Detailed information for compound 1063208

Basic information

Technical information
  • TDR Targets ID: 1063208
  • Name: 5,6-dihydro-3H-pyrrolo[2,3-d][2]benzazepin-4- one
  • MW: 198.221 | Formula: C12H10N2O
  • H donors: 2 H acceptors: 1 LogP: 1.52 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCc2c(c3c1[nH]cc3)cccc2
  • InChi: 1S/C12H10N2O/c15-12-11-10(5-6-13-11)9-4-2-1-3-8(9)7-14-12/h1-6,13H,7H2,(H,14,15)
  • InChiKey: KXYLSLPDTXTJDD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0023 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0081 0.0229
Leishmania major hypothetical protein, conserved 0.0081 0.016 0.0564
Giardia lamblia GTOR 0.031 0.0716 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0012 0.0035
Schistosoma mansoni smad 0.0101 0.0208 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0034 0.0302
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0328 0.123
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0089 0.025
Onchocerca volvulus 0.0168 0.0372 0.2195
Mycobacterium tuberculosis Probable lipase LipE 0.015 0.0328 0.1389
Schistosoma mansoni lamin 0.0168 0.0372 0.2219
Loa Loa (eye worm) hypothetical protein 0.0081 0.0161 0.0456
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.015 0.0328 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0625 0.3692
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.031 0.0716 0.2718
Echinococcus multilocularis 0.0048 0.0081 0.0081
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0726
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0336 0.0779 0.103
Mycobacterium leprae conserved hypothetical protein 0.015 0.0328 1
Echinococcus multilocularis snurportin 1 0.0303 0.0699 0.0699
Loa Loa (eye worm) hypothetical protein 0.0081 0.016 0.0453
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0081 0.0286
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.031 0.0716 0.2602
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0081 0.0229
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0044
Echinococcus multilocularis mothers against decapentaplegic 5 0.0101 0.0208 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.016 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0023 0.0023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0089 0.0089
Loa Loa (eye worm) transcription factor SMAD2 0.1477 0.3538 1
Entamoeba histolytica cysteine protease, putative 0.0017 0.0007 0.0058
Brugia malayi nuclear receptor RXR 0.0024 0.0023 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0081 0.0229
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0007 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0081 0.0479
Brugia malayi hypothetical protein 0.0081 0.016 0.0453
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0305 0.1802
Onchocerca volvulus 0.0024 0.0023 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.031 0.0716 0.423
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0089 0.025
Schistosoma mansoni Smad4 0.0045 0.0074 0.0441
Brugia malayi Intermediate filament tail domain containing protein 0.0168 0.0372 0.1051
Echinococcus multilocularis lamin dm0 0.0168 0.0372 0.0372
Brugia malayi hypothetical protein 0.0024 0.0023 0.0066
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0081 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0089 0.025
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0007 0.0039
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0292 0.0671 0.9355
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0081 0.0286
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.003 0.0086
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0016 0.0016
Entamoeba histolytica hypothetical protein 0.0476 0.1117 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0048 0.0081 0.0273
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0086
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0074 0.0436
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.031 0.0716 0.0947
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0175 0.039 0.5359
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0157 0.0344 0.5172
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.031 0.0716 0.0716
Brugia malayi conserved hypotetical protein 0.0024 0.0023 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3623
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0175 0.0231
Echinococcus multilocularis cysteine protease 0.0017 0.0007 0.0007
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0141 0.0305 0.0403
Loa Loa (eye worm) hypothetical protein 0.0028 0.0034 0.0095
Loa Loa (eye worm) hypothetical protein 0.0165 0.0364 0.103
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0109 0.0228 0.1361
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.003 0.0086
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.016 0.2101
Mycobacterium tuberculosis Probable hydrolase 0.015 0.0328 0.1389
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.033 0.0933
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Echinococcus multilocularis geminin 0.0559 0.1319 0.1319
Schistosoma mansoni smad 0.0045 0.0074 0.0441
Schistosoma mansoni ran 0.0021 0.0016 0.0093
Onchocerca volvulus 0.0029 0.0036 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.016 0.2357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0671 0.396
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.0573 0.162
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0072 0.0428
Echinococcus multilocularis beta LACTamase domain containing family member 0.015 0.0328 0.0328
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0081 0.0081
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0206 0.0463 0.1308
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0081 0.0484
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0123
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0958 0.2282 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0007 0.0039
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0081 0.0479
Schistosoma mansoni fkbp-rapamycin associated protein 0.0141 0.0305 0.1822
Echinococcus multilocularis dnaJ subfamily B 0.0419 0.0978 0.0978
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0336 0.0779 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0305 0.1802
Schistosoma mansoni hypothetical protein 0.0419 0.0978 0.5842
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.009 0.0183 0.0517
Loa Loa (eye worm) hypothetical protein 0.0141 0.0305 0.0863
Loa Loa (eye worm) hypothetical protein 0.015 0.0328 0.0926
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0063 0.3703
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0081 0.1142
Mycobacterium tuberculosis Conserved protein 0.015 0.0328 0.1389
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0048 0.0081 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0157 0.0344 0.2032
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0089 0.0529
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0081 0.0286
Schistosoma mansoni nuclear receptor 0.0024 0.0023 0.0139
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.015 0.0328 0.1389
Schistosoma mansoni hypothetical protein 0.0476 0.1117 0.6672
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0141 0.0305 0.1144
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0048 0.0081 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0184 0.11
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0184 0.0244
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0305 0.0863
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0089 0.0117
Loa Loa (eye worm) ctsf protein 0.0017 0.0007 0.0018
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0017
Onchocerca volvulus 0.0017 0.0007 0.0039
Brugia malayi MH2 domain containing protein 0.0101 0.0208 0.0589
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0089 0.0117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0671 0.396
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0726
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0048 0.0081 0.0107
Schistosoma mansoni thyroid hormone receptor 0.0178 0.0396 0.2363
Brugia malayi ecdysteroid receptor 0.0051 0.0089 0.025
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0249 0.0568 0.0751
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0089 0.0117
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0023 0.0139
Loa Loa (eye worm) nuclear factor I 0.0056 0.01 0.0282
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0023 0.0138
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0053 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0023 0.0139
Brugia malayi tailless protein 0.0024 0.0023 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0184 0.11
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0063 0.0568
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Echinococcus granulosus cathepsin l1 0.0017 0.0007 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.015 0.0328 0.123
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0012 0.0074
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0048 0.0081 0.0975
Brugia malayi Importin beta-1 subunit 0.0028 0.0034 0.0095
Echinococcus granulosus cpg binding protein 0.0031 0.004 0.0053
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.2321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0228 0.1346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0396 0.234
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Echinococcus multilocularis smad 0.0101 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0172 0.0381 0.1076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3624
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0089 0.025
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.3084
Entamoeba histolytica hypothetical protein 0.0023 0.0021 0.0186
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0007 0.0009
Echinococcus multilocularis lamin 0.0168 0.0372 0.0372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0007 0.0009
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0123 0.0446
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0328 0.1935
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0081 0.0479
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.2321
Onchocerca volvulus 0.015 0.0328 0.1935
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0023 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0035
Entamoeba histolytica hypothetical protein 0.0476 0.1117 1
Echinococcus granulosus tumor protein p63 0.1405 0.3365 0.4449
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0016 0.0035
Schistosoma mansoni lamin 0.0168 0.0372 0.2219
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.031 0.0716 0.2602
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0021 0.0123
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0021 0.0123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0089 0.0089
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0328 0.1935
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0007 0.0007
Mycobacterium ulcerans esterase/lipase LipP 0.015 0.0328 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0007 0.0039
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0048 0.0081 0.4847
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0034 0.0417
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0089 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0023 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0023
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0023 0.0031
Leishmania major phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.0273
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0089 0.0523
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0072 0.101
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0089 0.025
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0573 0.162
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0072 0.0428
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0292 0.0671 0.2436
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.008 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0089 0.025
Echinococcus multilocularis dna polymerase kappa 0.002 0.0012 0.0012
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0081 0.0479
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0023 0.0066
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0336 0.0779 0.2202
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.011 0.0378
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0249 0.0568 0.7896
Schistosoma mansoni hypothetical protein 0.008 0.0157 0.094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0141 0.0305 0.0863
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0016 0.0139
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0048 0.0081 0.4847
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0048 0.0081 0.0484
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0089 0.025
Echinococcus multilocularis musashi 0.0168 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0081 0.0479
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Brugia malayi hypothetical protein 0.0027 0.003 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0089 0.025
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0023 0.0139
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0086 0.0172 0.2268
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.031 0.0716 0.641
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Brugia malayi nuclear receptor RXR 0.0027 0.003 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Onchocerca volvulus 0.0091 0.0184 0.1088
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0048 0.0081 0.0229
Trichomonas vaginalis ran, putative 0.0021 0.0016 0.0092
Schistosoma mansoni smad1 5 8 and 0.0101 0.0208 0.1245
Mycobacterium ulcerans hypothetical protein 0.015 0.0328 1
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0012 0.0074
Giardia lamblia Hypothetical protein 0.0048 0.0081 0.0975
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0023 0.0023
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.011 0.0655
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0012 0.0012
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0074 0.0074
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0249 0.0568 0.1606
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0089 0.0117
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0012 0.0035
Giardia lamblia Phosphatidylinositol 4-kinase 0.0048 0.0081 0.0975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0568 0.3355
Loa Loa (eye worm) hypothetical protein 0.0168 0.0372 0.1051
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0141 0.0305 0.1822
Brugia malayi MH2 domain containing protein 0.0101 0.0208 0.0589
Leishmania major phosphatidylinositol kinase, putative 0.0048 0.0081 0.0273
Brugia malayi cytoplasmic intermediate filament protein 0.009 0.0183 0.0517
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0336 0.0779 0.103
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0476 0.1117 0.1117
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0074 0.0209
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0141 0.0305 0.1144
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.031 0.0716 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0249 0.0568 0.2059
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0249 0.0568 0.7896
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0089 0.0529
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) hypothetical protein 0.015 0.0328 0.0926
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.008 0.0157 0.0157
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0012 0.0075
Schistosoma mansoni cellular tumor antigen P53 0.0206 0.0463 0.2763
Trypanosoma cruzi hypothetical protein, conserved 0.1096 0.2618 1
Schistosoma mansoni nuclear receptor 0.0024 0.0023 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.003 0.0086
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0117 0.169
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0273
Loa Loa (eye worm) cysteine protease 0.0017 0.0007 0.0018
Brugia malayi beta-lactamase 0.015 0.0328 0.0926
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0396 0.234
Schistosoma mansoni hypothetical protein 0.0172 0.0381 0.2274
Mycobacterium tuberculosis Probable esterase LipL 0.015 0.0328 0.1389
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Schistosoma mansoni hypothetical protein 0.008 0.0157 0.094
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0089 0.025
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0089 0.025
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0141 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0559 0.1319 0.7873
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0109 0.0228 0.0228
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0021 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3624
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0081 0.0479
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.003 0.0181
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0081 0.0479
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0089 0.0117
Echinococcus granulosus beta LACTamase domain containing family member 0.015 0.0328 0.0433
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.0726
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0089 0.025
Loa Loa (eye worm) fibroinase 0.0017 0.0007 0.0018
Leishmania major cathepsin L-like protease 0.0065 0.0123 0.0427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Echinococcus granulosus microtubule associated protein 2 0.0707 0.1675 0.2214
Mycobacterium ulcerans lipase LipD 0.015 0.0328 1
Loa Loa (eye worm) intermediate filament protein 0.0168 0.0372 0.1051
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0726
Brugia malayi hypothetical protein 0.0027 0.003 0.0086
Loa Loa (eye worm) hypothetical protein 0.0251 0.0573 0.162
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0081 0.0081
Mycobacterium tuberculosis Probable lipase LipD 0.015 0.0328 0.1389
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0089 0.0089
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0975
Schistosoma mansoni DNA polymerase eta 0.002 0.0012 0.0075
Schistosoma mansoni zinc finger protein 0.0024 0.0023 0.0139
Schistosoma mansoni importin beta-1 0.0028 0.0034 0.0201
Brugia malayi FAT domain containing protein 0.0109 0.0228 0.0644
Echinococcus granulosus geminin 0.0559 0.1319 0.1743
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Mycobacterium tuberculosis Conserved protein 0.015 0.0328 0.1389
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.033 0.033
Echinococcus granulosus snurportin 1 0.0303 0.0699 0.0923
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0048 0.0081 0.0286
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0089 0.025
Loa Loa (eye worm) latrophilin receptor protein 2 0.008 0.0157 0.0445
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.314 0.7564 0.7564
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.016 1
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0023 0.0066
Plasmodium vivax hypothetical protein, conserved 0.015 0.0328 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0081 0.1142
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0056 0.01 0.0282
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0101 0.0208 0.1245
Schistosoma mansoni hypothetical protein 0.008 0.0157 0.094
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0081 0.1142
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0126 0.0747
Loa Loa (eye worm) MH1 domain-containing protein 0.0101 0.0208 0.0589
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.0479
Onchocerca volvulus 0.015 0.0328 0.1935
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.3084
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.0975
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0568 0.3355
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0048 0.0081 0.0484
Entamoeba histolytica hypothetical protein 0.0141 0.0305 0.2731
Toxoplasma gondii ABC1 family protein 0.015 0.0328 0.4922
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.016 0.4789
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0016 0.0021
Echinococcus multilocularis Zinc finger, PHD finger 0.0048 0.0081 0.0081
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.011 0.0655
Brugia malayi CXXC zinc finger family protein 0.0029 0.0036 0.0102
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0023 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0671 0.396
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0328 0.1935
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0048 0.0081 0.0107
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0328 0.1957
Trichomonas vaginalis PIKK family atypical protein kinase 0.0273 0.0625 0.3692
Leishmania major hypothetical protein, conserved 0.015 0.0328 0.1178
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.003 0.0181
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.016 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0568 0.3355
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0007 0.0007
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0081 0.0229
Schistosoma mansoni ran 0.0021 0.0016 0.0093
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0089 0.0089
Plasmodium vivax hypothetical protein 0.0048 0.0081 0.2321
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0012 0.0112
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Loa Loa (eye worm) hypothetical protein 0.0157 0.0344 0.0972
Onchocerca volvulus 0.0048 0.0081 0.0479
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0048 0.0081 0.0726
Entamoeba histolytica hypothetical protein 0.0476 0.1117 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0178 0.0396 0.234
Plasmodium vivax SET domain protein, putative 0.0091 0.0184 0.5532
Trichomonas vaginalis D-aminoacylase, putative 0.015 0.0328 0.1935
Schistosoma mansoni hypothetical protein 0.0036 0.0053 0.0314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0081 0.0479
Brugia malayi MH2 domain containing protein 0.1477 0.3538 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0072 0.101
Trichomonas vaginalis PIKK family atypical protein kinase 0.031 0.0716 0.423
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.008 0.0157 0.0208
Echinococcus granulosus intermediate filament protein 0.0168 0.0372 0.0491
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.033 0.1972
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0089 0.0529
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0141 0.0305 0.4159
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0023 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0124 0.074
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0036 0.0102
Echinococcus granulosus serine protein kinase ATM 0.0141 0.0305 0.0403
Loa Loa (eye worm) hypothetical protein 0.015 0.0328 0.0926
Echinococcus granulosus Smad4 0.0101 0.0208 0.0276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0081 0.0229
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0023 0.0031
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0048 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.011 0.0428
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0168 0.0372 0.1051
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0081 0.1142
Echinococcus multilocularis tumor protein p63 0.1405 0.3365 0.3365
Onchocerca volvulus 0.0017 0.0007 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0089 0.025
Brugia malayi nuclear receptor NHR-67 0.0024 0.0023 0.0066
Leishmania major hypothetical protein, unknown function 0.0048 0.0081 0.0273
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0184 0.0184
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0081 0.2321
Schistosoma mansoni thyroid hormone receptor 0.0178 0.0396 0.2363
Leishmania major importin beta-1 subunit, putative 0.0023 0.0021 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0089 0.0529
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0012 0.0075
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0048 0.0081 0.0229
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0141 0.0305 0.2731
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0123 0.0446
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.314 0.7564 1
Loa Loa (eye worm) Smad1 0.0101 0.0208 0.0589
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0074 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0023
Leishmania major DNA polymerase kappa, putative 0.002 0.0012 0.0022
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0023
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0336 0.0779 0.2202
Entamoeba histolytica hypothetical protein 0.0048 0.0081 0.0726
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0023 0.0066
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0063 0.0725
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0628 0.1484 0.4194
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0081 0.0229
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0089 0.0529
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0016 0.0044
Trichomonas vaginalis esterase, putative 0.015 0.0328 0.1935
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0023 0.0066
Echinococcus granulosus TGF beta signal transducer SmadC 0.0101 0.0208 0.0276
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0184 0.2723
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0081 0.0273
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.016 0.0589
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0072 0.0096
Brugia malayi beta-lactamase family protein 0.015 0.0328 0.0926
Loa Loa (eye worm) hypothetical protein 0.015 0.0328 0.0926
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0476 0.1117 0.1477
Onchocerca volvulus 0.0024 0.0023 0.0138
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0086
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0034 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0199 0.0447 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0141 0.0305 0.1802
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0074 0.0074
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0081 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0184 0.0184
Brugia malayi MH1 domain containing protein 0.0056 0.01 0.0282
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0016 0.0044
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0048 0.0081 0.0107
Mycobacterium tuberculosis Conserved protein 0.015 0.0328 0.1389
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.015 0.0328 0.0926
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0007 0.0018
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0034 0.0034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0089 0.0089
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0072 0.2052
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0089 0.025
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0007 0.0058
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0101 0.0208 0.0208
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0089 0.0529
Brugia malayi nuclear hormone receptor 0.0051 0.0089 0.025
Schistosoma mansoni cpg binding protein 0.0029 0.0036 0.0216
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0081 0.0107
Mycobacterium ulcerans beta-lactamase 0.015 0.0328 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.0286
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0048 0.0081 0.0286
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.0573 0.162
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0023 0.0066
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0012 0.0022
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0089 0.025
Brugia malayi MH2 domain containing protein 0.0045 0.0074 0.0209
Echinococcus granulosus dnaJ subfamily B 0.0419 0.0978 0.1294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.015 0.0328 0.1389
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0074 0.0209
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.008 0.0157 0.0445
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0089 0.0317
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0048 0.0081 0.0975
Plasmodium falciparum importin beta, putative 0.0028 0.0034 0.177
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0249 0.0568 0.2151
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0007 0.0039
Onchocerca volvulus 0.0206 0.0463 0.2732
Entamoeba histolytica Ran family GTPase 0.0021 0.0016 0.014
Brugia malayi Smad1 0.0101 0.0208 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0051 0.0089 0.025
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0012 0.0023
Trichomonas vaginalis set domain proteins, putative 0.0714 0.1693 1
Schistosoma mansoni smad1 5 8 and 0.0101 0.0208 0.1245
Schistosoma mansoni coup transcription factor 0.0051 0.0089 0.0529
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0671 0.396
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0023 0.0066
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0016 0.0283
Trypanosoma brucei hypothetical protein, conserved 0.015 0.0328 0.4479
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0048 0.0081 0.0484
Brugia malayi ecdysone receptor 0.0024 0.0023 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0093 0.0189 0.1117
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0023 0.0139
Brugia malayi RNA, U transporter 1 0.0081 0.016 0.0453
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0081 0.0484
Schistosoma mansoni smad1 5 8 and 0.0101 0.0208 0.1245
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.008 0.0157 0.0208
Brugia malayi nuclear hormone receptor 0.0024 0.0023 0.0066
Brugia malayi hypothetical protein 0.0052 0.0091 0.0258
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0048 0.0081 0.0107
Brugia malayi hypothetical protein 0.0024 0.0023 0.0066
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0048 0.0081 0.4847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0089 0.025
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0081 0.0484
Entamoeba histolytica hypothetical protein 0.0476 0.1117 1
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0007 0.0058
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0023 0.0023
Loa Loa (eye worm) phosphatidylinositol 3 0.0249 0.0568 0.1606
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.011 0.0145
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.003 0.004
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.031 0.0716 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3624
Loa Loa (eye worm) phosphatidylinositol 3 0.031 0.0716 0.2024
Trichomonas vaginalis penicillin-binding protein, putative 0.015 0.0328 0.1935
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.031 0.0716 0.2718
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0123 0.0446
Schistosoma mansoni hypothetical protein 0.0127 0.0272 0.1626
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0007 0.0018
Echinococcus granulosus lamin 0.0168 0.0372 0.0491
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0081 0.0975
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.2321
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0074 0.0098
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0081 0.0479
Brugia malayi Pre-SET motif family protein 0.0628 0.1484 0.4194
Loa Loa (eye worm) acetyltransferase 0.0151 0.033 0.0933
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0089 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Schistosoma mansoni Smad4 0.0101 0.0208 0.1245
Entamoeba histolytica hypothetical protein 0.0048 0.0081 0.0726
Mycobacterium tuberculosis Probable conserved lipoprotein 0.015 0.0328 0.1389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0202 0.0453 0.2677
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.011 0.1581
Leishmania major DNA polymerase eta, putative 0.002 0.0012 0.0022
Brugia malayi beta-lactamase family protein 0.015 0.0328 0.0926
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Echinococcus multilocularis dna polymerase eta 0.002 0.0012 0.0012
Schistosoma mansoni transcription factor LCR-F1 0.0476 0.1117 0.6672
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0249 0.0568 0.2151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0336 0.0779 0.0779
Toxoplasma gondii FATC domain-containing protein 0.0141 0.0305 0.4576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0089 0.025
Loa Loa (eye worm) hypothetical protein 0.015 0.0328 0.0926
Schistosoma mansoni hypothetical protein 0.0559 0.1319 0.7873
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0081 0.0161 0.0213
Mycobacterium tuberculosis Conserved hypothetical protein 0.0048 0.0081 0.0302
Loa Loa (eye worm) hypothetical protein 0.0109 0.0228 0.0644
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0249 0.0568 0.0568
Trypanosoma cruzi target of rapamycin kinase 3 0.0292 0.0671 0.2544
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0081 0.0479
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0093 0.0189 0.0699
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0023 0.0066
Echinococcus multilocularis thyroid hormone receptor alpha 0.0178 0.0396 0.0396
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0012 0.0035
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.011 0.011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0089 0.0117
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Echinococcus multilocularis GPCR, family 2 0.008 0.0157 0.0157
Echinococcus granulosus GPCR family 2 0.008 0.0157 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0089 0.025
Loa Loa (eye worm) hypothetical protein 0.0078 0.0154 0.0435
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0081 0.0161 0.0161
Onchocerca volvulus 0.0017 0.0007 0.0039
Echinococcus granulosus mothers against decapentaplegic 5 0.0101 0.0208 0.0276
Plasmodium vivax hypothetical protein, conserved 0.0048 0.0081 0.2321
Trichomonas vaginalis conserved hypothetical protein 0.0093 0.0189 0.1117
Onchocerca volvulus 0.0017 0.0007 0.0039
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.015 0.0328 0.0926
Echinococcus multilocularis serine protein kinase ATM 0.0141 0.0305 0.0305
Brugia malayi latrophilin 2 splice variant baaae 0.0172 0.0381 0.1076
Leishmania major cathepsin L-like protease 0.0065 0.0123 0.0427
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0089 0.0117
Schistosoma mansoni Smad4 0.0045 0.0074 0.0441
Entamoeba histolytica hypothetical protein 0.0048 0.0081 0.0726
Trichomonas vaginalis PIKK family atypical protein kinase 0.0292 0.0671 0.396
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0016 0.0035
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0081 0.0479
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.0208 0.0589
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0053 0.007
Schistosoma mansoni hypothetical protein 0.0303 0.0699 0.4171
Loa Loa (eye worm) DR-78 0.0024 0.0023 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.1477 0.3538 1
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0089 0.025
Toxoplasma gondii target of rapamycin (TOR), putative 0.0287 0.0659 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0023 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.031 0.0716 0.423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3623
Loa Loa (eye worm) hypothetical protein 0.015 0.0328 0.0926
Brugia malayi Latrophilin receptor protein 2 0.008 0.0157 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0089 0.025
Loa Loa (eye worm) hypothetical protein 0.0078 0.0154 0.0435
Onchocerca volvulus 0.015 0.0328 0.1935
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0048 0.0081 0.0107
Loa Loa (eye worm) hypothetical protein 0.0093 0.0189 0.0535
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0048 0.0081 0.0479
Brugia malayi Cathepsin L-like precursor 0.0017 0.0007 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0268 0.0614 0.3624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0568 0.3355
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0089 0.0089
Schistosoma mansoni microtubule-associated protein tau 0.0707 0.1675 1
Entamoeba histolytica protein kinase rad3, putative 0.0141 0.0305 0.2731
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Echinococcus granulosus smad 0.0101 0.0208 0.0276
Loa Loa (eye worm) hypothetical protein 0.0045 0.0074 0.0209
Onchocerca volvulus 0.0168 0.0372 0.2195
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0007 0.0039
Loa Loa (eye worm) beta-lactamase 0.015 0.0328 0.0926
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.0779 0.4651
Echinococcus multilocularis Smad4 0.0101 0.0208 0.0208
Plasmodium vivax importin-beta 2, putative 0.0028 0.0034 0.0847
Echinococcus multilocularis cpg binding protein 0.0031 0.004 0.004
Brugia malayi MH1 domain containing protein 0.0101 0.0208 0.0589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0183 0.0408 0.2408
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0089 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.0779 0.4651
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0249 0.0568 0.3392
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0089 0.0523
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0089 0.0529
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0089 0.0089
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0089 0.0089
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0272 0.0272
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0007 0.0018
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0123 0.0446
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0089 0.0529
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0048 0.0081 0.0107
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0726
Brugia malayi Pre-SET motif family protein 0.0091 0.0184 0.0521
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0048 0.0081 0.0286
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0048 0.0081 0.0286
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0081 0.0229
Onchocerca volvulus 0.0048 0.0081 0.0479
Echinococcus multilocularis microtubule associated protein 2 0.0707 0.1675 0.1675
Brugia malayi hypothetical protein 0.0476 0.1117 0.3158
Loa Loa (eye worm) hypothetical protein 0.0048 0.0081 0.0229
Leishmania major GTP-binding protein, putative 0.0021 0.0016 0.0033
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0048 0.0081 0.0726
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Onchocerca volvulus 0.0017 0.0007 0.0039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.015 0.0328 0.1957
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0086
Loa Loa (eye worm) hypothetical protein 0.0091 0.0184 0.0521
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0184 0.11
Schistosoma mansoni cpg binding protein 0.0031 0.004 0.024
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0336 0.0779 0.4651
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0012 0.0023
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.031 0.0716 0.641
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.011 0.3084
Loa Loa (eye worm) hypothetical protein 0.0027 0.003 0.0086
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0007 0.0039
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0048 0.0081 0.1142
Echinococcus granulosus lamin dm0 0.0168 0.0372 0.0491
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.031 0.0716 0.4277
Onchocerca volvulus 0.0017 0.0007 0.0039
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0074 0.0098
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0023 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.0659 0.3892
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0089 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.0249 0.0568 0.3355
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0081 0.0229
Brugia malayi MH1 domain containing protein 0.0101 0.0208 0.0589
Leishmania major cathepsin L-like protease 0.0065 0.0123 0.0427
Brugia malayi nuclear receptor NHR-88 0.0051 0.0089 0.025
Entamoeba histolytica hypothetical protein 0.0048 0.0081 0.0726
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.031 0.0716 0.2024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0184 0.11
Brugia malayi intermediate filament protein 0.0168 0.0372 0.1051
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0048 0.0081 0.0479
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0007 0.0039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0081 0.0229
Echinococcus granulosus dna polymerase eta 0.002 0.0012 0.0017
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0249 0.0568 0.2059
Onchocerca volvulus 0.0714 0.1693 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0023 0.0023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.0699 0.1974
Schistosoma mansoni intermediate filament proteins 0.0168 0.0372 0.2219
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0089 0.025
Brugia malayi MH1 domain containing protein 0.0056 0.01 0.0282
Brugia malayi nuclear receptor NHR-88 0.0024 0.0023 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0081 0.0229
Onchocerca volvulus 0.0017 0.0007 0.0039
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0048 0.0081 0.0081
Schistosoma mansoni hypothetical protein 0.008 0.0157 0.094
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0089 0.0529
Loa Loa (eye worm) hypothetical protein 0.0024 0.0023 0.0066
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0109 0.0228 0.0301
Brugia malayi steroid hormone receptor 0.0051 0.0089 0.025
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0023 0.0066
Echinococcus granulosus histone acetyltransferase KAT2B 0.0147 0.032 0.0423
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0109 0.0394
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0272 0.036
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0048 0.0081 0.0286
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0023 0.0066
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0007 0.0007
Echinococcus granulosus importin subunit beta 1 0.0028 0.0034 0.0045
Loa Loa (eye worm) phosphatidylinositol kinase 0.0048 0.0081 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0123 0.1572
Echinococcus granulosus dna polymerase kappa 0.002 0.0012 0.0017
Onchocerca volvulus 0.0051 0.0089 0.0523
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0081 0.0479
Echinococcus multilocularis cysteine protease 0.0017 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0048 0.0081 0.0286
Leishmania major hypothetical protein, conserved 0.1144 0.2734 1
Mycobacterium leprae Probable lipase LipE 0.015 0.0328 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0157 0.0445
Schistosoma mansoni cpg binding protein 0.0031 0.004 0.024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0089 0.0529
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0089 0.025
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0089 0.025

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 30 uM Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay ChEMBL. 19743863

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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