TDR Targets

Basic information

Technical information

TDR Targets ID: 879996
Name: N-(3-cyanophenyl)-2,3,5,6-tetramethylbenzenes ulfonamide
MW: 314.402 | Formula: C17H18N2O2S
H donors: 1 H acceptors: 3 LogP: 3.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cccc(c1)NS(=O)(=O)c1c(C)c(C)cc(c1C)C
InChi: 1S/C17H18N2O2S/c1-11-8-12(2)14(4)17(13(11)3)22(20,21)19-16-7-5-6-15(9-16)10-18/h5-9,19H,1-4H3
InChiKey: WMEKIOIJZOMRKT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3-cyanophenyl)-2,3,5,6-tetramethyl-benzenesulfonamide
ZINC06902936

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Retinal homeobox protein Rx homolog	0.0005	0.0025	0.0025
Echinococcus multilocularis	netrin receptor unc 5	0.0014	0.0217	0.0217
Onchocerca volvulus	Netrin receptor homolog	0.0014	0.0217	0.0217
Leishmania major	eukaryotic initiation factor 4a, putative	0.049	1	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1219	0.1219
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0664	0.0664
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0168	0.0168
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0241	0.0241
Mycobacterium ulcerans	cytochrome P450 123A3 Cyp123A3	0.003	0.0538	0.2721
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0168	0.0168
Onchocerca volvulus		0.0268	0.5445	0.5445
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0168	0.0168
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0246	0.0246
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0109	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0025	0.0025
Mycobacterium ulcerans	cytochrome P450 51B1 Cyp51B1	0.003	0.0538	0.2721
Mycobacterium leprae	Conserved hypothetical protein	0.003	0.0538	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.032	0.032
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0168	0.0168
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0168	0.0168
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0231	0.0231
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.032	0.032
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.003	0.0538	0.0538
Brugia malayi	Death domain containing protein	0.0014	0.0217	0.0217
Schistosoma mansoni	hypothetical protein	0.0424	0.8645	0.8645
Mycobacterium ulcerans	cytochrome P450 140A5 Cyp140A5	0.003	0.0538	0.2721
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0015	0.0231	0.0231
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.003	0.0538	0.0538
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0168	0.0168
Schistosoma mansoni	coup transcription factor	0.0012	0.0168	0.0168
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.032	0.032
Mycobacterium ulcerans	cytochrome P450 108B4 Cyp108B4	0.003	0.0538	0.2721
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0015	0.0231	0.0231
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0006	0.0037	0.0037
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0231	0.0231
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0246	0.0246
Mycobacterium ulcerans	cytochrome P450 136A2 Cyp136A2	0.003	0.0538	0.2721
Brugia malayi	hypothetical protein	0.0006	0.0037	0.0037
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0056	0.1071	0.1071
Mycobacterium ulcerans	cytochrome P450 191A3 Cyp191A3	0.003	0.0538	0.2721
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Schistosoma mansoni	ap endonuclease	0.0019	0.032	0.032
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.032	0.032
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.003	0.0538	0.0538
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0006	0.0037	0.0037
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0058	0.1121	1
Brugia malayi	hypothetical protein	0.0006	0.0037	0.0037
Plasmodium vivax	RNA helicase-1, putative	0.049	1	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.003	0.0538	0.0538
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.0246	0.0246
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0246	0.0246
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Leishmania major	cytochrome p450-like protein	0.0058	0.1121	0.1121
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0006	0.0037	0.0037
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0219	0.0219
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0246	0.0246
Loa Loa (eye worm)	cytochrome P450 family protein	0.0111	0.22	0.22
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Schistosoma mansoni	rab6-interacting	0.002	0.034	0.034
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.003	0.0538	0.0538
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.034	0.034
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0025	0.0025
Echinococcus granulosus	geminin	0.0171	0.3429	0.3429
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.049	1	1
Schistosoma mansoni	cytochrome P450	0.003	0.0538	0.0538
Brugia malayi	tailless protein	0.0006	0.0037	0.0037
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0006	0.0037	0.0037
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0058	0.0058
Mycobacterium ulcerans	cytochrome P450 187A4 Cyp187A4	0.003	0.0538	0.2721
Entamoeba histolytica	hypothetical protein	0.0036	0.0664	0.0664
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0664	0.0664
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.049	1	1
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.049	1	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0567	0.0567
Schistosoma mansoni	paired box protein pax-1-related	0.0005	0.0025	0.0025
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.034	0.034
Brugia malayi	nuclear receptor NHR-67	0.0006	0.0037	0.0037
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.032	0.032
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0037	0.0037
Echinococcus granulosus	RUN	0.002	0.034	0.034
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.1071	0.1071
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0006	0.0037	0.0037
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0056	0.1071	0.1071
Echinococcus multilocularis	Ankyrin	0.0015	0.0219	0.0219
Echinococcus granulosus	paired box protein pax 6	0.0005	0.0025	0.0025
Brugia malayi	Cytochrome P450 family protein	0.0111	0.22	0.22
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.1071	0.1071
Mycobacterium ulcerans	cytochrome P450 143A3 Cyp143A3	0.003	0.0538	0.2721
Loa Loa (eye worm)	hypothetical protein	0.049	1	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0025	0.0025
Trichomonas vaginalis	helicase, putative	0.0007	0.0058	0.0058
Onchocerca volvulus		0.002	0.034	0.034
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.1071	0.1071
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.0246	0.0246
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0051	0.0051
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.0015	0.0231	0.0231
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.032	0.032
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0246	0.0246
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0231	0.0231
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0227	0.0227
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0168	0.0168
Loa Loa (eye worm)	cytochrome P450	0.003	0.0538	0.0538
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0168	0.0168
Entamoeba histolytica	hypothetical protein	0.0036	0.0664	0.0664
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0058	0.0058
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0025	0.0025
Loa Loa (eye worm)	doublecortin family protein	0.002	0.034	0.034
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0231	0.0231
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0006	0.0037	0.0037
Brugia malayi	vab-3 gene.	0.0005	0.0025	0.0025
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0015	0.0231	0.5
Schistosoma mansoni	hypothetical protein	0.003	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.002	0.034	0.034
Mycobacterium ulcerans	cytochrome P450 144A4 Cyp144A4	0.003	0.0538	0.2721
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.003	0.0538	0.0538
Brugia malayi	hypothetical protein	0.0006	0.0051	0.0051
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.003	0.0538	0.0538
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0168	0.0168
Echinococcus multilocularis	RUN	0.002	0.034	0.034
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0168	0.0168
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0056	0.1071	0.1071
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0168	0.0168
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0058	0.0058
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.003	0.0538	0.0538
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.049	1	1
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.003	0.0538	0.0538
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0217	0.0217
Loa Loa (eye worm)	cytochrome P450 family protein	0.0058	0.1121	0.1121
Schistosoma mansoni	lipoxygenase	0.0057	0.1097	0.1097
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.032	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0168	0.0168
Echinococcus multilocularis	paired box protein pax 6	0.0005	0.0025	0.0025
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.049	1	1
Echinococcus multilocularis		0.003	0.0538	0.0538
Echinococcus granulosus	aryl hydrocarbon receptor	0.0015	0.0231	0.0231
Trypanosoma cruzi	cytochrome P450, putative	0.0058	0.1121	0.1121
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.003	0.0538	0.0538
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0106	0.0106
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.049	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0168	0.0168
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0016	0.0241	0.0241
Entamoeba histolytica	hypothetical protein	0.0036	0.0664	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Loa Loa (eye worm)	DR-78	0.0006	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0168	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Schistosoma mansoni	rab6-interacting	0.002	0.034	0.034
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.002	0.034	0.034
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0246	0.0246
Plasmodium falciparum	eukaryotic initiation factor 4A	0.049	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0168	0.0168
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0015	0.0231	0.0231
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0168	0.0168
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0056	0.1071	0.1071
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0056	0.1071	0.1071
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.032	0.032
Brugia malayi	Cytochrome P450 family protein	0.0058	0.1121	0.1121
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0058	0.0058
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.049	1	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0051	0.0051
Echinococcus multilocularis	paired box protein pax 1	0.0005	0.0025	0.0025
Schistosoma mansoni	zinc finger protein	0.0006	0.0037	0.0037
Echinococcus multilocularis	cpg binding protein	0.0031	0.0567	0.0567
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Toxoplasma gondii	exonuclease III APE	0.0019	0.032	0.032
Echinococcus granulosus	mitogen activated protein kinase 3	0.0056	0.1071	0.1071
Brugia malayi	paired box pox-meso protein	0.0005	0.0025	0.0025
Echinococcus multilocularis	paired box protein pax 6	0.0005	0.0025	0.0025
Schistosoma mansoni	paired box protein pax-6	0.0005	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0168	0.0168
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0006	0.0037	0.0037
Brugia malayi	hypothetical protein	0.0036	0.0664	0.0664
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.003	0.0538	0.0538
Entamoeba histolytica	hypothetical protein	0.0036	0.0664	0.0664
Schistosoma mansoni	cpg binding protein	0.003	0.0532	0.0532
Onchocerca volvulus		0.003	0.0532	0.0532
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.1071	0.1071
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0246	0.0246
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.049	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0006	0.0037	0.0037
Brugia malayi	hypothetical protein	0.0195	0.3943	0.3943
Schistosoma mansoni	single-minded	0.0058	0.1118	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0168	0.0168
Schistosoma mansoni	netrin receptor unc5	0.0014	0.0217	0.0217
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0051	0.0051
Brugia malayi	steroid hormone receptor	0.0012	0.0168	0.0168
Schistosoma mansoni	hypothetical protein	0.0171	0.3429	0.3429
Loa Loa (eye worm)	cytochrome P450 family protein	0.0058	0.1121	0.1121
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0246	0.0246
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0168	0.0168
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0006	0.0037	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0168	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.032	0.032
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.049	1	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0195	0.3943	0.3943
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0056	0.1071	0.1071
Brugia malayi	nuclear hormone receptor	0.0012	0.0168	0.0168
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0168	0.0168
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Echinococcus granulosus	cpg binding protein	0.0031	0.0567	0.0567
Loa Loa (eye worm)	paired box protein	0.0005	0.0025	0.0025
Leishmania major	protein kinase, putative	0.0016	0.0241	0.0241
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0058	0.0058
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0168	0.0168
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.032	0.032
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.0246	0.0246
Brugia malayi	nuclear hormone receptor family member odr-7	0.0006	0.0037	0.0037
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0664	0.0664
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0168	0.0168
Schistosoma mansoni	nuclear receptor	0.0006	0.0037	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0168	0.0168
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0168	0.0168
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.034	0.034
Mycobacterium ulcerans	cytochrome P450 187A5 Cyp187A5	0.003	0.0538	0.2721
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0168	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0015	0.0231	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0168	0.0168
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0006	0.0037	0.0037
Echinococcus multilocularis	geminin	0.0171	0.3429	0.3429
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0109	0.0109
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0168	0.0168
Trypanosoma brucei	Lanosterol 14-alpha demethylase	0.003	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.049	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0006	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0231	0.0231
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.108	0.108
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0058	0.0058
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0241	0.0241
Brugia malayi	Gooseberry protein	0.0005	0.0025	0.0025
Echinococcus multilocularis	dnaJ subfamily B	0.0424	0.8645	0.8645
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.034	0.034
Mycobacterium ulcerans	cytochrome P450 188A3 Cyp188A3	0.003	0.0538	0.2721
Giardia lamblia	Kinase, CMGC MAPK	0.0056	0.1071	0.1071
Brugia malayi	paired box protein	0.0005	0.0025	0.0025
Leishmania major	protein kinase, putative	0.0016	0.0241	0.0241
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.003	0.0538	0.0538
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.003	0.0538	0.0538
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.049	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0168	0.0168
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0051	0.0051
Brugia malayi	hypothetical protein	0.0006	0.0051	0.0051
Brugia malayi	hypoxia-induced factor 1	0.018	0.3631	0.3631
Brugia malayi	ecdysone receptor	0.0006	0.0037	0.0037
Leishmania major	cytochrome p450-like protein	0.003	0.0538	0.0538
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0168	0.0168
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.1097	0.1097
Onchocerca volvulus		0.0005	0.0025	0.0025
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0071	0.0071
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0168	0.0168
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.003	0.0538	0.0538
Mycobacterium ulcerans	cytochrome P450 126A3 Cyp126A3	0.003	0.0538	0.2721
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Onchocerca volvulus		0.0012	0.0168	0.0168
Mycobacterium ulcerans	cytochrome P450 189A7 Cyp189A7	0.003	0.0538	0.2721
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0109	0.0109
Treponema pallidum	ATP-dependent RNA helicase	0.049	1	1
Onchocerca volvulus		0.0006	0.0037	0.0037
Loa Loa (eye worm)	vab-3	0.0005	0.0025	0.0025
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0006	0.0037	0.0037
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0246	0.0246
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.049	1	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0006	0.0037	0.0037
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.049	1	1
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0246	0.0246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0168	0.0168
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0071	0.0071
Schistosoma mansoni	hypothetical protein	0.0014	0.0217	0.0217
Mycobacterium ulcerans	cytochrome P450 150A6 Cyp150A6	0.003	0.0538	0.2721
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0246	0.0246
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0168	0.0168
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.1071	0.1071
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0246	0.0246
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.032	0.032
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0014	0.0217	0.0217
Brugia malayi	Nuclear hormone receptor E75	0.0006	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0502	0.0502
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0016	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Brugia malayi	'Paired box' domain containing protein	0.0005	0.0025	0.0025
Brugia malayi	conserved hypotetical protein	0.0006	0.0037	0.0037
Mycobacterium ulcerans	cytochrome P450 124A1, Cyp124A1	0.003	0.0538	0.2721
Schistosoma mansoni	hypothetical protein	0.0036	0.0664	0.0664
Brugia malayi	PAS domain containing protein	0.0058	0.1118	0.1118
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.003	0.0538	0.0538
Schistosoma mansoni	ankyrin 23/unc44	0.0014	0.0217	0.0217
Brugia malayi	Cytochrome P450 family protein	0.0058	0.1121	0.1121
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Trypanosoma cruzi	cytochrome P450, putative	0.0058	0.1121	0.1121
Schistosoma mansoni	paired box protein pax-6	0.0005	0.0025	0.0025
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0168	0.0168
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0219	0.0219
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0222	0.4495	0.4495
Mycobacterium ulcerans	cytochrome P450 105Q4 Cyp105Q4	0.003	0.0538	0.2721
Schistosoma mansoni	paired box protein pax-6	0.0005	0.0025	0.0025
Brugia malayi	nuclear receptor NHR-88	0.0006	0.0037	0.0037
Brugia malayi	'Paired box' domain containing protein	0.0005	0.0025	0.0025
Echinococcus granulosus	thyroid hormone receptor alpha	0.0006	0.0037	0.0037
Echinococcus granulosus	dnaJ subfamily B	0.0424	0.8645	0.8645
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0168	0.0168
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0168	0.0168
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0056	0.1071	0.1071
Brugia malayi	Pax transcription factor protein 2	0.0268	0.5445	0.5445
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0014	0.0217	0.0217
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0231	0.0231
Brugia malayi	Cytochrome P450 family protein	0.003	0.0538	0.0538
Leishmania major	cytochrome p450-like protein	0.003	0.0538	0.0538
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0006	0.0037	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Echinococcus granulosus	mitogen activated protein kinase	0.0056	0.1071	0.1071
Onchocerca volvulus		0.0005	0.0025	0.0025
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0056	0.1071	0.1071
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.003	0.0538	0.0538
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.049	1	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0246	0.0246
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.0015	0.0231	0.0231
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0168	0.0168
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.003	0.0538	0.0538
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0014	0.0217	0.0217
Brugia malayi	nuclear receptor RXR	0.0006	0.0051	0.0051
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0168	0.0168
Mycobacterium ulcerans	cytochrome P450 142A3 Cyp142A3	0.003	0.0538	0.2721
Onchocerca volvulus		0.0043	0.0807	0.0807
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.034	0.034
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0006	0.0037	0.0037
Onchocerca volvulus		0.0015	0.0231	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Brugia malayi	ecdysteroid receptor	0.0012	0.0168	0.0168
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0007	0.0007
Echinococcus granulosus	nuclear receptor nhr 48	0.0006	0.0037	0.0037
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.032	0.032
Echinococcus granulosus	netrin receptor unc 5	0.0014	0.0217	0.0217
Onchocerca volvulus		0.002	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0168	0.0168
Trichomonas vaginalis	adenylate cyclase, type VII, putative	0.0015	0.0231	0.0231
Mycobacterium leprae	putative cytochrome p450	0.003	0.0538	1
Brugia malayi	'Paired box' domain containing protein	0.0005	0.0025	0.0025
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.032	0.032
Mycobacterium ulcerans	cytochrome p450 150 cyp150	0.003	0.0538	0.2721
Brugia malayi	Doublecortin family protein	0.002	0.034	0.034
Brugia malayi	hypothetical protein	0.002	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Trichomonas vaginalis	guanylate cyclase, putative	0.0015	0.0231	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0231	0.0231
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0071	0.0071
Echinococcus granulosus	single minded 2	0.0043	0.0807	0.0807
Loa Loa (eye worm)	CYP4Cod1	0.0058	0.1121	0.1121
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0168	0.0168
Echinococcus multilocularis	transfer RNA-Lys	0.0043	0.0807	0.0807
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0168	0.0168
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0231	0.0231
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.003	0.0538	0.0538
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0051	0.0051
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0168	0.0168
Onchocerca volvulus		0.0006	0.0037	0.0037
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.032	0.032
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Echinococcus granulosus	Ankyrin	0.0015	0.0219	0.0219
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0168	0.0168
Echinococcus granulosus	cytochrome P450 2K1	0.003	0.0538	0.0538
Echinococcus granulosus	paired box protein pax 6	0.0005	0.0025	0.0025
Trypanosoma brucei	cytochrome P450, putative	0.0058	0.1121	0.1121
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0168	0.0168
Brugia malayi	bHLH-PAS transcription factor	0.0043	0.0807	0.0807
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.003	0.0538	0.0538
Trichomonas vaginalis	adenylate cyclase, putative	0.0015	0.0231	0.0231
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0006	0.0037	0.0037
Schistosoma mansoni	hypothetical protein	0.002	0.034	0.034
Echinococcus granulosus	death domain containing protein	0.0014	0.0217	0.0217
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0006	0.0037	0.0037
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.003	0.0538	0.0538
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0014	0.0217	0.0217
Schistosoma mansoni	aryl hydrocarbon receptor	0.0058	0.1118	0.1118
Leishmania major	eukaryotic initiation factor 4a, putative	0.049	1	1
Loa Loa (eye worm)	hypoxia-induced factor 1	0.018	0.3631	0.3631
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0168	0.0168
Brugia malayi	MAP kinase sur-1	0.0056	0.1071	0.1071
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0071	0.0071
Trypanosoma brucei	protein kinase, putative	0.0056	0.1071	0.1071
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.003	0.0538	0.0538
Echinococcus multilocularis	mitogen activated protein kinase	0.0056	0.1071	0.1071
Schistosoma mansoni	hypothetical protein	0.0171	0.3429	0.3429
Toxoplasma gondii	cytochrome p450 superfamily protein	0.003	0.0538	0.0538
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.0246	0.0246
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0168	0.0168
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.003	0.0538	0.0538
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.049	1	1
Mycobacterium ulcerans	putative regulatory protein	0.0043	0.0807	0.6075
Brugia malayi	nuclear receptor RXR	0.0006	0.0037	0.0037
Brugia malayi	CXXC zinc finger family protein	0.003	0.0532	0.0532
Brugia malayi	Nuclear hormone receptor E75	0.0006	0.0037	0.0037
Mycobacterium ulcerans	cytochrome P450 125A7 Cyp125A7	0.003	0.0538	0.2721
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0168	0.0168
Schistosoma mansoni	cpg binding protein	0.0031	0.0567	0.0567
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.032	0.032
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0168	0.0168
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0051	0.0051
Loa Loa (eye worm)	pax transcription factor protein 2	0.0268	0.5445	0.5445
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.034	0.034
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.034	0.034
Schistosoma mansoni	nuclear receptor nhr-48	0.0006	0.0037	0.0037
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0532	0.0532
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Schistosoma mansoni	nuclear receptor	0.0006	0.0037	0.0037
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0006	0.0037	0.0037
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0168	0.0168
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0058	0.0058
Brugia malayi	hypothetical protein	0.002	0.034	0.034
Echinococcus multilocularis	paired box protein pax 6	0.0005	0.0025	0.0025
Schistosoma mansoni	nuclear hormone receptor	0.0006	0.0037	0.0037
Trichomonas vaginalis	CMGC family protein kinase	0.0056	0.1071	0.1071
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.003	0.0538	0.0538
Brugia malayi	cytochrome P450	0.003	0.0538	0.0538
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.1097	0.1097
Brugia malayi	nuclear hormone receptor	0.0006	0.0037	0.0037
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0231	0.0231
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0168	0.0168
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0246	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Mycobacterium ulcerans	cytochrome P450 143A4 Cyp143A4	0.003	0.0538	0.2721
Echinococcus granulosus	eukaryotic initiation factor 4A	0.049	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0168	0.0168
Echinococcus granulosus	paired box protein pax 1	0.0005	0.0025	0.0025
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.0246	0.0246
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0006	0.0037	0.0037
Schistosoma mansoni	loxhd1	0.002	0.034	0.034
Schistosoma mansoni	polycystin 1-related	0.002	0.034	0.034
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Echinococcus multilocularis	nuclear receptor nhr 48	0.0006	0.0037	0.0037
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0222	0.4495	0.4495
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.049	1	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0056	0.1071	0.1071
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0037	0.0037
Schistosoma mansoni	lipoxygenase	0.002	0.034	0.034
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0168	0.0168
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.003	0.0538	0.0538
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0015	0.0231	0.0231
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0051	0.0051
Brugia malayi	Uncoordinated protein 44	0.0014	0.0217	0.0217
Echinococcus granulosus	paired box gene 3/7 (eyeless, eyegone, twin of eyeless)	0.0005	0.0025	0.0025
Schistosoma mansoni	ap endonuclease	0.0019	0.032	0.032

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 879996