Detailed information for compound 1030545

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 328.033 | Formula: C10H13BrCl2N2O
  • H donors: 1 H acceptors: 1 LogP: 3.22 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC1(CC1)COc1cnc(c(c1)Br)Cl.Cl
  • InChi: 1S/C10H12BrClN2O.ClH/c1-13-10(2-3-10)6-15-7-4-8(11)9(12)14-5-7;/h4-5,13H,2-3,6H2,1H3;1H
  • InChiKey: YPOSIEIAGHFMLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor protein alpha-7 subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum ko:K04809 cholinergic receptor, nicotinic, alpha 7, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Onchocerca volvulus Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum IPR006201,Neurotransmitter-gated ion-channel;IPR006029,Neurotransmitter-gated ion-channel transmembrane region,domain-containing Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) Get druggable targets OG5_130932 All targets in OG5_130932
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-7 precursor, putative Get druggable targets OG5_130932 All targets in OG5_130932
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130932 All targets in OG5_130932
Brugia malayi Cation transporter family protein Get druggable targets OG5_130932 All targets in OG5_130932
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 486 aa 32.9 %
Echinococcus multilocularis nAChR subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 488 aa 27.9 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 530 aa 29.6 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 484 aa 34.3 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 519 aa 25.6 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 513 aa 35.5 %
Loa Loa (eye worm) hypothetical protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 491 aa 36.0 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 496 aa 35.5 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 501 aa 36.5 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 482 aa 42.9 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 543 aa 27.8 %
Onchocerca volvulus Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 552 aa 24.3 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 475 aa 36.8 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 527 aa 33.6 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 501 aa 32.1 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 511 aa 27.2 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 485 aa 32.6 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 513 aa 35.5 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 510 aa 36.1 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 511 aa 36.0 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 508 aa 38.6 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 486 aa 33.1 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 507 aa 35.3 %
Onchocerca volvulus Putative zinc finger protein Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 515 aa 36.9 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 497 aa 35.0 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Neuronal acetylcholine receptor protein alpha-7 subunit   502 aa 518 aa 24.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0195 0.0584 0.0584
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0015 0.0009 0.0023
Echinococcus granulosus g protein coupled receptor 0.021 0.0631 0.0631
Echinococcus multilocularis acetylcholinesterase 0.007 0.0186 0.0186
Loa Loa (eye worm) neuropeptide F receptor 0.021 0.0631 0.3602
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0028 0.0136
Echinococcus multilocularis g protein coupled receptor 0.021 0.0631 0.0631
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0015 0.0009 0.0023
Onchocerca volvulus 0.021 0.0631 0.7367
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0429 0.0429
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0015 0.0009 0.0023
Brugia malayi sulfakinin receptor protein 0.021 0.0631 0.3062
Onchocerca volvulus 0.0195 0.0584 0.6817
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0088 0.2116
Onchocerca volvulus 0.021 0.0631 0.7367
Brugia malayi Cytochrome P450 family protein 0.0034 0.0072 0.0349
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0561 0.1752 0.1752
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0414
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0195 0.0584 0.2833
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Echinococcus granulosus G protein coupled receptor 139 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis alpha 1A adrenergic receptor 0.021 0.0631 0.0631
Echinococcus multilocularis neuropeptide Y receptor 0.021 0.0631 0.0631
Schistosoma mansoni lamin 0.0029 0.0055 0.0236
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0195 0.0584 0.0584
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0099 0.1412
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0561 0.1752 0.7457
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0038 1
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0095 0.0405
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0195 0.0584 0.2833
Brugia malayi putative neuropeptide receptor NPR1 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.7478
Onchocerca volvulus 0.0195 0.0584 0.6817
Mycobacterium ulcerans naphthoate synthase 0.124 0.3916 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0195 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0031
Onchocerca volvulus Neuropeptide F receptor homolog 0.021 0.0631 0.7367
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0015 0.0009 0.0023
Schistosoma mansoni hypothetical protein 0.0561 0.1752 0.7457
Brugia malayi Pre-SET motif family protein 0.0204 0.0614 0.2982
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.028 0.0856 0.4889
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0056 0.0237
Echinococcus multilocularis sex peptide receptor 0.021 0.0631 0.0631
Echinococcus multilocularis survival motor neuron protein 1 0.0261 0.0794 0.0794
Echinococcus granulosus tm gpcr rhodopsin 0.021 0.0631 0.0631
Echinococcus granulosus glycine receptor subunit alpha 1 0.0195 0.0584 0.0584
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0028 0.0072
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis g protein coupled receptor 0.021 0.0631 0.0631
Onchocerca volvulus 0.021 0.0631 0.7367
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0056 0.0056
Brugia malayi Dopamine receptor 0.021 0.0631 0.3062
Echinococcus granulosus neuropeptides capa receptor 0.021 0.0631 0.0631
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0195 0.0584 0.2833
Brugia malayi Serotonin/octopamine receptor family protein 7 0.021 0.0631 0.3062
Echinococcus granulosus neuropeptide receptor 0.021 0.0631 0.0631
Echinococcus granulosus carboxylesterase 5A 0.007 0.0186 0.0186
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0015 0.0009 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.021 0.0631 0.0631
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0028 0.0398
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Schistosoma mansoni neuropeptide F-like receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni apoptosis regulator bax 0.0561 0.1752 0.7457
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0015 0.0009 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.0584 0.2833
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.021 0.0631 0.3602
Onchocerca volvulus 0.021 0.0631 0.7367
Brugia malayi ORL1-like opioid receptor 0.021 0.0631 0.3062
Echinococcus granulosus tm gpcr rhodopsin 0.021 0.0631 0.0631
Onchocerca volvulus 0.021 0.0631 0.7367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0292 0.1242
Brugia malayi Cation transporter family protein 0.0195 0.0584 0.2833
Onchocerca volvulus Putative nachr subunit 0.0195 0.0584 0.6817
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0015 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Echinococcus multilocularis neuropeptide Y receptor 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.021 0.0631 0.3602
Brugia malayi Carboxylesterase family protein 0.007 0.0186 0.0903
Schistosoma mansoni cytochrome P450 0.0015 0.0009 0.0038
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0055 0.0269
Echinococcus granulosus tm gpcr rhodopsin 0.021 0.0631 0.0631
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0028 0.0028
Onchocerca volvulus 0.021 0.0631 0.7367
Schistosoma mansoni acetylcholine receptor-related 0.0085 0.0234 0.0998
Loa Loa (eye worm) melatonin receptor type 1A 0.021 0.0631 0.3602
Brugia malayi Cation transporter family protein 0.028 0.0856 0.4156
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.021 0.0631 0.3602
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.011 0.0312 0.1512
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.021 0.0631 0.0631
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0099 0.1412
Schistosoma mansoni biogenic amine (dopamine) receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0195 0.0584 0.3332
Brugia malayi Serotonin receptor 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Leishmania major cytochrome p450-like protein 0.0024 0.0038 1
Onchocerca volvulus 0.021 0.0631 0.7367
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.021 0.0631 0.3062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0292 0.1242
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Echinococcus granulosus lamin dm0 0.0029 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0015 0.0009 0.0023
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0015 0.0009 0.0023
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0015 0.0009 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.7478
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0195 0.0584 0.0584
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.021 0.0631 0.3062
Loa Loa (eye worm) G-protein coupled receptor 0.021 0.0631 0.3602
Brugia malayi larval opioid receptor 0.021 0.0631 0.3062
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.021 0.0631 0.2686
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0076 0.1078
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.007 0.0186 0.1062
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0056 0.0056
Brugia malayi G-protein coupled receptor 0.021 0.0631 0.3062
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0015 0.0009 0.0023
Schistosoma mansoni neuropeptide f receptor 76f 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.021 0.0631 0.2686
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Onchocerca volvulus 0.0233 0.0704 0.8226
Echinococcus multilocularis conserved hypothetical protein 0.0672 0.2106 0.2106
Onchocerca volvulus 0.028 0.0856 1
Brugia malayi Dopamine receptor protein 2 0.021 0.0631 0.3062
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0099 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.021 0.0631 0.0631
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.021 0.0631 0.3602
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.0584 0.2833
Loa Loa (eye worm) TYRA-2 protein 0.021 0.0631 0.3602
Schistosoma mansoni hypothetical protein 0.0053 0.0132 0.0562
Echinococcus multilocularis neuropeptide receptor A26 0.1666 0.5275 0.5275
Echinococcus granulosus orexin receptor type 2 0.021 0.0631 0.0631
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.021 0.0631 0.0631
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0085 0.0234 0.0234
Echinococcus granulosus importin subunit beta 1 0.0029 0.0055 0.0055
Plasmodium vivax SET domain protein, putative 0.0029 0.0056 0.3873
Echinococcus granulosus 7tm_1 domain containing protein 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3335
Brugia malayi intermediate filament protein 0.0029 0.0055 0.0269
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0195 0.0584 0.0584
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0015 0.0009 0.0023
Onchocerca volvulus 0.021 0.0631 0.7367
Echinococcus multilocularis neuropeptide receptor 0.021 0.0631 0.0631
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0028 0.6619
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0056 0.0237
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) ACC-1 protein 0.0195 0.0584 0.3332
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni histamine h1 receptor 0.021 0.0631 0.2686
Schistosoma mansoni hypothetical protein 0.0561 0.1752 0.7457
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus 7TM GPCR rhodopsin 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.007 0.0186 0.1062
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0148
Echinococcus granulosus acetylcholinesterase 0.007 0.0186 0.0186
Schistosoma mansoni neurotransmitter gated ion channel 0.011 0.0312 0.1326
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) ACC-1 protein 0.0195 0.0584 0.3332
Onchocerca volvulus 0.021 0.0631 0.7367
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus alpha 1A adrenergic receptor 0.021 0.0631 0.0631
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0028 0.6619
Onchocerca volvulus 0.0053 0.0132 0.1541
Loa Loa (eye worm) neuropeptide F receptor 0.021 0.0631 0.3602
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0015 0.0009 0.0023
Echinococcus granulosus snurportin 1 0.0311 0.0954 0.0954
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0561 0.1752 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0028 0.5
Echinococcus granulosus fmrfamide receptor 0.021 0.0631 0.0631
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0038 0.0532
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0041
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.021 0.0631 0.2686
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0015 0.0009 0.0023
Leishmania major GTP-binding protein, putative 0.0021 0.0031 0.7478
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0174
Schistosoma mansoni neuropeptide receptor 0.021 0.0631 0.2686
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0015 0.0009 0.0023
Echinococcus multilocularis allatostatin A receptor 0.021 0.0631 0.0631
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0028 0.0398
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0195 0.0584 0.0584
Echinococcus granulosus serotonin receptor 0.021 0.0631 0.0631
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0429 0.1827
Loa Loa (eye worm) acetylcholinesterase 1 0.007 0.0186 0.1062
Plasmodium vivax importin-beta 2, putative 0.0029 0.0055 0.3781
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0015 0.0009 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0028 0.016
Echinococcus multilocularis neuropeptides capa receptor 0.021 0.0631 0.0631
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0195 0.0584 0.0584
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0031 0.2388
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0028 0.0028
Loa Loa (eye worm) apoptosis regulator protein 0.0561 0.1752 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.0584 0.2833
Schistosoma mansoni ran 0.0021 0.0031 0.013
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0015 0.0009 0.0023
Echinococcus granulosus g protein coupled receptor 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni amine GPCR 0.021 0.0631 0.2686
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Schistosoma mansoni ap endonuclease 0.0021 0.0028 0.0119
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0031
Schistosoma mansoni microtubule-associated protein tau 0.0748 0.2349 1
Schistosoma mansoni biogenic amine receptor 0.021 0.0631 0.2686
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0088 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.021 0.0631 0.0631
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0015 0.0009 0.0023
Entamoeba histolytica hypothetical protein 0.011 0.0312 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0056 0.0056
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0311 0.0954 0.4061
Schistosoma mansoni hypothetical protein 0.0561 0.1752 0.7457
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0015 0.0009 0.0023
Echinococcus multilocularis biogenic amine (5HT) receptor 0.021 0.0631 0.0631
Brugia malayi follicle stimulating hormone receptor 0.021 0.0631 0.3062
Brugia malayi G-protein coupled receptor 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0314
Onchocerca volvulus 0.0029 0.0056 0.0651
Echinococcus granulosus neuropeptide receptor 0.021 0.0631 0.0631
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.0292 0.1665
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0085 0.0234 0.0234
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0055 1
Echinococcus multilocularis neuropeptide receptor 0.021 0.0631 0.0631
Echinococcus multilocularis 0.0015 0.0009 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.1666 0.5275 0.5275
Onchocerca volvulus 0.0085 0.0234 0.2736
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0015 0.0009 0.0023
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0015 0.0009 0.0023
Schistosoma mansoni opsin-like receptor 0.021 0.0631 0.2686
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0015 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.021 0.0631 0.2686
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0195 0.0584 0.2833
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.0084 0.0479
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0234 0.1137
Schistosoma mansoni growth hormone secretagogue receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) follicle stimulating hormone receptor 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0015 0.0009 0.0023
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0195 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.0292 0.1242
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0561 0.1752 0.8502
Onchocerca volvulus 0.021 0.0631 0.7367
Schistosoma mansoni hypothetical protein 0.021 0.0631 0.2686
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0099 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0312 0.1512
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.021 0.0631 0.2686
Schistosoma mansoni amine GPCR 0.021 0.0631 0.2686
Brugia malayi hypothetical protein 0.0085 0.0234 0.1137
Onchocerca volvulus 0.021 0.0631 0.7367
Brugia malayi hypothetical protein 0.0261 0.0794 0.3856
Schistosoma mansoni opsin-like receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Schistosoma mansoni neurotransmitter gated ion channel 0.0085 0.0234 0.0998
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.021 0.0631 0.0631
Schistosoma mansoni amine GPCR 0.021 0.0631 0.2686
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0195 0.0584 0.2485
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0195 0.0584 0.3332
Onchocerca volvulus 0.028 0.0856 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.011 0.0312 0.1512
Echinococcus multilocularis glycine receptor subunit beta 0.0195 0.0584 0.0584
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0429 0.2083
Onchocerca volvulus 0.021 0.0631 0.7367
Loa Loa (eye worm) LGC-31 protein 0.0195 0.0584 0.3332
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.0954 0.5445
Schistosoma mansoni neuropeptide receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Loa Loa (eye worm) hypothetical protein 0.0029 0.0056 0.0318
Loa Loa (eye worm) GABA receptor subunit 0.011 0.0312 0.1779
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0195 0.0584 0.0584
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0015 0.0009 0.0023
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.021 0.0631 0.0631
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0038 0.6267
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus neuropeptide Y receptor 0.021 0.0631 0.0631
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0414
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0532
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0195 0.0584 0.0584
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0095 0.0405
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0195 0.0584 0.0584
Schistosoma mansoni amine GPCR 0.021 0.0631 0.2686
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0292 0.0292
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.0614 0.3507
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0234 0.1137
Onchocerca volvulus 0.021 0.0631 0.7367
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0088 1
Echinococcus granulosus neuropeptide s receptor 0.1666 0.5275 0.5275
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0195 0.0584 0.3332
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.3147 1 1
Brugia malayi hypothetical protein 0.0085 0.0234 0.1137
Onchocerca volvulus 0.021 0.0631 0.7367
Schistosoma mansoni neuropeptide F-like receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus sex peptide receptor 0.021 0.0631 0.0631
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.011 0.0312 0.1326
Echinococcus granulosus peptide allatostatin:somatostatin 0.021 0.0631 0.0631
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0195 0.0584 0.2833
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Onchocerca volvulus 0.011 0.0312 0.3639
Trichomonas vaginalis set domain proteins, putative 0.0233 0.0704 1
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0085 0.0234 0.1137
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Mycobacterium tuberculosis Naphthoate synthase MenB (dihydroxynaphthoic acid synthetase) (DHNA synthetase) 0.124 0.3916 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.0084 0.0084
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0015 0.0009 0.0023
Echinococcus granulosus intermediate filament protein 0.0029 0.0055 0.0055
Mycobacterium leprae PROBABLE NAPHTHOATE SYNTHASE MENB (DIHYDROXYNAPHTHOIC ACID SYNTHETASE) (DHNA SYNTHETASE) 0.124 0.3916 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.021 0.0631 0.0631
Echinococcus multilocularis nAChR subunit 0.011 0.0312 0.0312
Echinococcus multilocularis tachykinin peptides receptor 99D 0.021 0.0631 0.0631
Echinococcus granulosus lamin 0.0029 0.0055 0.0055
Echinococcus granulosus neuropeptide FF receptor 2 0.021 0.0631 0.0631
Schistosoma mansoni alpha-1 adrenergic receptor 0.021 0.0631 0.2686
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Echinococcus multilocularis microtubule associated protein 2 0.0748 0.2349 0.2349
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Echinococcus multilocularis orexin receptor type 2 0.021 0.0631 0.0631
Echinococcus multilocularis musashi 0.0029 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0195 0.0584 0.2833
Echinococcus granulosus neuropeptides capa receptor 0.021 0.0631 0.0631
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0028 0.4149
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.028 0.0856 0.3646
Onchocerca volvulus 0.0029 0.0055 0.0648
Echinococcus granulosus hypothetical protein 0.0882 0.2775 0.2775
Echinococcus multilocularis glycine receptor subunit beta 0.0195 0.0584 0.0584
Echinococcus granulosus somatostatin receptor 0.021 0.0631 0.0631
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.0292 0.1416
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0015 0.0009 0.0023
Loa Loa (eye worm) hypothetical protein 0.028 0.0856 0.4889
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0292 0.0292
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.0584 0.2833
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0195 0.0584 0.2833
Brugia malayi AKH receptor 0.021 0.0631 0.3062
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0015 0.0009 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0055 0.0317
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Brugia malayi Cytochrome P450 family protein 0.0024 0.0038 0.0184
Schistosoma mansoni hypothetical protein 0.0015 0.0009 0.0038
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0195 0.0584 0.2833
Loa Loa (eye worm) hypothetical protein 0.0033 0.0068 0.0388
Onchocerca volvulus 0.0085 0.0234 0.2736
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0015 0.0009 0.0023
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.011 0.0312 0.1512
Echinococcus multilocularis acetylcholinesterase 0.007 0.0186 0.0186
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.021 0.0631 0.2686
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0195 0.0584 0.2485
Brugia malayi Cation transporter family protein 0.0195 0.0584 0.2833
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Schistosoma mansoni neurotransmitter gated ion channel 0.0085 0.0234 0.0998
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.021 0.0631 0.0631
Schistosoma mansoni adenoreceptor 0.021 0.0631 0.2686
Schistosoma mansoni nAChR subunit 0.0085 0.0234 0.0998
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0038 0.0216
Brugia malayi hypothetical protein 0.0085 0.0234 0.1137
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0195 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Schistosoma mansoni biogenic amine (5HT) receptor 0.021 0.0631 0.2686
Schistosoma mansoni survival motor neuron protein 0.0053 0.0132 0.0562
Brugia malayi RNA, U transporter 1 0.0083 0.0226 0.1098
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0028 0.5
Echinococcus multilocularis lamin dm0 0.0029 0.0055 0.0055
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0015 0.0009 0.0023
Echinococcus multilocularis fmrfamide receptor 0.021 0.0631 0.0631
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0038 1
Echinococcus multilocularis dro:myosuppressin receptor 0.021 0.0631 0.0631
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0195 0.0584 0.2485
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Echinococcus granulosus allatostatin A receptor 0.021 0.0631 0.0631
Echinococcus multilocularis fmrfamide receptor 0.021 0.0631 0.0631
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0038 0.0216
Echinococcus granulosus microtubule associated protein 2 0.0748 0.2349 0.2349
Echinococcus granulosus biogenic amine 5HT receptor 0.021 0.0631 0.0631
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0015 0.0009 0.0023
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0038 0.0097
Echinococcus granulosus neuropeptide Y receptor 0.021 0.0631 0.0631
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0307
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.021 0.0631 0.0631
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0085 0.0234 0.1338
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Brugia malayi Pre-SET motif family protein 0.0029 0.0056 0.027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0028 0.6619
Schistosoma mansoni opsin-like receptor 0.021 0.0631 0.2686
Brugia malayi GnHR receptor homolog 0.021 0.0631 0.3062
Onchocerca volvulus 0.0085 0.0234 0.2736
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.007 0.0186 0.0792
Echinococcus multilocularis lamin 0.0029 0.0055 0.0055
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0055 0.0317
Echinococcus multilocularis carboxylesterase 5A 0.007 0.0186 0.0186
Brugia malayi cytochrome P450 0.0015 0.0009 0.0043
Schistosoma mansoni acetylcholine receptor subunit beta 0.0085 0.0234 0.0998
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Schistosoma mansoni myosin xvIII 0.021 0.0631 0.2686
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0195 0.0584 0.0584
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0052 0.0052
Brugia malayi Tachykinin-like peptides receptor 99D 0.021 0.0631 0.3062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.0084 0.0084
Schistosoma mansoni ap endonuclease 0.0021 0.0028 0.0119
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0195 0.0584 0.2833
Loa Loa (eye worm) hypothetical protein 0.0261 0.0794 0.4536
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0085 0.0234 0.1137
Brugia malayi neuropeptide F receptor 0.021 0.0631 0.3062
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Trichomonas vaginalis ran, putative 0.0021 0.0031 0.0434
Loa Loa (eye worm) hypothetical protein 0.011 0.0312 0.1779
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.011 0.0312 0.1326
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.0416 0.0416
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni biogenic amine (dopamine) receptor 0.021 0.0631 0.2686
Brugia malayi Cytochrome P450 family protein 0.0015 0.0009 0.0043
Onchocerca volvulus 0.0195 0.0584 0.6817
Brugia malayi gonadotropin-releasing hormone receptor 2 0.021 0.0631 0.3062
Echinococcus granulosus glycine receptor subunit alpha 1 0.0195 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Brugia malayi putative neuropeptide receptor 0.021 0.0631 0.3062
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.0292 0.0292
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0056 0.5168
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Schistosoma mansoni neuropeptide receptor 0.021 0.0631 0.2686
Schistosoma mansoni neuropeptide receptor 0.021 0.0631 0.2686
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.021 0.0631 0.0631
Schistosoma mansoni biogenic amine receptor 0.021 0.0631 0.2686
Schistosoma mansoni hypothetical protein 0.021 0.0631 0.2686
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0055 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0195 0.0584 0.3332
Brugia malayi hypothetical protein 0.0085 0.0234 0.1137
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0085 0.0234 0.0234
Schistosoma mansoni peptide (allatostatin)-like receptor 0.021 0.0631 0.2686
Echinococcus granulosus tachykinin peptides receptor 99D 0.021 0.0631 0.0631
Echinococcus granulosus glycine receptor subunit alpha 1 0.0195 0.0584 0.0584
Echinococcus granulosus thyrotropin releasing hormone receptor 0.021 0.0631 0.0631
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0031 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0056 0.0237
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0038 0.9883
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0195 0.0584 0.3332
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0015 0.0009 0.0023
Echinococcus granulosus g-protein coupled receptor 0.021 0.0631 0.0631
Toxoplasma gondii exonuclease III APE 0.0021 0.0028 0.2114
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Loa Loa (eye worm) carboxylesterase 0.007 0.0186 0.1062
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0056 0.0237
Loa Loa (eye worm) acetyltransferase 0.0146 0.0429 0.245
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0076 0.1078
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0195 0.0584 0.0584
Echinococcus granulosus glycine receptor subunit beta 0.0195 0.0584 0.0584
Echinococcus multilocularis G protein coupled receptor 139 0.021 0.0631 0.0631
Plasmodium falciparum importin beta, putative 0.0029 0.0055 0.4502
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0015 0.0009 0.0023
Schistosoma mansoni lamin 0.0029 0.0055 0.0236
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0015 0.0009 0.0023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.0584 0.2833
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Brugia malayi excitatory GABA receptor EXP-1A 0.0195 0.0584 0.2833
Entamoeba histolytica hypothetical protein 0.0024 0.0038 0.0333
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni ran 0.0021 0.0031 0.013
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0195 0.0584 0.0584
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.028 0.0856 0.3646
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0038 0.0216
Loa Loa (eye worm) G-protein coupled receptor 0.021 0.0631 0.3602
Echinococcus granulosus acetylcholinesterase 0.007 0.0186 0.0186
Schistosoma mansoni biogenic amine receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0195 0.0584 0.3332
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.0084 0.0408
Onchocerca volvulus 0.021 0.0631 0.7367
Onchocerca volvulus 0.011 0.0312 0.3639
Onchocerca volvulus 0.021 0.0631 0.7367
Echinococcus multilocularis g protein coupled receptor 0.021 0.0631 0.0631
Schistosoma mansoni amine GPCR 0.0532 0.166 0.7068
Echinococcus multilocularis g-protein coupled receptor 0.021 0.0631 0.0631
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.021 0.0631 0.2686
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0031 0.0031
Leishmania major importin beta-1 subunit, putative 0.0024 0.0038 0.9883
Brugia malayi G protein-coupled receptor 0.021 0.0631 0.3062
Brugia malayi G protein-coupled receptor F59B2.13 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Schistosoma mansoni hypothetical protein 0.021 0.0631 0.2686
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0085 0.0234 0.0234
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0055 0.5096
Echinococcus multilocularis nAChR subunit 0.0195 0.0584 0.0584
Echinococcus multilocularis G-protein coupled receptor, putative 0.021 0.0631 0.0631
Schistosoma mansoni importin beta-1 0.0029 0.0055 0.0234
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Echinococcus granulosus glycine receptor subunit beta 0.0195 0.0584 0.0584
Schistosoma mansoni hypothetical protein 0.021 0.0631 0.2686
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Brugia malayi Serotonin receptor 0.0658 0.206 1
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis neuropeptides capa receptor 0.021 0.0631 0.0631
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Loa Loa (eye worm) hypothetical protein 0.0085 0.0234 0.1338
Loa Loa (eye worm) cytochrome P450 0.0015 0.0009 0.0051
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis somatostatin receptor 0.021 0.0631 0.0631
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0015 0.0009 0.0023
Schistosoma mansoni intermediate filament proteins 0.0029 0.0055 0.0236
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus nAChR subunit 0.011 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0195 0.0584 0.2485
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.021 0.0631 0.0631
Brugia malayi Dopamine receptor protein 1 0.021 0.0631 0.3062
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0053 0.0132 0.0641
Entamoeba histolytica Ran family GTPase 0.0021 0.0031 0.0088
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.4686
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0195 0.0584 0.2833
Brugia malayi Carboxylesterase family protein 0.007 0.0186 0.0903
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0012 0.0069
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.021 0.0631 0.3062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Echinococcus multilocularis neuropeptide FF receptor 2 0.021 0.0631 0.0631
Brugia malayi Cytochrome P450 family protein 0.0024 0.0038 0.0184
Brugia malayi neuropeptide F receptor 0.021 0.0631 0.3062
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0028 0.0072
Brugia malayi Melatonin receptor type 1A 0.021 0.0631 0.3062
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0195 0.0584 0.0584
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0015 0.0009 0.0023
Brugia malayi hypothetical protein 0.0085 0.0234 0.1137
Onchocerca volvulus 0.0029 0.0055 0.0648
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0561 0.1752 0.1752
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0009 0.0009
Brugia malayi Importin beta-1 subunit 0.0029 0.0055 0.0267
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.0292 0.0292
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.021 0.0631 0.0631
Echinococcus multilocularis rhodopsin orphan GPCR 0.021 0.0631 0.0631
Schistosoma mansoni nAChR subunit 0.0085 0.0234 0.0998
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0099 1
Echinococcus granulosus dro:myosuppressin receptor 0.021 0.0631 0.0631
Echinococcus multilocularis snurportin 1 0.0311 0.0954 0.0954
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus nAChR subunit 0.0195 0.0584 0.0584
Schistosoma mansoni rhodopsin-like orphan GPCR 0.021 0.0631 0.2686
Onchocerca volvulus 0.028 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Schistosoma mansoni nAChR subunit 0.0195 0.0584 0.2485
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0879 0.2767 0.2767
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0195 0.0584 0.2833
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0015 0.0009 0.0023
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0012 0.0059
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.021 0.0631 0.2686
Echinococcus granulosus rhodopsin orphan GPCR 0.021 0.0631 0.0631
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0085 0.0234 0.1137
Brugia malayi hypothetical protein 0.021 0.0631 0.3062
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0015 0.0009 0.0023
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0015 0.0009 0.0023
Onchocerca volvulus 0.021 0.0631 0.7367
Echinococcus multilocularis neuropeptide s receptor 0.1666 0.5275 0.5275
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0085 0.0234 0.1137
Loa Loa (eye worm) hypothetical protein 0.0195 0.0584 0.3332
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0085 0.0234 0.0234
Brugia malayi RE15519p 0.021 0.0631 0.3062
Loa Loa (eye worm) acetylcholine receptor protein 0.0085 0.0234 0.1338
Echinococcus multilocularis serotonin receptor 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.0029 0.0055 0.0317
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus multilocularis serotonin receptor 0.021 0.0631 0.0631
Echinococcus granulosus survival motor neuron protein 1 0.0261 0.0794 0.0794
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0195 0.0584 0.0584
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.021 0.0631 0.0631
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0038 0.0532
Schistosoma mansoni biogenic amine (5HT) receptor 0.021 0.0631 0.2686
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0072 0.0411
Echinococcus granulosus biogenic amine 5HT receptor 0.021 0.0631 0.0631
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0015 0.0009 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0015 0.0009 0.0023
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0195 0.0584 0.0584
Loa Loa (eye worm) hypothetical protein 0.021 0.0631 0.3602
Echinococcus granulosus g protein coupled receptor 0.021 0.0631 0.0631
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.021 0.0631 0.7367

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.37 nM Displacement of [3H]cystisine from nicotinic alpha4beta2 receptor in rat brain ChEMBL. 18262785
Ki (binding) > 10000 nM Displacement of [3H]alpha-bungaro-toxine from nicotinic alpha7 receptor in rat brain ChEMBL. 18262785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.