Detailed information for compound 91390

Basic information

Technical information
  • TDR Targets ID: 91390
  • Name: (2R)-2-amino-2-(2,3-dihydro-1H-inden-2-yl)ace tic acid
  • MW: 191.226 | Formula: C11H13NO2
  • H donors: 2 H acceptors: 2 LogP: -1.12 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@@H](C(=O)O)C1Cc2c(C1)cccc2
  • InChi: 1S/C11H13NO2/c12-10(11(13)14)9-5-7-3-1-2-4-8(7)6-9/h1-4,9-10H,5-6,12H2,(H,13,14)/t10-/m1/s1
  • InChiKey: GUDHMDVRURNAHL-SNVBAGLBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-amino-2-indan-2-yl-acetic acid
  • (2R)-2-amino-2-(2-indanyl)acetic acid
  • (2R)-2-azanyl-2-(2,3-dihydro-1H-inden-2-yl)ethanoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Histamine H3 receptor Starlite/ChEMBL References
Homo sapiens histamine receptor H2 Starlite/ChEMBL References
Homo sapiens histamine receptor H1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 405 aa 25.2 %
Brugia malayi hypothetical protein histamine receptor H2 397 aa 333 aa 23.1 %
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 384 aa 22.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0034 0.0053
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.1578 0.1578
Mycobacterium tuberculosis Conserved protein 0.0038 0.0108 0.038
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0034 0.0053
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0034 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0012 0.0108
Brugia malayi Glycosyl hydrolases family 31 protein 0.017 0.0644 0.0993
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0123 0.0189
Brugia malayi Latrophilin receptor protein 2 0.008 0.028 0.0432
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0108 0.0968
Schistosoma mansoni hypothetical protein 0.008 0.028 0.0432
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0166
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000003499 0.00000000064581
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0034 0.0034
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0012 0.0108
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0033 0.1728
Onchocerca volvulus 0.0087 0.0307 0.0473
Schistosoma mansoni alpha glucosidase 0.0038 0.0108 0.0166
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0123 0.0189
Loa Loa (eye worm) norepinephrine transporter 0.1615 0.6489 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.004 0.0061
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0123 0.0189
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0274 0.1064 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0022 0.0042 0.0065
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.002 0.0031
Schistosoma mansoni cpg binding protein 0.0092 0.0326 0.0502
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.004 0.0061
Onchocerca volvulus 0.003 0.0076 0.0117
Trichomonas vaginalis glutaminase, putative 0.0286 0.1111 1
Schistosoma mansoni cpg binding protein 0.0092 0.0326 0.0502
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0033 0.005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000003499 0.00000000031484
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0274 0.1064 0.164
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0274 0.1064 0.164
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0123 0.0189
Echinococcus granulosus expressed conserved protein 0.0091 0.0323 0.0498
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0576 0.2283 1
Schistosoma mansoni chromobox protein 0.0068 0.023 0.0354
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0067
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0034 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0067
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000003499 0.00000000064581
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0274 0.1064 0.164
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0123 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.008 0.0716
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0336 0.0517
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0123 0.0189
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0123 0.0123
Brugia malayi hypothetical protein 0.0022 0.0044 0.0067
Trypanosoma brucei glucosidase, putative 0.0038 0.0108 1
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0121 0.1087
Brugia malayi conserved hypotetical protein 0.002 0.0034 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0123 0.0189
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.002 0.0031
Trichomonas vaginalis helicase, putative 0.002 0.0035 0.0311
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0027 0.0064 0.0064
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.004 0.0061
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000003499 0.00000000031484
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.093 0.4015
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Toxoplasma gondii exonuclease III APE 0.0019 0.0033 0.0306
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0034 0.0053
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0026 0.024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Echinococcus multilocularis tumor protein p63 0.0332 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0039
Onchocerca volvulus 0.0049 0.0152 0.0234
Schistosoma mansoni hypothetical protein 0.0699 0.2784 0.4289
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Onchocerca volvulus 0.0087 0.0306 0.0472
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0098
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0123 0.0189
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.018
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0108 0.038
Echinococcus granulosus L aminoadipate semialdehyde 0.0087 0.0307 0.0473
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0121 0.1087
Schistosoma mansoni glutaminase 0.0286 0.1111 0.1713
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.008 0.0716
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0108 0.0971
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0123 0.0123
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0123 0.0189
Echinococcus granulosus tumor protein p63 0.0332 0.13 0.2003
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0131 0.1234
Onchocerca volvulus 0.0029 0.0073 0.0113
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.004 0.0359
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0123 0.0189
Schistosoma mansoni hypothetical protein 0.0174 0.0658 0.1014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0044 0.0067
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.07 0.1078
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0108 0.0968
Entamoeba histolytica hypothetical protein 0.0011 0.00000000003499 0.00000000064581
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0123 0.0189
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0123 0.0123
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0054 0.0507
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0274 0.1064 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0347 0.6402
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0274 0.1064 0.1064
Brugia malayi nuclear receptor NHR-88 0.0042 0.0123 0.0189
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0054 0.0143
Plasmodium vivax hypothetical protein, conserved 0.0274 0.1064 1
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0274 0.1064 0.164
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0109 0.0982
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.004 0.0061
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0121 0.0186
Schistosoma mansoni hypothetical protein 0.008 0.028 0.0432
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.0029 0.0071 0.0109
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0012 0.0019
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.017 0.0644 0.0993
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0336 0.0336
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0034 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0336 0.0517
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Entamoeba histolytica hypothetical protein 0.0024 0.0054 0.0995
Echinococcus multilocularis expressed conserved protein 0.0091 0.0323 0.0323
Schistosoma mansoni nuclear hormone receptor 0.002 0.0034 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0123 0.0189
Echinococcus granulosus lamin dm0 0.0029 0.0073 0.0113
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0049 0.0911
Brugia malayi nuclear receptor RXR 0.002 0.0034 0.0053
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0202
Onchocerca volvulus 0.1615 0.6489 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0012 0.0018
Brugia malayi intermediate filament protein 0.0029 0.0073 0.0113
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0033 0.005
Schistosoma mansoni microtubule-associated protein tau 0.074 0.2949 0.4544
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.008 0.0716
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0039
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0196 0.0302
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0202
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0034 0.0053
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0123 0.0189
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0108 0.038
Onchocerca volvulus 0.0038 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0018
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0073 0.0113
Entamoeba histolytica hypothetical protein 0.0145 0.0542 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0164 0.062 0.5827
Schistosoma mansoni hypothetical protein 0.0699 0.2784 0.4289
Echinococcus multilocularis protoporphyrinogen oxidase 0.0044 0.0131 0.0131
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0012 0.0221
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.0991 0.0991
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0123 0.0189
Schistosoma mansoni amine oxidase 0.0044 0.0131 0.0202
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0012 0.0018
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.0542 0.0542
Toxoplasma gondii hypothetical protein 0.0274 0.1064 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0108 0.0166
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.004 0.0375
Brugia malayi steroid hormone receptor 0.0042 0.0123 0.0189
Mycobacterium ulcerans hypothetical protein 0.0023 0.0049 0.0098
Plasmodium vivax amine transporter, putative 0.0274 0.1064 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0044 0.0131 0.0485
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0644 0.0644
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0108 0.0166
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0033 0.0033
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0274 0.1064 0.164
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0051 0.0161 0.0248
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.023 0.0354
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0044 0.0131 0.0202
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0012 0.0108
Onchocerca volvulus 0.0023 0.0049 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0123 0.0189
Schistosoma mansoni lamin 0.0029 0.0073 0.0113
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0619 0.2459 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0274 0.1064 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0166
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000003499 0.00000000064581
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0034 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0123 0.0189
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.2034
Echinococcus granulosus geminin 0.0699 0.2784 0.4289
Echinococcus granulosus GPCR family 2 0.008 0.028 0.0432
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000003499 0.000000000053919
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0108 0.996
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0123 0.019
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0123 0.0189
Chlamydia trachomatis protoporphyrinogen oxidase 0.0044 0.0131 0.1019
Loa Loa (eye worm) hypothetical protein 0.0097 0.0347 0.0535
Schistosoma mansoni amine oxidase 0.0044 0.0131 0.0202
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.028 0.028
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.004 0.0061
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0196 0.07
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.8037
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0087 0.0307 0.0473
Brugia malayi CHD4 protein 0.0016 0.002 0.0031
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0042 0.0042
Brugia malayi hypothetical protein 0.0145 0.0542 0.0835
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.019
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Onchocerca volvulus 0.0038 0.0108 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.8005
Loa Loa (eye worm) RecQ helicase 0.0021 0.004 0.0061
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0619 0.2459 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0336 0.0517
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0108 0.0337
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0054 0.0273
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0336 0.0517
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0131 1
Brugia malayi hypothetical protein 0.0256 0.0991 0.1528
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0123 0.0189
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0108 0.0968
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0044 0.0067
Echinococcus granulosus cpg binding protein 0.0092 0.0326 0.0502
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0012 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Schistosoma mansoni sodium-dependent amino acid transporter 0.0274 0.1064 0.164
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.002 0.0031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0049 0.0152 0.0234
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0123 0.0189
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0196 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.8005
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0044 0.0131 0.1234
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.004 0.004
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.00000000003499 0.00000000032878
Entamoeba histolytica recQ family helicase, putative 0.0021 0.004 0.0736
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Mycobacterium ulcerans hypothetical protein 0.0038 0.0108 0.0337
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.018
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0123 0.0189
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0108 0.0971
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0123 0.0189
Echinococcus multilocularis serotonin transporter 0.1615 0.6489 0.6489
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.1014
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0108 0.0968
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.00000000003499 0.000000000053919
Echinococcus multilocularis Chromo domain 0.0011 0.00000000003499 0.00000000003499
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0123 0.0189
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0034 0.0053
Brugia malayi hypothetical protein 0.0022 0.0044 0.0067
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0401 0.1578 0.2431
Mycobacterium tuberculosis Possible oxidoreductase 0.0044 0.0131 0.0485
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0012 0.0012
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0131 0.0202
Echinococcus granulosus chromobox protein 1 0.0068 0.023 0.0354
Toxoplasma gondii hypothetical protein 0.0274 0.1064 1
Onchocerca volvulus 0.0274 0.1064 0.164
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000003499 0.000000000053919
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0274 0.1064 0.164
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0123 0.0189
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0152 0.0234
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0274 0.1064 0.164
Echinococcus granulosus microtubule associated protein 2 0.074 0.2949 0.4544
Echinococcus granulosus lysine specific histone demethylase 1A 0.0044 0.0131 0.0202
Mycobacterium tuberculosis Conserved protein 0.0038 0.0108 0.038
Toxoplasma gondii histone lysine-specific demethylase 0.0044 0.0131 0.1234
Echinococcus granulosus sodium and chloride dependent glycine 0.0274 0.1064 0.164
Echinococcus multilocularis bloom syndrome protein 0.0021 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0202
Onchocerca volvulus 0.0274 0.1064 0.164
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0044 0.0067
Brugia malayi nuclear receptor NHR-88 0.002 0.0034 0.0053
Schistosoma mansoni survival motor neuron protein 0.0052 0.0166 0.0256
Loa Loa (eye worm) hypothetical protein 0.1615 0.6489 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.028 0.0432
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0054 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0034 0.0053
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.00000000003499 0.000000000053919
Schistosoma mansoni cpg binding protein 0.0087 0.0306 0.0472
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0061
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0044 0.0067
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.1992
Echinococcus multilocularis sodium and chloride dependent glycine 0.0274 0.1064 0.1064
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.0042 0.0065
Echinococcus granulosus Chromo domain 0.0011 0.00000000003499 0.000000000053919
Brugia malayi nuclear hormone receptor 0.002 0.0034 0.0053
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0033 0.0048
Echinococcus multilocularis chromobox protein 1 0.0068 0.023 0.023
Mycobacterium ulcerans dehydrogenase 0.0044 0.0131 0.0435
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0076
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0515 0.0794
Brugia malayi glutaminase DH11.1 0.0286 0.1111 0.1713
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0336 0.0517
Onchocerca volvulus 0.0029 0.0073 0.0113
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0049 0.0123
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0196 0.0302
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0022 0.0042 0.0042
Brugia malayi beta-lactamase family protein 0.0038 0.0108 0.0166
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0123 0.0189
Echinococcus multilocularis lamin 0.0029 0.0073 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0123 0.0189
Schistosoma mansoni hypothetical protein 0.0011 0.00000000003499 0.000000000053919
Echinococcus multilocularis sodium and chloride dependent glycine 0.0274 0.1064 0.1064
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0123 0.0189
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0043 0.0384
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0196 0.07
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0018 0.0028
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0012 0.0108
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0026 0.024
Echinococcus granulosus lysosomal alpha glucosidase 0.017 0.0644 0.0993
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.00000000003499 0.00000000032878
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.018
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0123 0.0189
Schistosoma mansoni nuclear hormone receptor 0.002 0.0034 0.0053
Echinococcus multilocularis chromobox protein 1 0.0068 0.023 0.023
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0044 0.0131 0.0202
Echinococcus granulosus intermediate filament protein 0.0029 0.0073 0.0113
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.2034
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0274 0.1064 1
Onchocerca volvulus 0.002 0.0034 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0108 0.1011
Echinococcus granulosus bloom syndrome protein 0.0021 0.004 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.008 0.0716
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0123 0.0189
Trypanosoma cruzi UDP-galactopyranose mutase 0.0044 0.0131 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0196 0.077
Echinococcus granulosus dnaJ subfamily B 0.0401 0.1578 0.2431
Mycobacterium ulcerans beta-lactamase 0.0038 0.0108 0.0337
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0049 0.0911
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0034 0.0053
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0347 0.0535
Schistosoma mansoni chromobox protein 0.0068 0.023 0.0354
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0108 0.1992
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0274 0.1064 0.164
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0042 0.0065
Brugia malayi hypothetical protein 0.002 0.0034 0.0053
Brugia malayi CXXC zinc finger family protein 0.0087 0.0306 0.0472
Plasmodium falciparum amino acid transporter, putative 0.0274 0.1064 1
Schistosoma mansoni amine GPCR 0.0209 0.0799 0.1231
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0054 0.4372
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Schistosoma mansoni nuclear receptor 0.002 0.0034 0.0053
Toxoplasma gondii ABC1 family protein 0.0038 0.0108 0.1011
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0196 0.1841
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.004 0.0375
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0108 0.038
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0098
Echinococcus multilocularis microtubule associated protein 2 0.074 0.2949 0.2949
Schistosoma mansoni alpha-glucosidase 0.0147 0.0548 0.0845
Loa Loa (eye worm) hypothetical protein 0.0256 0.0991 0.1528
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0123 0.0189
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0044 0.0131 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0123 0.019
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.028 0.0432
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0196 0.0196
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.0991 0.1528
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0274 0.1064 0.1064
Echinococcus multilocularis cpg binding protein 0.0092 0.0326 0.0326
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0034 0.0034
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.028 0.0432
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0123 0.0189
Brugia malayi tailless protein 0.002 0.0034 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0049 0.0123
Loa Loa (eye worm) histone methyltransferase 0.0027 0.0064 0.0098
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0123 0.0123
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.028 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0577
Onchocerca volvulus 0.0274 0.1064 0.164
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.0542 0.0835
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0033 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0971
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0034 0.0034
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0108 0.5218
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0166
Onchocerca volvulus 0.0099 0.0354 0.0545
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.008 0.0716
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0108 0.7094
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0108 0.0971
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0274 0.1064 0.1064
Echinococcus multilocularis lysosomal alpha glucosidase 0.017 0.0644 0.0644
Onchocerca volvulus 0.0013 0.0008 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0123 0.0189
Trichomonas vaginalis chromobox protein, putative 0.0068 0.023 0.2069
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.0983 0.1515
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0166
Brugia malayi amine oxidase, flavin-containing family protein 0.0044 0.0131 0.0202
Schistosoma mansoni lamin 0.0029 0.0073 0.0113
Mycobacterium tuberculosis Conserved protein 0.0038 0.0108 0.038
Schistosoma mansoni hypothetical protein 0.0052 0.0166 0.0256
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0108 0.0166
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0034 0.0053
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0033 0.1122
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0034 0.0053
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0018 0.0028
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0108 0.0166
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0033 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Loa Loa (eye worm) hypothetical protein 0.0087 0.0307 0.0473
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0108 0.0166
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0515 0.0515
Echinococcus multilocularis L aminoadipate semialdehyde 0.0087 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.004 0.0117 0.018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0067
Schistosoma mansoni nuclear receptor 0.002 0.0034 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0971
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.004 0.0061
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.005
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0347 0.0535
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0274 0.1064 0.164
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0027 0.0064 0.0098
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0123 0.0189
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0012 0.0108
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0049 0.0153 0.1436
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0015
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0049 0.2034
Brugia malayi SWIRM domain containing protein 0.0044 0.0131 0.0202
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0049 0.0911
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0108 0.0108
Loa Loa (eye worm) serotonin transporter b 0.1615 0.6489 1
Echinococcus granulosus lamin 0.0029 0.0073 0.0113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0076
Schistosoma mansoni hypothetical protein 0.008 0.028 0.0432
Brugia malayi nuclear receptor RXR 0.0022 0.0044 0.0067
Trichomonas vaginalis esterase, putative 0.0038 0.0108 0.0968
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.0983 0.1515
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Mycobacterium ulcerans glutaminase 0.0286 0.1111 0.4461
Loa Loa (eye worm) glutaminase 0.0286 0.1111 0.1713
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.00000000003499 0.00000000003499
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0108 0.038
Mycobacterium leprae Probable lipase LipE 0.0038 0.0108 0.7094
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0202
Loa Loa (eye worm) hypothetical protein 0.1615 0.6489 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000003499 0.00000000031484
Mycobacterium ulcerans lipase LipD 0.0038 0.0108 0.0337
Loa Loa (eye worm) hypothetical protein 0.0014 0.0012 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0336 0.0517
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0026 0.0017
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0109 0.0168
Loa Loa (eye worm) hypothetical protein 0.0174 0.0658 0.1014
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0087 0.0307 0.0473
Mycobacterium ulcerans oxidoreductase 0.0044 0.0131 0.0435
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0044 0.0131 0.1234
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0034 0.0053
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0274 0.1064 0.164
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Echinococcus granulosus sodium and chloride dependent glycine 0.0274 0.1064 0.164
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0108 0.0968
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0034 0.0053
Brugia malayi Heterochromatin protein 1 0.0068 0.023 0.0354
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0123 0.0189
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0274 0.1064 0.164
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.004 0.0359
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0034 0.0053
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0274 0.1064 0.164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0336 0.0517
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0108 0.038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0073 0.0113
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0042 0.0123 0.0189
Onchocerca volvulus 0.0044 0.0131 0.0202
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0044 0.0067
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0971
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0033 0.0602
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0033 0.0306
Entamoeba histolytica hypothetical protein 0.0145 0.0542 1
Echinococcus multilocularis 0.0044 0.0131 0.0131
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0044 0.0131 0.0435
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.00000000003499 0.000000000053919
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0049 0.0098
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0658 0.1014
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0123 0.0189
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.002 0.002
Loa Loa (eye worm) beta-lactamase 0.0038 0.0108 0.0166
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0039
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0054 0.2281
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0005 0.0008
Echinococcus multilocularis geminin 0.0699 0.2784 0.2784
Brugia malayi Nuclear hormone receptor E75 0.002 0.0034 0.0053
Brugia malayi Nuclear hormone receptor E75 0.002 0.0034 0.0053
Schistosoma mansoni intermediate filament proteins 0.0029 0.0073 0.0113
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0123 0.0189
Leishmania major UDP-galactopyranose mutase 0.0044 0.0131 0.6492
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0202
Loa Loa (eye worm) hypothetical protein 0.0038 0.0109 0.0168
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.0043 0.0384
Schistosoma mansoni ap endonuclease 0.0019 0.0033 0.005
Schistosoma mansoni sodium/chloride dependent transporter 0.0274 0.1064 0.164
Plasmodium falciparum protoporphyrinogen oxidase 0.0044 0.0131 0.1234
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0034 0.0053
Loa Loa (eye worm) hypothetical protein 0.0044 0.0131 0.0202
Onchocerca volvulus 0.0052 0.0166 0.0256
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0044 0.0131 1
Loa Loa (eye worm) DR-78 0.002 0.0034 0.0053
Schistosoma mansoni patched 1 0.0042 0.0123 0.019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0033 0.1728
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1615 0.6489 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0274 0.1064 0.164
Onchocerca volvulus 0.002 0.0034 0.0053
Schistosoma mansoni hypothetical protein 0.0145 0.0542 0.0835
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0108 0.0166
Echinococcus multilocularis musashi 0.0029 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0014 0.001 0.0015
Loa Loa (eye worm) glutaminase 2 0.0286 0.1111 0.1713
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0073 0.0113
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0108 0.0166
Brugia malayi beta-lactamase family protein 0.0038 0.0108 0.0166
Brugia malayi ecdysone receptor 0.002 0.0034 0.0053
Entamoeba histolytica hypothetical protein 0.0145 0.0542 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0123 0.0123
Echinococcus granulosus serotonin transporter 0.1615 0.6489 1
Echinococcus multilocularis GPCR, family 2 0.008 0.028 0.028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0123 0.0189
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.004 1
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0044 0.0131 0.0131
Schistosoma mansoni alpha-glucosidase 0.0147 0.0548 0.0845
Brugia malayi chromobox protein homolog 3 0.0038 0.0109 0.0168
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0971
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0054 0.0117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0108 0.0971
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0012 0.0108
Loa Loa (eye worm) hypothetical protein 0.003 0.0076 0.0117
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0166 0.0256
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0044 0.0044
Onchocerca volvulus 0.0038 0.0108 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0123 0.0189
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.004 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0033 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Brugia malayi beta-lactamase 0.0038 0.0108 0.0166
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0013 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0166
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.004 0.2336
Treponema pallidum sodium- and chloride- dependent transporter 0.1615 0.6489 1
Echinococcus granulosus chromobox protein 1 0.0068 0.023 0.0354
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0054 0.0555
Loa Loa (eye worm) hypothetical protein 0.0274 0.1064 0.164
Loa Loa (eye worm) hypothetical protein 0.0254 0.0983 0.1515
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0306 0.0472
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.008 0.0716
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0274 0.1064 0.164
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0073 0.0113
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0123 0.0189
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0196 0.07
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0062 0.0096
Schistosoma mansoni DNA helicase recq5 0.0021 0.004 0.0061
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0108 0.038
Loa Loa (eye worm) hypothetical protein 0.1615 0.6489 1
Leishmania major hypothetical protein, conserved 0.0038 0.0108 0.5197
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0026 0.0039
Loa Loa (eye worm) solute carrier family 6 member 4 0.1615 0.6489 1
Loa Loa (eye worm) hypothetical protein 0.008 0.028 0.0432
Echinococcus multilocularis lamin dm0 0.0029 0.0073 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.008 0.0716
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0044 0.0131 0.1234
Schistosoma mansoni hypothetical protein 0.008 0.028 0.0432
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0108 0.038
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0123 0.0189
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.008 0.0716
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0353 0.0544
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0274 0.1064 0.164
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0049 0.0098
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0274 0.1064 0.164
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1615 0.6489 1
Schistosoma mansoni DNA helicase recq1 0.0021 0.004 0.0061
Brugia malayi SET domain containing protein 0.0013 0.0008 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0109 0.0982
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0054 0.0117
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.0983 0.1515
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0123 0.019
Brugia malayi hypothetical protein 0.0274 0.1064 0.164
Plasmodium vivax hypothetical protein, conserved 0.0044 0.0131 0.1234
Brugia malayi nuclear receptor NHR-67 0.002 0.0034 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0123 0.0189
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.004 0.1517
Plasmodium vivax hypothetical protein, conserved 0.0011 0.00000000003499 0.00000000032878
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0049 0.0098
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0196 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0108 0.0971
Brugia malayi nuclear hormone receptor 0.0042 0.0123 0.0189
Schistosoma mansoni zinc finger protein 0.002 0.0034 0.0053
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.004 0.0375
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0054 0.0033
Onchocerca volvulus 0.0042 0.0123 0.0189
Brugia malayi hypothetical protein 0.002 0.0034 0.0053
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0067
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.004 0.2907
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0054 0.0507
Echinococcus multilocularis protein dispatched 1 0.0047 0.0147 0.0147
Echinococcus multilocularis protein patched 0.0042 0.0123 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0049 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0123 0.0189
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0033 0.0293
Brugia malayi ecdysteroid receptor 0.0042 0.0123 0.0189
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.004 0.0375
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0274 0.1064 0.164
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0108 0.0337
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0033 0.0029
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0054 0.0507
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0044 0.0067
Plasmodium falciparum transporter, putative 0.0274 0.1064 1
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0034 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0049 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0035 0.0311
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0034 0.0053
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0012 0.0108
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0123 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0108 0.8037
Trichomonas vaginalis chromobox protein, putative 0.0068 0.023 0.2069
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0274 0.1064 0.164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0049 0.0098
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0076
Schistosoma mansoni sodium/chloride dependent transporter 0.0274 0.1064 0.164
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0054 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0037 0.0332
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0108 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0064 0.0577
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0034 0.0034
Schistosoma mansoni sodium/chloride dependent transporter 0.1615 0.6489 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0034 0.0053
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0033 0.215
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.028 0.0432
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.0542 0.0835
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0347 0.0347
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.004 0.0359
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0123 0.1108
Loa Loa (eye worm) hypothetical protein 0.0038 0.0108 0.0166
Mycobacterium ulcerans monoamine oxidase 0.0044 0.0131 0.0435
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0336 0.0336
Brugia malayi CHE-14 protein 0.0042 0.0123 0.019
Brugia malayi hypothetical protein 0.0044 0.0131 0.0202
Entamoeba histolytica hypothetical protein 0.0145 0.0542 1
Schistosoma mansoni coup transcription factor 0.0042 0.0123 0.0189

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -7.58 Binding affinity towards Histamine H3 receptor of rat cortical membranes. ChEMBL. 12113836
Ki (binding) = -4.97 Binding affinity towards Histamine H1 receptor of human membranes. ChEMBL. 12113836
Ki (binding) = -4.72 Binding affinity towards Histamine H2 receptor from human membranes ChEMBL. 12113836
Log Ki (binding) = 4.72 Binding affinity towards Histamine H2 receptor from human membranes ChEMBL. 12113836
Log Ki (binding) = 4.97 Binding affinity towards Histamine H1 receptor of human membranes. ChEMBL. 12113836
Log Ki (binding) = 7.58 Binding affinity towards Histamine H3 receptor of rat cortical membranes. ChEMBL. 12113836

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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