Detailed information for compound 604311
Basic information
Technical information
- TDR Targets ID: 604311
- Name: 1-carbazol-9-yl-3-(3-methylbutylamino)propan- 2-ol hydrochloride
- MW: 346.894 | Formula: C20H27ClN2O
-
H donors: 2
H acceptors: 1
LogP: 4.71
Rotable bonds: 7
Rule of 5 violations (Lipinski): 1 - SMILES: OC(Cn1c2ccccc2c2c1cccc2)CNCCC(C)C.Cl
- InChi: 1S/C20H26N2O.ClH/c1-15(2)11-12-21-13-16(23)14-22-19-9-5-3-7-17(19)18-8-4-6-10-20(18)22;/h3-10,15-16,21,23H,11-14H2,1-2H3;1H
- InChiKey: QYDVLRAVLYMEEV-UHFFFAOYSA-N
Network
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Synonyms
- 1-carbazol-9-yl-3-(isopentylamino)propan-2-ol hydrochloride
- 1-(9-carbazolyl)-3-(isopentylamino)propan-2-ol hydrochloride
- 1-carbazol-9-yl-3-(isoamylamino)propan-2-ol hydrochloride
Targets
Known targets for this compound
| Species | Target name | Source | Bibliographic reference |
|---|---|---|---|
| Plasmodium falciparum | protein kinase 7 | Starlite/ChEMBL | No references |
| Leishmania mexicana | glucose transporter, lmgt2 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | protein kinase 6 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | Starlite/ChEMBL | No references |
| Homo sapiens | solute carrier family 2 (facilitated glucose transporter), member 1 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | lysine--tRNA ligase | Starlite/ChEMBL | No references |
| Plasmodium falciparum | hexose transporter | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Proline--tRNA ligase | Starlite/ChEMBL | No references |
| Plasmodium falciparum (isolate 3D7) | Calcium-dependent protein kinase 4 | Starlite/ChEMBL | No references |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | Starlite/ChEMBL | No references |
Predicted pathogen targets for this compound
By orthology
By sequence similarity to non orthologous known druggable targets
Obtained from network model
Ranking Plot
Putative Targets List
| Species | Potential target | Raw | Global | Species |
|---|---|---|---|---|
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.0347 | 0.2646 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.0595 | 0.1973 |
| Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0387 | 0.0674 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.019 | 0.0326 |
| Echinococcus granulosus | General substrate transporter | 0.0108 | 0.1906 | 0.335 |
| Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0021 | 0.0256 | 0.0443 |
| Schistosoma mansoni | glucose transporter | 0.0018 | 0.019 | 0.0326 |
| Toxoplasma gondii | LsmAD domain-containing protein | 0.0052 | 0.0842 | 0.1154 |
| Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0848 | 0.3207 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Leishmania major | myo-inositol/proton symporter (MIT) | 0.0018 | 0.019 | 0.0238 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.019 | 0.0828 |
| Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.0848 | 0.4503 |
| Trypanosoma brucei | PAB1-binding protein , putative | 0.0052 | 0.0842 | 0.4911 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0842 | 0.1475 |
| Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.0809 | 1 |
| Mycobacterium ulcerans | fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT | 0.0018 | 0.019 | 0.145 |
| Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.2062 | 0.3625 |
| Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.131 | 0.1873 |
| Schistosoma mansoni | kinase | 0.0051 | 0.0817 | 0.1431 |
| Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0053 | 0.0848 | 0.4503 |
| Toxoplasma gondii | prolyl-tRNA synthetase (ProRS) | 0.0044 | 0.0689 | 0.092 |
| Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0256 | 0.0104 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.0318 | 0.2426 |
| Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.0312 | 0.0541 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0793 | 0.2941 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0097 | 0.1696 | 0.298 |
| Schistosoma mansoni | hypothetical protein | 0.0308 | 0.5679 | 1 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0689 | 0.3474 |
| Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0097 | 0.1696 | 1 |
| Plasmodium falciparum | calcium-dependent protein kinase 1 | 0.0039 | 0.06 | 0.0454 |
| Toxoplasma gondii | sugar transporter ST3 | 0.0018 | 0.019 | 0.0155 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0241 | 0.2975 |
| Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0256 | 0.142 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.019 | 0.0828 |
| Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0347 | 0.2646 |
| Plasmodium falciparum | calcium-dependent protein kinase 4 | 0.0039 | 0.06 | 0.0454 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.019 | 0.0326 |
| Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0099 |
| Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0297 | 0.0521 |
| Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0664 |
| Trypanosoma brucei | glucose transporter 2A | 0.0039 | 0.0595 | 0.3439 |
| Trypanosoma cruzi | prolyl-tRNA synthetase, putative | 0.0044 | 0.0689 | 0.3474 |
| Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0077 | 0.131 | 0.1873 |
| Brugia malayi | Bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0571 | 0.2529 |
| Mycobacterium leprae | ATP-dependent Clp protease proteolytic subunit 1 | 0.0027 | 0.0356 | 0.2717 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Loa Loa (eye worm) | acyl carrier protein | 0.0011 | 0.0068 | 0.0111 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0039 | 0.06 | 0.1997 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Mycobacterium ulcerans | polyketide synthase | 0.0025 | 0.0318 | 0.2426 |
| Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0118 | 0.1458 |
| Brugia malayi | hypothetical protein | 0.0052 | 0.0842 | 0.3742 |
| Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 1 |
| Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0153 | 0.0809 |
| Brugia malayi | Sugar transporter family protein | 0.0018 | 0.019 | 0.0828 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2241 | 0.3942 |
| Echinococcus granulosus | mitogen activated protein kinase | 0.0053 | 0.0848 | 0.1486 |
| Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0077 | 0.131 | 1 |
| Onchocerca volvulus | 0.0043 | 0.0661 | 0.3128 | |
| Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.0347 | 0.2646 |
| Mycobacterium leprae | Possible lysyl-tRNA synthetase 2 LysX | 0.0028 | 0.0387 | 0.2955 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Trypanosoma brucei | lysyl-tRNA synthetase, putative | 0.0028 | 0.0387 | 0.2202 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0848 | 0.3207 |
| Schistosoma mansoni | ran | 0.0021 | 0.0256 | 0.0443 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0571 | 0.0997 |
| Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0024 | 0.0304 | 0.3755 |
| Mycobacterium ulcerans | sugar-transport integral membrane protein SugI | 0.0018 | 0.019 | 0.145 |
| Plasmodium vivax | mitogen-activated protein kinase 2, putative | 0.0205 | 0.3726 | 0.3628 |
| Schistosoma mansoni | hypothetical protein | 0.0126 | 0.2241 | 0.3942 |
| Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0097 | 0.1696 | 1 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Schistosoma mansoni | nuclear transcription factor X-box binding 1 (nfx1) | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0307 | 0.3794 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0018 | 0.019 | 0.0238 |
| Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0097 | 0.1696 | 1 |
| Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 0.1175 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Toxoplasma gondii | protein kinase, putative | 0.0357 | 0.6613 | 1 |
| Toxoplasma gondii | cell-cycle-associated protein kinase MAPK, putative | 0.0205 | 0.3726 | 0.5575 |
| Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.04 | 0.0696 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.019 | 0.0828 |
| Plasmodium falciparum | importin beta, putative | 0.0029 | 0.04 | 0.025 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.0733 | 0.3255 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 1 |
| Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0025 | 0.0318 | 0.2426 |
| Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0297 | 0.0521 |
| Plasmodium falciparum | lysine--tRNA ligase | 0.0028 | 0.0387 | 0.0237 |
| Loa Loa (eye worm) | sugar transporter | 0.0018 | 0.019 | 0.0326 |
| Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0097 | 0.1696 | 0.7561 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Mycobacterium leprae | Probable prolyl tRNA synthetase ProS | 0.0038 | 0.0571 | 0.4354 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium leprae | Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) | 0.0024 | 0.0307 | 0.2342 |
| Echinococcus granulosus | calcium dependent protein kinase | 0.0036 | 0.054 | 0.0943 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.06 | 0.1048 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Toxoplasma gondii | lysine-tRNA ligase | 0.0028 | 0.0387 | 0.0458 |
| Echinococcus multilocularis | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0571 | 0.0997 |
| Mycobacterium ulcerans | thioesterase | 0.002 | 0.0241 | 0.1836 |
| Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.0809 | 0.1417 |
| Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.002 | 0.0227 | 0.1735 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0053 | 0.0848 | 0.1486 |
| Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0053 | 0.0848 | 0.4948 |
| Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Leishmania major | protein kinase, putative | 0.0039 | 0.06 | 0.2893 |
| Toxoplasma gondii | hypothetical protein | 0.0027 | 0.0356 | 0.041 |
| Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.1696 | 1 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.0595 | 0.2861 |
| Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0025 | 0.0318 | 0.2426 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Plasmodium vivax | sugar transporter, putative | 0.0018 | 0.019 | 0.0037 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.019 | 0.0828 |
| Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 1 |
| Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0025 | 0.0318 | 0.14 |
| Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0287 | 0.3554 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.005 | 0.0793 | 0.2941 |
| Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0153 | 0.1896 |
| Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0037 | 0.0547 | 0.6765 |
| Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0387 | 0.0911 |
| Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0039 | 0.06 | 0.1048 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.0184 | 0.0147 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.019 | 0.0828 |
| Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0008 | 0.0014 | 0.017 |
| Brugia malayi | lysyl-tRNA synthetase | 0.0028 | 0.0387 | 0.171 |
| Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.0809 | 0.1417 |
| Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.0318 | 0.2426 |
| Mycobacterium tuberculosis | Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) | 0.0018 | 0.019 | 0.235 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0595 | 0.1973 |
| Mycobacterium tuberculosis | Probable conserved integral membrane transport protein | 0.0018 | 0.019 | 0.235 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.06 | 0.2387 |
| Trypanosoma brucei | bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0689 | 0.4002 |
| Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0664 |
| Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.0809 | 1 |
| Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0021 | 0.0256 | 0.0256 |
| Leishmania major | hypothetical protein, conserved | 0.0052 | 0.0842 | 0.4463 |
| Plasmodium falciparum | calcium-dependent protein kinase 3 | 0.0039 | 0.06 | 0.0454 |
| Echinococcus granulosus | lysyl tRNA synthetase | 0.0028 | 0.0387 | 0.0674 |
| Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0053 | 0.0848 | 0.4503 |
| Trypanosoma brucei | glucose transporter 1E | 0.0039 | 0.0595 | 0.3439 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.0595 | 0.1973 |
| Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0024 | 0.0304 | 0.3755 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.019 | 0.0828 |
| Leishmania major | glucose transporter, lmgt3 | 0.0039 | 0.0595 | 0.2861 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK3 | 0.0039 | 0.06 | 0.0784 |
| Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.04 | 0.025 |
| Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 1 |
| Plasmodium vivax | proline--tRNA ligase, putative | 0.0044 | 0.0689 | 0.0544 |
| Plasmodium falciparum | major facilitator superfamily domain-containing protein, putative | 0.0018 | 0.019 | 0.0037 |
| Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0097 | 0.1696 | 0.298 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0571 | 0.0997 |
| Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0256 | 0.0665 |
| Schistosoma mansoni | importin beta-1 | 0.0029 | 0.04 | 0.0696 |
| Echinococcus multilocularis | synaptic vesicle 2 protein | 0.0018 | 0.019 | 0.0326 |
| Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0297 | 0.0521 |
| Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0356 | 0.2067 |
| Plasmodium vivax | calcium-dependent protein kinase 1, putative | 0.0039 | 0.06 | 0.0454 |
| Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 0.2301 |
| Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0025 | 0.0318 | 0.3931 |
| Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.0318 | 0.2426 |
| Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.1406 | 0.6264 |
| Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0023 | 0.0297 | 0.0515 |
| Plasmodium vivax | calcium-dependent protein kinase, putative | 0.0039 | 0.06 | 0.0454 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0025 | 0.0318 | 0.2426 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.06 | 0.1048 |
| Trypanosoma cruzi | sugar transporter, putative | 0.0018 | 0.019 | 0.0238 |
| Leishmania major | GTP-binding protein, putative | 0.0021 | 0.0256 | 0.0665 |
| Onchocerca volvulus | 0.0023 | 0.0287 | 0.0647 | |
| Plasmodium vivax | calcium-dependent protein kinase 4, putative | 0.0039 | 0.06 | 0.0454 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0016 | 0.0161 | 0.1228 |
| Giardia lamblia | Kinase, PLK | 0.0097 | 0.1696 | 1 |
| Trypanosoma cruzi | lysyl-tRNA synthetase, putative | 0.0028 | 0.0387 | 0.1516 |
| Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0297 | 0.0515 |
| Mycobacterium ulcerans | prolyl-tRNA synthetase | 0.0013 | 0.0107 | 0.0819 |
| Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0256 | 0.0438 |
| Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0347 | 0.4287 |
| Echinococcus granulosus | glutamyl tRNA synthetase cytoplasmic | 0.0038 | 0.0571 | 0.0997 |
| Brugia malayi | hypothetical protein | 0.0034 | 0.0492 | 0.2177 |
| Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0633 | 0.1107 |
| Trypanosoma cruzi | polo-like protein kinase, putative | 0.0097 | 0.1696 | 1 |
| Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0025 | 0.0318 | 0.3931 |
| Brugia malayi | major facilitator superfamily protein | 0.0018 | 0.019 | 0.0828 |
| Echinococcus multilocularis | calcium dependent protein kinase | 0.0036 | 0.054 | 0.0943 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0848 | 0.3207 |
| Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 1 |
| Plasmodium falciparum | proline--tRNA ligase | 0.0044 | 0.0689 | 0.0544 |
| Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0256 | 0.1123 |
| Echinococcus multilocularis | General substrate transporter | 0.0108 | 0.1906 | 0.335 |
| Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.0287 | 0.0498 |
| Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0842 | 0.0699 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0039 | 0.06 | 0.266 |
| Leishmania major | glucose transporter, lmgt1 | 0.0039 | 0.0595 | 0.2861 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.0387 | 0.2955 |
| Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0155 | 0.0102 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Schistosoma mansoni | protein kinase | 0.0039 | 0.06 | 0.1048 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0021 | 0.0259 | 0.0685 |
| Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0077 | 0.131 | 0.2301 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Trypanosoma cruzi | glucose transporter, putative | 0.0018 | 0.019 | 0.0238 |
| Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0039 | 0.06 | 0.1048 |
| Leishmania major | glucose transporter/membrane transporter D2, putative | 0.0039 | 0.0595 | 0.2861 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Echinococcus multilocularis | mitogen activated protein kinase | 0.0053 | 0.0848 | 0.1486 |
| Giardia lamblia | Lysyl-tRNA synthetase | 0.0028 | 0.0387 | 0.1309 |
| Brugia malayi | Major Facilitator Superfamily protein | 0.0018 | 0.019 | 0.0828 |
| Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0023 | 0.0297 | 0.0515 |
| Trypanosoma cruzi | GTP-binding nuclear protein rtb2, putative | 0.0021 | 0.0256 | 0.0665 |
| Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.06 | 0.1048 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0126 | 0.2241 | 0.33 |
| Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0021 | 0.0256 | 0.0443 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.04 | 0.0696 |
| Trichomonas vaginalis | CMGC family protein kinase | 0.0053 | 0.0848 | 0.3207 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0097 | 0.1696 | 0.298 |
| Echinococcus multilocularis | snurportin 1 | 0.0308 | 0.5679 | 1 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.019 | 0.0326 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.0595 | 0.2861 |
| Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0053 | 0.0848 | 0.1486 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0025 | 0.0322 | 0.0641 |
| Plasmodium falciparum | calcium-dependent protein kinase 2 | 0.0039 | 0.06 | 0.0454 |
| Toxoplasma gondii | sugar transporter ST2 | 0.0018 | 0.019 | 0.0155 |
| Brugia malayi | MAP kinase sur-1 | 0.0053 | 0.0848 | 0.377 |
| Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0287 | 0.1264 |
| Brugia malayi | Cam kinase protein 1 | 0.0039 | 0.06 | 0.266 |
| Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0016 | 0.0148 | 0.0253 |
| Leishmania major | hypothetical protein, conserved | 0.0018 | 0.019 | 0.0238 |
| Mycobacterium ulcerans | integral membrane transport protein | 0.0018 | 0.019 | 0.145 |
| Toxoplasma gondii | transporter, major facilitator family protein | 0.0018 | 0.019 | 0.0155 |
| Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0053 | 0.0848 | 0.1486 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Plasmodium falciparum | protein kinase 7 | 0.0357 | 0.6613 | 0.656 |
| Schistosoma mansoni | glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) | 0.0038 | 0.0571 | 0.0997 |
| Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0025 | 0.0318 | 0.3931 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0595 | 0.1973 |
| Trichomonas vaginalis | CAMK family protein kinase | 0.0097 | 0.1696 | 0.7341 |
| Giardia lamblia | Prolyl-tRNA synthetase | 0.0038 | 0.0571 | 0.2527 |
| Plasmodium falciparum | mitogen-activated protein kinase 2 | 0.0205 | 0.3726 | 0.3628 |
| Brugia malayi | Sugar transporter family protein | 0.0126 | 0.2241 | 1 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Echinococcus granulosus | Sugar transporter ERD6 protein | 0.0018 | 0.019 | 0.0326 |
| Trypanosoma brucei | calcium/calmodulin-dependent protein kinase, putative | 0.0039 | 0.06 | 0.3468 |
| Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0297 | 0.093 |
| Trichomonas vaginalis | prolyl-tRNA synthetase, putative | 0.0038 | 0.0571 | 0.1855 |
| Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0842 | 0.4463 |
| Brugia malayi | MH2 domain containing protein | 0.0117 | 0.2062 | 0.9197 |
| Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.002 | 0.0227 | 0.1735 |
| Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0053 | 0.0848 | 0.4503 |
| Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0308 | 0.5679 | 1 |
| Leishmania major | lysyl-tRNA synthetase, putative | 0.0028 | 0.0387 | 0.1516 |
| Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0153 | 0.0262 |
| Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.002 | 0.0227 | 0.1735 |
| Trichomonas vaginalis | conserved hypothetical protein | 0.0126 | 0.2241 | 1 |
| Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0099 |
| Brugia malayi | Importin beta-1 subunit | 0.0029 | 0.04 | 0.1767 |
| Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.0595 | 0.1973 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.001 | 0.0042 | 0.0517 |
| Plasmodium vivax | calcium-dependent protein kinase 3, putative | 0.0039 | 0.06 | 0.0454 |
| Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.04 | 0.2279 |
| Echinococcus multilocularis | Sugar transporter ERD6 protein | 0.0018 | 0.019 | 0.0326 |
| Trypanosoma brucei | glucose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.131 | 0.2301 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0039 | 0.06 | 0.1048 |
| Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0037 | 0.0547 | 0.4175 |
| Trypanosoma cruzi | hexose transporter | 0.0039 | 0.0595 | 0.2861 |
| Plasmodium vivax | lysine--tRNA ligase, putative | 0.0028 | 0.0387 | 0.0237 |
| Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0241 | 0.1836 |
| Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0114 | 0.0193 |
| Onchocerca volvulus | Fatty acid synthase homolog | 0.0044 | 0.069 | 0.332 |
| Giardia lamblia | Kinase, CMGC MAPK | 0.0053 | 0.0848 | 0.4369 |
| Schistosoma mansoni | sugar transporter | 0.0018 | 0.019 | 0.0326 |
| Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0027 | 0.0356 | 0.0206 |
| Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0037 | 0.0547 | 0.6765 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0689 | 0.3474 |
| Echinococcus granulosus | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.019 | 0.0326 |
| Loa Loa (eye worm) | major facilitator superfamily transporter | 0.0018 | 0.019 | 0.0326 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Schistosoma mansoni | serine/threonine protein kinase | 0.0097 | 0.1696 | 0.298 |
| Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0233 | 0.2886 |
| Trypanosoma cruzi | hexose transporter, putative | 0.0039 | 0.0595 | 0.2861 |
| Trypanosoma brucei | polo-like protein kinase | 0.0097 | 0.1696 | 1 |
| Trichomonas vaginalis | ran, putative | 0.0021 | 0.0256 | 0.0321 |
| Mycobacterium leprae | Polyketide synthase Pks13 | 0.0037 | 0.0547 | 0.4175 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0039 | 0.06 | 0.1048 |
| Brugia malayi | Probable ClpP-like protease | 0.0077 | 0.131 | 0.5837 |
| Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0571 | 0.0997 |
| Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0039 | 0.06 | 0.1048 |
| Plasmodium vivax | hexose transporter | 0.0126 | 0.2241 | 0.2121 |
| Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.0347 | 0.4287 |
| Entamoeba histolytica | hypothetical protein | 0.0023 | 0.0297 | 0.0284 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2A | 0.0039 | 0.06 | 0.0784 |
| Entamoeba histolytica | prolyl-tRNA synthetase, putative | 0.0038 | 0.0571 | 0.2185 |
| Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0053 | 0.0848 | 0.4503 |
| Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0038 | 0.0571 | 0.2529 |
| Plasmodium vivax | ataxin-2 like protein, putative | 0.0052 | 0.0842 | 0.0699 |
| Trypanosoma brucei | sugar transporter, putative | 0.0018 | 0.019 | 0.1028 |
| Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0021 | 0.0256 | 0.0443 |
| Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0126 | 0.2241 | 0.3942 |
| Echinococcus multilocularis | lysyl tRNA synthetase | 0.0028 | 0.0387 | 0.0674 |
| Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0053 | 0.0848 | 0.1486 |
| Trypanosoma brucei | protein kinase, putative | 0.0053 | 0.0848 | 0.4948 |
| Leishmania major | prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative | 0.0044 | 0.0689 | 0.3474 |
| Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0241 | 0.1836 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Mycobacterium ulcerans | lysyl-tRNA synthetase | 0.0028 | 0.0387 | 0.2955 |
| Plasmodium falciparum | ataxin-2 like protein, putative | 0.0052 | 0.0842 | 0.0699 |
| Echinococcus multilocularis | solute carrier family 22 | 0.0018 | 0.019 | 0.0326 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2241 | 0.3942 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Toxoplasma gondii | calcium-dependent protein kinase CDPK2B | 0.0039 | 0.06 | 0.0784 |
| Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.0347 | 0.2646 |
| Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0053 | 0.0848 | 0.4503 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium ulcerans | sugar transporter | 0.0018 | 0.019 | 0.145 |
| Leishmania major | glucose transporter, lmgt2 | 0.0039 | 0.0595 | 0.2861 |
| Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0016 | 0.0161 | 0.1228 |
| Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.0347 | 0.2646 |
| Schistosoma mansoni | peptidase Clp (S14 family) | 0.0077 | 0.131 | 0.2301 |
| Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0053 | 0.0848 | 0.1164 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Trypanosoma cruzi | PAB1-binding protein , putative | 0.0052 | 0.0842 | 0.4463 |
| Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0021 | 0.0256 | 0.0104 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.0387 | 0.0674 |
| Echinococcus granulosus | snurportin 1 | 0.0308 | 0.5679 | 1 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Entamoeba histolytica | protein kinase, putative | 0.0039 | 0.06 | 0.2387 |
| Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.019 | 0.0326 |
| Toxoplasma gondii | sugar transporter ST1 | 0.0018 | 0.019 | 0.0155 |
| Trichomonas vaginalis | lysyl-tRNA synthetase, putative | 0.0028 | 0.0387 | 0.0961 |
| Trypanosoma brucei | myo-inositol/proton symporter (MIT) | 0.0018 | 0.019 | 0.1028 |
| Schistosoma mansoni | lysyl-tRNA synthetase | 0.0028 | 0.0387 | 0.0674 |
| Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0436 | 0.076 |
| Trichomonas vaginalis | sugar transporter, putative | 0.0039 | 0.0595 | 0.1973 |
| Trypanosoma brucei | THT1 - hexose transporter, putative | 0.0039 | 0.0595 | 0.3439 |
| Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0018 | 0.0187 | 0.2317 |
| Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0153 | 0.0262 |
| Trichomonas vaginalis | glucose transporter, putative | 0.0039 | 0.0595 | 0.1973 |
| Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.005 | 0.0809 | 0.6172 |
| Loa Loa (eye worm) | sugar transporter | 0.0126 | 0.2241 | 0.3942 |
| Echinococcus granulosus | synaptic vesicle 2 protein | 0.0018 | 0.019 | 0.0326 |
| Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0016 | 0.0161 | 0.1228 |
| Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0297 | 0.093 |
| Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.04 | 0.0477 |
| Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.0347 | 0.2646 |
| Mycobacterium tuberculosis | Lysyl-tRNA synthetase 2 LysX | 0.0024 | 0.0307 | 0.3794 |
| Brugia malayi | hypothetical protein | 0.0018 | 0.019 | 0.0828 |
| Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.0347 | 0.4287 |
| Plasmodium falciparum | hexose transporter | 0.0126 | 0.2241 | 0.2121 |
| Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0077 | 0.131 | 0.1175 |
| Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0153 | 0.0809 |
| Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.04 | 0.0696 |
| Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.0347 | 0.0396 |
| Schistosoma mansoni | glucose transport protein | 0.0126 | 0.2241 | 0.3942 |
| Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0027 | 0.0356 | 0.0206 |
| Schistosoma mansoni | ran | 0.0021 | 0.0256 | 0.0443 |
| Plasmodium vivax | CDK-related protein kinase 6, putative | 0.0536 | 1 | 1 |
| Plasmodium falciparum | calcium-dependent protein kinase 5 | 0.0039 | 0.06 | 0.0454 |
| Chlamydia trachomatis | lysine--tRNA ligase | 0.0028 | 0.0387 | 0.2326 |
| Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.04 | 0.2279 |
| Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.2062 | 0.3625 |
Activities
| Activity type | Activity value | Assay description | Source | Reference |
|---|---|---|---|---|
| Activity (functional) | NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction in Plasmodium yoelii schizont area in HepG2-A16-CD81 cells at 10uM compound concentration, determined by immuno-fluorescence. | ChEMBL. | 22096101 | |
| CC50 (functional) | = 8.06 uM | Huh7 cytotoxicity for Pf inhibitors | Novartis-GNF Malaria Box. | No reference |
| CC50 | = 8.06 uM | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | ChEMBL. | 18579783 |
| EC50 (functional) | = 210 nM | MMV: Inhibition of Plasmodium falciparum K1 (EC50). | ChEMBL. | No reference |
| EC50 (functional) | = 473 nM | MMV: Inhibition of Plasmodium falciparum 3D7 (EC50). | ChEMBL. | No reference |
| EC50 (functional) | = 0.0323 uM | W2 Pf proliferation inhibition | Novartis-GNF Malaria Box. | No reference |
| EC50 (functional) | = 0.0323 uM | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
| EC50 (functional) | = 0.2009 uM | PF proliferation inhibition 3D7 | Novartis-GNF Malaria Box. | No reference |
| EC50 (functional) | = 0.2009 uM | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | ChEMBL. | 18579783 |
| Growth Inhibition (functional) | = 62.6796 % | MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. | ChEMBL. | No reference |
| IC50 (functional) | = 906.6 nM | MMV: IC50 determined against P. falciparum Dd2-luc strain using a Malaria Sybr Green I Fluorescence assay. Starting conditions were 1% trophozoite synchronised parasites at 2% haematocrit. Fluorescence detection completed after 48hr incubation at 37 degrees C under 1% O2, 3% CO2 and balance N2. | ChEMBL. | No reference |
| IC50 (functional) | = 2825.816667 nM | MMV: Measure of pLDH activity as indication of parasite viability. Gametocytogenesis of 3D7 Plasmodium falciparum strain was induced in vitro and asexual parasites were depleted with N-acetylglucosamine. Gametocytes were treated with dihydroartemisinin, epoxomicin, methylene blue, primaquine, puromycin or chloroquine in 96-well plates and the pLDH activity was evaluated using a modified Makler protocol. Mosquito infectivity was measured by the standard membrane feeding assay. The IC50 value was extrapolated as the concentration that induced a 50% inhibition of gametocyte viability. | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | > 12000 nM | ST_JUDE_LEISH: Cytotoxicity against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro | ChEMBL. | No reference |
| IC50 (functional) | = 0.930805563926697 uM | MMV: Inhibition of Trypanosoma brucei brucei (Squib 427) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: MAP2K Protein kinase inhibition assay using recombinant PfMAP2K, protein substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 0.5 mM DTT, 1 mM MgCl2, 0.5 mg/mL BSA, and 10 ug/ml MAP2 in a buffer of 50 mM HEPES (pH 7.0). 0.5 mg/mL histone III-S served as the substrate (13); 100 uM AMP-PNP, an ATP analog, was used as a control inhibitor. Incubation time was 4 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK6 Protein kinase inhibition assay using recombinant PfPK6, Myelin Basic Protein (MBP) substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1.5 uM ATP, 5 mM MnCl2, and 15 ug/ml PK6 in a buffer of 100 mM Tris-HCl (pH 7.5). 50 ug/mL MBP was provided as the substrate; 10 uM staurosporine was used as a control inhibitor. Incubation time was 3 hours and 40 minutes.The catalytic activity of each kinase was considered proportional to ATP consumed, as determined from measurements of residual [ATP] with the luciferase-based reagent Kinase-Glo (Promega) following incubation. Luminescence (proportional to residual [ATP]) was measured on the plate readers FLx800 (BioTek Instruments, Winooski, VT, USA) and MicroBeta2. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK1 Protein kinase inhibition assay using recombinant PfCDPK1, syntide 2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: PK7 Protein kinase inhibition assay using recombinant PfPK7, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. Final concentrations were 1 uM ATP, 2 mM DTT, 20 mM MgCl2, 2 mM MnCl2, 0.01% BSA, and 6 ug/ml PK7, in a buffer of 20 mM Tris-HCl (pH 7.5). The enzyme itself was the only substrate present (since autophosphorylation occurs); 100 uM 1NA-PP1 was used as a control inhibitor. Incubation time was 3 hours. | ChEMBL. | No reference |
| IC50 (functional) | > 1 uM | MMV: CDPK4 Protein kinase inhibition assay using recombinant PfCDPK4, syntide2 peptide substrate, ATP and KinaseGlo to measure % inhibition at 1 uM MMV box compound. | ChEMBL. | No reference |
| IC50 (functional) | = 1 uM | MMV: Inhibition of Trypanosoma brucei rhodesiense (STIB 900) (HAT in vitro). | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: ProRS recombinant Plasmodium falciparum Prolyl-tRNA-synthetase, assay with yeast tRNA, ATP, and proline and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | > 2.5 uM | MMV: KRS recombinant Plasmodium falciparum Lysyl-tRNA-synthetase, assay with yeast tRNA, ATP, and lysine and 3 uM MMV malaria box compound, assay read out with kinase glo as % inhibition. | ChEMBL. | No reference |
| IC50 (functional) | = 4 uM | MMV: Inhibition of Leishmania infantum (MHOM/MA/BE/67) in vitro. | ChEMBL. | No reference |
| IC50 (functional) | = 6.727171421051025 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 (functional) | = 6.72717142105103 uM | MMV: Inhibition of Trypanosoma cruzi (Tulahuen C4 LacZ) (Chagas in vitro). | ChEMBL. | No reference |
| IC50 | = 16.227941513061523 uM | MMV: Cytotoxicity against human fibroblasts (MRC-5) cells. | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: Primary screening was performed with each compound at a 30 uM final concentration and in triplicate in sealed 96-well polystyrene microtiter plates. Parasite inocula (100 ul) comprising 20000 parasites/ml were added to each well and grown at 37 degrees C in a humidified atmosphere of 5% CO2 for 72 h. Positive controls consisted of metronidazole at 1 mg/ml. The growth of E. histolytica trophozoites in each well was determined microscopically by measuring the diameters of the confluent cells in drug-containing wells relative to those in the nega- tive-control wells. | ChEMBL. | No reference |
| IC50 (functional) | > 30 uM | MMV: A total of 100ul of inoculum was added to each well (parasite/cell ratio, ~10:1; final volume, 200 ul). Six hours after inoculation, nonadherent parasites were removed, and 100 ul of complete DMEM (1% penicillin-streptomycin, 3% FBS) supplemented with inhibitors at different concentrations (2-fold serial dilutions starting from 30 uM) was added to all except the negative-control wells. Positive controls, consisting of pyrimethamine (PYR) and sulfadiazine (SDZ) (20-mg/ml stocks in DMSO), were tested at a 2mg/ml final concentration. Each test was performed in triplicate. | ChEMBL. | No reference |
| IFI promiscuity index | = 0.01408 | IFI promiscuity index | Novartis-GNF Malaria Box. | No reference |
| Inhibition (functional) | = -12.8661801481528 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Female gamete formation was recorded 24 hr later by automated microscopy detection of surface labelling of female gametes with a Cy3-conjugated antibody reactive to Pfs25. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = -10.1358030691579 % | MMV: P. falciparum NF54 functionally mature Stage V gametocytes were incubated for 24 hr in the presence of the test compounds. Gamete formation was then triggered by addition of 2uM xantheurenic acid and temperature decrease to ~20C. Male gamete exflagellation was recorded and analysed by automated microscopy after 20 min. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 2 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 1.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 4.970309684518398 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 4.9703096845184 % | MMV: P. berghei-infected blood was withdrawn from mice by cardiac pucture before being immediately added to ookinete culture medium containing test compounds. 26 hr later, GFP-positive ookinetes were identified and counted by automated microscopy. All compounds were tested in 4 independent experiments and data presented here is the mean. | ChEMBL. | No reference |
| Inhibition (functional) | = 16.6 % | MMV: Screen against Mtb, single point, non replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 46.746502285561085 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = 46.7465022855611 % | MMV: Cryptosporidium parvum oocysts (Iowa Strain) were prepared for use by treatment with 10 mM HCl (37 degrees C, 10 min) followed by 2 mM sodium taurocholate in phosphate-buffered saline (PBS) with Ca2+ and Mg2+ (16 degrees C, 10 min) in order to stimulate excystation. The high-throughput screen was carried out by inoculating >90% confluent human ileocecal adenocarcinoma (HCT-8) cells (ATCC) with ~5.5 x 10^3 primed oocysts per well. Experimental compounds or DMSO (vehicle) were added three hours after infection, and cells were incubated for 48 hours. | ChEMBL. | No reference |
| Inhibition (functional) | = 61 % | MMV: Malaria Box compounds were tested for inhibition of the human ether a go-go related gene (hERG), Kv11.1 channel, using IonWorks 384-well patch clamp electrophysiology at 11.1uM (3 independent assay plates up to 12 cells per concentration). | ChEMBL. | No reference |
| Inhibition (functional) | = 83.6 % | MMV: Screen against Mtb, single point, replicating, at 25uM | ChEMBL. | No reference |
| Inhibition (functional) | = 97 % | MMV: Inhibition of Plasmodium falciparum 3D7 at 5uM compound concentration. | ChEMBL. | No reference |
| LD50 | = 4.74 uM | MMV: Cytotoxicity CRC and LD50 against HepG2 | ChEMBL. | No reference |
| MIC90 (functional) | = 22.9 uM | MMV: CRC and MIC90 against Mtb (replicating) | ChEMBL. | No reference |
| MIC90 (functional) | > 100 uM | MMV: CRC and MIC90 against Mtb (non replicating) | ChEMBL. | No reference |
| Ratio (functional) | = 0.924528301886792 | MMV: Compounds (1uM) were screened in a 72hr growth assay monitored by flow cytometry both in the presence and absence of supplemental isopentenyl pyrophosphate (IPP) 200uM. Compounds which fail to show anti-malarial activity when chemically rescued by IPP are therefore specific to the apicoplast. The values are expressed as the ratio of the corresponding activity with and without IPP, respectively. | ChEMBL. | No reference |
| Relative Growth (functional) | = -1.0262 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing ethanol and glycerol as carbon sources (Yeast Nitrogen Base, Ethanol, Glycerol; YNBEG). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 180 OD readings, corresponding to roughly 45 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.9987 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in rich media containing dextrose as a carbon source (Yeast Extract, Peptone, Dextrose; YPD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Relative Growth (functional) | = -0.9941 | MMV: Growth assays were conducted using the prototrophic S. cerevisiae strain JHY222. Each MMV compound (0.1 mM) was tested in minimal media containing dextrose as a carbon source (Yeast Nitrogen Base, Dextrose; YNBD). The growth rate in the presence of each MMV compound was calculated as follows: (i) the first 10 OD readings were averaged and subtracted from all OD readings of the corresponding curve to set the baseline of the growth curve to zero, and (ii) the area under the curve (AUC) was then calculated as the sum of all OD readings. AUC was calculated following 80 OD readings, corresponding to roughly 20 h of growth. A relative growth value was calculated as follows: AUC(DRUG) - AUC(DMSO)/AUC(DMSO); where AUC(DMSO) represents growth measured in a DMSO control well that was on the same microtiter plate of the drug-treated culture. A relative growth value near zero means the compound had little or no effect on growth, whereas a value near -1 means the compound strongly or completely inhibited growth. | ChEMBL. | No reference |
| Toxicity (functional) | = 2 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 24 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 4 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 48 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
| Toxicity (functional) | = 4 | MMV: Toxicity @ 2.5 uM to newly transformed Schistosoma mansoni somules after 72 h on a scale of 0 (none) - 4 (most) as judged visually: includes short descriptors of effects (PMID:19597541). Caffrey group UCSF. | ChEMBL. | No reference |
Phenotypes
Whole-cell/tissue/organism interactions
| Species name | Source | Reference | Is orphan |
|---|---|---|---|
| Trypanosoma brucei gambiense | |||
| Homo sapiens | ChEMBL23 | ||
| Plasmodium falciparum | ChEMBL23 | 18579783 | |
| Trypanosoma cruzi | ChEMBL23 | ||
| Leishmania infantum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Annotated phenotypes:
We have no manually annotated phenotypes for this drug.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by
drugs, or by genetic manipulation of cells (e.g. gene knockouts or
knockdowns) is manually curated from the literature. These
descriptions help to describe the potential of the target for drug
development. If no information is available for this gene or if the
information is incomplete, this may mean that i) the papers
containing this information either appeared after the curation
effort for this organism was carried out or they were inadvertently
missed by curators; or that ii) the curation effort for this
organism has not yet started.
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External resources for this compound
- ChEMBL: CHEMBL584235
- Search by Novartis-GNF Malaria Box
Bibliographic References
No literature references available for this target.
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