Detailed information for compound 914155

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 510.005 | Formula: C17H20ClN3O7S3
  • H donors: 2 H acceptors: 8 LogP: 1.92 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCN(C1CC(C)S(=O)(=O)c2c1cc(s2)S(=O)(=O)N)C(=O)c1cccc(n1)C(=O)O.Cl
  • InChi: 1S/C17H19N3O7S3.ClH/c1-3-20(15(21)11-5-4-6-12(19-11)16(22)23)13-7-9(2)29(24,25)17-10(13)8-14(28-17)30(18,26)27;/h4-6,8-9,13H,3,7H2,1-2H3,(H,22,23)(H2,18,26,27);1H
  • InChiKey: AHNZRIFOIBXRRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus programmed cell death protein 0.005 0.0119 0.0334
Schistosoma mansoni cpg binding protein 0.003 0.0061 0.0073
Echinococcus granulosus Calcium binding protein 0.005 0.0119 0.0335
Echinococcus granulosus sodium and chloride dependent glycine 0.021 0.0572 0.1635
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Brugia malayi Cytochrome P450 family protein 0.003 0.006 0.0058
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0036 0.0096
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0187 0.0505 0.1444
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0036 0.5
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0036 0.5
Echinococcus multilocularis programmed cell death protein 0.005 0.0119 0.0334
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.005 0.0119 0.0119
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0156 0.0349
Trichomonas vaginalis caltractin, putative 0.005 0.0119 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0979 0.2754 0.7891
Echinococcus multilocularis programmed cell death protein 6 0.005 0.0119 0.0335
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0036 0.5
Echinococcus multilocularis glycine receptor subunit beta 0.0404 0.1124 0.3218
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.021 0.0572 0.0572
Toxoplasma gondii centrin family protein 0.005 0.0119 0.1548
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.1124 0.1122
Toxoplasma gondii hypothetical protein 0.021 0.0572 1
Entamoeba histolytica hypothetical protein 0.0639 0.1788 1
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.2236 0.6323 1
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Onchocerca volvulus Putative nachr subunit 0.0979 0.2754 0.2709
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0404 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.2236 0.6323 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0404 0.1124 0.1122
Onchocerca volvulus 0.0404 0.1124 0.107
Brugia malayi Cytochrome P450 family protein 0.0116 0.0305 0.0303
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0036 0.5
Leishmania major cytochrome p450-like protein 0.003 0.006 0.0038
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0218 0.0594 0.0593
Echinococcus multilocularis calcyphosin protein 0.005 0.0119 0.0335
Echinococcus multilocularis programmed cell death protein 0.005 0.0119 0.0334
Loa Loa (eye worm) solute carrier family 6 member 4 0.1238 0.3489 0.3489
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.1124 0.1122
Echinococcus multilocularis sodium and chloride dependent glycine 0.021 0.0572 0.1635
Loa Loa (eye worm) norepinephrine transporter 0.1238 0.3489 0.3489
Toxoplasma gondii calmodulin CAM2 0.005 0.0119 0.1548
Schistosoma mansoni sodium/chloride dependent transporter 0.1238 0.3489 1
Onchocerca volvulus Dual oxidase homolog 0.3532 1 1
Leishmania major ferric reductase, putative 0.2236 0.6323 1
Echinococcus granulosus programmed cell death protein 6 0.005 0.0119 0.0335
Echinococcus granulosus glycine receptor subunit beta 0.0404 0.1124 0.3218
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0036 0.5
Schistosoma mansoni myosin light chain 0.005 0.0119 0.0241
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0404 0.1124 0.1124
Echinococcus granulosus cpg binding protein 0.0032 0.0066 0.0182
Loa Loa (eye worm) ACC-1 protein 0.0404 0.1124 0.1124
Schistosoma mansoni myosin regulatory light chain 0.005 0.0119 0.0241
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0187 0.0505 0.0504
Trypanosoma cruzi centrin, putative 0.005 0.0119 0.0132
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0404 0.1124 0.1122
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.021 0.0572 0.1554
Loa Loa (eye worm) acetylcholine receptor protein 0.0187 0.0505 0.0505
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0979 0.2754 0.2752
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.021 0.0572 0.1554
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0036 0.5
Schistosoma mansoni myosin regulatory light chain 0.005 0.0119 0.0241
Echinococcus granulosus glycine receptor subunit alpha 1 0.0404 0.1124 0.3218
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.1124 0.1122
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0036 0.5
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0404 0.1124 0.3218
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0404 0.1124 0.3218
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Onchocerca volvulus 0.0187 0.0505 0.0447
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0979 0.2754 0.7891
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.021 0.0572 0.1635
Trypanosoma cruzi centrin-3 0.005 0.0119 0.0132
Echinococcus multilocularis sodium and chloride dependent glycine 0.021 0.0572 0.1635
Schistosoma mansoni nAChR subunit 0.0187 0.0505 0.1361
Onchocerca volvulus 0.1238 0.3489 0.3449
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Echinococcus multilocularis glycine receptor subunit beta 0.0404 0.1124 0.3218
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0404 0.1124 0.3218
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0404 0.1124 0.3218
Brugia malayi Cytochrome P450 family protein 0.003 0.006 0.0058
Trypanosoma brucei caltractin, putative 0.005 0.0119 0.0132
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.2236 0.6323 1
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.005 0.0119 0.0058
Plasmodium vivax amine transporter, putative 0.021 0.0572 1
Echinococcus multilocularis Calcium binding protein 0.005 0.0119 0.0335
Loa Loa (eye worm) ACC-1 protein 0.0404 0.1124 0.1124
Entamoeba histolytica calmodulin, putative 0.005 0.0119 0.0001
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0218 0.0594 0.1618
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0404 0.1124 0.3152
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Loa Loa (eye worm) cytochrome P450 0.0021 0.0036 0.0036
Onchocerca volvulus 0.005 0.0119 0.0058
Loa Loa (eye worm) hypothetical protein 0.1238 0.3489 0.3489
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.1296 0.3653 0.3653
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0404 0.1124 0.3152
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0404 0.1124 0.3218
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.021 0.0572 0.1554
Entamoeba histolytica grainin 2 0.005 0.0119 0.0001
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Brugia malayi CXXC zinc finger family protein 0.003 0.0061 0.0059
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Toxoplasma gondii calmodulin, putative 0.005 0.0119 0.1552
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.021 0.0572 0.1635
Plasmodium vivax hypothetical protein, conserved 0.021 0.0572 1
Echinococcus multilocularis nAChR subunit 0.0404 0.1124 0.3218
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Echinococcus multilocularis cpg binding protein 0.0032 0.0066 0.0182
Treponema pallidum sodium- and chloride- dependent transporter 0.1238 0.3489 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0218 0.0594 0.0593
Brugia malayi hypothetical protein 0.0187 0.0505 0.0504
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.021 0.0572 0.1554
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0036 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.1124 0.1122
Brugia malayi cytochrome P450 0.0021 0.0036 0.0034
Trypanosoma brucei centrin-3 0.005 0.0119 0.0132
Onchocerca volvulus 0.0404 0.1124 0.107
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0404 0.1124 0.3218
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0187 0.0505 0.0504
Loa Loa (eye worm) GABA receptor subunit 0.0218 0.0594 0.0594
Brugia malayi excitatory GABA receptor EXP-1A 0.0404 0.1124 0.1122
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0036 0.5
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.021 0.0572 0.1554
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Brugia malayi hypothetical protein 0.0187 0.0505 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.0119 0.0132
Trichomonas vaginalis caltractin, putative 0.005 0.0119 1
Brugia malayi hypothetical protein 0.021 0.0572 0.057
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0036 0.5
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Toxoplasma gondii hypothetical protein 0.021 0.0572 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0404 0.1124 0.3152
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0404 0.1124 0.3218
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0187 0.0505 0.1444
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0979 0.2754 0.7891
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0187 0.0505 0.0504
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0036 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0404 0.1124 0.1122
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Loa Loa (eye worm) cytochrome P450 family protein 0.0116 0.0305 0.0305
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0404 0.1124 0.3218
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0404 0.1124 0.3218
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0187 0.0505 0.1444
Brugia malayi hypothetical protein 0.0187 0.0505 0.0504
Plasmodium falciparum transporter, putative 0.021 0.0572 1
Onchocerca volvulus 0.0187 0.0505 0.0447
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Plasmodium falciparum amino acid transporter, putative 0.021 0.0572 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.021 0.0572 0.057
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0979 0.2754 0.2754
Echinococcus granulosus Myosin regulatory light chain 0.005 0.0119 0.0334
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0404 0.1124 0.3218
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0218 0.0594 0.1618
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0187 0.0505 0.0505
Trypanosoma cruzi centrin, putative 0.005 0.0119 0.0132
Loa Loa (eye worm) hypothetical protein 0.1238 0.3489 0.3489
Echinococcus granulosus serotonin transporter 0.1238 0.3489 1
Brugia malayi RasGEF domain containing protein 0.005 0.0119 0.0117
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1238 0.3489 0.3488
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0404 0.1124 0.3152
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0036 0.5
Schistosoma mansoni neurotransmitter gated ion channel 0.0218 0.0594 0.1618
Echinococcus granulosus glycine receptor subunit alpha 1 0.0404 0.1124 0.3218
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.021 0.0572 0.1554
Onchocerca volvulus 0.0404 0.1124 0.107
Onchocerca volvulus 0.0404 0.1124 0.107
Toxoplasma gondii calcium binding protein precursor, putative 0.005 0.0119 0.1552
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.021 0.0572 0.1554
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0404 0.1124 0.1122
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0404 0.1124 0.3152
Onchocerca volvulus 0.0218 0.0594 0.0537
Schistosoma mansoni acetylcholine receptor-related 0.0187 0.0505 0.1361
Brugia malayi Probable myosin regulatory light chain 0.005 0.0119 0.0117
Loa Loa (eye worm) hypothetical protein 0.005 0.0119 0.0119
Trypanosoma cruzi cytochrome P450, putative 0.003 0.006 0.0038
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.006 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Schistosoma mansoni sodium/chloride dependent transporter 0.021 0.0572 0.1554
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0036 0.5
Entamoeba histolytica hypothetical protein 0.0218 0.0594 0.2849
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.021 0.0572 1
Schistosoma mansoni cpg binding protein 0.0032 0.0066 0.0087
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0137 0.1885
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0404 0.1124 0.1122
Echinococcus granulosus glycine receptor subunit beta 0.0404 0.1124 0.3218
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.005 0.0119 0.0058
Onchocerca volvulus 0.0218 0.0594 0.0537
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.021 0.0572 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0187 0.0505 0.1444
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Echinococcus granulosus nAChR subunit 0.0218 0.0594 0.1699
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0036 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.006 0.006
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0404 0.1124 0.1124
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0036 0.5
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.1124 0.1122
Brugia malayi hypothetical protein 0.0187 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0404 0.1124 0.1122
Loa Loa (eye worm) myosin Light Chain family member 0.005 0.0119 0.0119
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.021 0.0572 0.1635
Loa Loa (eye worm) blistered cuticle protein 3 0.3532 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Brugia malayi Neuronal calcium sensor family protein 1 0.005 0.0119 0.0117
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0979 0.2754 0.2754
Echinococcus multilocularis 0.0021 0.0036 0.0096
Onchocerca volvulus 0.0187 0.0505 0.0447
Brugia malayi Myosin regulatory light chain 1 0.005 0.0119 0.0117
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0979 0.2754 0.7891
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Brugia malayi Cytochrome P450 family protein 0.0021 0.0036 0.0034
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0187 0.0505 0.1444
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0218 0.0594 0.0593
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.021 0.0572 0.1635
Schistosoma mansoni cpg binding protein 0.0032 0.0066 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.021 0.0572 0.1554
Loa Loa (eye worm) CYP4Cod1 0.003 0.006 0.006
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.021 0.0572 0.057
Schistosoma mansoni acetylcholine receptor subunit beta 0.0187 0.0505 0.1361
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0404 0.1124 0.1122
Schistosoma mansoni nAChR subunit 0.0187 0.0505 0.1361
Schistosoma mansoni nAChR subunit 0.0404 0.1124 0.3152
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Schistosoma mansoni neurotransmitter gated ion channel 0.0187 0.0505 0.1361
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0404 0.1124 0.1122
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Loa Loa (eye worm) myosin regulatory light chain 1 0.005 0.0119 0.0119
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.021 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0404 0.1124 0.3218
Brugia malayi hypothetical protein 0.0187 0.0505 0.0504
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.021 0.0572 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0218 0.0594 0.0593
Schistosoma mansoni neurotransmitter gated ion channel 0.0187 0.0505 0.1361
Brugia malayi Cation transporter family protein 0.0404 0.1124 0.1122
Schistosoma mansoni calmodulin-related 0.005 0.0119 0.0241
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Brugia malayi Sodium:neurotransmitter symporter family protein 0.021 0.0572 0.057
Onchocerca volvulus 0.021 0.0572 0.0515
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0036 0.5
Echinococcus granulosus calcyphosin protein 0.005 0.0119 0.0335
Loa Loa (eye worm) LGC-31 protein 0.0404 0.1124 0.1124
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0404 0.1124 0.1122
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Echinococcus granulosus sodium and chloride dependent glycine 0.021 0.0572 0.1635
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.0505 0.0504
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0979 0.2754 0.7891
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0036 0.5
Echinococcus granulosus nAChR subunit 0.0404 0.1124 0.3218
Onchocerca volvulus 0.021 0.0572 0.0515
Trichomonas vaginalis calcium binding protein, putative 0.005 0.0119 1
Onchocerca volvulus 0.0404 0.1124 0.107
Onchocerca volvulus 0.021 0.0572 0.0515
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0187 0.0505 0.0504
Loa Loa (eye worm) hypothetical protein 0.1238 0.3489 0.3489
Echinococcus granulosus glycine receptor subunit alpha 1 0.0404 0.1124 0.3218
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0036 0.5
Toxoplasma gondii EF hand domain-containing protein 0.005 0.0119 0.1552
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0002
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0404 0.1124 0.1122
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0404 0.1124 0.1124
Loa Loa (eye worm) serotonin transporter b 0.1238 0.3489 0.3489
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0061 0.0061
Onchocerca volvulus 0.0404 0.1124 0.107
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0979 0.2754 0.7891
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Mycobacterium leprae putative cytochrome p450 0.0021 0.0036 0.5
Echinococcus multilocularis Myosin regulatory light chain 0.005 0.0119 0.0334
Brugia malayi Sodium:neurotransmitter symporter family protein 0.021 0.0572 0.057
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0187 0.0505 0.0505
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.021 0.0572 0.1554
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0036 0.5
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.006 0.006
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0404 0.1124 0.3218
Brugia malayi Cation transporter family protein 0.0404 0.1124 0.1122
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Trypanosoma cruzi cytochrome P450, putative 0.003 0.006 0.0038
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0404 0.1124 0.3152
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.021 0.0572 1
Trypanosoma brucei cytochrome P450, putative 0.003 0.006 0.0038
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.021 0.0572 0.1635
Loa Loa (eye worm) hypothetical protein 0.0404 0.1124 0.1124
Schistosoma mansoni sodium-dependent amino acid transporter 0.021 0.0572 0.1554
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1238 0.3489 1
Echinococcus multilocularis nAChR subunit 0.0218 0.0594 0.1699
Giardia lamblia Programmed cell death protein-like protein 0.005 0.0119 1
Onchocerca volvulus 0.005 0.0119 0.0058
Loa Loa (eye worm) hypothetical protein 0.021 0.0572 0.0572
Loa Loa (eye worm) hypothetical protein 0.0187 0.0505 0.0505
Echinococcus multilocularis serotonin transporter 0.1238 0.3489 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.0594 0.0594
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0036 0.5
Echinococcus granulosus uncharacterized sodium dependent transporter 0.021 0.0572 0.1635
Echinococcus granulosus uncharacterized sodium dependent transporter 0.021 0.0572 0.1635
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0404 0.1124 0.1124
Brugia malayi Cation transporter family protein 0.0404 0.1124 0.1122
Loa Loa (eye worm) hypothetical protein 0.005 0.0119 0.0119

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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