Detailed information for compound 1063250

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.375 | Formula: C16H15N3S
  • H donors: 1 H acceptors: 2 LogP: 4.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)Nc1scc(n1)Cc1ccncc1
  • InChi: 1S/C16H15N3S/c1-12-3-2-4-14(9-12)18-16-19-15(11-20-16)10-13-5-7-17-8-6-13/h2-9,11H,10H2,1H3,(H,18,19)
  • InChiKey: DWJNLBOVYLDCJE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.007 0.0112 0.3717
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0129 0.0302 0.0277
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0061 0.0082 0.2336
Brugia malayi Cytochrome P450 family protein 0.0061 0.0082 0.0366
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.007 0.0112 0.0341
Entamoeba histolytica hypothetical protein 0.007 0.0112 0.0481
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0198 0.0524 0.3236
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0293 0.0829 0.8712
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0305 0.0869 0.9174
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0129 0.0302 0.0736
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0061 0.0082 0.2336
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0061 0.0082 0.2336
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0039 0.1104
Loa Loa (eye worm) hypothetical protein 0.0316 0.0902 0.4584
Mycobacterium ulcerans hypothetical protein 0.0048 0.0039 0.1104
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Brugia malayi FAT domain containing protein 0.012 0.0273 0.1605
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0327 0.094 0.5935
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0061 0.0082 0.2336
Loa Loa (eye worm) CYP4Cod1 0.0091 0.0179 0.091
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0061 0.0082 0.2336
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0351 0.1015 0.4511
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0091 0.018 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.094 0.5959
Leishmania major hypothetical protein, unknown function 0.007 0.0112 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5465
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0112 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.051 0.3186
Plasmodium vivax hypothetical protein, conserved 0.007 0.0112 0.3717
Loa Loa (eye worm) cytochrome P450 family protein 0.0192 0.0505 0.2568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Giardia lamblia GTOR 0.0327 0.094 0.9694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0207 0.0553 0.3461
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.0197
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0173 0.0442 0.1089
Trypanosoma brucei cytochrome P450, putative 0.0091 0.0179 0.1133
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0829 0.5246
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0327 0.094 0.2593
Onchocerca volvulus 0.007 0.0112 0.1216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.094 0.5959
Leishmania major phosphatidylinositol kinase, putative 0.007 0.0112 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0061 0.0082 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0872 0.5521
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0061 0.0082 0.2336
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.0838 0.8498
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0091 0.0179 0.5108
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0119 0.027 0.0568
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0129 0.0302 0.1724
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0203 0.0539 0.5326
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0305 0.0869 0.232
Schistosoma mansoni hypothetical protein 0.007 0.0112 0.0341
Loa Loa (eye worm) phosphatidylinositol 3 0.0647 0.1968 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.0087 0.0166 0.0357
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0061 0.0082 0.2336
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0203 0.0539 0.3372
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0039 0.1104
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0061 0.0082 0.2336
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0539 0.3274
Entamoeba histolytica hypothetical protein 0.007 0.0112 0.0481
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.007 0.0112 0.0619
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.0112 0.0372
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0522 0.1566 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0306 0.0872 0.5521
Loa Loa (eye worm) phosphatidylinositol 3 0.0327 0.094 0.4777
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0061 0.0082 0.2336
Loa Loa (eye worm) phosphatidylinositol kinase 0.007 0.0112 0.057
Loa Loa (eye worm) hypothetical protein 0.0119 0.027 0.1371
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0327 0.094 0.2593
Brugia malayi Cytochrome P450 family protein 0.0091 0.0179 0.0997
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0083 0.0058
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129 0.0302 0.0665
Schistosoma mansoni fkbp-rapamycin associated protein 0.0173 0.0442 0.1864
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0129 0.0302 0.1843
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0351 0.1015 0.6426
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0351 0.1015 0.0992
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0129 0.0302 0.0277
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0317 0.0906 0.2423
Brugia malayi Cytochrome P450 family protein 0.0192 0.0505 0.3115
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.007 0.0112 0.0619
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0061 0.0082 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.0442 0.2748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0906 0.574
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0061 0.0082 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0197 0.0519 0.3242
Schistosoma mansoni cytochrome P450 0.0061 0.0082 0.0201
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0061 0.0082 0.2336
Loa Loa (eye worm) cytochrome P450 0.0061 0.0082 0.0416
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.007 0.0112 0.0087
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.3142 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.007 0.0112 0.0481
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0112 0.057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0316 0.0902 0.569
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0327 0.094 0.2518
Echinococcus granulosus serine protein kinase ATM 0.019 0.0496 0.0472
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.019 0.0496 0.1252
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0522 0.1566 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0061 0.0082 0.2336
Trypanosoma cruzi cytochrome P450, putative 0.0091 0.0179 0.0294
Leishmania major phosphatidylinositol 4-kinase, putative 0.007 0.0112 0.0205
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0061 0.0082 0.2336
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0144 0.0349 0.2775
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0061 0.0082 0.2336
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0448 0.1329 0.8449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.012 0.0273 0.0248
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Schistosoma mansoni hypothetical protein 0.012 0.0273 0.1082
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0409 0.1203 0.7656
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0061 0.0082 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0146 0.0838
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0173 0.0442 0.0418
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0203 0.0539 0.3372
Mycobacterium leprae conserved hypothetical protein 0.007 0.0112 0.2357
Brugia malayi MH2 domain containing protein 0.0121 0.0274 0.1616
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5466
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0129 0.0302 0.1217
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.019 0.0496 0.3056
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0129 0.0302 0.1535
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.072 0.2204 0.2184
Entamoeba histolytica protein kinase rad3, putative 0.0173 0.0442 0.2642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0061 0.0082 0.2336
Echinococcus granulosus cytochrome P450 2K1 0.0061 0.0082 0.0057
Trypanosoma cruzi cytochrome P450, putative 0.0091 0.0179 0.0294
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.0838 0.5
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0327 0.094 1
Entamoeba histolytica hypothetical protein 0.019 0.0496 0.2996
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0061 0.0082 0.2336
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0173 0.0442 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0906 0.574
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0351 0.1015 0.0992
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.007 0.0112 0.3717
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.051 0.3186
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0061 0.0082 0.2336
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0191 0.0499 0.512
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0316 0.0902 0.0879
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.007 0.0112 0.3717
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0061 0.0082 0.2336
Echinococcus multilocularis microtubule associated protein 2 0.0686 0.2094 0.2073
Trypanosoma cruzi hypothetical protein, conserved 0.1089 0.3391 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0061 0.0082 0.2336
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.0351 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.007 0.0112 0.0092
Schistosoma mansoni hypothetical protein 0.0061 0.0082 0.0201
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0327 0.094 0.0917
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0129 0.0302 0.0277
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0129 0.0302 0.2565
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.007 0.0112 0.0092
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.0112 0.0372
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0083 0.0058
Loa Loa (eye worm) hypothetical protein 0.0038 0.0007 0.0036
Onchocerca volvulus 0.0235 0.0644 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0 0.5
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0522 0.1566 1
Mycobacterium leprae putative cytochrome p450 0.0061 0.0082 0.1385
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.007 0.0112 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0185 0.0482 0.2902
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0061 0.0082 0.2336
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0083 0.0208
Onchocerca volvulus 0.007 0.0112 0.1216
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.0197
Leishmania major phosphatidylinositol 3-kinase, putative 0.0129 0.0302 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0906 0.574
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129 0.0302 0.2699
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.0351 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0061 0.0082 0.2336
Echinococcus multilocularis serine protein kinase ATM 0.019 0.0496 0.0472
Leishmania major hypothetical protein, conserved 0.1159 0.3618 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0061 0.0082 0.2336
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0061 0.0082 0.2336
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0129 0.0302 0.0665
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0061 0.0082 0.2336
Toxoplasma gondii target of rapamycin (TOR), putative 0.0314 0.0897 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0102 0.0216 0.1286
Brugia malayi Cytochrome P450 family protein 0.0091 0.0179 0.0997
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Leishmania major cytochrome p450-like protein 0.0091 0.0179 0.0392
Schistosoma mansoni microtubule-associated protein tau 0.0686 0.2094 0.9489
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0129 0.0302 0.1843
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0061 0.0082 0.2336
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0061 0.0082 0.2336
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0644 0.4048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0083 0.0125
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.007 0.0112 0.0353
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0203 0.0539 0.231
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.007 0.0112 0.0092
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0087 0.0166 0.0255
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.007 0.0112 0.0087
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0039 0.1104
Loa Loa (eye worm) phosphatidylinositol 3 0.0132 0.0312 0.1587
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0061 0.0082 0.2336
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0039 0.0086
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0351 0.1015 0.2821
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0112 0.0563
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0452 0.1339 0.8516
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0112 0.057
Loa Loa (eye worm) cytochrome P450 family protein 0.0091 0.0179 0.091
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0061 0.0082 0.2336
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0083 0.2378
Echinococcus granulosus microtubule associated protein 2 0.0686 0.2094 0.2073
Loa Loa (eye worm) hypothetical protein 0.007 0.0112 0.057
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0039 0.1104
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0061 0.0082 0.2336
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0274 0.1395
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0083 0.2378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0194 0.051 0.3186
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0129 0.0302 1
Loa Loa (eye worm) hypothetical protein 0.0191 0.0499 0.2538
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0061 0.0082 0.0121
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0522 0.1566 0.4485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5466
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0242 0.0665 0.4102
Trichomonas vaginalis conserved hypothetical protein 0.012 0.0273 0.1655
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.007 0.0112 0.0092
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.007 0.0112 0.0372
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0039 0.1104
Entamoeba histolytica hypothetical protein 0.0448 0.1329 0.8449
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0327 0.094 0.59
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0129 0.0302 0.1724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0906 0.574
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0039 0.1104
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0039 0.1104
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0039 0.0086
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0129 0.0302 0.2699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0185 0.0482 0.3004
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0522 0.1566 0.4485
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.019 0.0496 0.4831
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0317 0.0906 0.9605
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0838 0.5231
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.072 0.2204 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5465
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.007 0.0112 0.0087
Trypanosoma cruzi target of rapamycin kinase 3 0.0317 0.0906 0.249
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0216 0.1286
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Loa Loa (eye worm) hypothetical protein 0.0048 0.0039 0.0197
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.012 0.0273 0.0248
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0083 0.2378
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0829 0.5246
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0083 0.0208
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0061 0.0082 0.2336
Plasmodium vivax hypothetical protein 0.007 0.0112 0.3717
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0112 0.0619
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0129 0.0302 1
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.007 0.0112 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0191 0.0499 0.3117
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0039 0.1104
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0061 0.0082 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0869 0.5502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0317 0.0906 0.574
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.007 0.0112 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5466
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0061 0.0082 0.2336
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.019 0.0496 0.2114
Schistosoma mansoni phosphatidylinositol 4-kinase 0.007 0.0112 0.0341
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0327 0.094 0.4162
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0274 0.1395
Echinococcus multilocularis 0.007 0.0112 0.0087
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0327 0.094 0.2518
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.007 0.0112 0.3717
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0203 0.0539 0.1381
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0552 0.2803
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0327 0.094 0.59
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0829 0.5246
Echinococcus multilocularis Zinc finger, PHD finger 0.0129 0.0302 0.0277
Trichomonas vaginalis PIKK family atypical protein kinase 0.0293 0.0829 0.5246
Mycobacterium leprae Conserved hypothetical protein 0.0061 0.0082 0.1385
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0203 0.0539 0.3372
Loa Loa (eye worm) hypothetical protein 0.012 0.0273 0.1386
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0083 0.2378
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0203 0.0539 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.019 0.0496 0.3098
Entamoeba histolytica hypothetical protein 0.007 0.0112 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.0112 0.0619
Echinococcus multilocularis 0.0061 0.0082 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.0838 0.53
Loa Loa (eye worm) hypothetical protein 0.0206 0.055 0.2793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0327 0.094 0.5959
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0522 0.1566 1
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0336 0.0966 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.007 0.0112 0.32
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0061 0.0082 0.2336
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0112 0.0563
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0061 0.0082 0.2336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5466
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0327 0.094 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0576 0.3611
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0351 0.1015 0.2821
Plasmodium falciparum phosphatidylinositol 4-kinase 0.007 0.0112 0.3717
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0409 0.1203 0.7656
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0132 0.0312 0.0696
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.0838 0.5231
Loa Loa (eye worm) hypothetical protein 0.0173 0.0442 0.2247
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.072 0.2204 0.2184
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0173 0.0442 0.2705
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0316 0.0902 0.0879
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0522 0.1566 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.0351 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0129 0.0302 0.1217
Loa Loa (eye worm) cytochrome P450 family protein 0.0091 0.0179 0.091
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.007 0.0112 0.0087
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0129 0.0302 0.1843
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0203 0.0539 0.3332
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0039 0.0086
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0129 0.0302 0.1795
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0039 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0304 0.0863 0.5465
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0061 0.0082 0.2336
Leishmania major cytochrome p450-like protein 0.0061 0.0082 0.0121
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0083 0.0018
Toxoplasma gondii FATC domain-containing protein 0.019 0.0496 0.5083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0897 0.5684
Brugia malayi cytochrome P450 0.0061 0.0082 0.0366
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0327 0.094 0.0917
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0025 0.013
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0061 0.0082 0.2336
Loa Loa (eye worm) phosphatidylinositol 3 0.007 0.0112 0.057
Brugia malayi Pre-SET motif family protein 0.0207 0.0552 0.3415
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.0869 0.4417
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0061 0.0082 0.2336
Leishmania major phosphatidylinositol 3-kinase, putative 0.0293 0.0829 0.2209
Leishmania major cytochrome p450-like protein 0.0061 0.0082 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.007 0.0112 0.0563
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0201 0.0533 0.5262

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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