Detailed information for compound 1046754

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 280.793 | Formula: C15H21ClN2O
  • H donors: 1 H acceptors: 1 LogP: 2.99 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1C)NC1CN2CCC1CC2.Cl
  • InChi: 1S/C15H20N2O.ClH/c1-11-4-2-3-5-13(11)15(18)16-14-10-17-8-6-12(14)7-9-17;/h2-5,12,14H,6-10H2,1H3,(H,16,18);1H
  • InChiKey: HBGWOVQMYJAPIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Serotonin 3 (5-HT3) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cation transporter family protein Serotonin 3 (5-HT3) receptor   483 aa 507 aa 28.2 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 27.7 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Serotonin 3 (5-HT3) receptor   483 aa 541 aa 25.5 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 505 aa 21.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 465 aa 27.3 %
Onchocerca volvulus Large subunit GTPase 1 homolog Serotonin 3 (5-HT3) receptor   483 aa 394 aa 19.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 473 aa 27.5 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 463 aa 26.8 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Serotonin 3 (5-HT3) receptor   483 aa 387 aa 25.6 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-9-II precursor, putative Serotonin 3 (5-HT3) receptor   483 aa 457 aa 24.7 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.6 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 452 aa 29.2 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Serotonin 3 (5-HT3) receptor   483 aa 482 aa 25.1 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 470 aa 26.8 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Serotonin 3 (5-HT3) receptor   483 aa 514 aa 23.2 %
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein Serotonin 3 (5-HT3) receptor   483 aa 388 aa 21.9 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.9 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Serotonin 3 (5-HT3) receptor   483 aa 478 aa 25.1 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Serotonin 3 (5-HT3) receptor   483 aa 503 aa 22.3 %
Echinococcus multilocularis nAChR subunit Serotonin 3 (5-HT3) receptor   483 aa 495 aa 24.2 %
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 457 aa 26.7 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 484 aa 26.0 %
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Serotonin 3 (5-HT3) receptor   483 aa 490 aa 31.0 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Serotonin 3 (5-HT3) receptor   483 aa 482 aa 23.9 %
Onchocerca volvulus Putative zinc finger protein Serotonin 3 (5-HT3) receptor   483 aa 489 aa 25.8 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 489 aa 31.3 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 477 aa 26.6 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Serotonin 3 (5-HT3) receptor   483 aa 445 aa 25.4 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type des-2 homolog Serotonin 3 (5-HT3) receptor   483 aa 464 aa 24.8 %
Onchocerca volvulus Serotonin 3 (5-HT3) receptor   483 aa 461 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0054 0.019 0.3386
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Echinococcus granulosus geminin 0.0862 0.5208 0.8502
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0015 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Echinococcus multilocularis cathepsin L cysteine protease 0.0295 0.169 0.169
Brugia malayi Papain family cysteine protease containing protein 0.0134 0.069 0.1126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0461 0.0752
Loa Loa (eye worm) hypothetical protein 0.0031 0.0051 0.0084
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0508 0.1169
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.058 0.1337
Giardia lamblia Cathepsin L-like protease 0.009 0.0415 0.1901
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.0677
Onchocerca volvulus 0.0295 0.169 0.8852
Schistosoma mansoni ap endonuclease 0.0055 0.02 0.0326
Loa Loa (eye worm) hypothetical protein 0.0034 0.0066 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Trypanosoma brucei oligopeptidase b 0.0054 0.019 0.0869
Schistosoma mansoni cathepsin F (C01 family) 0.0251 0.1415 0.231
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0054 0.019 0.0435
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0721 0.4333 1
Plasmodium vivax serine-repeat antigen (SERA) 0.009 0.0415 0.2454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.169 0.2759
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Giardia lamblia Cathepsin B precursor 0.0374 0.2181 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0558 0.1869
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.101 0.6126 1
Entamoeba histolytica cysteine protease, putative 0.009 0.0415 0.2454
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0054 0.019 0.0309
Toxoplasma gondii cathepsin CPC2 0.009 0.0415 0.1901
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0295 0.169 0.5663
Echinococcus multilocularis beta LACTamase domain containing family member 0.0113 0.0558 0.0558
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.1386 0.2263
Brugia malayi Cathepsin L-like precursor 0.0295 0.169 0.2759
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Plasmodium falciparum serine repeat antigen 3 0.009 0.0415 0.2454
Echinococcus multilocularis snurportin 1 0.0333 0.1926 0.1926
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0055 0.02 0.0326
Entamoeba histolytica cysteine proteinase 2 0.0134 0.069 0.4082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Plasmodium vivax vivapain-1 0.0134 0.069 0.4082
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0066 0.0342
Mycobacterium tuberculosis Probable lipase LipD 0.0113 0.0558 0.1286
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2984 1
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0054 0.019 0.3256
Brugia malayi Cathepsin L-like precursor 0.0295 0.169 0.2759
Entamoeba histolytica cysteine proteinase, putative 0.0295 0.169 1
Trypanosoma brucei prolyl oligopeptidase, putative 0.0054 0.019 0.0869
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0066 0.1172
Schistosoma mansoni hypothetical protein 0.0168 0.0903 0.1473
Echinococcus granulosus pyruvate kinase 0.0034 0.0066 0.0108
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0157 0.0256
Loa Loa (eye worm) hypothetical protein 0.01 0.0478 0.0781
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0295 0.169 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0295 0.169 0.2759
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0113 0.0558 0.0911
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0089 0.0145
Onchocerca volvulus Glucosylceramidase homolog 0.033 0.1909 1
Echinococcus multilocularis cathepsin b 0.101 0.6126 0.6126
Plasmodium falciparum glutathione reductase 0.0046 0.0142 0.0843
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0055 0.02 0.0326
Brugia malayi Thioredoxin reductase 0.0046 0.0142 0.0232
Schistosoma mansoni cathepsin B (C01 family) 0.009 0.0415 0.0677
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0558 0.0911
Onchocerca volvulus Cathepsin L homolog 0.0295 0.169 0.8852
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0508 0.1169
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0592 0.3535 0.577
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.069 0.3163
Schistosoma mansoni alpha-glucosidase 0.0135 0.0698 0.114
Giardia lamblia Cathepsin L precursor 0.009 0.0415 0.1901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Loa Loa (eye worm) ctsf protein 0.0295 0.169 0.2759
Brugia malayi cathepsin L-like precursor 0.0251 0.1415 0.231
Schistosoma mansoni hypothetical protein 0.0045 0.0136 0.0222
Echinococcus multilocularis pyruvate kinase 0.0027 0.0022 0.0022
Echinococcus granulosus sodium:glucose cotransporter 0.0037 0.0089 0.0145
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0002
Schistosoma mansoni inositol transporter 0.0037 0.0089 0.0145
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0089 0.0089
Echinococcus granulosus cysteine protease 0.0134 0.069 0.1126
Loa Loa (eye worm) hypothetical protein 0.0295 0.169 0.2759
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0426 0.0426
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0096 0.0451 0.2358
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Giardia lamblia Cysteine protease 0.009 0.0415 0.1901
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Giardia lamblia Dipeptidyl-peptidase I precursor 0.009 0.0415 0.1901
Giardia lamblia Cathepsin B precursor 0.009 0.0415 0.1901
Giardia lamblia Dipeptidyl-peptidase I precursor 0.009 0.0415 0.1901
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0834 0.0834
Trypanosoma brucei cysteine peptidase C (CPC) 0.0374 0.2181 1
Plasmodium vivax ataxin-2 like protein, putative 0.01 0.0478 0.2829
Brugia malayi glutathione reductase 0.0046 0.0142 0.0232
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0002
Mycobacterium ulcerans hypothetical protein 0.0113 0.0558 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Brugia malayi Papain family cysteine protease containing protein 0.009 0.0415 0.0677
Mycobacterium ulcerans lipase LipD 0.0113 0.0558 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Plasmodium falciparum cysteine proteinase falcipain 1 0.0134 0.069 0.4082
Giardia lamblia Hypothetical protein 0.009 0.0415 0.1901
Schistosoma mansoni inositol transporter 0.0037 0.0089 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0109 0.0533 0.0533
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.069 0.4082
Brugia malayi fibroinase precursor 0.009 0.0415 0.0677
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0113 0.0558 0.0911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.0136 0.0222
Schistosoma mansoni high-affinity choline transporter 0.0338 0.1954 0.3189
Echinococcus multilocularis pyruvate kinase 0.0034 0.0066 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Loa Loa (eye worm) fibroinase 0.0295 0.169 0.2759
Plasmodium falciparum serine repeat antigen 8 0.009 0.0415 0.2454
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0074 0.0249
Brugia malayi Papain family cysteine protease containing protein 0.009 0.0415 0.0677
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0451 0.0736
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0055 0.02 0.0917
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.1386 0.2262
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.02 0.067
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0295 0.169 0.169
Brugia malayi RNA, U transporter 1 0.0089 0.0408 0.0667
Plasmodium vivax unspecified product 0.0134 0.069 0.4082
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.009 0.0415 0.139
Loa Loa (eye worm) hypothetical protein 0.0338 0.1954 0.3189
Entamoeba histolytica cysteine protease, putative 0.0295 0.169 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0055 0.02 0.0326
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0135 0.0693 0.1131
Loa Loa (eye worm) hypothetical protein 0.0048 0.0157 0.0256
Toxoplasma gondii ABC1 family protein 0.0113 0.0558 0.2558
Loa Loa (eye worm) hypothetical protein 0.0078 0.0341 0.0557
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.0834 0.1362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0074 0.034
Toxoplasma gondii cathepsin CPL 0.0295 0.169 0.7748
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0076 0.0076
Leishmania major pyruvate kinase 0.0034 0.0066 0.0304
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0066 0.0151
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.009 0.0415 0.2454
Giardia lamblia Cathepsin L precursor 0.009 0.0415 0.1901
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0055 0.02 0.0917
Echinococcus granulosus cathepsin l cysteine peptidase 0.0295 0.169 0.2759
Onchocerca volvulus 0.0295 0.169 0.8852
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0558 0.1869
Trypanosoma cruzi major cysteine proteinase, putative 0.009 0.0415 0.0677
Schistosoma mansoni sodium/solute symporter 0.0037 0.0089 0.0145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0558 0.0911
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.009 0.0415 0.2454
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0247 0.0403
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0251 0.1415 0.231
Giardia lamblia Hypothetical protein 0.009 0.0415 0.1901
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0341 0.0557
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0135 0.0693 0.1131
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0066 0.0304
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Plasmodium falciparum serine repeat antigen 7 0.009 0.0415 0.2454
Loa Loa (eye worm) glutathione reductase 0.0046 0.0142 0.0232
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0142 0.0232
Toxoplasma gondii cathepsin CPC1 0.009 0.0415 0.1901
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0478 0.2829
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0134 0.069 0.1126
Trichomonas vaginalis penicillin-binding protein, putative 0.0113 0.0558 0.1869
Brugia malayi Papain family cysteine protease containing protein 0.0295 0.169 0.2759
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0003 0.0018
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0247 0.0403
Echinococcus multilocularis prolyl endopeptidase 0.0135 0.0693 0.0693
Giardia lamblia Cathepsin L precursor 0.009 0.0415 0.1901
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.02 0.1183
Plasmodium falciparum serine repeat antigen 5 0.009 0.0415 0.2454
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0037 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.0677
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.0834 0.0834
Echinococcus multilocularis geminin 0.0862 0.5208 0.5208
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.009 0.0415 0.139
Plasmodium vivax vivapain-2 0.0295 0.169 1
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.009 0.0415 0.2454
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.009 0.0415 0.0677
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2984 1
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0076 0.0125
Echinococcus multilocularis tumor protein p63 0.033 0.1904 0.1904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0415 0.139
Brugia malayi cathepsin Z-like cysteine proteinase 0.009 0.0415 0.0677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0415 0.139
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0508 0.1169
Entamoeba histolytica cysteine proteinase, putative 0.0295 0.169 1
Mycobacterium tuberculosis Conserved protein 0.0113 0.0558 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0415 0.139
Entamoeba histolytica hypothetical protein 0.009 0.0415 0.2454
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.009 0.0415 0.139
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0074 0.0249
Echinococcus multilocularis cysteine protease 0.0295 0.169 0.169
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0044 0.0133 0.0216
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.009 0.0415 0.2454
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0461 0.0752
Onchocerca volvulus 0.0048 0.0157 0.0818
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0113 0.0558 0.1286
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0054 0.019 0.0869
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.009 0.0415 0.139
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0015 0.0049
Loa Loa (eye worm) hypothetical protein 0.101 0.6126 1
Schistosoma mansoni cathepsin S (C01 family) 0.009 0.0415 0.0677
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0054 0.019 0.0309
Brugia malayi mbt repeat family protein 0.0096 0.0451 0.0736
Plasmodium vivax importin-beta 2, putative 0.0031 0.0051 0.0303
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0415 0.139
Loa Loa (eye worm) cysteine protease 0.0295 0.169 0.2759
Trypanosoma cruzi cruzipain precursor, putative 0.0295 0.169 0.2759
Toxoplasma gondii preprocathepsin c precursor, putative 0.009 0.0415 0.1901
Giardia lamblia Cathepsin L precursor 0.009 0.0415 0.1901
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0508 0.8747
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.009 0.0415 0.2454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Loa Loa (eye worm) mbt repeat family protein 0.0096 0.0451 0.0736
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0005
Echinococcus multilocularis high affinity choline transporter 1 0.0338 0.1954 0.1954
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0295 0.169 1
Mycobacterium tuberculosis Probable reductase 0.0105 0.0508 0.1169
Loa Loa (eye worm) hypothetical protein 0.0044 0.0133 0.0216
Loa Loa (eye worm) beta-lactamase 0.0113 0.0558 0.0911
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0341 0.0341
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0142 0.0843
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.069 0.4082
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0066 0.0108
Toxoplasma gondii exonuclease III APE 0.0055 0.02 0.0917
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0341 0.0557
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0388 0.2266 0.3698
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Loa Loa (eye worm) cathepsin B 0.0374 0.2181 0.356
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.009 0.0415 0.0677
Plasmodium vivax serine-repeat antigen (SERA), putative 0.009 0.0415 0.2454
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.058 0.1337
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Onchocerca volvulus 0.0295 0.169 0.8852
Onchocerca volvulus 0.0251 0.1415 0.741
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.009 0.0415 0.2454
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0066 0.0108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Trypanosoma cruzi cysteine protease, putative 0.0134 0.069 0.1126
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0051 0.0235
Trypanosoma brucei prolyl endopeptidase 0.0135 0.0693 0.3176
Echinococcus granulosus tumor protein p63 0.033 0.1904 0.3108
Leishmania major hypothetical protein, conserved 0.0113 0.0558 0.2558
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.0677
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.009 0.0415 0.2454
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0055 0.02 0.1183
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0415 0.139
Brugia malayi hypothetical protein 0.0065 0.0258 0.0421
Schistosoma mansoni pyruvate kinase 0.0034 0.0066 0.0108
Giardia lamblia Cathepsin L precursor 0.009 0.0415 0.1901
Entamoeba histolytica papain family cysteine protease domain containing protein 0.009 0.0415 0.2454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Toxoplasma gondii cathepsin B 0.0374 0.2181 1
Brugia malayi Cathepsin L-like precursor 0.0295 0.169 0.2759
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0109 0.0533 0.087
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Giardia lamblia Cysteine protease 0.009 0.0415 0.1901
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0415 0.139
Loa Loa (eye worm) hypothetical protein 0.0032 0.0057 0.0093
Schistosoma mansoni hypothetical protein 0.0862 0.5208 0.8502
Entamoeba histolytica cysteine proteinase 1, putative 0.0134 0.069 0.4082
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2984 1
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.009 0.0415 0.1901
Giardia lamblia Cysteine protease 0.009 0.0415 0.1901
Mycobacterium tuberculosis Conserved protein 0.0113 0.0558 0.1286
Plasmodium falciparum cysteine proteinase falcipain 3 0.0295 0.169 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0461 0.0461
Echinococcus granulosus cathepsin b 0.101 0.6126 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0089 0.0145
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0142 0.0326
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.2019 0.6767
Brugia malayi beta-lactamase family protein 0.0113 0.0558 0.0911
Onchocerca volvulus 0.0295 0.169 0.8852
Echinococcus granulosus prolyl endopeptidase 0.0135 0.0693 0.1131
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0504 0.2984 0.4871
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0461 0.0752
Echinococcus multilocularis cathepsin L 0.009 0.0415 0.0415
Trypanosoma cruzi prolyl endopeptidase 0.0135 0.0693 0.1131
Brugia malayi Cathepsin L-like precursor 0.0295 0.169 0.2759
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.009 0.0415 0.2454
Plasmodium vivax vivapain-2 0.0295 0.169 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0461 0.0461
Leishmania major hypothetical protein, conserved 0.01 0.0478 0.2192
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0055 0.02 0.3572
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0015 0.0049
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0066 0.0392
Plasmodium falciparum serine repeat antigen 1 0.009 0.0415 0.2454
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0113 0.0558 0.1286
Echinococcus granulosus cathepsin l1 0.0251 0.1415 0.231
Plasmodium falciparum serine repeat antigen 4 0.009 0.0415 0.2454
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0142 0.0232
Brugia malayi MH2 domain containing protein 0.0246 0.1386 0.2262
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0558 0.1869
Onchocerca volvulus 0.0037 0.0089 0.0459
Giardia lamblia Cathepsin B precursor 0.0374 0.2181 1
Trypanosoma brucei PAB1-binding protein , putative 0.01 0.0478 0.2192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0341 0.0341
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.0834 0.1362
Mycobacterium tuberculosis Probable lipase LipE 0.0113 0.0558 0.1286
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.1386 0.2262
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.0136 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2984 1
Giardia lamblia Cathepsin B precursor 0.009 0.0415 0.1901
Mycobacterium leprae conserved hypothetical protein 0.0113 0.0558 0.9616
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0134 0.069 0.1126
Loa Loa (eye worm) hypothetical protein 0.0168 0.0903 0.1473
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.009 0.0415 0.2454
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Onchocerca volvulus 0.0295 0.169 0.8852
Loa Loa (eye worm) hypothetical protein 0.0113 0.0558 0.0911
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.009 0.0415 0.0677
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.069 0.4082
Plasmodium falciparum serine repeat antigen 2 0.009 0.0415 0.2454
Mycobacterium tuberculosis Probable peptidase 0.0054 0.019 0.0435
Loa Loa (eye worm) hypothetical protein 0.0109 0.0533 0.087
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0247 0.0247
Onchocerca volvulus 0.0295 0.169 0.8852
Loa Loa (eye worm) hypothetical protein 0.0113 0.0558 0.0911
Onchocerca volvulus 0.0113 0.0558 0.2919
Schistosoma mansoni cathepsin s 0.0044 0.0133 0.0216
Brugia malayi Cathepsin L-like cysteine proteinase 0.0251 0.1415 0.231
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0055 0.02 0.0326
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0374 0.2181 0.356
Trypanosoma cruzi oligopeptidase b 0.0054 0.019 0.0309
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0113 0.0558 0.0911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.069 0.2312
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0426 0.0696
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0089 0.0145
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0341 0.0557
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0066 0.0342
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Loa Loa (eye worm) MBCTL1 0.0109 0.0533 0.087
Schistosoma mansoni sex comb on midleg homolog 0.0096 0.0451 0.0736
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.0235
Onchocerca volvulus Cathepsin L homolog 0.0295 0.169 0.8852
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.009 0.0415 0.2454
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.169 0.2759
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0001 0.0006
Onchocerca volvulus Cathepsin F homolog 0.0295 0.169 0.8852
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.101 0.6126 1
Plasmodium vivax vivapain-3 0.0134 0.069 0.4082
Leishmania major importin beta-1 subunit, putative 0.0025 0.0015 0.0067
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0074 0.0121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.101 0.6126 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.009 0.0415 0.2454
Trypanosoma brucei trypanothione reductase 0.0046 0.0142 0.0653
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0066 0.0342
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0251 0.1415 0.4741
Onchocerca volvulus 0.0096 0.0451 0.2358
Plasmodium falciparum ataxin-2 like protein, putative 0.01 0.0478 0.2829
Loa Loa (eye worm) hypothetical protein 0.0095 0.0446 0.0728
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0066 0.0108
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.058 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.0834 0.1362
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0134 0.069 0.1126
Toxoplasma gondii prolyl endopeptidase 0.0135 0.0693 0.3176
Loa Loa (eye worm) hypothetical protein 0.0246 0.1386 0.2263
Echinococcus granulosus SAM and MBT domain containing protein 0.0096 0.0451 0.0736
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.009 0.0415 0.0677
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0113 0.0558 0.1286
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.012 0.0605 0.1395
Brugia malayi exodeoxyribonuclease III family protein 0.0055 0.02 0.0326
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.169 0.2759
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0066 0.0108
Brugia malayi cathepsin L-like cysteine proteinase 0.009 0.0415 0.0677
Mycobacterium ulcerans esterase/lipase LipP 0.0113 0.0558 1
Giardia lamblia Encystation-specific protease 0.009 0.0415 0.1901
Brugia malayi cathepsin Z-like cysteine proteinase 0.009 0.0415 0.0677
Trichomonas vaginalis glucosylceramidase, putative 0.033 0.1909 0.6397
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Schistosoma mansoni importin beta-1 0.0031 0.0051 0.0084
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0374 0.2181 1
Entamoeba histolytica cysteine protease, putative 0.009 0.0415 0.2454
Trypanosoma cruzi cysteine peptidase, putative 0.0044 0.0133 0.0216
Schistosoma mansoni pyruvate kinase 0.0034 0.0066 0.0108
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0037 0.0089 0.0089
Echinococcus multilocularis SAM and MBT domain containing protein 0.0096 0.0451 0.0451
Entamoeba histolytica papain family cysteine protease domain containing protein 0.009 0.0415 0.2454
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0066 0.0108
Onchocerca volvulus Cathepsin L homolog 0.009 0.0415 0.2168
Echinococcus granulosus cathepsin b 0.101 0.6126 1
Schistosoma mansoni myelin transcription factor 1 myt1 0.0109 0.0533 0.087
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.0677
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0461 0.0752
Plasmodium falciparum pyruvate kinase 0.0034 0.0066 0.0392
Plasmodium falciparum importin beta, putative 0.0031 0.0051 0.0303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0133 0.0216
Echinococcus granulosus cathepsin L cysteine protease 0.0134 0.069 0.1126
Loa Loa (eye worm) hypothetical protein 0.0113 0.0558 0.0911
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0415 0.139
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0044 0.0133 0.0216
Loa Loa (eye worm) hypothetical protein 0.0113 0.0558 0.0911
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.009 0.0415 0.0677
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0508 0.1169
Treponema pallidum exodeoxyribonuclease (exoA) 0.0055 0.02 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.0295 0.169 0.2759
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0341 0.0557
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0415 0.139
Echinococcus multilocularis solute carrier family 5 0.0037 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0295 0.169 0.2759
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0066 0.0304
Brugia malayi Cathepsin L-like precursor 0.0295 0.169 0.2759
Brugia malayi GH02984p 0.0338 0.1954 0.3189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Schistosoma mansoni alpha-glucosidase 0.0135 0.0698 0.114
Mycobacterium tuberculosis Probable hydrolase 0.0113 0.0558 0.1286
Trichomonas vaginalis glucosylceramidase, putative 0.0348 0.2019 0.6767
Trypanosoma cruzi cysteine proteinase, putative 0.0134 0.069 0.1126
Brugia malayi Papain family cysteine protease containing protein 0.0134 0.069 0.1126
Mycobacterium leprae Probable lipase LipE 0.0113 0.0558 0.9616
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0074 0.0121
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Brugia malayi Cathepsin L-like precursor 0.0251 0.1415 0.231
Schistosoma mansoni hypothetical protein 0.0078 0.0341 0.0557
Schistosoma mansoni hypothetical protein 0.0862 0.5208 0.8502
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0374 0.2181 0.7309
Plasmodium falciparum serine repeat antigen 9 0.009 0.0415 0.2454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0054 0.019 0.0869
Chlamydia trachomatis pyruvate kinase 0.0034 0.0066 0.5
Mycobacterium tuberculosis Probable esterase LipL 0.0113 0.0558 0.1286
Brugia malayi cathepsin F-like cysteine proteinase 0.009 0.0415 0.0677
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Giardia lamblia Dipeptidyl-peptidase I precursor 0.009 0.0415 0.1901
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Onchocerca volvulus 0.0295 0.169 0.8852
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0015 0.0049
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.058 0.1337
Trypanosoma cruzi cruzipain precursor, putative 0.0044 0.0133 0.0216
Brugia malayi Calcitonin receptor-like protein seb-1 0.0246 0.1386 0.2263
Entamoeba histolytica cysteine protease, putative 0.009 0.0415 0.2454
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.069 0.3163
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0066 0.0304
Echinococcus multilocularis cathepsin b 0.101 0.6126 0.6126
Leishmania major oligopeptidase b 0.0054 0.019 0.0869
Echinococcus granulosus polycomb protein SCMH1 0.0096 0.0451 0.0736
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.101 0.6126 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0109 0.0533 0.087
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0074 0.0249
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0446 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Mycobacterium tuberculosis Conserved protein 0.0113 0.0558 0.1286
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0005
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0247 0.0247
Plasmodium vivax serine-repeat antigen (SERA) 0.009 0.0415 0.2454
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0113 0.0558 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0295 0.169 0.169
Echinococcus granulosus pyruvate kinase 0.0034 0.0066 0.0108
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0001 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0055 0.02 0.1183
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0074 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2984 1
Entamoeba histolytica hypothetical protein 0.0025 0.0015 0.0086
Trypanosoma cruzi cysteine proteinase, putative 0.0134 0.069 0.1126
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0374 0.2181 0.356
Schistosoma mansoni transient receptor potential channel 0.0063 0.0247 0.0403
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0446 0.0728
Entamoeba histolytica cysteine proteinase, putative 0.0251 0.1415 0.8372
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0246 0.1386 0.2263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0461 0.0752
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0251 0.1415 0.4741
Leishmania major trypanothione reductase 0.0046 0.0142 0.0653
Loa Loa (eye worm) hypothetical protein 0.006 0.0227 0.0371
Brugia malayi cathepsin L precursor 0.009 0.0415 0.0677
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.009 0.0415 0.139
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0142 0.0142
Onchocerca volvulus Prolyl endopeptidase homolog 0.0135 0.0693 0.3626
Plasmodium falciparum serine repeat antigen 6 0.009 0.0415 0.2454
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0134 0.069 0.1126
Brugia malayi beta-lactamase 0.0113 0.0558 0.0911
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.009 0.0415 0.0677
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0461 0.0752
Schistosoma mansoni hypothetical protein 0.0078 0.0341 0.0557
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0295 0.169 0.169
Echinococcus multilocularis cathepsin L 0.0134 0.069 0.069
Echinococcus granulosus cathepsin L cysteine proteinase 0.0295 0.169 0.2759
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.009 0.0415 0.0677
Giardia lamblia Cathepsin B precursor 0.009 0.0415 0.1901
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0295 0.169 0.5663
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.101 0.6126 1
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0558 0.0911
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Loa Loa (eye worm) hypothetical protein 0.0113 0.0558 0.0911
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0074 0.0249
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0066 0.0222
Echinococcus granulosus high affinity choline transporter 1 0.0338 0.1954 0.3189
Leishmania major cathepsin L-like protease 0.0295 0.169 0.7748
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.009 0.0415 0.0677
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0461 0.0752
Trichomonas vaginalis glucosylceramidase, putative 0.0504 0.2984 1
Entamoeba histolytica cysteine protease, putative 0.0134 0.069 0.4082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.009 0.0415 0.0677
Echinococcus multilocularis cysteine protease 0.0295 0.169 0.169
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.009 0.0415 0.139
Plasmodium falciparum thioredoxin reductase 0.0046 0.0142 0.0843
Entamoeba histolytica cysteine protease, putative 0.009 0.0415 0.2454
Trypanosoma brucei glucosidase, putative 0.0035 0.0074 0.034
Loa Loa (eye worm) hypothetical protein 0.0044 0.0133 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.009 0.0415 0.139
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0446 0.0728
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.009 0.0415 0.139
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0295 0.169 0.5663
Trichomonas vaginalis ap endonuclease, putative 0.0055 0.02 0.067
Trypanosoma cruzi oligopeptidase b 0.0054 0.019 0.0309
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0074 0.0249
Echinococcus multilocularis pyruvate kinase 0.0034 0.0066 0.0066
Echinococcus granulosus cathepsin L 0.009 0.0415 0.0677
Giardia lamblia Cathepsin B precursor 0.0374 0.2181 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0142 0.0232
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0066 0.0222
Schistosoma mansoni cathepsin C 0.009 0.0415 0.0677
Giardia lamblia Cathepsin B precursor 0.009 0.0415 0.1901
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.009 0.0415 0.2454
Echinococcus granulosus importin subunit beta 1 0.0031 0.0051 0.0084
Loa Loa (eye worm) hypothetical protein 0.0251 0.1415 0.231
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0096 0.0451 0.0736
Schistosoma mansoni transient receptor potential channel 0.0095 0.0446 0.0728
Echinococcus granulosus solute carrier family 5 0.0037 0.0089 0.0145
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0295 0.169 0.7748
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0051 0.0235
Echinococcus granulosus sodium:glucose cotransporter 2 0.0037 0.0089 0.0145
Echinococcus granulosus beta LACTamase domain containing family member 0.0113 0.0558 0.0911
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0113 0.0558 0.0911
Schistosoma mansoni hypothetical protein 0.0333 0.1926 0.3144
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.009 0.0415 0.139
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0109 0.0533 0.087
Schistosoma mansoni hypothetical protein 0.0078 0.0341 0.0557
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0558 0.2558
Brugia malayi beta-lactamase family protein 0.0113 0.0558 0.0911
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0478 0.0781
Entamoeba histolytica cysteine protease, putative 0.009 0.0415 0.2454
Entamoeba histolytica cysteine proteinase, putative 0.0134 0.069 0.4082
Loa Loa (eye worm) papain family cysteine protease containing protein 0.009 0.0415 0.0677
Mycobacterium ulcerans beta-lactamase 0.0113 0.0558 1
Plasmodium vivax unspecified product 0.009 0.0415 0.2454
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0415 0.139
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0074 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.01 0.0478 0.2192
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0074 0.0439
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0055 0.02 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0341 0.0557
Brugia malayi mbt repeat family protein 0.0096 0.0451 0.0736
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0074 0.0439
Onchocerca volvulus 0.0113 0.0558 0.2919
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0074 0.034
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.009 0.0415 0.0677
Trichomonas vaginalis esterase, putative 0.0113 0.0558 0.1869
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0074 0.0249
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.0677
Brugia malayi Importin beta-1 subunit 0.0031 0.0051 0.0084
Giardia lamblia Cathepsin L precursor 0.009 0.0415 0.1901
Echinococcus granulosus sodium:myo inositol cotransporter 0.0037 0.0089 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.009 0.0415 0.139
Brugia malayi Cathepsin L-like precursor 0.0295 0.169 0.2759
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0055 0.02 0.02
Onchocerca volvulus 0.009 0.0415 0.2168
Schistosoma mansoni hypothetical protein 0.0078 0.0341 0.0557
Giardia lamblia Cathepsin B precursor 0.009 0.0415 0.1901
Trypanosoma cruzi PAB1-binding protein , putative 0.01 0.0478 0.0781
Onchocerca volvulus 0.0091 0.0422 0.2209
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0001 0.0006
Leishmania major pyruvate kinase 0.0034 0.0066 0.0304
Brugia malayi hypothetical protein 0.01 0.0478 0.0781
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0504 0.2984 0.4871
Brugia malayi cathepsin F-like cysteine proteinase 0.0044 0.0133 0.0216
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0089 0.0406
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0066 0.1127
Brugia malayi Cathepsin L-like precursor 0.0251 0.1415 0.231
Loa Loa (eye worm) hypothetical protein 0.0135 0.0693 0.1131
Schistosoma mansoni alpha glucosidase 0.0035 0.0074 0.0121
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0051 0.0051
Echinococcus granulosus cathepsin L 0.0134 0.069 0.1126
Loa Loa (eye worm) hypothetical protein 0.0096 0.0451 0.0736
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0074 0.0249
Onchocerca volvulus 0.0113 0.0558 0.2919
Echinococcus granulosus GPCR family 2 0.0078 0.0341 0.0557
Toxoplasma gondii thioredoxin reductase 0.0046 0.0142 0.0653
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.0903 0.1473
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0134 0.069 0.2312
Plasmodium vivax unspecified product 0.0044 0.0133 0.0784
Brugia malayi cahepsin L-like non-peptiedase homolog 0.009 0.0415 0.0677
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.009 0.0415 0.0677
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0066 0.0108
Giardia lamblia Cysteine protease 0.009 0.0415 0.1901
Loa Loa (eye worm) hypothetical protein 0.0023 0.0001 0.0002
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0066 0.0108
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.069 0.1126
Trypanosoma cruzi cysteine peptidase, putative 0.0295 0.169 0.2759
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0135 0.0693 0.3176
Plasmodium vivax hypothetical protein, conserved 0.0113 0.0558 0.3301
Brugia malayi Cathepsin L-like precursor 0.0044 0.0133 0.0216
Giardia lamblia Pyruvate kinase 0.0034 0.0066 0.0304
Entamoeba histolytica cysteine protease, putative 0.009 0.0415 0.2454
Brugia malayi cathepsin B-like cysteine proteinase 0.101 0.6126 1
Trypanosoma cruzi major cysteine proteinase, putative 0.009 0.0415 0.0677
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0388 0.2266 0.2266
Echinococcus granulosus snurportin 1 0.0333 0.1926 0.3144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0508 0.1169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0076 0.0125
Brugia malayi Papain family cysteine protease containing protein 0.009 0.0415 0.0677
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0295 0.169 0.5663
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0003 0.0005
Trichomonas vaginalis D-aminoacylase, putative 0.0113 0.0558 0.1869
Schistosoma mansoni cathepsin F (C01 family) 0.0295 0.169 0.2759
Echinococcus multilocularis polycomb protein SCMH1 0.0096 0.0451 0.0451
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0055 0.02 0.0917
Plasmodium vivax glutathione reductase, putative 0.0046 0.0142 0.0843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.1926 0.3144
Schistosoma mansoni ap endonuclease 0.0055 0.02 0.0326
Brugia malayi prolyl oligopeptidase family protein 0.0135 0.0693 0.1131
Echinococcus multilocularis GPCR, family 2 0.0078 0.0341 0.0341
Loa Loa (eye worm) hypothetical protein 0.0251 0.1415 0.231
Echinococcus granulosus cathepsin l1 0.0295 0.169 0.2759
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0001 0.0002
Schistosoma mansoni transient receptor potential channel 0.0063 0.0247 0.0403
Leishmania major cysteine peptidase A (CPA) 0.0295 0.169 0.7748
Echinococcus multilocularis histone acetyltransferase MYST2 0.0109 0.0533 0.0533
Giardia lamblia Cathepsin L-like protease 0.009 0.0415 0.1901
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0055 0.02 0.0459
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0074 0.0249
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0076 0.0125
Loa Loa (eye worm) hypothetical protein 0.009 0.0415 0.0677
Loa Loa (eye worm) hypothetical protein 0.0251 0.1415 0.231

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = -6.2 Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor in rat brain cortical membranes using radioligand [3H]-quipazine ChEMBL. 8410977

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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