Detailed information for compound 931753

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.48 | Formula: C25H24F2N4O3
  • H donors: 1 H acceptors: 2 LogP: 3.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)N1CN(Cc2c(F)cccc2F)C(=O)N(C1=O)C[C@@H](c1ccccc1)N
  • InChi: 1S/C25H24F2N4O3/c1-34-19-10-5-9-18(13-19)31-16-29(14-20-21(26)11-6-12-22(20)27)24(32)30(25(31)33)15-23(28)17-7-3-2-4-8-17/h2-13,23H,14-16,28H2,1H3/t23-/m0/s1
  • InChiKey: AQRXSPRQFWKMBM-QHCPKHFHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens gonadotropin-releasing hormone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GnHR receptor homolog Get druggable targets OG5_131719 All targets in OG5_131719
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0241 0.4088 0.4195
Brugia malayi Bromodomain containing protein 0.0037 0.0318 0.0273
Echinococcus granulosus leukotriene A 4 hydrolase 0.0036 0.0291 0.0264
Schistosoma mansoni P2X receptor subunit 0.0067 0.0869 0.0891
Brugia malayi prolyl oligopeptidase family protein 0.0115 0.1754 0.1716
Plasmodium vivax aspartyl protease, putative 0.0102 0.1511 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.0728 0.0747
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.092 0.0911
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0947 0.6153
Brugia malayi beta-lactamase family protein 0.0071 0.0947 0.0905
Schistosoma mansoni hypothetical protein 0.0283 0.4855 0.4982
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0947 0.5364
Echinococcus multilocularis hypothetical protein 0.004 0.0374 0.0349
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0947 0.094
Loa Loa (eye worm) hypothetical protein 0.0071 0.0947 0.0972
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0947 0.094
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0947 0.0905
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0607 0.059
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0374 0.0349
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0291 0.0264
Brugia malayi mbt repeat family protein 0.0046 0.0488 0.0444
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0947 0.1084
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Trypanosoma cruzi prolyl endopeptidase 0.0547 0.9745 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0102 0.1514 0.1554
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0723 0.1823
Echinococcus granulosus calpain 0.004 0.0374 0.0349
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0036 0.0291 0.1672
Echinococcus multilocularis prolyl endopeptidase 0.0547 0.9745 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0704 0.069
Giardia lamblia Alanyl dipeptidyl peptidase 0.007 0.092 0.5
Loa Loa (eye worm) hypothetical protein 0.007 0.092 0.0944
Plasmodium falciparum plasmepsin VIII, putative 0.0023 0.0046 0.0078
Echinococcus multilocularis calpain family protein 1, d 0.0079 0.1083 0.108
Mycobacterium tuberculosis Probable peptidase 0.0226 0.3806 0.448
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0453 0.0431
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0869 0.0859
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Loa Loa (eye worm) hypothetical protein 0.0071 0.0947 0.0972
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0947 0.0883
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.007 0.092 0.0944
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0723 0.0709
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0232 0.391 0.3984
Echinococcus multilocularis aminopeptidase N 0.0346 0.6036 0.618
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0115 0.1754 0.1761
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0112 0.1694 0.1709
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0102 0.1514 0.1523
Brugia malayi hypothetical protein 0.0025 0.0095 0.0049
Entamoeba histolytica dipeptidyl-peptidase, putative 0.007 0.092 0.5643
Loa Loa (eye worm) hypothetical protein 0.0071 0.0947 0.0972
Onchocerca volvulus 0.0102 0.1514 0.1513
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0291 0.0264
Toxoplasma gondii aspartyl protease ASP1 0.0059 0.0728 0.0703
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0723 0.1823
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0453 0.0431
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0183 0.3016 0.3071
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0226 0.3806 0.3884
Echinococcus granulosus acylamino acid releasing enzyme 0.007 0.092 0.0912
Brugia malayi mbt repeat family protein 0.0046 0.0488 0.0444
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0226 0.3806 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Onchocerca volvulus 0.0067 0.0859 0.0838
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0112 0.1694 0.1709
Loa Loa (eye worm) hypothetical protein 0.004 0.0362 0.0372
Loa Loa (eye worm) hypothetical protein 0.0066 0.0851 0.0873
Trypanosoma brucei Aminopeptidase M1, putative 0.0102 0.1514 0.147
Trypanosoma brucei prolyl oligopeptidase, putative 0.0226 0.3806 0.3846
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0107 0.1605 0.1647
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0723 0.1823
Plasmodium vivax aspartyl protease, putative 0.0102 0.1511 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0095 0.0062
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0607 0.0563
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0095 0.041
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0059 0.0728 0.0703
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0947 0.5364
Schistosoma mansoni gabp alpha 0.0073 0.0971 0.0996
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.0374 0.0383
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0374 0.0349
Loa Loa (eye worm) prolyl oligopeptidase 0.0232 0.391 0.4013
Entamoeba histolytica hypothetical protein, conserved 0.007 0.092 0.5643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0453 0.0431
Plasmodium falciparum plasmepsin I 0.0059 0.0728 0.4698
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0095 0.0062
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0607 0.059
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0112 0.1694 0.1739
Trypanosoma brucei antigen, putative 0.004 0.0374 0.0288
Trypanosoma brucei kinesin, putative 0.0028 0.015 0.0056
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0115 0.1754 0.1771
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0291 0.0246
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0036 0.0291 0.0264
Plasmodium falciparum plasmepsin X 0.0102 0.1511 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0102 0.1514 0.3922
Echinococcus granulosus calpain 7 C02 family 0.004 0.0374 0.0349
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0095 0.0051
Loa Loa (eye worm) hypothetical protein 0.0547 0.9745 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0241 0.4088 0.4195
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0947 0.094
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.0291 0.0679
Trypanosoma cruzi Aminopeptidase M1, putative 0.0102 0.1514 0.1523
Schistosoma mansoni aminopeptidase A (M01 family) 0.0036 0.0291 0.0299
Loa Loa (eye worm) hypothetical protein 0.0062 0.0776 0.0796
Loa Loa (eye worm) hypothetical protein 0.0107 0.1605 0.1647
Loa Loa (eye worm) hypothetical protein 0.0053 0.0607 0.0623
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Brugia malayi Fli-1 protein 0.022 0.3705 0.3676
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0947 0.1084
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Schistosoma mansoni Mername-AA248 (C02 family) 0.004 0.0374 0.0383
Echinococcus multilocularis calpain A 0.0112 0.1694 0.1709
Mycobacterium tuberculosis Conserved protein 0.0071 0.0947 0.1084
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0723 0.0742
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0488 0.0467
Plasmodium falciparum plasmepsin III 0.0023 0.0046 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.092 0.0911
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0723 0.0708
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0066 0.0851 0.0841
Echinococcus granulosus aminopeptidase N 0.0346 0.6036 0.618
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0115 0.1754 0.1719
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0723 0.0697
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0036 0.0291 0.1737
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.007 0.092 0.09
Giardia lamblia Alanyl dipeptidyl peptidase 0.007 0.092 0.5
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0036 0.0291 0.0299
Loa Loa (eye worm) MBCTL1 0.0053 0.0607 0.0623
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Plasmodium falciparum plasmepsin VI 0.0059 0.0728 0.4698
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.007 0.092 0.0944
Trypanosoma brucei prolyl endopeptidase 0.0547 0.9745 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0102 0.1514 0.1524
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0547 0.9745 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0947 0.0972
Schistosoma mansoni calpain-7 (C02 family) 0.004 0.0374 0.0383
Loa Loa (eye worm) TATA binding protein associated factor 0.0036 0.0291 0.0299
Echinococcus granulosus calpain 5 0.004 0.0374 0.0349
Toxoplasma gondii ABC1 family protein 0.0071 0.0947 0.0929
Echinococcus multilocularis calpain 5 0.004 0.0374 0.0349
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0947 0.1084
Mycobacterium tuberculosis Conserved protein 0.0071 0.0947 0.1084
Echinococcus granulosus Dipeptidyl peptidase 9 0.0115 0.1754 0.1771
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0547 0.9745 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.007 0.092 0.5138
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.0728 0.0714
Toxoplasma gondii aminopeptidase n, putative 0.0036 0.0291 0.0252
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.004 0.0374 0.0288
Brugia malayi Ets-domain containing protein 0.0073 0.0971 0.0929
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0059 0.0728 0.3573
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0263 0.4486 0.4603
Loa Loa (eye worm) aspartyl protease 6 0.0023 0.0046 0.0048
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0115 0.1754 0.1771
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0947 0.1084
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0607 0.0623
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0226 0.3806 0.448
Brugia malayi hypothetical protein 0.0045 0.0463 0.0418
Loa Loa (eye worm) hypothetical protein 0.0036 0.0291 0.0299
Trypanosoma brucei Aminopeptidase M1, putative 0.0102 0.1514 0.147
Trichomonas vaginalis conserved hypothetical protein 0.007 0.092 0.5138
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.0728 0.0714
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0115 0.1754 0.1771
Entamoeba histolytica aminopeptidase, putative 0.0102 0.1514 1
Trypanosoma cruzi aminopeptidase, putative 0.0102 0.1514 0.1523
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0066 0.0851 0.084
Trypanosoma cruzi oligopeptidase b 0.0226 0.3806 0.3884
Trypanosoma brucei calpain-like protein, putative 0.004 0.0374 0.0288
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0232 0.391 0.4013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0453 0.0464
Onchocerca volvulus Prolyl endopeptidase homolog 0.0547 0.9745 1
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0115 0.1754 0.1719
Leishmania major hypothetical protein, conserved 0.0071 0.0947 0.094
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Mycobacterium ulcerans lipase LipD 0.0071 0.0947 0.2419
Brugia malayi Peptidase family M1 containing protein 0.0346 0.6036 0.6017
Loa Loa (eye worm) hypothetical protein 0.0066 0.0851 0.0873
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0971 0.0996
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0488 0.0467
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0947 0.2419
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0947 0.1084
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0098 0.1447 0.1454
Trypanosoma brucei calpain-like protein, putative 0.004 0.0374 0.0288
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0066 0.0851 0.0873
Loa Loa (eye worm) calpain family protein 1 0.0107 0.1605 0.1647
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0098 0.1447 0.1454
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0036 0.0291 0.0264
Toxoplasma gondii hypothetical protein 0.007 0.092 0.09
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0723 0.0709
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0723 0.0742
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0112 0.1694 0.1739
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0704 0.069
Trypanosoma brucei calpain-like protein, putative 0.004 0.0374 0.0288
Brugia malayi Peptidase family M1 containing protein 0.0102 0.1514 0.1475
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0477 0.8454 1
Onchocerca volvulus 0.0071 0.0947 0.0929
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Schistosoma mansoni bromodomain containing protein 0.0062 0.0769 0.0789
Brugia malayi hypothetical protein 0.0102 0.1514 0.1475
Loa Loa (eye worm) subtilase 0.0263 0.4486 0.4603
Loa Loa (eye worm) fli-1 protein 0.022 0.3705 0.3802
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0488 0.0467
Entamoeba histolytica prolyl oligopeptidase family protein 0.007 0.092 0.5643
Plasmodium falciparum peptidase, putative 0.007 0.092 0.5995
Mycobacterium ulcerans beta-lactamase 0.0071 0.0947 0.2419
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0947 0.5364
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Trypanosoma cruzi kinesin, putative 0.0028 0.015 0.0118
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0226 0.3806 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0453 0.0464
Loa Loa (eye worm) hypothetical protein 0.0095 0.1381 0.1417
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0488 0.0501
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Loa Loa (eye worm) calpain 0.004 0.0374 0.0383
Brugia malayi beta-lactamase family protein 0.0071 0.0947 0.0905
Loa Loa (eye worm) aminopeptidase N 0.0102 0.1514 0.1554
Onchocerca volvulus 0.0036 0.0291 0.0252
Loa Loa (eye worm) hypothetical protein 0.0071 0.0947 0.0972
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0036 0.0291 0.0264
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0226 0.3806 0.3884
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0291 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0453 0.0431
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0115 0.1754 0.18
Brugia malayi prolyl oligopeptidase family protein 0.007 0.092 0.0877
Echinococcus multilocularis acylamino acid releasing enzyme 0.007 0.092 0.0912
Entamoeba histolytica prolyl oligopeptidase family protein 0.007 0.092 0.5643
Brugia malayi Ets-domain containing protein 0.0073 0.0971 0.0929
Echinococcus multilocularis calpain 7 (C02 family) 0.004 0.0374 0.0349
Loa Loa (eye worm) hypothetical protein 0.0244 0.4149 0.4258
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0102 0.1514 0.1524
Trypanosoma brucei oligopeptidase b 0.0226 0.3806 0.3846
Loa Loa (eye worm) hypothetical protein 0.0042 0.0397 0.0407
Leishmania major oligopeptidase b 0.0226 0.3806 0.3884
Trypanosoma brucei aminopeptidase, putative 0.0036 0.0291 0.0203
Loa Loa (eye worm) peptidase family M1 containing protein 0.028 0.4813 0.4938
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.1514 0.1523
Trichomonas vaginalis esterase, putative 0.0071 0.0947 0.5364
Toxoplasma gondii prolyl endopeptidase 0.0547 0.9745 1
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0488 0.0467
Brugia malayi prolyl oligopeptidase family protein 0.0547 0.9745 0.9744
Loa Loa (eye worm) hypothetical protein 0.0036 0.0291 0.0299
Plasmodium vivax hypothetical protein, conserved 0.007 0.092 0.5964
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0374 0.0349
Mycobacterium ulcerans hypothetical protein 0.0071 0.0947 0.2419
Plasmodium vivax plasmepsin IV, putative 0.0059 0.0728 0.4656
Schistosoma mansoni P2X receptor subunit 0.0067 0.0869 0.0891
Schistosoma mansoni cathepsin D (A01 family) 0.0246 0.4176 0.4285
Onchocerca volvulus 0.0346 0.6036 0.6175
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0723 0.0817
Trypanosoma cruzi kinesin, putative 0.0028 0.015 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0947 0.1084
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0115 0.1754 0.1771
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.0728 0.0747
Echinococcus granulosus calpain A 0.004 0.0374 0.0349
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.007 0.092 0.5138
Loa Loa (eye worm) calpain 5 0.0028 0.015 0.0153
Toxoplasma gondii aspartyl protease ASP3 0.0102 0.1511 0.151
Loa Loa (eye worm) hypothetical protein 0.0045 0.0463 0.0475
Toxoplasma gondii aminopeptidase N protein 0.0036 0.0291 0.0252
Brugia malayi calpain family protein 1 0.0107 0.1605 0.1566
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0232 0.391 0.3991
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0947 0.5364
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0023 0.0046 0.0048
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0276 0.0249
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0488 0.0501
Loa Loa (eye worm) hypothetical protein 0.0069 0.0903 0.0927
Loa Loa (eye worm) prolyl oligopeptidase 0.007 0.092 0.0944
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0183 0.3016 0.3071
Loa Loa (eye worm) hypothetical protein 0.0311 0.5372 0.5513
Loa Loa (eye worm) hypothetical protein 0.007 0.092 0.0944
Loa Loa (eye worm) hypothetical protein 0.0037 0.032 0.0328
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0059 0.0728 0.0747
Brugia malayi Bromodomain containing protein 0.0073 0.098 0.0938
Schistosoma mansoni calpain (C02 family) 0.004 0.0374 0.0383
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0036 0.0291 0.0299
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0947 0.1084
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0869 0.0859
Plasmodium falciparum plasmepsin IX 0.0102 0.1511 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0048
Loa Loa (eye worm) hypothetical protein 0.0071 0.0947 0.0972
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0607 0.059
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0232 0.391 0.3991
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0036 0.0291 0.0299
Plasmodium falciparum plasmepsin IV 0.0059 0.0728 0.4698
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0374 0.0349
Brugia malayi calpain 5 0.0028 0.015 0.0104
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0349
Schistosoma mansoni P2X receptor subunit 0.0067 0.0869 0.0891
Plasmodium falciparum plasmepsin V 0.0023 0.0046 0.0078
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0947 0.0972
Brugia malayi MH2 domain containing protein 0.0241 0.4088 0.406
Schistosoma mansoni P2X receptor subunit 0.0067 0.0869 0.0891
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0488 0.0501
Plasmodium falciparum plasmepsin VII 0.0023 0.0046 0.0078
Echinococcus multilocularis p2X purinoceptor 4 0.0067 0.0869 0.0859
Onchocerca volvulus 0.0046 0.0488 0.0455
Schistosoma mansoni calpain C (C02 family) 0.004 0.0374 0.0383
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0453 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.004 0.0374 0.0288
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.004 0.0374 0.0349
Trypanosoma cruzi calpain cysteine peptidase, putative 0.004 0.0374 0.0349
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0226 0.3806 0.3884
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0488 0.0501
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0869 0.0859
Brugia malayi calpain 7 0.004 0.0374 0.0329
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0102 0.1514 0.1523
Echinococcus multilocularis calpain 0.004 0.0374 0.0349
Loa Loa (eye worm) hypothetical protein 0.0023 0.0046 0.0048
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0869 0.0859
Brugia malayi calpain family protein 1 0.0107 0.1605 0.1566
Loa Loa (eye worm) hypothetical protein 0.0079 0.1083 0.1112
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0226 0.3806 0.3846
Mycobacterium tuberculosis Conserved protein 0.0071 0.0947 0.1084
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.0291 0.0264
Toxoplasma gondii aminopeptidase N, putative 0.0036 0.0291 0.0252
Brugia malayi beta-lactamase 0.0071 0.0947 0.0905
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0102 0.1514 0.147
Brugia malayi TATA binding protein associated factor 0.0036 0.0291 0.0246
Leishmania major hypothetical protein, conserved 0.0025 0.0095 0.0062
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0547 0.9745 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0036 0.0291 0.1672
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0276 0.0249
Treponema pallidum mcbG protein 0.0022 0.0035 0.5
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.0291 0.0264
Brugia malayi prolyl oligopeptidase family protein 0.0232 0.391 0.3882
Loa Loa (eye worm) hypothetical protein 0.0046 0.0488 0.0501
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0098
Brugia malayi hypothetical protein 0.0036 0.0291 0.0246
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0095 0.041
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.1514 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0859 0.0882
Echinococcus granulosus calpain A 0.0112 0.1694 0.1709
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0947 0.0972
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0947 0.094
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0034 0.0035
Trypanosoma brucei calpain-like protein, putative 0.004 0.0374 0.0288
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0291 0.0264
Brugia malayi Subtilase family protein 0.0263 0.4486 0.446
Loa Loa (eye worm) hypothetical protein 0.0036 0.0291 0.0299
Brugia malayi PHD-finger family protein 0.0024 0.0077 0.0031
Plasmodium falciparum plasmepsin II 0.0059 0.0728 0.4698
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0488 0.0455
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0095 0.0335
Onchocerca volvulus 0.0071 0.0947 0.0929
Loa Loa (eye worm) beta-lactamase 0.0071 0.0947 0.0972
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0453 0.0408
Schistosoma mansoni cathepsin D (A01 family) 0.0246 0.4176 0.4285
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0607 0.059
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0023 0.0046 0.0048
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0102 0.1514 0.1554
Echinococcus granulosus prolyl endopeptidase 0.0547 0.9745 1
Loa Loa (eye worm) calpain family protein 1 0.0079 0.1083 0.1112
Schistosoma mansoni ets-related 0.022 0.3705 0.3802
Trypanosoma cruzi oligopeptidase b 0.0226 0.3806 0.3884
Leishmania major kinesin, putative 0.0028 0.015 0.0118
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.8056 0.9528
Loa Loa (eye worm) hypothetical protein 0.0071 0.0947 0.0972
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.0728 0.4656
Onchocerca volvulus 0.0071 0.0947 0.0929
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0102 0.1514 1
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0971 0.0964
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0036 0.0291 0.1737
Entamoeba histolytica dipeptidyl-peptidase, putative 0.007 0.092 0.5643
Brugia malayi prolyl oligopeptidase family protein 0.007 0.092 0.0877
Schistosoma mansoni memapsin-2 (A01 family) 0.0023 0.0046 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0453 0.0464
Echinococcus granulosus p2X purinoceptor 4 0.0067 0.0869 0.0859
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.007 0.092 0.0854
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0291 0.0264
Entamoeba histolytica prolyl oligopeptidase family protein 0.007 0.092 0.5643
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0947 0.2419
Plasmodium vivax calpain, putative 0.004 0.0374 0.2235
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0971 0.0964
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0947 0.5364

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 2.3 nM Inhibitory constant against cloned human Gonadotropin-releasing hormone receptor stably expressed in HEK293 cells was determined ChEMBL. 15664839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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