Detailed information for compound 1058476

Basic information

Technical information
  • TDR Targets ID: 1058476
  • Name: 2-(3-oxo-2-phenylpyrazolo[5,4-b]pyridin-1-yl) -N-(phenylmethyl)acetamide
  • MW: 358.393 | Formula: C21H18N4O2
  • H donors: 1 H acceptors: 3 LogP: 3.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1n(c2ccccc2)c(=O)c2c1nccc2)NCc1ccccc1
  • InChi: 1S/C21H18N4O2/c26-19(23-14-16-8-3-1-4-9-16)15-24-20-18(12-7-13-22-20)21(27)25(24)17-10-5-2-6-11-17/h1-13H,14-15H2,(H,23,26)
  • InChiKey: JRTVTVGQWMVZKC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3-oxo-2-phenyl-pyrazolo[5,4-b]pyridin-1-yl)-N-(phenylmethyl)acetamide
  • 2-(3-oxo-2-phenyl-1-pyrazolo[5,4-b]pyridinyl)-N-(phenylmethyl)acetamide
  • N-(benzyl)-2-(3-keto-2-phenyl-pyrazolo[5,4-b]pyridin-1-yl)acetamide
  • 2-(3-oxo-2-phenyl-pyrazolo[5,4-b]pyridin-1-yl)-N-(phenylmethyl)ethanamide
  • G024-0384
  • NCGC00128388-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neuropeptide s receptor 0.0493 0.5414 0.6643
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0012
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0108 0.0107
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0673 0.0825
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0009 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Echinococcus granulosus microtubule associated protein 2 0.0734 0.8149 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0469 0.0574
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1462 0.4417
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0469 0.2837
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0296 0.0891
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0141 0.0171
Toxoplasma gondii sugar transporter ST3 0.003 0.0141 0.0211
Schistosoma mansoni bromodomain containing protein 0.0067 0.0568 0.0696
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Schistosoma mansoni lozenge 0.0057 0.0448 0.0548
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0569 0.0697
Trypanosoma cruzi metacaspase, putative 0.0045 0.0316 0.0953
Giardia lamblia Kinase, CMGC MAPK 0.011 0.1057 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.1694 0.3427
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0375 0.113
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0006 0.0004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Brugia malayi PHD-finger family protein 0.0026 0.0104 0.0211
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0019 0.0022 0.0025
Plasmodium vivax metacaspase 1, putative 0.0045 0.0316 0.0315
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0009 0.001
Schistosoma mansoni sugar transporter 0.003 0.0141 0.0171
Brugia malayi Sugar transporter family protein 0.003 0.0141 0.0285
Onchocerca volvulus 0.003 0.0141 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0339 0.1021
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0163 0.1656 0.1655
Leishmania major cathepsin L-like protease 0.0018 0.0006 0.0013
Plasmodium falciparum thioredoxin reductase 0.005 0.0375 0.0374
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0992 0.1216
Onchocerca volvulus 0.003 0.0141 0.0273
Trypanosoma cruzi glucose transporter, putative 0.003 0.0141 0.0421
Trypanosoma cruzi hexose transporter, putative 0.0036 0.021 0.0631
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0019 0.0022 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0523 0.1048
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0547 0.1652
Trypanosoma brucei glucosidase, putative 0.0037 0.0223 0.0669
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0022 0.0033
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0339 0.0414
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0339 0.1021
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0019 0.0022 0.0021
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0026 0.0104 0.0309
Schistosoma mansoni glucose transport protein 0.0211 0.2203 0.2702
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0569 1
Schistosoma mansoni microtubule-associated protein tau 0.0734 0.8149 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1694 0.1761
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Loa Loa (eye worm) hypothetical protein 0.0075 0.0658 0.1322
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0141 0.0145
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0026 0.0104 0.0125
Echinococcus granulosus peptidase Clp S14 family 0.0107 0.1018 0.1248
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0547 0.1952
Giardia lamblia Hexose transporter 0.003 0.0141 0.132
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0547 0.1952
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.2519 0.5092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0339 0.2039
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0141 0.0421
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0673 0.1353
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0673 0.0825
Loa Loa (eye worm) hypothetical protein 0.0045 0.0316 0.063
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0223 0.0791
Echinococcus granulosus cathepsin l1 0.0018 0.0006 0.0005
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0141 0.0211
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2702
Schistosoma mansoni hypothetical protein 0.0173 0.1769 0.217
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0006 0.0004
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0141 0.0273
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0223 0.0791
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.011 0.1057 0.3192
Echinococcus multilocularis serine protein kinase ATM 0.0026 0.0104 0.0106
Echinococcus multilocularis mitogen activated protein kinase 3 0.011 0.1057 0.1098
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0339 0.0414
Loa Loa (eye worm) hypothetical protein 0.0047 0.0339 0.0675
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0019 0.0022 0.0062
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.057
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0151 0.0184
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0066 0.0549 0.1656
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0575 0.1734
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.28 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0523 0.0641
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0247 0.0301
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.0672
Loa Loa (eye worm) hypothetical protein 0.0452 0.4943 1
Trypanosoma cruzi metacaspase, putative 0.0045 0.0316 0.0953
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0643 0.0641
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Plasmodium vivax CDK-related protein kinase 6, putative 0.0896 1 1
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0643 0.0641
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0076 0.0091
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0342 0.3692 0.5598
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0382 0.0772
Schistosoma mansoni sugar transporter 0.003 0.0141 0.0171
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0066 0.0549 0.0831
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.0525 0.0545
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0339 0.0577
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0006 0.0005
Onchocerca volvulus 0.003 0.0141 0.0273
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0992 0.1216
Loa Loa (eye worm) phosphatidylinositol 3 0.0019 0.0022 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0164 0.02
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0066 0.0549 0.0548
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0066 0.0549 0.1101
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0339 0.2039
Loa Loa (eye worm) hypothetical protein 0.0051 0.0388 0.0775
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0673 0.0699
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0223 0.0669
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0038 0.0238 0.029
Schistosoma mansoni alpha glucosidase 0.0037 0.0223 0.0272
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0108 0.0107
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0223 0.0791
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0596 0.073
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0673 0.0825
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0019 0.0022 0.0062
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0022 0.0062
Leishmania major glucose transporter, lmgt3 0.0065 0.0547 0.1652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.0672
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0019 0.0022 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0316 0.1126
Brugia malayi major facilitator superfamily protein 0.003 0.0141 0.0285
Brugia malayi Probable ClpP-like protease 0.0163 0.1656 0.3351
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0141 0.0498
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0643 0.1939
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0493 0.0603
Toxoplasma gondii cathepsin CPL 0.0018 0.0006 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0549 0.1957
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1462 0.4417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Loa Loa (eye worm) hypothetical protein 0.0027 0.0108 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Entamoeba histolytica protein kinase, putative 0.0066 0.0549 0.9642
Onchocerca volvulus Putative transporter 0.003 0.0141 0.0273
Echinococcus multilocularis caspase 3 0.0074 0.0647 0.0672
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0019 0.0022 0.0288
Plasmodium falciparum glutathione reductase 0.005 0.0375 0.0374
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0012
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0066 0.0549 0.0548
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0316 0.0953
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0199 0.0402
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0107 0.1018 0.6169
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Leishmania major phosphatidylinositol 3-kinase, putative 0.0019 0.0022 0.0062
Plasmodium vivax hexose transporter 0.0211 0.2203 0.2202
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0673 0.1353
Trypanosoma brucei metacaspase MCA3 0.0045 0.0316 0.0953
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0099 0.0188
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0575 0.1734
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.0992 0.1031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Echinococcus granulosus geminin 0.0173 0.1769 0.217
Schistosoma mansoni glucose transport protein 0.0211 0.2203 0.2702
Toxoplasma gondii hypothetical protein 0.0056 0.0442 0.0668
Echinococcus granulosus neuropeptide receptor A26 0.0493 0.5414 0.6643
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.3308 1
Onchocerca volvulus 0.003 0.0141 0.0273
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.041 0.1235
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0339 0.0338
Onchocerca volvulus 0.003 0.0141 0.0273
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0223 0.0791
Plasmodium vivax glutathione reductase, putative 0.005 0.0375 0.0374
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0575 0.1734
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0339 0.0414
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Onchocerca volvulus 0.0452 0.4943 1
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0045 0.0316 0.0387
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Leishmania major hypothetical protein, conserved 0.003 0.0141 0.0421
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Plasmodium falciparum metacaspase 1 0.0045 0.0316 0.0315
Brugia malayi follicle stimulating hormone receptor 0.0239 0.2519 0.5097
Loa Loa (eye worm) hypothetical protein 0.0066 0.0549 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0223 0.0669
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.0596 0.073
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0316 0.0478
Loa Loa (eye worm) hypothetical protein 0.0452 0.4943 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0992 0.1216
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0316 0.1126
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0296 0.0891
Leishmania major metacaspase, putative 0.0045 0.0316 0.0953
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0141 0.0498
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.1253 0.7597
Plasmodium vivax sugar transporter, putative 0.003 0.0141 0.0139
Giardia lamblia Sugar-proton symporter 0.003 0.0141 0.132
Leishmania major cathepsin L-like protease 0.0018 0.0006 0.0013
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0375 0.0389
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Brugia malayi hypothetical protein 0.0452 0.4943 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0108 0.0323
Plasmodium falciparum calcium-dependent protein kinase 4 0.0066 0.0549 0.0548
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.011 0.1057 0.16
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0523 0.4946
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0006 0.0013
Trypanosoma cruzi sugar transporter, putative 0.003 0.0141 0.0421
Onchocerca volvulus Cell death protein 3 homolog 0.0087 0.0795 0.1598
Onchocerca volvulus 0.0042 0.0281 0.0558
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0523 0.1059
Chlamydia trachomatis proline--tRNA ligase 0.0022 0.0058 0.0339
Loa Loa (eye worm) hypothetical protein 0.0041 0.0267 0.053
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0643 0.1939
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0547 0.1652
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.1253 0.7597
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.3308 1
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0523 0.1865
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.3308 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0019 0.0022 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0316 0.1126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.037 0.0453
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1108 0.6076
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0141 0.0171
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.011 0.1057 0.3192
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Loa Loa (eye worm) hypothetical protein 0.007 0.0596 0.1195
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0523 0.0641
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0339 0.0686
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0569 0.1141
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma brucei metacaspase 0.0045 0.0316 0.0953
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0273 0.097
Loa Loa (eye worm) hypothetical protein 0.0163 0.1656 0.3343
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0296 0.0891
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0053 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Echinococcus multilocularis caspase 0.0119 0.116 0.1206
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0163 0.1656 0.1722
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.1253 0.7597
Schistosoma mansoni sugar transporter 0.003 0.0141 0.0171
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0547 0.1652
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0019 0.0022 0.0062
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0493 0.0511
Loa Loa (eye worm) hypothetical protein 0.0045 0.0319 0.0635
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0547 0.1652
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0066 0.0549 0.0672
Onchocerca volvulus 0.003 0.0141 0.0273
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0141 0.0421
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0006 0.0015
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0523 0.9185
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0141 0.0285
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0316 0.0478
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0223 0.3851
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0141 0.0498
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.1057 0.3192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Leishmania major cathepsin L-like protease 0.0068 0.0575 0.1734
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0006 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1057 0.1295
Echinococcus granulosus caspase 2 0.0087 0.0795 0.0974
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0569 0.1717
Brugia malayi Melibiase family protein 0.007 0.0596 0.1205
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0442 0.266
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1108 0.6714
Echinococcus multilocularis cysteine protease 0.0018 0.0006 0.0005
Schistosoma mansoni hypothetical protein 0.0211 0.2203 0.2702
Schistosoma mansoni glucose transport protein 0.0211 0.2203 0.2702
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0141 0.0842
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Brugia malayi hypothetical protein 0.0042 0.0281 0.0569
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0469 0.0949
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0569 0.0697
Loa Loa (eye worm) hypothetical protein 0.0063 0.0523 0.1048
Toxoplasma gondii FATC domain-containing protein 0.0026 0.0104 0.0155
Onchocerca volvulus 0.003 0.0141 0.0273
Leishmania major hypothetical protein, conserved 0.0027 0.0108 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0547 0.1952
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1057 0.3771
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.011 0.1057 0.3192
Brugia malayi MAP kinase sur-1 0.011 0.1057 0.2138
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0223 0.0791
Trypanosoma cruzi metacaspase 5, putative 0.0045 0.0316 0.0953
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0141 0.0845
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0223 0.0451
Toxoplasma gondii hypothetical protein 0.005 0.0368 0.0557
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0119 0.116 0.1422
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0012
Echinococcus granulosus mitogen activated protein kinase 3 0.011 0.1057 0.1295
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Plasmodium vivax vivapain-2 0.0018 0.0006 0.0004
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0107 0.1018 0.5434
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1108 0.6714
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0045 0.0316 0.064
Brugia malayi hypothetical protein 0.003 0.0141 0.0285
Schistosoma mansoni alpha-glucosidase 0.0143 0.143 0.1754
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0026 0.0104 0.0309
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0281 0.0291
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0247 0.0255
Brugia malayi Pre-SET motif family protein 0.0032 0.0164 0.0332
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0066 0.0549 0.1101
Onchocerca volvulus 0.0096 0.0897 0.1805
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.0992 0.1216
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0006 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0469 0.2825
Echinococcus granulosus caspase 0.0119 0.116 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma cruzi hexose transporter, putative 0.003 0.0141 0.0421
Schistosoma mansoni protein kinase 0.0066 0.0549 0.0672
Trypanosoma brucei sugar transporter, putative 0.003 0.0141 0.0421
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0009 0.001
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.1656 0.251
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2291
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0281 0.0344
Toxoplasma gondii thioredoxin reductase 0.005 0.0375 0.0567
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0258 0.1558
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0141 0.0273
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0141 0.0171
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0223 0.0791
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0006 0.0013
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0108 0.0323
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0045 0.0316 0.0478
Brugia malayi hypothetical protein 0.0027 0.0108 0.0219
Onchocerca volvulus 0.003 0.0141 0.0273
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.0596 0.2124
Echinococcus granulosus solute carrier family 22 0.003 0.0141 0.0171
Brugia malayi Cell death protein 3 precursor 0.0087 0.0795 0.1607
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.037 0.0384
Loa Loa (eye worm) sugar transporter 0.003 0.0141 0.0273
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.28 0.5665
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0547 0.1952
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.1694 0.1761
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.28 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0316 0.1126
Plasmodium vivax calcium-dependent protein kinase, putative 0.0066 0.0549 0.0548
Toxoplasma gondii melibiase subfamily protein 0.0104 0.0992 0.1502
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.3308 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0141 0.0285
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0012
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1057 0.3771
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0038 0.0238 0.0246
Echinococcus multilocularis solute carrier family 22 0.003 0.0141 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Loa Loa (eye worm) hypothetical protein 0.0087 0.0795 0.1598
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0022 0.0044
Echinococcus granulosus solute carrier family 22 0.003 0.0141 0.0171
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0141 0.0842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0643 0.1939
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0547 0.1652
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0339 0.3199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0382 0.0761
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Plasmodium vivax vivapain-2 0.0018 0.0006 0.0004
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0022 0.0044
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0022 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Echinococcus multilocularis microtubule associated protein 2 0.0734 0.8149 0.8479
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.057
Leishmania major cathepsin L-like protease 0.0018 0.0006 0.0013
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0223 0.044
Leishmania major cathepsin L-like protease 0.0068 0.0575 0.1734
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Plasmodium vivax SET domain protein, putative 0.0032 0.0164 0.0163
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Loa Loa (eye worm) sugar transporter 0.0211 0.2203 0.4451
Schistosoma mansoni zinc finger protein 0.0021 0.004 0.0047
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.0672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Onchocerca volvulus 0.003 0.0141 0.0273
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0375 0.0748
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.0992 0.1031
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0523 0.0641
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0342 0.3692 0.3691
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2702
Schistosoma mansoni peptidase Clp (S14 family) 0.0163 0.1656 0.2031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0375 0.2268
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0076 0.0091
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trichomonas vaginalis glucose transporter, putative 0.003 0.0141 0.0498
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.0525 0.0643
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.1649 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0026 0.0104 0.021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trypanosoma cruzi metacaspase, putative 0.0045 0.0316 0.0953
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0569 0.1717
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0141 0.0842
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0508 0.1532
Echinococcus granulosus mitogen activated protein kinase 0.011 0.1057 0.1295
Echinococcus multilocularis cysteine protease 0.0018 0.0006 0.0005
Brugia malayi Pre-SET motif family protein 0.0221 0.232 0.4694
Echinococcus multilocularis solute carrier family 22 0.003 0.0141 0.0145
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0375 0.0374
Trypanosoma brucei Metacaspase-4 0.0045 0.0316 0.0953
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.011 0.1057 0.2129
Brugia malayi major facilitator superfamily protein 0.003 0.0141 0.0285
Echinococcus granulosus caspase 8 0.0045 0.0316 0.0387
Onchocerca volvulus 0.003 0.0141 0.0273
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0019 0.0022 0.0062
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0119 0.116 0.1206
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0001 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0006 0.0012
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Brugia malayi Sugar transporter family protein 0.003 0.0141 0.0285
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0019 0.0022 0.0062
Trypanosoma brucei metacaspase MCA2 0.0045 0.0316 0.0953
Echinococcus multilocularis neuropeptide s receptor 0.0493 0.5414 0.5633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0006 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0547 0.1952
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0569 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Echinococcus multilocularis solute carrier family 22 0.003 0.0141 0.0145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Echinococcus multilocularis caspase 8 0.0045 0.0316 0.0328
Echinococcus granulosus General substrate transporter 0.0181 0.1866 0.2288
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0066 0.0549 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0569 0.1717
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.28 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0066 0.0549 0.0548
Loa Loa (eye worm) hypothetical protein 0.0051 0.0382 0.0761
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0006 0.0005
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Loa Loa (eye worm) RNA binding protein 0.0076 0.0673 0.1353
Echinococcus multilocularis Protein lozenge 0.0057 0.0448 0.0465
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0056 0.0442 0.044
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1462 0.4417
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0163 0.1656 0.2031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.0113
Echinococcus multilocularis General substrate transporter 0.0181 0.1866 0.194
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.057
Loa Loa (eye worm) hypothetical protein 0.0043 0.0296 0.0588
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0141 0.0845
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0141 0.0145
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Schistosoma mansoni sugar transporter 0.003 0.0141 0.0171
Plasmodium falciparum protein kinase 7 0.0597 0.6595 0.6594
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0549 0.0672
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0006 0.0005
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0296 0.0891
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0316 0.1126
Trypanosoma brucei trypanothione reductase 0.005 0.0375 0.113
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0022 0.0058 0.0339
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0673 0.0825
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.28 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0107 0.1018 0.1058
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0012
Onchocerca volvulus 0.0032 0.0164 0.0321
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0163 0.1656 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0066 0.0549 0.0548
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0108 0.0162
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.28 0.566
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0523 0.0543
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0575 0.1734
Mycobacterium ulcerans hypothetical protein 0.0162 0.1649 0.9956
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1108 0.6714
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 1
Brugia malayi hypothetical protein 0.003 0.0141 0.0285
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0019 0.0022 0.0062
Loa Loa (eye worm) hypothetical protein 0.0042 0.0281 0.0558
Echinococcus granulosus zinc finger protein 0.0021 0.004 0.0047
Onchocerca volvulus 0.003 0.0141 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0104 0.0365
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0223 0.0791
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0223 0.3851
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1057 0.3771
Echinococcus granulosus solute carrier family 22 0.003 0.0141 0.0171
Brugia malayi Bromodomain containing protein 0.0041 0.0266 0.0539
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Plasmodium vivax hypothetical protein, conserved 0.0045 0.0316 0.0315
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0469 0.2825
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0019 0.0022 0.0062
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 0.1655
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1108 0.6714
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0019 0.0022 0.0288
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1108 0.6714
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0339 0.0351
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0164 0.02
Trypanosoma brucei metacaspase 5, putative 0.0045 0.0316 0.0953
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0339 0.0512
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0469 0.0487
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0019 0.0022 0.0062
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2702
Schistosoma mansoni hypothetical protein 0.0173 0.1769 0.217
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0523 0.1896
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Brugia malayi Sugar transporter family protein 0.0211 0.2203 0.4457
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0547 0.1652
Trypanosoma brucei glucose transporter 1E 0.0065 0.0547 0.1652
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0339 0.0338
Echinococcus multilocularis neuropeptide receptor A26 0.0493 0.5414 0.5633
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0862 0.961 1
Leishmania major cathepsin L-like protease 0.0018 0.0006 0.0013
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2291
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1875 0.6696
Trichomonas vaginalis conserved hypothetical protein 0.0211 0.2203 0.7868
Onchocerca volvulus 0.003 0.0141 0.0273
Loa Loa (eye worm) glutathione reductase 0.005 0.0375 0.0748
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0569 0.1717
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Brugia malayi Cathepsin L-like precursor 0.0018 0.0006 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Mycobacterium tuberculosis Probable reductase 0.0115 0.1108 0.6714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0076 0.0078
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0017 0.0023
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0107 0.1018 0.6169
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0141 0.0498
Onchocerca volvulus 0.003 0.0141 0.0273
Leishmania major trypanothione reductase 0.005 0.0375 0.113
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.011 0.1057 0.3192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Schistosoma mansoni protein kinase 0.0066 0.0549 0.0672
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0223 0.0336
Onchocerca volvulus 0.003 0.0141 0.0273
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0141 0.0498
Brugia malayi Bromodomain containing protein 0.008 0.071 0.1437
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0223 0.0791
Schistosoma mansoni hypothetical protein 0.0035 0.0199 0.0242
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0141 0.0498
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0258 0.1558
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.1694 0.3419
Schistosoma mansoni caspase-7 (C14 family) 0.0087 0.0795 0.0974
Leishmania major protein kinase, putative 0.0066 0.0549 0.1656
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0006 0.0005
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 1
Onchocerca volvulus 0.003 0.0141 0.0273
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0569 0.0591
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0141 0.0842
Giardia lamblia GTOR 0.0019 0.0022 0.0195
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0058 0.0339
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0019 0.0022 0.0062
Plasmodium falciparum calcium-dependent protein kinase 3 0.0066 0.0549 0.0548
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Mycobacterium ulcerans sugar transporter 0.003 0.0141 0.0842
Toxoplasma gondii protein kinase, putative 0.0597 0.6595 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0019 0.0022 0.0021
Plasmodium falciparum hexose transporter 0.0211 0.2203 0.2202
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0339 0.1021
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0339 0.2039
Trypanosoma cruzi target of rapamycin kinase 3 0.0019 0.0022 0.0062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0382 0.0772
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2702
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0673 0.1363
Trichomonas vaginalis CMGC family protein kinase 0.011 0.1057 0.3771
Loa Loa (eye worm) hypothetical protein 0.005 0.037 0.0739
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0056 0.0442 0.1312
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0141 0.0285
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0469 0.1414
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0063
Leishmania major glucose transporter, lmgt2 0.0065 0.0547 0.1652
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0019 0.0022 0.0025
Echinococcus granulosus caspase 3 0.0074 0.0647 0.0792
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0066 0.0549 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0223 0.0669
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.0992 0.1216
Entamoeba histolytica hypothetical protein 0.0047 0.0339 0.5913
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0223 0.0272
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0066 0.0549 0.057
Onchocerca volvulus 0.0252 0.2668 0.5392
Toxoplasma gondii sugar transporter ST2 0.003 0.0141 0.0211
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0163 0.1656 0.251
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0339 0.1206
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.037 0.0453
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1769 0.6318
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.28 1
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0141 0.0139
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.1253 0.7117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0019 0.0022 0.0062
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0022 0.0063
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0045 0.0316 0.1126
Schistosoma mansoni alpha-glucosidase 0.0143 0.143 0.1754
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0223 0.0791
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0424 0.0847
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0164 0.0247
Echinococcus multilocularis mitogen activated protein kinase 0.011 0.1057 0.1098
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0108 0.0107
Echinococcus multilocularis geminin 0.0173 0.1769 0.184
Trichomonas vaginalis set domain proteins, putative 0.0252 0.2668 0.9529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0006 0.0015
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.011 0.1057 0.3192
Brugia malayi Thioredoxin reductase 0.005 0.0375 0.0759
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0056 0.0442 0.044
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0141 0.0498
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma brucei protein kinase, putative 0.011 0.1057 0.3192
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0108 0.0323
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0221 0.232 0.4688
Brugia malayi Cam kinase protein 1 0.0066 0.0549 0.1111
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0375 0.0459
Plasmodium falciparum calcium-dependent protein kinase 5 0.0066 0.0549 0.0548
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0211 0.2203 0.2291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.1694 0.2077
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.011 0.1057 0.3192
Brugia malayi glutathione reductase 0.005 0.0375 0.0759
Echinococcus granulosus tar DNA binding protein 0.0076 0.0673 0.0825
Brugia malayi TAR-binding protein 0.0076 0.0673 0.1363
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0547 0.1952
Entamoeba histolytica protein kinase, putative 0.0066 0.0549 0.9642
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Toxoplasma gondii facilitative glucose transporter GT1 0.0211 0.2203 0.3339
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0019 0.0022 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0316 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.28 1
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1875 0.6696
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0066 0.0549 0.0548
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0643 0.0972
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0164 0.0169
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0006 0.0004
Trypanosoma brucei glucose transporter, putative 0.0065 0.0547 0.1652
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0211 0.2203 0.2291
Leishmania major cathepsin L-like protease 0.0018 0.0006 0.0013
Toxoplasma gondii sugar transporter ST1 0.003 0.0141 0.0211
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0643 0.1939
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0547 0.1652
Echinococcus multilocularis solute carrier family 22 0.003 0.0141 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Echinococcus granulosus solute carrier family 22 0.003 0.0141 0.0171
Plasmodium falciparum metacaspase-like protein 0.0045 0.0316 0.0315
Echinococcus granulosus serine protein kinase ATM 0.0026 0.0104 0.0125
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0019 0.0022 0.0025
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0009 0.001
Trypanosoma brucei glucose transporter 2A 0.0065 0.0547 0.1652
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0006 0.0005
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0066 0.0549 0.0831
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0062 0.0182
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0404 0.1217
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0223 0.023
Echinococcus multilocularis zinc finger protein 0.0021 0.004 0.004
Loa Loa (eye worm) runx1 0.0057 0.0448 0.0896
Schistosoma mansoni hypothetical protein 0.0042 0.0281 0.0344
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0022 0.0073
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0523 0.1059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0199 0.0391
Schistosoma mansoni caspase-7 (C14 family) 0.0119 0.116 0.1422
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0643 0.1939
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Onchocerca volvulus 0.003 0.0141 0.0273
Leishmania major cathepsin L-like protease 0.0068 0.0575 0.1734
Loa Loa (eye worm) hypothetical protein 0.003 0.0141 0.0273
Trypanosoma cruzi metacaspase, putative 0.0045 0.0316 0.0953
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0469 0.0574
Brugia malayi hypothetical protein 0.003 0.0141 0.0285
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0006 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0673 0.0825
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0163 0.1656 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0342 0.3692 0.3691
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Trypanosoma cruzi hexose transporter 0.0065 0.0547 0.1652
Brugia malayi RNA binding protein 0.0076 0.0673 0.1363
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0547 0.1952
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.1769 0.3572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.037 0.0453
Echinococcus multilocularis caspase 2 0.0087 0.0795 0.0825
Schistosoma mansoni caspase-3 (C14 family) 0.0119 0.116 0.1422
Leishmania major glucose transporter, lmgt1 0.0065 0.0547 0.1652
Entamoeba histolytica hypothetical protein 0.0026 0.0104 0.1738
Trichomonas vaginalis sugar transporter, putative 0.003 0.0141 0.0498
Schistosoma mansoni glucose transporter 0.003 0.0141 0.0171
Schistosoma mansoni protein kinase 0.0066 0.0549 0.0672
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0575 0.1734

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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