Detailed information for compound 81980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 555.578 | Formula: C31H29N3O7
  • H donors: 2 H acceptors: 3 LogP: 2.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCc1ccc2c(c1)c1c3C(=O)NCc3c3c4c1n2C1C[C@]([C@](O1)(n4c1c3cc(cc1)COC)C)(O)C(=O)OC
  • InChi: 1S/C31H29N3O7/c1-30-31(37,29(36)40-4)11-22(41-30)33-20-7-5-15(13-38-2)9-17(20)24-25-19(12-32-28(25)35)23-18-10-16(14-39-3)6-8-21(18)34(30)27(23)26(24)33/h5-10,22,37H,11-14H2,1-4H3,(H,32,35)/t22?,30-,31-/m0/s1
  • InChiKey: MDAFGVXLBFQEJH-XCFOVOSNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neurotrophic tyrosine kinase, receptor, type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0163 0.1813 0.6566
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0014 0.009 0.0247
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0009 0.0037 0.01
Echinococcus multilocularis sh3 containing grb2 protein 3 0.001 0.004 0.004
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1401 0.2987
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Giardia lamblia DINP protein human, muc B family 0.0021 0.0167 0.1496
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Leishmania major DNA polymerase kappa, putative 0.0006 0.0003 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0304 0.0648
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0112 0.0302
Schistosoma mansoni importin beta-1 0.0031 0.0284 0.0606
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0003 0.0009
Giardia lamblia Kinase, PLK 0.0101 0.1097 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.067 0.067
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4692 1
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0014 0.009 0.0247
Echinococcus granulosus sh3 containing grb2 protein 3 0.001 0.004 0.0086
Brugia malayi TAR-binding protein 0.0127 0.1401 0.4077
Echinococcus granulosus tar DNA binding protein 0.0127 0.1401 0.2987
Loa Loa (eye worm) hypothetical protein 0.0159 0.1766 0.4753
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0604 0.1287
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0247
Mycobacterium ulcerans hypothetical protein 0.0169 0.1885 0.5481
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0245 0.276 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1687 0.4631
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0452 0.124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Leishmania major DNA polymerase eta, putative 0.0048 0.048 0.1318
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0304 0.0648
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0112 0.0112
Loa Loa (eye worm) BAR domain-containing protein 0.001 0.004 0.0109
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0522 0.1405
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0037 0.0079
Schistosoma mansoni membrane traffic protein 0.001 0.004 0.0086
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0126 0.0444
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0167 0.0356
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0014 0.009 0.0247
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0167 0.0356
Trypanosoma brucei unspecified product 0.0014 0.0093 0.0256
Trypanosoma brucei SH3 domain protein, conserved 0.001 0.004 0.0111
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0126 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0054 0.0115
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.3175
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.001 0.0022
Brugia malayi mbt repeat family protein 0.0051 0.0522 0.1519
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0452 0.124
Plasmodium vivax peptide deformylase, putative 0.0245 0.276 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0054 0.0156
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0008 0.0027 0.0063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0462 0.1244
Toxoplasma gondii hypothetical protein 0.0056 0.0579 0.2087
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0217 0.0617
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.1401 0.3771
Brugia malayi Abl-interactor 1 0.001 0.004 0.0118
Schistosoma mansoni serine/threonine kinase 0.0009 0.0037 0.0079
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0007 0.0007 0.0019
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Echinococcus granulosus protein kinase C gamma type 0.0011 0.0052 0.011
Echinococcus multilocularis Src y 3 domain 0.001 0.004 0.004
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.009 0.0247
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0017 0.0122 0.0122
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0284 0.1019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0304 0.0648
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0054 0.0145
Treponema pallidum polypeptide deformylase (def) 0.0245 0.276 1
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0014 0.009 0.0247
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0054 0.0156
Entamoeba histolytica serine/threonine protein kinase, putative 0.0101 0.1097 1
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0536 0.1933
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0202 0.043
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0054 0.0115
Echinococcus multilocularis serine:threonine protein kinase 38 0.0009 0.0037 0.0037
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0462 0.0985
Schistosoma mansoni coup transcription factor 0.0011 0.0054 0.0115
Brugia malayi Latrophilin receptor protein 2 0.0064 0.067 0.195
Brugia malayi Pip kinase protein 2 0.0173 0.1929 0.5612
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0112 0.0302
Echinococcus multilocularis muscleblind protein 0.0159 0.1766 0.1766
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0163 0.1813 0.6566
Loa Loa (eye worm) hypothetical protein 0.0173 0.1929 0.5191
Echinococcus multilocularis protein kinase c epsilon type 0.0017 0.0122 0.0122
Loa Loa (eye worm) Smad1 0.0009 0.0031 0.0082
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0126 0.0126
Echinococcus multilocularis rho guanine nucleotide exchange factor 16 0.001 0.004 0.004
Onchocerca volvulus 0.0252 0.2849 1
Brugia malayi polk-prov protein 0.0006 0.0003 0.0009
Brugia malayi isocitrate dehydrogenase 0.0017 0.0126 0.0366
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0462 0.1344
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0093 0.0256
Loa Loa (eye worm) MBCTL1 0.0058 0.0604 0.1625
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Toxoplasma gondii hypothetical protein 0.0052 0.0528 0.1905
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0202 0.2264 0.4825
Echinococcus granulosus growth factor receptor bound protein 2 0.001 0.004 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0462 0.0462
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.1813 0.6566
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0126 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0462 0.0985
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0122 0.026
Loa Loa (eye worm) hypothetical protein 0.0057 0.0586 0.1577
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0007 0.0015 0.0031
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0604 0.1287
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0009 0.0037 0.01
Schistosoma mansoni hypothetical protein 0.0064 0.067 0.1429
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0264 0.071
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1401 0.2987
Brugia malayi hypothetical protein 0.0036 0.0348 0.1014
Loa Loa (eye worm) variant SH3 domain-containing protein 0.001 0.004 0.0109
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.048 0.1318
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0339 0.3847 0.8199
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0112 0.0239
Brugia malayi CXXC zinc finger family protein 0.0029 0.0264 0.0768
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.3643 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0054 0.0115
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0054 0.0115
Echinococcus multilocularis protein kinase c iota type 0.0098 0.1067 0.1067
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0122 0.026
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0096 0.104 0.28
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.009 0.0247
Schistosoma mansoni serine/threonine protein kinase 0.0007 0.001 0.0022
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0522 0.1112
Leishmania major hypothetical protein, conserved 0.0016 0.0112 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0579 0.2087
Brugia malayi MH2 domain containing protein 0.0009 0.0031 0.0089
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.048 0.1397
Entamoeba histolytica BAR/SH3 domain containing protein 0.001 0.004 0.0369
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1097 0.3012
Schistosoma mansoni tyrosine kinase 0.0014 0.0095 0.0202
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.067 0.1804
Brugia malayi serine/threonine-protein kinase plk-2 0.0101 0.1097 0.3193
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0054 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0054 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0014 0.009 0.0247
Loa Loa (eye worm) TKL/MLK/MLK protein kinase 0.001 0.0051 0.0136
Loa Loa (eye worm) hypothetical protein 0.0053 0.0538 0.1448
Schistosoma mansoni smad1 5 8 and 0.0009 0.0031 0.0065
Schistosoma mansoni hypothetical protein 0.0057 0.0586 0.1249
Echinococcus granulosus dna polymerase kappa 0.0021 0.0167 0.0356
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.009 0.0247
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1401 0.2987
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.009 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Brugia malayi jmjC domain containing protein 0.0016 0.0112 0.0326
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0031 0.0031
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0126 0.0345
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0112 0.0112
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0315
Loa Loa (eye worm) FYVE zinc finger family protein 0.0014 0.009 0.0242
Loa Loa (eye worm) abl-interactor 1 0.001 0.004 0.0109
Entamoeba histolytica protein kinase, putative 0.0009 0.0037 0.0338
Loa Loa (eye worm) hypothetical protein 0.0051 0.0522 0.1405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Loa Loa (eye worm) glutaminase 2 0.0303 0.3437 0.9249
Brugia malayi RNA, U transporter 1 0.0087 0.0938 0.273
Echinococcus multilocularis protein of unknown function DUF2013 0.001 0.004 0.004
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0007 0.001 0.0022
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0302
Echinococcus multilocularis tumor protein p63 0.0359 0.4086 0.4086
Schistosoma mansoni hypothetical protein 0.0412 0.4692 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0604 0.0604
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0173 0.1929 0.4111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0462 0.0462
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0101 0.1097 0.2953
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.067 0.1429
Brugia malayi Protein kinase c protein 2 0.0008 0.0025 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0054 0.0156
Echinococcus granulosus dna polymerase eta 0.0048 0.048 0.1024
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0633 0.1704
Entamoeba histolytica phosphoinositide kinase, putative 0.0014 0.009 0.082
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0302
Echinococcus granulosus RIMS binding protein 2 0.001 0.004 0.0086
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0112 0.0239
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0014 0.009 0.0192
Leishmania major paraflagellar rod protein-like protein 0.001 0.004 0.0111
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.1813 0.5272
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Brugia malayi Protein kinase domain containing protein 0.0009 0.0037 0.0108
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.067 0.195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0054 0.0115
Schistosoma mansoni hypothetical protein 0.0182 0.2034 0.4335
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Echinococcus granulosus smad 0.0009 0.0031 0.0065
Loa Loa (eye worm) hypothetical protein 0.0052 0.0536 0.1443
Schistosoma mansoni serine/threonine protein kinase 0.001 0.004 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Loa Loa (eye worm) hypothetical protein 0.0064 0.067 0.1804
Onchocerca volvulus 0.0057 0.0586 0.2057
Plasmodium vivax SET domain protein, putative 0.0032 0.0304 0.1091
Echinococcus multilocularis geminin 0.0182 0.2034 0.2034
Echinococcus multilocularis peptidase Clp (S14 family) 0.0107 0.1164 0.1164
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0304 0.0648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0054 0.0145
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0304 0.0304
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0054 0.0115
Echinococcus multilocularis Smad4 0.0009 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0058 0.0604 0.1625
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0054 0.0145
Leishmania major hypothetical protein, conserved 0.001 0.004 0.0111
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0167 0.0156
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.3175
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0014 0.009 0.0242
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.009 0.0192
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0604 0.1757
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0614 0.1309
Trypanosoma brucei polo-like protein kinase 0.0101 0.1097 0.3012
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0633 0.135
Echinococcus granulosus protein kinase c iota type 0.0098 0.1067 0.2275
Echinococcus multilocularis NCK adaptor protein 0.001 0.004 0.004
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0538 0.1146
Echinococcus multilocularis snurportin 1 0.0327 0.3716 0.3716
Brugia malayi Importin beta-1 subunit 0.0031 0.0284 0.0827
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0054 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.004 0.0111
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0167 0.0458
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0112 0.0308
Brugia malayi Smad1 0.0009 0.0031 0.0089
Onchocerca volvulus 0.001 0.004 0.0142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0054 0.0156
Schistosoma mansoni hypothetical protein 0.0138 0.153 0.3261
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0112 0.0308
Schistosoma mansoni protein kinase C 0.0007 0.0015 0.0031
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0107 0.1164 0.3942
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.153 0.4451
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0167 0.0486
Loa Loa (eye worm) hypothetical protein 0.0159 0.1766 0.4753
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0009 0.0037 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0304 0.0648
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.2496 0.6716
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0009 0.0037 0.0037
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0167 0.1521
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0054 0.0156
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0112 0.0302
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0014 0.009 0.0247
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0054 0.0115
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Schistosoma mansoni nebulin 0.001 0.004 0.0086
Loa Loa (eye worm) variant SH3 domain-containing protein 0.001 0.004 0.0109
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0054 0.0054
Echinococcus granulosus geminin 0.0182 0.2034 0.4335
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0793
Schistosoma mansoni hypothetical protein 0.0024 0.0202 0.043
Trypanosoma cruzi Peptide deformylase 2, putative 0.0093 0.101 0.2772
Echinococcus multilocularis Cbl interacting protein of 85 kDa 0.001 0.004 0.004
Toxoplasma gondii AGC kinase 0.0009 0.0037 0.0123
Schistosoma mansoni kinase 0.0052 0.0526 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0093 0.0256
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0003 0.0009
Schistosoma mansoni glutaminase 0.0303 0.3437 0.7326
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0163 0.1813 0.1813
Echinococcus multilocularis serine threonine protein kinase 0.0011 0.0052 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.082
Brugia malayi Probable ClpP-like protease 0.0163 0.1813 0.5276
Schistosoma mansoni DNA polymerase eta 0.0048 0.048 0.1024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0054 0.0156
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0037 0.0037
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0009 0.0037 0.01
Schistosoma mansoni atypical protein kinase C 0.0104 0.1138 0.2425
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0284 0.078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0304 0.0304
Schistosoma mansoni Smad4 0.0009 0.0031 0.0065
Echinococcus granulosus serine:threonine protein kinase N2 0.0009 0.0037 0.0079
Brugia malayi protein kinase C3,putative 0.009 0.097 0.2822
Brugia malayi jmjC domain containing protein 0.0061 0.0633 0.1843
Echinococcus multilocularis RIMS binding protein 2 0.001 0.004 0.004
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0054 0.0115
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0283 0.0603
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0202 0.2264 0.2264
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0284 0.078
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0054 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Loa Loa (eye worm) histone methyltransferase 0.001 0.0046 0.0125
Onchocerca volvulus 0.0007 0.001 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Schistosoma mansoni hypothetical protein 0.0064 0.067 0.1429
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0101 0.1097 0.2339
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0014 0.009 0.0247
Echinococcus multilocularis raf serine:threonine protein kinase 0.0011 0.0054 0.0054
Brugia malayi Hr1 repeat family protein 0.0009 0.0037 0.0108
Echinococcus granulosus importin subunit beta 1 0.0031 0.0284 0.0606
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0167 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0348 0.0743
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0348 0.0743
Echinococcus multilocularis tar DNA binding protein 0.0127 0.1401 0.1401
Schistosoma mansoni smad1 5 8 and 0.0009 0.0031 0.0065
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0014 0.009 0.0247
Echinococcus granulosus GPCR family 2 0.0064 0.067 0.1429
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.067 0.067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0054 0.0145
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0014 0.009 0.0247
Echinococcus granulosus peptidase Clp S14 family 0.0107 0.1164 0.2482
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1401 0.2987
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0247
Trypanosoma brucei Peptide deformylase 2 0.0093 0.101 0.2772
Loa Loa (eye worm) TAR-binding protein 0.0127 0.1401 0.3771
Schistosoma mansoni hematopoietic lineage cell specific protein 0.001 0.004 0.0086
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.1412 0.38
Echinococcus multilocularis inhibitor of apoptosis protein 0.0057 0.0586 0.0586
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0007 0.001 0.0028
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0536 0.1472
Brugia malayi hypothetical protein 0.001 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.0048 0.048 0.1292
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0014 0.009 0.0192
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0007 0.001 0.0029
Schistosoma mansoni cpg binding protein 0.0031 0.0283 0.0603
Onchocerca volvulus 0.0029 0.0264 0.0926
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0054 0.0115
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0054 0.0189
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0167 0.0356
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.001 0.004 0.0086
Onchocerca volvulus 0.0032 0.0304 0.1066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0329 0.3736 0.7962
Trypanosoma brucei rac serine-threonine kinase, putative 0.0009 0.0037 0.0102
Loa Loa (eye worm) pip kinase 1 0.0014 0.009 0.0242
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0026 0.0026
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Trypanosoma brucei paraflagellar rod protein 5, putative 0.001 0.004 0.0111
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0003 0.0009
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0112 0.0239
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.067 0.1429
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.009 0.0315
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0167 0.0471
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0054 0.0115
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0536 0.1933
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0321 0.3643 1
Leishmania major polypeptide deformylase-like protein, putative 0.0093 0.101 0.2772
Entamoeba histolytica SH3 domain protein 0.001 0.004 0.0369
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0014 0.009 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0604 0.0604
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0026 0.0056
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0054 0.0115
Schistosoma mansoni sh3-containing grb2-like protein 3 (endophilin III) 0.001 0.004 0.0086
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0046 0.0046
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0217 0.0617
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.004 0.0086
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0057 0.0586 0.1249
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0126 0.0345
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0126 0.0444
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0247
Schistosoma mansoni rhogef and pleckstrin domain protein 0.001 0.004 0.0086
Echinococcus granulosus muscleblind protein 0.0159 0.1766 0.3764
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0086
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0054 0.0115
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.1401 0.4077
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0321 0.3643 1
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0086
Loa Loa (eye worm) glutaminase 0.0303 0.3437 0.9249
Leishmania major peroxin 13, putative;with=GeneDB:Tb927.10.14720 0.001 0.004 0.0111
Onchocerca volvulus 0.0007 0.0015 0.0051
Entamoeba histolytica protein kinase, putative 0.0009 0.0037 0.0338
Schistosoma mansoni cpg binding protein 0.0029 0.0264 0.0562
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Echinococcus granulosus tumor protein p63 0.0359 0.4086 0.8709
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0126 0.0338
Chlamydia trachomatis peptide deformylase 0.0245 0.276 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0652 0.139
Schistosoma mansoni unc-13 (munc13) 0.0007 0.0015 0.0031
Onchocerca volvulus 0.001 0.004 0.0142
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0054 0.0115
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0126 0.0345
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.2271 0.6111
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0054 0.0145
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0054 0.0156
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0126 0.0126
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Leishmania major DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0054 0.0054
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0112 0.0395
Entamoeba histolytica hypothetical protein 0.001 0.004 0.0369
Brugia malayi glutaminase DH11.1 0.0303 0.3437 1
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0037 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0054 0.0054
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0101 0.1097 0.1097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0026 0.0056
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0057 0.0586 0.1705
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0037 0.0079
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0327 0.3716 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Onchocerca volvulus 0.001 0.004 0.0142
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0614 0.1309
Loa Loa (eye worm) hypothetical protein 0.0138 0.153 0.4117
Trichomonas vaginalis set domain proteins, putative 0.0252 0.2849 0.8287
Plasmodium vivax importin-beta 2, putative 0.0031 0.0284 0.1019
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0054 0.0189
Leishmania major DNA damage repair protein, putative 0.0006 0.0003 0.0009
Brugia malayi Protein kinase domain containing protein 0.0007 0.001 0.003
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0126 0.0366
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0163 0.1813 0.566
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0054 0.0054
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0173 0.1929 0.4111
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0031 0.0065
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0126 0.0268
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0026 0.0026
Echinococcus granulosus phd:f box containing protein 0.0016 0.0112 0.0239
Echinococcus granulosus NDR protein kinase 0.0009 0.0037 0.0079
Loa Loa (eye worm) hypothetical protein 0.0006 0.0003 0.0009
Brugia malayi nuclear receptor NHR-88 0.0011 0.0054 0.0156
Echinococcus multilocularis intersectin 2 0.0011 0.0055 0.0055
Echinococcus granulosus Protein kinase C brain isozyme 0.0017 0.0122 0.026
Brugia malayi Protein kinase domain containing protein 0.0007 0.001 0.0029
Plasmodium falciparum peptide deformylase 0.0245 0.276 1
Schistosoma mansoni hypothetical protein 0.0182 0.2034 0.4335
Loa Loa (eye worm) variant SH3 domain-containing protein 0.001 0.004 0.0109
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0112 0.0395
Brugia malayi jmjC domain containing protein 0.0016 0.0112 0.0326
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0054 0.0054
Loa Loa (eye worm) RNA binding protein 0.0127 0.1401 0.3771
Brugia malayi hypothetical protein 0.0034 0.0321 0.0934
Echinococcus granulosus protein kinase C and casein kinase substrate in 0.001 0.004 0.0086
Entamoeba histolytica protein kinase, putative 0.001 0.004 0.0369
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0339 0.3847 0.3847
Schistosoma mansoni smad 0.0009 0.0031 0.0065
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0014 0.009 0.0247
Loa Loa (eye worm) hypothetical protein 0.0032 0.0304 0.0818
Brugia malayi hypothetical protein 0.0052 0.0536 0.156
Leishmania major hypothetical protein, conserved 0.0052 0.0536 0.1472
Echinococcus multilocularis protein kinase C and casein kinase substrate in 0.001 0.004 0.004
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0101 0.1097 0.3012
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0536 0.1472
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0522 0.1112
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0614 0.0614
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0054 0.0115
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0522 0.0522
Loa Loa (eye worm) AGC/NDR protein kinase 0.0009 0.0037 0.01
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.1412 0.38
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0003 0.0009
Loa Loa (eye worm) AGC/PKN protein kinase 0.0009 0.0037 0.01
Entamoeba histolytica hypothetical protein 0.0025 0.0217 0.1979
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0031 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0462 0.0985
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0054 0.0115
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0167 0.0477
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0452 0.124
Plasmodium vivax JmjC domain containing protein 0.0016 0.0112 0.0395
Schistosoma mansoni peptidase Clp (S14 family) 0.0163 0.1813 0.3865
Schistosoma mansoni inhibitor of apoptosis protein 0.0057 0.0586 0.1249
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0126 0.0345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0462 0.0985
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Trypanosoma brucei unspecified product 0.0021 0.0167 0.0458
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0054 0.0115
Echinococcus granulosus abl interactor 2 0.001 0.004 0.0086
Echinococcus granulosus snurportin 1 0.0327 0.3716 0.792
Echinococcus multilocularis muscleblind protein 1 0.0159 0.1766 0.1766
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.004 0.004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0026 0.0056
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1885 0.668
Echinococcus granulosus protein of unknown function DUF2013 0.001 0.004 0.0086
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Brugia malayi C1-like domain containing protein 0.0007 0.001 0.0029
Echinococcus multilocularis smad 0.0009 0.0031 0.0031
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Loa Loa (eye worm) hypothetical protein 0.0057 0.0586 0.1577
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0037 0.0037
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0284 0.0284
Trichomonas vaginalis glutaminase, putative 0.0303 0.3437 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0009 0.0037 0.0079
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.2271 0.6607
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.1813 0.5272
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0112 0.0239
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0009 0.0037 0.0037
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0131 0.0131
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.009 0.0315
Brugia malayi Protein kinase domain containing protein 0.0009 0.0037 0.0108
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0167 0.0477
Echinococcus granulosus LIM and SH3 domain protein 1 0.001 0.004 0.0086
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0046 0.0099
Brugia malayi RNA binding protein 0.0127 0.1401 0.4077
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0167 0.0458
Echinococcus granulosus intersectin 2 0.0011 0.0055 0.0117
Onchocerca volvulus Rho guanine nucleotide exchange factor 3 homolog 0.001 0.004 0.0142
Brugia malayi nuclear hormone receptor 0.0011 0.0054 0.0156
Onchocerca volvulus Serine\/threonine kinase homolog 0.0101 0.1097 0.3851
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0003 0.0009
Brugia malayi steroid hormone receptor 0.0011 0.0054 0.0156
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0202 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1401 0.2987
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Brugia malayi hypothetical protein 0.001 0.004 0.0118
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0522 0.1112
Schistosoma mansoni hypothetical protein 0.0327 0.3716 0.792
Brugia malayi jmjC domain containing protein 0.0016 0.0112 0.0326
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0112 0.0112
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0031 0.0065
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0522 0.1832
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0126 0.0444
Toxoplasma gondii hypothetical protein 0.0245 0.276 1
Echinococcus multilocularis cpg binding protein 0.0031 0.0283 0.0283
Mycobacterium ulcerans glutaminase 0.0303 0.3437 1
Brugia malayi Muscleblind-like protein 0.0159 0.1766 0.5139
Brugia malayi MH2 domain containing protein 0.0009 0.0031 0.0089
Onchocerca volvulus 0.0011 0.0054 0.0189
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0003 0.0007
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0054 0.0156
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0522 0.1112
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0014 0.009 0.0192
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0522 0.1112
Schistosoma mansoni smad1 5 8 and 0.0009 0.0031 0.0065
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0003 0.0009
Schistosoma mansoni hypothetical protein 0.0311 0.3531 0.7525
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0054 0.0156
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0522 0.0522
Brugia malayi MH1 domain containing protein 0.0009 0.0031 0.0089
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0163 0.1813 0.3865
Schistosoma mansoni hypothetical protein 0.0064 0.067 0.1429
Schistosoma mansoni hypothetical protein 0.0036 0.0348 0.0743
Echinococcus granulosus protein kinase c epsilon type 0.0017 0.0122 0.026
Loa Loa (eye worm) hypothetical protein 0.0009 0.0037 0.01
Brugia malayi Pre-SET motif family protein 0.0032 0.0304 0.0884
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0017 0.0122 0.0329
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0054 0.0145
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0304 0.1091
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0112 0.0239
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0112 0.0239
Onchocerca volvulus 0.001 0.004 0.0142
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.1813 0.6566
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0054 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.004 0.0111
Plasmodium vivax hypothetical protein, conserved 0.0014 0.009 0.0315
Entamoeba histolytica protein kinase, putative 0.0009 0.0037 0.0338
Trichomonas vaginalis conserved hypothetical protein 0.001 0.004 0.0102
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0604 0.1287
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0536 0.1933
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0054 0.0115
Echinococcus granulosus inhibitor of apoptosis protein 0.0057 0.0586 0.1249
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0009 0.0037 0.0079
Brugia malayi p70 ribosomal S6 kinase beta 0.0009 0.0037 0.0108
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0107 0.1164 0.2685
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.048 0.1318
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0057 0.0586 0.0586
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0014 0.009 0.0192
Loa Loa (eye worm) hypothetical protein 0.0202 0.2271 0.6111
Loa Loa (eye worm) AGC/AKT protein kinase 0.0009 0.0037 0.01
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0054 0.0156
Brugia malayi mbt repeat family protein 0.0051 0.0522 0.1519
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0057 0.0586 0.1705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0054 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0122 0.026
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0217 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0054 0.0156
Leishmania major hypothetical protein, conserved 0.001 0.004 0.0111
Echinococcus granulosus raf serine:threonine protein kinase 0.0011 0.0054 0.0115
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0003 0.0009
Brugia malayi ecdysteroid receptor 0.0011 0.0054 0.0156
Brugia malayi Pre-SET motif family protein 0.0222 0.2496 0.7261
Brugia malayi MH1 domain containing protein 0.0009 0.0031 0.0089
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0126 0.0345
Entamoeba histolytica hypothetical protein 0.001 0.004 0.0369
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0003 0.0009
Echinococcus granulosus Src y 3 domain 0.001 0.004 0.0086
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0031 0.0065
Echinococcus multilocularis dna polymerase eta 0.0048 0.048 0.048
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0167 0.0167
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0348 0.0348
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0054 0.0145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0054 0.0115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0126 0.0444
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0037 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0054 0.0054
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0009 0.0037 0.0037
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0093 0.101 0.2772
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Plasmodium falciparum importin beta, putative 0.0031 0.0284 0.1019
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0007 0.001 0.0027
Trypanosoma cruzi polo-like protein kinase, putative 0.0101 0.1097 0.3012
Schistosoma mansoni hypothetical protein 0.001 0.004 0.0086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0284 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0003 0.0009
Echinococcus multilocularis endophilin A3 0.001 0.004 0.004
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Trypanosoma brucei unspecified product 0.0014 0.0093 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0054 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0093 0.0256
Leishmania major importin beta-1 subunit, putative 0.0025 0.0217 0.0596
Onchocerca volvulus 0.0173 0.1929 0.677
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0511 0.1473
Echinococcus multilocularis abl interactor 2 0.001 0.004 0.004
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.3175
Loa Loa (eye worm) variant SH3 domain-containing protein 0.001 0.004 0.0109
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0633 0.135
Brugia malayi protein kinase C II. 0.0017 0.0122 0.0355
Echinococcus granulosus cpg binding protein 0.0031 0.0283 0.0603
Giardia lamblia Hypothetical protein 0.0014 0.009 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0054 0.0156
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4692 0.4692
Schistosoma mansoni growth factor receptor-bound protein 0.001 0.004 0.0086
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0577 0.208
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0014 0.009 0.0315
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0145
Onchocerca volvulus 0.0051 0.0522 0.1832
Echinococcus multilocularis unc 13 (munc13) 0.0007 0.0015 0.0015
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0045 0.0131
Loa Loa (eye worm) hypothetical protein 0.0016 0.0112 0.0302
Brugia malayi Protein kinase domain containing protein 0.0009 0.0037 0.0108
Trypanosoma brucei Polypeptide deformylase 1 0.0093 0.101 0.2772
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0167 0.0449
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0614 0.0614
Loa Loa (eye worm) hypothetical protein 0.001 0.004 0.0109
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0057 0.0586 0.1249
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0007 0.0015 0.0015
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0054 0.0189
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0112 0.0239
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0131 0.028
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0217 0.0596
Trichomonas vaginalis p67phox protein, putative 0.001 0.004 0.0102
Mycobacterium ulcerans peptide deformylase 0.0245 0.276 0.8029
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0126 0.0126
Loa Loa (eye worm) variant SH3 domain-containing protein 0.001 0.004 0.0109
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0112 0.0112
Schistosoma mansoni serine/threonine protein kinase 0.0101 0.1097 0.2339
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0093 0.101 0.2772
Trichomonas vaginalis CAMK family protein kinase 0.0101 0.1097 0.3182
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0112 0.0308
Loa Loa (eye worm) hypothetical protein 0.0163 0.1813 0.488
Entamoeba histolytica protein kinase, putative 0.0009 0.0037 0.0338
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0112 0.0239
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0633 0.135
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0317 0.0869
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0247
Brugia malayi jmjC domain containing protein 0.0016 0.0112 0.0326
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0579 0.2087
Echinococcus granulosus rho guanine nucleotide exchange factor 16 0.001 0.004 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0511 0.1473
Echinococcus granulosus Cbl interacting protein of 85 kDa 0.001 0.004 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0011 0.0054 0.0115
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0566 0.1553
Schistosoma mansoni protein kinase C mu 0.0007 0.001 0.0022
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0167 0.0471
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0112 0.0395
Echinococcus multilocularis GPCR, family 2 0.0064 0.067 0.067
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0014 0.009 0.0192
Onchocerca volvulus Deterin homolog 0.0057 0.0586 0.2057
Schistosoma mansoni unc-13 (munc13) 0.0009 0.0038 0.0082
Entamoeba histolytica hypothetical protein 0.0036 0.0348 0.3175
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0003 0.0009
Onchocerca volvulus 0.0053 0.0538 0.1888
Schistosoma mansoni dynamin-associated protein 0.001 0.004 0.0086
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1687 0.4631
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0245 0.276 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0054 0.0054
Brugia malayi MH2 domain containing protein 0.0128 0.1412 0.4109
Brugia malayi jmjC domain containing protein 0.0059 0.0614 0.1787
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0462 0.0985
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0163 0.1813 0.566
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0054 0.0156
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0536 0.1472
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0536 0.1933
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0107 0.1164 0.3942
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0003 0.0009
Echinococcus multilocularis LIM and SH3 domain protein 1 0.001 0.004 0.004
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0173 0.1929 0.1929
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0007 0.001 0.001
Brugia malayi Variant SH3 domain containing protein 0.001 0.0051 0.0147
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0014 0.009 0.0262
Leishmania major DNA polymerase eta, putative 0.0033 0.0317 0.0869
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0014 0.009 0.0315
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0007 0.0015 0.0039
Schistosoma mansoni hypothetical protein 0.0064 0.067 0.1429
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0031 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0167 0.0458
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0014 0.009 0.0247
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0009 0.0037 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Echinococcus granulosus Smad4 0.0009 0.0031 0.0065
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0452 0.124
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1687 0.4631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.2271 0.6607
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0167 0.0167
Echinococcus granulosus unc 13 munc13 0.0007 0.0015 0.0031
Leishmania major mitochondrial DNA polymerase beta 0.0321 0.3643 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0317 0.1137
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0245 0.276 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0167 0.0458
Trypanosoma cruzi Peptide deformylase 2, putative 0.0093 0.101 0.2772
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0054 0.0115
Schistosoma mansoni cpg binding protein 0.0031 0.0283 0.0603
Brugia malayi Variant SH3 domain containing protein 0.001 0.004 0.0118
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0126 0.0268
Loa Loa (eye worm) pip kinase 2 0.0173 0.1929 0.5191
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0167 0.0458
Brugia malayi Pip kinase protein 1 0.0014 0.009 0.0262
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0173 0.1929 0.4111

Activities

Activity type Activity value Assay description Source Reference
Control (functional) = 168 % Neurotrophic activity as measured by the ability to enhance basal forebraincholine acetyl transferase at 50 nM ChEMBL. 9191963
Control (functional) = 168 % Neurotrophic activity as measured by the ability to enhance basal forebraincholine acetyl transferase at 50 nM ChEMBL. 9191963
Control (functional) = 193 % Neurotrophic activity as measured by the ability to enhance embryonic rat spinal cord choline acetyl transferase at 30 nM ChEMBL. 9191963
Control (functional) = 193 % Neurotrophic activity as measured by the ability to enhance embryonic rat spinal cord choline acetyl transferase at 30 nM ChEMBL. 9191963
Control (functional) = 218 % Neurotrophic activity as measured by the ability to enhance embryonic rat spinal cord choline acetyl transferase at 300 nM ChEMBL. 9191963
Control (functional) = 218 % Neurotrophic activity as measured by the ability to enhance embryonic rat spinal cord choline acetyl transferase at 300 nM ChEMBL. 9191963
Control (functional) = 340 % Neurotrophic activity as measured by the ability to enhance basal forebraincholine acetyl transferase at 250 nM ChEMBL. 9191963
Control (functional) = 340 % Neurotrophic activity as measured by the ability to enhance basal forebraincholine acetyl transferase at 250 nM ChEMBL. 9191963
IC50 (binding) = 270 nM Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determined ChEMBL. 9191963
IC50 (binding) = 270 nM Ability to inhibit human trk A tyrosine kinase expressed in baculovirus using ELISA based enzyme assay was determined ChEMBL. 9191963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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