Detailed information for compound 739705

Basic information

Technical information
  • TDR Targets ID: 739705
  • Name: 5-hydroxy-2,2-dimethyl-7-[2-(3-nitrophenyl)-2 -oxoethoxy]chroman-4-one
  • MW: 371.341 | Formula: C19H17NO7
  • H donors: 1 H acceptors: 5 LogP: 3.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)[N+](=O)[O-])COc1cc(O)c2c(c1)OC(CC2=O)(C)C
  • InChi: 1S/C19H17NO7/c1-19(2)9-15(22)18-14(21)7-13(8-17(18)27-19)26-10-16(23)11-4-3-5-12(6-11)20(24)25/h3-8,21H,9-10H2,1-2H3
  • InChiKey: PUBUJTLPIQKFEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-hydroxy-2,2-dimethyl-7-[2-(3-nitrophenyl)-2-oxo-ethoxy]chroman-4-one
  • 5-hydroxy-2,2-dimethyl-7-[2-(3-nitrophenyl)-2-oxoethoxy]-4-chromanone
  • 5-hydroxy-7-[2-keto-2-(3-nitrophenyl)ethoxy]-2,2-dimethyl-chroman-4-one
  • ZINC01050271
  • CBKinase1_023548
  • CBKinase1_011148

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0251 0.0799
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0473 0.2684 0.377
Loa Loa (eye worm) hypothetical protein 0.0041 0.0113 0.0361
Schistosoma mansoni hypothetical protein 0.0064 0.0251 0.0354
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0073 0.0306 0.1071
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0153 0.0478
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0153 0.0527
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0048 0.0153 0.0527
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0269 0.8592
Echinococcus granulosus fetal alzheimer antigen falz 0.0048 0.0157 0.0192
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.2711 0.95
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0313 0.1082
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.006 0.0226 0.0792
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0022 0.0688
Schistosoma mansoni hypothetical protein 0.0064 0.0251 0.0354
Onchocerca volvulus 0.0176 0.0914 1
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0029 0.004 0.014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0064 0.0061
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0087 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0087 0.0122
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0064 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0078 0.0333 0.1166
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0655 0.2089
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0128 0.0633 0.0865
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0064 0.0091
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0059 0.022 0.0693
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0064 0.0043
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0064 0.0061
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0055 0.0197 0.0619
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0473 0.2684 0.377
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0055 0.0197 0.0689
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0153 0.0516
Schistosoma mansoni hypothetical protein 0.1211 0.7085 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0029 0.004 0.1276
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0029 0.004 0.0138
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0064 0.0061
Leishmania major acetyl-CoA synthetase, putative 0.0048 0.0153 0.0534
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0245 0.1331 0.424
Loa Loa (eye worm) hypothetical protein 0.0075 0.0313 0.0998
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0073 0.0306 0.1071
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0064 0.0205
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0055 0.0197 0.0689
Echinococcus granulosus voltage dependent calcium channel 0.0165 0.0849 0.1172
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0313 0.1098
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0153 0.0534
Onchocerca volvulus 0.0075 0.0313 0.2931
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0486
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0116 0.0561 0.1788
Mycobacterium ulcerans polyketide synthase 0.0078 0.0333 0.1053
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0251 0.023
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0165 0.0849 1
Schistosoma mansoni hypothetical protein 0.0139 0.0695 0.0981
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0087 0.0122
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0048 0.0153 0.0478
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0048 0.0157 0.0136
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0313 0.0413
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0023 0.0003 0.001
Echinococcus multilocularis GPCR, family 2 0.0064 0.0251 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0064 0.0205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0313 0.1098
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0269 0.038
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0153 0.1583
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0153 0.4664
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0048 0.0153 0.0185
Onchocerca volvulus 0.0116 0.0561 0.5849
Echinococcus multilocularis voltage dependent calcium channel 0.0473 0.2684 0.2669
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Loa Loa (eye worm) hypothetical protein 0.0075 0.0313 0.0998
Loa Loa (eye worm) hypothetical protein 0.0064 0.0251 0.0799
Loa Loa (eye worm) hypothetical protein 0.0088 0.039 0.1242
Mycobacterium ulcerans beta-lactamase 0.0075 0.0313 0.099
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0486
Schistosoma mansoni zinc finger protein 0.0033 0.0064 0.009
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.011 0.0522 0.1829
Brugia malayi Bromodomain containing protein 0.0161 0.0828 0.264
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0313 0.108
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0486
Mycobacterium ulcerans lipase LipD 0.0075 0.0313 0.099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0245 0.1331 0.1312
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0473 0.2684 0.2669
Echinococcus granulosus GPCR family 2 0.0064 0.0251 0.0325
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0153 0.0534
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0073 0.0306 0.1071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0245 0.1331 0.1853
Entamoeba histolytica hypothetical protein 0.0073 0.0302 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0048 0.0153 0.0478
Mycobacterium tuberculosis Conserved protein 0.0075 0.0313 0.1098
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0508 0.2893 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.011 0.0522 0.1829
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0055 0.0197 0.0627
Entamoeba histolytica acyl-CoA synthetase, putative 0.0055 0.0197 0.6237
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0313 0.1098
Schistosoma mansoni bromodomain containing protein 0.0136 0.0678 0.0958
Loa Loa (eye worm) hypothetical protein 0.0145 0.0731 0.2329
Schistosoma mansoni hypothetical protein 0.0044 0.0132 0.0187
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0053 0.0182 0.0639
Leishmania major hypothetical protein, conserved 0.0075 0.0313 0.1098
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0029 0.004 0.0223
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0064 0.0043
Schistosoma mansoni hypothetical protein 0.0037 0.0086 0.0121
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0048 0.0153 0.0131
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0486
Trichomonas vaginalis antibiotic synthetase, putative 0.0048 0.0153 0.487
Entamoeba histolytica Flap nuclease, putative 0.0029 0.004 0.0656
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0153 0.0534
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0078 0.0333 0.1149
Echinococcus multilocularis muscleblind protein 1 0.0155 0.079 0.077
Mycobacterium leprae Polyketide synthase Pks13 0.011 0.0522 0.1813
Trichomonas vaginalis antibiotic synthetase, putative 0.0048 0.0153 0.487
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0023 0.0006 0.002
Brugia malayi Bromodomain containing protein 0.0082 0.0359 0.1143
Onchocerca volvulus Huntingtin homolog 0.0121 0.0587 0.6149
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0153 0.0516
Mycobacterium ulcerans polyketide synthase 0.0073 0.0306 0.0966
Brugia malayi hypothetical protein 0.0053 0.0181 0.0577
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0353 1
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0353 0.4005
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0695 0.2214
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0055 0.0197 0.0619
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0044 0.0129 0.1296
Trichomonas vaginalis esterase, putative 0.0075 0.0313 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0064 0.0043
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0486
Schistosoma mansoni FFA transport protein 0.0508 0.2893 0.4084
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0087 0.0122
Trypanosoma cruzi ISWI complex protein 0.0033 0.0064 0.0221
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0049 0.0157 0.0494
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0473 0.2684 0.2669
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0064 0.0205
Brugia malayi hypothetical protein 0.0121 0.0587 0.1869
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0064 0.0091
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0086 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.013 0.0642 0.2047
Brugia malayi MH2 domain containing protein 0.0132 0.0655 0.2089
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0064 0.0205
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0486
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0087 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0064 0.0205
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0153 0.0534
Onchocerca volvulus 0.0048 0.0153 0.1039
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0087 0.0065
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0469 0.0663
Mycobacterium ulcerans thioesterase 0.0061 0.0233 0.0733
Loa Loa (eye worm) hypothetical protein 0.0152 0.0774 0.2465
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0153 0.0534
Loa Loa (eye worm) oxidoreductase 0.0048 0.0153 0.0486
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0473 0.2684 0.3789
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0153 0.4664
Echinococcus granulosus geminin 0.1211 0.7085 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0061 0.0233 0.0797
Mycobacterium tuberculosis Conserved protein 0.0075 0.0313 0.1098
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.0306 0.0966
Mycobacterium ulcerans polyketide synthase Pks9 0.0049 0.0157 0.0494
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0333 0.1053
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0132 0.0422
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0025 0.0019 0.0065
Toxoplasma gondii ABC1 family protein 0.0075 0.0313 0.3524
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0042 0.0135
Loa Loa (eye worm) hypothetical protein 0.0092 0.0414 0.132
Loa Loa (eye worm) voltage-dependent calcium channel 0.0165 0.0849 0.2706
Loa Loa (eye worm) beta-lactamase 0.0075 0.0313 0.0998
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0064 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0549 0.3138 1
Brugia malayi nuclear hormone receptor 0.0033 0.0064 0.0205
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0251 0.023
Loa Loa (eye worm) hypothetical protein 0.0165 0.0849 0.2706
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.0501 0.2854 1
Schistosoma mansoni hypothetical protein 0.0033 0.0064 0.009
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0048 0.0157 0.0221
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0469 0.0663
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0251 0.0325
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0469 0.5411
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0473 0.2684 0.8554
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0064 0.0091
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0055 0.0197 0.0689
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0353 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0064 0.0205
Schistosoma mansoni voltage-gated cation channel 0.0473 0.2684 0.3789
Mycobacterium ulcerans polyketide synthase Pks13 0.011 0.0522 0.1656
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0153 0.0478
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0153 0.0534
Mycobacterium leprae Probable lipase LipE 0.0075 0.0313 0.108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0245 0.1331 0.1312
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0153 0.0478
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0041 0.0113 0.0396
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0139 0.0697 0.2222
Leishmania major hypothetical protein, conserved 0.0033 0.0064 0.0225
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0073 0.0306 0.1053
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0059 0.022 0.0753
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0655 0.2089
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0313 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0086 0.0091
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0064 0.0061
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0048 0.0153 0.0534
Plasmodium vivax acetyl-CoA synthetase, putative 0.0048 0.0153 0.3596
Loa Loa (eye worm) hypothetical protein 0.0075 0.0313 0.0998
Mycobacterium ulcerans acetyl-CoA synthetase 0.0048 0.0153 0.0478
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.0306 0.0966
Brugia malayi hypothetical protein 0.0073 0.0302 0.0964
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0064 0.0091
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0469 0.0663
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0064 0.0205
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0251 0.0799
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0064 0.0091
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0042 0.0117 0.041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.1077 0.3433
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0353 0.122
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0064 0.0061
Onchocerca volvulus 0.0055 0.0197 0.1559
Loa Loa (eye worm) hypothetical protein 0.0121 0.0587 0.1869
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0313 0.1098
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0064 0.0043
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0064 0.0091
Echinococcus multilocularis flap endonuclease 1 0.0029 0.004 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0469 0.0634
Schistosoma mansoni hypothetical protein 0.0073 0.0302 0.0427
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0313 0.099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0064 0.0043
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0153 0.0527
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0549 0.3138 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0359 0.1145
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0153 0.0534
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0486
Leishmania major fatty acid transporter protein-like protein 0.0501 0.2854 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0064 0.0205
Brugia malayi nuclear receptor NHR-88 0.0033 0.0064 0.0205
Echinococcus multilocularis muscleblind protein 0.0155 0.079 0.077
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0313 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0087 0.0276
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0064 0.0061
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0048 0.0153 0.0527
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0128 0.0633 0.0612
Mycobacterium ulcerans thioesterase TesA 0.0061 0.0233 0.0733
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0501 0.2854 1
Loa Loa (eye worm) calcium channel 0.0473 0.2684 0.8554
Brugia malayi hypothetical protein 0.0081 0.0353 0.1125
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0313 0.1098
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0073 0.0306 0.1053
Trypanosoma brucei ISWI complex protein 0.0033 0.0064 0.0514
Onchocerca volvulus Fatty acid synthase homolog 0.0132 0.0657 0.6973
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0064 0.0091
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0473 0.2684 0.2669
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0064 0.0205
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0064 0.0091
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0153 0.0478
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0473 0.2684 0.2669
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0313 1
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0251 0.0799
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0064 0.0043
Loa Loa (eye worm) hypothetical protein 0.0473 0.2684 0.8554
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0048 0.0153 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0064 0.0205
Echinococcus multilocularis voltage dependent calcium channel 0.0473 0.2684 0.2669
Schistosoma mansoni zinc finger protein 0.0042 0.0119 0.0168
Toxoplasma gondii type I fatty acid synthase, putative 0.0085 0.0372 0.4238
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0064 0.0043
Schistosoma mansoni hypothetical protein 0.0064 0.0251 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0087 0.0122
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0064 0.0043
Onchocerca volvulus Huntingtin homolog 0.0121 0.0587 0.6149
Brugia malayi beta-lactamase family protein 0.0075 0.0313 0.0998
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0078 0.0333 0.1053
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0048 0.0153 0.1583
Onchocerca volvulus 0.0048 0.0153 0.1039
Brugia malayi ecdysteroid receptor 0.0033 0.0064 0.0205
Echinococcus multilocularis zinc finger protein 0.0042 0.0119 0.0098
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0029 0.004 0.0223
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0486
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0302 0.0398
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0469 0.0663
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0116 0.0561 0.1966
Mycobacterium ulcerans hypothetical protein 0.0048 0.0153 0.0478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0064 0.0205
Onchocerca volvulus 0.0075 0.0313 0.2931
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0064 0.0205
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0078 0.0333 0.1149
Loa Loa (eye worm) hypothetical protein 0.0203 0.1077 0.3433
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0064 0.0205
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0078 0.0333 0.1166
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0245 0.1331 0.424
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0073 0.0306 0.0966
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0048 0.0153 0.0516
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0087 0.0065
Echinococcus granulosus flap endonuclease 1 0.0029 0.004 0.0026
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0022 0.0069
Loa Loa (eye worm) hypothetical protein 0.0145 0.0731 0.2329
Loa Loa (eye worm) hypothetical protein 0.0075 0.0313 0.0998
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.1331 0.1878
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0353 0.4005
Mycobacterium ulcerans acyl-CoA synthetase 0.0055 0.0197 0.0619
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0165 0.0849 0.2935
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0064 0.0205
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0055 0.0197 0.0619
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0313 0.3524
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0302 0.0427
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0313 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0313 0.0998
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0048 0.0153 0.0534
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0064 0.0205
Echinococcus granulosus zinc finger protein 0.0042 0.0119 0.0138
Schistosoma mansoni flap endonuclease-1 0.0026 0.0023 0.0033
Brugia malayi Melibiase family protein 0.0067 0.0269 0.0858
Loa Loa (eye worm) hypothetical protein 0.0139 0.0695 0.2214
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0353 0.122
Echinococcus multilocularis geminin 0.1211 0.7085 0.7078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.1331 0.1878
Loa Loa (eye worm) hypothetical protein 0.0121 0.0587 0.1869
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Toxoplasma gondii transporter, cation channel family protein 0.0165 0.0849 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0022 0.0074
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0064 0.0205
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0055 0.0197 0.0619
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0077 0.0328 0.0434
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0313 0.8728
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0469 0.0449
Loa Loa (eye worm) hypothetical protein 0.0081 0.0353 0.1125
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0549 0.3138 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0469 0.0449
Brugia malayi AMP-binding enzyme family protein 0.0116 0.0561 0.1788
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0094 0.0301
Leishmania major hypothetical protein, conserved 0.0081 0.0353 0.1237
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0064 0.0205
Echinococcus granulosus muscleblind protein 0.0155 0.079 0.1088
Loa Loa (eye worm) fatty acid synthase 0.0072 0.03 0.0955
Mycobacterium tuberculosis Conserved protein 0.0075 0.0313 0.1098
Brugia malayi Muscleblind-like protein 0.0155 0.079 0.2518
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0071 0.0292 0.1024
Loa Loa (eye worm) hypothetical protein 0.0075 0.0313 0.0998
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0313 1
Onchocerca volvulus 0.0075 0.0313 0.2931
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0077 0.0328 0.0307
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0064 0.0205
Loa Loa (eye worm) flap endonuclease-1 0.0029 0.004 0.0127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0153 0.0534
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0203 0.1077 0.3433
Echinococcus granulosus voltage dependent calcium channel 0.0473 0.2684 0.377
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0353 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.1077 0.3433
Mycobacterium leprae Probable polyketide synthase Pks1 0.0078 0.0333 0.1149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0064 0.0205
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0071 0.0292 0.1024
Brugia malayi steroid hormone receptor 0.0033 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0064 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0064 0.0205
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0048 0.0152 0.1576
Echinococcus granulosus long chain fatty acid transport protein 4 0.0508 0.2893 0.4066
Brugia malayi beta-lactamase 0.0075 0.0313 0.0998
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0313 0.0442
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0313 0.1082
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0059 0.022 0.0693
Brugia malayi beta-lactamase family protein 0.0075 0.0313 0.0998
Toxoplasma gondii hypothetical protein 0.0145 0.0731 0.857
Mycobacterium ulcerans hypothetical protein 0.0075 0.0313 0.099
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0313 0.1098
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0064 0.0091
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0048 0.0153 0.3596
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0313 0.0998
Schistosoma mansoni hypothetical protein 0.1211 0.7085 1
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0048 0.0153 0.1583
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0473 0.2684 0.377
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0153 0.0516
Entamoeba histolytica hypothetical protein 0.0073 0.0302 1
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0508 0.2893 0.2878
Brugia malayi Flap endonuclease-1 0.0029 0.004 0.0127
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0313 0.0442
Mycobacterium ulcerans Type I modular polyketide synthase 0.0073 0.0306 0.0966
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.003 0.0045 0.0158
Leishmania major acetyl-CoA synthetase, putative 0.0048 0.0153 0.0534
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0049 0.0157 0.0533
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0508 0.2893 1
Mycobacterium tuberculosis Probable thioesterase TesA 0.0061 0.0233 0.0815
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0245 0.1331 0.1853
Entamoeba histolytica hypothetical protein 0.0073 0.0302 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0052 0.018 0.1909
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0064 0.0205
Loa Loa (eye worm) hypothetical protein 0.0048 0.0153 0.0486
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0055 0.0197 0.0689
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0064 0.0091
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0064 0.0061
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0313 0.099
Giardia lamblia Flap structure-specific endonuclease 0.0029 0.004 1
Loa Loa (eye worm) acyl carrier protein 0.0034 0.0069 0.0221
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0048 0.0153 0.4664
Brugia malayi PHD-finger family protein 0.0054 0.0187 0.0596
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0302 0.0281
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0022 0.003
Toxoplasma gondii propionate-CoA ligase 0.0048 0.0153 0.1583
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0078 0.0333 0.1166
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0064 0.0205
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0048 0.0153 0.1583
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0048 0.0153 0.0486
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0473 0.2684 0.3789
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0153 0.0478
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0153 0.0478
Schistosoma mansoni hypothetical protein 0.0064 0.0251 0.0354
Loa Loa (eye worm) hypothetical protein 0.0075 0.0313 0.0998
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0251 0.0325
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0073 0.0306 0.0974
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0064 0.0043
Loa Loa (eye worm) hypothetical protein 0.0067 0.0269 0.0857
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0269 0.038
Loa Loa (eye worm) hypothetical protein 0.0155 0.079 0.2518
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0313 0.0292
Loa Loa (eye worm) hypothetical protein 0.0033 0.0064 0.0205
Entamoeba histolytica hypothetical protein 0.0073 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.079 0.2518
Trypanosoma cruzi ISWI complex protein 0.0033 0.0064 0.0221
Schistosoma mansoni coup transcription factor 0.0033 0.0064 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0153 0.0486
Schistosoma mansoni acetyl-CoA synthetase 0.0048 0.0153 0.0215
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0055 0.0197 0.0671
Mycobacterium ulcerans fatty acid synthase Fas 0.0023 0.0006 0.0009
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0153 0.0534
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0313 0.1098
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0245 0.1331 0.1878

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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