pI: 8.0505 |
Length (AA): 515 |
MW (Da): 53449 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 510 | 5nth (A) | 13 | 538 | 28.00 | 0 | 1 | 1.23995 | -0.03 |
8 | 512 | 3jru (B) | 1 | 489 | 32.00 | 0 | 1 | 1.39198 | -0.49 |
14 | 512 | 3h8e (A) | 4 | 495 | 39.00 | 0 | 1 | 1.34763 | -0.27 |
194 | 511 | 5ntd (A) | 209 | 521 | 35.00 | 0 | 1 | 1.07688 | -0.77 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127293)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G30920 | leucine aminopeptidase 2 |
Arabidopsis thaliana | AT4G30910 | cytosol aminopeptidase family protein |
Arabidopsis thaliana | AT2G24200 | aminopeptidase family protein |
Babesia bovis | BBOV_II004450 | leucine aminopeptidase, putative |
Cryptosporidium hominis | Chro.50116 | leucine aminopeptidase |
Cryptosporidium parvum | cgd5_2600 | putative leucine aminopeptidase; of possible plant or bacterial origin |
Chlamydia trachomatis | CT_045 | cytosol aminopeptidase |
Dictyostelium discoideum | DDB_G0279793 | leucine aminopeptidase |
Drosophila melanogaster | Dmel_CG13340 | Sperm-Leucylaminopeptidase 7 |
Drosophila melanogaster | Dmel_CG4439 | Sperm-Leucylaminopeptidase 8 |
Drosophila melanogaster | Dmel_CG32351 | Sperm-Leucylaminopeptidase 2 |
Drosophila melanogaster | Dmel_CG6372 | Sperm-Leucylaminopeptidase 1 |
Drosophila melanogaster | Dmel_CG18369 | Sperm-Leucylaminopeptidase 5 |
Drosophila melanogaster | Dmel_CG32064 | Sperm-Leucylaminopeptidase 4 |
Drosophila melanogaster | Dmel_CG32063 | Sperm-Leucylaminopeptidase 3 |
Drosophila melanogaster | Dmel_CG4750 | CG4750 gene product from transcript CG4750-RC |
Escherichia coli | b4260 | multifunctional aminopeptidase A: a cyteinylglycinase, transcription regulator and site-specific recombination factor |
Echinococcus granulosus | EgrG_001133600 | leucine aminopeptidase protein |
Echinococcus multilocularis | EmuJ_001133600 | leucine aminopeptidase protein |
Homo sapiens | ENSG00000002549 | leucine aminopeptidase 3 |
Leishmania braziliensis | LbrM.23.1030 | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 |
Leishmania donovani | LdBPK_231120.1 | cytosolic leucyl aminopeptidase |
Leishmania infantum | LinJ.23.1120 | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 |
Leishmania major | LmjF.23.0950 | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 |
Leishmania mexicana | LmxM.23.0950 | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 |
Mycobacterium leprae | ML0864c | Probable cytosol aminopeptidase PepB |
Mus musculus | ENSMUSG00000039682 | leucine aminopeptidase 3 |
Mycobacterium tuberculosis | Rv2213 | Probable aminopeptidase PepB |
Mycobacterium ulcerans | MUL_3573 | leucyl aminopeptidase |
Neospora caninum | NCLIV_042660 | Probable cytosol aminopeptidase, related |
Oryza sativa | 4352123 | Os12g0434400 |
Oryza sativa | 4330998 | Os02g0794700 |
Plasmodium berghei | PBANKA_1309900 | M17 leucyl aminopeptidase, putative |
Plasmodium falciparum | PF3D7_1446200 | M17 leucyl aminopeptidase |
Plasmodium knowlesi | PKNH_1236000 | M17 leucyl aminopeptidase, putative |
Plasmodium vivax | PVX_118180 | M17 leucyl aminopeptidase, putative |
Plasmodium yoelii | PY01898 | putative leucine aminopeptidase |
Schmidtea mediterranea | mk4.044959.00 | |
Trypanosoma brucei gambiense | Tbg972.8.2770 | cytosolic leucyl aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17, putative |
Trypanosoma brucei | Tb927.8.3060 | metallo-peptidase, Clan MF, Family M17 |
Trypanosoma congolense | TcIL3000_8_3050 | metallo-peptidase, Clan MF, Family M17, putative |
Trypanosoma cruzi | TcCLB.509859.40 | metallo-peptidase, Clan MF, Family M17, putative |
Trypanosoma cruzi | TcCLB.510515.60 | cytosolic leucyl aminopeptidase, putative |
Toxoplasma gondii | TGME49_290670 | leucyl aminopeptidase LAP |
Theileria parva | TP04_0561 | leucine aminopeptidase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0630 | leucyl aminopeptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.3060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.3060 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.3060 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.3060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4260 | Escherichia coli | non-essential | goodall |
PBANKA_1309900 | Plasmodium berghei | Slow | plasmo |
TGME49_290670 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Bos taurus | Cytosol aminopeptidase | Compounds | References |
Homo sapiens | leucine aminopeptidase 3 | Compounds | References |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | Compounds | References |
Sus scrofa | Cytosol aminopeptidase | Compounds | References |
Plasmodium falciparum | M17 leucyl aminopeptidase | Compounds | References |