Detailed information for compound 627591

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 270.298 | Formula: C12H12F2N2OS
  • H donors: 0 H acceptors: 1 LogP: 2.96 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N=c1sc2c(n1CC)c(F)cc(c2)F
  • InChi: 1S/C12H12F2N2OS/c1-3-10(17)15-12-16(4-2)11-8(14)5-7(13)6-9(11)18-12/h5-6H,3-4H2,1-2H3/b15-12-
  • InChiKey: YNGUECBMCOKOQH-QINSGFPZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0175 0.4952
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0078 0.0063
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0284 0.1466
Brugia malayi Heterochromatin protein 1 0.0069 0.0466 0.0466
Schistosoma mansoni lipoxygenase 0.0088 0.0616 0.3281
Brugia malayi hypothetical protein 0.0074 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.1251 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0068 0.0201
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0726 0.0726
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0754 0.2859
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0512
Loa Loa (eye worm) hypothetical protein 0.0069 0.0468 0.0468
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0142 0.1359
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0515 0.273
Echinococcus multilocularis pyruvate kinase 0.0033 0.0175 0.0161
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0068 0.0085
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0167 0.0167
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0109 0.2681
Onchocerca volvulus 0.003 0.0153 0.0399
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0047 0.0053
Trichomonas vaginalis esterase, putative 0.0036 0.0196 0.0605
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0068 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0098 0.0931
Echinococcus granulosus Aminotransferase class III 0.0046 0.028 0.0265
Trypanosoma brucei unspecified product 0.002 0.0068 0.0673
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0047 0.002
Brugia malayi hypothetical protein 0.0233 0.1791 0.1791
Schistosoma mansoni hypothetical protein 0.0029 0.0142 0.0691
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0754 0.4029
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0196
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0175 0.0319
Brugia malayi beta-lactamase family protein 0.0036 0.0196 0.0196
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0089 0.0074
Mycobacterium tuberculosis Conserved protein 0.0036 0.0196 0.0622
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0238 0.1219
Onchocerca volvulus 0.0036 0.0196 0.0626
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0831
Entamoeba histolytica hypothetical protein 0.0074 0.0505 1
Plasmodium falciparum thioredoxin reductase 0.0017 0.0047 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0068 0.0068
Leishmania major hypothetical protein, conserved 0.0036 0.0196 0.2292
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0059 0.019
Onchocerca volvulus 0.0235 0.1803 0.9098
Schistosoma mansoni ap endonuclease 0.0019 0.0059 0.024
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0142 0.0127
Loa Loa (eye worm) beta-lactamase 0.0036 0.0196 0.0196
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0308 0.0308
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0196
Echinococcus multilocularis pyruvate kinase 0.0017 0.0045 0.0031
Trypanosoma brucei protein kinase, putative 0.0105 0.0754 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0095 0.0095
Mycobacterium tuberculosis Probable reductase 0.0113 0.0819 0.3137
Echinococcus multilocularis mitogen activated protein kinase 3 0.0105 0.0754 0.074
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0109 0.0901
Mycobacterium tuberculosis Probable dehydrogenase 0.0113 0.0819 0.3137
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0059 0.0044
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1803 0.7106
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0109 1
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0175 0.0537
Schistosoma mansoni pyruvate kinase 0.0033 0.0175 0.0875
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.043 0.0415
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0206 0.1042
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.001 0.001
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0167 0.0167
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0047 0.0221
Brugia malayi chromobox protein homolog 3 0.0039 0.0221 0.0221
Echinococcus multilocularis ornithine aminotransferase 0.0046 0.028 0.0265
Schistosoma mansoni hypothetical protein 0.0168 0.1264 0.6814
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0196 0.0196
Plasmodium falciparum ornithine aminotransferase 0.0046 0.028 0.8926
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0098 0.0208
Giardia lamblia Kinase, CMGC MAPK 0.0105 0.0754 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0098 0.0208
Onchocerca volvulus 0.0036 0.0196 0.0626
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0046 0.028 0.028
Onchocerca volvulus 0.0024 0.0098 0.0107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.1848 0.1836
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0098 0.0098
Toxoplasma gondii ABC1 family protein 0.0036 0.0196 0.2133
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.043 0.552
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0109 0.2432
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.039 0.039
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0068 0.0085
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0308 0.1071
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0622 0.0622
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0196
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0175 0.0175
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0078 0.0063
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0196 0.0622
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.6395 0.6389
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0045 0.003
Onchocerca volvulus Huntingtin homolog 0.0256 0.1974 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0047 0.0053
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0466 0.1695
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0059 0.0514
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0468 0.0468
Schistosoma mansoni hypothetical protein 0.0048 0.0293 0.1514
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.0673
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.043 0.2263
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.043 0.0415
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0068 0.0085
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0047 0.002
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0046 0.028 0.0958
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0221 0.0704
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.004 0.0234 0.0234
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0831
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0196 0.0182
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0109 0.2432
Schistosoma mansoni hypothetical protein 0.0021 0.0078 0.0342
Echinococcus granulosus dna polymerase eta 0.002 0.0068 0.0053
Schistosoma mansoni polycystin 1-related 0.0021 0.0078 0.0342
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.0673
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0196 0.0182
Plasmodium falciparum thioredoxin reductase 0.0049 0.0308 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.1848 0.1836
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0142 0.0127
Brugia malayi Bromodomain containing protein 0.0031 0.0161 0.0161
Schistosoma mansoni DNA polymerase eta 0.002 0.0068 0.0289
Schistosoma mansoni hypothetical protein 0.0074 0.0505 0.2674
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Echinococcus granulosus chromobox protein 1 0.0069 0.0466 0.0451
Plasmodium vivax SET domain protein, putative 0.003 0.0147 0.3882
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0068 0.0512
Loa Loa (eye worm) hypothetical protein 0.0047 0.0284 0.0284
Echinococcus multilocularis RUN 0.0021 0.0078 0.0063
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0098
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0068 0.0053
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0754 0.2859
Plasmodium falciparum glutathione reductase 0.0049 0.0308 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0125 0.0921 0.3399
Echinococcus granulosus muscleblind protein 0.1251 1 1
Echinococcus granulosus RUN 0.0021 0.0078 0.0063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0113 0.0819 0.2979
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0196 0.2292
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.1251 1 1
Echinococcus granulosus ornithine aminotransferase 0.0046 0.028 0.0265
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0293 0.0293
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0059 0.0514
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0196 0.0605
Schistosoma mansoni chromobox protein 0.0069 0.0466 0.2459
Mycobacterium tuberculosis Probable oxidoreductase 0.0125 0.0921 0.3547
Leishmania major pyruvate kinase 0.0033 0.0175 0.1999
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.005 0.0144
Echinococcus granulosus pyruvate kinase 0.0033 0.0175 0.0161
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0175 0.2134
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0046 0.028 0.0942
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0047 0.0387
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0059 0.0388
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0206 0.0206
Brugia malayi Pre-SET motif family protein 0.003 0.0147 0.0147
Loa Loa (eye worm) glutathione reductase 0.0049 0.0308 0.0308
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0046 0.028 1
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0046 0.028 0.0942
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.043 0.1564
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0284 0.0269
Schistosoma mansoni bromodomain containing protein 0.0063 0.0415 0.2181
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.001 0.001
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0233 0.0218
Mycobacterium tuberculosis Probable aminotransferase 0.0324 0.2519 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0175 0.052
Onchocerca volvulus 0.0036 0.0196 0.0626
Giardia lamblia PHD finger protein 15 0.0029 0.0142 0.1359
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Echinococcus multilocularis dna polymerase kappa 0.002 0.0068 0.0053
Mycobacterium ulcerans L-lysine aminotransferase 0.0046 0.028 0.0942
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0505 0.0491
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0138 0.0124
Brugia malayi MAP kinase sur-1 0.0105 0.0754 0.0754
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0672 0.0658
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0153
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0059 0.0551
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0175 0.1999
Brugia malayi Pre-SET motif family protein 0.0206 0.1573 0.1573
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0147 0.1438
Echinococcus granulosus zinc finger protein 0.0019 0.0065 0.005
Brugia malayi hypothetical protein 0.0021 0.0078 0.0078
Brugia malayi jmjC domain containing protein 0.0095 0.0672 0.0672
Echinococcus multilocularis zinc finger protein 0.0019 0.0065 0.005
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0078 0.0078
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.024 0.1848 0.1836
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0105 0.0754 1
Brugia malayi Bromodomain containing protein 0.0038 0.0215 0.0215
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0512
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0047 0.0221
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0754 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0196 0.0622
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0512
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0089 0.0403
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0068 0.0512
Plasmodium falciparum glutathione reductase 0.0017 0.0047 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0125 0.0921 0.3547
Toxoplasma gondii thioredoxin reductase 0.0049 0.0308 0.3704
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0831
Plasmodium vivax ornithine aminotransferase, putative 0.0046 0.028 0.8926
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0047 0.0053
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0175 0.0514
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0175 0.0514
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.0921 0.0907
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0059 0.1937
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0059 0.0067
Echinococcus granulosus chromobox protein 1 0.0069 0.0466 0.0451
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0308 0.3831
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0175 0.0175
Leishmania major pyruvate kinase 0.0033 0.0175 0.1999
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0047 0.0221
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0175 0.0514
Echinococcus granulosus peregrin 0.0031 0.0161 0.0146
Entamoeba histolytica hypothetical protein 0.0074 0.0505 1
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0196 0.0622
Loa Loa (eye worm) hypothetical protein 0.003 0.0153 0.0153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0196 0.099
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.005 0.0031
Schistosoma mansoni survival motor neuron protein 0.0048 0.0293 0.1514
Echinococcus granulosus dna polymerase kappa 0.002 0.0068 0.0053
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0068 0.0289
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0308 0.0293
Brugia malayi PHD-finger family protein 0.0025 0.0108 0.0108
Echinococcus multilocularis GPCR, family 2 0.0032 0.0167 0.0153
Plasmodium vivax glutathione reductase, putative 0.0049 0.0308 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.043 0.1549
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0068 0.0512
Brugia malayi SET domain containing protein 0.0012 0.0008 0.0008
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0196 0.0605
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0175 0.1834
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0175 0.0175
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0045 0.0163
Echinococcus multilocularis pyruvate kinase 0.0017 0.0045 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.013 0.0335
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0074 0.0505 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0386 0.0372
Entamoeba histolytica hypothetical protein 0.0074 0.0505 1
Brugia malayi Bromodomain containing protein 0.0074 0.0508 0.0508
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0622 0.0608
Mycobacterium tuberculosis Conserved protein 0.0036 0.0196 0.0622
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0046 0.028 0.0958
Echinococcus granulosus pyruvate kinase 0.0017 0.0045 0.0031
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0142 0.1359
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0167 0.0167
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0046 0.028 0.0958
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.002 0.0074 0.0319
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0015 0.0031 0.0087
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0754 0.2859
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0059 0.0049
Echinococcus granulosus pyruvate kinase 0.0033 0.0175 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0324 0.2519 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0068 0.0317
Brugia malayi glutathione reductase 0.0049 0.0308 0.0308
Plasmodium falciparum phd finger protein, putative 0.0029 0.0142 0.3669
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0089 0.0074
Loa Loa (eye worm) hypothetical protein 0.0256 0.1974 0.1974
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0221 0.0755
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0068 0.0103
Loa Loa (eye worm) hypothetical protein 0.005 0.0308 0.0308
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.005 0.0014
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0466 0.1695
Echinococcus multilocularis ornithine aminotransferase 0.0046 0.028 0.0265
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0109 0.2681
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0009 0.0009
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.005 0.0181
Echinococcus granulosus geminin 0.0168 0.1264 0.1251
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0059 0.0059
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0059 0.0049
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0109 0.0252
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0174
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0098 0.0208
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0622 0.0608
Onchocerca volvulus Huntingtin homolog 0.0256 0.1974 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.1848 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0175 0.052
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0098 0.0931
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1791 0.1779
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0284 0.1466
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Echinococcus multilocularis muscleblind protein 0.1251 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0672 0.0658
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0046 0.028 0.1443
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0175 0.0175
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0047 0.0221
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.024 0.1848 0.1848
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0045 0.0163
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0113 0.0819 0.3137
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0105 0.0754 0.0754
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0109 0.0252
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0095 0.0799
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0098 0.0208
Schistosoma mansoni loxhd1 0.0021 0.0078 0.0342
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.024 0.1848 0.1836
Echinococcus multilocularis Aminotransferase class III 0.0046 0.028 0.0265
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0069 0.0468 0.2469
Mycobacterium ulcerans hypothetical protein 0.0324 0.2519 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0047 0.0387
Brugia malayi CHD4 protein 0.0013 0.0015 0.0015
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0324 0.2519 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0068 0.0053
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0206 0.1042
Chlamydia trachomatis pyruvate kinase 0.0033 0.0175 0.5521
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0196 0.0181
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.043 0.5428
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0206 0.0191
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0046 0.028 0.0942
Mycobacterium tuberculosis Conserved protein 0.0036 0.0196 0.0622
Trypanosoma brucei ISWI complex protein 0.0015 0.0031 0.0169
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0098 0.0879
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1791 0.1779
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0125 0.0921 0.3547
Mycobacterium leprae Probable lipase LipE 0.0036 0.0196 0.0406
Brugia malayi Doublecortin family protein 0.0021 0.0078 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0078 0.0063
Echinococcus granulosus pyruvate kinase 0.0017 0.0045 0.0031
Onchocerca volvulus 0.0088 0.0622 0.2871
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0245 0.08
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0105 0.0754 1
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0109 0.0046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0196 0.0605
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.005 0.0181
Schistosoma mansoni pyruvate kinase 0.0017 0.0045 0.0166
Brugia malayi PHD-finger family protein 0.0029 0.0142 0.0142
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0045 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0196 0.0605
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0153
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0622 0.3313
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0196 0.0605
Mycobacterium ulcerans hypothetical protein 0.0036 0.0196 0.0605
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0078 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.013 0.0335
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0047 0.0053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.043 0.1549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.1848 1
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0175 0.052
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0046 0.028 0.3306
Schistosoma mansoni rab6-interacting 0.0021 0.0078 0.0342
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.0921 0.0907
Trichomonas vaginalis CMGC family protein kinase 0.0105 0.0754 0.2859
Echinococcus multilocularis mitogen activated protein kinase 0.0105 0.0754 0.074
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0324 0.2519 1
Echinococcus granulosus mitogen activated protein kinase 0.0105 0.0754 0.074
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0153
Schistosoma mansoni zinc finger protein 0.0019 0.0065 0.0273
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0505 0.2674
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0324 0.2519 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0196
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0098 0.0208
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0196 0.0605
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0078 0.1232
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0098 0.0879
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0109 0.0901
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0068
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0142 0.0691
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0505 0.0491
Echinococcus multilocularis chromobox protein 1 0.0069 0.0466 0.0451
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0387
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0196 0.0196
Echinococcus granulosus mitogen activated protein kinase 3 0.0105 0.0754 0.074
Entamoeba histolytica hypothetical protein 0.0025 0.0109 0.1128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0196 0.099
Trypanosoma brucei trypanothione reductase 0.0049 0.0308 0.3936
Echinococcus multilocularis pyruvate kinase 0.0033 0.0175 0.0161
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0175
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0109 0.027
Loa Loa (eye worm) hypothetical protein 0.0233 0.1791 0.1791
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0105 0.0754 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.024 0.1848 0.1848
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0059 0.0059
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0032
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0196 0.0622
Brugia malayi hypothetical protein 0.0256 0.1974 0.1974
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Mycobacterium ulcerans lipase LipD 0.0036 0.0196 0.0605
Loa Loa (eye worm) hypothetical protein 0.0038 0.0215 0.0215
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0046 0.028 0.0958
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0147 0.0722
Schistosoma mansoni chromobox protein 0.0069 0.0466 0.2459
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0047 0.0018
Loa Loa (eye worm) hypothetical protein 0.0042 0.025 0.025
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0196 0.0622
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0245 0.08
Schistosoma mansoni hypothetical protein 0.0168 0.1264 0.6814
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0098
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0098 0.0225
Giardia lamblia Pyruvate kinase 0.0033 0.0175 0.1834
Toxoplasma gondii exonuclease III APE 0.0019 0.0059 0.019
Schistosoma mansoni rab6-interacting 0.0021 0.0078 0.0342
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0105 0.0754 1
Leishmania major DNA polymerase kappa, putative 0.002 0.0068 0.0512
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0059 0.0044
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Echinococcus multilocularis geminin 0.0168 0.1264 0.1251
Echinococcus multilocularis pyruvate kinase 0.0017 0.0045 0.0031
Mycobacterium ulcerans hypothetical protein 0.0024 0.0098 0.0208
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0046 0.028 0.075
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0196 0.2422
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0387
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0059 0.0388
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0098 0.0225
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0059 0.0049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0098 0.0931
Loa Loa (eye worm) hypothetical protein 0.0029 0.0142 0.0142
Brugia malayi Thioredoxin reductase 0.0049 0.0308 0.0308
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Echinococcus multilocularis chromobox protein 1 0.0069 0.0466 0.0451
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0175 0.2134
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0196 0.0605
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0047 0.002
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0047 0.0221
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0831
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0196 0.0406
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0113 0.0819 0.3137
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0196 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Echinococcus granulosus GPCR family 2 0.0032 0.0167 0.0153
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0046 0.028 1
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0109 0.1235
Brugia malayi beta-lactamase family protein 0.0036 0.0196 0.0196
Echinococcus multilocularis muscleblind protein 1 0.1251 1 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.005 0.005
Schistosoma mansoni pyruvate kinase 0.0033 0.0175 0.0875
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0245 0.088
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0068 0.0085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0059 0.0388
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0175 0.1999
Schistosoma mansoni ap endonuclease 0.0019 0.0059 0.024
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0068 0.0673
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0167
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.024 0.1848 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0098 0.0208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.043 0.1549
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0308 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0098 0.0879
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.043 0.2263
Brugia malayi hypothetical protein 0.0021 0.0078 0.0078
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0105 0.0754 1
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0078 0.1232
Echinococcus multilocularis dna polymerase eta 0.002 0.0068 0.0053
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0284 0.0269
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0196 0.0622
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0196 0.0622
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0095
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0046 0.028 0.075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0386 0.0372
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0142 0.0142
Mycobacterium ulcerans acetylornithine aminotransferase 0.0046 0.028 0.0942
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0078 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0047 0.0221
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0098 0.0208
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0046 0.028 0.075
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0068 0.0673
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0196 0.5759
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0221 0.0704
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0726 0.0726
Brugia malayi beta-lactamase 0.0036 0.0196 0.0196
Onchocerca volvulus 0.0041 0.0238 0.0847
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0078 0.0063
Echinococcus granulosus jumonji domain containing protein 0.004 0.0233 0.0218
Schistosoma mansoni zinc finger protein 0.0015 0.0031 0.0087
Onchocerca volvulus Alhambra homolog 0.0029 0.0142 0.0337
Loa Loa (eye worm) hypothetical protein 0.0021 0.0078 0.0078
Onchocerca volvulus 0.0048 0.0293 0.1132
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0068 0.0289
Leishmania major DNA polymerase eta, putative 0.002 0.0068 0.0512
Loa Loa (eye worm) hypothetical protein 0.0036 0.0196 0.0196
Echinococcus granulosus pyruvate kinase 0.0017 0.0045 0.0031
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0046 0.028 0.0942
Loa Loa (eye worm) hypothetical protein 0.0088 0.0622 0.0622
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1748 0.689
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0196 0.2292
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0105 0.0754 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0113 0.0819 0.3137
Brugia malayi jmjC domain containing protein 0.0037 0.0206 0.0206
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0059 0.0519
Loa Loa (eye worm) hypothetical protein 0.007 0.0474 0.0474
Loa Loa (eye worm) hypothetical protein 0.0039 0.0221 0.0221
Schistosoma mansoni lipoxygenase 0.0126 0.0921 0.4943
Loa Loa (eye worm) hypothetical protein 0.0101 0.0726 0.0726
Mycobacterium ulcerans beta-lactamase 0.0036 0.0196 0.0605
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0109 0.1085
Loa Loa (eye worm) hypothetical protein 0.0256 0.1974 0.1974
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0142 0.3669
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1573 0.1573
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0191 0.0176
Plasmodium falciparum pyruvate kinase 0.0033 0.0175 0.4952
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0015 0.0015
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0308 0.0293
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0047 0.0032
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0147 0.0132
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0105 0.0754 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0113 0.0819 0.3137
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0098 0.0098
Leishmania major trypanothione reductase 0.0049 0.0308 0.3831
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0068 0.0673
Echinococcus multilocularis pyruvate kinase 0.0026 0.0119 0.0104
Echinococcus multilocularis peregrin 0.0031 0.0161 0.0146

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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