Detailed information for compound 799154

Basic information

Technical information
  • TDR Targets ID: 799154
  • Name: N-(2,2-dimethoxyethyl)-2,1,3-benzoxadiazole-7 -sulfonamide
  • MW: 287.292 | Formula: C10H13N3O5S
  • H donors: 1 H acceptors: 4 LogP: 0.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(CNS(=O)(=O)c1cccc2c1non2)OC
  • InChi: 1S/C10H13N3O5S/c1-16-9(17-2)6-11-19(14,15)8-5-3-4-7-10(8)13-18-12-7/h3-5,9,11H,6H2,1-2H3
  • InChiKey: ZFLFVZQDTJYDKG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,2-dimethoxyethyl)benzofurazan-4-sulfonamide
  • SMR000313821
  • MLS000675099
  • N-(2,2-dimethoxyethyl)-2,1,3-benzoxadiazole-4-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.0258 0.2042 0.204
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0183 0.018
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0022 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0175 0.0192
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0109 0.0771 0.0761
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0183 0.018
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0037 0.0006
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.011 0.0703
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0183 0.018
Mycobacterium leprae Polyketide synthase Pks13 0.0081 0.0529 0.0569
Loa Loa (eye worm) hypothetical protein 0.0103 0.0725 0.0722
Schistosoma mansoni coup transcription factor 0.004 0.0183 0.0195
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0144 0.0153
Schistosoma mansoni hypothetical protein 0.0082 0.0538 0.0579
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0109 0.0771 0.0846
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.011 0.5
Schistosoma mansoni ap endonuclease 0.0039 0.0175 0.0186
Onchocerca volvulus 0.0109 0.0773 0.5056
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1415 0.1529
Echinococcus multilocularis flap endonuclease 1 0.0025 0.006 0.0061
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0183 0.1185
Mycobacterium ulcerans thioesterase 0.0045 0.0225 0.0214
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0538 0.0579
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0175 0.0172
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0052 0.0288 0.0316
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0103 0.0725 0.8681
Brugia malayi 6-phosphofructokinase 0.0116 0.0833 0.0831
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0183 0.0195
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0833 1
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0773 0.0805
Mycobacterium ulcerans polyketide synthase Pks9 0.0036 0.0146 0.0135
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0103 0.0725 0.9329
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0103 0.0725 0.8638
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0183 0.018
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0103 0.0725 0.0715
Brugia malayi Cytochrome P450 family protein 0.0023 0.0037 0.0034
Leishmania major acetyl-CoA synthetase, putative 0.0103 0.0725 0.0763
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0103 0.0725 0.0722
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0022 0.0019
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0103 0.0725 0.0753
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0022 0.0021
Mycobacterium ulcerans polyketide synthase 0.0054 0.0302 0.0291
Mycobacterium ulcerans Type I modular polyketide synthase 0.0054 0.0302 0.0291
Plasmodium vivax ataxin-2 like protein, putative 0.0079 0.0515 0.638
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0197 0.1928
Leishmania major fatty acid transporter protein-like protein 0.1086 0.9117 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0183 0.018
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0175 0.0186
Entamoeba histolytica hypothetical protein 0.0035 0.0139 0.1557
Brugia malayi Bromodomain containing protein 0.0038 0.0164 0.0161
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0103 0.0725 0.8638
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0022 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0125 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1415 0.1529
Leishmania major hypothetical protein, conserved 0.0109 0.0773 0.0816
Mycobacterium ulcerans hypothetical protein 0.0109 0.0773 0.0763
Echinococcus granulosus muscleblind protein 0.0308 0.2474 0.2675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.1415 0.1529
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.011 0.0703
Loa Loa (eye worm) hypothetical protein 0.004 0.0184 0.0181
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0037 0.0026
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0175 0.1487
Echinococcus granulosus zinc finger protein 0.0019 0.0006 0.0004
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.006 0.0031
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0109 0.0771 0.0761
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0103 0.0725 0.0784
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0103 0.0725 0.0715
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Mycobacterium ulcerans acetyl-CoA synthetase 0.0103 0.0725 0.0715
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0833 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0773 0.077
Brugia malayi phosphofructokinase 0.0116 0.0833 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0183 0.018
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0103 0.0725 0.0763
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0183 0.1185
Toxoplasma gondii type I fatty acid synthase, putative 0.0038 0.0169 0.1538
Brugia malayi hypothetical protein 0.0079 0.0515 0.0512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1415 0.1529
Echinococcus multilocularis zinc finger protein 0.0019 0.0006 0.0004
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Leishmania major 4-coumarate:coa ligase-like protein 0.0103 0.0725 0.0763
Brugia malayi PHD-finger family protein 0.0025 0.0051 0.0048
Echinococcus multilocularis geminin 0.088 0.7355 0.7959
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0282 0.0279
Loa Loa (eye worm) hypothetical protein 0.0079 0.0515 0.0512
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.011 0.0648
Mycobacterium tuberculosis Probable lipase LipE 0.0109 0.0773 0.0848
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0725 0.0722
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.011 0.0648
Brugia malayi hypothetical protein 0.0021 0.0022 0.0019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.0302 0.0331
Loa Loa (eye worm) hypothetical protein 0.0103 0.0725 0.0722
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0054 0.0302 0.0319
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.1086 0.9117 1
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.119 1 1
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0044 0.0218 0.0239
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0103 0.0725 0.0715
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0054 0.0302 0.0331
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.1999 0.2161
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0833 0.0871
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0773 0.0805
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0175 0.0157
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0103 0.0725 0.0715
Loa Loa (eye worm) hypothetical protein 0.0082 0.0538 0.0535
Loa Loa (eye worm) hypothetical protein 0.0103 0.0725 0.0722
Loa Loa (eye worm) hypothetical protein 0.0109 0.0773 0.077
Loa Loa (eye worm) hypothetical protein 0.0109 0.0773 0.077
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0015 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0019
Loa Loa (eye worm) beta-lactamase 0.0109 0.0773 0.077
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0103 0.0725 0.0715
Leishmania major acetyl-CoA synthetase, putative 0.0103 0.0725 0.0763
Brugia malayi beta-lactamase family protein 0.0109 0.0773 0.077
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0538 0.0579
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0183 0.0195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0011 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0538 0.0535
Onchocerca volvulus 0.0154 0.1155 0.7564
Mycobacterium tuberculosis Conserved protein 0.0109 0.0773 0.0848
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0833 0.0831
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.1415 0.1412
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.011 0.12
Brugia malayi hypothetical protein 0.0051 0.0276 0.0273
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0022 0.0021
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.011 0.0648
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0183 0.0195
Leishmania major 4-coumarate:coa ligase-like protein 0.0103 0.0725 0.0763
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0773 0.0834
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0183 0.0195
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.11 0.924 1
Brugia malayi beta-lactamase family protein 0.0109 0.0773 0.077
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0773 0.9217
Echinococcus granulosus beta LACTamase domain containing family member 0.0109 0.0773 0.0834
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0109 0.0773 0.077
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0054 0.0302 0.0291
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0109 0.0771 0.0846
Mycobacterium ulcerans beta-lactamase 0.0109 0.0773 0.0763
Schistosoma mansoni hypothetical protein 0.0082 0.0538 0.0579
Echinococcus granulosus flap endonuclease 1 0.0025 0.006 0.0061
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0031 0.0103 0.0113
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0057 0.033 0.0351
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0154 0.1155 0.1152
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0344 0.0369
Loa Loa (eye worm) hypothetical protein 0.003 0.01 0.0097
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.0807 0.087
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.1415 0.1412
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0109 0.0773 0.0848
Echinococcus granulosus long chain fatty acid transport protein 4 0.11 0.924 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0116 0.0833 0.0903
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0039 0.0172 0.0189
Loa Loa (eye worm) fatty acid synthase 0.0053 0.0296 0.0293
Brugia malayi nuclear hormone receptor 0.004 0.0183 0.018
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.011 0.0754
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0103 0.0725 0.0753
Trichomonas vaginalis antibiotic synthetase, putative 0.0103 0.0725 0.8599
Toxoplasma gondii type I fatty acid synthase, putative 0.0072 0.0453 0.5518
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.2042 0.204
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0175 0.1487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0183 0.0195
Brugia malayi hypothetical protein 0.0253 0.1999 0.1997
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.011 0.0648
Echinococcus granulosus 6 phosphofructokinase 0.0116 0.0833 0.0899
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.2042 0.204
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0725 0.0722
Mycobacterium tuberculosis Conserved protein 0.0109 0.0773 0.0848
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0183 0.018
Brugia malayi beta-lactamase 0.0109 0.0773 0.077
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0022 0.0019
Schistosoma mansoni hypothetical protein 0.088 0.7355 0.7959
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0725 0.0722
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0019
Leishmania major ATP-dependent phosphofructokinase 0.0116 0.0833 0.0882
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0043 0.0212 0.0221
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0175 0.0186
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0833 1
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.0105 0.0737 0.0735
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0057 0.033 0.0362
Loa Loa (eye worm) hypothetical protein 0.0038 0.0164 0.0162
Schistosoma mansoni hypothetical protein 0.088 0.7355 0.7959
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable esterase LipL 0.0109 0.0773 0.0848
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.011 0.0648
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0109 0.0771 0.0761
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1415 0.1529
Schistosoma mansoni hypothetical protein 0.0176 0.1346 0.1454
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0057 0.033 0.0351
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0175 0.1729
Onchocerca volvulus 0.0109 0.0773 0.5056
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Schistosoma mansoni acetyl-CoA synthetase 0.0103 0.0725 0.0782
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0725 0.0722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0109 0.0773 0.0834
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0807 0.0797
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0183 0.0195
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.011 0.4358
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Brugia malayi Bromodomain containing protein 0.0074 0.0472 0.047
Onchocerca volvulus 0.0109 0.0773 0.5056
Entamoeba histolytica acyl-CoA synthetase, putative 0.0103 0.0725 0.8681
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0113 0.0807 0.0885
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0103 0.0725 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0183 0.018
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0109 0.0771 0.0835
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0144 0.0152
Onchocerca volvulus 0.004 0.0183 0.1185
Schistosoma mansoni flap endonuclease-1 0.0023 0.0039 0.0039
Loa Loa (eye worm) hypothetical protein 0.0308 0.2474 0.2472
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0183 0.018
Loa Loa (eye worm) hypothetical protein 0.0253 0.1999 0.1997
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0103 0.0725 0.0795
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0103 0.0725 0.0715
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0043 0.0212 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0057 0.033 0.032
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0175 0.0897
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0183 0.1185
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0833 0.0899
Loa Loa (eye worm) oxidoreductase 0.0103 0.0725 0.0722
Schistosoma mansoni thyroid hormone receptor 0.004 0.0183 0.0195
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0103 0.0725 0.0795
Brugia malayi nuclear receptor NHR-88 0.004 0.0183 0.018
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0538 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0183 0.018
Brugia malayi 6-phosphofructokinase 0.0116 0.0833 0.0831
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.1415 0.1529
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0515 0.0524
Loa Loa (eye worm) hypothetical protein 0.0103 0.0725 0.0722
Onchocerca volvulus 0.0052 0.0282 0.1832
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0344 0.0369
Mycobacterium tuberculosis Probable lipase LipD 0.0109 0.0773 0.0848
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0175 0.0172
Echinococcus multilocularis muscleblind protein 0.0308 0.2474 0.2675
Mycobacterium tuberculosis Probable hydrolase 0.0109 0.0773 0.0848
Entamoeba histolytica hypothetical protein 0.0035 0.0139 0.1557
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0081 0.0529 0.0581
Toxoplasma gondii ABC1 family protein 0.0109 0.0773 1
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.1999 0.2161
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0725 0.0795
Echinococcus granulosus AMP dependent ligase 0.002 0.0011 0.0009
Mycobacterium ulcerans Type I modular polyketide synthase 0.0054 0.0302 0.0291
Schistosoma mansoni FFA transport protein 0.11 0.924 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0183 0.018
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0031 0.0031
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0103 0.0725 0.0784
Mycobacterium ulcerans Type I modular polyketide synthase 0.0054 0.0302 0.0291
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0773 0.9217
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.006 0.0057
Loa Loa (eye worm) hypothetical protein 0.0103 0.0725 0.0722
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0139 0.0147
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0183 0.0195
Brugia malayi AMP-binding enzyme family protein 0.0031 0.0106 0.0103
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0113 0.0807 0.087
Schistosoma mansoni hypothetical protein 0.0082 0.0538 0.0579
Mycobacterium tuberculosis Conserved protein 0.0109 0.0773 0.0848
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0035 0.014 0.1131
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0183 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.1346 0.1344
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0144 0.0153
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0725 0.0795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0183 0.018
Plasmodium vivax hypothetical protein, conserved 0.0109 0.0773 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0139 0.0147
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0103 0.0725 0.0753
Trypanosoma brucei PAB1-binding protein , putative 0.0079 0.0515 0.5996
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0183 0.018
Entamoeba histolytica hypothetical protein 0.0035 0.0139 0.1557
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0022 0.0028 0.0031
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0183 0.0195
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0175 0.0155
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0833 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0139 0.0147
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0013
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0057 0.033 0.0362
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0183 0.0195
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0116 0.0833 0.0914
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0175 0.1727
Schistosoma mansoni ap endonuclease 0.0039 0.0175 0.0186
Trypanosoma cruzi PAB1-binding protein , putative 0.0079 0.0515 0.0524
Brugia malayi Muscleblind-like protein 0.0308 0.2474 0.2472
Entamoeba histolytica hypothetical protein 0.0035 0.0139 0.1557
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0113 0.0807 0.0804
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0183 0.0195
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0175 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.1086 0.9117 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0183 0.0195
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0103 0.0725 0.0715
Schistosoma mansoni bromodomain containing protein 0.0062 0.0374 0.0402
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0183 0.018
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0833 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0538 0.0579
Brugia malayi AMP-binding enzyme family protein 0.0103 0.0725 0.0722
Mycobacterium ulcerans polyketide synthase Pks13 0.0081 0.0529 0.0519
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0773 0.9217
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0773 0.9239
Mycobacterium tuberculosis Probable thioesterase TesA 0.0045 0.0225 0.0247
Loa Loa (eye worm) 6-phosphofructokinase 0.0116 0.0833 0.0831
Echinococcus granulosus FTZ F1 alpha 0.004 0.0183 0.0195
Mycobacterium ulcerans acyl-CoA synthetase 0.0109 0.0771 0.0761
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.006 0.0281
Mycobacterium leprae Probable lipase LipE 0.0109 0.0773 0.0837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0183 0.018
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0109 0.0771 0.0846
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0113 0.0807 0.0797
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0183 0.018
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.011 0.0703
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0037 0.0034
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0043 0.0212 0.0201
Trichomonas vaginalis penicillin-binding protein, putative 0.0109 0.0773 0.9217
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0144 0.0152
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.6659 0.7206
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0154 0.1155 0.1267
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0103 0.0725 0.0795
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0183 0.0195
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0175 0.1613
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.11 0.924 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0103 0.0725 0.8599
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0109 0.0771 0.0769
Echinococcus multilocularis 6 phosphofructokinase 0.0116 0.0833 0.0899
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0109 0.0773 0.0848
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.011 0.0648
Entamoeba histolytica Flap nuclease, putative 0.0025 0.006 0.059
Mycobacterium ulcerans lipase LipD 0.0109 0.0773 0.0763
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.0109 0.0773 0.077
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0515 0.6839
Toxoplasma gondii propionate-CoA ligase 0.0103 0.0725 0.9329
Toxoplasma gondii LsmAD domain-containing protein 0.0079 0.0515 0.638
Onchocerca volvulus 0.0103 0.0725 0.4742
Echinococcus multilocularis muscleblind protein 1 0.0308 0.2474 0.2675
Schistosoma mansoni nuclear hormone receptor 0.004 0.0183 0.0195
Echinococcus multilocularis long chain fatty acid transport protein 4 0.11 0.924 1
Loa Loa (eye worm) phosphofructokinase 0.0116 0.0833 0.0831
Schistosoma mansoni survival motor neuron protein 0.0052 0.0282 0.0302
Brugia malayi ecdysteroid receptor 0.004 0.0183 0.018
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0183 0.0195
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0102 0.0714 0.0711
Entamoeba histolytica acyl-CoA synthetase, putative 0.0109 0.0771 0.9246
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0031 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.1415 0.1529
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0109 0.0773 0.0848
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0183 0.0195
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Echinococcus multilocularis beta LACTamase domain containing family member 0.0109 0.0773 0.0834
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.006 0.003
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0116 0.0833 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0057 0.033 0.0362
Brugia malayi Cytochrome P450 family protein 0.0033 0.0125 0.0122
Mycobacterium leprae conserved hypothetical protein 0.0109 0.0773 0.0837
Entamoeba histolytica acyl-coA synthetase, putative 0.0103 0.0725 0.8681
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0725 0.0795
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0105 0.0742 0.0739
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0113 0.0807 0.087
Mycobacterium leprae Probable polyketide synthase Pks1 0.0057 0.033 0.0351
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.2042 0.204
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0183 0.018
Schistosoma mansoni hypothetical protein 0.0052 0.0282 0.0302
Mycobacterium ulcerans hypothetical protein 0.0103 0.0725 0.0715
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0103 0.0725 0.9329
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0183 0.018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0183 0.018
Brugia malayi nuclear receptor RXR 0.0021 0.0022 0.0019
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0109 0.0773 0.0763
Loa Loa (eye worm) acyl carrier protein 0.0025 0.0053 0.005
Onchocerca volvulus 0.0103 0.0725 0.4742
Leishmania major hypothetical protein, conserved 0.0079 0.0515 0.0532
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0031 0.0031
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0037 0.0034
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0057 0.033 0.032
Mycobacterium ulcerans thioesterase TesA 0.0045 0.0225 0.0214
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0183 0.0195
Trichomonas vaginalis esterase, putative 0.0109 0.0773 0.9217
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.011 0.0754
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0183 0.018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0183 0.0195
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0081 0.0529 0.0581
Onchocerca volvulus 0.0116 0.0836 0.5474
Brugia malayi Cytochrome P450 family protein 0.0023 0.0037 0.0034
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0116 0.0833 1
Echinococcus granulosus GPCR family 2 0.0082 0.0538 0.0579
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0109 0.0771 0.0846
Leishmania major cytochrome p450-like protein 0.0023 0.0037 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0109 0.0773 0.9217
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0538 0.0579
Echinococcus granulosus geminin 0.088 0.7355 0.7959
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Schistosoma mansoni zinc finger protein 0.0019 0.0006 0.0004
Mycobacterium ulcerans polyketide synthase 0.0057 0.033 0.032
Loa Loa (eye worm) hypothetical protein 0.0109 0.0773 0.077
Onchocerca volvulus 0.0197 0.1526 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0183 0.0195
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0103 0.0725 0.0784
Brugia malayi steroid hormone receptor 0.004 0.0183 0.018
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.1884 0.1882
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.011 0.5
Loa Loa (eye worm) AMP-binding enzyme family protein 0.119 1 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0045 0.0225 0.0235
Echinococcus multilocularis GPCR, family 2 0.0082 0.0538 0.0579
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.1884 0.1882
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0538 0.0535
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0175 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0079 0.0515 0.6839
Toxoplasma gondii exonuclease III APE 0.0039 0.0175 0.1613
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0037 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0019
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0089 0.0602 0.0661
Schistosoma mansoni hypothetical protein 0.0035 0.0144 0.0152
Mycobacterium ulcerans esterase/lipase LipP 0.0109 0.0773 0.0763
Entamoeba histolytica phosphofructokinase, putative 0.0116 0.0833 1
Schistosoma mansoni 6-phosphofructokinase 0.0116 0.0833 0.0899
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0183 0.0195
Brugia malayi hypothetical protein 0.0035 0.0139 0.0136
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0176 0.1346 0.1344
Schistosoma mansoni thyroid hormone receptor 0.004 0.0183 0.0195
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.011 0.0703
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0175 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0725 0.0795
Echinococcus multilocularis AMP dependent ligase 0.002 0.0011 0.0009
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0054 0.0302 0.0319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0109 0.0773 0.077
Onchocerca volvulus Fatty acid synthase homolog 0.0097 0.0671 0.4388
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0697 0.579 0.6351
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.011 0.0703
Leishmania major 4-coumarate:coa ligase-like protein 0.0103 0.0725 0.0763
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0103 0.0725 0.0782
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0054 0.0302 0.0299
Brugia malayi hypothetical protein 0.0021 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0042 0.02 0.0198
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0054 0.0302 0.0331
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0103 0.0725 0.0784
Loa Loa (eye worm) hypothetical protein 0.0308 0.2474 0.2472
Plasmodium vivax acetyl-CoA synthetase, putative 0.0103 0.0725 0.9329
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0183 0.018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0183 0.0195
Loa Loa (eye worm) hypothetical protein 0.007 0.0436 0.0434
Trichomonas vaginalis phosphofructokinase, putative 0.0116 0.0833 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0103 0.0725 0.0795
Mycobacterium ulcerans 6-phosphofructokinase 0.0116 0.0833 0.0823
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0109 0.0771 0.0761
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0113 0.0807 0.0853
Loa Loa (eye worm) hypothetical protein 0.004 0.0183 0.018
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0036 0.0146 0.0135
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0103 0.0725 0.0782
Brugia malayi Flap endonuclease-1 0.0025 0.006 0.0057
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0183 0.0195
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0036 0.0146 0.0148
Loa Loa (eye worm) hypothetical protein 0.0109 0.0773 0.077
Brugia malayi AMP-binding enzyme family protein 0.0154 0.1155 0.1152
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0175 0.0155
Schistosoma mansoni hypothetical protein 0.0082 0.0538 0.0579
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0037 0.0034
Schistosoma mansoni hypothetical protein 0.0035 0.0139 0.0147
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0103 0.0725 0.0753
Mycobacterium ulcerans acyl-CoA synthetase 0.0103 0.0725 0.0715
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0052 0.0288 0.0316
Brugia malayi MH2 domain containing protein 0.0239 0.1884 0.1882
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0175 0.1989
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.011 0.0648

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0052 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.0657 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 125.8925 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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