Detailed information for compound 90008

Basic information

Technical information
  • TDR Targets ID: 90008
  • Name: (7-acetyloxy-4-oxo-2-phenylthiochromen-6-yl) acetate
  • MW: 354.376 | Formula: C19H14O5S
  • H donors: 0 H acceptors: 3 LogP: 3.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Oc1cc2sc(cc(=O)c2cc1OC(=O)C)c1ccccc1
  • InChi: 1S/C19H14O5S/c1-11(20)23-16-8-14-15(22)9-18(13-6-4-3-5-7-13)25-19(14)10-17(16)24-12(2)21/h3-10H,1-2H3
  • InChiKey: LILWGOSWVMYOBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (7-acetoxy-4-oxo-2-phenyl-thiochromen-6-yl) acetate
  • acetic acid (7-acetoxy-4-oxo-2-phenyl-1-benzothiopyran-6-yl) ester
  • (7-acetyloxy-4-oxo-2-phenyl-thiochromen-6-yl) ethanoate
  • acetic acid (7-acetoxy-4-keto-2-phenyl-thiochromen-6-yl) ester
  • acetic acid (7-acetoxy-4-oxo-2-phenyl-6-thiochromenyl) ester
  • 6,7-Diacetoxy-2-phenylthiochromen-4-one
  • 6,7-diAcO-2Ph-Bzthiopyran4one
  • AIDS-042955
  • AIDS042955

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0051 0.0524 0.0893
Onchocerca volvulus 0.003 0.028 0.0879
Toxoplasma gondii sugar transporter ST3 0.003 0.028 0.0421
Brugia malayi Major Facilitator Superfamily protein 0.003 0.028 0.0477
Onchocerca volvulus 0.003 0.028 0.0879
Leishmania major importin beta-1 subunit, putative 0.0027 0.0254 0.3274
Schistosoma mansoni cpg binding protein 0.0034 0.0325 0.0815
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0269 0.2967 1
Echinococcus multilocularis snurportin 1 0.0359 0.3989 0.6799
Echinococcus multilocularis transient receptor potential ion channel A 0.0105 0.1126 0.192
Brugia malayi Sugar transporter family protein 0.0211 0.2315 0.3947
Schistosoma mansoni importin beta-1 0.0034 0.0325 0.0816
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0657 0.1121
Brugia malayi Major Facilitator Superfamily protein 0.003 0.028 0.0477
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.042 0.0715
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0198 0.416
Brugia malayi Transient-receptor-potential like protein 0.004 0.0401 0.0683
Onchocerca volvulus 0.0042 0.042 0.133
Entamoeba histolytica HEAT repeat domain containing protein 0.0006 0.0018 0.0155
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0283 0.0482
Brugia malayi recombination factor GdRad54 0.0009 0.0047 0.008
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.042 0.1379
Loa Loa (eye worm) intermediate filament protein 0.003 0.0283 0.0482
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.034 0.3774 0.5685
Schistosoma mansoni paired box protein pax-6 0.0005 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0047 0.008
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0007 0.0012
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.028 0.5885
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.008 0.0136
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0069 0.0724 0.1235
Onchocerca volvulus 0.003 0.028 0.0879
Leishmania major hypothetical protein, conserved 0.001 0.0065 0.0832
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.1154 0.1967
Trichomonas vaginalis glucose transporter, putative 0.003 0.028 0.0913
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.042 0.0715
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0672 0.0672
Brugia malayi Pax transcription factor protein 2 0.0281 0.3107 0.5296
Echinococcus multilocularis musashi 0.003 0.0283 0.0482
Trichomonas vaginalis sugar transport protein, putative 0.003 0.028 0.0913
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0009 0.0047 0.0608
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0672 0.1146
Entamoeba histolytica heat shock transcription factor, putative 0.0007 0.0024 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0347 0.0869
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0672 0.0672
Trichomonas vaginalis esterase, putative 0.0042 0.042 0.1369
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0009 0.0047 0.0118
Plasmodium falciparum mitogen-activated protein kinase 2 0.034 0.3774 0.3774
Brugia malayi RNA, U transporter 1 0.0096 0.1023 0.1744
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Plasmodium vivax aspartate--tRNA ligase, putative 0.0007 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0065 0.0211
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0069 0.0724 0.1235
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.001 0.0064 0.0821
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.042 0.5412
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0657 0.1121
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Leishmania major aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0396 0.1299
Echinococcus multilocularis importin 5 0.0006 0.0018 0.0031
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0672 0.1013
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0065 0.0832
Loa Loa (eye worm) hypothetical protein 0.0068 0.0713 0.1216
Echinococcus multilocularis solute carrier family 22 0.003 0.028 0.0477
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Brugia malayi Aspartyl-tRNA synthetase 0.0007 0.0026 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0347 0.0591
Brugia malayi Pre-SET motif family protein 0.0244 0.2687 0.4581
Trichomonas vaginalis set domain proteins, putative 0.0277 0.3065 1
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0007 0.0027 0.0046
Leishmania major lysyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Loa Loa (eye worm) TAR-binding protein 0.007 0.0736 0.1255
Onchocerca volvulus 0.003 0.028 0.0879
Onchocerca volvulus 0.003 0.028 0.0879
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.008 0.1033
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0475 0.081
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0347 0.0522
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0657 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0225 0.034
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.008 0.1033
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0069 0.0724 0.1235
Schistosoma mansoni transient receptor potential channel 0.0072 0.0754 0.189
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.008 0.1033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.072 0.1806
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0.0027 0.0067
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0026 0.0045
Entamoeba histolytica DNA repair protein, putative 0.0009 0.0047 0.0399
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0215 0.0366
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0475 0.6134
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.042 0.1379
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.028 0.0477
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0347 0.0591
Schistosoma mansoni heat shock transcription factor 0.0007 0.0024 0.0061
Mycobacterium leprae Probable lipase LipE 0.0042 0.042 0.6315
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0522 0.1308
Schistosoma mansoni survival motor neuron protein 0.0107 0.1154 0.2894
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0522 0.0889
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0672 0.0672
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0065 0.0832
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.028 0.361
Echinococcus multilocularis SPRY domain containing protein 0.0009 0.0047 0.008
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0401 0.0683
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0224
Entamoeba histolytica Ran family GTPase 0.0025 0.0225 0.1906
Entamoeba histolytica DNA repair protein, putative 0.0009 0.0047 0.0399
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Onchocerca volvulus Heat shock factor protein 2 homolog 0.011 0.1182 0.3791
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0006 0.0012 0.0154
Brugia malayi Importin beta-1 subunit 0.0034 0.0325 0.0555
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0672 0.0672
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0627 0.1069
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0475 0.6134
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0672 0.867
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0018 0.0028
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0254 0.0828
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0225 0.0384
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0681 0.879
Mycobacterium ulcerans hypothetical protein 0.0042 0.042 0.8823
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.042 0.8823
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0007 0.0027 0.0087
Echinococcus granulosus paired box protein pax 6 0.0005 0.0007 0.0012
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0012 0.008 0.0121
Loa Loa (eye worm) hypothetical protein 0.0036 0.0347 0.0591
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0475 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0325 0.0555
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0254 0.0828
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Schistosoma mansoni hypothetical protein 0.0069 0.0724 0.1816
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0006 0.0013 0.0031
Brugia malayi Sugar transporter family protein 0.003 0.028 0.0477
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0009 0.0047 0.008
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trypanosoma cruzi glucose transporter, putative 0.003 0.028 0.361
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0672 0.0672
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0681 0.879
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0026 0.0045
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0069 0.0724 0.1235
Plasmodium vivax DNA repair protein RAD54, putative 0.0009 0.0047 0.0047
Onchocerca volvulus Putative transporter 0.003 0.028 0.0879
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Trypanosoma brucei glucose transporter 2A 0.0065 0.0681 0.879
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0006 0.0012 0.002
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.008 0.0136
Brugia malayi RNA binding protein 0.007 0.0736 0.1255
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0006 0.0012 0.0012
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.008 0.1033
Mycobacterium tuberculosis Conserved protein 0.0042 0.042 0.1379
Echinococcus granulosus DNA repair and recombination protein RAD54B 0.0009 0.0047 0.008
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0065 0.0211
Leishmania major replication factor A, 51kDa subunit, putative 0.0006 0.0012 0.0154
Leishmania major hypothetical protein, conserved 0.001 0.0065 0.0832
Plasmodium vivax transportin, putative 0.0006 0.0018 0.0018
Echinococcus granulosus importin subunit beta 1 0.0034 0.0325 0.0555
Loa Loa (eye worm) latrophilin receptor protein 2 0.0069 0.0724 0.1235
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0006 0.0012 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.042 0.1379
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0672 0.0672
Trypanosoma cruzi hexose transporter 0.0065 0.0681 0.879
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0544 0.7019
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.028 0.361
Brugia malayi intermediate filament protein 0.003 0.0283 0.0482
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus granulosus calcium activated potassium channel 0.0008 0.0033 0.0056
Giardia lamblia Glycyl-tRNA synthetase 0.0012 0.008 0.1217
Echinococcus multilocularis calcium activated potassium channel 0.0008 0.0033 0.0056
Plasmodium vivax asparagine--tRNA ligase, putative 0.0007 0.0026 0.0026
Echinococcus granulosus solute carrier family 22 0.003 0.028 0.0477
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0012 0.008 0.023
Trichomonas vaginalis conserved hypothetical protein 0.003 0.028 0.0913
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0198 0.416
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.028 0.0477
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Schistosoma mansoni hypothetical protein 0.0211 0.2315 0.5805
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0069 0.0724 0.1235
Plasmodium falciparum importin beta, putative 0.0034 0.0325 0.0325
Echinococcus granulosus survival motor neuron protein 1 0.0526 0.5867 1
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0018 0.0031
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0627 0.1069
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0672 0.1146
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.005 0.0085
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0006 0.0012 0.0018
Schistosoma mansoni hypothetical protein 0.0359 0.3989 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0681 0.879
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0522 0.0889
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0325 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.003 0.028 0.0913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0522 0.1308
Loa Loa (eye worm) hypothetical protein 0.0009 0.0047 0.008
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.008 0.1683
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0071 0.012
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0325 0.4198
Echinococcus multilocularis SPRY domain containing protein 0.0009 0.0047 0.008
Treponema pallidum threonyl-tRNA synthetase 0.0012 0.008 0.4047
Trypanosoma brucei Replication factor A protein 1 0.0006 0.0012 0.0154
Schistosoma mansoni heat shock transcription factor 0.0007 0.0024 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Entamoeba histolytica heat shock transcription factor, putative 0.0007 0.0024 0.0206
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0007 0.0027 0.0087
Echinococcus multilocularis lamin dm0 0.003 0.0283 0.0482
Schistosoma mansoni lamin 0.003 0.0283 0.0709
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0775 0.0775
Entamoeba histolytica heat shock transcription factor, putative 0.0007 0.0024 0.0206
Schistosoma mansoni intermediate filament proteins 0.003 0.0283 0.0709
Loa Loa (eye worm) hypothetical protein 0.0009 0.0047 0.008
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.008 0.0136
Trichomonas vaginalis ran, putative 0.0025 0.0225 0.0736
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0672 0.0672
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0028 0.0091
Onchocerca volvulus 0.003 0.028 0.0879
Schistosoma mansoni tar DNA-binding protein 0.007 0.0736 0.1846
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Echinococcus granulosus histidyl tRNA synthetase 0.0007 0.0027 0.0046
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0238 0.0406
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0027 0.0346
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0007 0.0026 0.0045
Mycobacterium ulcerans hypothetical protein 0.001 0.0065 0.1357
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0006 0.0012 0.0015
Onchocerca volvulus 0.003 0.028 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.003 0.028 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Echinococcus granulosus lamin 0.003 0.0283 0.0482
Loa Loa (eye worm) hypothetical protein 0.004 0.0401 0.0683
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0225 0.0384
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0396 0.1299
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0007 0.0012
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0754 0.1285
Toxoplasma gondii anticodon binding domain-containing protein 0.0007 0.0027 0.004
Mycobacterium tuberculosis Conserved hypothetical protein 0.001 0.0065 0.0178
Leishmania major hypothetical protein, conserved 0.0042 0.042 0.5412
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Plasmodium falciparum glycine--tRNA ligase 0.0007 0.0027 0.0027
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0012 0.008 0.1055
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Onchocerca volvulus 0.003 0.028 0.0879
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0775 0.1168
Brugia malayi paired box pox-meso protein 0.0005 0.0007 0.0012
Echinococcus multilocularis survival motor neuron protein 1 0.0526 0.5867 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0475 0.0475
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0123
Loa Loa (eye worm) hypothetical protein 0.011 0.1182 0.2016
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0006 0.0012 0.0039
Schistosoma mansoni sugar transporter 0.003 0.028 0.0702
Onchocerca volvulus 0.003 0.028 0.0879
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Entamoeba histolytica protein kinase, putative 0.0064 0.0672 0.5684
Echinococcus granulosus dna repair and recombination protein rad54 0.0009 0.0047 0.008
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0007 0.0026 0.0045
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Loa Loa (eye worm) hypothetical protein 0.0042 0.042 0.0715
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Echinococcus granulosus solute carrier family 22 0.003 0.028 0.0477
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0109 0.0186
Giardia lamblia Aspartyl-tRNA synthetase 0.0007 0.0026 0.0403
Loa Loa (eye worm) hypothetical protein 0.0108 0.1167 0.1989
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Loa Loa (eye worm) type III restriction enzyme 0.0009 0.0047 0.008
Brugia malayi beta-lactamase 0.0042 0.042 0.0715
Loa Loa (eye worm) hypothetical protein 0.0042 0.042 0.0715
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.028 0.0906
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.042 0.0715
Trypanosoma brucei histidyl-tRNA synthetase 0.0007 0.0027 0.0346
Mycobacterium ulcerans integral membrane transport protein 0.003 0.028 0.5885
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0681 0.2223
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.028 0.0906
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0007 0.0026 0.0045
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0225 0.0225
Plasmodium vivax CDK-related protein kinase 6, putative 0.0894 1 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0657 0.1648
Echinococcus multilocularis lamin 0.003 0.0283 0.0482
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.034 0.3774 0.3774
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.042 0.1379
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0347 0.0591
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0218 0.2404 0.4098
Echinococcus multilocularis dna repair and recombination protein rad54 0.0009 0.0047 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0522 0.0889
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0401 0.0683
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0754 0.1285
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0007 0.0012
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0006 0.0012 0.002
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Giardia lamblia Hypothetical protein 0.0006 0.0012 0.0182
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.042 0.5412
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0012
Giardia lamblia Threonyl-tRNA synthetase 0.0012 0.008 0.1217
Onchocerca volvulus 0.0032 0.0305 0.0959
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Loa Loa (eye worm) pax transcription factor protein 2 0.0281 0.3107 0.5296
Loa Loa (eye worm) hypothetical protein 0.0063 0.0657 0.1121
Echinococcus granulosus solute carrier family 22 0.003 0.028 0.0477
Brugia malayi Cam kinase protein 1 0.0064 0.0672 0.1146
Schistosoma mansoni cpg binding protein 0.0032 0.0305 0.0764
Onchocerca volvulus 0.003 0.028 0.0879
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0475 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.042 0.1369
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0007 0.0026 0.0086
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0672 0.0672
Trypanosoma cruzi sugar transporter, putative 0.003 0.028 0.361
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0254 0.3274
Toxoplasma gondii OB-fold nucleic acid binding domain-containing protein 0.0006 0.0012 0.0018
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0007 0.0026 0.0045
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0475 0.7233
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Mycobacterium tuberculosis Conserved protein 0.0042 0.042 0.1379
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0007 0.0027 0.0564
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0639 0.0963
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0672 0.1685
Echinococcus granulosus intermediate filament protein 0.003 0.0283 0.0482
Echinococcus multilocularis dna repair and recombination protein rad54 0.0009 0.0047 0.008
Toxoplasma gondii sugar transporter ST1 0.003 0.028 0.0421
Brugia malayi hypothetical protein 0.003 0.028 0.0477
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Plasmodium vivax replication protein A1, large subunit, putative 0.0006 0.0012 0.0012
Entamoeba histolytica hypothetical protein 0.0047 0.0475 0.4021
Loa Loa (eye worm) hypothetical protein 0.0069 0.0724 0.1235
Schistosoma mansoni paired box protein pax-6 0.0005 0.0007 0.0018
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0006 0.0018 0.0237
Onchocerca volvulus 0.0036 0.0347 0.1094
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0657 0.1121
Loa Loa (eye worm) hypothetical protein 0.0009 0.0047 0.008
Echinococcus multilocularis 0.0009 0.0047 0.008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0736 0.1255
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0028 0.0091
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Entamoeba histolytica hypothetical protein 0.0027 0.0254 0.2146
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0475 0.1192
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0775 1
Leishmania major aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0544 0.7019
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0681 0.879
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0544 0.0544
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Plasmodium falciparum aspartate--tRNA ligase 0.0007 0.0026 0.0026
Echinococcus multilocularis histidyl tRNA synthetase 0.0007 0.0027 0.0046
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0672 0.1146
Schistosoma mansoni hypothetical protein 0.0149 0.1627 0.4078
Schistosoma mansoni importin-beta 2 0.0006 0.0018 0.0046
Leishmania major hypothetical protein, conserved 0.003 0.028 0.361
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0681 0.2223
Trichomonas vaginalis hypothetical protein 0.0006 0.0018 0.006
Mycobacterium tuberculosis Conserved protein 0.0042 0.042 0.1379
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.028 0.0477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0522 0.0889
Echinococcus granulosus General substrate transporter 0.0181 0.1982 0.3379
Schistosoma mansoni sugar transporter 0.003 0.028 0.0702
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.1182 1
Loa Loa (eye worm) hypothetical protein 0.0149 0.1627 0.2772
Toxoplasma gondii protein kinase, putative 0.0595 0.6639 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0359 0.3989 0.6799
Trypanosoma cruzi replication Factor A 28 kDa subunit, putative 0.0006 0.0012 0.0154
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.028 0.5885
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0006 0.0012 0.0039
Brugia malayi beta-lactamase family protein 0.0042 0.042 0.0715
Brugia malayi hypothetical protein 0.0053 0.0544 0.0927
Toxoplasma gondii ABC1 family protein 0.0042 0.042 0.0632
Brugia malayi Gooseberry protein 0.0005 0.0007 0.0012
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.2315 0.3488
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Mycobacterium leprae conserved hypothetical protein 0.001 0.0065 0.0815
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0225 0.2908
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0007 0.0026 0.0045
Leishmania major glucose transporter, lmgt1 0.0065 0.0681 0.879
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Plasmodium falciparum asparagine--tRNA ligase 0.0007 0.0026 0.0026
Entamoeba histolytica heat shock transcription factor, putative 0.0007 0.0024 0.0206
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0225 0.0384
Echinococcus multilocularis GPCR, family 2 0.0069 0.0724 0.1235
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0018 0.0031
Onchocerca volvulus 0.0107 0.1154 0.37
Toxoplasma gondii sugar transporter ST2 0.003 0.028 0.0421
Schistosoma mansoni protein kinase 0.0064 0.0672 0.1685
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0225 0.2908
Plasmodium vivax threonine--tRNA ligase, putative 0.0012 0.008 0.008
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.028 0.0421
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0065 0.0832
Plasmodium falciparum replication protein A1, large subunit 0.0006 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0544 0.0927
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0775 0.0775
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.042 0.1369
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0681 0.2223
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0198 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.008 0.1683
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0475 0.0475
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0012 0.008 0.0261
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0754 0.1285
Entamoeba histolytica hypothetical protein 0.0006 0.0012 0.0101
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.042 0.1369
Loa Loa (eye worm) hypothetical protein 0.0064 0.0672 0.1146
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0775 1
Plasmodium falciparum DNA repair and recombination protein RAD54, putative 0.0009 0.0047 0.0047
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.028 0.0913
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.028 0.028
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0127 0.0216
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus multilocularis General substrate transporter 0.0181 0.1982 0.3379
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0091
Brugia malayi hypothetical protein 0.0526 0.5867 1
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.008 0.0136
Echinococcus multilocularis transportin 1 0.0006 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.042 0.0715
Leishmania major histidyl-tRNA synthetase, putative 0.0007 0.0027 0.0346
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0007 0.0026 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0005 0.0007 0.0012
Echinococcus granulosus lamin dm0 0.003 0.0283 0.0482
Onchocerca volvulus 0.0042 0.042 0.133
Toxoplasma gondii aspartate-tRNA ligase 0.0007 0.0026 0.004
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0657 0.2145
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.042 0.5412
Echinococcus multilocularis dna repair and recombination protein rad54 0.0009 0.0047 0.008
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0325 0.4198
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0007 0.0027 0.0958
Schistosoma mansoni cpg binding protein 0.0034 0.0325 0.0815
Loa Loa (eye worm) hypothetical protein 0.003 0.0283 0.0482
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0681 0.2223
Schistosoma mansoni protein kinase 0.0064 0.0672 0.1685
Brugia malayi latrophilin 2 splice variant baaae 0.0149 0.1627 0.2772
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Brugia malayi Calcitonin receptor-like protein seb-1 0.0218 0.2404 0.4098
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0775 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Brugia malayi TAR-binding protein 0.007 0.0736 0.1255
Echinococcus granulosus SPRY domain containing protein 0.0009 0.0047 0.008
Schistosoma mansoni glucose transport protein 0.0211 0.2315 0.5805
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.042 0.1052
Onchocerca volvulus 0.003 0.028 0.0879
Plasmodium vivax sugar transporter, putative 0.003 0.028 0.028
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0681 0.2223
Schistosoma mansoni glucose transport protein 0.0211 0.2315 0.5805
Schistosoma mansoni hypothetical protein 0.0107 0.1154 0.2894
Schistosoma mansoni DNA repair and recombination protein rad54-related 0.0009 0.0047 0.0118
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0681 0.879
Brugia malayi Major Facilitator Superfamily protein 0.003 0.028 0.0477
Brugia malayi hypothetical protein 0.0034 0.0332 0.0567
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.028 1
Trypanosoma brucei sugar transporter, putative 0.003 0.028 0.361
Echinococcus granulosus GPCR family 2 0.0069 0.0724 0.1235
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0006 0.0012 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0007 0.0027 0.0227
Chlamydia trachomatis histidine--tRNA ligase 0.0007 0.0027 0.0564
Echinococcus granulosus SPRY domain containing protein 0.0009 0.0047 0.008
Brugia malayi Latrophilin receptor protein 2 0.0069 0.0724 0.1235
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0681 0.879
Plasmodium vivax glycine--tRNA ligase, putative 0.0012 0.008 0.008
Schistosoma mansoni lamin 0.003 0.0283 0.0709
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0324 0.0553
Mycobacterium ulcerans sugar transporter 0.003 0.028 0.5885
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Echinococcus granulosus paired box protein pax 1 0.0005 0.0007 0.0012
Echinococcus granulosus importin 5 0.0006 0.0018 0.0031
Leishmania major glucose transporter, lmgt2 0.0065 0.0681 0.879
Echinococcus granulosus paired box protein pax 6 0.0005 0.0007 0.0012
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0775 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0544 0.7019
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.042 0.8823
Trichomonas vaginalis conserved hypothetical protein 0.003 0.028 0.0913
Onchocerca volvulus 0.0042 0.042 0.133
Loa Loa (eye worm) hypothetical protein 0.0218 0.2404 0.4098
Schistosoma mansoni heat shock transcription factor 0.0007 0.0024 0.0061
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.1182 1
Brugia malayi major facilitator superfamily protein 0.003 0.028 0.0477
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0736 0.1255
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.042 0.1369
Loa Loa (eye worm) hypothetical protein 0.0042 0.042 0.0715
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Entamoeba histolytica protein kinase, putative 0.0064 0.0672 0.5684
Onchocerca volvulus 0.003 0.028 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0657 0.5559
Schistosoma mansoni ran 0.0025 0.0225 0.0565
Mycobacterium ulcerans lipase LipD 0.0042 0.042 0.8823
Chlamydia trachomatis threonine--tRNA ligase 0.0012 0.008 0.1683
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.001 0.0065 0.0832
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0012
Mycobacterium ulcerans beta-lactamase 0.0042 0.042 0.8823
Trichomonas vaginalis helicase, putative 0.0007 0.0028 0.0091
Entamoeba histolytica heat shock transcription factor, putative 0.011 0.1182 1
Treponema pallidum asparaginyl-tRNA synthetase 0.0007 0.0026 0.1338
Schistosoma mansoni transient receptor potential channel 4 0.0108 0.1167 0.2926
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0657 0.1121
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.042 0.1379
Brugia malayi Sugar transporter family protein 0.003 0.028 0.0477
Loa Loa (eye worm) paired box protein 0.0005 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.041 0.1339
Mycobacterium ulcerans aspartyl-tRNA synthetase 0.0007 0.0026 0.0557
Schistosoma mansoni sugar transporter 0.003 0.028 0.0702
Echinococcus granulosus cpg binding protein 0.0034 0.0325 0.0554
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0305 0.0519
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0475 0.081
Echinococcus granulosus translational activator gcn1 0.0006 0.0018 0.0031
Loa Loa (eye worm) hypothetical protein 0.0042 0.042 0.0715
Brugia malayi kap beta 3 protein 0.0006 0.0018 0.0031
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Echinococcus multilocularis paired box protein pax 6 0.0005 0.0007 0.0012
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.008 0.0136
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0283 0.0482
Plasmodium falciparum asparagine--tRNA ligase 0.0007 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0012 0.008 0.0136
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0657 1
Schistosoma mansoni hypothetical protein 0.0069 0.0724 0.1816
Schistosoma mansoni glucose transporter 0.003 0.028 0.0702
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0348 0.4494
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0127 0.0216
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0754 0.1285
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0225 0.0384
Onchocerca volvulus 0.0281 0.3107 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0672 0.1146
Giardia lamblia Asparaginyl-tRNA synthetase 0.0007 0.0026 0.0403
Leishmania major DNA repair and recombination protein RAD54, putative 0.0009 0.0047 0.0608
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Echinococcus multilocularis cpg binding protein 0.0034 0.0325 0.0554
Schistosoma mansoni paired box protein pax-1-related 0.0005 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0109 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0522 0.0889
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0225 0.3429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0522 0.1308
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0012 0.008 0.0677
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0475 0.6134
Brugia malayi glycyl-tRNA synthetase 0.0012 0.008 0.0136
Chlamydia trachomatis aspartate--tRNA(Asp/Asn) ligase 0.0007 0.0026 0.0557
Brugia malayi beta-lactamase family protein 0.0042 0.042 0.0715
Schistosoma mansoni hypothetical protein 0.0069 0.0724 0.1816
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Onchocerca volvulus 0.003 0.028 0.0879
Echinococcus granulosus transient receptor potential ion channel A 0.0105 0.1126 0.192
Loa Loa (eye worm) hypothetical protein 0.0042 0.042 0.0715
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.042 0.0715
Brugia malayi vab-3 gene. 0.0005 0.0007 0.0012
Schistosoma mansoni paired box protein pax-6 0.0005 0.0007 0.0018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0091
Loa Loa (eye worm) sugar transporter 0.0211 0.2315 0.3947
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0775 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.042 0.042
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0218 0.2404 0.4098
Echinococcus multilocularis 0.0009 0.0047 0.008
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0672 0.2193
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Toxoplasma gondii glycyl-tRNA synthetase 0.0012 0.008 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0065 0.0211
Loa Loa (eye worm) hypothetical protein 0.0063 0.0657 0.1121
Schistosoma mansoni protein kinase 0.0064 0.0672 0.1685
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Trypanosoma cruzi hexose transporter, putative 0.003 0.028 0.361
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.028 0.0477
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0012 0.0154
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.005 0.0126
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0244 0.2687 0.4581
Schistosoma mansoni aspartyl-tRNA synthetase 0.0006 0.0012 0.003
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0672 0.0672
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0475 0.1551
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.028 0.0477
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Treponema pallidum aspartyl-tRNA synthetase 0.0007 0.0026 0.1338
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0175
Echinococcus granulosus transportin 1 0.0006 0.0018 0.0031
Brugia malayi CXXC zinc finger family protein 0.0032 0.0305 0.0519
Plasmodium falciparum threonine--tRNA ligase 0.0012 0.008 0.008
Schistosoma mansoni hypothetical protein 0.0006 0.0012 0.003
Echinococcus multilocularis paired box protein pax 1 0.0005 0.0007 0.0012
Schistosoma mansoni heat shock transcription factor 0.0007 0.0024 0.0061
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Loa Loa (eye worm) beta-lactamase 0.0042 0.042 0.0715
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0657 0.1648
Toxoplasma gondii HEAT repeat-containing protein 0.0006 0.0018 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0091
Schistosoma mansoni hypothetical protein 0.0024 0.0215 0.0538
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.001 0.0065 0.0097
Leishmania major asparaginyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.005 0.0085
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0012 0.008 0.286
Plasmodium falciparum hexose transporter 0.0211 0.2315 0.2315
Brugia malayi hypothetical protein 0.003 0.028 0.0477
Leishmania major replication Factor A 28 kDa subunit, putative 0.0006 0.0012 0.0154
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0544 0.082
Plasmodium vivax histidine--tRNA ligase, putative 0.0007 0.0027 0.0027
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.042 0.1379
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.028 0.0477
Plasmodium falciparum protein kinase 7 0.0595 0.6639 0.6639
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0007 0.0026 0.0224
Onchocerca volvulus 0.0277 0.3065 0.9864
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0396 0.5947
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0681 0.2223
Giardia lamblia Sugar-proton symporter 0.003 0.028 0.4257
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.0029 0.0277 0.0472
Leishmania major GTP-binding protein, putative 0.0025 0.0225 0.2908
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0475 0.0716
Trypanosoma cruzi histidyl-tRNA synthetase 0.0007 0.0027 0.0346
Leishmania major glycyl tRNA synthetase, putative 0.0007 0.0027 0.0346
Trypanosoma brucei DNA repair and recombination protein RAD54, putative 0.0009 0.0047 0.0608
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0007 0.0026 0.0341
Giardia lamblia Hexose transporter 0.003 0.028 0.4257
Schistosoma mansoni tar DNA-binding protein 0.007 0.0736 0.1846
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2315 0.3947
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0475 0.081
Loa Loa (eye worm) vab-3 0.0005 0.0007 0.0012
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0012 0.008 0.0677
Echinococcus multilocularis solute carrier family 22 0.003 0.028 0.0477
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0006 0.0012 0.0154
Echinococcus multilocularis heat shock transcription factor 0.0007 0.0024 0.0041
Schistosoma mansoni tar DNA-binding protein 0.007 0.0736 0.1846
Loa Loa (eye worm) hypothetical protein 0.0037 0.036 0.0613
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.008 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0681 0.2223
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Schistosoma mansoni glucose transport protein 0.0211 0.2315 0.5805
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0225 0.2908
Brugia malayi replication factor A 73 kDa subunit 0.0006 0.0012 0.002
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0672 0.1013
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0347 0.0869
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0012 0.008 0.286
Mycobacterium leprae conserved hypothetical protein 0.0042 0.042 0.6315
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0475 1
Leishmania major hypothetical protein, conserved 0.0006 0.0018 0.0237
Echinococcus granulosus heat shock transcription factor 0.0007 0.0024 0.0041
Echinococcus granulosus snurportin 1 0.0359 0.3989 0.6799
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0007 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0065 0.0832
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0225 0.0225
Echinococcus multilocularis translational activator gcn1 0.0006 0.0018 0.0031
Schistosoma mansoni hypothetical protein 0.0069 0.0724 0.1816
Loa Loa (eye worm) hypothetical protein 0.0005 0.0007 0.0012
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0254 0.0828
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Schistosoma mansoni aspartyl-tRNA synthetase 0.0007 0.0026 0.0066
Echinococcus granulosus SPRY domain containing protein 0.0009 0.0047 0.008
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0475 0.7182
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0475 0.1192
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.2315 0.3947
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0091
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.042 0.1369
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0215 0.0366
Echinococcus multilocularis transient receptor potential gamma protein 0.0108 0.1167 0.1989
Echinococcus multilocularis solute carrier family 22 0.003 0.028 0.0477
Plasmodium vivax asparagine--tRNA ligase, putative 0.0007 0.0026 0.0026
Schistosoma mansoni ran 0.0025 0.0225 0.0565
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0091
Schistosoma mansoni transient receptor potential channel 0.0108 0.1167 0.2926
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.005 0.0085
Onchocerca volvulus 0.003 0.028 0.0879
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.042 0.1379
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Schistosoma mansoni transient receptor potential channel 0.0072 0.0754 0.189
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0007 0.0027 0.0346
Schistosoma mansoni tar DNA-binding protein 0.007 0.0736 0.1846
Plasmodium vivax importin-beta 2, putative 0.0034 0.0325 0.0325
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0325 0.049
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0672 0.1146
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.008 0.1033
Plasmodium falciparum transportin 0.0006 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.028 0.0477
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0522 0.0889
Leishmania major protein kinase, putative 0.0064 0.0672 0.867
Wolbachia endosymbiont of Brugia malayi aspartyl-tRNA synthetase 0.0007 0.0026 0.0946
Onchocerca volvulus 0.003 0.0283 0.0889
Echinococcus multilocularis solute carrier family 22 0.003 0.028 0.0477
Onchocerca volvulus 0.003 0.0283 0.0889
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0007 0.0012
Plasmodium falciparum nucleic acid binding protein, putative 0.0006 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0526 0.5867 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0475 0.081
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.008 0.0136
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.028 0.0702
Schistosoma mansoni tar DNA-binding protein 0.007 0.0736 0.1846
Leishmania major hypothetical protein, conserved 0.0053 0.0544 0.7019
Brugia malayi paired box protein 0.0005 0.0007 0.0012
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0347 0.0869
Trypanosoma cruzi DNA repair and recombination protein RAD54, putative 0.0009 0.0047 0.0608
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.2315 0.7555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.042 0.1052
Loa Loa (eye worm) RNA binding protein 0.007 0.0736 0.1255
Schistosoma mansoni sugar transporter 0.003 0.028 0.0702
Schistosoma mansoni replication factor A 1 rfa1 0.0006 0.0012 0.003
Leishmania major glucose transporter, lmgt3 0.0065 0.0681 0.879
Plasmodium vivax hexose transporter 0.0211 0.2315 0.2315
Plasmodium falciparum histidine--tRNA ligase, putative 0.0007 0.0027 0.0027
Schistosoma mansoni histidyl-tRNA synthetase 0.0007 0.0027 0.0067
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0007 0.0026 0.0045
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0109 0.0186
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0028 0.0091
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.005 0.0085
Echinococcus multilocularis tar DNA binding protein 0.007 0.0736 0.1255
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0672 0.1013
Trypanosoma brucei glucose transporter 1E 0.0065 0.0681 0.879
Echinococcus granulosus tar DNA binding protein 0.007 0.0736 0.1255
Treponema pallidum glycyl-tRNA synthetase 0.0007 0.0027 0.1356
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0347 0.0869
Loa Loa (eye worm) sugar transporter 0.003 0.028 0.0477
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0072 0.0123
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0544 0.0544
Trichomonas vaginalis sugar transporter, putative 0.003 0.028 0.0913
Brugia malayi 'Paired box' domain containing protein 0.0005 0.0007 0.0012
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.008 0.0201
Trypanosoma brucei glucose transporter, putative 0.0065 0.0681 0.879
Brugia malayi major facilitator superfamily protein 0.003 0.028 0.0477
Echinococcus granulosus solute carrier family 22 0.003 0.028 0.0477
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0072 0.0123
Brugia malayi Pre-SET motif family protein 0.0036 0.0347 0.0591
Trypanosoma cruzi Replication factor A protein 1 0.0006 0.0012 0.0154
Echinococcus granulosus transient receptor potential gamma protein 0.0108 0.1167 0.1989
Brugia malayi HSF-type DNA-binding domain containing protein 0.011 0.1182 0.2016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0028 0.0091
Plasmodium vivax SET domain protein, putative 0.0036 0.0347 0.0347
Onchocerca volvulus 0.003 0.028 0.0879
Trichomonas vaginalis conserved hypothetical protein 0.003 0.028 0.0913
Brugia malayi hypothetical protein 0.003 0.028 0.0477
Loa Loa (eye worm) 63kd antigen 0.0007 0.0026 0.0045
Onchocerca volvulus 0.003 0.028 0.0879
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0544 0.0544
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0681 0.879
Schistosoma mansoni threonyl-tRNA synthetase 0.0007 0.0027 0.0067

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 1 Cellular protein-linked DNA breaks in KB oral carcinoma cell culture treated in triplicate at 50 microM for 1 hr ChEMBL. 8642556
ED50 (functional) NT 0 ug ml-1 Effective dose against 50% reduction in Human lung carcinoma(A-549)cell number after 3-day incubation. ChEMBL. 8642556
ED50 (functional) NT 0 ug ml-1 Effective dose against 50% reduction in Human ileocecal carcinoma (HCT-8) cell number after 3-day incubation. ChEMBL. 8642556
ED50 (functional) = 0.65 ug ml-1 Effective dose of the compound against growth of HIV infected H9 lymphocytes ChEMBL. 8642556
ED50 (functional) = 0.65 ug ml-1 Effective dose of the compound against growth of HIV infected H9 lymphocytes ChEMBL. 8642556
ED50 (functional) = 4.58 ug ml-1 Effective dose against 50% reduction in Human CNS tumor (TE671) cell number after 3-day incubation ChEMBL. 8642556
ED50 (functional) = 4.58 ug ml-1 Effective dose against 50% reduction in Human CNS tumor (TE671) cell number after 3-day incubation ChEMBL. 8642556
ED50 (functional) = 4.83 ug ml-1 Effective dose against 50% reduction in Murine leukemia (P-388) cell number after 3-day incubation ChEMBL. 8642556
ED50 (functional) = 4.83 ug ml-1 Effective dose against 50% reduction in Murine leukemia (P-388) cell number after 3-day incubation ChEMBL. 8642556
ED50 (functional) = 5.5 ug ml-1 Effective dose against 50% reduction in Human epidermoid carcinoma of the nasopharynx (KB) cell number after 3-day incubation ChEMBL. 8642556
ED50 (functional) = 5.5 ug ml-1 Effective dose against 50% reduction in Human melanoma (RPMI)cell number after 3-day incubation ChEMBL. 8642556
ED50 (functional) = 5.5 ug ml-1 Effective dose against 50% reduction in Human epidermoid carcinoma of the nasopharynx (KB) cell number after 3-day incubation ChEMBL. 8642556
IC50 (functional) = 3 ug ml-1 Inhibitory activity of the compound against growth of uninfected H9 lymphocytes ChEMBL. 8642556
IC50 (functional) = 3 ug ml-1 Inhibitory activity of the compound against growth of uninfected H9 lymphocytes ChEMBL. 8642556
Inhibition (binding) = 0 % Inhibitory activity of the compound against human DNA topoisomerase I at dose 100 microM ChEMBL. 8642556
Inhibition (binding) = 0 % Inhibitory activity of the compound against human DNA topoisomerase I at dose 100 microM ChEMBL. 8642556
Inhibition (binding) = 100 % Inhibitory activity of the compound against human DNA topoisomerase II at dose 100 microM ChEMBL. 8642556
Inhibition (binding) = 100 % Inhibitory activity of the compound against human DNA topoisomerase II at dose 100 microM ChEMBL. 8642556
Therapeutic index (functional) = 4.6 Therapeutic index valued has been determined in H9 cells ChEMBL. 8642556

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 8642556

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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