Detailed information for compound 827660

Basic information

Technical information
  • TDR Targets ID: 827660
  • Name: ethyl 4-[(1,5-dimethyl-4-oxopyrrolo[4,5-c]qui noline-2-carbonyl)amino]benzoate
  • MW: 403.431 | Formula: C23H21N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc(cc1)NC(=O)c1cc2c(n1C)c1ccccc1n(c2=O)C
  • InChi: 1S/C23H21N3O4/c1-4-30-23(29)14-9-11-15(12-10-14)24-21(27)19-13-17-20(25(19)2)16-7-5-6-8-18(16)26(3)22(17)28/h5-13H,4H2,1-3H3,(H,24,27)
  • InChiKey: AFKUXPIMZXOQBV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[(1,5-dimethyl-4-oxo-pyrrolo[4,5-c]quinoline-2-carbonyl)amino]benzoate
  • 4-[[(1,5-dimethyl-4-oxo-2-pyrrolo[4,5-c]quinolinyl)-oxomethyl]amino]benzoic acid ethyl ester
  • 4-[(4-keto-1,5-dimethyl-pyrrolo[4,5-c]quinoline-2-carbonyl)amino]benzoic acid ethyl ester
  • ethyl 4-[(1,5-dimethyl-4-oxo-pyrrolo[4,5-c]quinolin-2-yl)carbonylamino]benzoate
  • C593-0611
  • NCGC00110627-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0049 0.015
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0107 0.0306 0.0306
Echinococcus granulosus contactin 0.0027 0.0036 0.0051
Onchocerca volvulus 0.0017 0.0004 0.0002
Trypanosoma cruzi polo-like protein kinase, putative 0.0902 0.2984 1
Toxoplasma gondii thioredoxin reductase 0.0057 0.0138 0.107
Schistosoma mansoni vesicular amine transporter 0.0107 0.0306 0.0306
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0138 0.2437
Schistosoma mansoni hypothetical protein 0.0017 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0035 0.0063 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0121 0.0355 0.0508
Echinococcus multilocularis hemicentin 1 0.0023 0.0022 0.0032
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0025 0.0031 0.0045
Brugia malayi Bromodomain containing protein 0.0032 0.0055 0.0172
Echinococcus multilocularis lachesin 0.0023 0.0022 0.0032
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0027 0.0036 0.0051
Brugia malayi jmjC domain containing protein 0.0106 0.0304 0.1007
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0035 0.0065 0.0204
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0005 0.0004
Echinococcus multilocularis tyrosine protein kinase otk 0.0023 0.0022 0.0032
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0369 0.1187 0.1698
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0173 0.0528 1
Echinococcus granulosus roundabout 2 0.0134 0.0396 0.0566
Loa Loa (eye worm) hypothetical protein 0.0107 0.0306 0.1014
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.2092 0.6992 1
Leishmania major trypanothione reductase 0.0057 0.0138 0.0423
Echinococcus multilocularis GPCR, family 2 0.0018 0.0005 0.0007
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0173 0.0528 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0055 0.0364
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0036 0.0051
Echinococcus multilocularis peroxidasin 0.0023 0.0023 0.0033
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0173 0.0528 1
Echinococcus multilocularis neuroglian 0.012 0.0351 0.0502
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0434 0.8164
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0036 0.0106
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0173 0.0528 0.5771
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0121 0.0355 0.0508
Leishmania major protein kinase, putative 0.0369 0.1187 0.3954
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0172 0.0563
Loa Loa (eye worm) AUR protein kinase 0.0369 0.1187 0.3972
Schistosoma mansoni cpg binding protein 0.0034 0.006 0.006
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0026 0.0033 0.0099
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0173 0.0528 0.5771
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.006 0.0086
Leishmania major cytochrome p450-like protein 0.0173 0.0528 0.1736
Trypanosoma brucei cytochrome P450, putative 0.0285 0.0906 0.3008
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0036 0.0106
Trichomonas vaginalis AGC family protein kinase 0.0369 0.1187 0.3954
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0173 0.0528 0.5771
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0019 0.0049
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0173 0.0528 0.5771
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.0036 0.0036
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0434 0.3408
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0007
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0173 0.0528 0.1736
Loa Loa (eye worm) TK protein kinase 0.0135 0.04 0.1328
Brugia malayi Immunoglobulin I-set domain containing protein 0.0554 0.1813 0.6071
Trichomonas vaginalis AGC family protein kinase 0.0369 0.1187 0.3954
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0107 0.0306 0.0306
Schistosoma mansoni cpg binding protein 0.0032 0.0054 0.0054
Brugia malayi protein unc-22 0.0026 0.0033 0.0099
Loa Loa (eye worm) hypothetical protein 0.0038 0.0074 0.0234
Echinococcus multilocularis roundabout 2 0.0027 0.0036 0.0051
Echinococcus multilocularis Immunoglobulin 0.0107 0.0306 0.0438
Loa Loa (eye worm) CAMK protein kinase 0.0026 0.0033 0.0099
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Loa Loa (eye worm) AUR protein kinase 0.0369 0.1187 0.3972
Toxoplasma gondii cytochrome p450 superfamily protein 0.0173 0.0528 0.439
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.0304 0.0435
Loa Loa (eye worm) hypothetical protein 0.0056 0.0133 0.0433
Plasmodium vivax glutathione reductase, putative 0.0057 0.0138 0.107
Loa Loa (eye worm) cytochrome P450 family protein 0.0285 0.0906 0.3028
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Echinococcus multilocularis aurora kinase A 0.0369 0.1187 0.1698
Schistosoma mansoni cell adhesion molecule 0.012 0.0351 0.0351
Brugia malayi Cytochrome P450 family protein 0.0285 0.0906 0.3028
Schistosoma mansoni cell adhesion molecule 0.0017 0.0004 0.0004
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.006 0.0086
Schistosoma mansoni hypothetical protein 0.0456 0.148 0.148
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0173 0.0528 0.5771
Echinococcus multilocularis hemicentin 1 0.0023 0.0022 0.0032
Brugia malayi Immunoglobulin I-set domain containing protein 0.0135 0.04 0.1328
Trypanosoma cruzi aurora B kinase, putative 0.0369 0.1187 0.3954
Schistosoma mansoni hypothetical protein 0.0038 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0032 0.0055 0.0055
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.0304 0.0435
Loa Loa (eye worm) hypothetical protein 0.0112 0.0324 0.1074
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0173 0.0528 0.5771
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.006 0.006
Schistosoma mansoni cell adhesion molecule 0.0027 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0061
Brugia malayi Cytochrome P450 family protein 0.0173 0.0528 0.1759
Echinococcus granulosus peregrin 0.0032 0.0055 0.0079
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0016 0.0011
Echinococcus multilocularis 0.0173 0.0528 0.0756
Echinococcus granulosus GPCR family 2 0.0018 0.0005 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0434 0.8164
Mycobacterium leprae putative cytochrome p450 0.0173 0.0528 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0385 0.7214
Brugia malayi jmjC domain containing protein 0.0041 0.0084 0.027
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0173 0.0528 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0554 0.1813 0.6071
Brugia malayi hypothetical protein 0.0025 0.0029 0.0084
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0007
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.002 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0111 0.032 0.1059
Schistosoma mansoni cell adhesion molecule 0.0017 0.0004 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0111 0.032 0.1059
Echinococcus granulosus cytochrome P450 2K1 0.0173 0.0528 0.0756
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0055 0.0055
Brugia malayi Pre-SET motif family protein 0.0233 0.0729 0.2433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.006 0.006
Echinococcus granulosus tyrosine protein kinase Lyn 0.0021 0.0016 0.0023
Brugia malayi serine/threonine protein kinase 6 0.0369 0.1187 0.3972
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0107 0.0306 0.0438
Loa Loa (eye worm) TK/ROR protein kinase 0.0025 0.0031 0.0091
Brugia malayi serine/threonine-protein kinase 6 0.0369 0.1187 0.3972
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0013 0.5
Brugia malayi Thioredoxin reductase 0.0057 0.0138 0.045
Echinococcus multilocularis Immunoglobulin 0.0107 0.0306 0.0438
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0173 0.0528 0.1736
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.0022 0.0061
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0369 0.1187 0.3947
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0173 0.0528 1
Schistosoma mansoni neuroglian 0.0027 0.0036 0.0036
Schistosoma mansoni cell adhesion molecule 0.0027 0.0036 0.0036
Trypanosoma brucei polo-like protein kinase 0.0902 0.2984 1
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0173 0.0528 1
Echinococcus granulosus Immunoglobulin 0.0107 0.0306 0.0438
Schistosoma mansoni titin 0.0026 0.0033 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0074 0.0234
Echinococcus granulosus nephrin 0.0017 0.0004 0.0006
Schistosoma mansoni titin 0.0017 0.0004 0.0004
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0022 0.0061
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0173 0.0528 0.5771
Loa Loa (eye worm) cytochrome P450 family protein 0.0699 0.2299 0.7702
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0173 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.032 0.1059
Onchocerca volvulus 0.0025 0.0029 0.0086
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0173 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0055 0.0172
Trypanosoma cruzi cytochrome P450, putative 0.0285 0.0906 0.3008
Echinococcus granulosus dnaJ subfamily B 0.0456 0.148 0.2117
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.0036 0.0051
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0369 0.1187 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.002 0.0013 0.0018
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0138 0.107
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0231 0.0231
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.002 0.002
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Trypanosoma brucei trypanothione reductase 0.0057 0.0138 0.0423
Echinococcus multilocularis twitchin 0.0022 0.002 0.0029
Loa Loa (eye worm) hypothetical protein 0.0116 0.0338 0.112
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.2092 0.6992 1
Echinococcus multilocularis activin receptor type 0.0021 0.0016 0.0023
Treponema pallidum NADH oxidase 0.002 0.0013 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0029 0.014
Loa Loa (eye worm) CYP4Cod1 0.0285 0.0906 0.3028
Schistosoma mansoni serine/threonine protein kinase 0.0369 0.1187 0.1187
Plasmodium falciparum phd finger protein, putative 0.0032 0.0055 0.0364
Giardia lamblia Kinase, PLK 0.0902 0.2984 1
Onchocerca volvulus 0.0026 0.0033 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0013 0.0013
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0084 0.027
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0022 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0179 0.0179
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0173 0.0528 0.5771
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0027 0.0036 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0106
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0173 0.0528 0.5771
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0173 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0005 0.0004
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0369 0.1187 0.3947
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0173 0.0528 1
Schistosoma mansoni serine/threonine protein kinase 0.0026 0.0033 0.0033
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.002 0.0013 0.0018
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0098 0.014
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0902 0.2984 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0121 0.0355 0.0508
Echinococcus granulosus neuroglian 0.012 0.0351 0.0502
Echinococcus multilocularis slit 2 protein 0.0017 0.0004 0.0006
Toxoplasma gondii aurora kinase 0.0369 0.1187 1
Toxoplasma gondii hypothetical protein 0.0025 0.0029 0.014
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0022 0.0061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0061
Echinococcus granulosus peroxidasin 0.0023 0.0023 0.0033
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0022 0.0061
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0173 0.0528 0.5771
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.006 0.006
Brugia malayi CXXC zinc finger family protein 0.0032 0.0054 0.0167
Echinococcus granulosus activin receptor type 0.0021 0.0016 0.0023
Brugia malayi PHD-finger family protein 0.0032 0.0055 0.0172
Brugia malayi Fibronectin type III domain containing protein 0.0111 0.032 0.1059
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0138 0.0423
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0173 0.0528 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0025 0.0031 0.0045
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.0036 0.0051
Onchocerca volvulus Tyrosine kinase homolog 0.0451 0.1466 0.4907
Onchocerca volvulus 0.0032 0.0054 0.0169
Brugia malayi hypothetical protein 0.0111 0.032 0.1059
Schistosoma mansoni nephrin 0.0124 0.0364 0.0364
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0173 0.0528 0.5771
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0078 0.0112
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0116 0.0338 0.0483
Echinococcus granulosus titin 0.0026 0.0033 0.0048
Loa Loa (eye worm) cytochrome P450 0.0173 0.0528 0.1759
Entamoeba histolytica protein kinase domain containing protein 0.0369 0.1187 0.3947
Schistosoma mansoni protein kinase 0.0021 0.0016 0.0016
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0173 0.0528 0.5771
Loa Loa (eye worm) cytochrome P450 family protein 0.0285 0.0906 0.3028
Leishmania major protein kinase, putative 0.0021 0.0016 0.0011
Echinococcus granulosus slit 2 protein 0.0017 0.0004 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0434 0.8164
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.002 0.0013 0.0029
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0138 0.0198
Onchocerca volvulus Slit protein homolog 0.0017 0.0004 0.0003
Echinococcus granulosus defective proboscis extension response 0.0107 0.0306 0.0438
Schistosoma mansoni myosin-binding protein-related 0.0017 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0111 0.032 0.1059
Echinococcus granulosus cpg binding protein 0.0034 0.006 0.0086
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0902 0.2984 0.4267
Loa Loa (eye worm) hypothetical protein 0.0107 0.0307 0.1017
Echinococcus granulosus hemicentin 1 0.0023 0.0022 0.0032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0385 0.7214
Echinococcus granulosus titin 0.0026 0.0033 0.0048
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.0036 0.0051
Brugia malayi Cytochrome P450 family protein 0.0699 0.2299 0.7702
Echinococcus granulosus twitchin 0.0129 0.038 0.0544
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0173 0.0528 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0285 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.006 0.0189
Trypanosoma brucei protein kinase, putative 0.0021 0.0016 0.0011
Entamoeba histolytica serine/threonine protein kinase, putative 0.0902 0.2984 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0902 0.2984 0.4267
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0084 0.0084
Brugia malayi Immunoglobulin I-set domain containing protein 0.0026 0.0033 0.0099
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Plasmodium falciparum glutathione reductase 0.0057 0.0138 0.107
Schistosoma mansoni protein kinase 0.0021 0.0016 0.0016
Schistosoma mansoni cell adhesion molecule 0.0023 0.0022 0.0022
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0055 0.0079
Onchocerca volvulus 0.0017 0.0004 0.0002
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.002 0.0013 0.5
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0023 0.0022 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0173 0.0528 0.5771
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0173 0.0528 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0173 0.0528 1
Schistosoma mansoni serine/threonine protein kinase 0.0902 0.2984 0.2984
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0061
Plasmodium falciparum protein kinase, putative 0.0021 0.0016 0.0029
Leishmania major cytochrome p450-like protein 0.0173 0.0528 0.1736
Echinococcus multilocularis titin 0.0026 0.0033 0.0048
Brugia malayi Peroxidasin 0.0023 0.0023 0.0063
Echinococcus multilocularis neuroglian 0.0027 0.0036 0.0051
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0061
Trypanosoma brucei aurora B kinase 0.0369 0.1187 0.3954
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0173 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0029 0.0084
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0385 0.7214
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0098 0.014
Echinococcus multilocularis peregrin 0.0032 0.0055 0.0079
Onchocerca volvulus 0.0426 0.1381 0.4621
Onchocerca volvulus Alhambra homolog 0.0032 0.0055 0.0174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0005 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Echinococcus multilocularis roundabout 2 0.0134 0.0396 0.0566
Loa Loa (eye worm) hypothetical protein 0.013 0.0382 0.127
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Schistosoma mansoni septate junction protein 0.0023 0.0022 0.0022
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0055 0.0364
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0173 0.0528 0.5771
Brugia malayi serine/threonine kinase 12 0.0369 0.1187 0.3972
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0138 0.0198
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0173 0.0528 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.0729 0.2433
Echinococcus granulosus neuroglian 0.0027 0.0036 0.0051
Schistosoma mansoni nephrin 0.0027 0.0036 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0385 0.7214
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0084 0.0084
Schistosoma mansoni titin 0.0023 0.0022 0.0022
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0138 0.045
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.0022 0.0061
Loa Loa (eye worm) hypothetical protein 0.0056 0.0133 0.0434
Trichomonas vaginalis AGC family protein kinase 0.0369 0.1187 0.3954
Schistosoma mansoni protein kinase 0.0369 0.1187 0.1187
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0023 0.0022 0.0063
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0173 0.0528 0.1736
Echinococcus granulosus tyrosine protein kinase otk 0.0023 0.0022 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0055 0.0364
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0055 0.0172
Loa Loa (eye worm) AUR protein kinase 0.0369 0.1187 0.3972
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0173 0.0528 0.5771
Schistosoma mansoni cytochrome P450 0.0173 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.013 0.0382 0.127
Mycobacterium tuberculosis Probable reductase 0.013 0.0385 0.7214
Echinococcus granulosus aurora kinase A 0.0369 0.1187 0.1698
Brugia malayi hypothetical protein 0.0351 0.1129 0.3776
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0173 0.0528 0.5771
Echinococcus granulosus roundabout 2 0.0027 0.0036 0.0051
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0173 0.0528 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0154 0.1205
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0021 0.0016 0.0023
Onchocerca volvulus 0.0034 0.006 0.0191
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0005 0.0007
Onchocerca volvulus Serine\/threonine kinase homolog 0.0902 0.2984 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0133 0.0433
Plasmodium falciparum serine/threonine protein kinase, putative 0.0369 0.1187 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0022 0.0061
Echinococcus multilocularis transfer RNA-Phe 0.0017 0.0004 0.0006
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0173 0.0528 0.1736
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0005 0.0004
Entamoeba histolytica protein kinase , putative 0.0369 0.1187 0.3947
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0054 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0133 0.0433
Schistosoma mansoni septate junction protein 0.0023 0.0022 0.0022
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0022 0.0061
Echinococcus granulosus roundabout 2 0.0027 0.0036 0.0051
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0021 0.0016 0.0029
Trichomonas vaginalis AGC family protein kinase 0.0369 0.1187 0.3954
Loa Loa (eye worm) hypothetical protein 0.0351 0.1129 0.3776
Schistosoma mansoni cpg binding protein 0.0034 0.006 0.006
Entamoeba histolytica protein kinase, putative 0.0369 0.1187 0.3947
Brugia malayi Pre-SET motif family protein 0.0034 0.006 0.0189
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0055 0.0079
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.002 0.0013 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0027 0.0036 0.0106
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0121 0.0355 0.0508
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0173 0.0528 1
Leishmania major cytochrome p450-like protein 0.0285 0.0906 0.3008
Giardia lamblia Aurora kinase 0.0369 0.1187 0.3954
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0029 0.014
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0084 0.0121
Loa Loa (eye worm) hypothetical protein 0.0107 0.0306 0.1014
Schistosoma mansoni roundabout 0.0023 0.0022 0.0022
Trypanosoma cruzi cytochrome P450, putative 0.0285 0.0906 0.3008
Brugia malayi Prion-like- 0.0023 0.0022 0.0061
Echinococcus multilocularis cpg binding protein 0.0034 0.006 0.0086
Echinococcus multilocularis roundabout 2 0.0027 0.0036 0.0051
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0173 0.0528 0.5771
Schistosoma mansoni protein kinase 0.0021 0.0016 0.0016
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.006 0.0406
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0063
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0369 0.1187 0.3947
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Brugia malayi serine/threonine-protein kinase plk-2 0.0902 0.2984 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0902 0.2984 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0902 0.2984 1
Echinococcus granulosus lachesin 0.0023 0.0022 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0054 0.0077
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0021 0.0016 0.0023
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0173 0.0528 0.1736
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0005 0.0004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0133 0.0433
Schistosoma mansoni hemicentin 0.0017 0.0004 0.0004
Trichomonas vaginalis set domain proteins, putative 0.0265 0.0837 0.2775
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0173 0.0528 0.5771
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0023 0.0022 0.0022
Giardia lamblia PHD finger protein 15 0.0032 0.0055 0.0144
Entamoeba histolytica protein kinase, putative 0.0369 0.1187 0.3947
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0049 0.015
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.006 0.0086
Schistosoma mansoni hypothetical protein 0.0018 0.0005 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0017 0.0004 0.0006
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0016 0.0011
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0385 0.7214
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0369 0.1187 0.1698
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0029 0.0055
Brugia malayi Cytochrome P450 family protein 0.0285 0.0906 0.3028
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0173 0.0528 0.5771
Brugia malayi cytochrome P450 0.0173 0.0528 0.1759
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0173 0.0528 1
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0021 0.0016 0.0011
Plasmodium vivax SET domain protein, putative 0.0034 0.006 0.0406
Brugia malayi glutathione reductase 0.0057 0.0138 0.045
Trichomonas vaginalis CAMK family protein kinase 0.0902 0.2984 1
Echinococcus multilocularis dnaJ subfamily B 0.0456 0.148 0.2117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0061
Plasmodium falciparum thioredoxin reductase 0.0057 0.0138 0.107
Schistosoma mansoni hypothetical protein 0.0173 0.0528 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.006 0.006
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0173 0.0528 0.5771
Schistosoma mansoni tyrosine kinase 0.0121 0.0355 0.0355
Mycobacterium leprae Conserved hypothetical protein 0.0173 0.0528 1
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0173 0.0528 1
Loa Loa (eye worm) glutathione reductase 0.0057 0.0138 0.045
Onchocerca volvulus 0.0265 0.0837 0.2797

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3162 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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