Detailed information for compound 883321

Basic information

Technical information
  • TDR Targets ID: 883321
  • Name: [4-[4-[(E)-[(3-hydroxynaphthalene-2-carbonyl) hydrazinylidene]methyl]phenyl]phenyl] acetate
  • MW: 424.448 | Formula: C26H20N2O4
  • H donors: 2 H acceptors: 3 LogP: 5.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1ccc(cc1)c1ccc(cc1)C=NNC(=O)c1cc2ccccc2cc1O
  • InChi: 1S/C26H20N2O4/c1-17(29)32-23-12-10-20(11-13-23)19-8-6-18(7-9-19)16-27-28-26(31)24-14-21-4-2-3-5-22(21)15-25(24)30/h2-16,30H,1H3,(H,28,31)/b27-16+
  • InChiKey: KQMSGQPDSXAIPW-JVWAILMASA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[4-[[(3-hydroxynaphthalene-2-carbonyl)hydrazinylidene]methyl]phenyl]phenyl] acetate
  • [4-[4-[(E)-[(3-hydroxynaphthalene-2-carbonyl)hydrazono]methyl]phenyl]phenyl] acetate
  • [4-[4-[[(3-hydroxynaphthalene-2-carbonyl)hydrazono]methyl]phenyl]phenyl] acetate
  • acetic acid [4-[4-[(E)-[[(3-hydroxy-2-naphthyl)-oxomethyl]hydrazono]methyl]phenyl]phenyl] ester
  • acetic acid [4-[4-[[[(3-hydroxy-2-naphthyl)-oxomethyl]hydrazono]methyl]phenyl]phenyl] ester
  • acetic acid [4-[4-[[(3-hydroxynaphthalene-2-carbonyl)hydrazono]methyl]phenyl]phenyl] ester
  • acetic acid [4-[4-[(E)-[(3-hydroxynaphthalene-2-carbonyl)hydrazono]methyl]phenyl]phenyl] ester
  • [4-[4-[[(3-hydroxynaphthalen-2-yl)carbonylhydrazinylidene]methyl]phenyl]phenyl] ethanoate
  • [4-[4-[(E)-[(3-hydroxynaphthalen-2-yl)carbonylhydrazinylidene]methyl]phenyl]phenyl] ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0065 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0213 0.209 0.2401
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0339 0.0355
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Loa Loa (eye worm) cytochrome P450 0.0047 0.0266 0.0339
Brugia malayi hypothetical protein 0.0064 0.0451 0.0597
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0213 0.209 0.2949
Echinococcus multilocularis aryl hydrocarbon receptor 0.0028 0.0051 0.0019
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Mycobacterium ulcerans putative regulatory protein 0.0079 0.0611 0.0355
Echinococcus granulosus single minded 2 0.0082 0.0649 0.0717
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0213 0.209 0.2954
Onchocerca volvulus 0.0145 0.1338 0.442
Schistosoma mansoni tyrosinase precursor 0.0091 0.0745 0.083
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.09 0.1249
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0339 0.0355
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0112 0.0985 0.111
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Echinococcus multilocularis Nuclear hormone receptor HR96 0.01 0.0853 0.0956
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0215 0.0702
Brugia malayi excitatory GABA receptor EXP-1A 0.0139 0.1271 0.1774
Echinococcus granulosus Nuclear hormone receptor HR96 0.01 0.0853 0.0956
Onchocerca volvulus 0.0139 0.1271 0.4192
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0047 0.0266 0.0687
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0466 0.4872 0.6944
Loa Loa (eye worm) hypothetical protein 0.0112 0.0985 0.1371
Echinococcus granulosus ecdysone induced protein 78C 0.0213 0.209 0.2401
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Onchocerca volvulus Peroxidasin homolog 0.0105 0.09 0.2934
Brugia malayi ecdysteroid receptor 0.0213 0.209 0.2949
Brugia malayi Pre-SET motif family protein 0.0201 0.1959 0.2761
Echinococcus granulosus geminin 0.0357 0.3675 0.4253
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0349 0.0451
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.1201 0.1674
Brugia malayi Animal haem peroxidase family protein 0.0105 0.09 0.1242
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0088 0.0711 0.0971
Brugia malayi cytochrome P450 0.0047 0.0266 0.0331
Loa Loa (eye worm) hypothetical protein 0.0091 0.0745 0.1026
Trichomonas vaginalis adenylate cyclase, putative 0.0028 0.0051 0.0227
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.209 0.2401
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1271 0.1774
Brugia malayi Animal haem peroxidase family protein 0.0105 0.09 0.1242
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0266 0.0865
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.09 0.1249
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Loa Loa (eye worm) hypothetical protein 0.0055 0.0349 0.0458
Leishmania major cytochrome p450-like protein 0.0047 0.0266 0.0865
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0213 0.209 0.2949
Entamoeba histolytica hypothetical protein 0.011 0.0953 1
Schistosoma mansoni survival motor neuron protein 0.0105 0.0901 0.1013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0213 0.209 0.2954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0213 0.209 0.2954
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0054 0.0339 0.0355
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0451 0.0597
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0064 0.0451 0.0604
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Echinococcus multilocularis FTZ F1 alpha 0.0213 0.209 0.2401
Echinococcus granulosus jun protein 0.0375 0.3869 0.448
Loa Loa (eye worm) carbonic anhydrase 3 0.024 0.2384 0.3376
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Echinococcus granulosus peroxidasin 0.0105 0.09 0.1011
Brugia malayi Nuclear hormone receptor-like 1 0.0213 0.209 0.2949
Echinococcus granulosus carbonic anhydrase 0.0055 0.0349 0.0367
Onchocerca volvulus 0.01 0.0853 0.2773
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0213 0.209 0.2401
Echinococcus multilocularis glycine receptor subunit beta 0.0139 0.1271 0.1444
Loa Loa (eye worm) solute carrier family 6 member 4 0.0088 0.0711 0.0978
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0118 0.1042 0.3392
Brugia malayi Animal haem peroxidase family protein 0.0105 0.09 0.1242
Loa Loa (eye worm) nuclear receptor nhr-7B 0.01 0.0853 0.1181
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Brugia malayi Animal haem peroxidase family protein 0.0105 0.09 0.1242
Brugia malayi hypothetical protein 0.01 0.0853 0.1174
Echinococcus granulosus carbonic anhydrase II 0.024 0.2384 0.2745
Schistosoma mansoni netrin receptor unc5 0.005 0.03 0.031
Toxoplasma gondii cytochrome p450 superfamily protein 0.0047 0.0266 0.7124
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1042 0.0797
Leishmania major cytochrome p450-like protein 0.0056 0.0363 0.1181
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1033 0.144
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0572 0.1862
Brugia malayi Nuclear hormone receptor-like 1 0.0112 0.0985 0.1364
Brugia malayi nuclear receptor RXR 0.0112 0.0985 0.1364
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1271 0.1774
Schistosoma mansoni nuclear receptor 0.01 0.0853 0.0956
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0028 0.0051 0.0227
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0128
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Echinococcus granulosus fatty acid amide hydrolase 1 0.0098 0.0831 0.093
Trypanosoma cruzi cruzipain precursor, putative 0.0075 0.0572 0.1862
Brugia malayi nuclear hormone receptor family member odr-7 0.01 0.0853 0.1174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0054 0.0339 0.0355
Onchocerca volvulus 0.0091 0.0745 0.2408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Echinococcus granulosus cytochrome P450 2K1 0.0047 0.0266 0.027
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0112 0.0985 0.111
Schistosoma mansoni acetylcholine receptor subunit beta 0.0064 0.0451 0.0486
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.005 0.03 0.031
Brugia malayi hypothetical protein 0.0112 0.0985 0.1364
Loa Loa (eye worm) doublecortin family protein 0.0145 0.1338 0.1877
Echinococcus granulosus survival motor neuron protein 1 0.0514 0.5402 0.6271
Brugia malayi nuclear hormone receptor 0.0213 0.209 0.2949
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0451 0.0597
Schistosoma mansoni RAR-like nuclear receptor 0.0213 0.209 0.2401
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.1201 0.168
Loa Loa (eye worm) TAR-binding protein 0.0132 0.1201 0.168
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0118 0.1042 0.0797
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0349 0.0451
Brugia malayi hypothetical protein 0.0145 0.1338 0.1871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.209 0.2401
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1271 0.1444
Onchocerca volvulus Protein ultraspiracle homolog 0.0213 0.209 0.6967
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Onchocerca volvulus 0.0145 0.1338 0.442
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1321 0.419
Echinococcus multilocularis lipoxygenase domain containing protein 0.0145 0.1338 0.1523
Brugia malayi amidase 0.0098 0.0831 0.1143
Onchocerca volvulus 0.0229 0.2269 0.7575
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0213 0.209 0.2401
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.01 0.0853 0.0956
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0051 0.0167
Onchocerca volvulus 0.0064 0.0451 0.141
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Brugia malayi hypothetical protein 0.0356 0.3661 0.5204
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0349 0.0367
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0375 0.3869 0.448
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Brugia malayi Cation transporter family protein 0.0139 0.1271 0.1774
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0213 0.209 0.2401
Trypanosoma brucei cytochrome P450, putative 0.0056 0.0363 0.1009
Schistosoma mansoni nuclear hormone receptor 0.01 0.0853 0.0956
Schistosoma mansoni ankyrin 23/unc44 0.005 0.03 0.031
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0215 0.052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1271 0.1774
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0569 0.0766
Brugia malayi Putative carbonic anhydrase 5 precursor 0.024 0.2384 0.3371
Brugia malayi nuclear receptor RXR 0.01 0.0853 0.1174
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0035 0.0008
Leishmania major carbonic anhydrase-like protein 0.024 0.2384 0.7763
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0154 0.0139
Loa Loa (eye worm) blistered cuticle protein 3 0.0105 0.09 0.1249
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0349 0.0367
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0139 0.1271 0.1774
Brugia malayi bZIP transcription factor family protein 0.0375 0.3869 0.5503
Brugia malayi Peroxidasin 0.0105 0.09 0.1242
Loa Loa (eye worm) serotonin transporter b 0.0088 0.0711 0.0978
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0339 0.0355
Loa Loa (eye worm) hypothetical protein 0.0514 0.5402 0.7705
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Schistosoma mansoni amidase 0.0098 0.0831 0.093
Schistosoma mansoni nAChR subunit 0.0064 0.0451 0.0486
Loa Loa (eye worm) hypothetical protein 0.005 0.03 0.0388
Entamoeba histolytica hypothetical protein 0.011 0.0953 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1201 0.1363
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.005 0.03 0.0388
Brugia malayi Importin beta-1 subunit 0.0028 0.0059 0.0034
Loa Loa (eye worm) acetylcholine receptor protein 0.0064 0.0451 0.0604
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0098 0.0831 0.093
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Onchocerca volvulus 0.0139 0.1271 0.4192
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1271 0.1444
Onchocerca volvulus 0.0105 0.09 0.2934
Brugia malayi PAS domain containing protein 0.0106 0.0914 0.1263
Brugia malayi Immunoglobulin I-set domain containing protein 0.005 0.03 0.0381
Echinococcus multilocularis glycine receptor subunit beta 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.0078 0.0603 0.0822
Trichomonas vaginalis set domain proteins, putative 0.0229 0.2264 1
Echinococcus granulosus snurportin 1 0.0301 0.3062 0.3537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0144 0.0157
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Toxoplasma gondii hypothetical protein 0.0049 0.0284 0.7763
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0051 0.0167
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1271 0.1444
Onchocerca volvulus Peroxidasin homolog 0.0105 0.09 0.2934
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0139 0.1271 0.1444
Brugia malayi orphan nuclear receptor NR2E1 0.01 0.0853 0.1174
Echinococcus multilocularis RUN 0.0145 0.1338 0.1523
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0139 0.1271 0.1444
Onchocerca volvulus 0.0105 0.0901 0.2939
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0349 0.0367
Brugia malayi ecdysone receptor 0.01 0.0853 0.1174
Schistosoma mansoni hypothetical protein 0.0305 0.3097 0.3578
Onchocerca volvulus 0.0075 0.0569 0.181
Echinococcus granulosus importin subunit beta 1 0.0028 0.0059 0.0028
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.01 0.0853 0.2773
Onchocerca volvulus 0.0213 0.209 0.6967
Schistosoma mansoni hypothetical protein 0.0055 0.0349 0.0367
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.024 0.2384 0.3371
Schistosoma mansoni fatty-acid amide hydrolase 0.0098 0.0831 0.093
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0112 0.0985 0.111
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0139 0.1271 0.1444
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0055 0.0349 0.0451
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0028 0.0051 0.0019
Onchocerca volvulus 0.01 0.0853 0.2773
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0051 0.0227
Schistosoma mansoni neurotransmitter gated ion channel 0.0075 0.0569 0.0624
Onchocerca volvulus 0.0079 0.0611 0.1955
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0028 0.0051 0.0167
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Brugia malayi photoreceptor-specific nuclear receptor 0.0213 0.209 0.2949
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0365 0.3756 0.5344
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0139 0.1271 0.1444
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0318 0.1034
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0213 0.209 0.2949
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0139 0.1271 0.1444
Brugia malayi Blistered cuticle protein 3 0.0105 0.09 0.1242
Echinococcus granulosus Nuclear hormone receptor HR96 0.01 0.0853 0.0956
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0215 0.0702
Brugia malayi Uncoordinated protein 44 0.005 0.03 0.0381
Schistosoma mansoni rab6-interacting 0.0145 0.1338 0.1523
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0139 0.1271 0.1781
Echinococcus multilocularis carbonic anhydrase II 0.024 0.2384 0.2745
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0213 0.209 0.2949
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Schistosoma mansoni lipoxygenase 0.0544 0.5731 0.6656
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.05 0.1629
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.01 0.0853 0.1174
Schistosoma mansoni zinc finger protein 0.01 0.0853 0.0956
Brugia malayi hypothetical protein 0.0064 0.0451 0.0597
Brugia malayi Doublecortin family protein 0.0145 0.1338 0.1871
Echinococcus multilocularis survival motor neuron protein 1 0.0514 0.5402 0.6271
Brugia malayi follicle stimulating hormone receptor 0.0466 0.4872 0.6942
Brugia malayi nuclear receptor NHR-67 0.01 0.0853 0.1174
Brugia malayi Death domain containing protein 0.005 0.03 0.0381
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0411 0.4264 0.4941
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0106 0.0916 0.1272
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0064 0.0451 0.0597
Loa Loa (eye worm) hypothetical protein 0.0545 0.5742 0.8193
Brugia malayi hypothetical protein 0.0145 0.1338 0.1871
Brugia malayi MH2 domain containing protein 0.0117 0.1033 0.1433
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0213 0.209 0.2949
Echinococcus granulosus Polycystic kidney disease protein 0.0145 0.1338 0.1523
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.3071 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0213 0.209 0.2954
Onchocerca volvulus 0.0091 0.0745 0.2408
Plasmodium vivax multidomain scavenger receptor, putative 0.0145 0.1338 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0051 0.0227
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0075 0.0569 0.0624
Loa Loa (eye worm) hypothetical protein 0.0029 0.0065 0.0051
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0139 0.1271 0.1781
Onchocerca volvulus Chorion peroxidase homolog 0.0105 0.09 0.2934
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0047 0.0266 0.0865
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1271 0.1774
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1271 0.1444
Schistosoma mansoni hypothetical protein 0.011 0.0953 0.1073
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0363 0.1181
Loa Loa (eye worm) hypothetical protein 0.0028 0.0059 0.0042
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0051 0.0167
Onchocerca volvulus Bile acid receptor homolog 0.0213 0.209 0.6967
Echinococcus multilocularis peroxidasin 0.0105 0.09 0.1011
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0506 0.5306 0.6159
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0059 0.0028
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0745 0.1019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0213 0.209 0.2954
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0213 0.209 0.6967
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0932 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0213 0.209 0.2401
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0139 0.1271 0.1444
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0213 0.209 0.2949
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0213 0.209 0.2401
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0064 0.0451 0.0597
Brugia malayi Cation transporter family protein 0.0139 0.1271 0.1774
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0451 0.0486
Leishmania major cytochrome p450-like protein 0.0047 0.0266 0.0865
Brugia malayi Nuclear hormone receptor-like 1 0.0112 0.0985 0.1364
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.0363 0.1181
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Echinococcus multilocularis Nuclear hormone receptor HR96 0.01 0.0853 0.0956
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0051 0.0227
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0745 0.1026
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Brugia malayi hypoxia-induced factor 1 0.0328 0.3358 0.4769
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0064 0.0451 0.0597
Onchocerca volvulus Netrin receptor homolog 0.005 0.03 0.0899
Loa Loa (eye worm) norepinephrine transporter 0.0088 0.0711 0.0978
Echinococcus multilocularis nAChR subunit 0.0075 0.0569 0.0624
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0349 0.0367
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0349 0.0451
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3071 1
Echinococcus multilocularis geminin 0.0357 0.3675 0.4253
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0213 0.209 0.2401
Echinococcus multilocularis lipoxygenase domain containing protein 0.0145 0.1338 0.1523
Toxoplasma gondii hypothetical protein 0.0055 0.0349 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1271 0.1444
Onchocerca volvulus 0.0028 0.0051 0.0056
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0523 0.5501 0.6387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0144 0.0164
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0064 0.0451 0.0486
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0064 0.0451 0.0486
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.0609 0.6445 0.92
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0075 0.0569 0.0766
Schistosoma mansoni neurotransmitter gated ion channel 0.0064 0.0451 0.0486
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0139 0.1271 0.1444
Onchocerca volvulus 0.0105 0.09 0.2934
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0998 0.1383
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0213 0.209 0.2401
Treponema pallidum sodium- and chloride- dependent transporter 0.0088 0.0711 0.5
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0035 0.0008
Echinococcus granulosus aryl hydrocarbon receptor 0.0028 0.0051 0.0019
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.024 0.2384 0.2745
Mycobacterium ulcerans proteasome PrcA 0.0932 1 1
Leishmania major protein kinase, putative 0.0028 0.0051 0.0167
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0118 0.1042 0.1176
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0088 0.0711 0.0791
Echinococcus multilocularis serotonin transporter 0.0088 0.0711 0.0791
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0112 0.0985 0.111
Echinococcus multilocularis nAChR subunit 0.0139 0.1271 0.1444
Entamoeba histolytica hypothetical protein 0.011 0.0953 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0213 0.209 0.2949
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0128
Schistosoma mansoni hypothetical protein 0.0301 0.3062 0.3537
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Brugia malayi tailless protein 0.01 0.0853 0.1174
Schistosoma mansoni aryl hydrocarbon receptor 0.0106 0.0914 0.1028
Schistosoma mansoni thyroid hormone receptor 0.0213 0.209 0.2401
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0051 0.0227
Leishmania major cathepsin L-like protease 0.0075 0.0572 0.1862
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0213 0.209 0.2401
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Onchocerca volvulus 0.0091 0.0745 0.2408
Brugia malayi Cation transporter family protein 0.0139 0.1271 0.1774
Loa Loa (eye worm) hypothetical protein 0.0435 0.4529 0.6452
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0144 0.0128
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.09 0.1249
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0191 0.0183
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0118 0.1042 0.0797
Echinococcus multilocularis nuclear receptor nhr 48 0.01 0.0853 0.0956
Loa Loa (eye worm) hypothetical protein 0.0036 0.0144 0.0164
Brugia malayi Serotonin receptor 0.0457 0.477 0.6796
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0213 0.209 0.2949
Mycobacterium leprae putative cytochrome p450 0.0047 0.0266 0.0215
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0572 0.1862
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0213 0.209 0.2954
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Onchocerca volvulus 0.0294 0.2984 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0213 0.209 0.2401
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0213 0.209 0.2401
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0098 0.0831 0.093
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1201 0.1363
Brugia malayi bHLH-PAS transcription factor 0.0079 0.0611 0.0828
Schistosoma mansoni hypothetical protein 0.005 0.03 0.031
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3062 0.4349
Brugia malayi hypothetical protein 0.011 0.0953 0.1319
Leishmania major protein kinase, putative 0.0032 0.0105 0.0342
Schistosoma mansoni carbonic anhydrase 0.0055 0.0349 0.0367
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.0901 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0213 0.209 0.2949
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0028 0.0051 0.0227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0998 0.1383
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0257 0.2574 0.2967
Echinococcus granulosus FTZ F1 alpha 0.0213 0.209 0.2401
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Loa Loa (eye worm) hypothetical protein 0.0051 0.0305 0.0395
Loa Loa (eye worm) hypothetical protein 0.0032 0.01 0.0102
Brugia malayi Cytochrome P450 family protein 0.0206 0.2013 0.284
Schistosoma mansoni carbonic anhydrase-related 0.0055 0.0349 0.0367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0339 0.0355
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0215 0.0702
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Schistosoma mansoni nuclear receptor 0.01 0.0853 0.0956
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0055 0.0349 0.0458
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.3071 1
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Brugia malayi TAR-binding protein 0.0132 0.1201 0.1674
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.1959 0.2767
Brugia malayi steroid hormone receptor 0.0213 0.209 0.2949
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0054 0.0022
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0065 0.0036
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0213 0.209 0.2401
Loa Loa (eye worm) hypothetical protein 0.0091 0.0745 0.1026
Schistosoma mansoni cytochrome P450 0.0047 0.0266 0.027
Plasmodium falciparum carbonic anhydrase 0.0055 0.0349 0.227
Brugia malayi Nuclear hormone receptor E75 0.01 0.0853 0.1174
Brugia malayi RNA binding protein 0.0132 0.1201 0.1674
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0213 0.209 0.2949
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0028 0.0051 0.0031
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0118 0.1042 0.1445
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Echinococcus granulosus Ankyrin 0.0051 0.0305 0.0315
Plasmodium falciparum LCCL domain-containing protein 0.0145 0.1338 1
Brugia malayi Animal haem peroxidase family protein 0.0105 0.09 0.1242
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0047 0.0266 0.0865
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1271 0.1774
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0028 0.0051 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0363 0.0478
Loa Loa (eye worm) cytochrome P450 family protein 0.0206 0.2013 0.2845
Schistosoma mansoni acetylcholine receptor-related 0.0064 0.0451 0.0486
Echinococcus multilocularis conserved hypothetical protein 0.0667 0.7078 0.8229
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0031
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0051 0.0227
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0609 0.6445 0.92
Schistosoma mansoni rab6-interacting 0.0145 0.1338 0.1523
Echinococcus granulosus thyroid hormone receptor alpha 0.01 0.0853 0.0956
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0213 0.209 0.2401
Onchocerca volvulus 0.0139 0.1271 0.4192
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0065 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0213 0.209 0.2949
Loa Loa (eye worm) animal heme peroxidase 0.0105 0.09 0.1249
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1271 0.1774
Schistosoma mansoni loxhd1 0.0145 0.1338 0.1523
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Brugia malayi hypothetical protein 0.0112 0.0985 0.1364
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0191 0.0183
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0144 0.0157
Brugia malayi hypothetical protein 0.0064 0.0451 0.0597
Leishmania major cathepsin L-like protease 0.0075 0.0572 0.1862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Schistosoma mansoni peroxidasin 0.0105 0.09 0.1011
Schistosoma mansoni lipoxygenase 0.0805 0.8594 1
Echinococcus granulosus death domain containing protein 0.005 0.03 0.031
Schistosoma mansoni coup transcription factor 0.0213 0.209 0.2401
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0603 0.0815
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Echinococcus granulosus glycine receptor subunit beta 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Onchocerca volvulus Putative nachr subunit 0.0139 0.1271 0.4192
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0065 0.0036
Loa Loa (eye worm) steroid hormone receptor 0.0213 0.209 0.2954
Brugia malayi hypothetical protein 0.0105 0.09 0.1242
Brugia malayi hypothetical protein 0.0064 0.0451 0.0597
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0953 0.1073
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1271 0.1444
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1201 0.1363
Schistosoma mansoni hypothetical protein 0.0357 0.3675 0.4253
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0139 0.1271 0.1774
Loa Loa (eye worm) hypothetical protein 0.0088 0.0711 0.0978
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0154 0.0139
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0745 0.1019
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0075 0.0569 0.0624
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1271 0.1774
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0144 0.0128
Echinococcus granulosus netrin receptor unc 5 0.005 0.03 0.031
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Echinococcus granulosus serotonin transporter 0.0088 0.0711 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0112 0.0985 0.1371
Echinococcus granulosus nuclear receptor nhr 48 0.01 0.0853 0.0956
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0075 0.0569 0.0766
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0028 0.0051 0.0167
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0213 0.209 0.2949
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.01 0.0853 0.2773
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0055 0.0349 0.0451
Brugia malayi hypothetical protein 0.0294 0.2984 0.4233
Loa Loa (eye worm) GABA receptor subunit 0.0075 0.0569 0.0773
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Entamoeba histolytica hypothetical protein 0.011 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0139 0.1271 0.1444
Echinococcus granulosus GPCR family 2 0.0036 0.0144 0.0128
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.01 0.0853 0.0956
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0139 0.1271 0.1774
Loa Loa (eye worm) ACC-1 protein 0.0139 0.1271 0.1781
Echinococcus multilocularis netrin receptor unc 5 0.005 0.03 0.031
Loa Loa (eye worm) nuclear hormone receptor 0.01 0.0853 0.1181
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0128
Echinococcus granulosus hypothetical protein 0.0679 0.7213 0.8387
Echinococcus multilocularis 0.0047 0.0266 0.027
Brugia malayi nuclear receptor NHR-88 0.01 0.0853 0.1174
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0051 0.0227
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.0363 0.01
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.01 0.0853 0.0956
Loa Loa (eye worm) ShTK domain-containing protein 0.0091 0.0745 0.1026
Echinococcus multilocularis thyroid hormone receptor alpha 0.0213 0.209 0.2401
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0064 0.0451 0.0486
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0375 0.3869 0.448
Echinococcus multilocularis transfer RNA-Lys 0.0079 0.0611 0.0674
Trypanosoma brucei carbonic anhydrase-like protein 0.024 0.2384 0.772
Brugia malayi Cytochrome P450 family protein 0.0056 0.0363 0.047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.01 0.0853 0.0956
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0139 0.1271 0.1444
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0065 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0213 0.209 0.2954
Schistosoma mansoni importin beta-1 0.0028 0.0059 0.0028
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1201 0.1363
Onchocerca volvulus 0.0088 0.0711 0.2294
Loa Loa (eye worm) hypothetical protein 0.0112 0.0985 0.1371
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.024 0.2384 0.2745
Onchocerca volvulus 0.0139 0.1271 0.4192
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0144 0.0128
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0051 0.0167
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1498 0.1266
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0139 0.1271 0.1444
Schistosoma mansoni nuclear receptor nhr-48 0.01 0.0853 0.0956
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0139 0.1271 0.1444
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.024 0.2384 0.7763
Loa Loa (eye worm) hypothetical protein 0.0075 0.0569 0.0773
Brugia malayi hypothetical protein 0.0514 0.5402 0.7703
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0805 0.8594 1
Schistosoma mansoni retinoic acid receptor RXR 0.0523 0.5501 0.6387
Loa Loa (eye worm) ACC-1 protein 0.0139 0.1271 0.1781
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0139 0.1271 0.1444
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.024 0.2384 0.3376
Loa Loa (eye worm) hypothetical protein 0.0055 0.0349 0.0458
Echinococcus multilocularis carbonic anhydrase 0.0055 0.0349 0.0367
Loa Loa (eye worm) hypothetical protein 0.0088 0.0711 0.0978
Loa Loa (eye worm) hypothetical protein 0.0145 0.1338 0.1877
Echinococcus granulosus carbonic anhydrase 0.0055 0.0349 0.0367
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0065 0.0036
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0028 0.0051 0.0019
Loa Loa (eye worm) LGC-31 protein 0.0139 0.1271 0.1781
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0139 0.1271 0.1444
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0213 0.209 0.2401
Loa Loa (eye worm) hypoxia-induced factor 1 0.0328 0.3358 0.4773
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0127 0.0563
Schistosoma mansoni nAChR subunit 0.0064 0.0451 0.0486
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0064 0.0451 0.0604
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0091 0.0745 0.1019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0213 0.209 0.2401
Brugia malayi hypothetical protein 0.0064 0.0451 0.0597
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1042 0.1176
Schistosoma mansoni nuclear hormone receptor 0.01 0.0853 0.0956
Echinococcus multilocularis snurportin 1 0.0301 0.3062 0.3537
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0054 0.0339 0.0436
Echinococcus multilocularis Ankyrin 0.0051 0.0305 0.0315
Echinococcus granulosus fatty acid amide hydrolase 1 0.0098 0.0831 0.093
Mycobacterium ulcerans hypothetical protein 0.0159 0.1498 0.1266
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.0112 0.0985 0.1371
Schistosoma mansoni hypothetical protein 0.0357 0.3675 0.4253
Schistosoma mansoni hypothetical protein 0.0105 0.0901 0.1013
Brugia malayi Cytochrome P450 family protein 0.0056 0.0363 0.047
Onchocerca volvulus 0.0064 0.0451 0.141
Brugia malayi RNA, U transporter 1 0.008 0.0631 0.0856
Schistosoma mansoni thyroid hormone receptor 0.0213 0.209 0.2401
Loa Loa (eye worm) hypothetical protein 0.0055 0.0349 0.0458
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0805 0.8594 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0118 0.1042 0.1176
Echinococcus granulosus glycine receptor subunit alpha 1 0.0139 0.1271 0.1444
Trichomonas vaginalis guanylate cyclase, putative 0.0028 0.0051 0.0227
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0953 0.1073
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.0105 0.09 0.1249
Echinococcus multilocularis ecdysone induced protein 78C 0.0213 0.209 0.2401
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0139 0.1271 0.1444
Onchocerca volvulus 0.0029 0.0065 0.0104
Brugia malayi conserved hypotetical protein 0.01 0.0853 0.1174
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Schistosoma mansoni hypothetical protein 0.0047 0.0266 0.027
Brugia malayi hypothetical protein 0.01 0.0853 0.1174
Brugia malayi ShTK domain containing protein 0.0091 0.0745 0.1019
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0139 0.1271 0.1774
Echinococcus granulosus nuclear receptor 2DBD gamma 0.01 0.0853 0.0956
Loa Loa (eye worm) hypothetical protein 0.0114 0.0998 0.139
Onchocerca volvulus 0.0064 0.0451 0.141
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0075 0.0569 0.0766
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0139 0.1271 0.1444
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0139 0.1271 0.1781
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0028 0.0051 0.0167
Brugia malayi nuclear receptor NHR-88 0.0213 0.209 0.2949
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0154 0.0171
Trypanosoma cruzi major cysteine proteinase, putative 0.0059 0.0396 0.1288
Echinococcus granulosus lipoxygenase domain containing protein 0.0145 0.1338 0.1523
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0008
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Echinococcus granulosus carbonic anhydrase 0.0055 0.0349 0.0367
Brugia malayi Common central domain of tyrosinase family protein 0.0091 0.0745 0.1019
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0028 0.0051 0.0227
Loa Loa (eye worm) hypothetical protein 0.0213 0.209 0.2954
Echinococcus granulosus glycine receptor subunit beta 0.0139 0.1271 0.1444
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Brugia malayi small heat shock protein 0.066 0.7002 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0154 0.0179
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Echinococcus multilocularis Polycystic kidney disease protein 0.0145 0.1338 0.1523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0054 0.0339 0.0355
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0998 0.139
Onchocerca volvulus 0.0105 0.09 0.2934
Schistosoma mansoni sodium/chloride dependent transporter 0.0088 0.0711 0.0791
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0075 0.0572 0.1703
Schistosoma mansoni peroxidasin 0.0105 0.09 0.1011
Echinococcus granulosus nAChR subunit 0.0139 0.1271 0.1444
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.3071 1
Brugia malayi Steroid receptor seven-up type 2 0.0213 0.209 0.2949
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0065 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0132 0.1201 0.1363
Entamoeba histolytica hypothetical protein 0.0075 0.0569 0.5964
Mycobacterium leprae Conserved hypothetical protein 0.0047 0.0266 0.0215
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0139 0.1271 0.1444
Echinococcus granulosus RUN 0.0145 0.1338 0.1523
Echinococcus granulosus lipoxygenase domain containing protein 0.0145 0.1338 0.1523
Echinococcus granulosus tar DNA binding protein 0.0132 0.1201 0.1363
Schistosoma mansoni nuclear hormone receptor 0.0213 0.209 0.2401
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0051 0.0305 0.0315
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0213 0.209 0.2401
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1271 0.1774
Loa Loa (eye worm) DR-78 0.01 0.0853 0.1181
Schistosoma mansoni polycystin 1-related 0.0145 0.1338 0.1523
Loa Loa (eye worm) nuclear receptor NHR-67 0.01 0.0853 0.1181
Plasmodium vivax SET domain protein, putative 0.0029 0.0065 0.0052
Loa Loa (eye worm) hypothetical protein 0.0145 0.1338 0.1877
Onchocerca volvulus 0.0139 0.1271 0.4192
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Onchocerca volvulus Peroxidase homolog 0.0105 0.09 0.2934
Loa Loa (eye worm) hypothetical protein 0.01 0.0853 0.1181
Brugia malayi nuclear hormone receptor family member nhr-6 0.01 0.0853 0.1174
Schistosoma mansoni single-minded 0.0106 0.0914 0.1028
Schistosoma mansoni hypothetical protein 0.0078 0.0603 0.0664
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0054 0.0339 0.0443
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0363 0.0478
Schistosoma mansoni tyrosinase precursor 0.0091 0.0745 0.083
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0139 0.1271 0.1444
Loa Loa (eye worm) CYP4Cod1 0.0056 0.0363 0.0478
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0091 0.0745 0.1019
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0127 0.0563
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0139 0.1271 0.1774
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0139 0.1271 0.1774
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0047 0.0266 0.0865
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0139 0.1271 0.1781
Loa Loa (eye worm) hypothetical protein 0.0064 0.0451 0.0604
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0064 0.0451 0.0597
Loa Loa (eye worm) tyrosinase 1 0.0091 0.0745 0.1026
Echinococcus granulosus nuclear factor of activated T cells 5 0.0257 0.2574 0.2967
Schistosoma mansoni jun-related protein 0.0305 0.3097 0.3578
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1321 0.4301
Loa Loa (eye worm) hypothetical protein 0.0098 0.0831 0.1149
Loa Loa (eye worm) hypothetical protein 0.0356 0.3661 0.5207
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0213 0.209 0.2949
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1321 0.4301
Leishmania major cathepsin L-like protease 0.0075 0.0572 0.1862
Onchocerca volvulus 0.0075 0.0569 0.181
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0139 0.1271 0.1774
Brugia malayi Nuclear hormone receptor E75 0.01 0.0853 0.1174
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.024 0.2384 0.7763
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0064 0.0451 0.0486
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0213 0.209 0.2401
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0064 0.0451 0.0486
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0065 0.0036
Schistosoma mansoni hypothetical protein 0.0036 0.0144 0.0128
Brugia malayi Cytochrome P450 family protein 0.0047 0.0266 0.0331
Loa Loa (eye worm) hypothetical protein 0.066 0.7002 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0985 0.1371
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0144 0.0128
Schistosoma mansoni nAChR subunit 0.0139 0.1271 0.1444
Brugia malayi Protein kinase domain containing protein 0.005 0.03 0.0381
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0953 0.1073
Trypanosoma cruzi cysteine peptidase, putative 0.0075 0.0572 0.1862
Loa Loa (eye worm) RNA binding protein 0.0132 0.1201 0.168
Loa Loa (eye worm) hypothetical protein 0.0139 0.1271 0.1781
Brugia malayi Pre-SET motif family protein 0.0029 0.0065 0.0044
Echinococcus multilocularis jun protein 0.0375 0.3869 0.448
Onchocerca volvulus Dual oxidase homolog 0.0105 0.09 0.2934
Echinococcus multilocularis GPCR, family 2 0.0036 0.0144 0.0128
Loa Loa (eye worm) hypothetical protein 0.0088 0.0711 0.0978
Echinococcus granulosus nAChR subunit 0.0075 0.0569 0.0624
Onchocerca volvulus Peroxidase homolog 0.0105 0.09 0.2934
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.005 0.03 0.031
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1201 0.1363
Schistosoma mansoni hypothetical protein 0.0145 0.1338 0.1523
Onchocerca volvulus 0.0139 0.1271 0.4192
Brugia malayi nuclear hormone receptor 0.01 0.0853 0.1174
Onchocerca volvulus 0.0091 0.0745 0.2408
Loa Loa (eye worm) hypothetical protein 0.0112 0.0985 0.1371
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1033 0.144

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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