Detailed information for compound 1073213

Basic information

Technical information
  • TDR Targets ID: 1073213
  • Name: N-(2-methylpropyl)-N-[(3R)-pyrrolidin-3-yl]na phthalene-2-carboxamide
  • MW: 296.407 | Formula: C19H24N2O
  • H donors: 1 H acceptors: 1 LogP: 3.73 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CN(C(=O)c1ccc2c(c1)cccc2)[C@H]1CNCC1)C
  • InChi: 1S/C19H24N2O/c1-14(2)13-21(18-9-10-20-12-18)19(22)17-8-7-15-5-3-4-6-16(15)11-17/h3-8,11,14,18,20H,9-10,12-13H2,1-2H3/t18-/m1/s1
  • InChiKey: CEUJKSVEPJAVKD-GOSISDBHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-isobutyl-N-[(3R)-pyrrolidin-3-yl]naphthalene-2-carboxamide
  • N-isobutyl-N-[(3R)-3-pyrrolidinyl]-2-naphthalenecarboxamide
  • N-isobutyl-N-[(3R)-pyrrolidin-3-yl]-2-naphthamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus dna polymerase eta 0.002 0.0023 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0489 0.2434
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0324 0.1216
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0951 0.2663 0.2663
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0033
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0489 0.0489
Entamoeba histolytica acetyltransferase, GNAT family 0.0085 0.0206 0.4124
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0153 0.0522
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0044 0.0154
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0016 0.0004
Echinococcus multilocularis lamin dm0 0.0029 0.0047 0.0047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0042 0.0105
Leishmania major hypothetical protein, conserved 0.0185 0.0489 0.1829
Brugia malayi Calcitonin receptor-like protein seb-1 0.0315 0.0859 0.3225
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.005 0.0106 0.0106
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0289 0.0832
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.014 0.0379
Schistosoma mansoni lamin 0.0029 0.0047 0.0047
Entamoeba histolytica phosphoglycerate kinase, putative 0.0179 0.0473 1
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0161 0.0161
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0473 0.0473
Schistosoma mansoni hypothetical protein 0.0179 0.0474 0.0474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0091
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0106 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0046 0.0169
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0025 0.0025
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0016 0.0012 0.0043
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0053
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0161 0.0161
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0079 0.0189 0.07
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0047 0.0175
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0481 0.0481
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0025 0.0025
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Plasmodium vivax amine transporter, putative 0.005 0.0106 0.0345
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0045 0.0093 0.0295
Plasmodium falciparum transporter, putative 0.005 0.0106 0.0345
Schistosoma mansoni hypothetical protein 0.0414 0.1138 0.1138
Giardia lamblia Pyruvate kinase 0.0018 0.0016 0.0022
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0108
Brugia malayi acetyltransferase, GNAT family protein 0.0315 0.0858 0.3222
Echinococcus multilocularis transient receptor potential gamma protein 0.0103 0.0257 0.0257
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0106 0.0106
Brugia malayi TAR-binding protein 0.0126 0.0324 0.1217
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0089 0.0323
Echinococcus multilocularis musashi 0.0029 0.0047 0.0047
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0023 0.0077
Brugia malayi CXXC zinc finger family protein 0.0029 0.0048 0.0179
Loa Loa (eye worm) hypothetical protein 0.0292 0.0794 0.2979
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0175
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0078 0.0186 0.0186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0044 0.0154
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0125 0.0416
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0092
Leishmania major pyruvate kinase 0.0034 0.0063 0.0227
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0107 0.0401
Mycobacterium tuberculosis Probable lipase LipE 0.0185 0.0489 0.144
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0044 0.011
Trichomonas vaginalis set domain proteins, putative 0.0718 0.2002 1
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0161 0.0161
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0063 0.0227
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0045 0.0093 0.0237
Echinococcus granulosus lamin dm0 0.0029 0.0047 0.0047
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0009 0.0033
Schistosoma mansoni phosphoglycerate kinase 0.0179 0.0473 0.0473
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0019 0.002 0.0085
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0007 0.0007
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0093 0.0295
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0224 0.0224
Trypanosoma brucei GMP reductase 0.0951 0.2663 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0007 0.0025
Loa Loa (eye worm) hypothetical protein 0.0103 0.0257 0.0965
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0473 0.1758
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0025 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0093 0.0228 0.0806
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0489 0.2434
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0048 0.0101 0.0379
Schistosoma mansoni cellular tumor antigen P53 0.0151 0.0394 0.0394
Brugia malayi RNA, U transporter 1 0.0086 0.021 0.0788
Onchocerca volvulus 0.0038 0.0072 0.0346
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.005 0.0106 0.1621
Plasmodium falciparum phosphoglycerate kinase 0.0179 0.0473 0.1729
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0489 0.1829
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0107 0.0107
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0017
Leishmania major protein kinase, putative 0.0019 0.002 0.0063
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0063 0.0227
Mycobacterium tuberculosis Conserved protein 0.0185 0.0489 0.144
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.0087 0.0087
Brugia malayi beta-lactamase family protein 0.0185 0.0489 0.1837
Echinococcus granulosus smad 0.0043 0.0087 0.0087
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0003 0.0009
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0034 0.0125
Schistosoma mansoni ran 0.0022 0.0029 0.0029
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0276 0.0276
Plasmodium vivax SET domain protein, putative 0.0091 0.0224 0.0789
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0324 0.0324
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.014 0.0472
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Chlamydia trachomatis pyruvate kinase 0.0034 0.0063 0.0948
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0025
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.0087 0.0087
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0023 0.0086
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0024 0.0069
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0531 0.1471 0.552
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.01 0.0248 0.0248
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0067 0.0319
Mycobacterium tuberculosis Possible penicillin-binding protein 0.118 0.3313 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0009 0.0034
Echinococcus granulosus lamin 0.0029 0.0047 0.0047
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0325 0.0941
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Echinococcus multilocularis tumor protein p63 0.1032 0.2893 0.2893
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0066 0.0152 0.0559
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0224 0.0789
Echinococcus multilocularis cpg binding protein 0.0031 0.0053 0.0053
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0079 0.0079
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0289 0.1075
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0044 0.0154
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0063 0.0302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0017
Brugia malayi Phosphoglycerate kinase 0.0179 0.0473 0.1774
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0035
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0035 0.0161
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Brugia malayi MH2 domain containing protein 0.0043 0.0087 0.0327
Loa Loa (eye worm) glutathione reductase 0.005 0.0107 0.0401
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0042 0.0148
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0016
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.002 0.002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.015 0.015
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0489 0.2434
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0044 0.011
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0034 0.0322
Trypanosoma cruzi GMP reductase 0.0951 0.2663 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0029 0.0053
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0023 0.0027
Plasmodium vivax importin-beta 2, putative 0.003 0.0051 0.0139
Onchocerca volvulus 0.0185 0.0489 0.2434
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0181
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0007 0.0007
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0081
Onchocerca volvulus 0.0718 0.2002 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0144 0.0538
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0089 0.0313
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0023 0.0077
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0023 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0325 0.0941
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0007 0.0015
Brugia malayi Smad1 0.0043 0.0087 0.0327
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0063 0.0147
Schistosoma mansoni sodium-dependent amino acid transporter 0.005 0.0106 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Giardia lamblia DINP protein human, muc B family 0.002 0.0023 0.0192
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0185 0.0489 0.1793
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0093 0.0228 0.0806
Echinococcus multilocularis pyruvate kinase 0.0034 0.0063 0.0063
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0024 0.0035
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0063 0.0236
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0125 0.0458
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0343 0.0343
Echinococcus granulosus GPCR family 2 0.01 0.0248 0.0248
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0198 0.0691
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0315 0.086 0.2564
Echinococcus granulosus single minded 2 0.0042 0.0084 0.0084
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.014 0.0472
Loa Loa (eye worm) latrophilin receptor protein 2 0.01 0.0248 0.093
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0179 0.0473 0.1389
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.1264 0.1264
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.002 0.0073
Schistosoma mansoni ran 0.0022 0.0029 0.0029
Leishmania major DNA polymerase kappa, putative 0.002 0.0023 0.0077
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Mycobacterium ulcerans hypothetical protein 0.0315 0.086 0.3192
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.042 0.1157 0.434
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0841 0.3149
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0238 0.0639 0.2391
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0044 0.011
Brugia malayi MH1 domain containing protein 0.0024 0.0033 0.0123
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0025 0.0025
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0481 0.0481
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.0639 0.2358
Loa Loa (eye worm) RNA binding protein 0.0126 0.0324 0.1216
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0325 0.1211
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0178
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.01 0.0248 0.0248
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0063 0.0237
Plasmodium falciparum thioredoxin reductase 0.005 0.0107 0.035
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.0088
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Brugia malayi beta-lactamase 0.0185 0.0489 0.1837
Echinococcus multilocularis beta LACTamase domain containing family member 0.0185 0.0489 0.0489
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.0097
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0035 0.0161
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0343 0.0343
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0951 0.2663 1
Loa Loa (eye worm) MH2 domain-containing protein 0.063 0.1752 0.6577
Loa Loa (eye worm) Smad1 0.0043 0.0087 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0012 0.0012
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0051 0.0173
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0045 0.0093 0.0295
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0296
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0025 0.0025
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0007 0.0007
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0025 0.0025
Brugia malayi Transient-receptor-potential like protein 0.004 0.0079 0.0297
Loa Loa (eye worm) hypothetical protein 0.0042 0.0085 0.0316
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0051 0.0139
Brugia malayi MH2 domain containing protein 0.063 0.1752 0.6578
Echinococcus granulosus ornithine aminotransferase 0.0045 0.0093 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0092
Onchocerca volvulus 0.0029 0.0048 0.0225
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0152 0.0559
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0015 0.0044
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0345
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0481 0.0481
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0044 0.0546
Echinococcus granulosus dna polymerase kappa 0.002 0.0023 0.0023
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0063 0.0184
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.014 0.014
Schistosoma mansoni pyruvate kinase 0.0018 0.0016 0.0016
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0015 0.0059
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0067 0.0319
Schistosoma mansoni lamin 0.0029 0.0047 0.0047
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.014 0.014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0044 0.011
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0093 0.0228 0.1126
Brugia malayi GMP reductase 0.042 0.1157 0.4346
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0087 0.0212 0.0212
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0107 0.035
Echinococcus granulosus transient receptor potential gamma protein 0.0103 0.0257 0.0257
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0015
Echinococcus multilocularis Smad4 0.0043 0.0087 0.0087
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.002 0.0074
Onchocerca volvulus 0.0028 0.0044 0.0205
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0308
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0016
Onchocerca volvulus 0.0185 0.0489 0.2434
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0063 0.0217
Echinococcus multilocularis dna polymerase kappa 0.002 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0091
Echinococcus granulosus peptidase Clp S14 family 0.0156 0.0407 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0025 0.0092
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0181
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0398
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0106 0.0106
Brugia malayi hypothetical protein 0.0109 0.0276 0.1034
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0093 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.01 0.0248 0.0248
Loa Loa (eye worm) nuclear factor I 0.0024 0.0033 0.0122
Loa Loa (eye worm) hypothetical protein 0.0078 0.0186 0.0697
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0016
Brugia malayi Inositol-1 0.0036 0.0067 0.025
Echinococcus granulosus geminin 0.0179 0.0474 0.0474
Schistosoma mansoni Smad4 0.0043 0.0087 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0092
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0106 0.0106
Brugia malayi Thioredoxin reductase 0.005 0.0107 0.0403
Mycobacterium ulcerans hypothetical protein 0.0163 0.0426 0.1555
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.01 0.0248 0.0248
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0107 0.0107
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0186 0.0688
Loa Loa (eye worm) hypothetical protein 0.0179 0.0473 0.1773
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0185 0.0489 0.144
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.007
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0064 0.0228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0182 0.0481 0.0481
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0025 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0185 0.0489 0.1821
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0025 0.0092
Brugia malayi RNA binding protein 0.0126 0.0324 0.1217
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Echinococcus multilocularis Aminotransferase class III 0.0045 0.0093 0.0093
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0045 0.0093 0.0295
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0089 0.0313
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0068
Echinococcus granulosus ubiquitin specific protease 41 0.0078 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0009
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.014 0.014
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0023 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0951 0.2663 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0186 0.0688
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.038 0.1408
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Loa Loa (eye worm) hypothetical protein 0.01 0.0248 0.093
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0045 0.0093 0.0237
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0012 0.0012
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0951 0.2663 1
Loa Loa (eye worm) hypothetical protein 0.0238 0.0639 0.2399
Loa Loa (eye worm) hypothetical protein 0.0185 0.0489 0.1836
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.002 0.002
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.042 0.1157 0.4315
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0063 0.0302
Brugia malayi intermediate filament protein 0.0029 0.0047 0.0176
Brugia malayi ecdysteroid receptor 0.0021 0.0025 0.0092
Brugia malayi Phosphoglycerate kinase 0.0066 0.0152 0.0569
Brugia malayi PAS domain containing protein 0.0051 0.0109 0.0411
Schistosoma mansoni smad 0.0019 0.002 0.002
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0398
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0003 0.0003
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0113 0.0113
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0056 0.02
Echinococcus granulosus pyruvate kinase 0.0034 0.0063 0.0063
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0315 0.0858 0.0858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0145
Schistosoma mansoni DNA polymerase eta 0.002 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0034 0.0062 0.0229
Trypanosoma brucei trypanothione reductase 0.005 0.0107 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0092
Plasmodium falciparum glutathione reductase 0.005 0.0107 0.035
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.024
Mycobacterium leprae conserved hypothetical protein 0.0185 0.0489 0.1829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0224 0.0224
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0185 0.0489 0.144
Echinococcus multilocularis phosphoglycerate kinase 1 0.0179 0.0473 0.0473
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0048 0.0178
Echinococcus granulosus pyruvate kinase 0.0034 0.0063 0.0063
Schistosoma mansoni cpg binding protein 0.0029 0.0048 0.0048
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0016 0.0004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0042 0.0139
Plasmodium falciparum ornithine aminotransferase 0.0045 0.0093 0.0295
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0125 0.0469
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0044 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Giardia lamblia Pyruvate kinase 0.0034 0.0063 0.1061
Toxoplasma gondii hypothetical protein 0.0082 0.0198 0.0691
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.042 0.1157 0.4346
Brugia malayi follicle stimulating hormone receptor 0.0723 0.2015 0.7565
Brugia malayi Probable ClpP-like protease 0.0238 0.0639 0.24
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0088
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0042 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0107 0.0281
Brugia malayi latrophilin 2 splice variant baaae 0.0215 0.0576 0.2163
Trypanosoma brucei unspecified product 0.002 0.0023 0.0068
Echinococcus granulosus tumor protein p63 0.1032 0.2893 0.2893
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0023 0.0068
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0045 0.0093 0.0337
Echinococcus multilocularis dna polymerase eta 0.002 0.0023 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0025 0.0092
Schistosoma mansoni sodium/chloride dependent transporter 0.005 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0025 0.0092
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0182 0.0481 0.1807
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0042 0.0148
Mycobacterium tuberculosis Probable lipase LipD 0.0185 0.0489 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0089 0.0429
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0067 0.0196
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0089 0.0332
Loa Loa (eye worm) GMP reductase 0.042 0.1157 0.4345
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Echinococcus granulosus transient receptor potential ion channel A 0.0097 0.024 0.024
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0161 0.0161
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0089 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0025
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0473 0.1766
Schistosoma mansoni cpg binding protein 0.0031 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Echinococcus granulosus importin subunit beta 1 0.003 0.0051 0.0051
Plasmodium vivax phosphoglycerate kinase, putative 0.0179 0.0473 0.1729
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0125 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0025 0.0025
Trichomonas vaginalis esterase, putative 0.0185 0.0489 0.2434
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0035 0.0161
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.0087 0.0087
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0029 0.0053
Echinococcus granulosus Aminotransferase class III 0.0045 0.0093 0.0093
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0089 0.0333
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0015 0.0059
Giardia lamblia Histone acetyltransferase GCN5 0.0085 0.0206 0.4181
Mycobacterium tuberculosis Probable reductase 0.0114 0.0289 0.0832
Trypanosoma brucei phosphoglycerate kinase, putative 0.0066 0.0152 0.055
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0056 0.0126
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0125 0.0416
Brugia malayi Pre-SET motif family protein 0.0091 0.0224 0.084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0109 0.0109
Schistosoma mansoni importin beta-1 0.003 0.0051 0.0051
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0078 0.0186 0.3739
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Brugia malayi MH1 domain containing protein 0.0043 0.0087 0.0327
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0089 0.0322
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0045 0.0093 0.0237
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0186 0.0186
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.0087 0.0087
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0025 0.0108
Schistosoma mansoni smad1 5 8 and 0.0043 0.0087 0.0087
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0017 0.0042
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.014 0.0472
Mycobacterium ulcerans L-lysine aminotransferase 0.0045 0.0093 0.0295
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0044 0.0154
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0091
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0106 0.0106
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0063 0.0302
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0003 0.0003
Echinococcus multilocularis importin subunit beta 1 0.003 0.0051 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0182 0.0481 0.1808
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0063 0.0302
Echinococcus granulosus phosphoglycerate kinase 1 0.0179 0.0473 0.0473
Brugia malayi hypothetical protein 0.017 0.0449 0.1684
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0044 0.0154
Leishmania major DNA polymerase eta, putative 0.002 0.0023 0.0077
Echinococcus granulosus cpg binding protein 0.0031 0.0053 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0048 0.0226
Leishmania major hypothetical protein, conserved 0.0027 0.0042 0.0148
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0951 0.2663 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0063 0.0237
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0078 0.0186 0.0186
Brugia malayi nuclear hormone receptor 0.0021 0.0025 0.0092
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0029 0.0097
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0029 0.0029
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0473 0.235
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0324 0.1216
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0016 0.0004
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0125 0.0334
Brugia malayi MH1 domain containing protein 0.0024 0.0033 0.0123
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0025 0.0092
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0051
Schistosoma mansoni pyruvate kinase 0.0034 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.01 0.0248 0.0248
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0005
Schistosoma mansoni transient receptor potential channel 0.0069 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.024
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0089 0.0322
Mycobacterium ulcerans lipase LipD 0.0185 0.0489 0.1793
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0011
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0315 0.0859 0.3224
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0024 0.0035
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0047 0.0176
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0025 0.0091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.024
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0072 0.0072
Entamoeba histolytica acyl-coA synthetase, putative 0.0028 0.0044 0.0546
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0179 0.0473 0.1766
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0025 0.0092
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0324 0.1217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0071 0.0339
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0951 0.2663 0.2663
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0276 0.0276
Echinococcus multilocularis lamin 0.0029 0.0047 0.0047
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0315 0.086 0.3222
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0019 0.0017
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0063 0.0184
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.0071
Onchocerca volvulus 0.005 0.0106 0.0516
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0067 0.0067
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0289 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Leishmania major inosine-5-monophosphate dehydrogenase 0.0951 0.2663 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0089 0.0429
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0185 0.0489 0.1837
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0238 0.0639 0.2358
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0078 0.0186 0.0186
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.002 0.002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0224 0.0224
Echinococcus granulosus histone acetyltransferase KAT2B 0.0306 0.0833 0.0833
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0025 0.0025
Treponema pallidum sodium- and chloride- dependent transporter 0.0292 0.0794 1
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0179 0.0473 0.1729
Loa Loa (eye worm) hypothetical protein 0.0034 0.0063 0.0236
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0044 0.0164
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0064 0.0228
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0024 0.0332
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0079 0.0189 0.07
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0158
Mycobacterium ulcerans esterase/lipase LipP 0.0185 0.0489 0.1793
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0025
Echinococcus granulosus tar DNA binding protein 0.0126 0.0324 0.0324
Trypanosoma brucei phosphoglycerate kinase 0.0179 0.0473 0.1758
Toxoplasma gondii hypothetical protein 0.005 0.0106 0.0345
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0025 0.0092
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0951 0.2663 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0003 0.0003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0151 0.0395 0.1481
Schistosoma mansoni transient receptor potential channel 0.0069 0.0161 0.0161
Schistosoma mansoni pyruvate kinase 0.0034 0.0063 0.0063
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0315 0.086 0.4288
Schistosoma mansoni hypothetical protein 0.0215 0.0576 0.0576
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0045 0.0093 0.0337
Plasmodium vivax ornithine aminotransferase, putative 0.0045 0.0093 0.0295
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0015 0.0044
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0089 0.0323
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0042 0.0105
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.8018
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.014 0.014
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0063 0.0236
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0063 0.0217
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.038 0.1416
Schistosoma mansoni peptidase Clp (S14 family) 0.0238 0.0639 0.0639
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0951 0.2663 0.2663
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0044 0.0164
Loa Loa (eye worm) norepinephrine transporter 0.0292 0.0794 0.2979
Brugia malayi hypothetical protein 0.0151 0.0395 0.1482
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.1138 0.1138
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0067 0.0067
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Mycobacterium leprae Probable lipase LipE 0.0185 0.0489 0.1829
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0084 0.0403
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0025 0.0025
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.002 0.0073
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0045 0.0093 0.0093
Trichomonas vaginalis ran, putative 0.0022 0.0029 0.0129
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.005 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Echinococcus multilocularis serotonin transporter 0.0292 0.0794 0.0794
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Onchocerca volvulus 0.0029 0.0047 0.0221
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0025 0.0108
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0186 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0046 0.0213
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.0841 0.3142
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0289 0.0832
Leishmania major importin beta-1 subunit, putative 0.0025 0.0035 0.0121
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0082 0.0198 0.0732
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0107 0.0392
Onchocerca volvulus 0.0185 0.0489 0.2434
Loa Loa (eye worm) acetyltransferase 0.0315 0.0858 0.3221
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0025 0.0108
Toxoplasma gondii IMP dehydrogenas 0.0951 0.2663 1
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0079 0.0079
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0035
Onchocerca volvulus 0.0151 0.0395 0.196
Schistosoma mansoni voltage-gated potassium channel 0.0016 0.0012 0.0012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.0061
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0481 0.0481
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0019 0.0013
Brugia malayi steroid hormone receptor 0.0021 0.0025 0.0092
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0072 0.027
Echinococcus multilocularis geminin 0.0179 0.0474 0.0474
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0315 0.086 0.3192
Echinococcus multilocularis GPCR, family 2 0.01 0.0248 0.0248
Echinococcus granulosus dnaJ subfamily B 0.0414 0.1138 0.1138
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.0101 0.0101
Loa Loa (eye worm) serotonin transporter b 0.0292 0.0794 0.2979
Loa Loa (eye worm) hypothetical protein 0.0215 0.0576 0.2162
Onchocerca volvulus 0.0151 0.0394 0.1956
Brugia malayi MH2 domain containing protein 0.0043 0.0087 0.0327
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0224 0.0224
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0531 0.1471 0.4417
Brugia malayi Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0398
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0951 0.2663 0.8031
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0048 0.0101 0.038
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0072 0.0217
Brugia malayi Importin beta-1 subunit 0.003 0.0051 0.0193
Loa Loa (eye worm) solute carrier family 6 member 4 0.0292 0.0794 0.2979
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0292 0.0794 0.2979
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0023
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0016
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0106 0.0106
Echinococcus granulosus intermediate filament protein 0.0029 0.0047 0.0047
Schistosoma mansoni Smad4 0.0019 0.002 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0044 0.0088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0039 0.0181
Leishmania major phosphoglycerate kinase B, cytosolic 0.0179 0.0473 0.1766
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0023 0.0103
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0068
Echinococcus granulosus Smad4 0.0043 0.0087 0.0087
Echinococcus multilocularis pyruvate kinase 0.0018 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0224 0.0224
Echinococcus multilocularis pyruvate kinase 0.0034 0.0063 0.0063
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.005 0.0106 0.0106
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0024 0.0035
Trichomonas vaginalis D-aminoacylase, putative 0.0185 0.0489 0.2434
Trichomonas vaginalis penicillin-binding protein, putative 0.0185 0.0489 0.2434
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Schistosoma mansoni smad1 5 8 and 0.0043 0.0087 0.0087
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0179 0.0473 0.1729
Trichomonas vaginalis bromodomain-containing protein, putative 0.0093 0.0228 0.1126
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0089 0.0322
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0015 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0023 0.0088
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.017 0.0449 0.1683
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Toxoplasma gondii ABC1 family protein 0.0185 0.0489 0.1793
Onchocerca volvulus 0.0029 0.0047 0.0221
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0345
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.0087 0.0326
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0078 0.0186 0.0915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0154 0.0403 0.0403
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0315 0.0859 0.3225
Toxoplasma gondii hypothetical protein 0.005 0.0106 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Schistosoma mansoni inositol monophosphatase 0.0036 0.0067 0.0067
Onchocerca volvulus 0.0292 0.0794 0.3955
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0015 0.0015
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0106 0.0106
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0292 0.0794 0.0794
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0324 0.0324
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0125 0.0125
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0289 0.0832
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Schistosoma mansoni hypothetical protein 0.0133 0.0343 0.0343
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0114 0.0427
Toxoplasma gondii hypothetical protein 0.005 0.0107 0.0347
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0063 0.0236
Loa Loa (eye worm) beta-lactamase 0.0185 0.0489 0.1836
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0023 0.0023
Onchocerca volvulus 0.0091 0.0224 0.1104
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0631 0.1755 0.6589
Brugia malayi MH2 domain containing protein 0.0019 0.002 0.0074
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0179 0.0473 0.235
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0078 0.0186 0.0688
Mycobacterium ulcerans acetylornithine aminotransferase 0.0045 0.0093 0.0295
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0276 0.0276
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0002 0.0006
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0067 0.0196
Echinococcus multilocularis pyruvate kinase 0.0027 0.0043 0.0043
Plasmodium falciparum importin beta, putative 0.003 0.0051 0.0139
Echinococcus granulosus snurportin 1 0.0323 0.0883 0.0883
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.1264 0.1264
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0064 0.0219
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0156 0.0407 0.119
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0025 0.0092
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0238 0.0639 0.0639
Echinococcus granulosus serotonin transporter 0.0292 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0145
Loa Loa (eye worm) hypothetical protein 0.0151 0.0394 0.1478
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0093 0.0228 0.0806
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0025 0.0025
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0115 0.0423
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.0086
Mycobacterium ulcerans phosphoglycerate kinase 0.0179 0.0473 0.1729
Loa Loa (eye worm) hypothetical protein 0.0021 0.0025 0.0091
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0066 0.0152 0.0559
Giardia lamblia GTOR 0.0043 0.0089 0.1618
Loa Loa (eye worm) hypothetical protein 0.003 0.0051 0.0192
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0089 0.0089
Mycobacterium tuberculosis Conserved protein 0.0185 0.0489 0.144
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.042 0.1157 0.4346
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0025 0.0092
Echinococcus multilocularis peptidase Clp (S14 family) 0.0156 0.0407 0.0407
Brugia malayi hypothetical protein 0.005 0.0106 0.0398
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0067 0.0319
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0224 0.0224
Schistosoma mansoni hypothetical protein 0.0179 0.0474 0.0474
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0015 0.0035
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0089 0.0323
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0015 0.0184
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0021 0.0019
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0089 0.0313
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0057 0.0271
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0323 0.0883 0.3314
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0315 0.0859 0.3224
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0089 0.1536
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0019 0.0017
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.005 0.0106 0.0106
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0067 0.0196
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0078 0.0186 0.0698
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0067 0.105
Brugia malayi nuclear receptor NHR-88 0.0021 0.0025 0.0092
Entamoeba histolytica hypothetical protein 0.0109 0.0276 0.5655
Brugia malayi glutathione reductase 0.005 0.0107 0.0403
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0238 0.0639 0.0639
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0025 0.0092
Schistosoma mansoni voltage-gated potassium channel 0.0052 0.0113 0.0113
Mycobacterium ulcerans hypothetical protein 0.0028 0.0044 0.011
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0951 0.2663 1
Trypanosoma brucei phosphoglycerate kinase 0.0066 0.0152 0.055
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0044 0.0164
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0025 0.0091
Loa Loa (eye worm) inositol-1 0.0036 0.0067 0.0249
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0198 0.2349
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0063 0.0184
Loa Loa (eye worm) hypoxia-induced factor 1 0.0157 0.0411 0.1542
Echinococcus granulosus histone acetyltransferase KAT2B 0.0093 0.0228 0.0228
Echinococcus multilocularis smad 0.0043 0.0087 0.0087
Echinococcus multilocularis sodium and chloride dependent glycine 0.005 0.0106 0.0106
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0079 0.0189 0.07
Mycobacterium tuberculosis Probable esterase LipL 0.0185 0.0489 0.144
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Toxoplasma gondii thioredoxin reductase 0.005 0.0107 0.035
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.0841 0.3149
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Brugia malayi hypoxia-induced factor 1 0.0157 0.0411 0.1544
Onchocerca volvulus Putative GMP reductase 0.042 0.1157 0.5775
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0044 0.0088
Echinococcus granulosus beta LACTamase domain containing family member 0.0185 0.0489 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0186 0.0915
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0089 0.1536
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.0426 0.1249
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0067 0.023
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0015 0.0044
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0015 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0044 0.011
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0015
Loa Loa (eye worm) hypothetical protein 0.0021 0.0024 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0163
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0179 0.0473 0.1766
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0089 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0025 0.0091
Loa Loa (eye worm) hypothetical protein 0.0091 0.0224 0.0839
Plasmodium vivax hypothetical protein, conserved 0.0185 0.0489 0.1793
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0023 0.0077
Leishmania major guanosine monophosphate reductase 0.0951 0.2663 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.014 0.0514
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0002 0.0006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0025 0.0025
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0023 0.0027
Mycobacterium ulcerans hypothetical protein 0.0185 0.0489 0.1793
Schistosoma mansoni coup transcription factor 0.0021 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0292 0.0794 0.2979
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0063 0.0302
Onchocerca volvulus 0.005 0.0106 0.0516
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0397
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Chlamydia trachomatis phosphoglycerate kinase 0.0179 0.0473 0.7383
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0025 0.0025
Plasmodium vivax hypothetical protein, conserved 0.005 0.0106 0.0345
Onchocerca volvulus 0.005 0.0106 0.0516
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0198 0.0691
Schistosoma mansoni single-minded 0.0051 0.0109 0.0109
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.0061
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0045 0.0093 0.0337
Loa Loa (eye worm) hypothetical protein 0.0024 0.0034 0.0125
Mycobacterium tuberculosis Conserved protein 0.0185 0.0489 0.144
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0125 0.0125
Brugia malayi Latrophilin receptor protein 2 0.01 0.0248 0.0931
Loa Loa (eye worm) IMP dehydrogenase 1 0.0951 0.2663 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0025 0.0091
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.005 0.0106 0.0398
Echinococcus granulosus uncharacterized sodium dependent transporter 0.005 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0323 0.0883 0.0883
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0057 0.0161
Schistosoma mansoni Smad4 0.0019 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0292 0.0794 0.2979
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.005 0.0106 0.0106
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0012 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0403 0.0403
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0025 0.0025
Plasmodium falciparum pyruvate kinase 0.0034 0.0063 0.0184
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0007 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Brugia malayi beta-lactamase family protein 0.0185 0.0489 0.1837
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0051 0.0173
Echinococcus granulosus sodium and chloride dependent glycine 0.005 0.0106 0.0106
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0025 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0007 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0038 0.0178
Schistosoma mansoni thyroid hormone receptor 0.0154 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0024 0.0033 0.0122
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0045 0.0093 0.0237
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0951 0.2663 1
Brugia malayi hypothetical protein 0.0018 0.0015 0.0057
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0025 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.038 0.1416
Trypanosoma cruzi hypothetical protein, conserved 0.0185 0.0489 0.1829
Giardia lamblia Phosphoglycerate kinase 0.0179 0.0473 1
Mycobacterium ulcerans beta-lactamase 0.0185 0.0489 0.1793
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.1264 0.1264
Brugia malayi hypothetical protein 0.0027 0.0042 0.0159
Echinococcus multilocularis transient receptor potential ion channel A 0.0097 0.024 0.024
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0078 0.0186 0.0679
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0093 0.0093
Trypanosoma cruzi GMP reductase 0.0951 0.2663 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0106 0.0397
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0185 0.0489 0.1836
Schistosoma mansoni transient receptor potential channel 4 0.0103 0.0257 0.0257
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0951 0.2663 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0063 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0064 0.0303
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0032 0.0146
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0029 0.0029
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0078 0.0186 0.3678
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0019 0.0057
Entamoeba histolytica hypothetical protein 0.0025 0.0035 0.0355
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0238 0.0639 0.2358
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0163
Brugia malayi MH1 domain containing protein 0.0043 0.0087 0.0327
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0186 0.0186
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0019 0.0097
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0078 0.0186 0.0186
Leishmania major phosphoglycerate kinase C, glycosomal 0.0179 0.0473 0.1766
Mycobacterium tuberculosis Probable aminotransferase 0.0315 0.086 0.2564
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0045 0.0093 0.0295
Schistosoma mansoni inositol monophosphatase 0.0036 0.0067 0.0067
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0179 0.0473 0.1729
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0182 0.0481 0.0481
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.0101 0.0101
Onchocerca volvulus 0.0021 0.0025 0.0108
Echinococcus multilocularis ubiquitin specific protease 41 0.0078 0.0186 0.0186
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0089 0.0089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.01 0.0248 0.0931
Leishmania major pyruvate kinase 0.0034 0.0063 0.0227
Echinococcus granulosus neuropeptide s receptor 0.0458 0.1264 0.1264
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0012 0.0012
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0044 0.011
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0015 0.0044
Schistosoma mansoni sodium/chloride dependent transporter 0.0292 0.0794 0.0794
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0025 0.0025
Schistosoma mansoni transient receptor potential channel 0.0103 0.0257 0.0257
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0025 0.0025
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0045 0.0093 0.0348
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.005 0.0106 0.0106
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Loa Loa (eye worm) transcription factor SMAD2 0.063 0.1752 0.6577
Echinococcus granulosus pyruvate kinase 0.0018 0.0016 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0042 0.0105
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0289 0.0832
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0007 0.0005
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.005 0.0106 0.0397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0089 0.0429
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0156 0.0407 0.1519
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0723 0.2015 0.7565
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0185 0.0489 0.0489
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0015 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Entamoeba histolytica Ran family GTPase 0.0022 0.0029 0.0213
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0015 0.0055
Leishmania major trypanothione reductase 0.005 0.0107 0.0392
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0019
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0024 0.0028
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0185 0.0489 0.144
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0156 0.0407 0.119
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0023 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0182 0.0481 0.0481
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0023 0.0033
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0007 0.0024
Schistosoma mansoni smad1 5 8 and 0.0043 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0109 0.0276 0.0276
Plasmodium falciparum amino acid transporter, putative 0.005 0.0106 0.0345
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.014 0.0472
Schistosoma mansoni intermediate filament proteins 0.0029 0.0047 0.0047
Schistosoma mansoni smad 0.0043 0.0087 0.0087
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0003 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.0087 0.0326
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.005 0.0106 0.0106
Leishmania major GTP-binding protein, putative 0.0022 0.0029 0.0097
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0047 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0025 0.0092
Treponema pallidum phosphoglycerate kinase 0.0179 0.0473 0.588
Echinococcus multilocularis snurportin 1 0.0323 0.0883 0.0883
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Mycobacterium tuberculosis Probable hydrolase 0.0185 0.0489 0.144
Entamoeba histolytica acyl-CoA synthetase, putative 0.0028 0.0044 0.0546
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0325 0.0941
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.0081
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0315 0.0858 0.0858
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0023 0.0023
Plasmodium falciparum histone acetyltransferase GCN5 0.0085 0.0206 0.0723
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0042
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0045 0.0093 0.1411
Loa Loa (eye worm) hypothetical protein 0.0028 0.0044 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0023 0.0068
Plasmodium vivax glutathione reductase, putative 0.005 0.0107 0.035
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.005 0.0106 0.0106
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0238 0.0639 0.2358
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.002 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0025 0.0025
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.0841 0.3149
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0029 0.0053
Brugia malayi Pre-SET motif family protein 0.0631 0.1755 0.659
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0023 0.0103

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5 nM Inhibition of serotonin reuptake at human serotonin transporter expressed in HEK293 cells after 5 mins by scintillation counting ChEMBL. 19740658
IC50 (binding) = 1.2 uM Inhibition of noradrenaline reuptake at human noradrenaline transporter expressed in HEK293 cells after 15 mins by scintillation counting ChEMBL. 19740658
IC50 (binding) = 9.5 uM Inhibition of dopamine reuptake at human dopamine transporter expressed in HEK293 cells after 5 mins by scintillation counting ChEMBL. 19740658
Ki (binding) = 7 uM Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells ChEMBL. 19740658

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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