Detailed information for compound 64888

Basic information

Technical information
  • TDR Targets ID: 64888
  • Name: 7-(1,2-oxazolidin-4-yl)-5-(4-phenoxyphenyl)py rrolo[2,3-d]pyrimidin-4-amine
  • MW: 373.408 | Formula: C21H19N5O2
  • H donors: 2 H acceptors: 2 LogP: 2.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1ncnc2c1c(cn2C1CONC1)c1ccc(cc1)Oc1ccccc1
  • InChi: 1S/C21H19N5O2/c22-20-19-18(11-26(15-10-25-27-12-15)21(19)24-13-23-20)14-6-8-17(9-7-14)28-16-4-2-1-3-5-16/h1-9,11,13,15,25H,10,12H2,(H2,22,23,24)
  • InChiKey: FZLOALBUJDUYTI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-isoxazolidin-4-yl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-amine
  • 7-(4-isoxazolidinyl)-5-(4-phenoxyphenyl)-4-pyrrolo[2,3-d]pyrimidinamine
  • [7-isoxazolidin-4-yl-5-(4-phenoxyphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine
  • 7-(1,2-oxazolidin-4-yl)-5-[4-(phenoxy)phenyl]pyrrolo[3,2-e]pyrimidin-4-amine
  • 7-isoxazolidin-4-yl-5-[4-(phenoxy)phenyl]pyrrolo[3,2-e]pyrimidin-4-amine
  • 7-(4-isoxazolidinyl)-5-[4-(phenoxy)phenyl]-4-pyrrolo[3,2-e]pyrimidinamine
  • [7-isoxazolidin-4-yl-5-[4-(phenoxy)phenyl]pyrrolo[3,2-e]pyrimidin-4-yl]amine

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens TEK tyrosine kinase, endothelial Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0032 0.0163 0.041
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0063 0.0427 0.0315
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0047 0.0081
Echinococcus multilocularis Tubulin beta 2C chain 0.0352 0.2862 0.5148
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0047 0.0159
Treponema pallidum ATP-binding protein (ylxH-1) 0.0522 0.4293 1
Onchocerca volvulus 0.0175 0.1369 0.8629
Brugia malayi CHE-14 protein 0.0056 0.0362 0.0958
Onchocerca volvulus Dual oxidase homolog 0.0091 0.0662 0.4167
Trypanosoma brucei carbonic anhydrase-like protein 0.012 0.0903 0.3041
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Echinococcus granulosus tubulin alpha chain 0.028 0.2255 0.3989
Trypanosoma brucei alpha tubulin 0.028 0.2255 0.7842
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2255 0.2164
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0135 0.1032 0.1824
Echinococcus granulosus tubulin subunit beta 0.0352 0.2862 0.5065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0373 0.0657
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0373 0.0668
Onchocerca volvulus Putative sulfate transporter 0.0201 0.1586 1
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0135 0.1032 0.2529
Giardia lamblia Beta tubulin 0.0352 0.2862 1
Brugia malayi tubulin alpha-2 chain 0.028 0.2255 0.5993
Entamoeba histolytica tubulin gamma chain 0.0197 0.155 0.3795
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0123 0.0219
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0135 0.1032 0.0884
Loa Loa (eye worm) SRC-1 0.0057 0.0373 0.1298
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0057 0.0373 0.0657
Giardia lamblia Beta tubulin 0.0352 0.2862 1
Leishmania major delta tubulin, putative 0.0085 0.0613 0.1401
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Echinococcus multilocularis Ankyrin 0.0015 0.0022 0.0036
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0195 0.1535 0.1436
Leishmania major calmodulin, putative 0.0026 0.0116 0.0171
Echinococcus granulosus sterol regulatory element binding protein 0.0056 0.0362 0.0638
Onchocerca volvulus Calmodulin homolog 0.0026 0.0116 0.0721
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0044 0.0266 0.0476
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0063 0.0427 0.0315
Trichomonas vaginalis tubulin gamma chain, putative 0.0085 0.0613 0.0502
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Echinococcus granulosus carbonic anhydrase 0.0027 0.0123 0.0215
Giardia lamblia Alpha-tubulin 0.028 0.2255 0.7788
Chlamydia trachomatis sulfate transporter 0.0032 0.0163 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0613 0.0502
Trichomonas vaginalis tubulin alpha chain, putative 0.0197 0.155 0.1451
Loa Loa (eye worm) tubulin alpha-2 chain 0.028 0.2255 0.7876
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.0158
Echinococcus granulosus tyrosine protein kinase HCK 0.0039 0.0222 0.039
Toxoplasma gondii alpha-tubulin I, putative 0.028 0.2255 0.7842
Echinococcus granulosus Tubulin alpha 1 chain 0.028 0.2255 0.3989
Echinococcus multilocularis Tubulin alpha 1 chain 0.028 0.2255 0.4055
Plasmodium falciparum carbonic anhydrase 0.0027 0.0123 0.027
Toxoplasma gondii alpha tubulin TUBA1 0.028 0.2255 0.7842
Trypanosoma cruzi calmodulin, putative 0.0026 0.0116 0.0244
Echinococcus granulosus tubulin alpha 3 chain 0.028 0.2255 0.3989
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0169 0.1317 0.1215
Loa Loa (eye worm) tubulin gamma chain 0.0197 0.155 0.5412
Echinococcus multilocularis peroxidasin 0.0091 0.0662 0.1188
Echinococcus multilocularis geminin 0.0196 0.1548 0.2782
Loa Loa (eye worm) hypothetical protein 0.004 0.0226 0.0783
Echinococcus granulosus carbonic anhydrase 0.0027 0.0123 0.0215
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0057 0.0373 0.0668
Echinococcus granulosus tyrosine protein kinase shark 0.0013 0.0003 0.0002
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.012 0.0903 0.2214
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0115
Trypanosoma brucei zeta tubulin, putative 0.0085 0.0613 0.2008
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0549 0.0968
Schistosoma mansoni peroxidasin 0.0091 0.0662 0.1622
Trypanosoma brucei calmodulin 0.0026 0.0116 0.0244
Leishmania major epsilon tubulin, putative 0.0197 0.155 0.3725
Echinococcus multilocularis protein patched 0.0056 0.0362 0.0648
Brugia malayi hypothetical protein 0.0175 0.1369 0.3636
Trichomonas vaginalis tubulin, putative 0.0111 0.0831 0.0723
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0135 0.1032 0.3498
Schistosoma mansoni tubulin subunit delta 0.0085 0.0613 0.1501
Echinococcus multilocularis beta tubulin 0.0352 0.2862 0.5148
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Trypanosoma cruzi beta tubulin, putative 0.0352 0.2862 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0047 0.0082
Entamoeba histolytica calmodulin, putative 0.0026 0.0116 0.028
Loa Loa (eye worm) alpha-tubulin 0.028 0.2255 0.7876
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Trichomonas vaginalis conserved hypothetical protein 0.12 1 1
Leishmania major calmodulin, putative 0.0026 0.0116 0.0171
Echinococcus granulosus tubulin subunit TubB 0.028 0.2255 0.3989
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Schistosoma mansoni tubulin subunit alpha 0.028 0.2255 0.5525
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Echinococcus multilocularis sterol regulatory element binding protein 0.0056 0.0362 0.0648
Onchocerca volvulus 0.0091 0.0662 0.4167
Trichomonas vaginalis tubulin alpha chain, putative 0.0111 0.0831 0.0723
Echinococcus multilocularis tubulin subunit TubB 0.028 0.2255 0.4055
Mycobacterium tuberculosis Cell division protein FtsZ 0.0085 0.0613 0.0715
Echinococcus granulosus tubulin alpha chain 0.028 0.2255 0.3989
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0123 0.0425
Schistosoma mansoni tubulin subunit beta 0.0352 0.2862 0.7014
Loa Loa (eye worm) BEN-1 protein 0.0352 0.2862 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0549 0.0984
Schistosoma mansoni tubulin subunit beta 0.0352 0.2862 0.7014
Entamoeba histolytica tubulin family protein 0.0352 0.2862 0.7013
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0373 0.0657
Echinococcus multilocularis Tubulin beta 2C chain 0.0352 0.2862 0.5148
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0044 0.0109
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0135 0.1032 0.3498
Echinococcus multilocularis peroxisome assembly protein 26 0.028 0.2255 0.4055
Brugia malayi Sex muscle abnormal protein 5 0.0018 0.0044 0.0113
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Brugia malayi Protein kinase domain containing protein 0.0015 0.0021 0.0051
Trypanosoma brucei epsilon tubulin 0.0197 0.155 0.5338
Echinococcus granulosus c src tyrosine kinase 0.0022 0.0077 0.0132
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0123 0.0323
Echinococcus granulosus alpha tubulin 0.028 0.2255 0.3989
Onchocerca volvulus 0.0111 0.0831 0.5231
Onchocerca volvulus Peroxidasin homolog 0.0091 0.0662 0.4167
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0063 0.0427 0.1133
Echinococcus multilocularis beta tubulin 0.0352 0.2862 0.5148
Echinococcus granulosus calmodulin 0.0026 0.0116 0.0202
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0163 0.041
Schistosoma mansoni hypothetical protein 0.0015 0.0021 0.0052
Echinococcus multilocularis tyrosine protein kinase shark 0.0013 0.0003 0.0002
Schistosoma mansoni alpha tubulin 0.028 0.2255 0.5525
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Schistosoma mansoni tubulin subunit gamma 0.0197 0.155 0.3798
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0135 0.1032 0.274
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0135 0.1032 0.1854
Schistosoma mansoni tubulin subunit beta 0.0085 0.0613 0.1501
Trypanosoma cruzi calmodulin, putative 0.0026 0.0116 0.0244
Echinococcus granulosus beta tubulin 0.0352 0.2862 0.5065
Echinococcus multilocularis calmodulin 0.0026 0.0116 0.0206
Trypanosoma cruzi epsilon tubulin, putative 0.0197 0.155 0.5338
Echinococcus multilocularis calmodulin 0.0026 0.0116 0.0205
Toxoplasma gondii beta-1 tubulin, putative 0.0352 0.2862 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0047 0.012
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.028 0.2255 0.2164
Trichomonas vaginalis tubulin beta chain, putative 0.0111 0.0831 0.0723
Onchocerca volvulus Peroxidase homolog 0.0091 0.0662 0.4167
Echinococcus multilocularis tubulin alpha 3 chain 0.028 0.2255 0.4055
Plasmodium vivax tubulin alpha chain, putative 0.028 0.2255 0.7842
Schistosoma mansoni calmodulin 0.0026 0.0116 0.0285
Schistosoma mansoni hypothetical protein 0.0027 0.0123 0.0302
Echinococcus multilocularis tubulin beta 1 chain 0.0352 0.2862 0.5148
Loa Loa (eye worm) hypothetical protein 0.0175 0.1369 0.4778
Echinococcus granulosus growth factor receptor bound protein 2 0.0018 0.0044 0.0075
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0123 0.0323
Trypanosoma brucei epsilon tubulin 0.0197 0.155 0.5338
Loa Loa (eye worm) BEN-1 protein 0.0352 0.2862 1
Schistosoma mansoni tubulin subunit beta 0.0352 0.2862 0.7014
Brugia malayi Animal haem peroxidase family protein 0.0091 0.0662 0.1756
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Toxoplasma gondii beta tubulin 0.0352 0.2862 1
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0123 0.0219
Schistosoma mansoni netrin receptor unc5 0.0015 0.0021 0.0052
Schistosoma mansoni tyrosine kinase 0.0013 0.0003 0.0007
Schistosoma mansoni patched 1 0.0056 0.0362 0.0887
Echinococcus granulosus carbonic anhydrase 0.0027 0.0123 0.0215
Echinococcus granulosus Ankyrin 0.0015 0.0022 0.0036
Mycobacterium ulcerans cell division protein FtsZ 0.0085 0.0613 0.0457
Echinococcus multilocularis GPCR, family 2 0.0018 0.0047 0.0081
Echinococcus multilocularis growth factor receptor bound protein 2 0.0018 0.0044 0.0076
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Brugia malayi Immunoglobulin I-set domain containing protein 0.0015 0.0021 0.0051
Loa Loa (eye worm) hypothetical protein 0.0169 0.1317 0.4598
Toxoplasma gondii hypothetical protein 0.0027 0.0123 0.027
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0255 0.2038 0.2517
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0197 0.155 0.5338
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Brugia malayi Tubulin alpha chain 0.028 0.2255 0.5993
Schistosoma mansoni tubulin subunit alpha 0.028 0.2255 0.5525
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Entamoeba histolytica tubulin alpha chain, putative 0.028 0.2255 0.5523
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0163 0.041
Plasmodium falciparum alpha tubulin 1 0.028 0.2255 0.7842
Entamoeba histolytica protein kinase, putative 0.0039 0.0222 0.0539
Leishmania major calmodulin, putative 0.0026 0.0116 0.0171
Echinococcus multilocularis c src tyrosine kinase 0.0022 0.0077 0.0134
Echinococcus multilocularis Tubulin alpha 1 chain 0.028 0.2255 0.4055
Leishmania major carbonic anhydrase-like protein 0.012 0.0903 0.2122
Trichomonas vaginalis tubulin, putative 0.0085 0.0613 0.0502
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.012 0.0903 0.3152
Brugia malayi Tubulin alpha-2 chain 0.028 0.2255 0.5993
Echinococcus granulosus peroxidasin 0.0091 0.0662 0.1169
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Echinococcus multilocularis netrin receptor unc 5 0.0015 0.0021 0.0034
Schistosoma mansoni carbonic anhydrase 0.0027 0.0123 0.0302
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Trypanosoma brucei alpha tubulin 0.028 0.2255 0.7842
Schistosoma mansoni peroxidasin 0.0091 0.0662 0.1622
Trypanosoma cruzi zeta tubulin, putative 0.0085 0.0613 0.2008
Brugia malayi calmodulin 0.0026 0.0116 0.0304
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0047 0.0121
Giardia lamblia Alpha-tubulin 0.028 0.2255 0.7788
Loa Loa (eye worm) animal heme peroxidase 0.0091 0.0662 0.2307
Onchocerca volvulus Peroxidase homolog 0.0091 0.0662 0.4167
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0044 0.0113
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Loa Loa (eye worm) tubulin beta-1 chain 0.0352 0.2862 1
Entamoeba histolytica tubulin alpha-1 chain 0.028 0.2255 0.5523
Trypanosoma cruzi alpha tubulin, putative 0.028 0.2255 0.7842
Trypanosoma brucei alpha tubulin 0.028 0.2255 0.7842
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0613 0.0502
Trypanosoma cruzi tubulin gamma chain 0.0197 0.155 0.5338
Entamoeba histolytica tubulin family protein 0.0352 0.2862 0.7013
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0115
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Trypanosoma brucei beta tubulin 0.0352 0.2862 1
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0226 0.0596
Schistosoma mansoni tyrosine kinase 0.0057 0.0373 0.0915
Echinococcus multilocularis Niemann Pick C1 protein 0.0056 0.0362 0.0648
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0032 0.0163 0.041
Brugia malayi MH2 domain containing protein 0.0138 0.1059 0.2812
Echinococcus granulosus CalModulin family member cmd 1 0.0026 0.0116 0.0202
Echinococcus multilocularis tubulin alpha chain 0.028 0.2255 0.4055
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2255 0.2164
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0957 0.7957 1
Plasmodium vivax tubulin alpha chain, putative 0.028 0.2255 0.7842
Schistosoma mansoni tubulin subunit beta 0.0352 0.2862 0.7014
Loa Loa (eye worm) hypothetical protein 0.0135 0.1032 0.3601
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0056 0.0362 0.0887
Echinococcus granulosus hypothetical protein 0.0683 0.565 1
Trichomonas vaginalis tubulin, putative 0.0352 0.2862 0.2779
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0111 0.0831 0.0723
Plasmodium falciparum calmodulin 0.0026 0.0116 0.0244
Brugia malayi hypothetical protein 0.0091 0.0662 0.1756
Plasmodium falciparum tubulin beta chain 0.0352 0.2862 1
Trypanosoma brucei beta tubulin 0.0352 0.2862 1
Trypanosoma cruzi tubulin delta chain 0.0085 0.0613 0.2008
Echinococcus granulosus tubulin alpha 3 chain 0.028 0.2255 0.3989
Echinococcus granulosus tyrosine kinase 0.0048 0.0299 0.0525
Onchocerca volvulus 0.0026 0.0116 0.072
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.0299 0.0534
Echinococcus granulosus calmodulin 0.0026 0.0116 0.0202
Brugia malayi Tubulin beta chain 0.0085 0.0613 0.1624
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Entamoeba histolytica carbonic anhydrase, putative 0.0497 0.4081 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0197 0.155 0.1451
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0015 0.0021 0.0034
Echinococcus multilocularis tubulin alpha chain 0.028 0.2255 0.4055
Echinococcus multilocularis Tubulin alpha 1 chain 0.028 0.2255 0.4055
Echinococcus granulosus tubulin alpha 1C chain 0.028 0.2255 0.3989
Brugia malayi tubulin alpha chain - mouse 0.028 0.2255 0.5993
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2255 0.2164
Echinococcus multilocularis tyrosine protein kinase HCK 0.0039 0.0222 0.0396
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0123 0.0323
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0085 0.0613 0.0502
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.012 0.0903 0.2398
Echinococcus granulosus tubulin beta 4A class IVa 0.0352 0.2862 0.5065
Giardia lamblia Beta tubulin 0.0352 0.2862 1
Brugia malayi protein-tyrosine kinase 0.0048 0.0299 0.0789
Trypanosoma brucei epsilon tubulin 0.0197 0.155 0.5338
Echinococcus granulosus Tubulin beta 2C chain 0.0352 0.2862 0.5065
Onchocerca volvulus 0.0091 0.0662 0.4167
Echinococcus granulosus tubulin alpha chain 0.028 0.2255 0.3989
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0352 0.2862 0.5148
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0497 0.4081 1
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Schistosoma mansoni tubulin subunit alpha 0.0085 0.0613 0.1501
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0047 0.0081
Brugia malayi Tyrosine-protein kinase abl-1 0.0022 0.0077 0.0199
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0135 0.1032 0.2441
Loa Loa (eye worm) tubulin alpha 2 0.0084 0.0598 0.2083
Echinococcus granulosus tubulin alpha 0.0197 0.155 0.2741
Schistosoma mansoni tubulin subunit beta 0.0352 0.2862 0.7014
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0018 0.0044 0.0148
Plasmodium falciparum tubulin delta chain, putative 0.0085 0.0613 0.2008
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.0299 0.0525
Brugia malayi Putative carbonic anhydrase 5 precursor 0.012 0.0903 0.2398
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1059 0.3695
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Brugia malayi Animal haem peroxidase family protein 0.0091 0.0662 0.1756
Leishmania major gamma-tubulin 0.0197 0.155 0.3725
Schistosoma mansoni growth factor receptor-bound protein 0.0018 0.0044 0.0109
Trypanosoma brucei alpha tubulin, putative 0.0111 0.0831 0.2782
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.012 0.0903 0.3041
Echinococcus multilocularis tubulin alpha 1C chain 0.028 0.2255 0.4055
Giardia lamblia Delta tubulin 0.0085 0.0613 0.1807
Trypanosoma brucei beta tubulin 0.0352 0.2862 1
Schistosoma mansoni hypothetical protein 0.0196 0.1548 0.3793
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0044 0.0113
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0123 0.0323
Plasmodium vivax tubulin epsilon chain, putative 0.0197 0.155 0.5338
Echinococcus multilocularis Tubulin beta 2C chain 0.0352 0.2862 0.5148
Echinococcus granulosus geminin 0.0196 0.1548 0.2737
Echinococcus granulosus GPCR family 2 0.0018 0.0047 0.008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0047 0.0082
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0022 0.0077 0.0132
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Echinococcus multilocularis Tubulin beta 2C chain 0.0352 0.2862 0.5148
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0085 0.0613 0.2008
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0299 0.0534
Loa Loa (eye worm) tubulin alpha 2 0.0195 0.1535 0.5361
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0057 0.0373 0.0657
Schistosoma mansoni tubulin subunit epsilon 0.0197 0.155 0.3798
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0475 0.3892 0.486
Brugia malayi alpha-tubulin 0.028 0.2255 0.5993
Trypanosoma cruzi calmodulin, putative 0.0026 0.0116 0.0244
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0022 0.0077 0.0188
Echinococcus granulosus Tubulin alpha 1 chain 0.028 0.2255 0.3989
Brugia malayi Cell division protein ftsZ 0.0085 0.0613 0.1624
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0047 0.0082
Schistosoma mansoni alpha tubulin 0.028 0.2255 0.5525
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0123 0.0323
Brugia malayi SRC-1 0.0057 0.0373 0.0988
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0085 0.0613 0.5
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0057 0.0373 0.0668
Trypanosoma cruzi zeta tubulin, putative 0.0085 0.0613 0.2008
Echinococcus granulosus NCK adaptor protein 0.0018 0.0044 0.0075
Schistosoma mansoni tyrosine kinase 0.0022 0.0077 0.0188
Echinococcus granulosus calmodulin 0.0026 0.0116 0.0202
Trichomonas vaginalis tubulin alpha chain, putative 0.0352 0.2862 0.2779
Echinococcus multilocularis tyrosine protein kinase Abl 0.0022 0.0077 0.0134
Echinococcus granulosus death domain containing protein 0.0015 0.0021 0.0034
Schistosoma mansoni ankyrin 23/unc44 0.0015 0.0021 0.0052
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0085 0.0613 0.2008
Schistosoma mansoni tyrosine kinase 0.0022 0.0077 0.0188
Echinococcus multilocularis conserved hypothetical protein 0.0673 0.5559 1
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Loa Loa (eye worm) beta-tubulin 0.0352 0.2862 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.038 0.1321
Loa Loa (eye worm) animal heme peroxidase 0.0091 0.0662 0.2307
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Brugia malayi Serotonin receptor 0.0459 0.3761 1
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Echinococcus granulosus Tubulin beta 2C chain 0.0352 0.2862 0.5065
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0022 0.0054
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0057 0.0373 0.0668
Loa Loa (eye worm) TK protein kinase 0.0039 0.0222 0.0769
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0057 0.0373 0.0668
Loa Loa (eye worm) alpha-tubulin 0.028 0.2255 0.7876
Brugia malayi Animal haem peroxidase family protein 0.0091 0.0662 0.1756
Schistosoma mansoni nck2/grb4 0.0018 0.0044 0.0109
Echinococcus multilocularis tubulin delta chain 0.0085 0.0613 0.1099
Echinococcus multilocularis tubulin alpha 1C chain 0.028 0.2255 0.4055
Echinococcus granulosus Tubulin alpha 1 chain 0.028 0.2255 0.3989
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0047 0.0116
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0123 0.0219
Trichomonas vaginalis tubulin gamma chain, putative 0.0197 0.155 0.1451
Echinococcus granulosus Tubulin beta 2C chain 0.0352 0.2862 0.5065
Echinococcus multilocularis hypothetical protein 0.028 0.2255 0.4055
Echinococcus granulosus Niemann Pick C1 protein 0.0056 0.0362 0.0638
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0015 0.0021 0.0067
Trypanosoma brucei zeta tubulin 0.0085 0.0613 0.2008
Trypanosoma brucei alpha tubulin 0.028 0.2255 0.7842
Trypanosoma brucei calmodulin 0.0026 0.0116 0.0244
Trichomonas vaginalis tubulin alpha chain, putative 0.0111 0.0831 0.0723
Mycobacterium ulcerans carbonic anhydrase 0.0497 0.4081 0.3983
Echinococcus multilocularis calmodulin 0.0026 0.0116 0.0206
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0047 0.0082
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2255 0.2164
Brugia malayi Tubulin gamma chain 0.0197 0.155 0.4118
Plasmodium vivax tubulin gamma chain, putative 0.0197 0.155 0.5338
Schistosoma mansoni tubulin subunit alpha 0.028 0.2255 0.5525
Trypanosoma cruzi epsilon tubulin, putative 0.0197 0.155 0.5338
Onchocerca volvulus Chorion peroxidase homolog 0.0091 0.0662 0.4167
Trypanosoma brucei tubulin gamma chain 0.0197 0.155 0.5338
Trypanosoma brucei calmodulin 0.0026 0.0116 0.0244
Schistosoma mansoni carbonic anhydrase 0.0497 0.4081 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0352 0.2862 0.5148
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0047 0.0158
Loa Loa (eye worm) hypothetical protein 0.0056 0.0362 0.1259
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.0299 0.0534
Loa Loa (eye worm) carbonic anhydrase 3 0.012 0.0903 0.3152
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Loa Loa (eye worm) tubulin beta-4 chain 0.0352 0.2862 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.038 0.1321
Brugia malayi Uncoordinated protein 44 0.0015 0.0021 0.0051
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0047 0.012
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0373 0.0668
Schistosoma mansoni tyrosine kinase 0.0057 0.0373 0.0915
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0063 0.0427 0.0315
Brugia malayi Tubulin beta-1 chain 0.0352 0.2862 0.761
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0018 0.0044 0.0148
Echinococcus granulosus tubulin beta 1 chain 0.0352 0.2862 0.5065
Loa Loa (eye worm) hypothetical protein 0.0018 0.0044 0.0148
Onchocerca volvulus Peroxidasin homolog 0.0091 0.0662 0.4167
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2255 0.2164
Echinococcus granulosus Tubulin beta 2C chain 0.0352 0.2862 0.5065
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0015 0.0021 0.0034
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0018 0.0044 0.0109
Leishmania major carbonic anhydrase family protein, putative 0.0497 0.4081 1
Echinococcus granulosus tubulin alpha 1C chain 0.028 0.2255 0.3989
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0115
Trichomonas vaginalis tubulin epsilon chain, putative 0.028 0.2255 0.2164
Toxoplasma gondii beta-tubulin, putative 0.0352 0.2862 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0044 0.0266 0.0468
Schistosoma mansoni tubulin subunit beta 0.0352 0.2862 0.7014
Echinococcus multilocularis tubulin gamma 1 chain 0.0197 0.155 0.2786
Echinococcus multilocularis carbonic anhydrase II 0.012 0.0903 0.1622
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0123 0.0302
Onchocerca volvulus 0.0201 0.1586 1
Echinococcus multilocularis tubulin alpha chain 0.028 0.2255 0.4055
Brugia malayi Tubulin alpha chain 0.0085 0.0613 0.1624
Loa Loa (eye worm) TK protein kinase 0.0048 0.0299 0.1037
Echinococcus granulosus netrin receptor unc 5 0.0015 0.0021 0.0034
Echinococcus granulosus tubulin gamma 1 chain 0.0197 0.155 0.2741
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.0299 0.0525
Plasmodium falciparum tubulin gamma chain 0.0197 0.155 0.5338
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0195 0.1535 0.5361
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0032 0.0163 0.041
Trichomonas vaginalis tubulin, putative 0.0111 0.0831 0.0723
Loa Loa (eye worm) tubulin alpha chain 0.028 0.2255 0.7876
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0056 0.0362 0.1259
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0362 0.0249
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Echinococcus granulosus peroxisome assembly protein 26 0.028 0.2255 0.3989
Echinococcus granulosus tyrosine protein kinase Lyn 0.0057 0.0373 0.0657
Leishmania major alpha tubulin 0.028 0.2255 0.5473
Plasmodium falciparum alpha tubulin 2 0.028 0.2255 0.7842
Echinococcus granulosus tyrosine protein kinase Fyn 0.0057 0.0373 0.0657
Plasmodium vivax tubulin beta chain, putative 0.0352 0.2862 1
Brugia malayi Animal haem peroxidase family protein 0.0091 0.0662 0.1756
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.038 0.1006
Schistosoma mansoni hypothetical protein 0.004 0.0226 0.0553
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0047 0.008
Loa Loa (eye worm) tubulin alpha chain 0.028 0.2255 0.7876
Leishmania major zeta tubulin, putative 0.0085 0.0613 0.1401
Echinococcus multilocularis tubulin alpha 3 chain 0.028 0.2255 0.4055
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0232 0.1849 0.2277
Echinococcus multilocularis protein dispatched 1 0.0056 0.0362 0.0648
Schistosoma mansoni hypothetical protein 0.0196 0.1548 0.3793
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0057 0.0373 0.0668
Plasmodium vivax sulfate transporter, putative 0.0032 0.0163 0.041
Loa Loa (eye worm) tubulin beta-2A chain 0.0352 0.2862 1
Trypanosoma brucei beta tubulin 0.0352 0.2862 1
Giardia lamblia Epsilon tubulin 0.0085 0.0613 0.1807
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0047 0.008
Echinococcus multilocularis tubulin alpha chain 0.028 0.2255 0.4055
Brugia malayi Death domain containing protein 0.0015 0.0021 0.0051
Brugia malayi Peroxidasin 0.0091 0.0662 0.1756
Trichomonas vaginalis tubulin epsilon chain, putative 0.0352 0.2862 0.2779
Trichomonas vaginalis tubulin alpha chain, putative 0.0111 0.0831 0.0723
Echinococcus multilocularis tubulin subunit beta 0.0352 0.2862 0.5148
Trypanosoma brucei tubulin delta chain 0.0085 0.0613 0.2008
Plasmodium vivax delta tubulin, putative 0.0085 0.0613 0.2008
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.012 0.0903 0.3041
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Trichomonas vaginalis tubulin epsilon chain, putative 0.0352 0.2862 0.2779
Brugia malayi Blistered cuticle protein 3 0.0091 0.0662 0.1756
Loa Loa (eye worm) tubulin beta chain 0.0085 0.0613 0.2135
Echinococcus multilocularis calmodulin 0.0026 0.0116 0.0206
Echinococcus multilocularis tubulin alpha chain 0.028 0.2255 0.4055
Brugia malayi Tubulin beta chain 0.0111 0.0831 0.2205
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0425
Echinococcus multilocularis calmodulin 0.0026 0.0116 0.0206
Trypanosoma brucei beta tubulin 0.0197 0.155 0.5338
Brugia malayi Tubulin alpha-2 chain 0.028 0.2255 0.5993
Plasmodium falciparum tubulin epsilon chain, putative 0.0197 0.155 0.5338
Trypanosoma brucei calmodulin 0.0026 0.0116 0.0244
Echinococcus granulosus Tubulin beta 2C chain 0.0352 0.2862 0.5065
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0135 0.1032 0.3498
Trichomonas vaginalis tubulin beta chain, putative 0.0352 0.2862 0.2779
Leishmania major beta tubulin 0.0352 0.2862 0.6979
Trichomonas vaginalis tubulin beta chain, putative 0.028 0.2255 0.2164
Onchocerca volvulus Netrin receptor homolog 0.0015 0.0021 0.0121
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.038 0.1006
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0047 0.008
Brugia malayi beta-tubulin, identical 0.0352 0.2862 0.761
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0115
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Plasmodium vivax calmodulin, putative 0.0026 0.0116 0.0244
Echinococcus granulosus tyrosine protein kinase Src42A 0.0057 0.0373 0.0657
Mycobacterium leprae Probable transmembrane transport protein 0.0232 0.1849 0.3564
Loa Loa (eye worm) hypothetical protein 0.0195 0.1535 0.5361
Brugia malayi isocitrate dehydrogenase 0.0018 0.0047 0.0121
Trypanosoma cruzi calmodulin 0.0026 0.0116 0.0244
Echinococcus multilocularis calmodulin 0.0026 0.0116 0.0206
Trichomonas vaginalis tubulin gamma chain, putative 0.0352 0.2862 0.2779
Echinococcus multilocularis tubulin epsilon chain 0.0197 0.155 0.2786
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1059 0.3695
Giardia lamblia Gamma tubulin 0.0197 0.155 0.5221
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0047 0.0082
Schistosoma mansoni alpha tubulin 0.028 0.2255 0.5525
Loa Loa (eye worm) hypothetical protein 0.028 0.2255 0.7876
Trichomonas vaginalis tubulin epsilon chain, putative 0.0085 0.0613 0.0502
Echinococcus multilocularis tubulin alpha 0.0197 0.155 0.2786
Echinococcus multilocularis CalModulin family member (cmd 1) 0.0026 0.0116 0.0206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0425
Echinococcus granulosus beta tubulin 0.0352 0.2862 0.5065
Echinococcus granulosus Protein patched homolog 1 0.0056 0.0362 0.0638
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0071
Echinococcus granulosus calmodulin 0.0026 0.0116 0.0202
Loa Loa (eye worm) animal heme peroxidase 0.0091 0.0662 0.2307
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0057 0.0373 0.0668
Echinococcus granulosus tyrosine protein kinase Src64B 0.0057 0.0373 0.0657
Echinococcus granulosus tubulin epsilon chain 0.0197 0.155 0.2741
Toxoplasma gondii calmodulin, putative 0.0026 0.0116 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0399
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0123 0.0302
Loa Loa (eye worm) blistered cuticle protein 3 0.0091 0.0662 0.2307
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0022 0.0077 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.12 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.012 0.0903 0.2214
Echinococcus granulosus tubulin delta chain 0.0085 0.0613 0.1081
Trichomonas vaginalis tubulin epsilon chain, putative 0.028 0.2255 0.2164
Loa Loa (eye worm) animal heme peroxidase 0.0091 0.0662 0.2307
Loa Loa (eye worm) hypothetical protein 0.0027 0.0123 0.0425
Loa Loa (eye worm) tubulin alpha 2 0.0195 0.1535 0.5361
Loa Loa (eye worm) tubulin beta chain 0.0352 0.2862 1
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0123 0.0302
Trypanosoma cruzi calmodulin 0.0026 0.0116 0.0244
Schistosoma mansoni tyrosine kinase 0.0013 0.0002 0.0005
Loa Loa (eye worm) hypothetical protein 0.0091 0.0662 0.2307
Onchocerca volvulus 0.0091 0.0662 0.4167
Echinococcus granulosus tubulin alpha chain 0.028 0.2255 0.3989
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0067
Echinococcus granulosus tubulin alpha chain 0.028 0.2255 0.3989
Trypanosoma cruzi tubulin delta chain 0.0085 0.0613 0.2008
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0057 0.0373 0.0668
Echinococcus granulosus carbonic anhydrase II 0.012 0.0903 0.1596
Brugia malayi Animal haem peroxidase family protein 0.0091 0.0662 0.1756
Schistosoma mansoni adapter molecule crk 0.0018 0.0044 0.0109
Echinococcus multilocularis NCK adaptor protein 0.0018 0.0044 0.0076
Loa Loa (eye worm) tubulin alpha-3 chain 0.0169 0.1317 0.4598

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) 0 uM Inhibition of Vascular endothelial growth factor receptor 2(Not tested) ChEMBL. 12039590
IC50 (binding) = 0.046 uM Inhibition of human p56 Lck tyrosine kinase (lck64-509) ChEMBL. 12039590
IC50 (binding) = 0.046 uM Inhibition of human p56 Lck tyrosine kinase (lck64-509) ChEMBL. 12039590
IC50 (binding) = 0.39 uM Inhibition of Src protein tryrosine kinase ChEMBL. 12039590
IC50 (binding) = 0.39 uM Inhibition of Src protein tryrosine kinase ChEMBL. 12039590
IC50 (binding) = 6.62 uM Inhibition of TIE-2 kinase ChEMBL. 12039590
IC50 (binding) = 6.62 uM Inhibition of TIE-2 kinase ChEMBL. 12039590

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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