Detailed information for compound 1028908

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.974 | Formula: C23H33ClN2O
  • H donors: 1 H acceptors: 1 LogP: 5.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)c(CCCN1CCN(CC1)C1CCCCC1)ccc2.Cl
  • InChi: 1S/C23H32N2O.ClH/c26-22-12-11-20-7-4-6-19(23(20)18-22)8-5-13-24-14-16-25(17-15-24)21-9-2-1-3-10-21;/h4,6-7,11-12,18,21,26H,1-3,5,8-10,13-17H2;1H
  • InChiKey: OCLFVRYYRIHUNL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Starlite/ChEMBL References
Cavia porcellus Sigma-1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase   229 aa 213 aa 21.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0023
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0025 0.0047 0.008
Entamoeba histolytica hypothetical protein 0.0142 0.0542 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0172 0.0461
Loa Loa (eye worm) hypothetical protein 0.0205 0.0803 0.2266
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Giardia lamblia Phosphatidylinositol 4-kinase 0.0025 0.0047 0.0537
Plasmodium falciparum flap endonuclease 1 0.0027 0.0056 0.0948
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0025 0.0047 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Plasmodium vivax hypothetical protein, conserved 0.0181 0.0704 1
Leishmania major hypothetical protein, conserved 0.0672 0.2768 1
Loa Loa (eye worm) hypothetical protein 0.0181 0.0704 0.1987
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0001
Chlamydia trachomatis cytosol aminopeptidase 0.0102 0.0372 0.5
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0056 0.0101
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0123 0.0461 0.0461
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0047 0.0365
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0081 0.0284 0.1459
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0122 0.0378
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0025 0.0047 0.008
Schistosoma mansoni hypothetical protein 0.0025 0.0047 0.0076
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0047 0.0107
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0025 0.0047 0.0094
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0128 0.0399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Onchocerca volvulus 0.0974 0.4038 1
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0047 0.0365
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.009 0.0257
Trypanosoma cruzi hypothetical protein, conserved 0.0647 0.2664 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Schistosoma mansoni leucine aminopeptidase 0.002 0.0029 0.0032
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0025 0.0047 0.0094
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0029 0.0029
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0172 0.0223
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.011
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0025 0.0047 0.071
Leishmania major phosphatidylinositol kinase, putative 0.0025 0.0047 0.0091
Schistosoma mansoni cpg binding protein 0.0031 0.0073 0.0137
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0025 0.0047 0.0479
Echinococcus multilocularis leucine aminopeptidase protein 0.0102 0.0372 0.0372
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0025 0.0047 0.0139
Loa Loa (eye worm) hypothetical protein 0.0055 0.0172 0.0486
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0172 0.0172
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0129 0.0485 0.1685
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0023 0.011
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0047 0.0365
Schistosoma mansoni hypothetical protein 0.0417 0.1695 0.3977
Echinococcus multilocularis GPCR, family 2 0.0205 0.0803 0.0803
Schistosoma mansoni hypothetical protein 0.0142 0.0542 0.1246
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0023
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0056 0.0157
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0205 0.0803 0.0803
Loa Loa (eye worm) hypothetical protein 0.0227 0.0898 0.2536
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0047 0.008
Brugia malayi CXXC zinc finger family protein 0.0029 0.0066 0.016
Toxoplasma gondii FATC domain-containing protein 0.0073 0.0249 0.3321
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.002 0.0029 0.0037
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0047 0.0047
Mycobacterium tuberculosis Probable lipase LipE 0.0181 0.0704 0.1438
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0023 0.0018
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0181 0.0704 0.1965
Mycobacterium leprae conserved hypothetical protein 0.0181 0.0704 1
Entamoeba histolytica hypothetical protein 0.0025 0.0047 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0704 0.0912
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0022 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0002
Schistosoma mansoni cpg binding protein 0.0029 0.0066 0.012
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0025 0.0047 0.0076
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0102 0.0372 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0546 0.1909
Loa Loa (eye worm) phosphatidylinositol 3 0.0129 0.0485 0.1369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0223 0.0492
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0073 0.0249 0.0322
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0144 0.0408
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.009 0.0257
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0047 0.0133
Echinococcus multilocularis dna polymerase eta 0.0044 0.0128 0.0128
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0129 0.0485 0.2585
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0181 0.0704 0.1438
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.0704 0.1711
Leishmania major hypothetical protein, conserved 0.0181 0.0704 0.2481
Schistosoma mansoni hypothetical protein 0.1022 0.424 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0133
Brugia malayi Augmenter of liver regeneration 0.0035 0.009 0.0228
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0102 0.0372 0.5139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0646 0.266 0.751
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0047 0.0365
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0181 0.0704 0.1438
Mycobacterium ulcerans beta-lactamase 0.0181 0.0704 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0094
Loa Loa (eye worm) hypothetical protein 0.0056 0.0179 0.0506
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0035
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0129 0.0485 0.1751
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0025 0.0047 0.0047
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0025 0.0047 0.0061
Trypanosoma brucei hypothetical protein, conserved 0.0181 0.0704 0.3806
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0047 0.0133
Schistosoma mansoni hypothetical protein 0.0205 0.0803 0.1864
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0166 0.0641 0.2254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0205 0.0803 0.1039
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0129 0.0485 0.0485
Entamoeba histolytica hypothetical protein 0.0142 0.0542 1
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0056 0.0126
Onchocerca volvulus 0.0179 0.0695 0.1623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0025 0.0047 0.008
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0073 0.0249 0.4356
Toxoplasma gondii target of rapamycin (TOR), putative 0.0129 0.0485 0.679
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0646 0.266 0.7503
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0023 0.0001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0025 0.0047 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0047 0.0107
Leishmania major C-8 sterol isomerase-like protein 0.0445 0.1812 0.6518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.044 0.0569
Mycobacterium tuberculosis Probable esterase LipL 0.0181 0.0704 0.1438
Schistosoma mansoni hypothetical protein 0.0205 0.0803 0.1864
Echinococcus granulosus dnaJ subfamily B 0.0417 0.1695 0.2195
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0181 0.0704 0.1967
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0166 0.0641 0.2343
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0195 0.2535
Mycobacterium tuberculosis Conserved protein 0.0181 0.0704 0.1438
Echinococcus granulosus beta LACTamase domain containing family member 0.0181 0.0704 0.0911
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0144 0.0408
Loa Loa (eye worm) hypothetical protein 0.0081 0.0284 0.0801
Brugia malayi cytosol aminopeptidase 0.002 0.0029 0.0054
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.009 0.0257
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0047 0.0107
Schistosoma mansoni DNA polymerase eta 0.0044 0.0128 0.0267
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0144 0.0144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0704 0.1631
Loa Loa (eye worm) hypothetical protein 0.0025 0.0046 0.013
Echinococcus granulosus flap endonuclease 1 0.0027 0.0056 0.0072
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0022 0.0036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0129 0.0485 0.1346
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0704 0.1631
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0479
Loa Loa (eye worm) phosphatidylinositol kinase 0.0025 0.0047 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Schistosoma mansoni flap endonuclease-1 0.0024 0.0045 0.007
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0025 0.0047 0.0133
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0128 0.0335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.002 0.0029 0.0054
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0144 0.0306
Loa Loa (eye worm) hypothetical protein 0.0073 0.0249 0.0702
Onchocerca volvulus 0.0181 0.0704 0.1645
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1218 0.4527
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0025 0.0047 0.008
Leishmania major phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0091
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0025 0.0047 0.008
Plasmodium falciparum M17 leucyl aminopeptidase 0.0102 0.0372 1
Echinococcus granulosus GPCR family 2 0.0205 0.0803 0.1039
Leishmania major phosphatidylinositol 3-kinase, putative 0.0129 0.0485 0.1685
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.009 0.009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0205 0.0803 0.1039
Mycobacterium tuberculosis Probable lipase LipD 0.0181 0.0704 0.1438
Brugia malayi beta-lactamase family protein 0.0181 0.0704 0.1965
Onchocerca volvulus 0.0029 0.0066 0.0047
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0025 0.0047 0.0076
Entamoeba histolytica protein kinase rad3, putative 0.0073 0.0249 0.4356
Loa Loa (eye worm) hypothetical protein 0.0025 0.0047 0.0133
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0046 0.0347
Echinococcus granulosus ferritin 0.0017 0.0015 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0042 0.0092
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0129 0.0485 0.1751
Plasmodium vivax hypothetical protein 0.0025 0.0047 0.0365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0047 0.0107
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0181 0.0704 0.1988
Giardia lamblia DINP protein human, muc B family 0.0019 0.0023 0.0007
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0023 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0461 0.1056
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0025 0.0047 0.008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0025 0.0047 0.0076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0023 0.0001
Leishmania major phosphatidylinositol kinase related protein, putative 0.0025 0.0047 0.0091
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0122 0.0378
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0129 0.0485 0.2585
Schistosoma mansoni ap endonuclease 0.0019 0.0022 0.0017
Leishmania major mitochondrial DNA polymerase beta 0.0303 0.1218 0.4355
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0002
Brugia malayi Pre-SET motif family protein 0.0856 0.3541 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0025 0.0047 0.0076
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0073 0.0249 0.0857
Brugia malayi hypothetical protein 0.0179 0.0695 0.1941
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0047 0.0067
Onchocerca volvulus 0.0181 0.0704 0.1645
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0365
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0047 0.0133
Loa Loa (eye worm) hypothetical protein 0.0646 0.266 0.751
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0023 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0205 0.0803 0.2245
Entamoeba histolytica hypothetical protein 0.0073 0.0249 0.4356
Echinococcus multilocularis ferritin 0.0017 0.0015 0.0015
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.009 0.0255
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0102 0.0372 0.1325
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1851 0.7722 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0047 0.0061
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.009 0.1937
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0139
Trypanosoma cruzi Emopamil binding protein, putative 0.0166 0.0641 0.2343
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0144 0.0462
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0479
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0172 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Giardia lamblia GTOR 0.0129 0.0485 1
Onchocerca volvulus 0.0166 0.0641 0.1488
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0445 0.1812 0.6775
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0129 0.0485 0.2585
Trypanosoma cruzi target of rapamycin kinase 3 0.0129 0.0485 0.1751
Leishmania major hypothetical protein, unknown function 0.0025 0.0047 0.0091
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0172 0.0372
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.009 0.0117
Trypanosoma brucei unspecified product 0.0019 0.0023 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0047 0.0107
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0102 0.0372 0.1325
Schistosoma mansoni hypothetical protein 0.0056 0.0179 0.0388
Trypanosoma brucei Emopamil binding protein, putative 0.0166 0.0641 0.3458
Loa Loa (eye worm) hypothetical protein 0.0442 0.18 0.5083
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Entamoeba histolytica hypothetical protein 0.0025 0.0047 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Echinococcus multilocularis leucyl aminopeptidase 0.002 0.0029 0.0029
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0046 0.0132
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0018
Entamoeba histolytica hypothetical protein 0.0142 0.0542 1
Leishmania major DNA polymerase eta, putative 0.0044 0.0128 0.0384
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.0704 0.1711
Schistosoma mansoni hypothetical protein 0.1022 0.424 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0139
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0129 0.0485 0.1112
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0056 0.0487
Leishmania major DNA polymerase kappa, putative 0.0019 0.0023 0.0001
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0047 0.0365
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0073 0.0249 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0102 0.0372 0.0746
Leishmania major hypothetical protein, conserved 0.0035 0.009 0.0247
Loa Loa (eye worm) hypothetical protein 0.0123 0.0461 0.1303
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0046 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0023 0.0019
Entamoeba histolytica hypothetical protein 0.0025 0.0047 0.0479
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0056 0.0179 0.0179
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0094
Echinococcus multilocularis geminin 0.1022 0.424 0.424
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0047 0.0061
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0546 0.2928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0144 0.0321
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1851 0.7722 0.7722
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0144 0.0187
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0025 0.0047 0.008
Mycobacterium leprae Probable lipase LipE 0.0181 0.0704 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Brugia malayi Flap endonuclease-1 0.0027 0.0056 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0047 0.0466
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0073 0.0249 0.1264
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.009 0.0995
Echinococcus granulosus leucyl aminopeptidase 0.002 0.0029 0.0037
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.009 0.0995
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0122 0.0558
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0073 0.0249 0.0249
Entamoeba histolytica hypothetical protein 0.0025 0.0047 0.0479
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0056 0.0639
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0056 0.0487
Loa Loa (eye worm) aminopeptidase in chromosome III 0.002 0.0029 0.0081
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0144 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0023
Mycobacterium tuberculosis Probable hydrolase 0.0181 0.0704 0.1438
Echinococcus granulosus leucine aminopeptidase protein 0.0102 0.0372 0.0482
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0046 0.0676
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0479
Mycobacterium tuberculosis Conserved protein 0.0181 0.0704 0.1438
Brugia malayi mbt repeat family protein 0.0048 0.0144 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0704 0.0704
Brugia malayi Pre-SET motif family protein 0.0123 0.0461 0.1279
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0129 0.0485 0.1751
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0025 0.0047 0.008
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0129 0.0485 0.1685
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.0704 0.2579
Loa Loa (eye worm) hypothetical protein 0.0044 0.0128 0.0361
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0546 0.1984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0047 0.0107
Leishmania major hypothetical protein, conserved 0.0166 0.0641 0.2254
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0129 0.0485 0.0485
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0022 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0066 0.0186
Trichomonas vaginalis set domain proteins, putative 0.0974 0.4038 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0025 0.0047 0.0076
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0479
Loa Loa (eye worm) beta-lactamase 0.0181 0.0704 0.1987
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0047 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0284 0.0667
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0445 0.1812 0.5103
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0123 0.0461 0.1056
Echinococcus multilocularis Zinc finger, PHD finger 0.0025 0.0047 0.0047
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0025 0.0047 0.008
Loa Loa (eye worm) hypothetical protein 0.0181 0.0704 0.1987
Brugia malayi Calcitonin receptor-like protein seb-1 0.0646 0.266 0.7503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0022 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0073 0.0191
Echinococcus granulosus cpg binding protein 0.0031 0.0073 0.0095
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0047 0.0133
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0022 0.0203
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0129 0.0485 0.0628
Loa Loa (eye worm) hypothetical protein 0.0445 0.1812 0.5117
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0081 0.0284 0.3834
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0025 0.0047 0.0094
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0025 0.0047 0.0047
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0129 0.0485 0.8906
Trypanosoma brucei aminopeptidase, putative 0.002 0.0029 0.0035
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0056 0.0179 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0181 0.0704 0.0704
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.0753 0.0975
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0144 0.0144
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0025 0.0047 0.0139
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0094
Mycobacterium ulcerans lipase LipD 0.0181 0.0704 1
Echinococcus granulosus expressed protein 0.0017 0.0015 0.002
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0056 0.0056
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0023 0.0016
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0129 0.0485 0.1685
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0073 0.0249 0.0857
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.002 0.0029 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0303 0.1218 0.4527
Loa Loa (eye worm) latrophilin receptor protein 2 0.0205 0.0803 0.2266
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0161 0.0527
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.0365
Plasmodium vivax SET domain protein, putative 0.0123 0.0461 0.6445
Echinococcus granulosus serine protein kinase ATM 0.0073 0.0249 0.0322
Schistosoma mansoni transcription factor LCR-F1 0.0142 0.0542 0.1246
Trichomonas vaginalis esterase, putative 0.0181 0.0704 0.1711
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0179 0.0695 0.1963
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0122 0.0378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0025 0.0047 0.0047
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0181 0.0704 0.1987
Mycobacterium tuberculosis Conserved protein 0.0181 0.0704 0.1438
Schistosoma mansoni hypothetical protein 0.0205 0.0803 0.1864
Toxoplasma gondii leucyl aminopeptidase LAP 0.0102 0.0372 0.5139
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0023 0.0002
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0025 0.0047 0.0537
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0129 0.0485 0.1685
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0046 0.0347
Toxoplasma gondii ABC1 family protein 0.0181 0.0704 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Echinococcus granulosus geminin 0.1022 0.424 0.5491
Loa Loa (eye worm) hypothetical protein 0.0181 0.0704 0.1987
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0047 0.008
Leishmania major phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0091
Leishmania major hypothetical protein, conserved 0.0025 0.0046 0.0086
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.009 0.0379
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0025 0.0047 0.071
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0102 0.0372 0.1956
Echinococcus granulosus dna polymerase eta 0.0044 0.0128 0.0166
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0181 0.0704 0.1438
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0056 0.0718
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0205 0.0803 0.2245
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0479
Brugia malayi beta-lactamase 0.0181 0.0704 0.1965
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0128 0.059
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0025 0.0047 0.008
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0025 0.0047 0.0479
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0025 0.0047 0.0061
Entamoeba histolytica hypothetical protein 0.0142 0.0542 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0025 0.0047 0.0091
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0023 0.0016
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0025 0.0047 0.0094
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0046 0.0676
Brugia malayi FAT domain containing protein 0.0056 0.0179 0.0481
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.009 0.0995
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0056 0.0185
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0047 0.071
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0025 0.0047 0.0076
Mycobacterium ulcerans esterase/lipase LipP 0.0181 0.0704 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0025 0.0047 0.0365
Trypanosoma cruzi Emopamil binding protein, putative 0.0166 0.0641 0.2343
Echinococcus multilocularis 0.0025 0.0047 0.0047
Echinococcus granulosus leucyl aminopeptidase 0.002 0.0029 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0047 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0025 0.0047 0.0061
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0056 0.0121
Loa Loa (eye worm) hypothetical protein 0.0181 0.0704 0.1987
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0615 0.1252
Schistosoma mansoni fkbp-rapamycin associated protein 0.0073 0.0249 0.0553
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0166 0.0641 0.2343
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0284 0.0667
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0181 0.0704 1
Schistosoma mansoni hypothetical protein 0.0442 0.18 0.4225
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0129 0.0485 0.1346
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0022 0.0022
Echinococcus multilocularis cpg binding protein 0.0031 0.0073 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0025 0.0047 0.008
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0129 0.0485 0.2585
Schistosoma mansoni cpg binding protein 0.0031 0.0073 0.0137
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0856 0.3541 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0025 0.0047 0.0094
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.0704 0.1629
Onchocerca volvulus 0.0181 0.0704 0.1645
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0022 0.0105
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0129 0.0485 0.1751
Echinococcus multilocularis expressed protein 0.0017 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0181 0.0704 0.1987
Brugia malayi mbt repeat family protein 0.0048 0.0144 0.0382
Leishmania major DNA polymerase eta, putative 0.0031 0.0073 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0181 0.0704 0.1631
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0102 0.0372 0.519
Brugia malayi follicle stimulating hormone receptor 0.0241 0.0955 0.2678
Schistosoma mansoni hypothetical protein 0.0295 0.1183 0.2765
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0123 0.0461 0.0461
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0047 0.0094
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0129 0.0485 0.8906
Echinococcus multilocularis dnaJ subfamily B 0.0417 0.1695 0.1695
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0025 0.0047 0.0133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0129 0.0485 0.1112
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0029
Loa Loa (eye worm) aminopeptidase in chromosome V 0.002 0.0029 0.0081
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0129 0.0485 0.2585
Onchocerca volvulus 0.0123 0.0461 0.1038
Loa Loa (eye worm) MBCTL1 0.0055 0.0172 0.0486
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0303 0.1218 0.6681
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0181 0.0704 0.0912
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0025 0.0047 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0249 0.058
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0046 0.009
Mycobacterium ulcerans leucyl aminopeptidase 0.0102 0.0372 0.519
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0179 0.0408
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0073 0.0742
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0172 0.0172
Echinococcus granulosus dna polymerase kappa 0.0019 0.0023 0.0029
Echinococcus granulosus histone lysine methyltransferase setb 0.0123 0.0461 0.0598
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0025 0.0047 0.008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0025 0.0047 0.0479
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0142 0.0542 0.0702
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0142 0.0542 0.0542
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0023 0.0064
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.0704 0.1711
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0047 0.0139
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0102 0.0372 0.1275
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0144 0.0306
Giardia lamblia Hypothetical protein 0.0025 0.0047 0.0537
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.0753 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Trichomonas vaginalis penicillin-binding protein, putative 0.0181 0.0704 0.1711
Mycobacterium ulcerans hypothetical protein 0.016 0.0615 0.8708
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0023 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0442 0.18 0.507
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0022 0.0018
Trypanosoma cruzi hypothetical protein, conserved 0.0181 0.0704 0.2579
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0073 0.0249 0.0553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0461 0.1056
Toxoplasma gondii hypothetical protein 0.0049 0.0149 0.1853
Loa Loa (eye worm) hypothetical protein 0.0181 0.0704 0.1987
Mycobacterium ulcerans hypothetical protein 0.0181 0.0704 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0022 0.0029
Trypanosoma brucei C-8 sterol isomerase, putative 0.0445 0.1812 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0025 0.0047 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0123 0.0461 0.6445
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0144 0.0321
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0073 0.0249 0.0677
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0205 0.0803 0.0803
Onchocerca volvulus 0.0048 0.0144 0.0243
Brugia malayi hypothetical protein 0.0025 0.0046 0.0103
Schistosoma mansoni hypothetical protein 0.0205 0.0803 0.1864
Echinococcus multilocularis beta LACTamase domain containing family member 0.0181 0.0704 0.0704
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0123 0.0461 0.1056
Loa Loa (eye worm) hypothetical protein 0.0048 0.0144 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Loa Loa (eye worm) phosphatidylinositol 3 0.0129 0.0485 0.1369
Brugia malayi hypothetical protein 0.0142 0.0542 0.1507
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0025 0.0047 0.008
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0129 0.0485 0.0628
Brugia malayi beta-lactamase family protein 0.0181 0.0704 0.1965
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0023 0.0037
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0144 0.0243
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0181 0.0704 0.1629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0129 0.0485 0.1168
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.0955 0.2697
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0023 0.0023
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.002 0.0029 0.0054
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0025 0.0047 0.0047
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0025 0.0047 0.0537
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1156 0.4802 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0025 0.0047 0.0107
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0144 0.0306
Echinococcus multilocularis serine protein kinase ATM 0.0073 0.0249 0.0249
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.002 0.0029 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0181 0.0704 0.1711

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.48 nM Displacement of [3H]pentazocine from Sigma1 receptor in guinea pig brain membrane ChEMBL. 17713896
Ki (binding) = 55 nM Displacement of [3H]emopamil from Delta(8)-Delta(7) sterol isomerase in guinea pig liver membrane ChEMBL. 17713896

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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