Detailed information for compound 954329

Basic information

Technical information
  • TDR Targets ID: 954329
  • Name: 3-hydroxy-1,2-bis(4-hydroxy-3-methoxyphenyl)p ropan-1-one
  • MW: 318.321 | Formula: C17H18O6
  • H donors: 3 H acceptors: 4 LogP: 1.78 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(C(=O)c1ccc(c(c1)OC)O)c1ccc(c(c1)OC)O
  • InChi: 1S/C17H18O6/c1-22-15-7-10(3-5-13(15)19)12(9-18)17(21)11-4-6-14(20)16(8-11)23-2/h3-8,12,18-20H,9H2,1-2H3
  • InChiKey: QMYGRGKKZBRZKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-hydroxy-1,2-bis(4-hydroxy-3-methoxy-phenyl)propan-1-one
  • Evofolin B

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0023 0.097
Echinococcus granulosus geminin 0.0843 0.2034 0.3757
Brugia malayi acetyltransferase, GNAT family protein 0.0311 0.0737 0.1156
Onchocerca volvulus 0.0024 0.0037 0.0063
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0003 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0215 0.0323
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0072 0.0155 0.2844
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0314 0.0313
Echinococcus multilocularis mothers against decapentaplegic 6 0.0011 0.0005 0.0004
Brugia malayi MH2 domain containing protein 0.0024 0.0037 0.0056
Brugia malayi nuclear hormone receptor 0.0021 0.003 0.0045
Onchocerca volvulus 0.0024 0.0037 0.0063
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0029 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Schistosoma mansoni DNA ligase IV 0.001 0.0003 0.0003
Schistosoma mansoni inositol transporter 0.0037 0.007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi MH1 domain containing protein 0.0024 0.0037 0.0056
Brugia malayi Sodium:solute symporter family protein 0.0037 0.007 0.0107
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Echinococcus multilocularis sterol regulatory element binding protein 0.0169 0.039 0.0389
Giardia lamblia Histone acetyltransferase GCN5 0.0084 0.0183 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0048 0.075
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0047 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi nuclear receptor NHR-88 0.001 0.0003 0.0003
Loa Loa (eye worm) transcription factor SMAD2 0.0351 0.0835 0.1311
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0096 0.0213 0.0332
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.0707 0.1109
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0003 0.0002
Brugia malayi conserved hypotetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0045
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0001 0.0000029975
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0038 0.0561
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0003 0.0003
Plasmodium vivax SET domain containing protein 0.0011 0.0004 0.0088
Onchocerca volvulus 0.0035 0.0064 0.0113
Brugia malayi ecdysone receptor 0.001 0.0003 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.003 0.0053
Echinococcus multilocularis Niemann Pick C1 protein 0.0393 0.0937 0.0936
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Onchocerca volvulus 0.0063 0.0132 0.0239
Schistosoma mansoni Smad4 0.0024 0.0037 0.0066
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0037 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0314 0.0578
Toxoplasma gondii exonuclease III APE 0.0018 0.0023 0.1035
Brugia malayi hypothetical protein 0.001 0.0003 0.0003
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0028 0.0048 0.2141
Brugia malayi TAR-binding protein 0.0127 0.0289 0.0453
Mycobacterium tuberculosis Conserved protein 0.0035 0.0064 0.1054
Echinococcus multilocularis snurportin 1 0.0299 0.0707 0.0706
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0037 0.0056
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0048 0.075
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0048 0.2284
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.003 0.0053
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Schistosoma mansoni ferritin light chain 0.0026 0.0041 0.0074
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0041 0.0618
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0003 0.0002
Schistosoma mansoni nuclear receptor 0.001 0.0003 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0289 0.0288
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0068 0.0105
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus granulosus Niemann Pick C1 protein 0.0562 0.1348 0.2488
Echinococcus multilocularis Niemann Pick C1 protein 0.0562 0.1348 0.1347
Echinococcus granulosus GPCR family 2 0.0096 0.0213 0.0391
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0091 0.0202 1
Echinococcus granulosus ferritin 0.0026 0.0041 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0064 0.2875
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0132 0.0131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0255 0.06 0.1107
Onchocerca volvulus 0.0028 0.0048 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0155 0.7188
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0045
Mycobacterium ulcerans hypothetical protein 0.0097 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus Protein patched homolog 0.0024 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0005 0.0006
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0064 0.1054
Plasmodium vivax SET domain protein, putative 0.0063 0.0132 0.65
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.001 0.0009
Entamoeba histolytica hypothetical protein 0.0023 0.0034 0.0336
Loa Loa (eye worm) hypothetical protein 0.0013 0.0011 0.0015
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0003 0.0003
Echinococcus multilocularis smad 0.0024 0.0037 0.0036
Brugia malayi mothers against decapentaplegic homolog 3 0.0011 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0047 0.007
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.007 0.0126
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0072 0.0155 1
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi ERG2 and Sigma1 receptor like protein 0.2619 0.6362 1
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0037 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0011 0.0005 0.0006
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0064 0.0537
Onchocerca volvulus 0.0035 0.0064 0.0113
Trichomonas vaginalis ferritin, putative 0.0026 0.0041 0.0349
Brugia malayi Latrophilin receptor protein 2 0.0096 0.0213 0.0332
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0028 0.0048 0.2141
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.007 0.0126
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0215 0.0323
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0041 0.1824
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni topbp1 0.001 0.0003 0.0003
Leishmania major GTP-binding protein, putative 0.0021 0.0029 0.003
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0034 0.0287
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0169 0.039 0.0611
Echinococcus granulosus importin subunit beta 1 0.0028 0.0047 0.0085
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.003 0.0053
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0064 0.0098
Echinococcus granulosus tar DNA binding protein 0.0127 0.0289 0.0532
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.001 0.0394
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.0215 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0064 0.0537
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0023 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0045
Brugia malayi Calcitonin receptor-like protein seb-1 0.0303 0.0718 0.1126
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0097 0.0215 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0028 0.0048 0.2141
Brugia malayi nuclear receptor NHR-67 0.001 0.0003 0.0003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0314 0.0578
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0003 0.0001
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0005
Schistosoma mansoni Smad4 0.0011 0.0005 0.0007
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0041 0.1824
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.001 0.1839
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0003 0.0003
Onchocerca volvulus 0.0028 0.0048 0.0084
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.001 0.0013
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0215 0.0336
Onchocerca volvulus 0.001 0.0003 0.0001
Brugia malayi protein C24B5.3 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0207 0.0484 0.0759
Onchocerca volvulus 0.0024 0.0037 0.0063
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0183 0.3384
Echinococcus multilocularis expressed conserved protein 0.0369 0.0879 0.0878
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0289 0.0453
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Leishmania major 4-coumarate:coa ligase-like protein 0.0097 0.0215 0.0323
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.001 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0132 0.0242
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0023 0.532
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0023 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.0521 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0028 0.0048 0.2141
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0064 0.2875
Brugia malayi Patched protein homolog 1 0.0024 0.0037 0.0056
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0215 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.003 0.0053
Brugia malayi CHE-14 protein 0.0169 0.039 0.0611
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.003 0.0053
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0003 0.0002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.1458
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0047 0.2227
Echinococcus granulosus sterol regulatory element binding protein 0.0169 0.039 0.0718
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.001 0.1839
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0215 0.0336
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Loa Loa (eye worm) hypothetical protein 0.0028 0.0047 0.0072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0096 0.0213 0.0332
Echinococcus multilocularis solute carrier family 5 0.0037 0.007 0.0068
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi hypothetical protein 0.001 0.0003 0.0002
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0132 0.0242
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0048 0.0406
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0169 0.039 0.0611
Trichomonas vaginalis ran, putative 0.0021 0.0029 0.0244
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0125 0.0229
Brugia malayi Pre-SET motif family protein 0.0063 0.0132 0.0206
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0068 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0064 0.0096
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.003 0.0053
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.001 0.0335
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0023 0.0032
Schistosoma mansoni ferritin light chain 0.0026 0.0041 0.0074
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0041 0.0618
Brugia malayi CXXC zinc finger family protein 0.0028 0.0047 0.0072
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0068 0.1143
Brugia malayi protein C24B5.3 0.0024 0.0037 0.0056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0064 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0041
Loa Loa (eye worm) glutathione reductase 0.0037 0.0068 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus granulosus FTZ F1 alpha 0.0021 0.003 0.0053
Plasmodium falciparum importin beta, putative 0.0028 0.0047 0.2456
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi beta-lactamase family protein 0.0035 0.0064 0.0098
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0064 0.2875
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0096 0.0213 0.0211
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0003 0.0003
Plasmodium falciparum thioredoxin reductase 0.0013 0.001 0.0394
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0022
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0008
Plasmodium vivax importin-beta 2, putative 0.0028 0.0047 0.2227
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0048 0.0074
Brugia malayi Nuclear hormone receptor E75 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi MH1 domain containing protein 0.0013 0.0011 0.0015
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2619 0.6362 1
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.0045
Brugia malayi nuclear receptor RXR 0.0011 0.0006 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0064 0.0096
Leishmania major hypothetical protein, conserved 0.0035 0.0064 0.0085
Brugia malayi Patched related family protein 4 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0003 0.0001
Echinococcus granulosus cpg binding protein 0.0029 0.0051 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.003 0.0045
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0183 0.3384
Brugia malayi vesicular acetylcholine transporter unc-17 0.2229 0.5413 0.8507
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0028 0.0048 0.2141
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.0029
Brugia malayi hypothetical protein 0.0255 0.06 0.0942
Schistosoma mansoni coup transcription factor 0.0021 0.003 0.0053
Echinococcus multilocularis high affinity choline transporter 1 0.0338 0.0802 0.0801
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0028 0.0048 0.2141
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Schistosoma mansoni cpg binding protein 0.0029 0.0051 0.0091
Echinococcus granulosus solute carrier family 5 0.0037 0.007 0.0126
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.003 0.0053
Echinococcus multilocularis vesicular acetylcholine transporter 0.2229 0.5413 0.5412
Echinococcus multilocularis Smad4 0.0024 0.0037 0.0036
Brugia malayi MH2 domain containing protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2229 0.5413 0.8507
Leishmania major trypanothione reductase 0.0037 0.0068 0.0092
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0064 0.0537
Brugia malayi Importin beta-1 subunit 0.0028 0.0047 0.0072
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Echinococcus granulosus expressed conserved protein 0.0369 0.0879 0.1621
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0003 0.0022
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0289 0.0453
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0023 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Echinococcus granulosus smad 0.0024 0.0037 0.0066
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.001 0.0358
Brugia malayi Pre-SET motif family protein 0.0435 0.1038 0.1631
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.003 0.0045
Echinococcus multilocularis ferritin 0.0026 0.0041 0.004
Brugia malayi beta-lactamase 0.0035 0.0064 0.0098
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Brugia malayi hypothetical protein 0.001 0.0003 0.0002
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Plasmodium falciparum acyl-CoA synthetase 0.0072 0.0155 0.8456
Schistosoma mansoni high-affinity choline transporter 0.0338 0.0802 0.148
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Echinococcus multilocularis GPCR, family 2 0.0096 0.0213 0.0211
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.001 0.0394
Loa Loa (eye worm) nuclear factor I 0.0013 0.0011 0.0015
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.001 0.0335
Loa Loa (eye worm) hypothetical protein 0.0207 0.0482 0.0756
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0023 0.1141
Plasmodium vivax acyl-CoA synthetase, putative 0.0072 0.0155 0.7667
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.0053
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0011 0.0005 0.0004
Loa Loa (eye worm) DR-78 0.001 0.0003 0.0003
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0005 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0053
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0215 1
Plasmodium falciparum thioredoxin reductase 0.0037 0.0068 0.3635
Loa Loa (eye worm) hypothetical protein 0.1338 0.3241 0.5094
Plasmodium falciparum glutathione reductase 0.0013 0.001 0.0394
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.007 0.0126
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0064 0.1054
Mycobacterium tuberculosis Conserved protein 0.0035 0.0064 0.1054
Trichomonas vaginalis conserved hypothetical protein 0.0169 0.039 0.3291
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0096 0.0213 0.0391
Echinococcus granulosus vesicular acetylcholine transporter 0.2229 0.5413 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0351 0.0835 0.1311
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0064 0.3066
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0206 0.383
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi nuclear receptor RXR 0.001 0.0003 0.0003
Trichomonas vaginalis esterase, putative 0.0035 0.0064 0.0537
Mycobacterium ulcerans lipase LipD 0.0035 0.0064 0.2875
Brugia malayi MH1 domain containing protein 0.0013 0.0011 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0048 0.075
Loa Loa (eye worm) hypothetical protein 0.0338 0.0802 0.1259
Schistosoma mansoni smad 0.0024 0.0037 0.0066
Schistosoma mansoni zinc finger protein 0.001 0.0003 0.0003
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.003 0.0045
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0314 0.0492
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.003 0.0045
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0037 0.0036
Loa Loa (eye worm) hypothetical protein 0.0037 0.007 0.0107
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni hypothetical protein 0.0255 0.06 0.1107
Schistosoma mansoni ran 0.0021 0.0029 0.0051
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0393 0.0937 0.1471
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0029 0.0028
Brugia malayi DKFZp564C0469 protein 0.001 0.0003 0.0002
Brugia malayi Thioredoxin reductase 0.0037 0.0068 0.0105
Entamoeba histolytica acetyltransferase, GNAT family 0.0084 0.0183 0.1932
Entamoeba histolytica acyl-coA synthetase, putative 0.0097 0.0215 0.2273
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.003 0.0045
Schistosoma mansoni vesicular acetylcholine transporter 0.2229 0.5413 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.0029
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Loa Loa (eye worm) hypothetical protein 0.0063 0.0132 0.0206
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0206 0.383
Plasmodium vivax patched family protein, putative 0.0024 0.0037 0.1718
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus 0.0024 0.0037 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0011
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0048 0.2141
Echinococcus granulosus replication factor c subunit 1 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0215 1
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0003 0.0003
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.0071
Brugia malayi RNA binding protein 0.0127 0.0289 0.0453
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.0074
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi nuclear hormone receptor 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0064 0.1054
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) Smad1 0.0024 0.0037 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Brugia malayi glutathione reductase 0.0037 0.0068 0.0105
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi Niemann-Pick C1 protein precursor 0.0393 0.0937 0.1471
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0048 0.0074
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.001 0.0358
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.007 0.0068
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0003 0.0003
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0003 0.0003
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0048 0.2141
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0006 0.0009
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Schistosoma mansoni hypothetical protein 0.0843 0.2034 0.3757
Plasmodium falciparum glutathione reductase 0.0037 0.0068 0.3635
Onchocerca volvulus 0.0037 0.007 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0045
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0129 0.0235
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.003 0.0053
Brugia malayi GH02984p 0.0338 0.0802 0.1259
Schistosoma mansoni patched 1 0.0169 0.039 0.0718
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.0044
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0048 0.2284
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0097 0.0215 1
Onchocerca volvulus 0.0024 0.0037 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Echinococcus granulosus nibrin 0.001 0.0003 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0289 0.0453
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0045
Brugia malayi MH2 domain containing protein 0.0011 0.0005 0.0006
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0064 0.0115
Schistosoma mansoni topbp1 0.001 0.0003 0.0003
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.007 0.0068
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni ran 0.0021 0.0029 0.0051
Schistosoma mansoni cpg binding protein 0.0028 0.0047 0.0084
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0041 1
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.001 0.0082
Loa Loa (eye worm) hypothetical protein 0.2619 0.6362 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.001 0.0016
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Mycobacterium tuberculosis Probable reductase 0.0084 0.0183 0.3384
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0096 0.0213 0.0211
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.0053
Plasmodium falciparum lipid/sterol:H+ symporter 0.0024 0.0037 0.1895
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0096 0.0213 0.0332
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0000055386
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.007 0.3363
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0183 0.3384
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0215 0.2273
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0255 0.06 0.0599
Toxoplasma gondii thioredoxin reductase 0.0037 0.0068 0.3296
Treponema pallidum NADH oxidase 0.0013 0.001 0.1839
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.003 0.0045
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0003 0.0002
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0048 0.0047
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0034 0.0049
Brugia malayi Myosin head containing protein 0.0024 0.0037 0.0056
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0003 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Schistosoma mansoni smad1 5 8 and 0.0024 0.0037 0.0066
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0183 0.3384
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.0053
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0132 0.65
Onchocerca volvulus 0.0035 0.0064 0.0113
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0048 0.006
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.001 0.0011
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0311 0.0737 0.0736
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0206 0.383
Loa Loa (eye worm) acetyltransferase 0.0311 0.0737 0.1156
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.003 0.0051
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0003 0.0003
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0311 0.0737 0.1359
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0399 0.0952 0.1756
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.001 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0132 0.0242
Echinococcus granulosus Smad4 0.0024 0.0037 0.0066
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0393 0.0937 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0023 0.0022
Schistosoma mansoni Smad4 0.0011 0.0005 0.0007
Schistosoma mansoni sodium/solute symporter 0.0037 0.007 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0007
Leishmania major C-8 sterol isomerase-like protein 0.2619 0.6362 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0064 0.1054
Schistosoma mansoni cpg binding protein 0.0029 0.0051 0.0091
Echinococcus multilocularis protein dispatched 1 0.0192 0.0448 0.0447
Echinococcus granulosus histone acetyltransferase KAT2B 0.0302 0.0715 0.132
Loa Loa (eye worm) beta-lactamase 0.0035 0.0064 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0001 0.0000055386
Loa Loa (eye worm) hypothetical protein 0.0028 0.0048 0.0074
Echinococcus multilocularis expressed protein 0.0026 0.0041 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0064 0.0115
Brugia malayi Patched related family protein 10 0.0024 0.0037 0.0056
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0048 0.2284
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0003 0.0022
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.0071
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0064 0.0062
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.0041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0314 0.0492
Onchocerca volvulus 0.0028 0.0048 0.0084
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0048 0.075
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0314 0.0313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0029 0.1322
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0048 0.0087
Schistosoma mansoni importin beta-1 0.0028 0.0047 0.0085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0183 0.3384
Echinococcus multilocularis mothers against decapentaplegic 2 0.0011 0.0005 0.0004
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0091 0.0202 1
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.001 0.0011
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0048 0.075
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Brugia malayi hypothetical protein 0.0024 0.0037 0.0056
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Echinococcus granulosus Protein patched homolog 1 0.0169 0.039 0.0718
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0097 0.0215 1
Brugia malayi RNA, U transporter 1 0.008 0.0173 0.027
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0196
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0023 0.0221
Onchocerca volvulus 0.0024 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus granulosus snurportin 1 0.0299 0.0707 0.1304
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.0041
Echinococcus multilocularis cpg binding protein 0.0029 0.0051 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Brugia malayi topoisomerase 0.001 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.003 0.0053
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0023 0.1141
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Mycobacterium ulcerans acetyl-CoA synthetase 0.0028 0.0048 0.2141
Mycobacterium tuberculosis Conserved protein 0.0035 0.0064 0.1054
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.003 0.0029
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0096 0.0213 0.0391
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.007 0.0068
Brugia malayi Nuclear hormone receptor E75 0.001 0.0003 0.0003
Trichomonas vaginalis set domain proteins, putative 0.0495 0.1185 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0003 0.0003
Echinococcus multilocularis geminin 0.0843 0.2034 0.2033
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.003 0.0053
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0041 0.1824
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0097 0.0215 0.4011
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Trichomonas vaginalis bromodomain-containing protein, putative 0.0091 0.0202 0.1702
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0163 0.0375 0.0691
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.001 0.0467
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.003 0.0053
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.1458
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0003
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0041
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0003 0.0002
Schistosoma mansoni nuclear receptor 0.001 0.0003 0.0003
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Schistosoma mansoni inositol transporter 0.0037 0.007 0.0126
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0069 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0045
Echinococcus granulosus mothers against decapentaplegic 2 0.0011 0.0005 0.0007
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.001 0.0335
Brugia malayi MH2 domain containing protein 0.0351 0.0835 0.1311
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0132 0.6488
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0037 0.0056
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0002 0.0001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0006 0.0009
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0037 0.0066
Schistosoma mansoni smad1 5 8 and 0.0024 0.0037 0.0066
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0029 0.1322
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.001 0.0016
Schistosoma mansoni apoferritin-2 0.0026 0.0041 0.0074
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.001 0.0358
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0064 0.1054
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0006 0.0007
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0003 0.0000036781
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0196
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0048 0.075
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0045
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0068 0.3296
Loa Loa (eye worm) hypothetical protein 0.0097 0.0215 0.0336
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0029 0.0041
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0002
Mycobacterium ulcerans hypothetical protein 0.0035 0.0064 0.2875
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0068 0.0146 0.2656
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0314 0.0578
Toxoplasma gondii ABC1 family protein 0.0035 0.0064 0.3066
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.001 0.0011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0023 0.0032
Schistosoma mansoni smad 0.0011 0.0005 0.0007
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0048 0.0071
Loa Loa (eye worm) oxidoreductase 0.0028 0.0048 0.0074
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0048 0.075
Schistosoma mansoni transcription factor LCR-F1 0.0255 0.06 0.1107
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0006 0.0007
Entamoeba histolytica hypothetical protein 0.0255 0.06 0.6397
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0006 0.0009
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.075
Schistosoma mansoni nuclear hormone receptor 0.001 0.0003 0.0003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.0029
Brugia malayi hypothetical protein 0.0011 0.0006 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.0053
Trypanosoma brucei trypanothione reductase 0.0037 0.0068 0.0103
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.001 0.0082
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.003 0.0051
Brugia malayi tailless protein 0.001 0.0003 0.0003
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0048 0.006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0023 0.1035
Mycobacterium ulcerans beta-lactamase 0.0035 0.0064 0.2875
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.0045
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0064 0.1054
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.003 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0435 0.1038 0.1631
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0048 0.0071
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0206 0.9562
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0048 0.0406
Brugia malayi latrophilin 2 splice variant baaae 0.0207 0.0484 0.0759
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0002 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0393 0.0937 0.1729
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0003 0.0003
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0097 0.0215 1
Brugia malayi MH1 domain containing protein 0.0024 0.0037 0.0056
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2229 0.5413 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0048 0.0074
Loa Loa (eye worm) hypothetical protein 0.0303 0.0718 0.1126
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.003 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.003 0.0045
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0028 0.0048 0.2141
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.001 0.0394
Onchocerca volvulus 0.0028 0.0048 0.0084
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Onchocerca volvulus 0.0028 0.0047 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.0045
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0064 0.0098
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0041 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0289 0.0532
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0287
Echinococcus granulosus high affinity choline transporter 1 0.0338 0.0802 0.148
Schistosoma mansoni smad1 5 8 and 0.0024 0.0037 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0303 0.0718 0.1126
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0064 0.0096
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0048 0.2519
Loa Loa (eye worm) MH1 domain-containing protein 0.0011 0.0005 0.0006
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0006 0.0007
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0069 0.0126
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.001 0.0011
Trypanosoma brucei C-8 sterol isomerase, putative 0.2619 0.6362 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0001 0.0000029975
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0037 0.0066
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0314 0.0578
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0048 0.0071
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0003 0.0003
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0003 0.0022
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0303 0.0718 0.1126
Schistosoma mansoni nuclear hormone receptor 0.0021 0.003 0.0053
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0064 0.1054
Schistosoma mansoni thyroid hormone receptor 0.0021 0.003 0.0053
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0048 0.0071
Brugia malayi ecdysteroid receptor 0.0021 0.003 0.0045
Brugia malayi hypothetical protein 0.001 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Brugia malayi steroid hormone receptor 0.0021 0.003 0.0045
Onchocerca volvulus 0.0097 0.0215 0.0392
Schistosoma mansoni hypothetical protein 0.0207 0.0484 0.0892
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0132 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0097 0.0215 0.0336
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0091 0.0202 0.1702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.003 0.0045
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0091 0.0202 1
Brugia malayi hypothetical protein 0.0011 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0003 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0005 0.0004
Plasmodium vivax glutathione reductase, putative 0.0037 0.0068 0.3296
Schistosoma mansoni hypothetical protein 0.0843 0.2034 0.3757
Mycobacterium ulcerans acyl-CoA synthetase 0.0097 0.0215 1
Echinococcus multilocularis nibrin 0.001 0.0003 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0097 0.0215 0.2273
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0028 0.0048 0.2141
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.001 0.0011
Schistosoma mansoni apoferritin-2 0.0026 0.0041 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.003 0.0045
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.0053
Entamoeba histolytica Ran family GTPase 0.0021 0.0029 0.0282
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0003 0.0022
Brugia malayi Patched family protein 0.0024 0.0037 0.0056
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0001 0.0000055386
Leishmania major importin beta-1 subunit, putative 0.0023 0.0034 0.0038
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0183 0.8489
Onchocerca volvulus 0.0495 0.1185 0.2185
Onchocerca volvulus 0.0021 0.003 0.0051
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0003 0.0003
Loa Loa (eye worm) RNA binding protein 0.0127 0.0289 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0314 0.0578
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Loa Loa (eye worm) patched family protein 0.0024 0.0037 0.0056
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0028 0.0048 0.2141
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0034 0.0287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.0045
Echinococcus granulosus mothers against decapentaplegic 6 0.0011 0.0005 0.0007
Onchocerca volvulus Protein patched homolog 0.0024 0.0037 0.0063
Echinococcus granulosus histone acetyltransferase KAT2B 0.0091 0.0202 0.037
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0132 0.0242
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Brugia malayi beta-lactamase family protein 0.0035 0.0064 0.0098
Echinococcus multilocularis protein patched 0.0169 0.039 0.0389
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0064 0.0537
Brugia malayi Smad1 0.0024 0.0037 0.0056
Mycobacterium leprae Probable lipase LipE 0.0035 0.0064 0.2875
Onchocerca volvulus 0.001 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0299 0.0707 0.1304
Plasmodium falciparum histone acetyltransferase GCN5 0.0084 0.0183 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0003 0.0003
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0023 0.532
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0048 0.0087
Echinococcus granulosus expressed protein 0.0026 0.0041 0.0074
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0048 0.2284
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.007 0.0126
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0047 0.0072
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0048 0.0487
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0003 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.003 0.0045
Schistosoma mansoni ferritin 0.0026 0.0041 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0003 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0132 0.0242
Loa Loa (eye worm) hypothetical protein 0.0097 0.0215 0.0336
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0005 0.0007
Brugia malayi Patched related family protein 12 0.0024 0.0037 0.0056
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.003 0.0029
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0047 0.007
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0215 0.4011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0064 0.0537
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0029 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0064 0.0098
Toxoplasma gondii patched family protein 0.0024 0.0037 0.1719
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0023 0.0035
Loa Loa (eye worm) hypothetical protein 0.0072 0.0155 0.0242
Schistosoma mansoni hypothetical protein 0.0096 0.0213 0.0391
Brugia malayi nuclear receptor NHR-88 0.0021 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Toxoplasma gondii hypothetical protein 0.0024 0.0037 0.1719
Onchocerca volvulus 0.0024 0.0037 0.0063
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0048 0.2141
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0097 0.0215 0.0336
Loa Loa (eye worm) hypothetical protein 0.0024 0.0037 0.0056
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0023 0.0021

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.144 uM/ml Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs ChEMBL. 18986199
MIC (functional) = 235 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv after 2 weeks by agar dilution method ChEMBL. 18471021

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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