Detailed information for compound 105067

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.266 | Formula: C11H19N4O6P
  • H donors: 3 H acceptors: 7 LogP: -2.39 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)CCCC(=O)NC(CP(=O)(O)O)Cn1cncn1
  • InChi: 1S/C11H19N4O6P/c1-21-11(17)4-2-3-10(16)14-9(6-22(18,19)20)5-15-8-12-7-13-15/h7-9H,2-6H2,1H3,(H,14,16)(H2,18,19,20)
  • InChiKey: AOGATPYMVMBHGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cryptococcus neoformans var. neoformans B-3501A Imidazoleglycerol-phosphate dehydratase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
Candida albicans Imidazole glycerol phosphate dehydratase Get druggable targets OG5_129258 All targets in OG5_129258
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Nanchung homolog Imidazoleglycerol-phosphate dehydratase   202 aa 162 aa 19.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.0195 0.0195
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.003 0.05
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.004 0.0074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0162 0.0877 0.2749
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Entamoeba histolytica hypothetical protein 0.0071 0.035 1
Brugia malayi beta-lactamase family protein 0.0047 0.0206 0.0386
Mycobacterium ulcerans esterase/lipase LipP 0.0047 0.0206 0.0456
Leishmania major hypothetical protein, conserved 0.0017 0.003 0.05
Loa Loa (eye worm) hypothetical protein 0.0067 0.0327 0.0612
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0134 0.0712 0.2233
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0016 0.0027 0.005
Echinococcus granulosus beta LACTamase domain containing family member 0.0047 0.0206 0.0647
Echinococcus multilocularis musashi 0.0045 0.0199 0.0199
Onchocerca volvulus 0.1057 0.6088 1
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.004 0.0027
Echinococcus granulosus histone lysine methyltransferase setb 0.0162 0.0877 0.2749
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.0195 0.0195
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0079 0.0128
Brugia malayi Bromodomain containing protein 0.0063 0.0303 0.0568
Schistosoma mansoni ap endonuclease 0.0016 0.0029 0.0091
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0018 0.004 0.0124
Schistosoma mansoni lamin 0.0045 0.0199 0.0623
Echinococcus multilocularis zinc finger protein 0.0034 0.0132 0.0132
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Entamoeba histolytica hypothetical protein 0.0038 0.0158 0.4162
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0051 0.0232 0.0232
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0016 0.0027 0.0084
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0065 0.0311 0.0311
Entamoeba histolytica acyl-CoA synthetase, putative 0.0033 0.0128 0.3254
Echinococcus granulosus tumor protein p63 0.0224 0.1237 0.3879
Echinococcus multilocularis GPCR, family 2 0.0075 0.0372 0.0372
Echinococcus granulosus cpg binding protein 0.0033 0.0123 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0352 0.1103
Loa Loa (eye worm) hypothetical protein 0.0034 0.0131 0.0246
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0206 0.0305
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0075 0.0372 0.0372
Schistosoma mansoni cpg binding protein 0.0033 0.0123 0.0386
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0029 0.0054
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0038 0.0158 0.1883
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0386
Echinococcus multilocularis lysine specific demethylase 5A 0.0024 0.0073 0.0073
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0128 0.0239
Brugia malayi mbt repeat family protein 0.0045 0.0195 0.0366
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Plasmodium vivax importin-beta 2, putative 0.0019 0.0041 0.018
Entamoeba histolytica hypothetical protein 0.0071 0.035 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0016 0.0027 0.0084
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0002 0.0007
Schistosoma mansoni zinc finger protein 0.0025 0.0081 0.0255
Echinococcus granulosus snurportin 1 0.0198 0.1084 0.3399
Brugia malayi CXXC zinc finger family protein 0.0028 0.0095 0.0179
Loa Loa (eye worm) hypothetical protein 0.0064 0.0304 0.0569
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0239
Schistosoma mansoni RAR-like nuclear receptor 0.0016 0.0027 0.0084
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0033 0.0128 0.0255
Schistosoma mansoni hypothetical protein 0.002 0.0049 0.0153
Echinococcus multilocularis lamin 0.0045 0.0199 0.0199
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Loa Loa (eye worm) transcription factor SMAD2 0.0167 0.0908 0.17
Schistosoma mansoni hypothetical protein 0.0559 0.319 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0039 0.016 0.016
Brugia malayi photoreceptor-specific nuclear receptor 0.0016 0.0027 0.005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0027 0.0084
Brugia malayi steroid hormone receptor 0.0016 0.0027 0.005
Plasmodium vivax ataxin-2 like protein, putative 0.0017 0.003 0.0018
Toxoplasma gondii ABC1 family protein 0.0047 0.0206 0.2594
Loa Loa (eye worm) hypothetical protein 0.0072 0.0354 0.0664
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0016 0.0027 0.0084
Mycobacterium tuberculosis Probable lipase LipD 0.0047 0.0206 0.0456
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0018 0.004 0.0031
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0038 0.0158 1
Brugia malayi beta-lactamase family protein 0.0047 0.0206 0.0386
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0038 0.0158 0.0331
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0386
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0195 0.0613
Mycobacterium ulcerans hypothetical protein 0.0047 0.0206 0.0456
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.1289 0.2413
Echinococcus granulosus dna polymerase kappa 0.0018 0.004 0.0124
Loa Loa (eye worm) TAR-binding protein 0.0137 0.0733 0.1373
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0016 0.0027 0.005
Echinococcus multilocularis G protein coupled receptor 139 0.0084 0.042 0.042
Leishmania major hypothetical protein, conserved 0.0025 0.0081 0.3253
Mycobacterium tuberculosis Conserved protein 0.0047 0.0206 0.0456
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0038 0.0158 1
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0049 0.029
Loa Loa (eye worm) hypothetical protein 0.0045 0.0194 0.0363
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0158 0.0169
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0038 0.0158 0.1883
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0134 0.0712 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0051 0.0232 0.0434
Loa Loa (eye worm) RNA binding protein 0.0137 0.0733 0.1373
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0027 0.005
Brugia malayi MH2 domain containing protein 0.0167 0.0908 0.17
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0386
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0018 0.004 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0129 0.0686 0.1096
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0238 0.1321 0.2472
Echinococcus multilocularis geminin 0.0559 0.319 0.319
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0101 0.0519 0.1627
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0012 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0016 0.0027 0.005
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.0195 0.0312
Loa Loa (eye worm) hypothetical protein 0.0075 0.0372 0.0697
Onchocerca volvulus 0.0047 0.0206 0.033
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0029 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.003 0.0093
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0305 0.0957
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Brugia malayi ImpB/MucB/SamB family protein 0.0018 0.004 0.0074
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0075 0.0372 0.1168
Loa Loa (eye worm) hypothetical protein 0.0238 0.1321 0.2472
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0027 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1022 0.1649
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0101 0.0316
Mycobacterium leprae Probable lipase LipE 0.0047 0.0206 0.0443
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0016 0.0027 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0071 0.0108
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.018 0.0985 0.0985
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0038 0.0158 0.0331
Echinococcus granulosus methyl CpG binding domain protein 2 0.0028 0.0098 0.0308
Loa Loa (eye worm) hypothetical protein 0.0045 0.0199 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0206 1
Onchocerca volvulus 0.0047 0.0206 0.033
Schistosoma mansoni hypothetical protein 0.0071 0.035 0.1096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0027 0.005
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.0195 0.0613
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0029 0.1123
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0386
Plasmodium vivax SET domain protein, putative 0.0134 0.0712 1
Trichomonas vaginalis set domain proteins, putative 0.1057 0.6088 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.004 0.1
Loa Loa (eye worm) hypothetical protein 0.0162 0.0877 0.1642
Schistosoma mansoni jumonji/arid domain-containing protein 0.0029 0.0101 0.0316
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0012 0.0012
Echinococcus granulosus zinc finger protein 0.0034 0.0132 0.0413
Onchocerca volvulus 0.0137 0.0731 0.1192
Schistosoma mansoni cellular tumor antigen P53 0.0033 0.0124 0.039
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0095 0.0179
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0029 0.0436
Mycobacterium leprae Probable imidazole glycerol-phosphate dehydratase HisB 0.0337 0.1896 1
Brugia malayi PHD-finger family protein 0.0043 0.0183 0.0343
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0206 1
Loa Loa (eye worm) bromodomain containing protein 0.0029 0.0104 0.0195
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0047 0.0206 0.0386
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.0195 0.0366
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0041 0.174
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0071 0.0108
Schistosoma mansoni hypothetical protein 0.0559 0.319 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0041 0.0077
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0029 0.0436
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0016 0.0027 0.0027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0101 0.0519 0.0519
Schistosoma mansoni intermediate filament proteins 0.0045 0.0199 0.0623
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0291 0.384
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0016 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0299 0.1676 0.424
Trypanosoma cruzi ISWI complex protein 0.0025 0.0081 0.3253
Schistosoma mansoni hypothetical protein 0.0075 0.0372 0.1168
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0033 0.0128 0.0255
Brugia malayi latrophilin 2 splice variant baaae 0.0163 0.0882 0.1651
Loa Loa (eye worm) latrophilin receptor protein 2 0.0075 0.0372 0.0697
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0238 0.1321 0.2472
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0072 0.0352 0.0659
Mycobacterium tuberculosis Conserved protein 0.0047 0.0206 0.0456
Echinococcus multilocularis L aminoadipate semialdehyde 0.0137 0.0731 0.0731
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0137 0.0731 0.2291
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0016 0.0027 0.005
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0239
Giardia lamblia DINP protein human, muc B family 0.0018 0.004 0.5282
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0137 0.0731 0.1368
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0071 0.0108
Brugia malayi beta-lactamase 0.0047 0.0206 0.0386
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0101 0.0189
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0018 0.004 0.004
Brugia malayi PHD-finger family protein 0.002 0.0049 0.0091
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0016 0.0027 0.005
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0352 0.0352
Brugia malayi jmjC domain containing protein 0.0065 0.0311 0.0582
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0075 0.0372 0.0697
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0027 0.0084
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.0195 0.0613
Echinococcus multilocularis peregrin 0.0024 0.0072 0.0072
Brugia malayi Importin beta-1 subunit 0.0019 0.0041 0.0077
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.0195 0.0613
Brugia malayi jmjC domain containing protein 0.0029 0.0101 0.0189
Loa Loa (eye worm) hypothetical protein 0.0117 0.0616 0.1154
Trypanosoma brucei PAB1-binding protein , putative 0.0017 0.003 0.1183
Onchocerca volvulus 0.0045 0.0199 0.0317
Schistosoma mansoni neuropeptide receptor 0.0084 0.042 0.1318
Onchocerca volvulus Bile acid receptor homolog 0.0016 0.0027 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0016 0.0027 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0007
Brugia malayi nuclear hormone receptor 0.0016 0.0027 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1022 0.1649
Echinococcus multilocularis PHD finger protein rhinoceros 0.002 0.0049 0.0049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0928 0.5341 1
Echinococcus granulosus lamin dm0 0.0045 0.0199 0.0623
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0128 0.0239
Echinococcus multilocularis importin subunit beta 1 0.0019 0.0041 0.0041
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.004 0.1647
Brugia malayi AMP-binding enzyme family protein 0.0033 0.0128 0.0239
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0128 0.0255
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.0733 0.1373
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0162 0.0877 0.0877
Loa Loa (eye worm) hypothetical protein 0.0018 0.004 0.0074
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0187 0.1022 0.1913
Schistosoma mansoni cpg binding protein 0.0033 0.0123 0.0386
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0148
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0195 0.0613
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Brugia malayi intermediate filament protein 0.0045 0.0199 0.0372
Loa Loa (eye worm) hypothetical protein 0.0137 0.0731 0.1368
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0027 0.0084
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0071 0.0108
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0115
Loa Loa (eye worm) hypothetical protein 0.0163 0.0882 0.1651
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1022 0.1649
Onchocerca volvulus 0.0016 0.0027 0.0035
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2237 0.2237
Schistosoma mansoni hypothetical protein 0.0075 0.0372 0.1168
Schistosoma mansoni bromodomain containing protein 0.0106 0.0554 0.1736
Brugia malayi Steroid receptor seven-up type 2 0.0016 0.0027 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Echinococcus granulosus histone acetyltransferase MYST2 0.0051 0.0232 0.0726
Entamoeba histolytica hypothetical protein 0.0071 0.035 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0018 0.004 0.1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0057 0.0106
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0016 0.0027 0.0084
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.003 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0016 0.0027 0.005
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0733 0.2298
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0027 0.005
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.004 0.1647
Echinococcus granulosus intermediate filament protein 0.0045 0.0199 0.0623
Echinococcus granulosus neuropeptide receptor 0.0084 0.042 0.1318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.004 0.1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0016 0.0027 0.005
Brugia malayi Pre-SET motif family protein 0.0928 0.5341 1
Loa Loa (eye worm) intermediate filament protein 0.0045 0.0199 0.0372
Schistosoma mansoni retinoic acid receptor RXR 0.0016 0.0027 0.0084
Brugia malayi ecdysteroid receptor 0.0016 0.0027 0.005
Mycobacterium ulcerans DNA polymerase IV 0.0018 0.004 0.0027
Schistosoma mansoni methyl-cpg binding protein mbd 0.0028 0.0098 0.0308
Brugia malayi mbt repeat family protein 0.0045 0.0195 0.0366
Mycobacterium tuberculosis Probable imidazole glycerol-phosphate dehydratase HisB 0.0683 0.3913 1
Toxoplasma gondii HEAT repeat-containing protein 0.0019 0.0041 0.018
Echinococcus granulosus geminin 0.0559 0.319 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0065 0.0311 0.0975
Echinococcus granulosus importin subunit beta 1 0.0019 0.0041 0.013
Toxoplasma gondii PHD-finger domain-containing protein 0.002 0.0049 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.035 0.1096
Plasmodium falciparum ataxin-2 like protein, putative 0.0017 0.003 0.0093
Onchocerca volvulus 0.0033 0.0124 0.0195
Mycobacterium tuberculosis Conserved protein 0.0047 0.0206 0.0456
Echinococcus multilocularis FTZ F1 alpha 0.0016 0.0027 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0352 0.1103
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0022 0.0061 0.0061
Echinococcus granulosus dna polymerase eta 0.0018 0.004 0.0124
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0016 0.0027 0.0084
Brugia malayi RNA binding protein 0.0137 0.0733 0.1373
Echinococcus multilocularis ecdysone induced protein 78C 0.0016 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1022 0.1649
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0016 0.0027 0.0084
Mycobacterium tuberculosis Probable lipase LipE 0.0047 0.0206 0.0456
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.028 0.0879
Schistosoma mansoni hypothetical protein 0.0198 0.1084 0.3399
Schistosoma mansoni ap endonuclease 0.0016 0.0029 0.0091
Echinococcus multilocularis lamin dm0 0.0045 0.0199 0.0199
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0075 0.0372 0.0372
Brugia malayi follicle stimulating hormone receptor 0.0233 0.1289 0.2413
Leishmania major 4-coumarate:coa ligase-like protein 0.0033 0.0128 0.5771
Schistosoma mansoni hypothetical protein 0.0075 0.0372 0.1168
Brugia malayi Intermediate filament tail domain containing protein 0.0045 0.0199 0.0372
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0027 0.0084
Brugia malayi TAR-binding protein 0.0137 0.0733 0.1373
Brugia malayi Calcitonin receptor-like protein seb-1 0.0238 0.1321 0.2472
Schistosoma mansoni methyl-cpg binding protein mbd 0.0028 0.0098 0.0308
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0075 0.0372 0.1168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0027 0.005
Schistosoma mansoni importin beta-1 0.0019 0.0041 0.013
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0733 0.2298
Schistosoma mansoni zinc finger protein 0.0034 0.0132 0.0413
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.004 0.0125
Trypanosoma brucei ISWI complex protein 0.0025 0.0081 0.3738
Trypanosoma cruzi ISWI complex protein 0.0025 0.0081 0.3253
Echinococcus granulosus endonuclease exonuclease phosphatase 0.018 0.0985 0.3087
Giardia lamblia PHD finger protein 15 0.002 0.0049 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0016 0.0027 0.005
Plasmodium vivax hypothetical protein, conserved 0.002 0.0049 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.0018 0.004 0.1647
Plasmodium falciparum acyl-CoA synthetase 0.0025 0.0079 0.3864
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0041 0.174
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0128 0.0255
Onchocerca volvulus Alhambra homolog 0.002 0.0049 0.0071
Mycobacterium ulcerans beta-lactamase 0.0047 0.0206 0.0456
Echinococcus multilocularis beta LACTamase domain containing family member 0.0047 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0277 0.1544 0.4842
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0047 0.0206 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0016 0.0027 0.005
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0012 0.0038
Onchocerca volvulus 0.0045 0.0199 0.0317
Schistosoma mansoni hypothetical protein 0.0034 0.0133 0.0416
Trichomonas vaginalis glucosylceramidase, putative 0.0129 0.0686 0.1096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0016 0.0027 0.005
Trypanosoma brucei unspecified product 0.0018 0.004 0.1647
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0002 0.0002
Loa Loa (eye worm) MBCTL1 0.0051 0.0232 0.0434
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.028 0.028
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0016 0.0029 0.0246
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0733 0.2298
Leishmania major 4-coumarate:coa ligase-like protein 0.0033 0.0128 0.5771
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0198 0.1084 0.203
Leishmania major 4-coumarate:coa ligase-like protein 0.0033 0.0128 0.5771
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0038 0.0158 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0128 0.0255
Echinococcus multilocularis snurportin 1 0.0198 0.1084 0.1084
Onchocerca volvulus 0.0134 0.0712 0.1162
Schistosoma mansoni thyroid hormone receptor 0.0016 0.0027 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0016 0.0027 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Echinococcus granulosus FTZ F1 alpha 0.0016 0.0027 0.0084
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.004 0.1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0733 0.2298
Mycobacterium ulcerans acyl-CoA synthetase 0.0033 0.0128 0.0255
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0047 0.0206 0.0647
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0162 0.0877 0.2749
Mycobacterium ulcerans short chain dehydrogenase 0.0189 0.1033 0.2586
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0051 0.0232 0.0726
Schistosoma mansoni hypothetical protein 0.0163 0.0882 0.2764
Echinococcus multilocularis cpg binding protein 0.0033 0.0123 0.0123
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0025 0.0079 0.0128
Echinococcus granulosus ecdysone induced protein 78C 0.0016 0.0027 0.0084
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0016 0.0027 0.005
Onchocerca volvulus 0.0045 0.0195 0.0312
Mycobacterium tuberculosis Probable esterase LipL 0.0047 0.0206 0.0456
Trypanosoma cruzi DNA polymerase kappa, putative 0.0018 0.004 0.1
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Schistosoma mansoni jumonji domain containing protein 0.0051 0.0234 0.0732
Schistosoma mansoni coup transcription factor 0.0016 0.0027 0.0084
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0029 0.0436
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0045 0.0199 0.0372
Mycobacterium ulcerans hypothetical protein 0.0033 0.0128 0.0255
Schistosoma mansoni myelin transcription factor 1 myt1 0.0051 0.0232 0.0726
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0033 0.0128 0.0255
Schistosoma mansoni steroid hormone receptor ad4bp 0.0016 0.0027 0.0084
Schistosoma mansoni lamin 0.0045 0.0199 0.0623
Mycobacterium tuberculosis Probable hydrolase 0.0047 0.0206 0.0456
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0022 0.0061 0.0193
Echinococcus granulosus L aminoadipate semialdehyde 0.0137 0.0731 0.2291
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0018 0.004 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0148
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0352 0.1103
Loa Loa (eye worm) hypothetical protein 0.0045 0.0195 0.0366
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1022 0.1649
Echinococcus granulosus GPCR family 2 0.0075 0.0372 0.1168
Brugia malayi Pre-SET motif family protein 0.0134 0.0712 0.1334
Onchocerca volvulus Glucosylceramidase homolog 0.0123 0.0648 0.1055
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.035 0.035
Echinococcus multilocularis tumor protein p63 0.0224 0.1237 0.1237
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.1022 0.1649
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.0733 0.1373
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.002 0.0049 0.0153
Schistosoma mansoni hypothetical protein 0.0395 0.2237 0.7015
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.035 0.1096
Entamoeba histolytica acyl-CoA synthetase, putative 0.0033 0.0128 0.3254
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0016 0.0027 0.0027
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0033 0.0128 0.0255
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0134 0.0712 0.0712
Plasmodium falciparum importin beta, putative 0.0019 0.0041 0.0957
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0134 0.0712 0.2233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0148
Echinococcus granulosus tar DNA binding protein 0.0137 0.0733 0.2298
Trichomonas vaginalis ap endonuclease, putative 0.0016 0.0029 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0072 0.0352 0.0659
Brugia malayi cytoplasmic intermediate filament protein 0.0024 0.0076 0.0141
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0133 0.0249
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0047 0.0206 0.0386
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0016 0.0027 0.005
Leishmania major phosphopantetheinyl transferase-like protein 0.0038 0.0158 0.7382
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Echinococcus multilocularis histone acetyltransferase MYST2 0.0051 0.0232 0.0232
Echinococcus multilocularis jumonji domain containing protein 0.0028 0.0094 0.0094
Echinococcus granulosus jumonji domain containing protein 0.0028 0.0094 0.0295
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0038 0.0158 0.1883
Onchocerca volvulus 0.0028 0.0095 0.0147
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0016 0.0027 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0167 0.0908 0.17
Trichomonas vaginalis glucosylceramidase, putative 0.0123 0.0648 0.1033
Trichomonas vaginalis penicillin-binding protein, putative 0.0047 0.0206 0.0305
Echinococcus multilocularis dna polymerase eta 0.0018 0.004 0.004
Mycobacterium tuberculosis Conserved hypothetical protein 0.0018 0.004 0.0027
Brugia malayi Bromodomain containing protein 0.0024 0.0072 0.0134
Schistosoma mansoni terminal deoxycytidyl transferase 0.0018 0.004 0.0124
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0072 0.0352 0.0352
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0028 0.0098 0.0098
Echinococcus granulosus fetal alzheimer antigen falz 0.0039 0.016 0.0503
Entamoeba histolytica deoxycytidyl transferase, putative 0.0018 0.004 0.0564
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0039 0.016 0.0503
Schistosoma mansoni cpg binding protein 0.0028 0.0095 0.0299
Leishmania major hypothetical protein, conserved 0.0047 0.0206 1
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0206 0.0443
Trichomonas vaginalis penicillin-binding protein, putative 0.0047 0.0206 0.0305
Trypanosoma brucei DNA polymerase eta, putative 0.0018 0.004 0.1647
Brugia malayi nuclear receptor NHR-88 0.0016 0.0027 0.005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0016 0.0027 0.0084
Echinococcus granulosus PHD finger protein rhinoceros 0.002 0.0049 0.0153
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0038 0.0158 0.0331
Brugia malayi Bromodomain containing protein 0.0126 0.0667 0.1248
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0016 0.0027 0.0027
Onchocerca volvulus 0.0047 0.0206 0.033
Trypanosoma cruzi hypothetical protein, conserved 0.0047 0.0206 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0029 0.0091
Brugia malayi Latrophilin receptor protein 2 0.0075 0.0372 0.0697
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0206 0.0305
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0047 0.0206 0.0647
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0158 0.757
Echinococcus granulosus peregrin 0.0024 0.0072 0.0225
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0027 0.0027
Onchocerca volvulus 0.0033 0.0128 0.0201
Entamoeba histolytica hypothetical protein 0.0071 0.035 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0148
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0016 0.0027 0.0035
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0024 0.0076 0.0141
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0239
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0072 0.0352 0.1103
Entamoeba histolytica acyl-coA synthetase, putative 0.0033 0.0128 0.3254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0072 0.0352 0.1103
Trypanosoma cruzi PAB1-binding protein , putative 0.0017 0.003 0.05
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0033 0.0128 0.0255
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0049 0.0091
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0206 0.2594
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Loa Loa (eye worm) hypothetical protein 0.002 0.0049 0.0091
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0128 0.068 0.2133
Mycobacterium ulcerans imidazoleglycerol-phosphate dehydratase 0.0683 0.3913 1
Trichomonas vaginalis D-aminoacylase, putative 0.0047 0.0206 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0016 0.0027 0.005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0047 0.0206 0.0456
Mycobacterium ulcerans lipase LipD 0.0047 0.0206 0.0456
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0172 0.0321
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0016 0.0027 0.005
Leishmania major DNA polymerase eta, putative 0.0018 0.004 0.1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0187 0.1022 0.1913
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0016 0.0027 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0018 0.004 0.1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0079 0.0148
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2237 0.7015
Brugia malayi RNA, U transporter 1 0.0053 0.024 0.045
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0038 0.0158 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0016 0.0027 0.0035
Echinococcus granulosus lamin 0.0045 0.0199 0.0623
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0068 0.0127
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0075 0.0372 0.1168
Echinococcus multilocularis tar DNA binding protein 0.0137 0.0733 0.0733
Schistosoma mansoni tar DNA-binding protein 0.0137 0.0733 0.2298
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0051 0.0232 0.0434
Leishmania major DNA polymerase kappa, putative 0.0018 0.004 0.1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.004 0.1647
Trichomonas vaginalis DNA polymerase eta, putative 0.0018 0.004 0.0031
Plasmodium vivax acyl-CoA synthetase, putative 0.0025 0.0079 0.0728
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0018 0.004 0.0074
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0016 0.0027 0.0084
Loa Loa (eye worm) beta-lactamase 0.0047 0.0206 0.0386
Brugia malayi hypothetical protein 0.0017 0.003 0.0057
Mycobacterium tuberculosis Probable oxidoreductase 0.0189 0.1033 0.2586
Echinococcus multilocularis dna polymerase kappa 0.0018 0.004 0.004
Loa Loa (eye worm) steroid hormone receptor 0.0016 0.0027 0.005
Echinococcus granulosus lysine specific demethylase 5A 0.0029 0.0101 0.0316
Trichomonas vaginalis esterase, putative 0.0047 0.0206 0.0305
Schistosoma mansoni DNA polymerase eta 0.0018 0.004 0.0124
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0047 0.0206 0.0456
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0386
Plasmodium falciparum phd finger protein, putative 0.002 0.0049 0.1538
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0047 0.0206 0.0456
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0016 0.0027 0.0027
Brugia malayi hypothetical protein 0.0071 0.035 0.0654
Toxoplasma gondii LsmAD domain-containing protein 0.0017 0.003 0.0018
Schistosoma mansoni hypothetical protein 0.0025 0.0081 0.0255
Echinococcus multilocularis neuropeptide receptor 0.0084 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0047 0.0206 0.0386

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.8 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
IC50 (binding) = 2.8 uM Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 0.7 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Ki (binding) = 0.7 uM Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans ChEMBL. 10450980
Kis (binding) = 3.95 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980
Kis (binding) = 3.95 uM Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD) ChEMBL. 10450980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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