Detailed information for compound 80866

Basic information

Technical information
  • TDR Targets ID: 80866
  • Name: 2-amino-5-bromo-6-(2,3-difluorophenyl)-1H-pyr imidin-4-one
  • MW: 302.075 | Formula: C10H6BrF2N3O
  • H donors: 2 H acceptors: 3 LogP: 2.39 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(O)c(c(n1)c1cccc(c1F)F)Br
  • InChi: 1S/C10H6BrF2N3O/c11-6-8(15-10(14)16-9(6)17)4-2-1-3-5(12)7(4)13/h1-3H,(H3,14,15,16,17)
  • InChiKey: BSFOJQJGMOJFII-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-azanyl-5-bromo-6-(2,3-difluorophenyl)-1H-pyrimidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0226 0.0226
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0118 0.1916
Leishmania major hypothetical protein, conserved 0.0036 0.0178 0.0414
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0184 0.0184
Mycobacterium ulcerans lipase LipD 0.0036 0.0178 0.4103
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0039 0.0199 0.0484
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0169 0.0169
Onchocerca volvulus 0.0017 0.0053 0.0165
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0053 0.2605
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0178 0.0178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.037 0.119
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0342 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0279 0.0908
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0118 0.1916
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0039 0.0199 0.0197
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Brugia malayi Pre-SET motif family protein 0.0422 0.2716 0.2716
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0199 0.0199
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0342 0.0342
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.037 0.037
Schistosoma mansoni coup transcription factor 0.0065 0.037 0.037
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0145 0.0145
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Plasmodium vivax vivapain-2 0.0017 0.0053 0.1543
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0145 0.0145
Echinococcus granulosus FTZ F1 alpha 0.0065 0.037 0.037
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.037 0.037
Echinococcus granulosus cathepsin l1 0.0011 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0053 0.017
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0184 0.0184
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0327 0.0327
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0053 0.0165
Plasmodium vivax vivapain-2 0.0017 0.0053 0.1543
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0342 0.2806
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0358 0.1164
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0342 0.0342
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0092 0.0192
Brugia malayi nuclear receptor NHR-88 0.0031 0.0145 0.0145
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.037 0.037
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0199 0.0199
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0119 0.0117
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.1448 0.1446
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0167 0.1039 0.3378
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0145 0.0143
Schistosoma mansoni gliotactin 0.0023 0.0092 0.0092
Echinococcus granulosus heat shock protein 0.0027 0.0118 0.0118
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0145 0.0145
Mycobacterium tuberculosis Carboxylesterase LipT 0.0023 0.0092 0.0192
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0237 0.15 0.1499
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Brugia malayi nuclear hormone receptor 0.0065 0.037 0.037
Onchocerca volvulus 0.0039 0.0199 0.0637
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0118 0.1916
Echinococcus multilocularis lamin 0.0027 0.0119 0.0119
Schistosoma mansoni lipoxygenase 0.011 0.0666 0.0666
Onchocerca volvulus 0.0023 0.0092 0.0293
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0039 0.0199 0.0199
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0169 0.0169
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0118 0.0384
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0118 0.0376
Brugia malayi hypothetical protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) fibroinase 0.0017 0.0053 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0066 0.0215
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0118 0.5843
Plasmodium falciparum endoplasmin, putative 0.0027 0.0118 0.5843
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0178 0.4103
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0002 0.0002
Schistosoma mansoni pyruvate dehydrogenase 0.045 0.2902 0.2902
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0017 0.0053 0.0051
Onchocerca volvulus 0.0017 0.0053 0.0165
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0118 0.1916
Loa Loa (eye worm) beta-lactamase 0.0036 0.0178 0.0176
Onchocerca volvulus 0.0039 0.0199 0.0637
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.02
Onchocerca volvulus 0.0031 0.0145 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0184 0.0184
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0066 0.1935
Schistosoma mansoni nuclear receptor 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.037 0.119
Echinococcus granulosus carboxylesterase 5A 0.0134 0.0822 0.0822
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0176
Brugia malayi hypothetical protein 0.0039 0.0199 0.0199
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0002 0.0002
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0002
Onchocerca volvulus 0.0036 0.0178 0.0568
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Brugia malayi Pre-SET motif family protein 0.0061 0.0342 0.0342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0178 0.0178
Brugia malayi hypothetical protein 0.0036 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0118 0.0381
Onchocerca volvulus 0.0039 0.0199 0.0637
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0145 0.0145
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.037 0.037
Onchocerca volvulus 0.0039 0.0199 0.0637
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0118 0.038
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0118 0.0384
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0092 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.037 0.037
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0118 0.0381
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0039 0.0199 0.0199
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0118 0.0376
Echinococcus granulosus geminin 0.0347 0.2221 0.2221
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0039 0.0199 0.0199
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0027 0.0118 1
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0039 0.0199 0.0199
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0184 0.0598
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0118 0.0962
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0053 0.0051
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Onchocerca volvulus 0.0039 0.0199 0.0637
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0118 0.1916
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.037 0.037
Brugia malayi N-terminal motif family protein 0.0178 0.1116 0.1116
Leishmania major cathepsin L-like protease 0.0063 0.0358 0.101
Echinococcus multilocularis BC026374 protein (S09 family) 0.0023 0.0092 0.0092
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0178 0.0178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Echinococcus multilocularis 0.0039 0.0199 0.0199
Mycobacterium ulcerans putative regultory protein 0.0027 0.0118 0.1916
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0118 0.038
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0118 0.0384
Entamoeba histolytica cysteine protease, putative 0.0017 0.0053 0.2605
Onchocerca volvulus 0.0039 0.0199 0.0637
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0178 0.0178
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.037 0.037
Entamoeba histolytica heat shock protein 90, putative 0.0027 0.0118 0.5843
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0184 0.0184
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0118 0.0384
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0178 0.5203
Echinococcus multilocularis neuroligin 0.0023 0.0092 0.0092
Schistosoma mansoni rab6-interacting 0.0039 0.0202 0.0202
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0178 0.0578
Onchocerca volvulus 0.0039 0.0199 0.0637
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0279 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.037 0.037
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0066 0.3266
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1437 1
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.037 0.037
Schistosoma mansoni heat shock protein 0.0027 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Brugia malayi hypothetical protein 0.0031 0.0145 0.0145
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0226 0.0729
Onchocerca volvulus 0.0039 0.0202 0.0646
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0039 0.0199 0.9831
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.037 0.037
Schistosoma mansoni BC026374 protein (S09 family) 0.0023 0.0092 0.0092
Onchocerca volvulus 0.0039 0.0199 0.0637
Schistosoma mansoni nuclear hormone receptor 0.0065 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0118 0.1916
Brugia malayi Protein-tyrosine phosphatase 0.0039 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0053 0.0053
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Onchocerca volvulus 0.0039 0.0199 0.0637
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0169 0.0169
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0053 0.0171
Echinococcus granulosus cathepsin l1 0.0017 0.0053 0.0053
Echinococcus granulosus arachidonate 5 lipoxygenase 0.011 0.0666 0.0666
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0184 0.0184
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0118 0.5843
Onchocerca volvulus 0.0039 0.0199 0.0637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0039 0.0199 0.9831
Onchocerca volvulus 0.0039 0.0199 0.0637
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0184 0.0598
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0178 0.0578
Onchocerca volvulus 0.0031 0.0145 0.0463
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Onchocerca volvulus 0.0011 0.0017 0.0049
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0002
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0199 0.0199
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0023 0.0092 0.0092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0066 0.0066
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0202 0.02
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0039 0.0199 0.0199
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0039 0.0199 0.0199
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0169 0.0169
Loa Loa (eye worm) protein tyrosine phosphatase 0.0039 0.0199 0.0197
Brugia malayi intermediate filament protein 0.0027 0.0119 0.0119
Loa Loa (eye worm) carboxylesterase 0.0023 0.0092 0.0091
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0118 0.0384
Schistosoma mansoni hypothetical protein 0.0347 0.2221 0.2221
Loa Loa (eye worm) heat shock protein 90 0.0027 0.0118 0.0117
Echinococcus granulosus lamin 0.0027 0.0119 0.0119
Brugia malayi hypothetical protein 0.0039 0.0199 0.0199
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.037 0.037
Echinococcus multilocularis lamin dm0 0.0027 0.0119 0.0119
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Onchocerca volvulus 0.0039 0.0199 0.0637
Onchocerca volvulus 0.0039 0.0199 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.037 0.0369
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0118 0.0118
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0118 0.038
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0279 0.0279
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Loa Loa (eye worm) protein-tyrosine phosphatase 0.153 1 1
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0145 0.0145
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.037 0.037
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.037 0.037
Schistosoma mansoni ap endonuclease 0.0019 0.0066 0.0066
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0053 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.037 0.0369
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0023 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.037 0.0369
Entamoeba histolytica hypothetical protein 0.0036 0.0178 0.8775
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0023 0.0092 0.0192
Onchocerca volvulus 0.0027 0.0119 0.0379
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.037 0.037
Schistosoma mansoni zinc finger protein 0.0031 0.0145 0.0145
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0002
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0902 0.0902
Brugia malayi nuclear receptor NHR-67 0.0031 0.0145 0.0145
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0118 0.2445
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0178 0.0814
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0145 0.0145
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0053 0.0051
Brugia malayi kinase, mitochondrial precursor 0.0477 0.3076 0.3076
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0002
Echinococcus granulosus neuroligin 0.0023 0.0092 0.0092
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Loa Loa (eye worm) endoplasmin 0.0027 0.0118 0.0117
Onchocerca volvulus 0.0017 0.0053 0.0165
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.037 0.037
Schistosoma mansoni intermediate filament proteins 0.0027 0.0119 0.0119
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0338 0.0944
Brugia malayi Carboxylesterase family protein 0.0134 0.0822 0.0822
Schistosoma mansoni lamin 0.0027 0.0119 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0053 0.017
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0167 0.1039 0.3378
Loa Loa (eye worm) hypothetical protein 0.0027 0.0119 0.0117
Mycobacterium leprae Probable lipase LipE 0.0036 0.0178 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0176
Echinococcus granulosus BC026374 protein S09 family 0.0023 0.0092 0.0092
Onchocerca volvulus 0.0039 0.0199 0.0637
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Schistosoma mansoni protein tyrosine phosphatase 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.0477 0.3076 0.3075
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0279 0.0279
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0178 0.0814
Brugia malayi tailless protein 0.0031 0.0145 0.0145
Brugia malayi Cathepsin L-like precursor 0.0017 0.0053 0.0053
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0118 0.038
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0145 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.153 1 1
Brugia malayi nuclear receptor NHR-88 0.0065 0.037 0.037
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0118 0.0117
Schistosoma mansoni nuclear receptor 0.0031 0.0145 0.0145
Brugia malayi Carboxylesterase family protein 0.0023 0.0092 0.0092
Onchocerca volvulus 0.0065 0.037 0.119
Trichomonas vaginalis esterase, putative 0.0036 0.0178 0.0574
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Trypanosoma cruzi Heat shock protein 83, putative 0.0027 0.0118 0.0384
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.037 0.037
Echinococcus multilocularis carboxylesterase 5A 0.0134 0.0822 0.0822
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Brugia malayi hypothetical protein 0.0039 0.0199 0.0199
Brugia malayi Cathepsin L-like precursor 0.0017 0.0053 0.0053
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0279 0.0908
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0178 0.0578
Onchocerca volvulus 0.0036 0.0178 0.0568
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0202 1
Trichomonas vaginalis endoplasmin, putative 0.0027 0.0118 0.0381
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0178 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0178 0.4103
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.037 0.037
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0118 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Schistosoma mansoni thyroid hormone receptor 0.0065 0.037 0.037
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0066 0.0215
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0902 0.0902
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0118 0.1916
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0017 0.0054
Leishmania major tyrosine specific protein phosphatase, putative 0.0039 0.0199 0.0484
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0202 0.5905
Loa Loa (eye worm) hypothetical protein 0.0061 0.0342 0.034
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0039 0.0202 0.02
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0279 0.0901
Onchocerca volvulus 0.0039 0.0199 0.0637
Schistosoma mansoni endoplasmin 0.0027 0.0118 0.0118
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0118 0.038
Onchocerca volvulus 0.0017 0.0053 0.0165
Brugia malayi Cathepsin L-like precursor 0.0017 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.037 0.037
Plasmodium vivax endoplasmin, putative 0.0027 0.0118 0.3461
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.037 0.037
Onchocerca volvulus 0.0023 0.0092 0.0293
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0039 0.0199 0.0199
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0178 0.0814
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0118 0.5843
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0168
Schistosoma mansoni endoplasmin 0.0027 0.0118 0.0118
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0279 0.0278
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0027 0.0118 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0038 0.0038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Plasmodium vivax heat shock protein 86, putative 0.0027 0.0118 0.3461
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Echinococcus granulosus para nitrobenzyl esterase 0.0023 0.0092 0.0092
Brugia malayi Protein-tyrosine phosphatase 1 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0176
Onchocerca volvulus 0.0039 0.0199 0.0637
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0184 0.0435
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.037 0.037
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0279 0.0908
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Trypanosoma brucei Heat shock protein 83, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Trypanosoma brucei protein kinase, putative 0.0051 0.0279 0.0908
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.1116 0.3598
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0358 0.1164
Trichomonas vaginalis spcc417.12 protein, putative 0.0023 0.0092 0.0298
Schistosoma mansoni pcd6 interacting protein-related 0.0039 0.0199 0.0199
Brugia malayi beta-lactamase 0.0036 0.0178 0.0178
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0118 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Schistosoma mansoni pyruvate dehydrogenase 0.0477 0.3076 0.3076
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0017 0.0829
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0145 0.0463
Brugia malayi Carboxylesterase family protein 0.0134 0.0822 0.0822
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.037 0.037
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0338 0.1984
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0118 0.0384
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0066 0.0066
Echinococcus multilocularis geminin 0.0347 0.2221 0.2221
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0422 0.2716 0.2715
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0338 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0053 0.0053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0145 0.0145
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.037 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0342 0.0342
Loa Loa (eye worm) acetylcholinesterase 1 0.0134 0.0822 0.0821
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0178 0.0814
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Plasmodium vivax SET domain protein, putative 0.0061 0.0342 1
Onchocerca volvulus Bile acid receptor homolog 0.0237 0.15 0.4838
Brugia malayi conserved hypotetical protein 0.0031 0.0145 0.0145
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0199 0.0199
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0477 0.3076 0.3076
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0015
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0118 0.0217
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0024
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0279 0.2291
Onchocerca volvulus 0.0017 0.0053 0.0165
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0039 0.0199 0.0197
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0279 0.0279
Onchocerca volvulus 0.0039 0.0199 0.0637
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0118 0.038
Echinococcus granulosus heat shock protein 90 0.0027 0.0118 0.0118
Brugia malayi hypothetical protein 0.0034 0.0169 0.0169
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0342 0.0342
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0178 0.0814
Brugia malayi Cathepsin L-like precursor 0.0017 0.0053 0.0053
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0202 1
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0039 0.0199 0.0199
Brugia malayi cathepsin L-like precursor 0.0011 0.0017 0.0017
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.037 0.037
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0279 0.0901
Mycobacterium ulcerans hypothetical protein 0.0036 0.0178 0.4103
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Onchocerca volvulus 0.048 0.3099 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0118 0.0384
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0178 0.1116 0.1114
Echinococcus granulosus protein tyrosine phosphatase n9 0.0039 0.0199 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0145 0.0145
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0358 0.1164
Onchocerca volvulus 0.0039 0.0199 0.0637
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Brugia malayi nuclear hormone receptor 0.0031 0.0145 0.0145
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0118 0.5843
Loa Loa (eye worm) carboxylesterase 0.0023 0.0092 0.0091
Echinococcus multilocularis cysteine protease 0.0017 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0168
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0279 0.0908
Mycobacterium tuberculosis Conserved protein 0.0036 0.0178 0.0814
Brugia malayi heat shock protein 90 0.0027 0.0118 0.0118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0178 0.0814
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0039 0.0199 0.9831
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0066 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Brugia malayi hypothetical protein 0.0023 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0114
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0176
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0184 0.0184
Mycobacterium tuberculosis Conserved protein 0.0036 0.0178 0.0814
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0053 0.2605
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Trichomonas vaginalis pten, drome, putative 0.0039 0.0199 0.0642
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0279 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0184 0.0594
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.037 0.0369
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0039 0.0199 0.0647
Mycobacterium tuberculosis Conserved protein 0.0027 0.0118 0.038
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0039 0.0199 0.0199
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0118 0.3461
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0168
Echinococcus multilocularis acetylcholinesterase 0.0134 0.0822 0.0822
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0184 0.0594
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0178 0.0176
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0118 0.0381
Echinococcus multilocularis heat shock protein 90 0.0027 0.0118 0.0118
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0199 0.0199
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0118 0.0384
Trichomonas vaginalis set domain proteins, putative 0.048 0.3099 1
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Schistosoma mansoni ap endonuclease 0.0019 0.0066 0.0066
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0118 0.038
Brugia malayi hypothetical protein 0.0039 0.0199 0.0199
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0178 0.0178
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0002 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.037 0.037
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0119 0.0117
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Echinococcus multilocularis para nitrobenzyl esterase 0.0023 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0118 0.0118
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0226 0.0729
Brugia malayi hypothetical protein 0.0039 0.0202 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.037 0.037
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0178 0.0178
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0193 0.1213 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0002 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.037 0.037
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0145 0.0145
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0053 0.0053
Schistosoma mansoni pyruvate dehydrogenase 0.045 0.2902 0.2902
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.153 1 1
Brugia malayi Carboxylesterase family protein 0.0023 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0134 0.0822 0.0821
Mycobacterium tuberculosis Conserved protein 0.0036 0.0178 0.0814
Brugia malayi Carboxylesterase family protein 0.0023 0.0092 0.0092
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0184 0.0184
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0199 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0118 0.0384
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0118 0.0381
Schistosoma mansoni lipoxygenase 0.0039 0.0202 0.0202
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0066 0.0066
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.037 0.037
Schistosoma mansoni hypothetical protein 0.0347 0.2221 0.2221
Onchocerca volvulus 0.0039 0.0199 0.0637
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0092 0.0092
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0184 0.0598
Mycobacterium ulcerans carboxylesterase, LipT 0.0023 0.0092 0.0966
Brugia malayi Endoplasmin precursor 0.0027 0.0118 0.0118
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0118 0.038
Onchocerca volvulus 0.0039 0.0199 0.0637
Schistosoma mansoni acetylcholinesterase 0.0023 0.0092 0.0092
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Brugia malayi ecdysteroid receptor 0.0237 0.15 0.15
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0012 0.0025 0.0024
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0039 0.0199 0.0199
Toxoplasma gondii exonuclease III APE 0.0019 0.0066 0.0532
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.037 0.037
Mycobacterium ulcerans beta-lactamase 0.0036 0.0178 0.4103
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0053 0.0053
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0145 0.0145
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0039 0.0199 0.0647
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0134 0.0822 0.0822
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0017 0.0017
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0053 0.017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0176
Schistosoma mansoni protein tyrosine phosphatase 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Brugia malayi Cathepsin L-like precursor 0.0011 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0036 0.0178 0.8775
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0134 0.0822 0.0821
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.0092 0.0092
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0145 0.0145
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0027 0.0118 1
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.027 0.0876
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0118 0.1916
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0118 0.1916
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0169 0.0168
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Loa Loa (eye worm) carboxylesterase 0.0134 0.0822 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.037 0.037
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0118 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.037 0.037
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0202 0.9969
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0118 0.5
Toxoplasma gondii heat shock protein HSP90 0.0027 0.0118 0.0962
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0066 0.3266
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.037 0.037
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0118 0.0381
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.037 0.037
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0039 0.0199 0.0199
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0118 0.0962
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0184 0.9097
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0875 0.0875
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0066 0.0064
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0118 0.0118
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0053 0.2605
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0053 0.0053
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0039 0.0199 0.0199
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0002 0.0002
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0118 0.3461
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0118 0.0384
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0178 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.037 0.037
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0118 0.0118
Onchocerca volvulus 0.0039 0.0202 0.0646
Loa Loa (eye worm) hypothetical protein 0.0011 0.0017 0.0015
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0039 0.0202 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.037 0.037
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0118 0.5
Trypanosoma brucei developmentally regulated phosphoprotein 0.0477 0.3076 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0342 0.0342
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0184 0.0184
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0145 0.0145
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0477 0.3076 0.3076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0117
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0118 0.0118
Leishmania major cathepsin L-like protease 0.0063 0.0358 0.101
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0118 0.038
Schistosoma mansoni loxhd1 0.0039 0.0202 0.0202
Echinococcus granulosus intermediate filament protein 0.0027 0.0119 0.0119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0342 0.0342
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Leishmania major DNA topoisomerase ii 0.0027 0.0118 0.0217
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0145 0.0145
Brugia malayi nuclear receptor RXR 0.0034 0.0169 0.0169
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0145 0.0463
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0028 0.0028
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0145 0.0145
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0118 0.038
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0027 0.0118 1
Toxoplasma gondii cathepsin CPL 0.0017 0.0053 0.0421
Trypanosoma brucei protein tyrosine phosphatase 1 0.0039 0.0199 0.0647
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0338 0.0338
Onchocerca volvulus 0.0039 0.0199 0.0637
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0039 0.0199 0.0199
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0066 0.0215
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0002 0.0002
Onchocerca volvulus 0.0017 0.0053 0.0165
Leishmania major cathepsin L-like protease 0.0063 0.0358 0.101
Trypanosoma brucei heat shock protein, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0039 0.0199 0.0197
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0168
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.037 0.037
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0039 0.0199 0.0647
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0279 0.0749
Echinococcus multilocularis acetylcholinesterase 0.0134 0.0822 0.0822
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0023 0.0092 0.0298
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0053 0.0053
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.037 0.037
Onchocerca volvulus 0.0023 0.0092 0.0293
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0358 0.1164
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0039 0.0199 0.0199
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0338 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Brugia malayi hypothetical protein 0.0031 0.0145 0.0145
Schistosoma mansoni protein tyrosine phosphatase 0.0039 0.0199 0.0199
Giardia lamblia Pms1-like protein 0.0027 0.0118 0.2445
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Onchocerca volvulus 0.0061 0.0342 0.1097
Echinococcus multilocularis cysteine protease 0.0017 0.0053 0.0053
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0002 0.0002
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0002 0.0002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Brugia malayi Protein-tyrosine phosphatase 0.0039 0.0199 0.0199
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.037 0.037
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0145 0.0145
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0002 0.0002
Schistosoma mansoni heat shock protein 0.0027 0.0118 0.0118
Echinococcus granulosus RUN 0.0039 0.0202 0.0202
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0178 0.0574
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0118 0.0962
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0117
Brugia malayi beta-lactamase family protein 0.0036 0.0178 0.0178
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0202 0.0202
Schistosoma mansoni rab6-interacting 0.0039 0.0202 0.0202
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0039 0.0199 0.0199
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0167 0.1039 0.8562
Schistosoma mansoni thyroid hormone receptor 0.0065 0.037 0.037
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0322 0.1048
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0338 0.2778
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0902 0.0902
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0178 0.0574
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0178 0.0574
Echinococcus granulosus acetylcholinesterase 0.0134 0.0822 0.0822
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0279 0.0901
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0145 0.0145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0118 0.038
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0039 0.0199 0.0197
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0118 0.0384
Toxoplasma gondii ABC1 family protein 0.0036 0.0178 0.1453
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0039 0.0199 0.0199
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0053 0.2605
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0477 0.3076 0.3076
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0118 0.038
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0118 0.038
Brugia malayi Cathepsin L-like precursor 0.0017 0.0053 0.0053
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0118 0.0381
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Brugia malayi nuclear receptor RXR 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0184 0.5534
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0034 0.0169 0.0168
Schistosoma mansoni dep domain containing protein 0.0009 0.0002 0.0002
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0053 0.0053
Onchocerca volvulus 4.1 G protein, putative homolog 0.0039 0.0199 0.0637
Brugia malayi beta-lactamase family protein 0.0036 0.0178 0.0178
Leishmania major hypothetical protein, conserved 0.0027 0.0118 0.0217
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0002 0.0002
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0027 0.0118 1
Brugia malayi follicle stimulating hormone receptor 0.0229 0.1448 0.1448
Giardia lamblia Protein tyrosine phosphatase 0.0039 0.0199 0.6232
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0053 0.0053
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0039 0.0199 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0039 0.0199 0.0199
Brugia malayi hypothetical protein 0.0034 0.0169 0.0169
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0039 0.0199 0.0199
Brugia malayi DIX domain containing protein 0.0009 0.0002 0.0002
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0202 0.6392
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Loa Loa (eye worm) hypothetical protein 0.0036 0.0178 0.0176
Schistosoma mansoni dishevelled 0.0009 0.0002 0.0002
Schistosoma mansoni neuroligin 3 (S09 family) 0.0023 0.0092 0.0092
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0053 0.2605
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0338 0.0338
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Onchocerca volvulus 0.0039 0.0199 0.0637
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0169 0.0169
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0118 0.1916
Onchocerca volvulus 0.0036 0.0178 0.0568
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0338 1
Loa Loa (eye worm) cysteine protease 0.0017 0.0053 0.0051
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.011 0.0666 0.0666
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0118 0.1916
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0279 0.0749
Schistosoma mansoni lamin 0.0027 0.0119 0.0119
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0053 0.0165
Schistosoma mansoni hypothetical protein 0.0054 0.0297 0.0297
Brugia malayi Cathepsin L-like precursor 0.0011 0.0017 0.0017
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0477 0.3076 1
Entamoeba histolytica hypothetical protein 0.0036 0.0178 0.8775
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.037 0.037
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0031 0.0145 0.0143
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0066 0.0044
Loa Loa (eye worm) hypothetical protein 0.0065 0.037 0.0369
Loa Loa (eye worm) acetyltransferase 0.0146 0.0902 0.0901
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Onchocerca volvulus 0.0017 0.0053 0.0165
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0118 0.0381
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0039 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Onchocerca volvulus 0.0027 0.0119 0.0379
Entamoeba histolytica hypothetical protein 0.0036 0.0178 0.8775
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0358 0.1164
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0027
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0038 0.0036
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0118 0.0376
Echinococcus granulosus acetylcholinesterase 0.0134 0.0822 0.0822
Toxoplasma gondii heat shock protein 90, putative 0.0027 0.0118 0.0962
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0039 0.0199 0.0197
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0184 0.0594
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0145 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0118 0.3461
Brugia malayi steroid hormone receptor 0.0065 0.037 0.037
Brugia malayi ecdysone receptor 0.0031 0.0145 0.0145
Echinococcus multilocularis heat shock protein 0.0027 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0036 0.0178 0.0178
Onchocerca volvulus 0.0039 0.0199 0.0637
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0226 0.185
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0039 0.0199 0.0199
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0167 0.1039 0.3262
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0118 0.0381
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0039 0.0199 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0279 0.0901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0226 0.6611
Onchocerca volvulus 0.0023 0.0092 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.037 0.0369
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0039 0.0199 0.0199
Brugia malayi Doublecortin family protein 0.0039 0.0202 0.0202
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0279 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0017 0.0054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0202 0.0202
Loa Loa (eye worm) cytochrome P450 family protein 0.0045 0.0238 0.0236
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0028 0.0028
Trypanosoma brucei heat shock protein 90, putative 0.0027 0.0118 0.0384
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0066 0.0213
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.153 1 1
Loa Loa (eye worm) ctsf protein 0.0017 0.0053 0.0051
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0118 0.0381
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0279 0.0279
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0226 0.185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Loa Loa (eye worm) DR-78 0.0031 0.0145 0.0143
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0169 0.0169
Loa Loa (eye worm) hypothetical protein 0.0039 0.0199 0.0197
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0184 0.0184
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0039 0.0199 0.0199
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0178 0.0574
Leishmania major heat shock protein 83-1 0.0027 0.0118 0.0217
Echinococcus multilocularis hypothetical protein 0.0039 0.0199 0.0199
Brugia malayi Carboxylesterase family protein 0.0023 0.0092 0.0092
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0178 0.0574
Onchocerca volvulus 0.0023 0.0092 0.0293
Brugia malayi Cytochrome P450 family protein 0.0045 0.0238 0.0238
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0119 0.0119
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0338 0.0338
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0118 0.5843
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0053 0.0165
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0118 0.0384
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0145 0.0145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0178 0.0178
Echinococcus multilocularis RUN 0.0039 0.0202 0.0202
Echinococcus multilocularis musashi 0.0027 0.0119 0.0119
Schistosoma mansoni polycystin 1-related 0.0039 0.0202 0.0202
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0338 0.0338
Brugia malayi hypothetical protein 0.0039 0.0202 0.0202
Plasmodium falciparum heat shock protein 90 0.0027 0.0118 0.5843
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0053 0.017
Leishmania major developmentally regulated phosphoprotein-like protein 0.0477 0.3076 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0184 0.0182
Loa Loa (eye worm) hypothetical protein 0.0023 0.0092 0.0091
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0002 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.037 0.0369
Brugia malayi MAP kinase sur-1 0.0051 0.0279 0.0279
Brugia malayi hypothetical protein 0.0009 0.0002 0.0002
Echinococcus granulosus lamin dm0 0.0027 0.0119 0.0119

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 115 mg kg-1 Antiviral activity against Forest virus (SFV) ChEMBL. 2999405
ED50 (functional) = 330 mg kg-1 Effective dose administered perorally againist Forest virus infected mice ChEMBL. 2999405
IFN (functional) >= 2000 ml Evaluation for serum interferon response from a single 800 mg/kg intraperitoneal administration in vesicular stomatitis virus on L292 cells. ChEMBL. 2999405
Protection index (functional) = 0.54 Intraperitoneal administration against herpes simplex virus type-1 (HSV-1) infected mice ChEMBL. 2999405

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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