Detailed information for compound 842961

Basic information

Technical information
  • TDR Targets ID: 842961
  • Name: 4-tert-butyl-N-[(5,7-dimethyl-[1,2,4]triazolo [1,5-a]pyrimidin-2-yl)methyl]benzenesulfonami de
  • MW: 373.473 | Formula: C18H23N5O2S
  • H donors: 1 H acceptors: 5 LogP: 3.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)n2c(n1)nc(n2)CNS(=O)(=O)c1ccc(cc1)C(C)(C)C
  • InChi: 1S/C18H23N5O2S/c1-12-10-13(2)23-17(20-12)21-16(22-23)11-19-26(24,25)15-8-6-14(7-9-15)18(3,4)5/h6-10,19H,11H2,1-5H3
  • InChiKey: VGJMSUGEIMXECB-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0108 0.0851 0.5843
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Schistosoma mansoni hypothetical protein 0.0114 0.09 0.09
Onchocerca volvulus 0.0027 0.0139 0.031
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0046 0.0301 0.029
Loa Loa (eye worm) matrixin family protein 0.0178 0.1466 0.2627
Echinococcus granulosus caspase 2 0.0047 0.0312 0.0301
Brugia malayi N-terminal motif family protein 0.0158 0.129 0.2312
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0139 0.079
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0099 0.0087
Loa Loa (eye worm) bromodomain containing protein 0.0013 0.0016 0.0022
Echinococcus multilocularis caspase 0.0014 0.0022 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0028 0.0742
Schistosoma mansoni hypothetical protein 0.0033 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0047 0.0312 0.0554
Mycobacterium tuberculosis Conserved protein 0.0027 0.0139 0.0785
Loa Loa (eye worm) beta-lactamase 0.0027 0.0139 0.0243
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0097 0.0755 0.8657
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0021 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0225 0.0225
Schistosoma mansoni inositol monophosphatase 0.0036 0.0211 0.0211
Brugia malayi Latrophilin receptor protein 2 0.0013 0.0013 0.0017
Entamoeba histolytica hypothetical protein 0.0044 0.0286 0.5886
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0211 0.1813
Loa Loa (eye worm) hypothetical protein 0.008 0.0605 0.108
Trypanosoma brucei metacaspase MCA2 0.0014 0.0022 0.0588
Brugia malayi Cell death protein 3 precursor 0.0047 0.0312 0.0554
Toxoplasma gondii melibiase subfamily protein 0.0093 0.0712 0.6389
Echinococcus multilocularis geminin 0.0446 0.3822 0.3814
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0044 0.0286 0.1789
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0028 0.0145 0.0145
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0211 0.02
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0027 0.0139 0.1513
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0139 0.0139
Trichomonas vaginalis set domain proteins, putative 0.0182 0.1496 1
Onchocerca volvulus 0.0182 0.1496 1
Mycobacterium tuberculosis Probable lipase LipE 0.0027 0.0139 0.0785
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0028 0.0145 0.0133
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0097 0.0755 0.5163
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0016
Loa Loa (eye worm) hypothetical protein 0.0013 0.0013 0.0017
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0049 0.0333 0.0321
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0046 0.0301 0.0301
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0097 0.0755 0.5163
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0013 0.0013 0.0001
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0066 0.0482 0.0482
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0139 0.4848
Schistosoma mansoni hypothetical protein 0.0262 0.2203 0.2203
Brugia malayi MH2 domain containing protein 0.0105 0.0819 0.1465
Schistosoma mansoni zinc finger protein 0.0019 0.0064 0.0064
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0028 0.0145 0.0133
Plasmodium falciparum glutathione reductase 0.0015 0.0028 0.0164
Loa Loa (eye worm) matrixin family protein 0.0194 0.1607 0.2881
Plasmodium falciparum thioredoxin reductase 0.0043 0.0274 0.7101
Loa Loa (eye worm) hypothetical protein 0.0049 0.0329 0.0586
Schistosoma mansoni inositol monophosphatase 0.0036 0.0211 0.0211
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0211 0.1283
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.2073 0.2063
Entamoeba histolytica hypothetical protein 0.0061 0.0437 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0027 0.0139 0.0127
Entamoeba histolytica hypothetical protein 0.0061 0.0437 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0097 0.0755 0.5163
Echinococcus multilocularis GPCR, family 2 0.0013 0.0013 0.0001
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0028 0.0039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0099 0.0087
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.002 0.007 0.1344
Schistosoma mansoni ran 0.002 0.007 0.007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0061 0.0049
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0027 0.0139 0.0785
Plasmodium vivax glutathione reductase, putative 0.0043 0.0274 0.7101
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0046 0.0301 0.0535
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0024 0.0111 0.0897
Brugia malayi Pre-SET motif family protein 0.0024 0.0111 0.0193
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0014 0.0022 0.0022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0176 0.1447 0.1437
Schistosoma mansoni ran 0.002 0.007 0.007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0049 0.0333 0.0321
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0061 0.0049
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.002 0.007 0.0119
Schistosoma mansoni hypothetical protein 0.058 0.5007 0.5007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0341 0.0607
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0013
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0028 0.0164
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0013
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0014 0.0022 0.0084
Onchocerca volvulus 0.0033 0.0187 0.0659
Loa Loa (eye worm) STAT protein 0.0644 0.557 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0243
Loa Loa (eye worm) hypothetical protein 0.0033 0.0187 0.0331
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.004 0.0118
Echinococcus multilocularis zinc finger protein 0.0019 0.0064 0.0053
Echinococcus multilocularis dnaJ subfamily B 0.0619 0.5342 0.5337
Leishmania major metacaspase, putative 0.0014 0.0022 0.0734
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0014 0.0022 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0176 0.1447 0.1447
Schistosoma mansoni caspase-7 (C14 family) 0.0014 0.0022 0.0022
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0046 0.0301 0.029
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0139 0.3287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.004 0.0118
Echinococcus granulosus lamin 0.0022 0.0095 0.0083
Plasmodium falciparum importin beta, putative 0.0054 0.0376 1
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.0105 0.0819 0.1465
Schistosoma mansoni hypothetical protein 0.0016 0.0036 0.0036
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0977
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0028 0.0039
Echinococcus multilocularis lamin dm0 0.0022 0.0095 0.0083
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0274 0.9575
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0742
Schistosoma mansoni methyl-cpg binding protein mbd 0.0013 0.0012 0.0012
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0098 0.0759 0.5189
Onchocerca volvulus 0.0071 0.0524 0.306
Schistosoma mansoni caspase-7 (C14 family) 0.0047 0.0312 0.0312
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0108 0.0851 0.5843
Schistosoma mansoni caspase-3 (C14 family) 0.0014 0.0022 0.0022
Echinococcus granulosus caspase 8 0.0014 0.0022 0.001
Trichomonas vaginalis importin beta-1, putative 0.0044 0.0286 0.1789
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.007 0.244
Trypanosoma brucei metacaspase 5, putative 0.0014 0.0022 0.0588
Loa Loa (eye worm) hypothetical protein 0.0054 0.0376 0.067
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0225 0.0214
Schistosoma mansoni cpg binding protein 0.0071 0.0524 0.0524
Echinococcus granulosus intermediate filament protein 0.0022 0.0095 0.0083
Onchocerca volvulus Matrilysin homolog 0.0178 0.1466 0.9785
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0977
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.004 0.0118
Onchocerca volvulus 0.0043 0.0277 0.1298
Schistosoma mansoni sex comb on midleg homolog 0.0043 0.0277 0.0277
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0046 0.0301 0.194
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0028 0.5
Schistosoma mansoni hypothetical protein 0.0013 0.0013 0.0013
Brugia malayi beta-lactamase family protein 0.0027 0.0139 0.0243
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0043 0.0274 0.0486
Echinococcus granulosus SAM and MBT domain containing protein 0.0043 0.0277 0.0265
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0145 0.0834
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0013 0.0013 0.0001
Trypanosoma cruzi metacaspase 5, putative 0.0014 0.0022 0.0774
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0176 0.1447 0.1437
Trichomonas vaginalis helicase, putative 0.0016 0.004 0.0118
Echinococcus granulosus thioredoxin glutathione reductase 0.0043 0.0274 0.0262
Trichomonas vaginalis ran, putative 0.002 0.007 0.0323
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0243
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0028 0.0927
Toxoplasma gondii HEAT repeat-containing protein 0.0054 0.0376 0.3321
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0139 0.079
Echinococcus granulosus dnaJ subfamily B 0.0619 0.5342 0.5337
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.002 0.007 0.1344
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0093 0.0712 0.0712
Echinococcus multilocularis caspase 8 0.0014 0.0022 0.001
Loa Loa (eye worm) hypothetical protein 0.0041 0.0263 0.0466
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0028 0.0145 1
Trypanosoma cruzi metacaspase, putative 0.0014 0.0022 0.0774
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0211 0.02
Brugia malayi intermediate filament protein 0.0022 0.0095 0.0165
Schistosoma mansoni hypothetical protein 0.0446 0.3822 0.3822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0024 0.0111 0.0111
Schistosoma mansoni myelin transcription factor 1 myt1 0.0049 0.0329 0.0329
Toxoplasma gondii thioredoxin reductase 0.0043 0.0274 0.2382
Leishmania major hypothetical protein, conserved 0.0027 0.0139 0.4599
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0044 0.0286 0.1789
Echinococcus multilocularis SAM and MBT domain containing protein 0.0043 0.0277 0.0265
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0243
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0028 0.0145 0.0254
Loa Loa (eye worm) hypothetical protein 0.0028 0.0145 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Trypanosoma brucei metacaspase MCA3 0.0014 0.0022 0.0588
Loa Loa (eye worm) histone methyltransferase 0.0023 0.0099 0.0171
Schistosoma mansoni survival motor neuron protein 0.005 0.0341 0.0341
Mycobacterium tuberculosis Conserved protein 0.0027 0.0139 0.0785
Echinococcus granulosus lamin dm0 0.0022 0.0095 0.0083
Schistosoma mansoni transcription factor LCR-F1 0.0061 0.0437 0.0437
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0742
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0043 0.0277 0.1298
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0014 0.0022 0.0084
Onchocerca volvulus Matrilysin homolog 0.008 0.0605 0.3638
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0013 0.0013 0.0013
Echinococcus multilocularis ubiquitin specific protease 41 0.0028 0.0145 0.0133
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.002 0.007 0.1853
Echinococcus granulosus polycomb protein SCMH1 0.0043 0.0277 0.0265
Trichomonas vaginalis esterase, putative 0.0027 0.0139 0.079
Trypanosoma cruzi importin beta-1 subunit, putative 0.0044 0.0286 1
Schistosoma mansoni hypothetical protein 0.0028 0.0147 0.0147
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0225 0.0214
Loa Loa (eye worm) hypothetical protein 0.0014 0.0022 0.0034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0165
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0062 0.0441 0.0441
Trypanosoma brucei importin beta-1 subunit, putative 0.0054 0.0376 1
Onchocerca volvulus 0.0027 0.0139 0.031
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0028 0.0742
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.002 0.007 0.0519
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0176 0.1447 0.2593
Onchocerca volvulus 0.0114 0.09 0.5747
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0468 0.4021 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0139 0.079
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0093 0.0712 0.0701
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0093 0.0712 0.0701
Echinococcus granulosus zinc finger protein 0.0019 0.0064 0.0053
Echinococcus granulosus importin subunit beta 1 0.0054 0.0376 0.0365
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0178 0.056
Onchocerca volvulus 0.0024 0.0111 0.0114
Brugia malayi Melibiase family protein 0.0062 0.0441 0.0786
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0093 0.0712 0.0712
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0176 0.1447 0.1437
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.2073 0.2063
Schistosoma mansoni bromodomain containing protein 0.0052 0.0357 0.0357
Brugia malayi Matrixin family protein 0.008 0.0605 0.108
Mycobacterium tuberculosis Probable lipase LipD 0.0027 0.0139 0.0785
Mycobacterium tuberculosis Probable hydrolase 0.0027 0.0139 0.0785
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0028 0.0145 0.0145
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.016 0.1304 0.2336
Brugia malayi Matrixin family protein 0.008 0.0605 0.108
Loa Loa (eye worm) matrix metalloproteinase 0.008 0.0605 0.108
Brugia malayi beta-lactamase 0.0027 0.0139 0.0243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0927
Schistosoma mansoni lamin 0.0022 0.0095 0.0095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0028 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0041 0.0263 0.0466
Echinococcus multilocularis importin subunit beta 1 0.0054 0.0376 0.0365
Brugia malayi Hemopexin family protein 0.0114 0.09 0.1611
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0024 0.0111 0.0099
Schistosoma mansoni lamin 0.0022 0.0095 0.0095
Echinococcus granulosus ubiquitin specific protease 41 0.0028 0.0145 0.0133
Brugia malayi Importin beta-1 subunit 0.0054 0.0376 0.067
Echinococcus granulosus caspase 0.0014 0.0022 0.001
Plasmodium falciparum glutathione reductase 0.0043 0.0274 0.7101
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.0301 0.3739
Brugia malayi Matrixin family protein 0.008 0.0605 0.108
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0028 0.0145 0.0133
Brugia malayi Matrixin family protein 0.008 0.0605 0.108
Echinococcus granulosus snurportin 1 0.058 0.5007 0.5001
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0292 0.2468 0.2459
Echinococcus multilocularis cpg binding protein 0.0077 0.0572 0.0561
Loa Loa (eye worm) glutathione reductase 0.0043 0.0274 0.0485
Loa Loa (eye worm) latrophilin receptor protein 2 0.0013 0.0013 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0071 0.0524 0.0935
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0013 0.0013 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0225 0.0398
Leishmania major trypanothione reductase 0.0043 0.0274 0.9084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0927
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0977
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0093 0.0712 0.0712
Echinococcus multilocularis lamin 0.0022 0.0095 0.0083
Brugia malayi Thioredoxin reductase 0.0043 0.0274 0.0485
Brugia malayi beta-lactamase family protein 0.0027 0.0139 0.0243
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0028 0.0145 0.2052
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0211 0.0459
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0139 0.4848
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0175 0.1436 1
Schistosoma mansoni sex comb on midleg homolog 0.0043 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0054 0.0371 0.066
Echinococcus multilocularis thioredoxin glutathione reductase 0.0043 0.0274 0.0262
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0021 0.0084 0.0073
Trypanosoma brucei Metacaspase-4 0.0014 0.0022 0.0588
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0028 0.0137
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.004 0.0118
Echinococcus granulosus histone acetyltransferase MYST2 0.0049 0.0329 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0176 0.1447 0.1437
Loa Loa (eye worm) hypothetical protein 0.0247 0.2073 0.3717
Entamoeba histolytica hypothetical protein 0.0061 0.0437 1
Loa Loa (eye worm) mbt repeat family protein 0.0043 0.0277 0.0491
Loa Loa (eye worm) PHD-finger family protein 0.0016 0.0036 0.0058
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0028 0.0145 0.4816
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0274 0.0485
Brugia malayi latrophilin 2 splice variant baaae 0.0028 0.0147 0.0258
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0016
Loa Loa (eye worm) hypothetical protein 0.0043 0.0277 0.0491
Schistosoma mansoni hypothetical protein 0.0061 0.0437 0.0437
Mycobacterium tuberculosis Probable dehydrogenase 0.0097 0.0755 0.5163
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0028 0.0145 0.0834
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.017 0.1392 0.1382
Onchocerca volvulus Cell death protein 3 homolog 0.0047 0.0312 0.1548
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0097 0.0755 0.5163
Brugia malayi Inositol-1 0.0036 0.0211 0.0373
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0013 0.0013 0.0001
Brugia malayi mbt repeat family protein 0.0043 0.0277 0.0491
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0028 0.0145 0.0133
Brugia malayi hypothetical protein 0.0247 0.2073 0.3717
Trypanosoma brucei trypanothione reductase 0.0043 0.0274 0.7271
Mycobacterium ulcerans hydrolase 0.0098 0.0759 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.004 0.0118
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0046 0.0301 1
Plasmodium vivax SET domain protein, putative 0.0024 0.0111 0.2511
Echinococcus granulosus cpg binding protein 0.0077 0.0572 0.0561
Loa Loa (eye worm) hypothetical protein 0.0028 0.0147 0.0258
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.002 0.007 0.0119
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.0145 0.5076
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0211 0.1283
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0211 0.7393
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.002 0.007 0.3567
Schistosoma mansoni hypothetical protein 0.005 0.0341 0.0341
Schistosoma mansoni methyl-cpg binding protein mbd 0.0013 0.0012 0.0012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0061 0.0437 0.0425
Mycobacterium ulcerans lipase LipD 0.0027 0.0139 0.1513
Schistosoma mansoni polycystin 1-related 0.0041 0.026 0.026
Schistosoma mansoni intermediate filament proteins 0.0022 0.0095 0.0095
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.0145 0.5076
Brugia malayi Calcitonin receptor-like protein seb-1 0.0041 0.0263 0.0466
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0027 0.0139 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0139 0.3681
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0013 0.0013 0.0017
Onchocerca volvulus 0.0027 0.0139 0.031
Onchocerca volvulus 0.008 0.0605 0.3638
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.002 0.007 0.244
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0211 0.5615
Echinococcus granulosus endonuclease exonuclease phosphatase 0.017 0.1392 0.1382
Echinococcus multilocularis snurportin 1 0.058 0.5007 0.5001
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0095 0.0165
Onchocerca volvulus Matrix metalloproteinase homolog 0.0178 0.1466 0.9785
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0027 0.0139 0.0243
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0049 0.0329 0.0586
Treponema pallidum NADH oxidase 0.0015 0.0028 0.5
Onchocerca volvulus 0.005 0.0341 0.1758
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0041 0.0263 0.0466
Brugia malayi mbt repeat family protein 0.0043 0.0277 0.0491
Plasmodium vivax importin-beta 2, putative 0.0054 0.0376 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0028 0.0028
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0093 0.0712 0.0701
Echinococcus multilocularis microtubule associated protein 2 0.1148 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0211 0.2508
Leishmania major importin beta-1 subunit, putative 0.0044 0.0286 0.9487
Brugia malayi RNA, U transporter 1 0.0155 0.1259 0.2255
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0028 0.0927
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0211 0.7015
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0028 0.0137
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0158 0.129 0.8533
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Brugia malayi Matrixin family protein 0.0194 0.1607 0.2881
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0049 0.0329 0.0318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0243
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0062 0.0441 0.0441
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0028 0.0145 0.3855
Entamoeba histolytica hypothetical protein 0.0061 0.0437 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0243
Brugia malayi PHD-finger family protein 0.0023 0.01 0.0174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0211 0.1283
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.03
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0243
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.004 0.0118
Loa Loa (eye worm) MBCTL1 0.0049 0.0329 0.0586
Echinococcus multilocularis caspase 2 0.0047 0.0312 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0977
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0028 0.0145 0.0834
Brugia malayi Bromodomain containing protein 0.0061 0.0435 0.0775
Loa Loa (eye worm) hypothetical protein 0.008 0.0605 0.108
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0046 0.0301 0.3739
Loa Loa (eye worm) hypothetical protein 0.008 0.0605 0.108
Schistosoma mansoni importin beta-1 0.0054 0.0376 0.0376
Mycobacterium leprae PROBABLE HYDROLASE 0.0098 0.0759 0.8707
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0211 0.7393
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0014 0.0022 0.001
Brugia malayi Pre-SET motif family protein 0.016 0.1304 0.2336
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0095 0.0165
Echinococcus multilocularis musashi 0.0022 0.0095 0.0083
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.058 0.5007 0.8988
Trypanosoma cruzi metacaspase, putative 0.0014 0.0022 0.0774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0176 0.1447 0.1447
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0028 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0028 0.0977
Brugia malayi CXXC zinc finger family protein 0.0071 0.0524 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Loa Loa (eye worm) inositol-1 0.0036 0.0211 0.0373
Plasmodium falciparum thioredoxin reductase 0.0015 0.0028 0.0164
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0028 0.0164
Echinococcus granulosus fetal alzheimer antigen falz 0.0021 0.0084 0.0073
Loa Loa (eye worm) hypothetical protein 0.0098 0.0759 0.1357
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0014 0.0022 0.001
Schistosoma mansoni cpg binding protein 0.0077 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0022 0.0091 0.0158
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0211 0.3856
Brugia malayi hypothetical protein 0.0033 0.0187 0.0331
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0061 0.0049
Mycobacterium ulcerans esterase/lipase LipP 0.0027 0.0139 0.1513
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.008 0.0605 0.0605
Echinococcus multilocularis apoptotic protease activating factor 1 0.0033 0.0187 0.0176
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0028 0.0164
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0028 0.0977
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0176 0.1447 0.1447
Mycobacterium ulcerans hypothetical protein 0.0027 0.0139 0.1513
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0152 0.1233 0.1233
Trichomonas vaginalis penicillin-binding protein, putative 0.0027 0.0139 0.079
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0109 0.019
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0028 0.0977
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0178 0.1068
Loa Loa (eye worm) hypothetical protein 0.0036 0.0219 0.0387
Brugia malayi STAT protein, DNA binding domain containing protein 0.0644 0.557 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.002 0.007 0.0058
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0176 0.1447 0.2593
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0027 0.0138 0.0126
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0061 0.0061
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0028 0.0164
Loa Loa (eye worm) transcription factor SMAD2 0.0105 0.0819 0.1465
Mycobacterium ulcerans beta-lactamase 0.0027 0.0139 0.1513
Toxoplasma gondii ABC1 family protein 0.0027 0.0139 0.1148
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0292 0.2468 0.2459
Brugia malayi hypothetical protein 0.0061 0.0437 0.0778
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0061 0.0437 0.0425
Mycobacterium tuberculosis Probable oxidoreductase 0.0108 0.0851 0.5843
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0108 0.0851 1
Brugia malayi glutathione reductase 0.0043 0.0274 0.0485
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.004 0.0118
Trichomonas vaginalis D-aminoacylase, putative 0.0027 0.0139 0.079
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0049 0.0329 0.0318
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.0111 0.0111
Echinococcus granulosus geminin 0.0446 0.3822 0.3814
Echinococcus granulosus GPCR family 2 0.0013 0.0013 0.0001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0027 0.0139 0.0785
Loa Loa (eye worm) hypothetical protein 0.0158 0.129 0.2312
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0062 0.0441 0.284
Trypanosoma brucei importin beta-1 subunit, putative 0.0054 0.0376 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0049 0.0329 0.0318
Loa Loa (eye worm) hypothetical protein 0.0062 0.0441 0.0786
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0014 0.0022 0.0034
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0098 0.0759 0.1357
Mycobacterium tuberculosis Conserved protein 0.0027 0.0139 0.0785
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0043 0.0277 0.0277
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0095 0.0165
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0016 0.004 0.0118
Leishmania major GTP-binding protein, putative 0.002 0.007 0.2315
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0027 0.0139 0.0785
Mycobacterium tuberculosis Probable esterase LipL 0.0027 0.0139 0.0785
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0027 0.0138 0.0126
Mycobacterium tuberculosis Probable reductase 0.0097 0.0755 0.5163
Echinococcus multilocularis polycomb protein SCMH1 0.0043 0.0277 0.0265
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0225 0.0225
Trypanosoma cruzi metacaspase, putative 0.0014 0.0022 0.0774
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0093 0.0712 0.0712
Schistosoma mansoni microtubule-associated protein tau 0.1148 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.004 0.0118
Toxoplasma gondii histone lysine methyltransferase SET1 0.0137 0.1107 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0022 0.009 0.0078
Echinococcus granulosus GTP binding nuclear protein Ran 0.002 0.007 0.0058
Schistosoma mansoni hypothetical protein 0.0619 0.5342 0.5342
Trypanosoma cruzi metacaspase, putative 0.0014 0.0022 0.0774
Schistosoma mansoni cpg binding protein 0.0077 0.0572 0.0572
Brugia malayi Bromodomain containing protein 0.0029 0.0154 0.027
Trypanosoma brucei metacaspase 0.0014 0.0022 0.0588
Echinococcus multilocularis beta LACTamase domain containing family member 0.0027 0.0139 0.0127
Trypanosoma cruzi metacaspase 5, putative 0.0014 0.0022 0.0774
Loa Loa (eye worm) hypothetical protein 0.0029 0.0154 0.0271
Schistosoma mansoni hypothetical protein 0.0446 0.3822 0.3822
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0274 0.7101
Echinococcus granulosus apoptotic protease activating factor 1 0.0033 0.0187 0.0176
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0061 0.0049
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0274 0.1744
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0027 0.0139 0.0243

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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