Detailed information for compound 984776

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 445.358 | Formula: C23H18Cl2O3S
  • H donors: 1 H acceptors: 2 LogP: 6.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1O)/C=C(\C(=O)c1ccc(cc1)Cl)/SCc1ccc(cc1)Cl
  • InChi: 1S/C23H18Cl2O3S/c1-28-21-11-4-16(12-20(21)26)13-22(23(27)17-5-9-19(25)10-6-17)29-14-15-2-7-18(24)8-3-15/h2-13,26H,14H2,1H3/b22-13+
  • InChiKey: FOQHXJPUIMAQMQ-LPYMAVHISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Tubulin alpha 1 chain 0.0122 0.0413 0.0425
Schistosoma mansoni tubulin subunit beta 0.0066 0.0186 0.0702
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0037 0.0138
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.00000033598 0.0000081328
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0036 0.0866
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0542
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0046 0.0048
Entamoeba histolytica tubulin family protein 0.0066 0.0186 0.2603
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0038
Loa Loa (eye worm) alpha-tubulin 0.0122 0.0413 0.3555
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0015 0.0364
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0049 0.0068
Schistosoma mansoni ABC transporter 0.0025 0.002 0.0077
Toxoplasma gondii alpha-tubulin I, putative 0.0122 0.0413 0.1545
Brugia malayi alpha-tubulin 0.0122 0.0413 0.057
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0185
Echinococcus multilocularis tubulin alpha 1C chain 0.0122 0.0413 0.0425
Onchocerca volvulus 0.028 0.105 0.105
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0046 0.0175
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0031 0.0046 0.0191
Loa Loa (eye worm) tubulin beta-1 chain 0.0066 0.0186 0.1598
Brugia malayi RNA, U transporter 1 0.0082 0.0251 0.0347
Brugia malayi Muscleblind-like protein 0.0146 0.0511 0.0705
Brugia malayi intermediate filament protein 0.0026 0.0027 0.0038
Echinococcus granulosus tar DNA binding protein 0.0127 0.0433 0.1634
Schistosoma mansoni transient receptor potential channel 0.0064 0.018 0.0679
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0038 0.0082
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0186 0.1598
Onchocerca volvulus 0.028 0.105 0.105
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.1747 0.1797
Echinococcus multilocularis muscleblind protein 0.0146 0.0511 0.0525
Loa Loa (eye worm) hypothetical protein 0.0036 0.0066 0.0571
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1178 0.4673 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0063 0.0105
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Trypanosoma cruzi zeta tubulin, putative 0.0029 0.0036 0.0134
Schistosoma mansoni hypothetical protein 0.0081 0.0249 0.094
Trichomonas vaginalis tubulin beta chain, putative 0.0122 0.0413 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0122 0.0413 0.0425
Trypanosoma cruzi zeta tubulin, putative 0.0029 0.0036 0.0134
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.0261 0.0986
Leishmania major hypothetical protein, conserved 0.0025 0.0022 0.006
Schistosoma mansoni tubulin subunit beta 0.0066 0.0186 0.0702
Giardia lamblia ABC transporter 0.0028 0.0035 0.0132
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0063 0.1524
Schistosoma mansoni ran 0.0021 0.0006 0.0024
Schistosoma mansoni tubulin subunit beta 0.0066 0.0186 0.0702
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0018 0.0038
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0046 0.1122
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0015 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0261 0.6316
Echinococcus multilocularis tubulin alpha chain 0.0122 0.0413 0.0425
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0155
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0185
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.2197
Trypanosoma brucei tubulin delta chain 0.0029 0.0036 0.0134
Echinococcus granulosus tubulin epsilon chain 0.0066 0.0186 0.0702
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0029 0.0038 0.0119
Echinococcus granulosus lamin dm0 0.0026 0.0027 0.0103
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.0326 0.045
Echinococcus multilocularis tubulin alpha 1C chain 0.0122 0.0413 0.0425
Giardia lamblia Epsilon tubulin 0.0029 0.0036 0.0134
Loa Loa (eye worm) tubulin alpha chain 0.0122 0.0413 0.3555
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0046 0.1122
Trichomonas vaginalis abcb9, putative 0.0031 0.0046 0.1122
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0622 0.243 0.5199
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.0186 0.4496
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0029 0.0036 0.0134
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0193
Toxoplasma gondii beta tubulin 0.0066 0.0186 0.0695
Echinococcus multilocularis tubulin beta 1 chain 0.0066 0.0186 0.0191
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0063 0.0238
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0542
Echinococcus granulosus GPCR family 2 0.0032 0.0049 0.0185
Schistosoma mansoni multidrug resistance protein 0.0031 0.0046 0.0175
Echinococcus multilocularis tar DNA binding protein 0.0127 0.0433 0.0445
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Trypanosoma cruzi tubulin delta chain 0.0029 0.0036 0.0134
Brugia malayi beta-lactamase 0.0035 0.0063 0.0087
Toxoplasma gondii kinesin motor domain-containing protein 0.0026 0.0025 0.0093
Trypanosoma brucei ATP-binding cassette protein, putative 0.0029 0.0038 0.0143
Trichomonas vaginalis tubulin, putative 0.0037 0.0071 0.1711
Schistosoma mansoni hypothetical protein 0.0069 0.0198 0.0747
Echinococcus multilocularis tubulin delta chain 0.0029 0.0036 0.0037
Trypanosoma brucei epsilon tubulin 0.0066 0.0186 0.0695
Echinococcus multilocularis protoporphyrinogen oxidase 0.0083 0.0255 0.0263
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0029 0.0038 0.0119
Schistosoma mansoni tubulin subunit beta 0.0066 0.0186 0.0702
Schistosoma mansoni hypothetical protein 0.0024 0.0018 0.0067
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0049 0.0068
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0031 0.0046 0.0173
Trypanosoma brucei beta tubulin 0.0066 0.0186 0.0695
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0318
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0038 0.0082
Trypanosoma cruzi beta tubulin, putative 0.0066 0.0186 0.0695
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.2197
Plasmodium falciparum tubulin beta chain 0.0066 0.0186 0.0695
Mycobacterium ulcerans beta-lactamase 0.0035 0.0063 0.0135
Echinococcus multilocularis replication factor c subunit 1 0.002 0.00000033598 0.00000034562
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.0084
Loa Loa (eye worm) hypothetical protein 0.0097 0.0312 0.2686
Entamoeba histolytica hypothetical protein 0.0037 0.0068 0.0957
Echinococcus multilocularis tubulin epsilon chain 0.0066 0.0186 0.0191
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.2197
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0255 0.0955
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0018 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0049 0.0185
Giardia lamblia Beta tubulin 0.0066 0.0186 0.0695
Trichomonas vaginalis tubulin alpha chain, putative 0.0037 0.0071 0.1711
Schistosoma mansoni hypothetical protein 0.0081 0.0249 0.094
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.0218
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.028 0.105 0.1449
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0083 0.0255 0.0547
Entamoeba histolytica Ran family GTPase 0.0021 0.0006 0.0088
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.003 0.0044 0.0165
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0015 0.0364
Entamoeba histolytica kinesin, putative 0.0026 0.0025 0.0348
Echinococcus granulosus alpha tubulin 0.0122 0.0413 0.1561
Trypanosoma brucei ABC transporter, putative 0.0029 0.0038 0.0143
Leishmania major gamma-tubulin 0.0066 0.0186 0.0673
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0186 0.0191
Echinococcus multilocularis peroxisome assembly protein 26 0.0122 0.0413 0.0425
Onchocerca volvulus 0.0026 0.0027 0.0027
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0063 0.0105
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0066 0.0068
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Trichomonas vaginalis tubulin, putative 0.0029 0.0036 0.0866
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0006 0.0024
Echinococcus granulosus epidermal growth factor receptor 0.0299 0.1125 0.425
Toxoplasma gondii ABC1 family protein 0.0035 0.0063 0.0236
Schistosoma mansoni tubulin subunit beta 0.0029 0.0036 0.0135
Brugia malayi Tubulin beta chain 0.0029 0.0036 0.0049
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0046 0.0175
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Echinococcus granulosus expressed conserved protein 0.0185 0.0665 0.2514
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0037 0.0138
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0038
Trypanosoma brucei epsilon tubulin 0.0066 0.0186 0.0695
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Plasmodium vivax tubulin epsilon chain, putative 0.0066 0.0186 0.0695
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0038 0.0082
Onchocerca volvulus 0.0037 0.0071 0.0071
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0046 0.065
Echinococcus granulosus Tubulin alpha 1 chain 0.0122 0.0413 0.1561
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0006 0.0024
Trypanosoma cruzi tubulin gamma chain 0.0066 0.0186 0.0695
Loa Loa (eye worm) hypothetical protein 0.0094 0.0298 0.2565
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0186 0.0191
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0622 0.243 1
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Brugia malayi Tubulin alpha-2 chain 0.0122 0.0413 0.057
Plasmodium falciparum tubulin delta chain, putative 0.0029 0.0036 0.0134
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0038 0.0144
Loa Loa (eye worm) ShTK domain-containing protein 0.028 0.105 0.9033
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0255 0.0955
Trichomonas vaginalis tubulin beta chain, putative 0.0122 0.0413 1
Plasmodium vivax hypothetical protein, conserved 0.0083 0.0255 0.0955
Schistosoma mansoni tyrosine kinase 0.0159 0.0561 0.2119
Plasmodium falciparum telomerase reverse transcriptase 0.0683 0.2674 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0063 0.0542
Brugia malayi beta-lactamase family protein 0.0035 0.0063 0.0087
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.0261 0.0268
Giardia lamblia Alpha-tubulin 0.0122 0.0413 0.1545
Echinococcus granulosus Tubulin alpha 1 chain 0.0122 0.0413 0.1561
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0024
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0063 0.1524
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0186 0.4496
Mycobacterium ulcerans lipase LipD 0.0035 0.0063 0.0135
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0054
Schistosoma mansoni amine oxidase 0.0083 0.0255 0.0965
Loa Loa (eye worm) hypothetical protein 0.01 0.0326 0.2805
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0063 0.1524
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Trichomonas vaginalis taga, putative 0.0031 0.0046 0.1122
Echinococcus granulosus beta tubulin 0.0066 0.0186 0.0702
Entamoeba histolytica hypothetical protein 0.0037 0.0068 0.0957
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0046 0.0048
Entamoeba histolytica P-glycoprotein-2, putative 0.0031 0.0046 0.065
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Echinococcus multilocularis tubulin gamma 1 chain 0.0066 0.0186 0.0191
Echinococcus multilocularis tubulin alpha chain 0.0122 0.0413 0.0425
Trichomonas vaginalis tubulin beta chain, putative 0.0122 0.0413 1
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0049 0.0421
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.1747 0.6602
Loa Loa (eye worm) tubulin alpha-3 chain 0.0085 0.0263 0.2264
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.0252
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0027 0.0234
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0622 0.243 0.9087
Leishmania major delta tubulin, putative 0.0029 0.0036 0.0111
Trichomonas vaginalis tubulin beta chain, putative 0.0122 0.0413 1
Onchocerca volvulus 0.0031 0.0046 0.0046
Giardia lamblia Alpha-tubulin 0.0122 0.0413 0.1545
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0022 0.0084
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.0703
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0029 0.0036 0.0147
Trichomonas vaginalis tubulin epsilon chain, putative 0.0122 0.0413 1
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0083 0.0255 1
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0185
Loa Loa (eye worm) tubulin alpha 2 0.0056 0.0148 0.1274
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0022 0.0084
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0083 0.0255 0.0955
Toxoplasma gondii ATPase, AAA family protein 0.002 0.00000033598 0.0000012566
Echinococcus granulosus tubulin alpha chain 0.0122 0.0413 0.1561
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Loa Loa (eye worm) tubulin gamma chain 0.0066 0.0186 0.1598
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0036 0.0866
Brugia malayi Telomerase reverse transcriptase 0.1816 0.7247 1
Toxoplasma gondii beta-tubulin, putative 0.0066 0.0186 0.0695
Schistosoma mansoni multidrug resistance protein 0.0031 0.0046 0.0175
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.243 0.9721 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0029 0.0036 0.0866
Loa Loa (eye worm) hypothetical protein 0.0085 0.0263 0.2264
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0025
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0542
Loa Loa (eye worm) ABC transporter 0.0025 0.002 0.0176
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0046 0.0048
Schistosoma mansoni lamin 0.0026 0.0027 0.0103
Schistosoma mansoni amine oxidase 0.0083 0.0255 0.0965
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0122 0.0413 1
Leishmania major importin beta-1 subunit, putative 0.0023 0.0015 0.0033
Entamoeba histolytica tubulin alpha chain, putative 0.0122 0.0413 0.579
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0068 0.0258
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0018 0.0252
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0094 0.0298 0.2565
Entamoeba histolytica hypothetical protein 0.0023 0.0015 0.021
Leishmania major epsilon tubulin, putative 0.0066 0.0186 0.0673
Echinococcus multilocularis 0.0083 0.0255 0.0263
Brugia malayi Cell division protein ftsZ 0.0029 0.0036 0.0049
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0046 0.1122
Mycobacterium leprae Probable lipase LipE 0.0035 0.0063 0.2466
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0433 0.1634
Schistosoma mansoni tyrosine kinase 0.0299 0.1125 0.425
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.2647 0.2722
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0049 0.005
Trypanosoma brucei alpha tubulin 0.0122 0.0413 0.1545
Echinococcus granulosus muscleblind protein 0.0146 0.0511 0.193
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0029 0.0038 0.0143
Brugia malayi amine oxidase, flavin-containing family protein 0.0083 0.0255 0.0352
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0085 0.0263 0.637
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0022 0.0084
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.0261 0.2245
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0006 0.0024
Echinococcus multilocularis Niemann Pick C1 protein 0.0281 0.1054 0.1084
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.2197
Loa Loa (eye worm) alpha-tubulin 0.0122 0.0413 0.3555
Schistosoma mansoni tyrosinase precursor 0.028 0.105 0.3967
Schistosoma mansoni tubulin subunit alpha 0.0029 0.0036 0.0135
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0656 0.2479
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0018 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0433 0.1634
Echinococcus granulosus replication factor c subunit 1 0.002 0.00000033598 0.0000012695
Brugia malayi RNA binding protein 0.0127 0.0433 0.0597
Echinococcus granulosus Niemann Pick C1 protein 0.0197 0.0714 0.2696
Trypanosoma cruzi ABC transporter, putative 0.0029 0.0038 0.0143
Schistosoma mansoni tubulin subunit alpha 0.0122 0.0413 0.1561
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.018 0.0679
Loa Loa (eye worm) hypothetical protein 0.0033 0.0053 0.0458
Brugia malayi multidrug resistance protein 3 0.0031 0.0046 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0656 0.0675
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0186 0.0191
Plasmodium vivax tubulin beta chain, putative 0.0066 0.0186 0.0695
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0247 0.3455
Trypanosoma brucei beta tubulin 0.0066 0.0186 0.0695
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0299 0.0308
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.2197
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Echinococcus multilocularis multidrug resistance protein 1 0.0031 0.0046 0.0048
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.0186 0.4496
Brugia malayi Tubulin alpha chain 0.0029 0.0036 0.0049
Schistosoma mansoni kinesin eg-5 0.0026 0.0025 0.0094
Trypanosoma cruzi epsilon tubulin, putative 0.0066 0.0186 0.0695
Schistosoma mansoni hypothetical protein 0.0173 0.0618 0.2335
Trypanosoma brucei telomerase reverse transcriptase 0.0683 0.2674 1
Trypanosoma brucei beta tubulin 0.0066 0.0186 0.0695
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0186 0.0191
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0037 0.0138
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0063 0.0065
Trypanosoma brucei zeta tubulin 0.0029 0.0036 0.0134
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0186 0.0702
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0038 0.0144
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0046 0.1122
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0068 0.0258
Echinococcus granulosus snurportin 1 0.0308 0.1162 0.4391
Trichomonas vaginalis tubulin beta chain, putative 0.0122 0.0413 1
Plasmodium vivax kinesin-5 0.0026 0.0025 0.0093
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.028 0.105 0.1449
Brugia malayi beta-tubulin, identical 0.0066 0.0186 0.0256
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0063 0.0105
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0044
Onchocerca volvulus 0.0083 0.0255 0.0255
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0024
Loa Loa (eye worm) hypothetical protein 0.0061 0.0167 0.1433
Brugia malayi Importin beta-1 subunit 0.0029 0.0037 0.0051
Brugia malayi Niemann-Pick C1 protein precursor 0.0197 0.0714 0.0985
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0031 0.0046 0.0399
Plasmodium falciparum protoporphyrinogen oxidase 0.0083 0.0255 0.0955
Brugia malayi Tubulin gamma chain 0.0066 0.0186 0.0256
Mycobacterium ulcerans oxidoreductase 0.0083 0.0255 0.0547
Brugia malayi tubulin alpha-2 chain 0.0122 0.0413 0.057
Loa Loa (eye worm) beta-tubulin 0.0066 0.0186 0.1598
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Trichomonas vaginalis ran, putative 0.0021 0.0006 0.0153
Echinococcus granulosus Protein patched homolog 1 0.0084 0.0261 0.0986
Echinococcus multilocularis tubulin alpha chain 0.0122 0.0413 0.0425
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0255 0.0965
Treponema pallidum cell division protein FtsZ 0.0029 0.0036 1
Schistosoma mansoni tubulin subunit beta 0.0066 0.0186 0.0702
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0186 0.0191
Echinococcus multilocularis tubulin subunit beta 0.0066 0.0186 0.0191
Trypanosoma cruzi alpha tubulin, putative 0.0122 0.0413 0.1545
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0029 0.0036 0.0866
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0046 0.1122
Brugia malayi hypothetical protein 0.0037 0.0068 0.0094
Giardia lamblia Telomerase catalytic subunit 0.0683 0.2674 1
Mycobacterium tuberculosis Cell division protein FtsZ 0.0029 0.0036 0.0042
Echinococcus multilocularis lamin 0.0026 0.0027 0.0028
Plasmodium vivax telomerase reverse transcriptase, putative 0.0683 0.2674 1
Brugia malayi CHE-14 protein 0.0084 0.0261 0.036
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0022 0.0084
Loa Loa (eye worm) hypothetical protein 0.0197 0.0714 0.614
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Echinococcus granulosus tubulin alpha chain 0.0122 0.0413 0.1561
Echinococcus multilocularis lamin dm0 0.0026 0.0027 0.0028
Echinococcus granulosus tubulin gamma 1 chain 0.0066 0.0186 0.0702
Plasmodium vivax tubulin alpha chain, putative 0.0122 0.0413 0.1545
Entamoeba histolytica tubulin gamma chain 0.0066 0.0186 0.2603
Giardia lamblia Delta tubulin 0.0029 0.0036 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0049 0.0185
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0038 0.0039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0083 0.0255 0.055
Plasmodium falciparum tubulin epsilon chain, putative 0.0066 0.0186 0.0695
Loa Loa (eye worm) hypothetical protein 0.0083 0.0255 0.2197
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0031 0.0046 0.1122
Echinococcus multilocularis epidermal growth factor receptor 0.0299 0.1125 0.1157
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0031 0.0046 0.0173
Schistosoma mansoni alpha tubulin 0.0122 0.0413 0.1561
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0046 0.0048
Trypanosoma cruzi UDP-galactopyranose mutase 0.0083 0.0255 0.0955
Giardia lamblia Gamma tubulin 0.0066 0.0186 0.0695
Brugia malayi Tubulin alpha chain 0.0122 0.0413 0.057
Loa Loa (eye worm) hypothetical protein 0.0032 0.0049 0.0421
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0155
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0022 0.0009 0.0214
Entamoeba histolytica tubulin family protein 0.0066 0.0186 0.2603
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Leishmania major hypothetical protein, conserved 0.0035 0.0063 0.0212
Schistosoma mansoni tyrosine kinase 0.0095 0.0305 0.1154
Trypanosoma cruzi epsilon tubulin, putative 0.0066 0.0186 0.0695
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0247 0.3455
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.0433 0.3722
Echinococcus granulosus tubulin alpha 3 chain 0.0122 0.0413 0.1561
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0186 0.0702
Echinococcus multilocularis Tubulin alpha 1 chain 0.0122 0.0413 0.0425
Mycobacterium tuberculosis Possible oxidoreductase 0.0083 0.0255 0.055
Echinococcus multilocularis beta tubulin 0.0066 0.0186 0.0191
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0063 0.0135
Plasmodium falciparum multidrug resistance protein 1 0.0031 0.0046 0.0173
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0622 0.243 1
Trypanosoma brucei alpha tubulin 0.0122 0.0413 0.1545
Mycobacterium ulcerans monoamine oxidase 0.0083 0.0255 0.0547
Echinococcus multilocularis tubulin alpha chain 0.0122 0.0413 0.0425
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0542
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0186 0.1598
Loa Loa (eye worm) hypothetical protein 0.003 0.0044 0.0376
Loa Loa (eye worm) TK/EGFR protein kinase 0.0299 0.1125 0.9678
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0083 0.0255 0.0955
Echinococcus multilocularis hypothetical protein 0.0122 0.0413 0.0425
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0063 0.1524
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Mycobacterium ulcerans dehydrogenase 0.0083 0.0255 0.0547
Echinococcus granulosus epidermal growth factor receptor 0.016 0.0568 0.2145
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0063 0.0105
Plasmodium vivax ABC transporter G family member 2, putative 0.0029 0.0038 0.0143
Schistosoma mansoni intermediate filament proteins 0.0026 0.0027 0.0103
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0186 0.4496
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0046 0.0175
Trichomonas vaginalis tubulin, putative 0.0066 0.0186 0.4496
Mycobacterium ulcerans hypothetical protein 0.0024 0.0018 0.0038
Schistosoma mansoni tyrosine kinase 0.0159 0.0561 0.2119
Echinococcus multilocularis Niemann Pick C1 protein 0.0197 0.0714 0.0734
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0063 0.0236
Echinococcus multilocularis tubulin alpha chain 0.0122 0.0413 0.0425
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0186 0.0702
Onchocerca volvulus 0.0035 0.0063 0.0063
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0622 0.243 0.5199
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Brugia malayi Tubulin alpha-2 chain 0.0122 0.0413 0.057
Schistosoma mansoni hypothetical protein 0.0081 0.0249 0.094
Echinococcus granulosus Niemann Pick C1 protein 0.0281 0.1054 0.3982
Brugia malayi ABC transporter family protein 0.0025 0.002 0.0028
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0046 0.1122
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.1095 0.4338 1
Plasmodium falciparum importin beta, putative 0.0029 0.0037 0.0138
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0009 0.0033
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0044
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Entamoeba histolytica tubulin alpha-1 chain 0.0122 0.0413 0.579
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0083 0.0255 0.0955
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0066 0.0251
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0105
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0018 0.0252
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0095 0.0305 0.0314
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0622 0.243 0.5199
Loa Loa (eye worm) tubulin alpha chain 0.0122 0.0413 0.3555
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0299 0.113
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.2647 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0037 0.0071 0.1711
Giardia lamblia Kinesin-5 0.0026 0.0025 0.0093
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0542
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.083 0.1879
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0066 0.0186 0.0191
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0656 0.2479
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.00000033598 0.0000047088
Schistosoma mansoni hypothetical protein 0.0308 0.1162 0.4391
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0018 0.0703
Schistosoma mansoni tyrosine kinase 0.0159 0.0561 0.2119
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0063 0.0105
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0063 0.0135
Echinococcus multilocularis GPCR, family 2 0.0032 0.0049 0.005
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0038 0.0144
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0186 0.0702
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0046 0.0048
Echinococcus granulosus tubulin beta 4A class IVa 0.0066 0.0186 0.0702
Schistosoma mansoni tubulin subunit gamma 0.0066 0.0186 0.0702
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0083 0.0255 0.0955
Loa Loa (eye worm) tyrosinase 1 0.028 0.105 0.9033
Plasmodium falciparum alpha tubulin 2 0.0122 0.0413 0.1545
Schistosoma mansoni lamin 0.0026 0.0027 0.0103
Echinococcus multilocularis 0.0092 0.0293 0.0302
Loa Loa (eye worm) tubulin alpha-2 chain 0.0122 0.0413 0.3555
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0025
Mycobacterium leprae cell division protein FtsZ 0.0029 0.0036 0.1401
Echinococcus granulosus multidrug resistance protein 1 0.0022 0.0009 0.0033
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.018 0.0185
Echinococcus multilocularis tubulin alpha 3 chain 0.0122 0.0413 0.0425
Schistosoma mansoni alpha tubulin 0.0122 0.0413 0.1561
Schistosoma mansoni transient receptor potential channel 4 0.0097 0.0312 0.118
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0083 0.0255 0.0263
Loa Loa (eye worm) kinesin-like protein KLP2 0.0026 0.0025 0.0214
Trichomonas vaginalis tubulin beta chain, putative 0.0037 0.0071 0.1711
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.1162 1
Schistosoma mansoni alpha tubulin 0.0122 0.0413 0.1561
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.1747 0.1797
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.0024
Echinococcus multilocularis protein dispatched 1 0.0096 0.0309 0.0318
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0063 0.0105
Echinococcus granulosus multidrug resistance protein 1 0.0031 0.0046 0.0175
Schistosoma mansoni tubulin subunit delta 0.0029 0.0036 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.0326 0.045
Entamoeba histolytica P-glycoprotein-1 0.0031 0.0046 0.065
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.0326 0.2805
Loa Loa (eye worm) hypothetical protein 0.0035 0.0063 0.0542
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0247 0.3455
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0046 0.1122
Giardia lamblia Beta tubulin 0.0066 0.0186 0.0695
Loa Loa (eye worm) hypothetical protein 0.0026 0.0027 0.0234
Trichomonas vaginalis tubulin epsilon chain, putative 0.0122 0.0413 1
Brugia malayi Common central domain of tyrosinase family protein 0.028 0.105 0.1449
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.0186 0.4496
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.0433 0.0597
Echinococcus granulosus tubulin subunit beta 0.0066 0.0186 0.0702
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0186 0.0702
Schistosoma mansoni transient receptor potential channel 0.0097 0.0312 0.118
Onchocerca volvulus 0.0024 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0037 0.0068 0.0957
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0656 0.0905
Entamoeba histolytica hypothetical protein 0.0037 0.0068 0.0957
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0433 0.1634
Trichomonas vaginalis tubulin alpha chain, putative 0.0037 0.0071 0.1711
Onchocerca volvulus 0.0026 0.0027 0.0027
Plasmodium vivax tubulin gamma chain, putative 0.0066 0.0186 0.0695
Leishmania major p-glycoprotein 0.0031 0.0046 0.015
Trypanosoma brucei tubulin gamma chain 0.0066 0.0186 0.0695
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.1178 0.4673 1
Echinococcus multilocularis musashi 0.0026 0.0027 0.0028
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Leishmania major UDP-galactopyranose mutase 0.0083 0.0255 0.0934
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.0186 0.4496
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0031 0.0046 0.1122
Schistosoma mansoni tyrosine kinase 0.0095 0.0305 0.1154
Trichomonas vaginalis tubulin alpha chain, putative 0.0037 0.0071 0.1711
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Echinococcus multilocularis epidermal growth factor receptor 0.016 0.0568 0.0584
Echinococcus granulosus tubulin subunit TubB 0.0122 0.0413 0.1561
Brugia malayi hypothetical protein 0.0025 0.0022 0.0031
Schistosoma mansoni ran 0.0021 0.0006 0.0024
Plasmodium vivax delta tubulin, putative 0.0029 0.0036 0.0134
Toxoplasma gondii beta-1 tubulin, putative 0.0066 0.0186 0.0695
Onchocerca volvulus 0.0035 0.0063 0.0063
Brugia malayi SWIRM domain containing protein 0.0083 0.0255 0.0352
Trypanosoma brucei beta tubulin 0.0066 0.0186 0.0695
Trichomonas vaginalis tubulin beta chain, putative 0.0122 0.0413 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0155
Loa Loa (eye worm) tubulin beta chain 0.0066 0.0186 0.1598
Echinococcus multilocularis short transient receptor potential channel 6 0.0064 0.018 0.0185
Trypanosoma brucei alpha tubulin, putative 0.0037 0.0071 0.0264
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.028 0.105 0.1449
Plasmodium falciparum ABC transporter G family member 2 0.0029 0.0038 0.0143
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0006 0.0006
Echinococcus granulosus neuropeptide s receptor 0.0453 0.1747 0.6602
Brugia malayi Tubulin beta-1 chain 0.0066 0.0186 0.0256
Brugia malayi Tubulin beta chain 0.0037 0.0071 0.0098
Echinococcus granulosus geminin 0.0166 0.059 0.223
Echinococcus granulosus tubulin alpha 3 chain 0.0122 0.0413 0.1561
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Toxoplasma gondii RNA-directed DNA polymerase 0.0683 0.2674 1
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0046 0.0175
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0063 0.0236
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0031 0.0046 0.0048
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0063 0.1524
Brugia malayi tubulin alpha chain - mouse 0.0122 0.0413 0.057
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0049 0.005
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0027 0.0234
Echinococcus granulosus Tubulin alpha 1 chain 0.0122 0.0413 0.1561
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0198 0.0273
Brugia malayi Protein kinase domain containing protein 0.0095 0.0305 0.0422
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.0186 0.4496
Schistosoma mansoni tubulin subunit beta 0.0066 0.0186 0.0702
Schistosoma mansoni smdr2 0.0031 0.0046 0.0175
Trichomonas vaginalis abcb9, putative 0.0031 0.0046 0.1122
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0063 0.0087
Onchocerca volvulus 0.028 0.105 0.105
Schistosoma mansoni hypothetical protein 0.0166 0.059 0.223
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0029 0.0038 0.0143
Loa Loa (eye worm) hypothetical protein 0.0103 0.0337 0.2904
Echinococcus granulosus tubulin alpha chain 0.0122 0.0413 0.1561
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0063 0.0542
Schistosoma mansoni hypothetical protein 0.0037 0.0068 0.0258
Loa Loa (eye worm) hypothetical protein 0.0122 0.0413 0.3555
Schistosoma mansoni hypothetical protein 0.0032 0.0049 0.0185
Trypanosoma brucei epsilon tubulin 0.0066 0.0186 0.0695
Schistosoma mansoni hypothetical protein 0.0081 0.0249 0.094
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0068 0.007
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0037 0.0038
Loa Loa (eye worm) hypothetical protein 0.0069 0.0198 0.1701
Toxoplasma gondii alpha tubulin TUBA1 0.0122 0.0413 0.1545
Schistosoma mansoni tubulin subunit alpha 0.0122 0.0413 0.1561
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0031 0.0046 0.015
Brugia malayi beta-lactamase family protein 0.0035 0.0063 0.0087
Schistosoma mansoni importin beta-1 0.0029 0.0037 0.014
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Entamoeba histolytica ABC transporter, putative 0.0029 0.0038 0.0534
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0656 0.0675
Echinococcus granulosus tubulin delta chain 0.0029 0.0036 0.0135
Plasmodium vivax importin-beta 2, putative 0.0029 0.0037 0.0138
Schistosoma mansoni tyrosine kinase 0.016 0.0568 0.2145
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0022 0.0084
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0105
Echinococcus granulosus tubulin beta 1 chain 0.0066 0.0186 0.0702
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0399
Echinococcus multilocularis tubulin subunit TubB 0.0122 0.0413 0.0425
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.00000033598 0.0000012695
Onchocerca volvulus 0.028 0.105 0.105
Echinococcus granulosus tubulin alpha 1C chain 0.0122 0.0413 0.1561
Echinococcus granulosus short transient receptor potential channel 6 0.0064 0.018 0.0679
Echinococcus multilocularis transient receptor potential gamma protein 0.0097 0.0312 0.0321
Mycobacterium ulcerans hypothetical protein 0.0035 0.0063 0.0135
Echinococcus multilocularis expressed conserved protein 0.0185 0.0665 0.0685
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0018 0.0044
Leishmania major zeta tubulin, putative 0.0029 0.0036 0.0111
Schistosoma mansoni tyrosinase precursor 0.028 0.105 0.3967
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0046 0.0175
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0006 0.0024
Echinococcus multilocularis tubulin alpha 3 chain 0.0122 0.0413 0.0425
Schistosoma mansoni multidrug resistance protein 0.0031 0.0046 0.0175
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Trypanosoma brucei beta tubulin 0.0066 0.0186 0.0695
Trichomonas vaginalis tubulin gamma chain, putative 0.0029 0.0036 0.0866
Mycobacterium tuberculosis Conserved protein 0.0035 0.0063 0.0105
Loa Loa (eye worm) hypothetical protein 0.0146 0.0511 0.4395
Echinococcus granulosus transient receptor potential gamma protein 0.0097 0.0312 0.118
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.028 0.105 0.1449
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0029 0.0038 0.0144
Brugia malayi ShTK domain containing protein 0.028 0.105 0.1449
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.00000033598 0.0000081328
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0015 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0018 0.0025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0656 0.5645
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0247 0.3455
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0095 0.0305 0.1154
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Loa Loa (eye worm) tubulin alpha 2 0.0094 0.0298 0.2565
Loa Loa (eye worm) tubulin beta-4 chain 0.0066 0.0186 0.1598
Echinococcus granulosus tubulin alpha chain 0.0122 0.0413 0.1561
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0038 0.0039
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0066 0.0091
Echinococcus multilocularis geminin 0.0166 0.059 0.0607
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0083 0.0255 0.0955
Schistosoma mansoni tubulin subunit epsilon 0.0066 0.0186 0.0702
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0083 0.0255 0.0965
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0433 0.1634
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0083 0.0255 0.0965
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.0084
Entamoeba histolytica P-glycoprotein-2 0.0031 0.0046 0.065
Loa Loa (eye worm) tubulin beta-2A chain 0.0066 0.0186 0.1598
Echinococcus multilocularis snurportin 1 0.0308 0.1162 0.1196
Plasmodium falciparum alpha tubulin 1 0.0122 0.0413 0.1545
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0063 0.0236
Trichomonas vaginalis esterase, putative 0.0035 0.0063 0.1524
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0063 0.2466
Schistosoma mansoni tar DNA-binding protein 0.0127 0.0433 0.1634
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0063 0.0236
Loa Loa (eye worm) hypothetical protein 0.028 0.105 0.9033
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0038 0.0039
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0186 0.4496
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0066 0.0186 0.0695
Loa Loa (eye worm) RNA binding protein 0.0127 0.0433 0.3722
Loa Loa (eye worm) tubulin alpha 2 0.0094 0.0298 0.2565
Mycobacterium ulcerans cell division protein FtsZ 0.0029 0.0036 0.0077
Trypanosoma cruzi tubulin delta chain 0.0029 0.0036 0.0134
Brugia malayi Kinesin motor domain containing protein 0.0026 0.0025 0.0034
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0031 0.0046 0.1122
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0046 0.1122
Echinococcus granulosus intermediate filament protein 0.0026 0.0027 0.0103
Trypanosoma brucei alpha tubulin 0.0122 0.0413 0.1545
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.00000033598 0.0000081328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0656 0.2479
Schistosoma mansoni hypothetical protein 0.0166 0.059 0.223
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Onchocerca volvulus 0.0035 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0084 0.0261 0.2245
Echinococcus granulosus insulin receptor 0.0095 0.0305 0.1154
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0622 0.243 0.9087
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0027 0.0038
Giardia lamblia Beta tubulin 0.0066 0.0186 0.0695
Echinococcus granulosus tubulin alpha 1C chain 0.0122 0.0413 0.1561
Toxoplasma gondii histone lysine-specific demethylase 0.0083 0.0255 0.0955
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0031 0.0046 0.1122
Plasmodium falciparum tubulin gamma chain 0.0066 0.0186 0.0695
Brugia malayi ABC transporter family protein 0.0031 0.0046 0.0064
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0031 0.0046 0.0175
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0683 0.2674 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.02 0.0726 0.2742
Echinococcus multilocularis ATP binding cassette sub family B 0.003 0.0044 0.0045
Entamoeba histolytica fatty acid elongase, putative 0.0081 0.0247 0.3455
Loa Loa (eye worm) TAR-binding protein 0.0127 0.0433 0.3722
Echinococcus granulosus peroxisome assembly protein 26 0.0122 0.0413 0.1561
Echinococcus granulosus beta tubulin 0.0066 0.0186 0.0702
Entamoeba histolytica P-glyco protein 6, putative 0.0031 0.0046 0.065
Trypanosoma brucei zeta tubulin, putative 0.0029 0.0036 0.0134
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Echinococcus granulosus importin subunit beta 1 0.0029 0.0037 0.014
Plasmodium vivax multidrug resistance protein 1, putative 0.0031 0.0046 0.0173
Plasmodium vivax tubulin alpha chain, putative 0.0122 0.0413 0.1545
Echinococcus granulosus kinesin family 1 0.0199 0.0722 0.2728
Entamoeba histolytica P-glycoprotein 5, putative 0.0031 0.0046 0.065
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0622 0.243 0.5582
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0029 0.0036 0.0134
Chlamydia trachomatis protoporphyrinogen oxidase 0.0083 0.0255 0.1051
Schistosoma mansoni patched 1 0.0084 0.0261 0.0986
Brugia malayi TAR-binding protein 0.0127 0.0433 0.0597
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0399
Echinococcus multilocularis insulin receptor 0.0095 0.0305 0.0314
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0063 0.0238
Loa Loa (eye worm) ShTK domain-containing protein 0.028 0.105 0.9033
Brugia malayi hypothetical protein 0.0083 0.0255 0.0352
Echinococcus multilocularis kinesin family 1 0.0199 0.0722 0.0743
Leishmania major alpha tubulin 0.0122 0.0413 0.1525
Loa Loa (eye worm) hypothetical protein 0.0146 0.0511 0.4395
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.016 0.0568 0.2145
Trichomonas vaginalis tubulin, putative 0.0037 0.0071 0.1711
Trichomonas vaginalis ABC transporter, putative 0.0031 0.0046 0.1122
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0063 0.0105
Leishmania major telomerase reverse transcriptase, putative 0.0683 0.2674 1
Echinococcus multilocularis tubulin alpha 0.0066 0.0186 0.0191
Brugia malayi Furin-like cysteine rich region family protein 0.0299 0.1125 0.1552
Loa Loa (eye worm) TK/INSR protein kinase 0.0095 0.0305 0.2628
Schistosoma mansoni tubulin subunit alpha 0.0122 0.0413 0.1561
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0197 0.0714 1
Leishmania major beta tubulin 0.0066 0.0186 0.0673
Echinococcus granulosus microtubule associated protein 2 0.0676 0.2647 1
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0031 0.0046 0.0066
Trypanosoma brucei alpha tubulin 0.0122 0.0413 0.1545
Entamoeba histolytica P-glycoprotein-5 0.0031 0.0046 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0656 0.2479
Loa Loa (eye worm) tubulin beta chain 0.0029 0.0036 0.0308
Loa Loa (eye worm) multidrug resistance protein 3 0.0031 0.0046 0.0399
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0006 0.0009
Echinococcus granulosus tubulin alpha chain 0.0122 0.0413 0.1561
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0018 0.0038
Schistosoma mansoni transient receptor potential channel 0.0064 0.018 0.0679
Echinococcus multilocularis multidrug resistance protein 1 0.0022 0.0009 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0063 0.0238
Echinococcus granulosus lysine specific histone demethylase 1A 0.0083 0.0255 0.0965
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0018 0.0038
Echinococcus multilocularis beta tubulin 0.0066 0.0186 0.0191
Echinococcus granulosus tubulin alpha 0.0066 0.0186 0.0702
Echinococcus granulosus lamin 0.0026 0.0027 0.0103
Echinococcus multilocularis protein patched 0.0084 0.0261 0.0268
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0656 0.2479
Schistosoma mansoni tyrosine kinase 0.016 0.0568 0.2145
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0094 0.0298 0.7215
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0683 0.2674 1
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0511 0.0525
Plasmodium falciparum kinesin-5 0.0026 0.0025 0.0093
Loa Loa (eye worm) hypothetical protein 0.028 0.105 0.9033
Trichomonas vaginalis abcb9, putative 0.0031 0.0046 0.1122

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 1 uM Growth inhibition of human K562 cells expressing p210Bcr/Abl after 96 hrs by trypan blue exclusion assay ChEMBL. 20188579

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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