TDR Targets

Basic information

Technical information

TDR Targets ID: 735039
Name: 2-(2-methylphenoxy)-N-[2-(4-methylphenyl)benz otriazol-5-yl]acetamide
MW: 372.42 | Formula: C22H20N4O2
H donors: 1 H acceptors: 3 LogP: 4.93 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccc2c(c1)nn(n2)c1ccc(cc1)C)COc1ccccc1C
InChi: 1S/C22H20N4O2/c1-15-7-10-18(11-8-15)26-24-19-12-9-17(13-20(19)25-26)23-22(27)14-28-21-6-4-3-5-16(21)2/h3-13H,14H2,1-2H3,(H,23,27)
InChiKey: LKAZLKLHUAIYCE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(2-methylphenoxy)-N-[2-(4-methylphenyl)-5-benzotriazolyl]acetamide
2-(2-methylphenoxy)-N-[2-(4-methylphenyl)benzotriazol-5-yl]ethanamide
NCGC00098984-01
CBKinase1_001188
BAS 00892637
N-(2-p-Tolyl-2H-benzotriazol-5-yl)-2-o-tolyloxy-acetamide
CBKinase1_013588
STK183969
Oprea1_485646
EU-0008066
Oprea1_029458
ZINC00843683

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	microtubule-associated protein tau	Starlite/ChEMBL	No references
Bacillus subtilis (strain 168)	ATP-dependent Clp protease proteolytic subunit	Starlite/ChEMBL	No references
Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)	HTH-type transcriptional regulator EthR	Starlite/ChEMBL	References
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K06275 parvin, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma mansoni	microtubule-associated protein tau	Get druggable targets OG5_133504	All targets in OG5_133504
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium ulcerans	TetR family transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Brugia malayi	Probable ClpP-like protease	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	peptidase Clp S14 family	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	Get druggable targets OG5_191427	All targets in OG5_191427
Theileria parva	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Babesia bovis	ATP-dependent Clp protease proteolytic subunit 1, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Schistosoma japonicum	ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	microtubule associated protein 2	Get druggable targets OG5_133504	All targets in OG5_133504
Schistosoma mansoni	peptidase Clp (S14 family)	Get druggable targets OG5_127187	All targets in OG5_127187
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium ulcerans	AcrR family transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma japonicum	ko:K04380 microtubule-associated protein tau, putative	Get druggable targets OG5_133504	All targets in OG5_133504
Mycobacterium ulcerans	transcriptional regulator	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Neospora caninum	ATP-dependent Clp protease proteolytic subunit, related	Get druggable targets OG5_127187	All targets in OG5_127187
Plasmodium yoelii	ATP-dependent Clp protease, proteolytic subunit ClpP, putative	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	Get druggable targets OG5_191427	All targets in OG5_191427
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	Get druggable targets OG5_127187	All targets in OG5_127187
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	Get druggable targets OG5_127187	All targets in OG5_127187
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	Get druggable targets OG5_127187	All targets in OG5_127187

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	Putative V-type proton ATPase subunit F	ATP-dependent Clp protease proteolytic subunit	197 aa	194 aa	54.1 %
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.1 %
Plasmodium berghei	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	180 aa	36.7 %
Plasmodium yoelii	Clp protease	ATP-dependent Clp protease proteolytic subunit	197 aa	183 aa	36.6 %
Chlamydia trachomatis	hypothetical protein	ATP-dependent Clp protease proteolytic subunit	197 aa	171 aa	22.8 %
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	35.5 %
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	ATP-dependent Clp protease proteolytic subunit	197 aa	172 aa	57.0 %
Plasmodium knowlesi	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	189 aa	36.0 %
Schistosoma mansoni	neuropeptide receptor	ATP-dependent Clp protease proteolytic subunit	197 aa	174 aa	20.1 %
Mycobacterium tuberculosis	Probable transcriptional regulator	HTH-type transcriptional regulator EthR	217 aa	184 aa	27.2 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Babesia bovis	ATP-dependent Clp protease proteolytic subunit, putative	ATP-dependent Clp protease proteolytic subunit	197 aa	188 aa	41.5 %
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	ATP-dependent Clp protease proteolytic subunit	197 aa	186 aa	40.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0184	0.5
Entamoeba histolytica	hypothetical protein	0.0107	0.0214	0.6698
Brugia malayi	beta-lactamase	0.0215	0.0474	0.1976
Echinococcus multilocularis	microtubule associated protein 2	0.4177	1	1
Schistosoma mansoni	lamin	0.0027	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0238	0.0528	0.2214
Echinococcus multilocularis	histone deacetylase 6	0.0053	0.0085	0.0081
Toxoplasma gondii	histone deacetylase HDAC1	0.0053	0.0085	0.149
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0474	0.199
Brugia malayi	histone deacetylase 11	0.0053	0.0085	0.0339
Leishmania major	histone deacetylase, putative	0.0053	0.0085	0.149
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.1009	0.2384	1
Schistosoma mansoni	chromobox protein	0.0072	0.013	0.0126
Echinococcus granulosus	GPCR family 2	0.011	0.0221	0.0217
Toxoplasma gondii	histone deacetylase HDAC5	0.0053	0.0085	0.149
Schistosoma mansoni	hypothetical protein	0.011	0.0221	0.0217
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0077	0.0142	0.0138
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0033	0.0035	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0057	0.0237
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.25	0.5968	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0035	0.0041	0.0171
Loa Loa (eye worm)	heterochromatin protein 1	0.0072	0.013	0.0545
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0474	0.199
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0299	0.1253
Trichomonas vaginalis	glucosylceramidase, putative	0.1009	0.2384	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0069	0.0422
Loa Loa (eye worm)	TAR-binding protein	0.0192	0.0418	0.1754
Echinococcus multilocularis	histone deacetylase 6	0.0053	0.0085	0.0081
Loa Loa (eye worm)	transcription factor SMAD2	0.0242	0.0539	0.2263
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.0418	0.0414
Echinococcus granulosus	tumor protein p63	0.1005	0.2372	0.2369
Schistosoma mansoni	hypothetical protein	0.0165	0.0352	0.0348
Entamoeba histolytica	hypothetical protein	0.0107	0.0214	0.6698
Mycobacterium ulcerans	beta-lactamase	0.0215	0.0474	0.0501
Mycobacterium ulcerans	esterase/lipase LipP	0.0215	0.0474	0.0501
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0085	0.0081
Echinococcus multilocularis	musashi	0.0027	0.0021	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0474	0.199
Schistosoma mansoni	hypothetical protein	0.0125	0.0257	0.0253
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0061	0.0369
Schistosoma mansoni	histone deacetylase 1 2 3	0.0053	0.0085	0.0081
Schistosoma mansoni	lamin	0.0027	0.0021	0.0017
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0041	0.0065
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.0336	0.0332
Echinococcus granulosus	histone deacetylase 1	0.0142	0.0299	0.0295
Brugia malayi	TAR-binding protein	0.0192	0.0418	0.174
Brugia malayi	Probable ClpP-like protease	0.0094	0.0184	0.0755
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0069	0.0065
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0041	0.0065
Echinococcus granulosus	histone lysine methyltransferase setb	0.0077	0.0142	0.0138
Plasmodium vivax	histone deacetylase 2, putative	0.0053	0.0085	0.1717
Trypanosoma brucei	hypothetical protein, conserved	0.0215	0.0474	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0077	0.0142	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0474	0.199
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0035	0.0041	0.0037
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0094	0.0184	0.025
Mycobacterium leprae	Probable transcriptional regulatory repressor protein (TetR-family) EthR	0.2505	0.598	1
Toxoplasma gondii	hypothetical protein	0.0033	0.0035	0.04
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0085	0.0081
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0012	0.0008
Echinococcus granulosus	histone deacetylase	0.0053	0.0085	0.0081
Trypanosoma cruzi	histone deacetylase, putative	0.0053	0.0085	0.149
Plasmodium vivax	hypothetical protein, conserved	0.0215	0.0474	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0238	0.0528	0.2201
Onchocerca volvulus		0.0473	0.1094	0.7053
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0085	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0017	0.007
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0085	0.0339
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0004	0.0017
Trypanosoma cruzi	histone deacetylase, putative	0.0053	0.0085	0.149
Loa Loa (eye worm)	hypothetical protein	0.0072	0.013	0.0545
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.017	0.0166
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0215	0.0474	0.199
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0054	0.012
Schistosoma mansoni	hypothetical protein	0.0285	0.0641	0.0637
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0051	0.0213
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Trichomonas vaginalis	glucosylceramidase, putative	0.1009	0.2384	1
Brugia malayi	RNA recognition motif domain containing protein	0.0192	0.0418	0.174
Onchocerca volvulus		0.0215	0.0474	0.3043
Echinococcus multilocularis	histone deacetylase 1	0.0142	0.0299	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0474	0.199
Onchocerca volvulus		0.0147	0.031	0.1981
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.0045	0.0041
Trichomonas vaginalis	D-aminoacylase, putative	0.0215	0.0474	0.1903
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0012	0.0008
Schistosoma mansoni	hypothetical protein	0.0021	0.0007	0.0003
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0094	0.0184	0.3821
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0021	0.0087
Mycobacterium tuberculosis	Probable lipase LipE	0.0215	0.0474	0.0629
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.017	0.0166
Brugia malayi	MH2 domain containing protein	0.0242	0.0539	0.2249
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0021	0.0087
Schistosoma mansoni	cellular tumor antigen P53	0.0147	0.031	0.0306
Schistosoma mansoni	transcription factor LCR-F1	0.0107	0.0214	0.021
Brugia malayi	hypothetical protein	0.0107	0.0214	0.088
Trichomonas vaginalis	histone deacetylase, putative	0.0142	0.0299	0.1159
Mycobacterium tuberculosis	Probable hydrolase	0.0215	0.0474	0.0629
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.017	0.0166
Schistosoma mansoni	alpha-glucosidase	0.0136	0.0283	0.0279
Schistosoma mansoni	microtubule-associated protein tau	0.4177	1	1
Schistosoma mansoni	hypothetical protein	0.0238	0.0528	0.0524
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0184	0.6097
Onchocerca volvulus		0.0047	0.0069	0.0422
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0017	0.0267
Trichomonas vaginalis	histone deacetylase, putative	0.0142	0.0299	0.1159
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0085	0.0356
Echinococcus multilocularis	chromobox protein 1	0.0072	0.013	0.0126
Schistosoma mansoni	bromodomain containing protein	0.0064	0.0112	0.0108
Brugia malayi	PHD-finger family protein	0.0025	0.0018	0.0057
Echinococcus multilocularis	histone deacetylase 3	0.0142	0.0299	0.0295
Loa Loa (eye worm)	histone deacetylase	0.0053	0.0085	0.0356
Trichomonas vaginalis	glucosylceramidase, putative	0.0698	0.1635	0.6825
Trichomonas vaginalis	histone deacetylase, putative	0.0142	0.0299	0.1159
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.0418	0.0414
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0184	0.04	0.0396
Plasmodium falciparum	histone deacetylase, putative	0.0053	0.0085	0.2739
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0055	0.0089	0.0085
Schistosoma mansoni	hypothetical protein	0.0107	0.0214	0.021
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0085	0.0081
Loa Loa (eye worm)	RNA binding protein	0.0192	0.0418	0.1754
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0184	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0062	0.0106	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0069	0.029
Brugia malayi	Histone deacetylase family protein	0.0053	0.0085	0.0339
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0041	0.0065
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.017	0.0166
Echinococcus granulosus	histone deacetylase 3	0.0142	0.0299	0.0295
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0069	0.0065
Loa Loa (eye worm)	histone deacetylase 1	0.0142	0.0299	0.1253
Trypanosoma cruzi	histone deacetylase, putative	0.0053	0.0085	0.149
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Plasmodium vivax	histone deacetylase, putative	0.0053	0.0085	0.1717
Echinococcus multilocularis	histone deacetylase 7	0.0053	0.0085	0.0081
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0077	0.0142	0.0138
Leishmania major	alpha glucosidase II subunit, putative	0.0035	0.0041	0.0529
Mycobacterium tuberculosis	Probable lipase LipD	0.0215	0.0474	0.0629
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.1375	0.3263	0.5387
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0348	0.0792	0.3312
Echinococcus multilocularis	chromobox protein 1	0.0072	0.013	0.0126
Brugia malayi	Latrophilin receptor protein 2	0.011	0.0221	0.0912
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0184	0.04	0.0396
Echinococcus multilocularis	GPCR, family 2	0.011	0.0221	0.0217
Onchocerca volvulus		0.0027	0.0021	0.0108
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0062	0.0106	0.0101
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0125	0.0257	0.0253
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.006	0.01	0.0096
Entamoeba histolytica	hypothetical protein	0.0107	0.0214	0.6698
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0089	0.017	0.0166
Echinococcus granulosus	neuropeptide s receptor	0.0924	0.2179	0.2176
Trichomonas vaginalis	penicillin-binding protein, putative	0.0215	0.0474	0.1903
Echinococcus granulosus	intermediate filament protein	0.0027	0.0021	0.0017
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.011	0.0221	0.0912
Trichomonas vaginalis	penicillin-binding protein, putative	0.0215	0.0474	0.1903
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0069	0.029
Schistosoma mansoni	histone deacetylase	0.0142	0.0299	0.0295
Plasmodium vivax	SET domain protein, putative	0.006	0.01	0.204
Onchocerca volvulus		0.0071	0.0128	0.0804
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0035	0.0041	0.0154
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0089	0.017	0.0166
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0061	0.0103	0.0099
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0215	0.0474	0.0629
Plasmodium vivax	histone deacetylase 1, putative	0.0142	0.0299	0.6268
Mycobacterium ulcerans	hypothetical protein	0.0215	0.0474	0.0501
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0348	0.0792	0.3324
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0248	0.1578
Schistosoma mansoni	zinc finger protein	0.002	0.0005	0.0001
Trypanosoma cruzi	hypothetical protein, conserved	0.0215	0.0474	1
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.1009	0.2384	1
Echinococcus multilocularis	tumor protein p63	0.1005	0.2372	0.2369
Loa Loa (eye worm)	beta-lactamase	0.0215	0.0474	0.199
Leishmania major	hypothetical protein, conserved	0.0215	0.0474	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0184	0.3652
Loa Loa (eye worm)	latrophilin receptor protein 2	0.011	0.0221	0.0927
Onchocerca volvulus		0.0215	0.0474	0.3043
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.0045	0.0041
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0142	0.0299	0.1159
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0017	0.0425
Brugia malayi	intermediate filament protein	0.0027	0.0021	0.007
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0021	0.0017
Brugia malayi	RNA binding protein	0.0192	0.0418	0.174
Echinococcus multilocularis	neuropeptide s receptor	0.0924	0.2179	0.2176
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0416	0.0956	0.401
Schistosoma mansoni	hypothetical protein	0.011	0.0221	0.0217
Schistosoma mansoni	histone deacetylase hda2	0.0053	0.0085	0.0081
Loa Loa (eye worm)	hypothetical protein	0.004	0.0054	0.0226
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0089	0.017	0.0696
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0348	0.0792	0.3312
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0071	0.0128	0.0124
Brugia malayi	Histone deacetylase family protein	0.0053	0.0085	0.0339
Entamoeba histolytica	hypothetical protein	0.0107	0.0214	0.6698
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.011	0.0221	0.0217
Echinococcus granulosus	lysosomal alpha glucosidase	0.0158	0.0336	0.0332
Loa Loa (eye worm)	histone deacetylase 11	0.0053	0.0085	0.0356
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.013	0.0443
Echinococcus multilocularis	geminin	0.0165	0.0352	0.0348
Trichomonas vaginalis	set domain proteins, putative	0.0473	0.1094	0.4531
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.0418	0.0414
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0215	0.0474	0.047
Trypanosoma cruzi	hypothetical protein, conserved	0.0215	0.0474	1
Trichomonas vaginalis	histone deacetylase, putative	0.0142	0.0299	0.1159
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0831	0.1954	0.1951
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0215	0.0474	0.047
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Trichomonas vaginalis	glucosylceramidase, putative	0.1009	0.2384	1
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0035	0.0041	0.0065
Echinococcus granulosus	histone deacetylase 6	0.0053	0.0085	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0147	0.031	0.1301
Echinococcus granulosus	histone deacetylase 6	0.0053	0.0085	0.0081
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0215	0.0474	0.0629
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0041	0.0065
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0215	0.0474	0.0629
Trypanosoma cruzi	histone deacetylase, putative	0.0053	0.0085	0.149
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0215	0.0474	0.0501
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0158	0.0336	0.1409
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0055	0.0089	0.0085
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0061	0.0151
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.011	0.0221	0.0217
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.006	0.01	0.1822
Brugia malayi	histone deacetylase 1 (HD1)	0.0142	0.0299	0.1238
Brugia malayi	beta-lactamase family protein	0.0215	0.0474	0.1976
Trypanosoma brucei	histone deacetylase 3	0.0053	0.0085	0.149
Echinococcus granulosus	chromobox protein 1	0.0072	0.013	0.0126
Echinococcus granulosus	histone deacetylase 6	0.0053	0.0085	0.0081
Trypanosoma brucei	histone deacetylase 4	0.0053	0.0085	0.149
Trichomonas vaginalis	esterase, putative	0.0215	0.0474	0.1903
Loa Loa (eye worm)	hypothetical protein	0.0348	0.0792	0.3324
Mycobacterium tuberculosis	Conserved protein	0.0215	0.0474	0.0629
Echinococcus multilocularis	lamin dm0	0.0027	0.0021	0.0017
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0094	0.0184	0.018
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0061	0.0151
Echinococcus granulosus	zinc finger protein	0.002	0.0005	0.0001
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0158	0.0336	0.1394
Toxoplasma gondii	histone deacetylase HDAC4	0.0053	0.0085	0.149
Brugia malayi	Heterochromatin protein 1	0.0072	0.013	0.0529
Echinococcus multilocularis	lamin	0.0027	0.0021	0.0017
Trichomonas vaginalis	chromobox protein, putative	0.0072	0.013	0.0443
Trypanosoma brucei	histone deacetylase, putative	0.0053	0.0085	0.149
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.011	0.0221	0.0217
Loa Loa (eye worm)	hypothetical protein	0.011	0.0221	0.0927
Schistosoma mansoni	alpha-glucosidase	0.0136	0.0283	0.0279
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.006	0.01	0.0096
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0041	0.0065
Mycobacterium tuberculosis	Probable esterase LipL	0.0215	0.0474	0.0629
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0248	0.104
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0107	0.0214	0.021
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0192	0.0418	0.1754
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0184	0.0771
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.0281	0.0277
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0061	0.0103	0.0099
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0085	0.0081
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0054	0.0322
Trichomonas vaginalis	histone deacetylase, putative	0.0142	0.0299	0.1159
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0069	0.0065
Loa Loa (eye worm)	histone deacetylase 7A	0.0053	0.0085	0.0356
Schistosoma mansoni	hypothetical protein	0.0165	0.0352	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0061	0.0257
Echinococcus multilocularis	histone deacetylase	0.0053	0.0085	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0085	0.0356
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0158	0.0336	0.0332
Schistosoma mansoni	hypothetical protein	0.011	0.0221	0.0217
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0035	0.0041	0.0529
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0041	0.0529
Mycobacterium tuberculosis	Conserved protein	0.0215	0.0474	0.0629
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.2505	0.598	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0107	0.0214	0.021
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0125	0.0257	0.0253
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0135	0.0281	0.0277
Schistosoma mansoni	chromobox protein	0.0072	0.013	0.0126
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Echinococcus granulosus	lamin	0.0027	0.0021	0.0017
Trypanosoma brucei	histone deacetylase 2	0.0053	0.0085	0.149
Trichomonas vaginalis	glucosylceramidase, putative	0.1009	0.2384	1
Entamoeba histolytica	histone deacetylase, putative	0.0142	0.0299	1
Echinococcus granulosus	peptidase Clp S14 family	0.0062	0.0106	0.0101
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0184	1
Brugia malayi	chromobox protein homolog 3	0.004	0.0054	0.0209
Echinococcus granulosus	tar DNA binding protein	0.0192	0.0418	0.0414
Toxoplasma gondii	ABC1 family protein	0.0215	0.0474	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0215	0.0474	0.1903
Trypanosoma cruzi	histone deacetylase 1, putative	0.0142	0.0299	0.6166
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0033	0.0138
Loa Loa (eye worm)	hypothetical protein	0.002	0.0004	0.0017
Echinococcus multilocularis	zinc finger protein	0.002	0.0005	0.0001
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0069	0.0065
Loa Loa (eye worm)	hypothetical protein	0.002	0.0004	0.0017
Brugia malayi	hypothetical protein	0.0121	0.0248	0.1025
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Echinococcus granulosus	lamin dm0	0.0027	0.0021	0.0017
Schistosoma mansoni	histone deacetylase hda2	0.0053	0.0085	0.0081
Leishmania major	histone deacetylase, putative	0.0142	0.0299	0.6166
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0248	0.104
Onchocerca volvulus	Huntingtin homolog	0.0121	0.0248	0.1578
Trypanosoma brucei	glucosidase, putative	0.0035	0.0041	0.0529
Leishmania major	histone deacetylase, putative	0.0142	0.0299	0.6166
Schistosoma mansoni	histone deacetylase	0.0142	0.0299	0.0295
Brugia malayi	mbt repeat family protein	0.0047	0.0069	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0215	0.0474	0.199
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0094	0.0184	0.5
Mycobacterium ulcerans	TetR family transcriptional regulator	0.2505	0.598	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0142	0.0595
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0017	0.0425
Brugia malayi	Bromodomain containing protein	0.0076	0.014	0.0573
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0035	0.0041	0.0065
Trypanosoma cruzi	histone deacetylase, putative	0.0053	0.0085	0.149
Mycobacterium ulcerans	transcriptional regulator	0.2505	0.598	1
Trichomonas vaginalis	glucosylceramidase, putative	0.1009	0.2384	1
Echinococcus granulosus	neutral alpha glucosidase AB	0.0035	0.0041	0.0037
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0041	0.0529
Giardia lamblia	Histone deacetylase	0.0142	0.0299	0.5
Trichomonas vaginalis	histone deacetylase, putative	0.0142	0.0299	0.1159
Plasmodium falciparum	histone deacetylase 1	0.0142	0.0299	1
Plasmodium falciparum	histone deacetylase 2	0.0053	0.0085	0.2739
Echinococcus granulosus	geminin	0.0165	0.0352	0.0348
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0054	0.012
Onchocerca volvulus		0.0027	0.0021	0.0108
Echinococcus granulosus	beta LACTamase domain containing family member	0.0215	0.0474	0.047
Onchocerca volvulus	Glucosylceramidase homolog	0.0662	0.1549	1
Schistosoma mansoni	hypothetical protein	0.011	0.0221	0.0217
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0142	0.0299	0.1159
Trichomonas vaginalis	glucosylceramidase, putative	0.0698	0.1635	0.6825
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0094	0.0184	0.018
Echinococcus multilocularis	tar DNA binding protein	0.0192	0.0418	0.0414
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.0418	0.0414
Echinococcus multilocularis	neuropeptide receptor A26	0.0924	0.2179	0.2176
Schistosoma mansoni	histone deacetylase 4 5	0.0053	0.0085	0.0081
Schistosoma mansoni	peptidase Clp (S14 family)	0.0094	0.0184	0.018
Mycobacterium ulcerans	lipase LipD	0.0215	0.0474	0.0501
Echinococcus granulosus	neuropeptide receptor A26	0.0924	0.2179	0.2176
Schistosoma mansoni	tar DNA-binding protein	0.0192	0.0418	0.0414
Leishmania major	histone deacetylase, putative	0.0053	0.0085	0.149
Mycobacterium leprae	conserved hypothetical protein	0.0215	0.0474	0.0739
Onchocerca volvulus		0.0032	0.0033	0.0186
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0057	0.0095	0.0091
Brugia malayi	hypothetical protein	0.0025	0.0017	0.0053
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0069	0.0065
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0069	0.0065
Schistosoma mansoni	alpha glucosidase	0.0035	0.0041	0.0037
Brugia malayi	Pre-SET motif family protein	0.0416	0.0956	0.4
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0035	0.0041	0.0065
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0007	0.0031
Brugia malayi	mbt repeat family protein	0.0047	0.0069	0.0274
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0033	0.0035	0.1046
Loa Loa (eye worm)	MBCTL1	0.0053	0.0085	0.0356
Trichomonas vaginalis	alpha-glucosidase, putative	0.0035	0.0041	0.0065
Loa Loa (eye worm)	histone deacetylase 3	0.0142	0.0299	0.1253
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.011	0.0221	0.0217
Trypanosoma brucei	histone deacetylase 1	0.0142	0.0299	0.6166
Trichomonas vaginalis	glucosylceramidase, putative	0.1009	0.2384	1
Schistosoma mansoni	lipoxygenase	0.0055	0.0089	0.0085
Onchocerca volvulus		0.0091	0.0176	0.1112
Onchocerca volvulus		0.0215	0.0474	0.3043
Toxoplasma gondii	histone deacetylase HDAC2	0.0142	0.0299	0.6166
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0142	0.0299	0.1159
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0215	0.0474	0.047
Plasmodium vivax	histone deacetylase, putative	0.0053	0.0085	0.1717
Brugia malayi	follicle stimulating hormone receptor	0.0685	0.1604	0.6723
Schistosoma mansoni	histone deacetylase 4 5	0.0053	0.0085	0.0081
Echinococcus granulosus	histone deacetylase 7	0.0053	0.0085	0.0081
Brugia malayi	Pre-SET motif family protein	0.006	0.01	0.0403
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0685	0.1604	0.6729
Mycobacterium tuberculosis	Conserved protein	0.0215	0.0474	0.0629
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0021	0.007
Brugia malayi	beta-lactamase family protein	0.0215	0.0474	0.1976
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0053	0.0085	0.0522
Toxoplasma gondii	histone deacetylase HDAC3	0.0142	0.0299	0.6166
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0215	0.0474	0.1976
Trichomonas vaginalis	glucosylceramidase, putative	0.0662	0.1549	0.6461
Trypanosoma cruzi	histone deacetylase 1, putative	0.0142	0.0299	0.6166
Loa Loa (eye worm)	MH2 domain-containing protein	0.0242	0.0539	0.2263
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0069	0.0065
Echinococcus multilocularis	histone deacetylase 8	0.0053	0.0085	0.0081
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0089	0.017	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0026	0.002	0.0082
Schistosoma mansoni	thyroid hormone receptor	0.0135	0.0281	0.0277
Trichomonas vaginalis	D-aminoacylase, putative	0.0215	0.0474	0.1903
Brugia malayi	Histone deacetylase 1	0.0142	0.0299	0.1238
Echinococcus multilocularis	histone deacetylase 6	0.0053	0.0085	0.0081
Echinococcus granulosus	chromobox protein 1	0.0072	0.013	0.0126
Brugia malayi	histone deacetylase 3 (HD3)	0.0142	0.0299	0.1238
Echinococcus granulosus	histone deacetylase 8	0.0053	0.0085	0.0081
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0094	0.0184	0.3652
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0089	0.017	0.0712
Mycobacterium leprae	Probable lipase LipE	0.0215	0.0474	0.0739
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0021	0.0087
Brugia malayi	Bromodomain containing protein	0.0039	0.0051	0.0195

Activities

Activity type	Activity value	Assay description	Source	Reference
Delta Tm (binding)	= 6.4 degrees C	Binding affinity to Mycobacterium smegmatis mc2 155 EthR assessed as protein thermal unfolding at 20 uM by SYPRO Orange dye based thermal shift assay	ChEMBL.	22738293
EC50 (binding)	> 10 uM	Inhibition of EthR in Mycobacterium tuberculosis H37Rv-GFP infected in mouse Raw 264.7 cells assessed as compound concentration allowing 0.1 uM ethionamide to inhibit 50% microbial growth by automated fluorescent confocal microscopy	ChEMBL.	22738293
GI (binding)	= 10.9 %	Inhibition of EthR in Mycobacterium tuberculosis H37Rv-GFP infected in mouse Raw 264.7 cells assessed as boosting of 0.1 uM ethionamide-induced microbial growth inhibition at 10 uM by automated fluorescent confocal microscopy	ChEMBL.	22738293
IC50 (binding)	= 2.9 uM	Inhibition at EthR in Mycobacterium smegmatis mc2 155 assessed as reactivation of beta-glucuronidase activity measured over 48 hrs by Spectrophotometry	ChEMBL.	22738293
Potency (functional)	= 0.0079 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 0.1259 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 0.8913 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1612418
Search by Saint Jude

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 735039