Detailed information for compound 657419

Basic information

Technical information
  • TDR Targets ID: 657419
  • Name: ethyl 5-[(4-bromophenyl)sulfonylamino]-7-chlo ro-2-methyl-1-benzofuran-3-carboxylate
  • MW: 472.737 | Formula: C18H15BrClNO5S
  • H donors: 1 H acceptors: 3 LogP: 4.79 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(C)oc2c1cc(cc2Cl)NS(=O)(=O)c1ccc(cc1)Br
  • InChi: 1S/C18H15BrClNO5S/c1-3-25-18(22)16-10(2)26-17-14(16)8-12(9-15(17)20)21-27(23,24)13-6-4-11(19)5-7-13/h4-9,21H,3H2,1-2H3
  • InChiKey: RBNMIDNCEKUQFO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 5-[(4-bromophenyl)sulfonylamino]-7-chloro-2-methyl-benzofuran-3-carboxylate
  • 5-[(4-bromophenyl)sulfonylamino]-7-chloro-2-methyl-3-benzofurancarboxylic acid ethyl ester
  • 5-[(4-bromophenyl)sulfonylamino]-7-chloro-2-methyl-benzofuran-3-carboxylic acid ethyl ester
  • ChemDivAM_000064
  • EU-0074317
  • ChemDiv1_006565
  • ZINC00944070

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Probable ClpP-like protease 0.0156 0.0225 0.1992
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0048 0.0056 0.0502
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.002 0.0013 0.0018
Echinococcus granulosus smad 0.0016 0.0006 0.0005
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0029
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0009 0.0078
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0077 0.0101 0.3006
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0101 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.002 0.0183
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.002 0.0013 0.0273
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0175 0.0174
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0075 0.0071
Leishmania major NADH dehydrogenase, putative 0.002 0.0013 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0049 0.1347
Toxoplasma gondii selenide, water dikinase 0.002 0.0013 0.0241
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0026 0.065
Loa Loa (eye worm) Smad1 0.0016 0.0006 0.0055
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2106 0.3282 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0011 0.0014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0011 0.0014
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0005 0.0004
Plasmodium falciparum glutathione reductase 0.0077 0.0101 0.2976
Echinococcus granulosus mitogen activated protein kinase 3 0.0048 0.0056 0.0055
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.002 0.0013 0.0012
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0029
Loa Loa (eye worm) hypothetical protein 0.019 0.0279 0.25
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.0296 0.2652
Brugia malayi beta-lactamase 0.0077 0.0101 0.0883
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0024 0.0052
Echinococcus granulosus phd:f box containing protein 0.0015 0.0005 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0011 0.0014
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.0141 0.014
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0005 0.0004
Entamoeba histolytica hypothetical protein 0.011 0.0153 0.9526
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0101 0.0287
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0009 0.0168
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0049 0.044
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0013 0.0012
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0013 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0025 0.002 0.0017
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0005 0.0004
Plasmodium falciparum thioredoxin reductase 0.0077 0.0101 0.2976
Brugia malayi MH2 domain containing protein 0.0016 0.0006 0.0029
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0013 0.0288
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0013 0.0272
Echinococcus multilocularis smad 0.0016 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0167 0.0242 0.0238
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0101 0.297
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0013 0.0241
Schistosoma mansoni hypothetical protein 0.0024 0.0018 0.0014
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.002 0.0013 0.0018
Brugia malayi ecdysteroid receptor 0.0025 0.002 0.0157
Mycobacterium ulcerans dehydrogenase 0.002 0.0013 0.0018
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0013 0.0012
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.002 0.0157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0116 0.0163 0.0159
Loa Loa (eye worm) hypothetical protein 0.013 0.0185 0.1655
Echinococcus granulosus glutamate synthase 0.002 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0049 0.1393
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.006 0.0075 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0022
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0051
Echinococcus multilocularis GPCR, family 2 0.006 0.0075 0.0075
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0058 0.0518
Echinococcus multilocularis thioredoxin glutathione reductase 0.0223 0.033 0.0329
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0222 0.0328 0.0981
Loa Loa (eye worm) hypothetical protein 0.0053 0.0064 0.0573
Schistosoma mansoni hypothetical protein 0.0167 0.0242 0.0238
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0101 0.0906
Mycobacterium ulcerans TetR family transcriptional regulator 0.211 0.3289 1
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.0349 0.3128
Toxoplasma gondii exonuclease III APE 0.0018 0.0009 0.0109
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0058 0.0057
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.0013 0.0018
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.002 0.0013 0.0282
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0013 0.0248
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0077 0.0101 0.3006
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0035 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.002 0.0157
Brugia malayi hypothetical protein 0.0725 0.1117 1
Echinococcus granulosus Niemann Pick C1 protein 0.0163 0.0237 0.0236
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0114 0.016 0.1433
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Echinococcus granulosus intermediate filament protein 0.0026 0.0022 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.002 0.002
Schistosoma mansoni coup transcription factor 0.0025 0.002 0.0017
Echinococcus granulosus FTZ F1 alpha 0.0025 0.002 0.002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.002 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0035 0.0932
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.002 0.0017
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0013 0.0272
Echinococcus granulosus tar DNA binding protein 0.0062 0.0079 0.0078
Toxoplasma gondii ABC1 family protein 0.0077 0.0101 0.297
Loa Loa (eye worm) thioredoxin reductase 0.0222 0.0328 0.2941
Echinococcus granulosus sulfide:quinone oxidoreductase 0.002 0.0013 0.0012
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Treponema pallidum NADH oxidase 0.0077 0.0101 0.4334
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Schistosoma mansoni lamin 0.0026 0.0022 0.0018
Brugia malayi intermediate filament protein 0.0026 0.0022 0.017
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0009 0.015
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0013 0.0241
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.002 0.0013 0.0018
Loa Loa (eye worm) RNA binding protein 0.0062 0.0079 0.0704
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0065 0.185
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0101 0.0288
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.002 0.0013 0.0018
Entamoeba histolytica hypothetical protein 0.011 0.0153 0.9526
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0072 0.0071
Brugia malayi hypothetical protein 0.0016 0.0006 0.0025
Mycobacterium tuberculosis Conserved protein 0.0077 0.0101 0.0288
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0005 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0119
Schistosoma mansoni hypothetical protein 0.006 0.0075 0.0072
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0077 0.0101 0.0885
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0013 0.0282
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.002 0.0013 0.0012
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.002 0.0013 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0415
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0235
Echinococcus multilocularis expressed protein 0.0017 0.0007 0.0006
Giardia lamblia GTOR 0.0043 0.0049 0.4354
Loa Loa (eye worm) beta-lactamase 0.0077 0.0101 0.0906
Echinococcus granulosus ferritin 0.0017 0.0007 0.0006
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0153 0.0149
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0056 0.1554
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0148 0.0213 0.1883
Brugia malayi nuclear receptor RXR 0.0016 0.0006 0.0025
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.002 0.0013 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Trypanosoma cruzi trypanothione reductase, putative 0.0222 0.0328 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0064 0.1852
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.002 0.0157
Brugia malayi MAP kinase sur-1 0.0048 0.0056 0.0477
Loa Loa (eye worm) hypothetical protein 0.0077 0.0101 0.0906
Mycobacterium ulcerans glutamate synthase subunit beta 0.002 0.0013 0.0018
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.002 0.0013 0.0012
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0101 0.2999
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0013 0.0281
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0119
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0018 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0075 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.002 0.0183
Giardia lamblia Thioredoxin reductase 0.002 0.0013 0.046
Toxoplasma gondii NADPH-glutathione reductase 0.0077 0.0101 0.2976
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.002 0.002
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.0225 0.0664
Loa Loa (eye worm) hypothetical protein 0.006 0.0075 0.0673
Schistosoma mansoni hypothetical protein 0.0124 0.0175 0.0171
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0072 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0079 0.0075
Schistosoma mansoni Smad4 0.0016 0.0006 0.0002
Brugia malayi hypothetical protein 0.0034 0.0035 0.0284
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.002 0.0013 0.046
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0075 0.0206
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.002 0.0227
Onchocerca volvulus 0.0077 0.0101 0.27
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.002 0.002
Mycobacterium tuberculosis Probable dehydrogenase 0.0506 0.0773 0.234
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0101 0.2899
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0024 0.0052
Leishmania major hypothetical protein, conserved 0.002 0.0013 0.0281
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.016 0.0159
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.002 0.0157
Loa Loa (eye worm) programmed cell death 8 0.002 0.0013 0.0116
Brugia malayi hypothetical protein 0.0016 0.0006 0.0025
Echinococcus multilocularis Smad4 0.0016 0.0006 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0022 0.0531
Brugia malayi MH1 domain containing protein 0.0016 0.0006 0.0029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0022 0.0531
Loa Loa (eye worm) hypothetical protein 0.0077 0.0101 0.0906
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0077 0.0101 0.4334
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0039 0.105
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0013 0.0272
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0024 0.0191
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0024 0.0052
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.002 0.002
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0506 0.0773 0.2336
Mycobacterium ulcerans ferredoxin reductase 0.002 0.0013 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.002 0.0183
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0021
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.0225 0.0221
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0519
Onchocerca volvulus 0.0077 0.0101 0.27
Onchocerca volvulus 0.0229 0.034 1
Loa Loa (eye worm) hypothetical protein 0.0206 0.0303 0.2718
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0018 0.0017
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0058 0.0057
Schistosoma mansoni ferritin 0.0017 0.0007 0.0003
Mycobacterium tuberculosis Conserved protein 0.0077 0.0101 0.0288
Loa Loa (eye worm) latrophilin receptor protein 2 0.006 0.0075 0.0675
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0077 0.0101 0.3006
Entamoeba histolytica hypothetical protein 0.011 0.0153 0.9526
Trichomonas vaginalis apoptosis inducing factor, putative 0.002 0.0013 0.0272
Echinococcus granulosus thioredoxin glutathione reductase 0.0223 0.033 0.0329
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0022 0.017
Echinococcus granulosus lamin dm0 0.0026 0.0022 0.0021
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0005 0.0001
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0048 0.0056 0.1608
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0048 0.0056 0.1608
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0075 0.0206
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0048 0.0056 0.1573
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0413
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0214 0.0211
Schistosoma mansoni hypothetical protein 0.002 0.0013 0.0009
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0072 0.0068
Schistosoma mansoni cellular tumor antigen P53 0.0206 0.0303 0.03
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0049 0.1393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.002 0.002
Echinococcus multilocularis glutamate synthase 0.002 0.0013 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0025
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0013 0.0281
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0024 0.0052
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.0056 0.1608
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0065 0.0177
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.002 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0101 0.2999
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0077 0.0101 0.0906
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0077 0.0101 0.3006
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0075 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0035 0.0932
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.002 0.002
Echinococcus multilocularis lamin dm0 0.0026 0.0022 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.002 0.002
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.002 0.0013 0.0272
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0026 0.0025
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.002 0.002
Brugia malayi jmjC domain containing protein 0.0058 0.0072 0.0618
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.002 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.0349 0.3128
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0077 0.0101 0.2976
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0004 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0101 0.0883
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0005 0.0004
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0077 0.0101 0.3006
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0013 0.0091
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0077 0.0101 0.0101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Schistosoma mansoni intermediate filament proteins 0.0026 0.0022 0.0018
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0064 0.1818
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0077 0.0101 0.0288
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0013 0.0272
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.002 0.0013 0.0241
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.002 0.0157
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0079 0.068
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0035 0.0966
Loa Loa (eye worm) hypothetical protein 0.006 0.0075 0.0675
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0051
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.002 0.0013 0.0018
Schistosoma mansoni ferritin 0.0017 0.0007 0.0003
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0145
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0022 0.0196
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0025 0.0024
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0051
Trichomonas vaginalis ferritin, putative 0.0017 0.0007 0.0095
Onchocerca volvulus 0.0026 0.0022 0.0272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0049 0.0415
Echinococcus multilocularis musashi 0.0026 0.0022 0.0021
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.002 0.0157
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0042
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.016 0.0159
Trichomonas vaginalis esterase, putative 0.0077 0.0101 0.2899
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.016 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.002 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.002 0.0183
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0005
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0042
Loa Loa (eye worm) hypothetical protein 0.0077 0.0101 0.0906
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0077 0.0101 0.0098
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.002 0.0013 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0101 0.2899
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.002 0.002
Giardia lamblia Kinase, CMGC MAPK 0.0048 0.0056 0.5106
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.002 0.0013 0.0273
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0009 0.0077
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0005 0.0004
Echinococcus multilocularis neuropeptide receptor A26 0.0441 0.0673 0.0672
Onchocerca volvulus 0.0026 0.0022 0.0272
Trypanosoma brucei NADH dehydrogenase 0.002 0.0013 0.0281
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0077 0.0101 0.0288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0022
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.1231 0.123
Giardia lamblia Glutamate synthase 0.002 0.0013 0.046
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0005 0.0004
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.002 0.0227
Echinococcus multilocularis mitogen activated protein kinase 0.0048 0.0056 0.0055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0024 0.0625
Schistosoma mansoni hypothetical protein 0.006 0.0075 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0026 0.0022
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.002 0.0013 0.0241
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.002 0.002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0013 0.0012
Schistosoma mansoni glutamate synthase 0.002 0.0013 0.0009
Brugia malayi nuclear receptor NHR-88 0.0025 0.002 0.0157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0101 0.0097
Echinococcus multilocularis ferritin 0.0017 0.0007 0.0006
Schistosoma mansoni patched 1 0.0049 0.0058 0.0054
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0006 0.0005
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0072 0.0071
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.002 0.0013 0.0272
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0506 0.0773 0.234
Brugia malayi RNA binding protein 0.0062 0.0079 0.068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0011 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0153 0.0152
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0013 0.0272
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0013 0.0281
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.002 0.0013 0.0282
Brugia malayi beta-lactamase family protein 0.0077 0.0101 0.0883
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0079 0.0075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.002 0.002
Brugia malayi Pre-SET motif family protein 0.0029 0.0026 0.0209
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0056 0.0069 0.0598
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0101 0.01
Mycobacterium ulcerans beta-lactamase 0.0077 0.0101 0.0287
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0049 0.2668
Echinococcus multilocularis lamin 0.0026 0.0022 0.0021
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0003
Brugia malayi Thioredoxin reductase 0.0222 0.0328 0.2923
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0026 0.0025
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0049 0.0048
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.002 0.0013 0.0018
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0005 0.0001
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.002 0.0013 0.0281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0004 0.0008
Schistosoma mansoni ferritin light chain 0.0017 0.0007 0.0003
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 0.0664
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0072 0.0071
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.002 0.0013 0.0018
Mycobacterium ulcerans lipase LipD 0.0077 0.0101 0.0287
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0064 0.1852
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0072 0.0068
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0004 0.0003
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.0749 0.2265
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 1
Brugia malayi nuclear hormone receptor 0.0025 0.002 0.0157
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.002 0.0013 0.0241
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.002 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0101 0.2899
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.002 0.0013 0.0012
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0101 0.0288
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0049 0.0048
Brugia malayi glutathione reductase 0.0222 0.0328 0.2923
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.002 0.0017
Brugia malayi Pre-SET motif family protein 0.0201 0.0296 0.2633
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0101 0.0097
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0064 0.1852
Loa Loa (eye worm) hypothetical protein 0.0026 0.0022 0.0196
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.002 0.0017
Brugia malayi Smad1 0.0016 0.0006 0.0029
Leishmania major hypothetical protein, conserved 0.0053 0.0064 0.1852
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0009 0.0005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0006 0.0055
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0024 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0079 0.0075
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0005 0.0001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0065 0.2663
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.002 0.0013 0.0281
Mycobacterium tuberculosis Conserved protein 0.0077 0.0101 0.0288
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0058 0.1607
Echinococcus multilocularis protein dispatched 1 0.0056 0.0069 0.0068
Echinococcus multilocularis microtubule associated protein 2 0.6393 1 1
Trypanosoma brucei trypanothione reductase 0.0222 0.0328 1
Onchocerca volvulus 0.0027 0.0024 0.0341
Schistosoma mansoni ferritin 0.0017 0.0007 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.002 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0415
Schistosoma mansoni ap endonuclease 0.0018 0.0009 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 1
Schistosoma mansoni smad 0.0016 0.0006 0.0002
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0006 0.0055
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0075 0.2181
Echinococcus granulosus survival motor neuron protein 1 0.0725 0.1117 0.1116
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0075 0.0206
Onchocerca volvulus 0.0029 0.0026 0.0405
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0077 0.0101 0.3006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0051
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0056 0.1554
Schistosoma mansoni sulfide quinone reductase 0.002 0.0013 0.0009
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0413
Brugia malayi hypothetical protein 0.0053 0.0064 0.0548
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0562 0.0862 0.261
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0153 0.0152
Toxoplasma gondii thioredoxin reductase 0.0222 0.0328 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0056 0.0069 0.0598
Leishmania major hypothetical protein, conserved 0.0015 0.0005 0.0042
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.002 0.0013 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.002 0.0157
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0562 0.0862 0.261
Entamoeba histolytica hypothetical protein 0.011 0.0153 0.9526
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.002 0.0013 0.0241
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Entamoeba histolytica thioredoxin reductase, putative 0.002 0.0013 0.0282
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0048 0.0056 0.1608
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0049 0.0045
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.002 0.0013 0.0273
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.002 0.0013 0.0018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0006 0.0002
Leishmania major hypothetical protein, conserved 0.002 0.0013 0.0281
Plasmodium falciparum ferrodoxin reductase-like protein 0.002 0.0013 0.0241
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.002 0.0013 0.0018
Trypanosoma brucei protein kinase, putative 0.0048 0.0056 0.1608
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.002 0.0013 0.0018
Schistosoma mansoni disulfide oxidoreductase 0.002 0.0013 0.0009
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0075 0.0071
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.002 0.0013 0.0272
Trypanosoma cruzi trypanothione reductase, putative 0.0077 0.0101 0.3006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0021 0.0519
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0013 0.0272
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0024 0.0052
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0005 0.0001
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0024 0.1019
Loa Loa (eye worm) hypothetical protein 0.0049 0.0058 0.0518
Echinococcus multilocularis protein patched 0.0049 0.0058 0.0057
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0032 0.0818
Schistosoma mansoni smad1 5 8 and 0.0016 0.0006 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0026 0.0025
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0077 0.0101 0.2976
Schistosoma mansoni hypothetical protein 0.013 0.0185 0.0181
Echinococcus multilocularis expressed conserved protein 0.0107 0.0149 0.0148
Brugia malayi latrophilin 2 splice variant baaae 0.013 0.0185 0.1634
Schistosoma mansoni sulfide quinone reductase 0.002 0.0013 0.0009
Leishmania major trypanothione reductase 0.0222 0.0328 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0035 0.0966
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.002 0.0227
Brugia malayi MH2 domain containing protein 0.0235 0.0349 0.311
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0119
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0013 0.0248
Brugia malayi TAR-binding protein 0.0062 0.0079 0.068
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0009 0.015
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0216
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0004 0.0035
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0009 0.015
Schistosoma mansoni lamin 0.0026 0.0022 0.0018
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.0189
Echinococcus multilocularis Niemann Pick C1 protein 0.0163 0.0237 0.0236
Leishmania major hypothetical protein, conserved 0.002 0.0013 0.0281
Treponema pallidum thioredoxin reductase (trxB) 0.002 0.0013 0.0273
Entamoeba histolytica glutamate synthase beta subunit, putative 0.002 0.0013 0.0282
Schistosoma mansoni microtubule-associated protein tau 0.6393 1 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0013 0.0281
Echinococcus granulosus lamin 0.0026 0.0022 0.0021
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0006 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.002 0.0183
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0077 0.0101 0.4334
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.0225 0.6794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0415
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0024 0.0625
Loa Loa (eye worm) glutathione reductase 0.0222 0.0328 0.2941
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0009 0.0145
Brugia malayi glutamate synthase 0.002 0.0013 0.0091
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0072 0.0642
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.0141 0.0408
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0058 0.0057
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0506 0.0773 0.234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0415
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.002 0.0013 0.0018
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.006 0.0075 0.0075
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0024 0.0625
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0077 0.0101 0.3006
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0024 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0049 0.1347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0006 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0101 0.0288
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.002 0.0017
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0079 0.0075
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.002 0.0013 0.0241
Schistosoma mansoni hypothetical protein 0.006 0.0075 0.0072
Brugia malayi CHE-14 protein 0.0049 0.0058 0.0493
Brugia malayi beta-lactamase family protein 0.0077 0.0101 0.0883
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0119
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.006 0.0075 0.0075
Echinococcus granulosus tumor protein p63 0.1405 0.2184 0.2183
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.002 0.0013 0.0281
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0064 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0049 0.1347
Echinococcus granulosus neuropeptide receptor A26 0.0441 0.0673 0.0672
Schistosoma mansoni ferritin 0.0017 0.0007 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0009 0.0052
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.002 0.0013 0.0018
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.006 0.0075 0.0651
Trichomonas vaginalis mercuric reductase, putative 0.0077 0.0101 0.2905
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.002 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0024 0.0052
Schistosoma mansoni glutamate synthase 0.002 0.0013 0.0009
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0077 0.0101 0.4175
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.0141 0.0408
Plasmodium falciparum thioredoxin reductase 0.0222 0.0328 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 0.0664
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0101 0.0287
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0051
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0005 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0079 0.0075
Brugia malayi jmjC domain containing protein 0.0058 0.0072 0.0618
Echinococcus multilocularis geminin 0.0167 0.0242 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.002 0.0157
Onchocerca volvulus 0.0148 0.0213 0.6112
Echinococcus multilocularis tumor protein p63 0.1405 0.2184 0.2183
Mycobacterium tuberculosis Probable oxidoreductase 0.0562 0.0862 0.261
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0175 0.0174
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0013 0.0272
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 0.6794
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0101 0.0288
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0006 0.0005
Plasmodium vivax ferrodoxin reductase, putative 0.002 0.0013 0.0241
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0101 0.01
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0013 0.0019
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0056 0.1554
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Echinococcus granulosus GPCR family 2 0.006 0.0075 0.0075
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0048 0.0056 0.1608
Plasmodium vivax glutathione reductase, putative 0.0222 0.0328 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0079 0.0704
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0024 0.0052
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0101 0.0287
Plasmodium falciparum glutathione reductase 0.0222 0.0328 1
Schistosoma mansoni hypothetical protein 0.011 0.0153 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0035 0.0932
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.0225 0.0224
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0026 0.0022
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0064 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0032 0.0827
Loa Loa (eye worm) hypothetical protein 0.0725 0.1117 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0506 0.0773 0.234
Schistosoma mansoni thyroid hormone receptor 0.0149 0.0214 0.0211
Schistosoma mansoni hypothetical protein 0.0047 0.0055 0.0051
Loa Loa (eye worm) hypothetical protein 0.0156 0.0225 0.2013
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0049 0.1393
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0077 0.0101 0.2976
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0024 0.0191
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0101 0.2999
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.0214 0.0214
Plasmodium vivax thioredoxin reductase, putative 0.0222 0.0328 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.002 0.0017
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0077 0.0101 0.2976
Schistosoma mansoni survival motor neuron protein 0.0148 0.0213 0.0209
Mycobacterium ulcerans hypothetical protein 0.0077 0.0101 0.0287
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0056 0.0052
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0072 0.0071
Mycobacterium leprae Probable lipase LipE 0.0077 0.0101 0.0287
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0077 0.0101 0.3006
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0048 0.0056 0.1608
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0077 0.0101 0.0101
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.002 0.0013 0.0091
Onchocerca volvulus 0.0077 0.0101 0.27
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0075 0.0206
Schistosoma mansoni apoferritin-2 0.0017 0.0007 0.0003
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0075 0.2148
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0009 0.0077
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0005 0.0001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0049 0.1393
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0101 0.0288
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0047
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0049 0.1393
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.0141 0.014
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0013 0.0281
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0009 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0064 0.1818
Brugia malayi hypothetical protein 0.011 0.0153 0.1346
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.002 0.0013 0.0018
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0003 0.0026
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0101 0.2899
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0225 0.6794
Onchocerca volvulus 0.0025 0.002 0.0227
Trichomonas vaginalis disulfide oxidoreductase, putative 0.002 0.0013 0.0272
Loa Loa (eye worm) hypothetical protein 0.0027 0.0024 0.0216
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0006 0.0025
Brugia malayi Latrophilin receptor protein 2 0.006 0.0075 0.0651
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0022 0.0531
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0047
Loa Loa (eye worm) hypothetical protein 0.002 0.0013 0.0116
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.002 0.002
Toxoplasma gondii hypothetical protein 0.0054 0.0065 0.185
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.211 0.3289 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.0225 0.6794
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.002 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0013 0.0281
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0013 0.0281
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0006 0.0005
Echinococcus multilocularis survival motor neuron protein 1 0.0725 0.1117 0.1116
Echinococcus granulosus expressed protein 0.0017 0.0007 0.0006
Trichomonas vaginalis glutathione reductase, putative 0.0077 0.0101 0.2905
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.002 0.0013 0.0018
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.002 0.0013 0.0241
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0077 0.0101 0.3006
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0013 0.0281
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.002 0.0157
Brugia malayi Calcitonin receptor-like protein seb-1 0.019 0.0279 0.2481
Loa Loa (eye worm) hypothetical protein 0.0077 0.0101 0.0906
Echinococcus granulosus geminin 0.0167 0.0242 0.0242
Mycobacterium ulcerans NADH dehydrogenase 0.002 0.0013 0.0018
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0049 0.1393
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0077 0.0101 0.0288
Leishmania major hypothetical protein, conserved 0.0077 0.0101 0.2999
Mycobacterium ulcerans hypothetical protein 0.002 0.0013 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0024 0.1019
Trypanosoma cruzi NADH dehydrogenase, putative 0.002 0.0013 0.0281
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0006 0.0051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.002 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0024 0.1019
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0005 0.0004
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0101 0.0288
Mycobacterium ulcerans transcriptional regulator 0.211 0.3289 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.002 0.0013 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0018 0.0413
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.002 0.0157
Mycobacterium ulcerans AcrR family transcriptional regulator 0.211 0.3289 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.006 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0007
Trichomonas vaginalis set domain proteins, putative 0.0229 0.034 1
Brugia malayi steroid hormone receptor 0.0025 0.002 0.0157
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0006 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.002 0.0183
Echinococcus granulosus Smad4 0.0016 0.0006 0.0005
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0024 0.0191
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.0141 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0035 0.0932
Loa Loa (eye worm) pigment dispersing factor receptor c 0.019 0.0279 0.25
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0009 0.0109
Entamoeba histolytica disulphide oxidoreductase, putative 0.002 0.0013 0.0282
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.002 0.002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.019 0.0279 0.2481
Mycobacterium ulcerans monoxygenase 0.002 0.0013 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0025 0.0636
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0024 0.0052
Echinococcus multilocularis mitogen activated protein kinase 3 0.0048 0.0056 0.0055
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.016 0.141
Echinococcus granulosus expressed conserved protein 0.0107 0.0149 0.0148
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0048 0.0056 0.1608
Mycobacterium tuberculosis Probable reductase 0.0506 0.0773 0.234
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.0225 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.002 0.0157
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0506 0.0773 0.234
Giardia lamblia NADH oxidase lateral transfer candidate 0.0077 0.0101 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.002 0.0013 0.0116
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0051
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.002 0.0013 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0027 0.068
Plasmodium vivax SET domain protein, putative 0.0029 0.0026 0.065
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0049 0.2668
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.002 0.0157
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.002 0.0013 0.0281
Trichomonas vaginalis glutamate synthase, putative 0.002 0.0013 0.0272
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0006 0.0005
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.002 0.0013 0.0281
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.002 0.0013 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0079 0.0078
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.002 0.0013 0.0012
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0562 0.0862 0.2605
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0005 0.0047
Echinococcus granulosus neuropeptide s receptor 0.0441 0.0673 0.0672
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0005 0.0042
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.0225 0.0224
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0056 0.1554
Echinococcus granulosus mitogen activated protein kinase 0.0048 0.0056 0.0055
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0009 0.015
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.002 0.0013 0.0012
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0022 0.0196
Schistosoma mansoni glutamate synthase 0.002 0.0013 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0009 0.0109
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0009 0.0008
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0077 0.0101 0.0288
Echinococcus multilocularis neuropeptide s receptor 0.0441 0.0673 0.0672
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.002 0.0013 0.0018
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0065 0.185
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0024 0.0052
Onchocerca volvulus 0.0206 0.0303 0.8891
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0009 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.002 0.0017
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.002 0.0013 0.0241
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0035 0.0932
Loa Loa (eye worm) hypothetical protein 0.0077 0.0101 0.0906
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0013 0.0019
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0101 0.2899
Treponema pallidum oxidoreductase 0.002 0.0013 0.0273
Brugia malayi jmjC domain containing protein 0.0015 0.0005 0.0021
Schistosoma mansoni hypothetical protein 0.006 0.0075 0.0072
Schistosoma mansoni hypothetical protein 0.0148 0.0213 0.0209
Loa Loa (eye worm) hypothetical protein 0.0025 0.002 0.0183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.002 0.0017
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0077 0.0101 0.2976
Mycobacterium ulcerans hypothetical protein 0.0027 0.0024 0.0052
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0079 0.0704

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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