Detailed information for compound 74606

Basic information

Technical information
  • TDR Targets ID: 74606
  • Name: 2,5-dinitrophenanthrene-9,10-dione
  • MW: 298.207 | Formula: C14H6N2O6
  • H donors: 0 H acceptors: 6 LogP: 2.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=O)c2cccc(c2c2c1cc(cc2)[N+](=O)[O-])[N+](=O)[O-]
  • InChi: 1S/C14H6N2O6/c17-13-9-2-1-3-11(16(21)22)12(9)8-5-4-7(15(19)20)6-10(8)14(13)18/h1-6H
  • InChiKey: JWHYMQNUBIWXBR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,5-dinitrophenanthrene-9,10-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0009 0.0031
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0104 0.0275 0.0634
Toxoplasma gondii PAN domain-containing protein 0.0016 0 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0073 0.0065
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0079 0.0296
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0073 0.0065
Echinococcus multilocularis musashi 0.0115 0.0309 0.03
Onchocerca volvulus 0.006 0.0138 0.045
Schistosoma mansoni hypothetical protein 0.0287 0.0841 0.1941
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0014 0.0071
Onchocerca volvulus 0.0027 0.0035 0.0113
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0157 0.4722
Entamoeba histolytica hypothetical protein 0.0042 0.0081 0.267
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.007 0.0062
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.007
Loa Loa (eye worm) CUTiclin family member 0.006 0.0138 0.0513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0073 0.0273
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0079 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0073 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0073 0.0273
Brugia malayi hypothetical protein 0.0019 0.0009 0.0031
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0009 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0303 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0073 0.0065
Brugia malayi hypothetical protein 0.0019 0.0009 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0135 0.3921
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0296
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.006 0.0138 0.3653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Schistosoma mansoni polycystin 1-related 0.0022 0.0019 0.0044
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0079 0.0233
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.005 0.0187
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Onchocerca volvulus 0.006 0.0138 0.045
Schistosoma mansoni aldehyde dehydrogenase 0.0269 0.0788 0.1818
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0073 0.0065
Schistosoma mansoni lipoxygenase 0.0022 0.0019 0.0044
Brugia malayi hypothetical protein 0.0041 0.0079 0.0296
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0019 0.0011
Schistosoma mansoni coup transcription factor 0.0039 0.0073 0.0169
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0303 0.0434
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.0375
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0079 0.0183
Loa Loa (eye worm) hypothetical protein 0.0025 0.0027 0.0101
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Entamoeba histolytica hypothetical protein 0.006 0.0138 0.4546
Echinococcus granulosus pikachurin 0.0048 0.0101 0.0092
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0073 0.0065
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0056 0.0124 0.0115
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0071 0.2333
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0079 0.0183
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0019 0.0011
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0071 0.0062
Brugia malayi ecdysteroid receptor 0.0039 0.0073 0.0273
Onchocerca volvulus 0.0032 0.005 0.0164
Schistosoma mansoni hypothetical protein 0.006 0.0138 0.0317
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.0233
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0135 0.5
Toxoplasma gondii microneme protein MIC2 0.006 0.0138 0.1746
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0071 0.4896
Treponema pallidum 76K protein 0.006 0.0138 0.0155
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0064 0.1325
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0123
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0296
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0073 0.0273
Brugia malayi Receptor family ligand binding region containing protein 0.0024 0.0024 0.0088
Toxoplasma gondii hypothetical protein 0.0016 0 0.0006
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0046 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.0233
Echinococcus multilocularis lamin 0.0115 0.0309 0.03
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0079 0.0071
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0296
Toxoplasma gondii exonuclease III APE 0.0059 0.0135 0.1718
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0036 0.0064 0.0845
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0079 0.0071
Echinococcus granulosus geminin 0.0189 0.0538 0.053
Loa Loa (eye worm) hypothetical protein 0.0056 0.0124 0.0461
Brugia malayi Kringle domain containing protein 0.0025 0.0027 0.0101
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Echinococcus multilocularis slit 2 protein 0.0048 0.0101 0.0092
Brugia malayi CXXC zinc finger family protein 0.0032 0.005 0.0187
Echinococcus multilocularis geminin 0.0189 0.0538 0.053
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0303 0.3618
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0126 0.0343 0.1283
Toxoplasma gondii microneme protein MIC17B 0.0016 0 0.0006
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0024 0.0024 0.0088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0269 0.0788 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0302 0.1129
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0135 0.0418
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0303 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0092 0.0236 0.0881
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.0375
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0073 0.0065
Echinococcus granulosus histone lysine methyltransferase setb 0.0126 0.0343 0.0335
Schistosoma mansoni nuclear receptor 0.0019 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0101 0.0232
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0071 0.0204
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.007
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0157 0.443
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0157 0.0588
Echinococcus multilocularis pikachurin 0.0048 0.0101 0.0092
Loa Loa (eye worm) carboxylesterase 0.016 0.0448 0.1677
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0079 0.0071
Schistosoma mansoni rotamase 0.0037 0.0067 0.0154
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0246 0.0716 0.268
Brugia malayi Cytochrome P450 family protein 0.0072 0.0176 0.0657
Echinococcus multilocularis BC026374 protein (S09 family) 0.0027 0.0035 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0009 0.002
Toxoplasma gondii peptidylprolyl isomerase 0.0036 0.0064 0.0812
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Echinococcus multilocularis thyroid hormone receptor alpha 0.0326 0.0964 0.0956
Onchocerca volvulus 0.0057 0.0129 0.0423
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0101 0.0092
Toxoplasma gondii endonuclease IV APN 0.0077 0.0191 0.242
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0071 0.0163
Echinococcus granulosus tissue type plasminogen activator 0.0025 0.0027 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0067 0.0192
Brugia malayi Carboxylesterase family protein 0.016 0.0448 0.1677
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0343 0.0792
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Schistosoma mansoni lipoxygenase 0.0062 0.0142 0.0328
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0123
Loa Loa (eye worm) hypothetical protein 0.0053 0.0117 0.0436
Brugia malayi ecdysone receptor 0.0019 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0073 0.0273
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.0154 0.1952
Onchocerca volvulus 0.006 0.0138 0.045
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0101 0.0375
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0041 0.0079 0.0296
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0016 0.0057
Onchocerca volvulus 0.0027 0.0035 0.0113
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0041 0.0079 0.0296
Schistosoma mansoni aldehyde dehydrogenase 0.0269 0.0788 0.1818
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0079 0.0183
Echinococcus granulosus dnaJ subfamily B 0.0456 0.1368 0.1361
Onchocerca volvulus 0.0022 0.0019 0.0062
Loa Loa (eye worm) hypothetical protein 0.0053 0.0117 0.0436
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0009 0.0031
Loa Loa (eye worm) glutamate receptor 0.0036 0.0063 0.0234
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0077 0.019 0.0181
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0016 0.0007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Schistosoma mansoni hypothetical protein 0.0025 0.0027 0.0063
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Onchocerca volvulus 0.0025 0.0027 0.0089
Echinococcus multilocularis bloom syndrome protein 0.0044 0.0086 0.0078
Brugia malayi tailless protein 0.0019 0.0009 0.0031
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0157 0.0149
Echinococcus granulosus expressed protein 0.0037 0.0067 0.0058
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Brugia malayi Pre-SET motif family protein 0.0875 0.2672 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0079 0.0296
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0077 0.0191 0.6121
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0079 0.0296
Onchocerca volvulus 0.0039 0.0073 0.0239
Brugia malayi Carboxylesterase family protein 0.0027 0.0035 0.0129
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0071 0.1567
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0042 0.0524
Onchocerca volvulus 0.0022 0.0019 0.0062
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0073 0.0273
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0079 0.0071
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0079 0.0071
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0135 0.3921
Echinococcus granulosus cpg binding protein 0.0034 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Schistosoma mansoni lamin 0.0115 0.0309 0.0712
Echinococcus multilocularis cpg binding protein 0.0034 0.0056 0.0047
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0079 0.0183
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0036 0.0064 0.1325
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0073 0.0065
Schistosoma mansoni cpg binding protein 0.0034 0.0056 0.0129
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0157 0.0588
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0123
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0042 0.1322
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0016 0.0057
Loa Loa (eye worm) acetylcholinesterase 1 0.016 0.0448 0.1677
Echinococcus granulosus expressed protein 0.0805 0.2452 0.2445
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0073 0.0065
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0079 0.0183
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0101 0.0092
Brugia malayi hypothetical protein 0.0246 0.0716 0.2679
Trichomonas vaginalis DNA helicase recq, putative 0.0044 0.0086 0.0256
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0788 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0135 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.0233
Brugia malayi Bloom's syndrome protein homolog 0.0044 0.0086 0.0322
Mycobacterium ulcerans epimerase 0.002 0.0014 0.0071
Toxoplasma gondii aldehyde dehydrogenase 0.0269 0.0788 1
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Echinococcus multilocularis voltage dependent calcium channel subunit 0.147 0.4521 0.4517
Loa Loa (eye worm) hypothetical protein 0.016 0.0448 0.1677
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0115 0.0309 0.1153
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0071 0.0062
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0027 0.0035 0.0026
Entamoeba histolytica recQ family helicase, putative 0.0034 0.0055 0.1826
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0123
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0027 0.0035 0.0026
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0046 0.1558
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0026 0.0031 0.0365
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0079 0.0183
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.006 0.0138 0.3653
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0079 0.0071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0073 0.0169
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0016 0.0036
Echinococcus granulosus lamin dm0 0.0115 0.0309 0.03
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0191 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0071 0.0062
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Echinococcus multilocularis collagen alpha 1(VII) chain 0.006 0.0138 0.0129
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.016 0.0448 0.1034
Toxoplasma gondii PAN domain-containing protein 0.0016 0 0.0006
Toxoplasma gondii microneme protein MIC4 0.0016 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0024 0.0024 0.0088
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0046 0.0583
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0303 1
Brugia malayi nuclear receptor RXR 0.0021 0.0016 0.0057
Brugia malayi nuclear receptor NHR-88 0.0039 0.0073 0.0273
Brugia malayi Immunoglobulin I-set domain containing protein 0.006 0.0138 0.0513
Schistosoma mansoni hypothetical protein 0.0189 0.0538 0.1241
Loa Loa (eye worm) hypothetical protein 0.016 0.0448 0.1677
Toxoplasma gondii PAN/Apple domain-containing protein 0.0016 0 0.0006
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0046 0.0825
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0296
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0009 0.0027
Echinococcus granulosus metabotropic glutamate receptor 2 0.0077 0.019 0.0181
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0303 0.1131
Onchocerca volvulus 0.0996 0.3048 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0009 0.002
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0041 0.0078 0.3441
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0027 0.0035 0.034
Entamoeba histolytica hypothetical protein 0.0041 0.0079 0.2623
Brugia malayi Carboxylesterase family protein 0.0027 0.0035 0.0129
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0135 0.0127
Onchocerca volvulus 0.0027 0.0035 0.0113
Echinococcus granulosus intermediate filament protein 0.0115 0.0309 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0073 0.0065
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Entamoeba histolytica hypothetical protein 0.0042 0.0081 0.267
Brugia malayi hypothetical protein 0.006 0.0138 0.0513
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0014 0.0051
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0081 0.0072
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0031 0.0047 0.0039
Plasmodium vivax SET domain protein, putative 0.0126 0.0343 1
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Treponema pallidum hypothetical protein 0.006 0.0138 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0051
Toxoplasma gondii subtilisin SUB12 0.0016 0 0.0006
Toxoplasma gondii PAN domain-containing protein 0.0016 0 0.0006
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0019 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.0233
Brugia malayi hypothetical protein 0.0019 0.0008 0.003
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.006 0.0138 0.6901
Echinococcus granulosus collagen alpha 1VII chain 0.006 0.0138 0.0129
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0073 0.0065
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.1368 0.1361
Giardia lamblia Sgs1 DNA helicase, putative 0.0031 0.0047 0.305
Trichomonas vaginalis rotamase, putative 0.0036 0.0064 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0073 0.0273
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0073 0.0169
Brugia malayi conserved hypotetical protein 0.0019 0.0009 0.0031
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0046 0.0825
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0071 0.0062
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.006 0.0138 0.1746
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0303 0.1131
Mycobacterium tuberculosis Carboxylesterase LipT 0.0027 0.0035 0.034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Brugia malayi nuclear receptor NHR-88 0.0019 0.0009 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0073 0.0065
Toxoplasma gondii microneme protein, putative 0.0016 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.0057 0.0129 0.0483
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.0055 0.101
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0343 0.0792
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0176 0.0407
Schistosoma mansoni cpg binding protein 0.0032 0.005 0.0116
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0073 0.0169
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Schistosoma mansoni hypothetical protein 0.0456 0.1368 0.3156
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0071 0.0204
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.006 0.0138 0.0425
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Toxoplasma gondii microneme protein MIC17C 0.0016 0 0.0006
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0079 0.0296
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0129 0.0299
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0135 0.0418
Brugia malayi Intermediate filament tail domain containing protein 0.0115 0.0309 0.1153
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0027 0.0035 0.0081
Schistosoma mansoni rab6-interacting 0.0022 0.0019 0.0044
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0073 0.0169
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0031 0.0047 0.1628
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0135 0.1628
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0046 0.1558
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.0055 0.0365
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0071 0.0062
Brugia malayi Sulfatase family protein 0.0019 0.0008 0.003
Echinococcus granulosus slit 2 protein 0.0048 0.0101 0.0092
Echinococcus granulosus leukotriene A 4 hydrolase 0.0258 0.0753 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0079 0.0183
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0027 0.0035 0.034
Brugia malayi hypothetical protein 0.0019 0.001 0.0035
Schistosoma mansoni intermediate filament proteins 0.0115 0.0309 0.0712
Schistosoma mansoni DNA helicase recq1 0.0031 0.0047 0.0109
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0079 0.0071
Chlamydia trachomatis endonuclease IV 0.0077 0.0191 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0123
Brugia malayi PXA domain containing protein 0.0041 0.0079 0.0296
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0016 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0042 0.07
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0081 0.0072
Echinococcus granulosus metabotropic glutamate receptor 5 0.0113 0.0302 0.0293
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0009 0.0027
Entamoeba histolytica elongation factor-2 kinase, putative 0.006 0.0138 0.4546
Onchocerca volvulus 0.0019 0.0009 0.0027
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0079 0.0296
Brugia malayi 6-phosphofructokinase 0.0113 0.0303 0.1131
Brugia malayi hypothetical protein 0.0029 0.0042 0.0155
Mycobacterium ulcerans endonuclease IV 0.0077 0.0191 0.2338
Schistosoma mansoni slit 0.0048 0.0101 0.0232
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0016 0.0036
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.006 0.0138 0.0513
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0135 0.6774
Schistosoma mansoni DNA helicase recq5 0.0031 0.0047 0.0109
Loa Loa (eye worm) hypothetical protein 0.0077 0.0191 0.0712
Brugia malayi nuclear receptor RXR 0.0019 0.0009 0.0031
Schistosoma mansoni hypothetical protein 0.005 0.0107 0.0247
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0303 0.3774
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0138 0.4546
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0073 0.0273
Echinococcus multilocularis neuroligin 0.0027 0.0035 0.0026
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0077 0.0191 0.0712
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.0716 0.0708
Loa Loa (eye worm) CUTiclin-Like family member 0.006 0.0138 0.0513
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0062 0.0142 0.0134
Brugia malayi Doublecortin family protein 0.0022 0.0019 0.007
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.006 0.0138 0.0513
Echinococcus granulosus para nitrobenzyl esterase 0.0027 0.0035 0.0026
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0019 0.007
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0009 0.0031
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0073 0.0065
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0062 0.0142 0.0134
Echinococcus multilocularis beta adrenergic receptor kinase 0.0041 0.0079 0.0071
Loa Loa (eye worm) hypothetical protein 0.0029 0.0042 0.0155
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0073 0.0273
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0073 0.0169
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Schistosoma mansoni gliotactin 0.0027 0.0035 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0042 0.0524
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0073 0.0273
Brugia malayi Zona pellucida-like domain containing protein 0.006 0.0138 0.0513
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0067 0.0248
Brugia malayi von Willebrand Factor 0.006 0.0138 0.0513
Mycobacterium ulcerans carboxylesterase, LipT 0.0027 0.0035 0.034
Toxoplasma gondii kringle domain-containing protein 0.0025 0.0027 0.0349
Echinococcus granulosus acetylcholinesterase 0.016 0.0448 0.044
Loa Loa (eye worm) cytochrome P450 family protein 0.0072 0.0176 0.0657
Echinococcus multilocularis acetylcholinesterase 0.016 0.0448 0.044
Toxoplasma gondii PAN domain-containing protein 0.0016 0 0.0006
Schistosoma mansoni acetylcholinesterase 0.0027 0.0035 0.0081
Echinococcus granulosus BC026374 protein S09 family 0.0027 0.0035 0.0026
Leishmania major hypothetical protein, conserved 0.0029 0.0042 0.019
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0009 0.0031
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0077 0.0191 0.5294
Schistosoma mansoni hypothetical protein 0.0759 0.2311 0.5332
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0135 0.3584
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0073 0.0273
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0009 0.002
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0073 0.0273
Schistosoma mansoni hypothetical protein 0.0022 0.0019 0.0044
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0071 0.0163
Echinococcus granulosus transcription factor Dp 1 0.0038 0.007 0.0062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0121 0.0327 0.0318
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.141 0.4335 1
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0101 0.0232
Trichomonas vaginalis DNA helicase recq, putative 0.0034 0.0055 0.0154
Brugia malayi Carboxylesterase family protein 0.0027 0.0035 0.0129
Schistosoma mansoni BC026374 protein (S09 family) 0.0027 0.0035 0.0081
Entamoeba histolytica hypothetical protein 0.0041 0.0079 0.2623
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0303 0.0294
Loa Loa (eye worm) glutamate receptor 0.0092 0.0236 0.0881
Schistosoma mansoni zinc finger protein 0.0019 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0041 0.0079 0.0296
Brugia malayi hypothetical protein 0.0119 0.032 0.1196
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0019 0.0011
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0303 0.3774
Onchocerca volvulus 0.0019 0.0009 0.0027
Brugia malayi laminin alpha chain 0.0048 0.0101 0.0375
Onchocerca volvulus 0.006 0.0138 0.045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0062 0.0143 0.0532
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0079 0.0071
Onchocerca volvulus 0.006 0.0138 0.045
Treponema pallidum exodeoxyribonuclease (exoA) 0.0059 0.0135 0.0151
Schistosoma mansoni ap endonuclease 0.0059 0.0135 0.0312
Brugia malayi nuclear hormone receptor 0.0019 0.0009 0.0031
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0258 0.0753 0.0745
Loa Loa (eye worm) hypothetical protein 0.0115 0.0309 0.1153
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0303 0.0294
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0073 0.0273
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0079 0.0071
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0303 0.0968
Onchocerca volvulus 0.005 0.0107 0.035
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0041 0.0079 0.0296
Toxoplasma gondii PAN domain-containing protein 0.0016 0 0.0006
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0157 0.0363
Onchocerca volvulus 0.0115 0.0309 0.1011
Loa Loa (eye worm) hypothetical protein 0.0038 0.0071 0.0263
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0079 0.0183
Echinococcus multilocularis expressed protein 0.0805 0.2452 0.2445
Schistosoma mansoni cell polarity protein 0.0048 0.0101 0.0232
Brugia malayi PXA domain containing protein 0.0041 0.0079 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0126 0.0343 0.0792
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0126 0.0343 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.0233
Onchocerca volvulus 0.0115 0.0309 0.1011
Echinococcus granulosus tumor protein p63 0.0392 0.117 0.1163
Brugia malayi hypothetical protein 0.0021 0.0016 0.0057
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0157 0.5201
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0135 0.1628
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0031 0.0047 0.0175
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0079 0.0183
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Brugia malayi cytoplasmic intermediate filament protein 0.0062 0.0143 0.0532
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0036 0.0064 0.0479
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0073 0.0239
Echinococcus granulosus lamin 0.0115 0.0309 0.03
Schistosoma mansoni hypothetical protein 0.0189 0.0538 0.1241
Brugia malayi nuclear hormone receptor 0.0039 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.0048 0.0101 0.0375
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0269 0.0788 0.078
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0024 0.0024 0.0088
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0034 0.0055 0.0512
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0027 0.0101
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0071 0.0567
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0019 0.0008 0.0026
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.003
Brugia malayi hypothetical protein 0.0042 0.0081 0.0301
Entamoeba histolytica hypothetical protein 0.0042 0.0081 0.267
Onchocerca volvulus 0.0126 0.0343 0.1125
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0287 0.0841 0.0834
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0157 0.1709
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0014 0.0044
Trichomonas vaginalis spcc417.12 protein, putative 0.0027 0.0035 0.0087
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0073 0.0239
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0046 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0684 0.2077 0.7771
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0047 0.0599
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0042 0.1322
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Brugia malayi hypothetical protein 0.0041 0.0079 0.0296
Brugia malayi hypothetical protein 0.0021 0.0016 0.0057
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0079 0.0071
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0019 0.0011
Loa Loa (eye worm) carboxylesterase 0.0027 0.0035 0.0129
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0071 0.11
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0079 0.0296
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0079 0.0071
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0303 0.1131
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0073 0.0273
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0079 0.0183
Echinococcus multilocularis carboxylesterase 5A 0.016 0.0448 0.044
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0046 0.2955
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.0004 0.001
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0019 0.0011
Brugia malayi Zona pellucida-like domain containing protein 0.006 0.0138 0.0513
Schistosoma mansoni thyroid hormone receptor 0.0326 0.0964 0.2224
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0067 0.0248
Echinococcus granulosus carboxylesterase 5A 0.016 0.0448 0.044
Echinococcus multilocularis tumor protein p63 0.0392 0.117 0.1163
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0303 0.0968
Entamoeba histolytica hypothetical protein 0.0042 0.0081 0.267
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0073 0.0273
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0009 0.0031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0071 0.1567
Mycobacterium ulcerans aldehyde dehydrogenase 0.0269 0.0788 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0031 0.0047 0.0039
Loa Loa (eye worm) hypothetical protein 0.0021 0.0016 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0071 0.0204
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Echinococcus granulosus acetylcholinesterase 0.016 0.0448 0.044
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0303 0.0698
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0079 0.0071
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0073 0.0065
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0083 0.0209 0.0781
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0135 0.0127
Echinococcus granulosus voltage dependent calcium channel subunit 0.147 0.4521 0.4517
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0071 0.0263
Loa Loa (eye worm) hypothetical protein 0.0031 0.0047 0.0175
Trichomonas vaginalis set domain proteins, putative 0.0996 0.3048 1
Echinococcus multilocularis tissue type plasminogen activator 0.0025 0.0027 0.0019
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.003
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0073 0.0169
Brugia malayi hypothetical protein 0.0022 0.0019 0.007
Brugia malayi hypothetical protein 0.0022 0.0019 0.007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0027 0.0035 0.0081
Echinococcus multilocularis acetylcholinesterase 0.016 0.0448 0.044
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0073 0.0273
Schistosoma mansoni lamin 0.0115 0.0309 0.0712
Loa Loa (eye worm) intermediate filament protein 0.0115 0.0309 0.1153
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0113 0.0302 0.0293
Brugia malayi 6-phosphofructokinase 0.0113 0.0303 0.1131
Plasmodium vivax hypothetical protein, conserved 0.006 0.0138 0.3653
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0009 0.002
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0031 0.0047 0.0039
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0047 0.0175
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0269 0.0788 0.078
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0073 0.0065
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0079 0.0071
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0258 0.0753 0.1738
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0025 0.0027 0.0254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0073 0.0273
Schistosoma mansoni rab6-interacting 0.0022 0.0019 0.0044
Brugia malayi steroid hormone receptor 0.0039 0.0073 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.0041 0.0079 0.0183
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0009 0.0031
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0079 0.0183
Schistosoma mansoni metabotropic glutamate receptor 0.0045 0.009 0.0207
Echinococcus granulosus bloom syndrome protein 0.0044 0.0086 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0073 0.0273
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0145
Loa Loa (eye worm) hypothetical protein 0.0027 0.0035 0.0129
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0027 0.0035 0.0087
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0009 0.0031
Onchocerca volvulus 0.0027 0.0035 0.0113
Onchocerca volvulus 0.0027 0.0035 0.0113
Brugia malayi von Willebrand factor type A domain containing protein 0.006 0.0138 0.0513
Schistosoma mansoni loxhd1 0.0022 0.0019 0.0044
Schistosoma mansoni ap endonuclease 0.0059 0.0135 0.0312
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0027 0.0035 0.0081
Brugia malayi Carboxylesterase family protein 0.0027 0.0035 0.0129
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0081 0.0186
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0303 1
Echinococcus granulosus neuroligin 0.0027 0.0035 0.0026
Loa Loa (eye worm) hypothetical protein 0.0113 0.0302 0.1128
Entamoeba histolytica hypothetical protein 0.0041 0.0079 0.2623
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0016 0.0057
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0079 0.0071
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0079 0.0183
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0073 0.0065
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0303 0.0968
Brugia malayi Cache domain containing protein 0.0651 0.1974 0.7388
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0101 0.0375
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0047 0.0599
Echinococcus multilocularis expressed protein 0.0037 0.0067 0.0058
Schistosoma mansoni blooms syndrome DNA helicase 0.0028 0.0037 0.0086
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0711 0.2161 0.4985
Brugia malayi EGF-like domain containing protein 0.0048 0.0101 0.0375
Loa Loa (eye worm) hypothetical protein 0.0246 0.0716 0.2679
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0073 0.0273
Brugia malayi nuclear receptor NHR-67 0.0019 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0073 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0079 0.0233
Brugia malayi hypothetical protein 0.0027 0.0035 0.0129
Toxoplasma gondii PAN domain-containing protein 0.0016 0 0.0006
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0079 0.0296
Plasmodium falciparum thrombospondin-related anonymous protein 0.006 0.0138 0.6901
Plasmodium vivax thrombospondin-related anonymous protein 0.006 0.0138 0.3653
Schistosoma mansoni serine-rich repeat protein 0.0759 0.2311 0.5332
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0135 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0107 0.0399
Trichomonas vaginalis DNA helicase recq1, putative 0.0044 0.0086 0.0256
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0014 0.0071
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0126 0.0343 0.0335
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0073 0.0169
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0031 0.0047 0.0175
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0009 0.0031
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.0716 0.0708
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0073 0.0169
Treponema pallidum methyl-accepting chemotaxis protein (mcp2-1) 0.1932 0.5956 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0135 0.1419
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.006 0.0138 0.0513
Brugia malayi hypothetical protein 0.0262 0.0767 0.2868
Echinococcus granulosus beta-adrenergic receptor kinase 0.0041 0.0079 0.0071
Onchocerca volvulus 0.006 0.0138 0.045
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0046 0.0123
Schistosoma mansoni hypothetical protein 0.0042 0.0081 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0303 0.0968
Brugia malayi Protein kinase domain containing protein 0.0025 0.0027 0.0101
Toxoplasma gondii hypothetical protein 0.0016 0 0.0006
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0079 0.0183
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0303 0.0698
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0269 0.0788 1
Schistosoma mansoni metabotropic glutamate receptor 0.0077 0.019 0.0438
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Echinococcus multilocularis lamin dm0 0.0115 0.0309 0.03
Loa Loa (eye worm) DR-78 0.0019 0.0009 0.0031
Loa Loa (eye worm) hypothetical protein 0.0651 0.1974 0.7388
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0875 0.2672 1
Brugia malayi intermediate filament protein 0.0115 0.0309 0.1153
Trichomonas vaginalis rotamase, putative 0.0037 0.0067 0.0192
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0126 0.0343 0.0792
Echinococcus granulosus RUN 0.0022 0.0019 0.0011
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0126 0.0343 0.4354
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0258 0.0753 0.2819
Brugia malayi Carboxylesterase family protein 0.016 0.0448 0.1677
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0056 0.0124 0.0115
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0016 0 0.0006
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0079 0.0071
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0157 0.4722
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0073 0.0273
Schistosoma mansoni cpg binding protein 0.0034 0.0056 0.0129
Plasmodium falciparum von Willebrand factor A domain-related protein 0.006 0.0138 0.6901
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0135 0.3586
Brugia malayi phosphofructokinase 0.0113 0.0303 0.1131
Schistosoma mansoni hypothetical protein 0.006 0.0138 0.0317
Schistosoma mansoni neuroligin 3 (S09 family) 0.0027 0.0035 0.0081
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0101 0.0375
Loa Loa (eye worm) carboxylesterase 0.0027 0.0035 0.0129
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0904 0.276 0.2754
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.006 0.0138 0.3653
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0042 0.0532
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0287 0.0841 0.0834
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0031
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0079 0.0071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0025 0.0029 0.0371
Loa Loa (eye worm) hypothetical protein 0.006 0.0138 0.0513
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0036 0.0064 0.2113
Toxoplasma gondii microneme protein MIC17A 0.0016 0 0.0006
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0077 0.0191 0.2338
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0046 0.1519
Entamoeba histolytica hypothetical protein, conserved 0.006 0.0138 0.4546
Brugia malayi metabotropic glutamate receptor type 2 0.0045 0.009 0.0335
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0135 0.0505
Echinococcus multilocularis RUN 0.0022 0.0019 0.0011
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0046 0.0583
Schistosoma mansoni thyroid hormone receptor 0.0326 0.0964 0.2224
Loa Loa (eye worm) RecQ helicase 0.0044 0.0086 0.0322
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0303 1
Schistosoma mansoni survival motor neuron protein 0.005 0.0107 0.0247
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0079 0.0296
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0073 0.0273
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0157 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0073 0.0273
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0135 0.4473
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0031 0.0047 0.0039
Brugia malayi Pre-SET motif family protein 0.0126 0.0343 0.1283
Onchocerca volvulus 0.006 0.0138 0.045
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0073 0.0169
Schistosoma mansoni nuclear receptor 0.0019 0.0009 0.002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0073 0.0273
Plasmodium falciparum cysteine repeat modular protein 1 0.0025 0.0027 0.048
Echinococcus multilocularis voltage dependent calcium channel subunit 0.3233 1 1
Echinococcus multilocularis para nitrobenzyl esterase 0.0027 0.0035 0.0026
Mycobacterium ulcerans hypothetical protein 0.002 0.0014 0.0071
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0073 0.0169
Brugia malayi follicle stimulating hormone receptor 0.0246 0.0716 0.268

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 30 uM Cytotoxicity of the compound measured against human T-cells ChEMBL. 11356112
IC50 (binding) > 30 uM In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate ChEMBL. 11356112
IC50 (functional) > 30 uM In vitro inhibition of human T-cell proliferation ChEMBL. 11356112
IC50 (binding) > 30 uM In vitro inhibitory activity against the cytosolic portion of CD45 protein-tyrosine phosphatase using pNPP as the substrate ChEMBL. 11356112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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