Detailed view for LOAG_09152

Basic information

TDR Targets ID: 939660
Loa Loa (eye worm), glycosyl hydrolase family 20
Source Database / ID:  KEGG  

pI: 4.9599 | Length (AA): 503 | MW (Da): 58299 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00728   Glycosyl hydrolase family 20, catalytic domain
PF14845   beta-acetyl hexosaminidase like

Gene Ontology

Mouse over links to read term descriptions.
GO:0004553   hydrolase activity, hydrolyzing O-glycosyl compounds  
GO:0004563   beta-N-acetylhexosaminidase activity  
GO:0005975   carbohydrate metabolic process  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
30 492 1now (A) 55 552 45.00 0 1 1.36638 -0.52
31 497 2gjx (A) 23 528 33.00 0 1 1.22273 -0.07
171 370 1yht (A) 20 229 30.00 0 1 0.753514 -0.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127470)

Species Accession Gene Product
Arabidopsis thaliana AT1G05590   beta-hexosaminidase 2
Arabidopsis thaliana AT1G65590   beta-hexosaminidase 3
Arabidopsis thaliana AT3G55260   beta-hexosaminidase 1
Brugia malayi Bm1_15330   Glycosyl hydrolase family 20, catalytic domain containing protein
Candida albicans CaO19.6673   beta-N-acetylglucosaminidase whose expression is induced when cells are grown in presence of GlcNAc
Caenorhabditis elegans CELE_T14F9.3   Protein HEX-1
Dictyostelium discoideum DDB_G0287033   glycoside hydrolase family 20 protein
Dictyostelium discoideum DDB_G0287597   glycoside hydrolase family 20 protein
Dictyostelium discoideum DDB_G0282539   glycoside hydrolase family 20 protein
Dictyostelium discoideum DDB_G0287659   glycoside hydrolase family 20 protein
Drosophila melanogaster Dmel_CG1318   Hexosaminidase 1
Echinococcus granulosus EgrG_000901900   beta hexosaminidase subunit alpha
Echinococcus granulosus EgrG_000582300   beta hexosaminidase subunit beta
Entamoeba histolytica EHI_007330   beta-N-acetylhexosaminidase, beta subunit
Entamoeba histolytica EHI_148130   beta-N-acetylhexosaminidase, alpha subunit
Entamoeba histolytica EHI_012010   beta-N-acetylhexosaminidase, putative
Entamoeba histolytica EHI_110500   beta-N-acetylhexosaminidase, putative
Echinococcus multilocularis EmuJ_000901900   beta hexosaminidase subunit alpha
Echinococcus multilocularis EmuJ_000582300   beta hexosaminidase subunit beta
Homo sapiens ENSG00000049860   hexosaminidase B (beta polypeptide)
Homo sapiens 3073   hexosaminidase A (alpha polypeptide)
Loa Loa (eye worm) LOAG_09152   glycosyl hydrolase family 20
Mus musculus ENSMUSG00000025232   hexosaminidase A
Mus musculus ENSMUSG00000021665   hexosaminidase B
Oryza sativa 4338802   Os05g0415700
Oryza sativa 4332084   Os03g0219400
Oryza sativa 4337620   Os05g0115900
Oryza sativa 4343697   Os07g0575500
Oryza sativa 4324914   Os01g0891000
Schistosoma japonicum Sjp_0015430   Beta-hexosaminidase subunit A1 precursor, putative
Schistosoma japonicum Sjp_0301380   ko:K01207 beta-N-acetylhexosaminidase [EC3.2.1.52], putative
Schistosoma japonicum Sjp_0202630   Beta-hexosaminidase subunit beta precursor, putative
Schistosoma mansoni Smp_134300   beta-hexosaminidase B
Schistosoma mansoni Smp_053900   beta-hexosaminidase B
Schmidtea mediterranea mk4.000500.02  
Schmidtea mediterranea mk4.019275.00   Beta-hexosaminidase A
Schmidtea mediterranea mk4.000500.04  
Schmidtea mediterranea mk4.029693.00  
Schmidtea mediterranea mk4.021857.00   Beta-hexosaminidase
Schmidtea mediterranea mk4.021503.00   Beta-hexosaminidase
Schmidtea mediterranea mk4.033971.00  
Schmidtea mediterranea mk4.001457.00   Putative beta-hexosaminidase B
Schmidtea mediterranea mk4.000662.07  
Trichomonas vaginalis TVAG_302140   beta-hexosaminidase, putative
Trichomonas vaginalis TVAG_133440   beta-hexosaminidase, putative
Trichomonas vaginalis TVAG_010780   beta-hexosaminidase B, putative
Trichomonas vaginalis TVAG_484030   beta-hexosaminidase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens hexosaminidase A (alpha polypeptide) Compounds References
Homo sapiens hexosaminidase B (beta polypeptide) Compounds References
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) Putative beta-hexosaminidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0185 0.2776 0
0.0267 0.409 1
0.018 0.4049 0.6837
0.040322 0.750852 1
0.0178 0.2658 1
0.0945 0.3139 0.3617
0.0945 0.3139 0.3617
0.0269 0.5242 0.5634
0.0175 0.5132 1
0.0465 0.2513 0.4179
0.0108 0.3506 0
0.0459 0.3097 0.4809
0.0237219 0.283972 0
0.0108 0.26 0.9131
0.0108 1 0.5
0.0393 0.296 0.7364
0.036 1 1
0.0093 0.5293 0.5131
0.0216 1 1
0.0374 1 1
0.0177 0.4988 0.4988
0.0198 1 1
0.0178 0.4003 0
0.0743 0.2559 0.333
0.0356 0.4443 1
0.0743 0.2559 0.333
0.0356 0.3308 0.3308
0.0198 1 1
0.0747 0.3458 0.5086
0.0175 0.3842 0.3842
0.0185 0.4982 1
0.0087 1 1
0.0389 0.7853 1
0.0365 0.7565 1
0.0362 1 1
0.0356 0.3308 0.3308
0.018 0.836 0.8336
0.0365 0.7565 1
0.0216 1 0.5
0.0374 1 1
0.0175 0.5132 0.7267
0.0393 0.296 0.7364
0.0542 0.2527 0.2527
0.0362 0.31 1
0.0216 1 1
0.0175 0.3801 1
0.0108 1 0.5
0.0356 0.3308 0.3308
0.0473 0.2734 0.6225
0.0108 1 0.5
0.0969 0.2985 0.4222
0.0542 0.2962 0.3889
0.0173 0.541 0.541
0.0177 0.5512 1
0.0459 0.3097 0.4809
0.0459 0.3097 0.4809
0.0264 0.3216 1
0.0371 0.3178 0
0.018 0.4049 0.6837
0.0945 0.3139 0.3617
0.0393 0.296 0.7364
0.0173 0.458 0.458
0.0177 0.4988 0.4988
0.0356 0.3308 0.3308
0.0393 0.296 0.7364
0.0386 1 1
0.0386 1 1
0.0362 1 1
0.0542 0.2962 0.3889
0.0389 0.7853 1
0.0536 1 1
0.0185 0.2776 0
0.0273 0.2941 0.3689
0.0751 0.2757 0.2757
0.0356 1 1
0.0459 0.3097 0.4809
0.0356 0.3308 0.3308
0.0362 0.4064 1
0.0175 0.5468 1
0.0459 0.3097 0.4809
0.0743 0.2559 0.333

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LOAG_09152 (Loa Loa (eye worm)), glycosyl hydrolase family 20
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