Detailed information for compound 650422

Basic information

Technical information
  • TDR Targets ID: 650422
  • Name: 2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(4-hydro xyphenyl)acetamide
  • MW: 266.273 | Formula: C11H10N2O4S
  • H donors: 3 H acceptors: 4 LogP: 0.56 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)O)CC1SC(=O)NC1=O
  • InChi: 1S/C11H10N2O4S/c14-7-3-1-6(2-4-7)12-9(15)5-8-10(16)13-11(17)18-8/h1-4,8,14H,5H2,(H,12,15)(H,13,16,17)
  • InChiKey: IHPXMKNPTRCHGC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2,4-dioxothiazolidin-5-yl)-N-(4-hydroxyphenyl)acetamide
  • 2-(2,4-dioxo-5-thiazolidinyl)-N-(4-hydroxyphenyl)acetamide
  • 2-(2,4-diketothiazolidin-5-yl)-N-(4-hydroxyphenyl)acetamide
  • 2-(2,4-dioxo-1,3-thiazolidin-5-yl)-N-(4-hydroxyphenyl)ethanamide
  • Oprea1_653036
  • ChemDiv2_004113
  • ST5054965
  • Oprea1_796435
  • IDI1_002828
  • EU-0076722

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0162 0.0613
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0097 0.0164 0.0581
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0072 0.0703
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0072 0.0112 0.0439
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0112 0.0399
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.0366 0.1422
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0063 0.0223
Loa Loa (eye worm) hypothetical protein 0.0151 0.0275 0.1084
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0063 0.0215
Brugia malayi RNA binding protein 0.0259 0.0498 0.1948
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0096 0.0162 0.0576
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0219 0.0414 0.1471
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0076 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0038 0.0117
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.1245 0.2519 0.8952
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.0075 0.1645
Echinococcus granulosus importin subunit beta 1 0.0028 0.0024 0.0085
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.0537 0.1909
Schistosoma mansoni hypothetical protein 0.0288 0.0556 0.1977
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0069 0.0246
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0498 0.1768
Trypanosoma brucei mitochondrial DNA polymerase beta 0.061 0.1215 1
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0498 0.1768
Echinococcus granulosus apoptotic protease activating factor 1 0.0369 0.0723 0.2568
Echinococcus granulosus expressed conserved protein 0.0183 0.0341 0.1213
Leishmania major importin beta-1 subunit, putative 0.0023 0.0013 0.0036
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Loa Loa (eye worm) hypothetical protein 0.0047 0.0063 0.0242
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.0348 0.1238
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0091 0.0324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0069 0.0246
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0189 0.0189
Brugia malayi TAR-binding protein 0.0259 0.0498 0.1948
Echinococcus multilocularis protein dispatched 1 0.0096 0.0161 0.0161
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0009 0.0002
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.001 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Trichomonas vaginalis glucosylceramidase, putative 0.0355 0.0693 0.681
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0122 0.0216 0.0767
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0097 0.0164 0.0581
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0063 0.0242
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.001 0.0004
Entamoeba histolytica hypothetical protein 0.0023 0.0013 0.0123
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0009 0.003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0002 0.0006
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0021 0.001 0.0031
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0009 0.003
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0096 0.0162 0.0576
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0021 0.001 0.001
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0112 0.0399
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Loa Loa (eye worm) TAR-binding protein 0.0259 0.0498 0.197
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0009 0.003
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.1389 0.2814 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0076 0.027
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Echinococcus granulosus zinc finger protein 0.002 0.0007 0.0025
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0002 0.0006
Loa Loa (eye worm) ACC-1 protein 0.0021 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0123 0.0218 0.0858
Schistosoma mansoni hypothetical protein 0.1245 0.2519 0.8952
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0071 0.0251
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0219 0.0414 0.1471
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.001 0.0004
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0013 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0162 0.0575
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.061 0.1215 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.001 0.0034
Echinococcus multilocularis snurportin 1 0.0304 0.0589 0.0589
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.0961 0.1936 0.6879
Trypanosoma brucei protein kinase, putative 0.0052 0.0072 0.0523
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0219 0.0414 0.3358
Loa Loa (eye worm) hypothetical protein 0.0028 0.0024 0.0088
Onchocerca volvulus 0.0025 0.0017 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0002 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Brugia malayi mbt repeat family protein 0.0047 0.0063 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0249 0.0886
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0112 0.0399
Mycobacterium ulcerans AcrR family transcriptional regulator 0.1389 0.2814 1
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0009 0.0027
Schistosoma mansoni microtubule-associated protein tau 0.1389 0.2814 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0021 0.001 0.001
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0009 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0009 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Echinococcus multilocularis acetylcholinesterase 0.0041 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0195 0.0366 0.1445
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0013 0.0048
Echinococcus granulosus geminin 0.0358 0.07 0.2489
Onchocerca volvulus 0.0021 0.001 0.0004
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0076 0.027
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.1018 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0027
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0189 0.067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0112 0.0399
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0096 0.0162 0.0162
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0021 0.001 0.0004
Echinococcus multilocularis carboxylesterase 5A 0.0041 0.005 0.005
Schistosoma mansoni patched 1 0.0084 0.0137 0.0487
Brugia malayi GMP reductase 0.0097 0.0164 0.0618
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0009 0.003
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0009 0.003
Schistosoma mansoni ran 0.0021 0.0008 0.003
Brugia malayi RNA recognition motif domain containing protein 0.0259 0.0498 0.1948
Onchocerca volvulus Deterin homolog 0.1245 0.2519 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.001 0.0004
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0137 0.0538
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0027
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0071 0.0277
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0072 0.0523
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0288 0.0557 0.4545
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0513 0.1018 0.4037
Entamoeba histolytica hypothetical protein 0.0109 0.0189 0.5044
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0003 0.0009
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.001 0.001
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0009 0.003
Loa Loa (eye worm) IMP dehydrogenase 1 0.0219 0.0414 0.1637
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.1245 0.2519 0.2519
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0076 0.027
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0021 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.1245 0.2519 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0021 0.001 0.0031
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0021 0.001 0.0034
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0091 0.0091
Onchocerca volvulus 0.0369 0.0723 0.2844
Echinococcus multilocularis expressed conserved protein 0.0183 0.0341 0.0341
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0219 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0042 0.0052 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0072 0.0254
Schistosoma mansoni hypothetical protein 0.0035 0.0038 0.0135
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.001 0.0004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0091 0.0324
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0072 0.0523
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0288 0.0557 0.4545
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Schistosoma mansoni hypothetical protein 0.0369 0.0723 0.2568
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0009 0.003
Echinococcus granulosus microtubule associated protein 2 0.1389 0.2814 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0009 0.003
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.001 0.001
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0072 0.4111
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0002 0.0002
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0024 0.0024
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0162 0.1271
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0112 0.2906
Echinococcus granulosus baculoviral IAP repeat containing protein 0.1245 0.2519 0.8952
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0112 0.0399
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0498 0.1768
Leishmania major inosine-5-monophosphate dehydrogenase 0.0219 0.0414 0.3358
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0219 0.0414 0.1614
Echinococcus granulosus muscleblind protein 0.0151 0.0275 0.0976
Brugia malayi Bromodomain containing protein 0.0078 0.0125 0.0464
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0009 0.003
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0009 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.1018 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0009 0.0001
Echinococcus granulosus acetylcholinesterase 0.0041 0.005 0.0178
Echinococcus multilocularis apoptotic protease activating factor 1 0.0369 0.0723 0.0723
Onchocerca volvulus 0.0021 0.001 0.0004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0009 0.003
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0002 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0009 0.003
Echinococcus multilocularis zinc finger protein 0.002 0.0007 0.0007
Treponema pallidum bacterioferrin (TpF1) 0.0017 0 0.5
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0072 0.0112 0.0439
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0003 0.0005
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0072 0.0523
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.001 0.0004
Onchocerca volvulus 0.0021 0.001 0.0004
Brugia malayi PHD-finger family protein 0.0026 0.0018 0.004
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0042 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0072 0.0703
Loa Loa (eye worm) hypothetical protein 0.0053 0.0075 0.0292
Onchocerca volvulus 0.0021 0.001 0.0004
Schistosoma mansoni hypothetical protein 0.0081 0.0131 0.0465
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0008 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0249 0.0983
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.001 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.0075 0.0267
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0112 0.0399
Loa Loa (eye worm) hypothetical protein 0.0053 0.0075 0.0292
Mycobacterium ulcerans transcriptional regulator 0.1389 0.2814 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0112 0.0439
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.1018 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0063 0.0223
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0021 0.001 0.0004
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.0537 0.0537
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0096 0.0162 0.0162
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0009 0.0001
Echinococcus multilocularis microtubule associated protein 2 0.1389 0.2814 0.2814
Schistosoma mansoni caspase-7 (C14 family) 0.0369 0.0723 0.2568
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0013 0.0126
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0009 0.003
Leishmania major mitochondrial DNA polymerase beta 0.061 0.1215 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.0372 0.1321
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0071 0.0251
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0091 0.0324
Brugia malayi mbt repeat family protein 0.0047 0.0063 0.0216
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0009 0.003
Entamoeba histolytica hypothetical protein 0.0109 0.0189 0.5044
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0112 0.0399
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0219 0.0414 0.1471
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1245 0.2519 1
Echinococcus granulosus inhibitor of apoptosis protein 0.1245 0.2519 0.8952
Echinococcus granulosus tar DNA binding protein 0.0259 0.0498 0.1768
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.001 0.0034
Schistosoma mansoni survival motor neuron protein 0.0096 0.0162 0.0577
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0498 0.1768
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0072 0.0523
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0112 0.086
Schistosoma mansoni hypothetical protein 0.0081 0.0131 0.0465
Brugia malayi Cell death protein 3 precursor 0.0369 0.0723 0.2845
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0072 0.0523
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0162 0.1271
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0175 0.0324 0.115
Loa Loa (eye worm) acetylcholinesterase 1 0.0041 0.005 0.0192
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0219 0.0414 0.3358
Brugia malayi hypothetical protein 0.0471 0.0931 0.3673
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0249 0.0249
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.0126
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0021 0.001 0.0034
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0162 0.0575
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0112 0.086
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.0366 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0096 0.0162 0.0637
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0002 0.0006
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0288 0.0557 0.4545
Loa Loa (eye worm) hypothetical protein 0.0369 0.0723 0.2864
Onchocerca volvulus Glucosylceramidase homolog 0.0337 0.0656 0.2579
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0091 0.0685
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0137 0.1347
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0063 0.0621
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0189 0.067
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0072 0.0254
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0076 0.0295
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0009 0.0001
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Plasmodium vivax importin-beta 2, putative 0.0028 0.0024 0.0381
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0091 0.0324
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0009 0.0084
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0021 0.001 0.0004
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0009 0.0001
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0112 0.0399
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0141 0.11
Echinococcus multilocularis acetylcholinesterase 0.0041 0.005 0.005
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0097 0.0164 0.0618
Onchocerca volvulus 0.0096 0.0162 0.0612
Echinococcus granulosus glycine receptor subunit beta 0.0021 0.001 0.0034
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.0075 0.5
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0009 0.003
Echinococcus multilocularis geminin 0.0358 0.07 0.07
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.0931 0.3307
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0009 0.0001
Echinococcus multilocularis muscleblind protein 1 0.0151 0.0275 0.0275
Echinococcus multilocularis tar DNA binding protein 0.0259 0.0498 0.0498
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.0931 0.0931
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0219 0.0414 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0112 0.0399
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.0366 0.1299
Echinococcus multilocularis muscleblind protein 0.0151 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Loa Loa (eye worm) RNA binding protein 0.0259 0.0498 0.197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0069 0.0246
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0112 0.0413
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0072 0.0703
Brugia malayi MAP kinase sur-1 0.0052 0.0072 0.0251
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0021 0.001 0.001
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0009 0.0002
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0009 0.0003
Loa Loa (eye worm) hypothetical protein 0.0044 0.0056 0.0216
Schistosoma mansoni hypothetical protein 0.0358 0.07 0.2489
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0092 0.0329
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0063 0.0063
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0009 0.003
Brugia malayi Cation transporter family protein 0.0021 0.001 0.0004
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0013 0.0126
Onchocerca volvulus 0.0021 0.001 0.0004
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0219 0.0414 0.3358
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0009 0.0002
Brugia malayi Muscleblind-like protein 0.0151 0.0275 0.106
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0192
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.001 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0219 0.0414 0.3358
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.1018 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0072 0.0523
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0104 0.018 0.1418
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Giardia lamblia Kinase, PLK 0.0096 0.0162 1
Brugia malayi Cation transporter family protein 0.0021 0.001 0.0004
Loa Loa (eye worm) GMP reductase 0.0097 0.0164 0.0643
Onchocerca volvulus Putative GMP reductase 0.0097 0.0164 0.0617
Trichomonas vaginalis glucosylceramidase, putative 0.0513 0.1018 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0021 0.001 0.0031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.005 0.0178
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.0348 0.0348
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.001 0.001
Loa Loa (eye worm) MBCTL1 0.0054 0.0076 0.0295
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0042 0.0042
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0096 0.0162 0.0612
Onchocerca volvulus Putative nachr subunit 0.0096 0.0162 0.0612
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0112 0.086
Brugia malayi Carboxylesterase family protein 0.0041 0.005 0.0166
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0021 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0084 0.0137 0.0538
Schistosoma mansoni kinase 0.0049 0.0066 0.0234
Echinococcus multilocularis inhibitor of apoptosis protein 0.1245 0.2519 0.2519
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0091 0.0324
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Echinococcus multilocularis protein patched 0.0084 0.0137 0.0137
Onchocerca volvulus Huntingtin homolog 0.0123 0.0218 0.0833
Schistosoma mansoni zinc finger protein 0.002 0.0007 0.0025
Trypanosoma brucei GMP reductase 0.0219 0.0414 0.3358
Brugia malayi CHE-14 protein 0.0084 0.0137 0.0513
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0009 0.003
Onchocerca volvulus 0.0047 0.0063 0.0215
Loa Loa (eye worm) hypothetical protein 0.0103 0.0176 0.0691
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0162 0.0636
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0091 0.0324
Loa Loa (eye worm) hypothetical protein 0.0035 0.0038 0.0144
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0063 0.0621
Loa Loa (eye worm) hypothetical protein 0.0369 0.0723 0.2864
Plasmodium falciparum importin beta, putative 0.0028 0.0024 0.0381
Loa Loa (eye worm) ACC-1 protein 0.0021 0.001 0.0031
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1245 0.2519 1
Brugia malayi Bromodomain containing protein 0.004 0.0047 0.0153
Brugia malayi Importin beta-1 subunit 0.0028 0.0024 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0249 0.0886
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0009 0.0001
Schistosoma mansoni hypothetical protein 0.0021 0.0009 0.0033
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0021 0.001 0.0031
Schistosoma mansoni importin beta-1 0.0028 0.0024 0.0085
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0072 0.0523
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0112 0.2906
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0109 0.0189 0.067
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0021 0.001 0.0034
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.0075 0.0267
Brugia malayi hypothetical protein 0.0109 0.0189 0.0717
Trichomonas vaginalis glucosylceramidase, putative 0.0355 0.0693 0.681
Echinococcus multilocularis caspase 2 0.0369 0.0723 0.0723
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0063 0.0063
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0009 0.003
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0122 0.0216 0.0767
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.001 0.0034
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0008 0.0008
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0076 0.0076
Brugia malayi RNA, U transporter 1 0.0081 0.0132 0.049
Schistosoma mansoni hypothetical protein 0.0304 0.0589 0.2094
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0013 0.0048
Loa Loa (eye worm) hypothetical protein 0.0053 0.0075 0.0292
Loa Loa (eye worm) LGC-31 protein 0.0021 0.001 0.0031
Entamoeba histolytica hypothetical protein 0.0109 0.0189 0.5044
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0259 0.0498 0.197
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Toxoplasma gondii hypothetical protein 0.0098 0.0167 0.3913
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0091 0.2039
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.061 0.1215 1
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.0075 0.1645
Schistosoma mansoni bromodomain containing protein 0.0066 0.01 0.0356
Brugia malayi hypothetical protein 0.0123 0.0218 0.0833
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Echinococcus granulosus nAChR subunit 0.0021 0.001 0.0034
Mycobacterium ulcerans hypothetical protein 0.0321 0.0624 0.2217
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.0366 0.0366
Onchocerca volvulus 0.0021 0.001 0.0004
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Schistosoma mansoni hypothetical protein 0.0358 0.07 0.2489
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0063 0.0223
Onchocerca volvulus Huntingtin homolog 0.0123 0.0218 0.0833
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0219 0.0414 0.147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0249 0.0886
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0009 0.003
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0002 0.0006
Schistosoma mansoni hypothetical protein 0.0096 0.0162 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0021 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Loa Loa (eye worm) hypothetical protein 0.0052 0.0071 0.0277
Echinococcus granulosus snurportin 1 0.0304 0.0589 0.2094
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0141 0.11
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0024 0.0128
Mycobacterium ulcerans TetR family transcriptional regulator 0.1389 0.2814 1
Loa Loa (eye worm) carboxylesterase 0.0041 0.005 0.0192
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0219 0.0414 1
Mycobacterium ulcerans hypothetical protein 0.0072 0.0112 0.0399
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0021 0.001 0.001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0072 0.1556
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0096 0.0162 0.0576
Entamoeba histolytica hypothetical protein 0.0109 0.0189 0.5044
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0009 0.003
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0009 0.0027
Mycobacterium tuberculosis Conserved hypothetical protein 0.0321 0.0624 0.2217
Schistosoma mansoni inhibitor of apoptosis protein 0.1245 0.2519 0.8952
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0041 0.005 0.0192
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0021 0.001 0.0034
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0009 0.003
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0137 0.0487
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0219 0.0414 0.147
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0021 0.001 0.0034
Echinococcus granulosus carboxylesterase 5A 0.0041 0.005 0.0178
Schistosoma mansoni ran 0.0021 0.0008 0.003
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0009 0.0001
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Leishmania major guanosine monophosphate reductase 0.0219 0.0414 0.3358
Trichomonas vaginalis ran, putative 0.0021 0.0008 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0021 0.001 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.001 0.0004
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0024 0.0381
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0112 0.2906
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0063 0.0223
Echinococcus multilocularis nAChR subunit 0.0021 0.001 0.001
Toxoplasma gondii IMP dehydrogenas 0.0219 0.0414 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0075 0.0292
Onchocerca volvulus Cell death protein 3 homolog 0.0369 0.0723 0.2844
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0471 0.0931 0.3689
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0112 0.0399
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0069 0.0246
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0072 0.0703
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0513 0.1018 0.4021
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0137 0.0487
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.1389 0.2814 1
Trichomonas vaginalis glucosylceramidase, putative 0.0337 0.0656 0.6445
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0024 0.0128
Brugia malayi Cation transporter family protein 0.0021 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0072 0.0277
Trypanosoma cruzi GMP reductase 0.0219 0.0414 0.3358
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0162 0.159
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0063 0.0223
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0021 0.001 0.0034
Loa Loa (eye worm) hypothetical protein 0.0053 0.0075 0.0292
Brugia malayi hypothetical protein 0.0369 0.0723 0.2845
Loa Loa (eye worm) hypothetical protein 0.004 0.0047 0.018
Schistosoma mansoni tar DNA-binding protein 0.0259 0.0498 0.1768
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0072 0.0254
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0249 0.0886
Loa Loa (eye worm) hypothetical protein 0.0151 0.0275 0.1084
Echinococcus multilocularis glycine receptor subunit beta 0.0021 0.001 0.001
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0162 0.0611
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0249 0.0249
Echinococcus granulosus caspase 2 0.0369 0.0723 0.2568
Loa Loa (eye worm) hypothetical protein 0.0073 0.0116 0.0453
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0097 0.0164 0.0618
Schistosoma mansoni hypothetical protein 0.0081 0.0131 0.0465
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0009 0.0009
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0219 0.0414 0.1471
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0027
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0249 0.0959
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0076 0.0269
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0086 0.0141 0.11
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0112 0.0399
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0009 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0249 0.0886
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0091 0.0324
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.0009 0.003
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0086 0.0141 0.11
Loa Loa (eye worm) oxidoreductase 0.0021 0.0009 0.0027
Trypanosoma brucei polo-like protein kinase 0.0096 0.0162 0.1271
Trypanosoma cruzi GMP reductase 0.0219 0.0414 0.3358
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.001 0.001
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0021 0.001 0.0004
Brugia malayi Carboxylesterase family protein 0.0041 0.005 0.0166
Loa Loa (eye worm) hypothetical protein 0.0096 0.0162 0.0637
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0096 0.0162 0.0162
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.1245 0.2519 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0021 0.001 0.0034
Brugia malayi excitatory GABA receptor EXP-1A 0.0021 0.001 0.0004
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0009 0.0001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0162 0.1271
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0002 0.0006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0009 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0031
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0021 0.001 0.0004
Onchocerca volvulus 0.0072 0.0112 0.0413
Schistosoma mansoni nAChR subunit 0.0021 0.001 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0112 0.0413
Loa Loa (eye worm) hypothetical protein 0.0123 0.0218 0.0858
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.0589 0.2333
Echinococcus granulosus glycine receptor subunit alpha 1 0.0021 0.001 0.0034
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0013 0.0036
Onchocerca volvulus 0.1245 0.2519 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0021 0.001 0.0004
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0162 0.4297
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0162 0.0611
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0021 0.001 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0112 0.0413
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.0081 0.0131 0.0465
Echinococcus granulosus acetylcholinesterase 0.0041 0.005 0.0178
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0219 0.0414 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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