364 | 0.0404 |
| Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0296 | 0.4076 | 1 |
| Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0075 | 0.0887 | 0.0846 |
| Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0073 | 0.0029 |
| Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0073 | 0.0028 |
| Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.2056 | 0.7644 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.0364 | 0.0321 |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0039 | 0.0364 | 0.0404 |
| Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0078 | 0.0933 | 0.0892 |
| Echinococcus multilocularis | lysine specific demethylase 6a | 0.002 | 0.0089 | 0.0044 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.0063 | 0.0037 |
| Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1441 | 0.1403 |
| Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0073 | 0.0028 |
| Brugia malayi | Bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0353 | 0.0625 |
| Toxoplasma gondii | PHD-finger domain-containing protein | 0.006 | 0.0679 | 0.1261 |
| Echinococcus granulosus | synaptic vesicle 2 protein | 0.0018 | 0.0063 | 0.0018 |
| Onchocerca volvulus | Glucosylceramidase homolog | 0.0173 | 0.2293 | 0.9015 |
| Toxoplasma gondii | protein kinase, putative | 0.0357 | 0.4944 | 1 |
| Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.1828 | 0.4397 |
| Mycobacterium ulcerans | sugar transporter | 0.0018 | 0.0063 | 0.0234 |
| Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0073 | 0.0166 |
| Leishmania major | lysyl-tRNA synthetase, putative | 0.0028 | 0.0213 | 0.0374 |
| Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.0309 | 0.115 |
| Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.1678 | 0.3332 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0063 | 0.0037 |
| Brugia malayi | Bromodomain containing protein | 0.006 | 0.0679 | 0.1286 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.0364 | 0.0321 |
| Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0351 | 0.0308 |
| Schistosoma mansoni | hypothetical protein | 0.006 | 0.0679 | 0.0637 |
| Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0096 | 0.1192 | 0.235 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0042 | 0.0408 | 0.0859 |
| Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0351 | 0.3234 |
| Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.0309 | 0.0834 |
| Leishmania major | dihydroorotate dehydrogenase | 0.02 | 0.2689 | 0.6545 |
| Echinococcus granulosus | dnaJ subfamily B | 0.0435 | 0.6077 | 0.6059 |
| Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0113 | 0.1441 | 0.1403 |
| Echinococcus granulosus | phd:f box containing protein | 0.002 | 0.0089 | 0.0044 |
| Trypanosoma cruzi | JmjC domain, hydroxylase, putative | 0.002 | 0.0089 | 0.0064 |
| Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0038 | 0.0353 | 0.0791 |
| Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0263 | 0.3595 | 0.7214 |
| Giardia lamblia | Lysyl-tRNA synthetase | 0.0028 | 0.0213 | 0.2439 |
| Onchocerca volvulus | 0.0035 | 0.0309 | 0.0995 | |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0263 | 0.3595 | 1 |
| Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0309 | 0.0614 |
| Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.0309 | 0.0697 |
| Onchocerca volvulus | 0.0031 | 0.0248 | 0.0746 | |
| Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1192 | 0.1152 |
| Echinococcus granulosus | PHD finger protein rhinoceros | 0.006 | 0.0679 | 0.0637 |
| Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.02 | 0.2689 | 0.5368 |
| Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1441 | 0.1403 |
| Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0096 | 0.1192 | 0.1152 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Chlamydia trachomatis | lysine--tRNA ligase | 0.0028 | 0.0213 | 1 |
| Brugia malayi | jmjC domain containing protein | 0.002 | 0.0089 | 0.0089 |
| Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.002 | 0.0092 | 0.0073 |
| Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0309 | 0.0563 |
| Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0353 | 0.0625 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.0063 | 0.0037 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Brugia malayi | MH2 domain containing protein | 0.0242 | 0.3294 | 0.6594 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0152 | 0.0302 |
| Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0309 | 0.0614 |
| Brugia malayi | jmjC domain containing protein | 0.0075 | 0.0887 | 0.1709 |
| Trypanosoma brucei | PHD-zinc-finger like domain containing protein, putative | 0.002 | 0.0092 | 0.0073 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0063 | 0.0064 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0371 | 0.0768 |
| Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0039 | 0.0364 | 0.0404 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0263 | 0.3595 | 1 |
| Trypanosoma brucei | JmjC domain, hydroxylase, putative | 0.002 | 0.0089 | 0.0064 |
| Toxoplasma gondii | lysine-tRNA ligase | 0.0028 | 0.0213 | 0.0308 |
| Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.2056 | 0.6754 |
| Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0073 | 0.0035 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.1625 | 0.1588 |
| Schistosoma mansoni | phosphatidylserine receptor | 0.002 | 0.0089 | 0.0044 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 2 LysX | 0.0024 | 0.0152 | 0.0302 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.1625 | 0.1588 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.0063 | 0.0037 |
| Echinococcus granulosus | GPCR family 2 | 0.0113 | 0.1441 | 0.1403 |
| Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0089 | 0.0116 |
| Brugia malayi | Latrophilin receptor protein 2 | 0.0113 | 0.1441 | 0.2834 |
| Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0113 | 0.1441 | 0.2854 |
| Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1441 | 0.1403 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.1625 | 0.1588 |
| Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0073 | 0.0085 |
| Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0096 | 0.1192 | 0.1152 |
| Loa Loa (eye worm) | MH2 domain-containing protein | 0.0242 | 0.3294 | 0.6604 |
| Trichomonas vaginalis | glucosylceramidase, putative | 0.0173 | 0.2293 | 0.6312 |
| Schistosoma mansoni | cpg binding protein | 0.0032 | 0.0273 | 0.0229 |
| Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0073 | 0.0014 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| EC50 (functional) | = 6.71 nM | MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). | ChEMBL. | No reference |
| EC50 (functional) | = 14.1 nM | MMV: Inhibition of Plasmodium falciparum K1 (EC50). | ChEMBL. | No reference |
| Growth Inhibition (functional) | = 1.818 % | MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. | ChEMBL. | No reference |
| IC50 (binding) | = 130 nM | BindingDB_Patents: Inhibiton Assay. For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002) JBiol Chem., 277, 41827-41834, and Baldwin, et al. (2005) J. Biol. Chem., 280. 21847-21853.Briefly, this colorimetric assay monitors the reduction of 2,6-dichloroindophenol (DCIP) at 600 nm (e = 18.8 mM-1cm-1) for measuring DHOD inhibition. The assay was carried out using a solution containing 100 mM HEPES, pH 8.0, 150 mM NaCl, 10% glycerol, 0.1% Triton X-100, 20 micro molar CoQD (coenzyme QD), 200 micro molar L-dihydroorotate, and 120 micro molar DCIP. Reactions are initiated by addition of enzyme to a final concentration in the range of about 5 nM to about 50 nM while maintaining the temperature of a circulating water bath at 25° C. Alternatively, for potent compounds, activity was determined by directly measuring the production of orotic acid at 296 nm (ε = 4.3 mM-1 cm-1). | ChEMBL. | No reference |
| IC50 (functional) | = 1241 nM | MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | = 15.8758726119995 uM | MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | = 22.8994560241699 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 (functional) | = 22.899456024169922 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. | ChEMBL. | No reference |
| IC50 (functional) | > 32 uM | MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. | ChEMBL. | No reference |
| IC50 | > 32 uM | MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. | ChEMBL. | No reference |
| IC50 (functional) | > 32 uM | MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). | ChEMBL. | No reference |
| Inhibition (functional) | = -44.7751310373617 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = -5.54056131455081 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = -5.540561314550807 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 1.18 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| Inhibition (functional) | = 2 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM | ChEMBL. | 20485427 |
| Inhibition (functional) | = 2 % | GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM. | ChEMBL. | 20485427 |
| Inhibition (functional) | = 2.47 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| Inhibition (functional) | = 4.308240273042956 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = 4.30824027304296 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = 4.53 % | MMV: Screen against Mtb, single point, non replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 6.65 % | ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| Inhibition (functional) | = 17.1499966896032 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 19.5 % | MMV: Screen against Mtb, single point, replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 23 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 72 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 97 % | GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
| Inhibition (functional) | = 98 % | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM | ChEMBL. | 20485427 |
| Inhibition (functional) | = 98 % | MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. | ChEMBL. | No reference |
| Inhibition frequency index (IFI) (functional) | = 0 | Inhibition Frequency Index (IFI) | GSK. | 20485427 |
| IZ | = 0 mm | MMV: Selection for compounds that exhibit enhanced toxicity in combination with artemisinin. Assay utilized the disc diffusion method with the observance of a clear zone indicating inhibition of growth. Synthetic complete medium containing 3% glycerol as a carbon source (SCG) was used in each assay. 10 uL of each compound was added to a paper disc which was placed on SCG and SCG+Artemisinin (0.2 uM) plates seeded with 10e6 yeast cells (WC081 strain: Mat a, leu2 delta 0, lys2 delta 0, ura3 delta 0, his3 delta 1, pdr1 delta::HIS3, pdr3 delta::kanMX4, derived from BY4742, regulators of Multi-drug resistance transporters have been deleted to enhance toxicity of compounds). Plates were incubated at 30 degrees C for 5 days and clear zones were measured. Compounds that produced a larger clear zone in the presence of artemisinin was considered to have an additive interaction with artemisinin. Results are reported as diameter of clear zone on SCG+artemisinin plates - diameter of clear zone on SCG plates without artemisinin. | ChEMBL. | No reference |
| Percent growth inhibition (functional) | = 2 % | Percent inhibition of HepG2 growth (at 10 uM) | GSK. | 20485427 |
| Percent growth inhibition (functional) | = 2 % | Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM) | GSK. | 20485427 |
| Percent growth inhibition (functional) | = 97 % | Percent inhibition of P. falciparum Dd2 growth (at 2 uM) | GSK. | 20485427 |
| Percent growth inhibition (functional) | = 98 % | Percent inhibition of P. falciparum 3D7 growth (at 2 uM) | GSK. | 20485427 |
| Ratio (functional) | = 0.662790697674419 | MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.6431 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.0311 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = 0.1169 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Toxicity (functional) | = 0 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 0 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 0 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| XC50 (functional) | = 7.8 | XC50 determination of P. falciparum 3D7 growth | GSK. | 20485427 |
| XC50 (functional) | = 0.0158 uM | GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth. | ChEMBL. | 20485427 |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Trypanosoma brucei gambiense | |||
| Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
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In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
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In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.
External resources for this compound
- ChEMBL: CHEMBL546168
- Search by GSK
Bibliographic References
1 literature reference was collected for this gene.
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