Detailed information for compound 611914

Basic information

Technical information
  • TDR Targets ID: 611914
  • Name: 6-ethylsulfanyl-3-pyridin-4-yl-[1,2,4]triazol o[3,4-f]pyridazine
  • MW: 257.314 | Formula: C12H11N5S
  • H donors: 0 H acceptors: 4 LogP: 1.54 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCSc1ccc2n(n1)c(nn2)c1ccncc1
  • InChi: 1S/C12H11N5S/c1-2-18-11-4-3-10-14-15-12(17(10)16-11)9-5-7-13-8-6-9/h3-8H,2H2,1H3
  • InChiKey: HFUKRKUCKOQLCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-ethylsulfanyl-3-(4-pyridyl)-[1,2,4]triazolo[3,4-f]pyridazine
  • 6-(ethylthio)-3-(4-pyridyl)-[1,2,4]triazolo[3,4-f]pyridazine
  • ZINC04327952

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0003 0.0002
Schistosoma mansoni neuropeptide receptor 0.0014 0.0035 0.0033
Treponema pallidum ribonuclease H (rnhA) 0.0034 0.0125 0.1028
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0186 0.0807 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0055 0.0177
Brugia malayi exodeoxyribonuclease III family protein 0.0033 0.012 0.1203
Brugia malayi neuropeptide F receptor 0.0014 0.0035 0.034
Leishmania major hypothetical protein, conserved 0.0186 0.0807 0.8194
Brugia malayi hypothetical protein 0.0014 0.0033 0.0319
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0014 0.0033 0.2156
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0018 0.0166
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0031
Schistosoma mansoni NAD dehydrogenase 0.0186 0.0807 0.0806
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Leishmania major cytochrome p450-like protein 0.0007 0.0002 0.0012
Echinococcus granulosus g protein coupled receptor 0.0014 0.0035 0.0111
Onchocerca volvulus 0.0014 0.0033 0.0319
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0014 0.0035 0.0033
Brugia malayi nuclear receptor NHR-67 0.0009 0.0011 0.0095
Echinococcus granulosus neuropeptide receptor 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0007 0.0003 0.0005
Onchocerca volvulus 0.0225 0.0985 1
Echinococcus granulosus DNA topoisomerase 2 alpha 0.004 0.0151 0.0498
Mycobacterium ulcerans DNA gyrase subunit B 0.0049 0.0193 0.0191
Mycobacterium tuberculosis Possible maturase 0.0014 0.0033 0.0034
Schistosoma mansoni neuropeptide receptor 0.0014 0.0035 0.0033
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.2231 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0002 0.0001
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0002 0.0012
Echinococcus multilocularis allatostatin A receptor 0.0014 0.0035 0.0111
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0007 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0126 0.0124
Trypanosoma brucei phospholipase A1, putative 0.0225 0.0985 0.3672
Brugia malayi putative neuropeptide receptor NPR1 0.0014 0.0035 0.034
Echinococcus granulosus jun protein 0.0026 0.009 0.0295
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0033 0.039
Echinococcus granulosus carboxylesterase 5A 0.0034 0.0126 0.0412
Brugia malayi Zinc knuckle family protein 0.0014 0.0033 0.0319
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0034 0.0126 0.0124
Onchocerca volvulus 0.0014 0.0035 0.034
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0014 0.0033 0.0319
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0251 0.025
Onchocerca volvulus Putative fad oxidoreductase 0.0186 0.0807 0.8194
Chlamydia trachomatis D-amino acid dehydrogenase 0.0186 0.0807 0.6669
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0015 0.0014
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Schistosoma mansoni hypothetical protein 0.0014 0.0033 0.0031
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0055 0.0053
Onchocerca volvulus 0.0014 0.0035 0.034
Brugia malayi hypothetical protein 0.0014 0.0033 0.0319
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0239 0.0237
Echinococcus granulosus dnaJ subfamily B 0.0402 0.1777 0.5887
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0135 0.0133
Onchocerca volvulus 0.0014 0.0035 0.034
Plasmodium falciparum DNA topoisomerase 2 0.004 0.0151 0.1246
Chlamydia trachomatis DNA gyrase subunit A 0.0275 0.1206 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0011 0.0031
Onchocerca volvulus 0.0021 0.0065 0.0646
Onchocerca volvulus 0.0014 0.0035 0.034
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0002 0.0012
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Onchocerca volvulus 0.0014 0.0035 0.034
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0002 0.0001
Schistosoma mansoni biogenic amine receptor 0.0014 0.0035 0.0033
Trypanosoma brucei ribonuclease H1 0.0034 0.0125 0.0462
Schistosoma mansoni alpha-1 adrenergic receptor 0.0014 0.0035 0.0033
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0057 0.0228 0.2303
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0017 0.0048 0.0045
Echinococcus multilocularis G protein coupled receptor 139 0.0014 0.0035 0.0111
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0035 0.0033
Mycobacterium ulcerans amidase 0.0008 0.0009 0.0006
Brugia malayi cDNA sequence BC016226 0.0186 0.0807 0.8194
Onchocerca volvulus 0.0014 0.0035 0.034
Schistosoma mansoni phosphoglucomutase 0.0034 0.0125 0.0124
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Onchocerca volvulus 0.0014 0.0033 0.0319
Loa Loa (eye worm) amidase 0.0008 0.0009 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0018 0.0016
Echinococcus multilocularis carboxylesterase 5A 0.0034 0.0126 0.0412
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0239 0.0237
Onchocerca volvulus 0.0014 0.0035 0.034
Onchocerca volvulus 0.0225 0.0985 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0002 0.0001
Leishmania major phospholipase A1, putative 0.0225 0.0985 1
Brugia malayi reverse transcriptase 0.0014 0.0033 0.0319
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0055 0.0543
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0033 0.012 0.0117
Loa Loa (eye worm) hypothetical protein 0.0186 0.0807 0.0806
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0135 0.889
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.004 0.0151 0.1526
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0186 0.0807 0.8194
Trypanosoma cruzi phospholipase A1, putative 0.0225 0.0985 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.012 0.0982
Leishmania major cytochrome p450-like protein 0.0007 0.0002 0.0012
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0007 0.0001 0.008
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0055 0.0177
Loa Loa (eye worm) hypothetical protein 0.0036 0.0135 0.0133
Echinococcus granulosus pangolin 0.0045 0.0174 0.0573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0055 0.0177
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0055 0.0177
Schistosoma mansoni ap endonuclease 0.0033 0.012 0.0118
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0015 0.0014
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Echinococcus granulosus g-protein coupled receptor 0.0014 0.0035 0.0111
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0135 0.0498
Onchocerca volvulus 0.0014 0.0035 0.034
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0055 0.0053
Schistosoma mansoni hypothetical protein 0.0134 0.0574 0.0573
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0011 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0003 0.0002
Toxoplasma gondii ribonuclease HI protein 0.0034 0.0125 0.1028
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0186 0.0807 0.8194
Schistosoma mansoni hypothetical protein 0.0402 0.1777 0.1776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0055 0.0543
Echinococcus granulosus geminin 0.0134 0.0574 0.1899
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0186 0.0807 0.0806
Echinococcus multilocularis protein pangolin J 0.0045 0.0174 0.0573
Brugia malayi Cytochrome P450 family protein 0.0007 0.0002 0.0012
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0135 0.0442
Brugia malayi hypothetical protein 0.001 0.0015 0.0143
Brugia malayi larval opioid receptor 0.0014 0.0035 0.034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0055 0.0177
Mycobacterium ulcerans DNA gyrase subunit A 0.0275 0.1206 0.1204
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0033 0.012 0.0442
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0055 0.0543
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0186 0.0807 0.8194
Brugia malayi steroid hormone receptor 0.0019 0.0055 0.0543
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0026 0.009 0.0295
Brugia malayi sulfakinin receptor protein 0.0014 0.0035 0.034
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0055 0.0543
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0014 0.0035 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0003 0.0002
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0033 0.012 0.0925
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Brugia malayi reverse transcriptase 0.0014 0.0033 0.0319
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0186 0.0807 0.3009
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0035 0.0111
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.001 0.0089
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.1777 0.5887
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus multilocularis dro:myosuppressin receptor 0.0014 0.0035 0.0111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0055 0.0177
Trypanosoma brucei ingi protein (ORF1) 0.0048 0.0186 0.0692
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0005
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0035 0.0111
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0143
Leishmania major ribonuclease H1, putative 0.0034 0.0125 0.1259
Echinococcus granulosus allatostatin A receptor 0.0014 0.0035 0.0111
Brugia malayi RNase H family protein 0.0034 0.0125 0.1259
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0037 0.0135 0.0501
Schistosoma mansoni fatty-acid amide hydrolase 0.0069 0.0282 0.0281
Echinococcus granulosus neuropeptide receptor 0.0014 0.0035 0.0111
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0186 0.0807 0.8194
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0055 0.0177
Leishmania major hypothetical protein, conserved 0.0186 0.0807 0.8194
Brugia malayi nuclear receptor NHR-88 0.0019 0.0055 0.0543
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0014 0.0035 0.0111
Schistosoma mansoni nuclear receptor 0.0009 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Onchocerca volvulus 0.0028 0.0098 0.0985
Onchocerca volvulus 0.0009 0.0011 0.0095
Brugia malayi Tachykinin-like peptides receptor 99D 0.0014 0.0035 0.034
Echinococcus multilocularis orexin receptor type 2 0.0014 0.0035 0.0111
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0186 0.0807 0.8194
Echinococcus multilocularis cpg binding protein 0.003 0.0105 0.0345
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0186 0.0807 0.8194
Mycobacterium ulcerans amidase 0.0008 0.0009 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0055 0.0543
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0014 0.0035 0.0033
Trypanosoma cruzi ribonuclease H1, putative 0.0034 0.0125 0.1259
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0014 0.0035 0.0111
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0035 0.0131 0.1318
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0015 0.0047
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0007 0.0003 0.0005
Echinococcus granulosus 7tm_1 domain containing protein 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0033 0.012 0.0982
Onchocerca volvulus DNA topoisomerase 2 homolog 0.004 0.0151 0.1526
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0186 0.0807 0.8194
Echinococcus granulosus voltage gated potassium channel 0.001 0.0018 0.0054
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0002 0.0001
Echinococcus granulosus acetylcholinesterase 0.0034 0.0126 0.0412
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0033 0.012 0.0392
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0098 0.0097
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0003 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0035 0.0033
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0186 0.0807 0.3009
Echinococcus multilocularis 0.0007 0.0002 0.0004
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi hypothetical protein 0.0009 0.0011 0.0095
Brugia malayi Carboxylesterase family protein 0.0034 0.0126 0.1264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0035 0.0033
Schistosoma mansoni opsin-like receptor 0.0014 0.0035 0.0033
Brugia malayi hypothetical protein 0.001 0.0015 0.0143
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0186 0.0807 0.3009
Loa Loa (eye worm) platelet-activating factor acetylhydrolase 0.0225 0.0985 0.0984
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0003 0.0002
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi G protein-coupled receptor F59B2.13 0.0014 0.0035 0.034
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0214 0.0934 0.0933
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0002 0.0001
Trypanosoma cruzi DNA topoisomerase II, putative 0.0037 0.0135 0.1365
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0055 0.0543
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0186 0.0807 0.3009
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0186 0.0807 0.8194
Brugia malayi ecdysteroid receptor 0.0019 0.0055 0.0543
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.012 0.7898
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Schistosoma mansoni nuclear receptor 0.0009 0.0011 0.0009
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0014 0.0035 0.034
Onchocerca volvulus DNA topoisomerase 2 homolog 0.004 0.0151 0.1526
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0007 0.0003 0.0005
Schistosoma mansoni biogenic amine receptor 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0186 0.0807 0.0805
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0033 0.0104
Schistosoma mansoni opsin-like receptor 0.0014 0.0035 0.0033
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0014 0.0035 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0031
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0055 0.0177
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0055 0.0543
Brugia malayi G protein-coupled receptor 0.0014 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0011 0.0031
Trichomonas vaginalis Phospholipase C precursor, putative 0.0007 0.0001 0.008
Echinococcus multilocularis fmrfamide receptor 0.0014 0.0035 0.0111
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0014 0.0033 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0055 0.0543
Onchocerca volvulus 0.0225 0.0985 1
Brugia malayi hypothetical protein 0.0014 0.0033 0.0319
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0186 0.0692
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0002 0.001
Echinococcus granulosus dro:myosuppressin receptor 0.0014 0.0035 0.0111
Brugia malayi nuclear receptor NHR-88 0.0009 0.0011 0.0095
Brugia malayi Dopamine receptor 0.0014 0.0035 0.034
Brugia malayi putative amidase 0.0008 0.0009 0.0077
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0035 0.0033
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0014 0.0033 0.0031
Plasmodium falciparum DNA gyrase subunit A 0.0275 0.1206 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0007 0.0001 0.008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0055 0.0543
Echinococcus granulosus orexin receptor type 2 0.0014 0.0035 0.0111
Onchocerca volvulus 0.0014 0.0035 0.034
Plasmodium falciparum DNA gyrase subunit B 0.0049 0.0193 0.1594
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0002 0.0001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0055 0.0053
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus multilocularis neuropeptide s receptor 0.0466 0.2066 0.6844
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0014 0.0033 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0002 0.0001
Onchocerca volvulus 0.0014 0.0035 0.034
Schistosoma mansoni amine GPCR 0.0014 0.0035 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Brugia malayi hypothetical protein 0.0014 0.0033 0.0319
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0055 0.0543
Brugia malayi AKH receptor 0.0014 0.0035 0.034
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.0008 0.0009 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.0678 0.3018 0.3017
Echinococcus multilocularis geminin 0.0134 0.0574 0.1899
Chlamydia trachomatis DNA gyrase subunit B 0.0032 0.0117 0.0903
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0035 0.0033
Schistosoma mansoni hypothetical protein 0.0164 0.071 0.0709
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0002 0.0001
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0003 0.0005
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0251 0.0828
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Brugia malayi Zinc knuckle family protein 0.0014 0.0033 0.0319
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0035 0.0111
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0033 0.039
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0251 0.025
Brugia malayi Cytochrome P450 family protein 0.0007 0.0002 0.0012
Schistosoma mansoni neuropeptide f receptor 76f 0.0014 0.0035 0.0033
Trypanosoma cruzi amidase, putative 0.0008 0.0009 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0033 0.012 0.1203
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0014 0.0035 0.0111
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0011 0.0031
Echinococcus granulosus peptide allatostatin:somatostatin 0.0014 0.0035 0.0111
Schistosoma mansoni d-amino acid oxidase 0.2231 1 1
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0214 0.0934 0.0933
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0069 0.0282 0.0931
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0018 0.0016
Schistosoma mansoni cpg binding protein 0.0028 0.0098 0.0097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0014 0.0035 0.0111
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0239 0.0789
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0011 0.0009
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0007 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0014
Onchocerca volvulus 0.0014 0.0035 0.034
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0135 0.1654
Brugia malayi follicle stimulating hormone receptor 0.0014 0.0035 0.034
Brugia malayi cytochrome P450 0.0007 0.0002 0.0012
Echinococcus granulosus ribonuclease H1 0.0034 0.0125 0.0411
Echinococcus granulosus 7TM GPCR rhodopsin 0.0014 0.0035 0.0111
Onchocerca volvulus Ribonuclease H1 homolog 0.0034 0.0125 0.1259
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0186 0.0807 0.8194
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0011 0.0009
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0035 0.0111
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.0008 0.0009 0.0006
Schistosoma mansoni neuropeptide receptor 0.0014 0.0035 0.0033
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0011 0.0031
Trypanosoma cruzi DNA topoisomerase II, putative 0.0037 0.0135 0.1365
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.0008 0.0009 0.0008
Onchocerca volvulus 0.0014 0.0035 0.034
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0026 0.009 0.0295
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Brugia malayi RNase H family protein 0.0034 0.0125 0.1259
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi nuclear hormone receptor 0.0019 0.0055 0.0543
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0014 0.0035 0.0033
Loa Loa (eye worm) carboxylesterase 0.0034 0.0126 0.0124
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Echinococcus granulosus hypothetical protein 0.0209 0.0911 0.3017
Loa Loa (eye worm) TOPoisomerase family member 0.004 0.0151 0.015
Echinococcus granulosus neuropeptide receptor A26 0.0466 0.2066 0.6844
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0011 0.0095
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0035 0.0111
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0002 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Echinococcus multilocularis jun protein 0.0026 0.009 0.0295
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0033 0.012 0.0392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Echinococcus multilocularis neuropeptide receptor 0.0014 0.0035 0.0111
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0011 0.0009
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0251 0.025
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0037 0.0135 0.0501
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Brugia malayi hypothetical protein 0.0021 0.0065 0.0646
Mycobacterium ulcerans D-amino acid oxidase Aao 0.2231 1 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0002 0.0001
Chlamydia trachomatis DNA gyrase subunit A 0.0029 0.0099 0.0758
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0029 0.01 0.0816
Plasmodium vivax DNA gyrase subunit B, putative 0.0049 0.0193 0.1594
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0014 0.0035 0.0111
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0011 0.0031
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus hyperpolarization activated cyclic 0.0007 0.0003 0.0005
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0011 0.0095
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0008 0.0009 0.0063
Giardia lamblia Ribonuclease H 0.0034 0.0125 0.1537
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0035 0.0111
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0011 0.0009
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0642 0.2856 0.9463
Trypanosoma brucei ingi protein (ORF1) 0.0048 0.0186 0.0692
Loa Loa (eye worm) G-protein coupled receptor 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0186 0.0807 0.0805
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0035 0.0111
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.0001 0.008
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0275 0.1206 1
Brugia malayi amidase 0.0069 0.0282 0.2855
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.004 0.0151 0.0498
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0135 0.1356
Echinococcus multilocularis T cell transcription factor 4 long C terminal 0.0045 0.0174 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0251 0.025
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0033 0.0104
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0135 0.0442
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0007 0.0003 0.0005
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0186 0.0807 0.669
Echinococcus multilocularis serotonin receptor 0.0014 0.0035 0.0111
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0035 0.0111
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0014 0.0035 0.034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0055 0.0053
Schistosoma mansoni growth hormone secretagogue receptor 0.0014 0.0035 0.0033
Echinococcus multilocularis hormone sensitive lipase 0.0214 0.0934 0.3092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0014 0.0035 0.0033
Brugia malayi conserved hypotetical protein 0.0009 0.0011 0.0095
Leishmania major cytochrome p450-like protein 0.0007 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0086
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0035 0.0033
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Schistosoma mansoni jun-related protein 0.0022 0.0068 0.0067
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0002 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0146 0.0144
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0002 0.0001
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0014 0.0035 0.0033
Echinococcus multilocularis neuropeptide FF receptor 2 0.0014 0.0035 0.0111
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0007 0.0001 0.008
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0035 0.0131 0.043
Schistosoma mansoni cpg binding protein 0.003 0.0105 0.0104
Mycobacterium ulcerans peptide amidase, GatA 0.0008 0.0009 0.0006
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0011 0.0095
Schistosoma mansoni fatty-acid amide hydrolase 0.0008 0.0009 0.0008
Brugia malayi RE15519p 0.0014 0.0035 0.034
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0011 0.0031
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0033 0.012 0.1203
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus somatostatin receptor 0.0014 0.0035 0.0111
Giardia lamblia Reverse transcriptase/endonuclease 0.0014 0.0033 0.039
Brugia malayi nuclear receptor RXR 0.0009 0.0011 0.0095
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0015 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0055 0.0177
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0035 0.0111
Brugia malayi Amidase family protein 0.0008 0.0009 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0011 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0035 0.0111
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0035 0.0111
Brugia malayi nuclear hormone receptor 0.0009 0.0011 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0251 0.025
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0008 0.0009 0.0025
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0035 0.0111
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0014 0.0035 0.0111
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0186 0.0807 0.0805
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.0001 0.008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0014 0.0035 0.0111
Echinococcus granulosus tm gpcr rhodopsin 0.0014 0.0035 0.0111
Schistosoma mansoni amine GPCR 0.0014 0.0035 0.0033
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0002 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0251 0.2539
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0014 0.0035 0.0111
Echinococcus multilocularis serotonin receptor 0.0014 0.0035 0.0111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0055 0.0053
Trypanosoma brucei unspecified product 0.0048 0.0186 0.0692
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0035 0.0111
Brugia malayi RNase H family protein 0.0034 0.0125 0.1259
Schistosoma mansoni amine GPCR 0.0014 0.0035 0.0033
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0011 0.0031
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0212 0.1745
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0011 0.0095
Loa Loa (eye worm) TYRA-2 protein 0.0014 0.0035 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0011 0.0031
Brugia malayi bZIP transcription factor family protein 0.0026 0.009 0.0906
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.0008 0.0009 0.0008
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.0008 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0011 0.0095
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni amine GPCR 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0033 0.0319
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0033 0.012 0.1468
Echinococcus granulosus hypothetical protein 0.0014 0.0035 0.0111
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0014 0.0033 0.0104
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0186 0.0807 0.0806
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0055 0.0053
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0008 0.0009 0.0063
Echinococcus multilocularis neuropeptides capa receptor 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0098
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Trichomonas vaginalis ribonuclease H1, putative 0.0034 0.0125 0.8265
Schistosoma mansoni cpg binding protein 0.003 0.0105 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0055 0.0543
Loa Loa (eye worm) hypothetical protein 0.0029 0.0099 0.0098
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0007 0.0001 0.008
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0006
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0002 0.0012
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0135 0.1654
Brugia malayi GnHR receptor homolog 0.0014 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0135 0.1356
Schistosoma mansoni coup transcription factor 0.0019 0.0055 0.0053
Echinococcus multilocularis ribonuclease H1 0.0034 0.0125 0.0411
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Echinococcus granulosus sex peptide receptor 0.0014 0.0035 0.0111
Treponema pallidum exodeoxyribonuclease (exoA) 0.0033 0.012 0.0982
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0002 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0055 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0055 0.0053
Schistosoma mansoni biogenic amine receptor 0.0014 0.0035 0.0033
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0014 0.0035 0.0111
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0033 0.039
Loa Loa (eye worm) cytochrome P450 0.0007 0.0002 0.0001
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0239 0.0789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0002 0.0012
Brugia malayi nuclear receptor RXR 0.001 0.0015 0.0143
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0186 0.0807 1
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0186 0.0807 0.669
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0003 0.0002
Giardia lamblia DNA topoisomerase II 0.0039 0.0144 0.1777
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0033 0.012 0.1203
Echinococcus multilocularis neuropeptide receptor A26 0.0466 0.2066 0.6844
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0055 0.0177
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0055 0.0177
Entamoeba histolytica DNA topoisomerase II, putative 0.004 0.0151 0.1863
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0035 0.0131 0.043
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0239 0.0238
Onchocerca volvulus Neuropeptide F receptor homolog 0.0014 0.0035 0.034
Echinococcus granulosus hormone sensitive lipase 0.0214 0.0934 0.3092
Brugia malayi DNA topoisomerase II, alpha isozyme 0.004 0.0151 0.1526
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0014 0.0035 0.0033
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0014 0.0035 0.034
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0186 0.0807 0.8194
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0018 0.0054
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0035 0.0111
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0011 0.0031
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0002 0.0012
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0131 0.056 0.0558
Brugia malayi Melatonin receptor type 1A 0.0014 0.0035 0.034
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0049 0.0193 0.021
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0035 0.0111
Brugia malayi CXXC zinc finger family protein 0.0028 0.0098 0.0985
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0003 0.0188
Echinococcus granulosus neuropeptide FF receptor 2 0.0014 0.0035 0.0111
Brugia malayi G-protein coupled receptor 0.0014 0.0035 0.034
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0033
Onchocerca volvulus 0.0014 0.0035 0.034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Brugia malayi Dopamine receptor protein 2 0.0014 0.0035 0.034
Brugia malayi TAR-binding protein 0.0062 0.0251 0.2539
Echinococcus multilocularis G-protein coupled receptor, putative 0.0014 0.0035 0.0111
Trichomonas vaginalis reverse transcriptases, putative 0.0014 0.0033 0.2156
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus microtubule associated protein 2 0.0678 0.3018 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0014 0.0035 0.0111
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0014 0.0033 0.0117
Brugia malayi Cytochrome P450 family protein 0.0007 0.0002 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0251 0.025
Trypanosoma brucei DNA topoisomerase ii 0.0057 0.0228 0.0846
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Echinococcus granulosus fatty acid amide hydrolase 1 0.0008 0.0009 0.0025
Brugia malayi Carboxylesterase family protein 0.0034 0.0126 0.1264
Loa Loa (eye worm) RNA binding protein 0.0062 0.0251 0.025
Trypanosoma cruzi amidase, putative 0.0008 0.0009 0.0077
Loa Loa (eye worm) DR-78 0.0009 0.0011 0.0009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0055 0.0053
Brugia malayi ecdysone receptor 0.0009 0.0011 0.0095
Mycobacterium ulcerans amidase 0.0008 0.0009 0.0006
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.2045 0.9164 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0126 0.0124
Schistosoma mansoni phosphoglucomutase 0.0034 0.0125 0.0124
Echinococcus granulosus g protein coupled receptor 0.0014 0.0035 0.0111
Schistosoma mansoni hypothetical protein 0.0134 0.0574 0.0573
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0002 0.0004
Brugia malayi Cytochrome P450 family protein 0.0007 0.0002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0033 0.012 0.0129
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0014
Brugia malayi reverse transcriptase 0.0014 0.0033 0.0319
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0186 0.0807 0.0805
Onchocerca volvulus 0.0014 0.0035 0.034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0055 0.0543
Brugia malayi tailless protein 0.0009 0.0011 0.0095
Brugia malayi putative neuropeptide receptor 0.0014 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0055 0.0543
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0033 0.012 0.7898
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0186 0.0807 0.088
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.012 0.7952
Trypanosoma brucei RNA helicase, putative 0.0603 0.268 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus biogenic amine 5HT receptor 0.0014 0.0035 0.0111
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0186 0.0807 0.2672
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0055 0.0543
Schistosoma mansoni hypothetical protein 0.0022 0.0068 0.0067
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0103 0.0436 0.4421
Echinococcus granulosus fatty acid amide hydrolase 1 0.0069 0.0282 0.0931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0055 0.0053
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0186 0.0807 0.2672
Onchocerca volvulus Huntingtin homolog 0.012 0.0512 0.5195
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.0008 0.0009 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0011 0.0009
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0007 0.0003 0.0002
Echinococcus multilocularis microtubule associated protein 2 0.0678 0.3018 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0135 0.0442
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0014 0.0035 0.034
Brugia malayi HMG box family protein 0.0045 0.0174 0.1759
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0014 0.0035 0.034
Echinococcus granulosus fmrfamide receptor 0.0014 0.0035 0.0111
Toxoplasma gondii DNA topoisomerase 2, putative 0.004 0.0151 0.1246
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.012 0.0512 0.0511
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0186 0.0807 0.0805
Echinococcus granulosus alpha 1A adrenergic receptor 0.0014 0.0035 0.0111
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0011 0.0095
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0015 0.0143
Leishmania major DNA topoisomerase ii 0.0037 0.0135 0.1365
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0007 0.0001 0.008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0177 0.0765 0.0764
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0055 0.0053
Brugia malayi Probable DNA topoisomerase II 0.004 0.0151 0.1526
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0055 0.0053
Echinococcus granulosus serotonin receptor 0.0014 0.0035 0.0111
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0033 0.0104
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0049 0.0193 0.1541
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0055 0.0053
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0055 0.0543
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0055 0.0543
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0135 0.0442
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0214 0.0934 0.0933
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0033 0.012 0.1468
Schistosoma mansoni hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0055 0.0053
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0186 0.0807 0.0806
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Schistosoma mansoni opsin-like receptor 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.004 0.0151 0.1526
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0002 0.0001
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0275 0.1206 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0069 0.0282 0.0281
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0014 0.0035 0.0033
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0011 0.0031
Schistosoma mansoni voltage-gated potassium channel 0.0007 0.0003 0.0002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0035 0.0131 0.013
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0007 0.0003 0.0188
Echinococcus multilocularis hyperpolarization activated cyclic 0.0007 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0008 0.0007 0.0006
Echinococcus multilocularis RNA directed DNA polymerase 0.0014 0.0033 0.0104
Loa Loa (eye worm) hypothetical protein 0.0186 0.0807 0.0806
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Echinococcus granulosus KRAB A domain containing protein 0.0014 0.0033 0.0104
Echinococcus granulosus tar DNA binding protein 0.0062 0.0251 0.0828
Toxoplasma gondii exonuclease III APE 0.0033 0.012 0.0982
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Onchocerca volvulus 0.0019 0.0055 0.0543
Echinococcus granulosus T cell transcription factor 4 long C terminal 0.0045 0.0174 0.0573
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0251 0.025
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0055 0.0053
Echinococcus multilocularis sex peptide receptor 0.0014 0.0035 0.0111
Echinococcus granulosus fatty acid amide hydrolase 1 0.0069 0.0282 0.0931
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0055 0.0177
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0018 0.0054
Schistosoma mansoni phosphoglucomutase 0.0034 0.0125 0.0124
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0002 0.0001
Brugia malayi Serotonin receptor 0.0014 0.0035 0.034
Onchocerca volvulus 0.0014 0.0035 0.034
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0275 0.1206 0.1315
Brugia malayi hypothetical protein 0.012 0.0512 0.5195
Echinococcus multilocularis acetylcholinesterase 0.0034 0.0126 0.0412
Echinococcus granulosus neuropeptides capa receptor 0.0014 0.0035 0.0111
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0055 0.0177
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0035 0.0033
Schistosoma mansoni cytochrome P450 0.0007 0.0002 0.0001
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni adenoreceptor 0.0014 0.0035 0.0033
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0033 0.012 0.0118
Toxoplasma gondii hypothetical protein 0.0186 0.0807 0.669
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0008 0.0009 0.0008
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.0008 0.0009 0.0006
Loa Loa (eye worm) melatonin receptor type 1A 0.0014 0.0035 0.0033
Brugia malayi Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein 0.0225 0.0985 1
Echinococcus granulosus neuropeptide s receptor 0.0466 0.2066 0.6844
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0275 0.1206 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0239 0.026
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0135 0.0133
Schistosoma mansoni amidase 0.0069 0.0282 0.0281
Mycobacterium ulcerans amidase 0.0008 0.0009 0.0006
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0186 0.0807 0.2672
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0055 0.0053
Echinococcus granulosus acetylcholinesterase 0.0034 0.0126 0.0412
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0186 0.0807 0.0806
Brugia malayi Dopamine receptor protein 1 0.0014 0.0035 0.034
Echinococcus multilocularis neuropeptide Y receptor 0.0014 0.0035 0.0111
Schistosoma mansoni ap endonuclease 0.0033 0.012 0.0118
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0055 0.0177
Brugia malayi G-protein coupled receptor 0.0014 0.0035 0.034
Loa Loa (eye worm) amidase 0.0008 0.0009 0.0008
Loa Loa (eye worm) hypothetical protein 0.012 0.0512 0.0511
Schistosoma mansoni biogenic amine (5HT) receptor 0.0014 0.0035 0.0033
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0014 0.0035 0.0033
Onchocerca volvulus Huntingtin homolog 0.012 0.0512 0.5195
Trypanosoma cruzi phospholipase A2-like protein, putative 0.0103 0.0436 0.4421
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0186 0.0807 0.3009
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Echinococcus multilocularis acetylcholinesterase 0.0034 0.0126 0.0412
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0186 0.0807 0.8194
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.0008 0.0009 0.0028
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0186 0.0807 0.8194
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0033 0.012 0.7952
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0186 0.0807 1
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0008 0.0009 0.0025
Brugia malayi neuropeptide F receptor 0.0014 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0135 0.1356
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Schistosoma mansoni zinc finger protein 0.0009 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0014
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0049 0.0193 0.1594
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0002 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0002 0.0004
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.0008 0.0009 0.0008
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.024 0.0239
Schistosoma mansoni neuropeptide F-like receptor 0.0014 0.0035 0.0033
Leishmania major hypothetical protein, conserved 0.0008 0.0009 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0014 0.0033 0.0031
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0014 0.0035 0.0033
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0014 0.0035 0.0033
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0007 0.0003 0.0002
Schistosoma mansoni neuropeptide receptor 0.0014 0.0035 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0055 0.0177
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0002 0.0001
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0069 0.0282 0.0931
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0186 0.0807 0.2672
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0214 0.0934 0.0933
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0048 0.0186 0.0692
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0014 0.0035 0.0111
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0055 0.0543
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0015 0.0014
Schistosoma mansoni myosin xvIII 0.0014 0.0035 0.0033
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0014 0.0033 0.2156
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0002 0.0001
Loa Loa (eye worm) neuropeptide F receptor 0.0014 0.0035 0.0033
Echinococcus granulosus g protein coupled receptor 0.0014 0.0035 0.0111
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0014 0.0035 0.0111
Echinococcus granulosus G protein coupled receptor 139 0.0014 0.0035 0.0111
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0011 0.0009
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.0109
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0002 0.0001
Trichomonas vaginalis DNA topoisomerase II, putative 0.004 0.0151 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0016
Trypanosoma cruzi phospholipase A1, putative 0.0225 0.0985 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0146 0.0144
Schistosoma mansoni hypothetical protein 0.0603 0.268 0.2679
Schistosoma mansoni histamine h1 receptor 0.0014 0.0035 0.0033
Schistosoma mansoni fad oxidoreductase 0.0186 0.0807 0.0806
Echinococcus granulosus tachykinin peptides receptor 99D 0.0014 0.0035 0.0111
Loa Loa (eye worm) HMG box family protein 0.0045 0.0174 0.0173
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0239 0.0237
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0239 0.2421
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0014 0.0035 0.0033
Schistosoma mansoni pangolin 0.0045 0.0174 0.0173
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0002 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0055 0.0543
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0055 0.0543
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0014 0.0035 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0135 0.889
Trichomonas vaginalis reverse transcriptases, putative 0.0014 0.0033 0.2156
Echinococcus multilocularis somatostatin receptor 0.0014 0.0035 0.0111
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0011 0.0095
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0002 0.0001
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0008 0.0009 0.0063
Brugia malayi RNA binding protein 0.0062 0.0251 0.2539
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0002 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0055 0.0053
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0186 0.0807 0.0805
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0008 0.0009 0.0025
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0014 0.0035 0.0111
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0005
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0014 0.0033 0.0104
Onchocerca volvulus 0.0014 0.0035 0.034
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Chlamydia trachomatis DNA gyrase subunit B 0.0049 0.0193 0.1541
Brugia malayi Pao retrotransposon peptidase family protein 0.0014 0.0033 0.0319
Loa Loa (eye worm) hypothetical protein 0.001 0.0015 0.0014
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0186 0.0807 0.669
Echinococcus granulosus neuropeptide Y receptor 0.0014 0.0035 0.0111
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0239 0.0238
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0007 0.0003 0.0005
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0011 0.0095
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0057 0.0228 0.2303
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0014 0.0033 0.0104
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0007 0.0001 0.008
Loa Loa (eye worm) acetylcholinesterase 1 0.0034 0.0126 0.0124
Echinococcus granulosus RNA directed DNA polymerase 0.0014 0.0033 0.0104
Mycobacterium ulcerans amidase 0.0008 0.0009 0.0006
Brugia malayi RE18450p 0.0186 0.0807 0.8194
Leishmania major mitochondrial DNA topoisomerase II 0.0057 0.0228 0.2303
Brugia malayi hypothetical protein 0.0014 0.0035 0.034
Schistosoma mansoni fad oxidoreductase 0.0186 0.0807 0.0806
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0055 0.0053
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0135 0.889
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0002 0.0001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0135 0.0442
Schistosoma mansoni DNA topoisomerase II 0.004 0.0151 0.015
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0135 0.0442
Onchocerca volvulus 0.0014 0.0035 0.034
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0014 0.0035 0.034
Brugia malayi Serotonin receptor 0.0014 0.0035 0.034
Echinococcus granulosus cpg binding protein 0.003 0.0105 0.0345
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0135 0.1356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni hypothetical protein 0.0007 0.0002 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0031
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0018 0.0054
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0035 0.0111
Onchocerca volvulus 0.0009 0.0011 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0019 0.0055 0.0053
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0055 0.0177
Plasmodium vivax DNA gyrase subunit A, putative 0.0275 0.1206 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0033
Schistosoma mansoni amine GPCR 0.0014 0.0035 0.0033
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0014 0.0033 0.039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0009
Echinococcus multilocularis g protein coupled receptor 0.0014 0.0035 0.0111
Schistosoma mansoni protein kinase 0.0014 0.0033 0.0031
Brugia malayi Amidase family protein 0.0008 0.0009 0.0077
Brugia malayi ORL1-like opioid receptor 0.0014 0.0035 0.034
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0011 0.0009
Brugia malayi Cyclic-nucleotide gated cation channel 0.0007 0.0003 0.0017
Echinococcus multilocularis rhodopsin orphan GPCR 0.0014 0.0035 0.0111
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0055 0.0177
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0055 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0055 0.0177
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0034 0.0125 0.0972
Plasmodium vivax DNA topoisomerase II, putative 0.004 0.0151 0.1246
Brugia malayi hypothetical protein 0.0009 0.0011 0.0095
Trypanosoma cruzi ribonuclease H1, putative 0.0034 0.0125 0.1259
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0239 0.1977
Echinococcus multilocularis g-protein coupled receptor 0.0014 0.0035 0.0111
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0014 0.0035 0.0033

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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