Detailed information for compound 1083178

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 619.518 | Formula: C30H26F9NO3
  • H donors: 0 H acceptors: 1 LogP: 8.73 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1c1ccc(cc1CN1C(=O)O[C@@H]([C@@H]1C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F)C(C)C
  • InChi: 1S/C30H26F9NO3/c1-15(2)17-5-8-25(42-4)24(12-17)23-7-6-20(28(31,32)33)11-19(23)14-40-16(3)26(43-27(40)41)18-9-21(29(34,35)36)13-22(10-18)30(37,38)39/h5-13,15-16,26H,14H2,1-4H3/t16-,26-/m0/s1
  • InChiKey: ZLMDMGVNLQHTAU-QMTYFTJSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholesteryl ester transfer protein, plasma Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0001 0.0003
Brugia malayi GnHR receptor homolog 0.0009 0.0001 0.0002
Trichomonas vaginalis ran, putative 0.0024 0.0065 0.0506
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0043 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0103 0.0131
Loa Loa (eye worm) hypothetical protein 0.0074 0.028 0.0687
Schistosoma mansoni hypothetical protein 0.0049 0.0171 0.0543
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0167 0.0491
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0036 0.0089
Onchocerca volvulus 0.0054 0.0192 0.1806
Trypanosoma brucei trypanothione reductase 0.0041 0.0137 0.3185
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0103 0.0327
Schistosoma mansoni amine GPCR 0.0009 0.0001 0.0003
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0054 0.0192 0.4612
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0116 0.1085
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0001 0.0001
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0022 0.0185
Echinococcus multilocularis microtubule associated protein 2 0.0745 0.3155 0.3997
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0103 0.0253
Echinococcus granulosus nibrin 0.0012 0.0012 0.0036
Entamoeba histolytica Ran family GTPase 0.0024 0.0065 0.0689
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0103 0.0327
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0177 0.0224
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.1344
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0111 0.0099
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni amine GPCR 0.0009 0.0001 0.0003
Schistosoma mansoni amine GPCR 0.0009 0.0001 0.0003
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0179 0.0526
Onchocerca volvulus 0.0041 0.0136 0.1273
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0103 0.0253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0183 0.0748 0.0727
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0001 0.0003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0022 0.0054
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0177 0.2257
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0103 0.013
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0012 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0183 0.0748 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0001 0.0003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0405 0.0384
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0043 0.0297
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0006 0.0015
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0183 0.0748 0.0736
Brugia malayi MAP kinase sur-1 0.005 0.0177 0.0432
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0116 0.2695
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0041 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0103 0.0253
Leishmania major 4-coumarate:coa ligase-like protein 0.0183 0.0748 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Leishmania major acetyl-CoA synthetase, putative 0.0054 0.0192 0.247
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0043 0.0021
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0054 0.0192 0.0171
Onchocerca volvulus 0.0041 0.0136 0.1273
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0116 0.1085
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0361 0.0339
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0103 0.0253
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0054 0.0192 0.018
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0041 0.0136 0.0333
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.028 0.0268
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0051 0.0179 0.0439
Loa Loa (eye worm) hypothetical protein 0.0074 0.028 0.0687
Brugia malayi nuclear receptor NHR-88 0.0033 0.0103 0.0253
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0065 0.0989
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0115 0.0981
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0001 0.0003
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0001 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0169 0.0687 0.2017
Entamoeba histolytica hypothetical protein 0.0191 0.0782 1
Echinococcus granulosus g protein coupled receptor 0.0009 0.0001 0.0003
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0001 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.028 0.0889
Echinococcus multilocularis neuropeptide receptor A26 0.0517 0.218 0.2761
Onchocerca volvulus 0.0041 0.0136 0.1273
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0403 1
Brugia malayi Importin beta-1 subunit 0.0033 0.0103 0.0251
Echinococcus multilocularis geminin 0.0675 0.2857 0.3619
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0001 0.0003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0103 0.0327
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0028 0.0083
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0534 0.0676
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0001 0.0001
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0179 0.0439
Treponema pallidum bacterioferrin (TpF1) 0.002 0.0045 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0471
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0022 0.0254
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0111 0.0099
Schistosoma mansoni acetyl-CoA synthetase 0.0054 0.0192 0.0609
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0001 0.0001
Onchocerca volvulus 0.0183 0.0748 0.7044
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0534 0.1692
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0103 0.0091
Schistosoma mansoni lamin 0.0026 0.0074 0.0234
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.0527 0.129
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0022 0.3019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0054 0.0192 0.0471
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0033
Onchocerca volvulus 0.0016 0.0028 0.0259
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0137 0.0115
Echinococcus multilocularis cpg binding protein 0.0035 0.0112 0.0142
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0192 0.0171
Brugia malayi neuropeptide F receptor 0.0009 0.0001 0.0002
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0012 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0369 0.0467
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0103 0.0253
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.002 0.0045 0.0033
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0183 0.0748 0.0736
Onchocerca volvulus 0.0074 0.028 0.2637
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0001 0.0003
Echinococcus granulosus neuropeptide receptor 0.0009 0.0001 0.0003
Echinococcus multilocularis somatostatin receptor 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0104 0.0406 0.0994
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.028 0.0259
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Onchocerca volvulus 0.0074 0.028 0.2637
Schistosoma mansoni transcription factor LCR-F1 0.0191 0.0782 0.248
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.016 0.0138
Loa Loa (eye worm) DR-78 0.0016 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.1344
Entamoeba histolytica protein kinase, putative 0.0091 0.0354 0.4433
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0116 0.1085
Brugia malayi Serotonin receptor 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0043 0.0031
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0675 0.2857 0.9055
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0198 0.0582
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0012 0.0000025933
Echinococcus multilocularis pyruvate kinase 0.0036 0.0116 0.0147
Brugia malayi beta-lactamase 0.0074 0.028 0.0687
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0103 0.0253
Plasmodium vivax acyl-CoA synthetase, putative 0.0137 0.0549 1
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.0136 0.0333
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0022 0.0185
Mycobacterium ulcerans bacterioferritin BfrA 0.002 0.0045 0.0033
Schistosoma mansoni ferritin 0.002 0.0045 0.0143
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0028 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0177 0.1567
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0001 0.0002
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.028 0.0355
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0028 0.0069
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0011 0.0026
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0534 0.1692
Chlamydia trachomatis pyruvate kinase 0.0036 0.0116 0.1932
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.002 0.0045 0.0023
Loa Loa (eye worm) RNA binding protein 0.0133 0.0534 0.1307
Echinococcus multilocularis protein dispatched 1 0.0058 0.021 0.0266
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0169 0.0415
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.0799
Schistosoma mansoni microtubule-associated protein tau 0.0745 0.3155 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0103 0.0327
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1061 1
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0103 0.0327
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0177 0.1567
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0074 0.0181
Plasmodium falciparum importin beta, putative 0.0033 0.0103 0.1683
Schistosoma mansoni intermediate filament proteins 0.0026 0.0074 0.0234
Echinococcus multilocularis nibrin 0.0012 0.0012 0.0015
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0001 0.0003
Brugia malayi DKFZp564C0469 protein 0.0012 0.0012 0.003
Schistosoma mansoni neuropeptide receptor 0.0009 0.0001 0.0003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0022 0.007
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0065 0.0083
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0061 0.015
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0369 0.0903
Brugia malayi ecdysteroid receptor 0.0033 0.0103 0.0253
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0022 0.0163
Echinococcus multilocularis lamin dm0 0.0026 0.0074 0.0093
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0103 0.0131
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0028 0.0036
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0103 0.0965
Entamoeba histolytica acyl-coA synthetase, putative 0.0183 0.0748 0.9547
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus allatostatin A receptor 0.0009 0.0001 0.0003
Brugia malayi Muscleblind-like protein 0.0145 0.0583 0.1429
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0183 0.0748 0.0727
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0028 0.0036
Entamoeba histolytica hypothetical protein 0.0191 0.0782 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0036 0.0225
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0116 0.2655
Leishmania major trypanothione reductase 0.0041 0.0137 0.1715
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0116 0.0284
Schistosoma mansoni hypothetical protein 0.0298 0.1241 0.3934
Schistosoma mansoni nuclear receptor 0.0016 0.0028 0.009
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0534 0.1692
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0001 0.0003
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.0354 0.8753
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0001 0.0003
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0115 0.0338
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0103 0.0303
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.015
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0167 0.0491
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0002 0.0006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.0581
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0001 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0069 0.0169
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0054
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0403 0.5068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0103 0.0326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0307
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0054 0.0192 0.4612
Echinococcus multilocularis Niemann Pick C1 protein 0.0118 0.0469 0.0594
Loa Loa (eye worm) hypothetical protein 0.0036 0.0116 0.0284
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0803 0.3404 0.8338
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0001 0.0002
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0041 0.0531
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0074 0.0181
Onchocerca volvulus 0.0041 0.0136 0.1273
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2674
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0001 0.0003
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.0176
Mycobacterium ulcerans acetyl-CoA synthetase 0.0054 0.0192 0.018
Trichomonas vaginalis esterase, putative 0.0074 0.028 0.2557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0103 0.0253
Onchocerca volvulus 0.0026 0.0074 0.0688
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0116 0.0104
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0028 0.009
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0103 0.2313
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0177 0.424
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0369 0.1083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0076 0.0607
Brugia malayi hypothetical protein 0.0012 0.0012 0.003
Leishmania major acetyl-CoA synthetase, putative 0.0054 0.0192 0.247
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0103 0.0303
Brugia malayi G-protein coupled receptor 0.0009 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.0517 0.0496
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.015
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0167 0.0212
Echinococcus granulosus ferritin 0.002 0.0045 0.0133
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0198 0.0628
Echinococcus granulosus fmrfamide receptor 0.0009 0.0001 0.0003
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0138
Brugia malayi hypothetical protein 0.0191 0.0782 0.1916
Brugia malayi intermediate filament protein 0.0026 0.0074 0.0181
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0012 0.0054
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0103 0.0303
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0115 0.0365
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0169 0.0537
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0074 0.028 0.0687
Echinococcus granulosus serotonin receptor 0.0009 0.0001 0.0003
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0177 0.0164
Entamoeba histolytica protein kinase domain containing protein 0.0091 0.0354 0.4433
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0001 0.0001
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0251
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0001 0.0003
Brugia malayi sulfakinin receptor protein 0.0009 0.0001 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.028 0.0889
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Brugia malayi Dopamine receptor protein 2 0.0009 0.0001 0.0002
Mycobacterium ulcerans beta-lactamase 0.0074 0.028 0.0268
Loa Loa (eye worm) hypothetical protein 0.0145 0.0583 0.1429
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0177 0.4209
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0116 0.0284
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0022 0.0053
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0069 0.0739
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0103 0.0131
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0001 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0254
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0103 0.0253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0089
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.0517 0.0496
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0036 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0369 0.1168
Brugia malayi RE15519p 0.0009 0.0001 0.0002
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0078 0.0191
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.028 0.0268
Echinococcus granulosus neuropeptide receptor A26 0.0517 0.218 0.6403
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0028 0.009
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0167 0.0212
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0001 0.0001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0103 0.0403 0.5322
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0103 0.0131
Echinococcus multilocularis muscleblind protein 1 0.0145 0.0583 0.0739
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0001 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) MBCTL1 0.0055 0.0198 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0307
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0054 0.0192 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0268 0.0851
Echinococcus granulosus pyruvate kinase 0.0036 0.0116 0.034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0069 0.0169
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0091 0.0354 0.4658
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Plasmodium vivax importin-beta 2, putative 0.0033 0.0103 0.1683
Onchocerca volvulus 0.0033 0.0103 0.0961
Toxoplasma gondii pantoate-beta-alanine ligase 0.2341 1 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.009 0.0348 0.0853
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0001 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.028 0.6869
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.028 0.6886
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0076 0.1675
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0103 0.0131
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0028 0.009
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0028 0.009
Brugia malayi hypothetical protein 0.0018 0.0037 0.009
Loa Loa (eye worm) hypothetical protein 0.0012 0.0014 0.0033
Onchocerca volvulus 0.0023 0.0061 0.0571
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Schistosoma mansoni hypothetical protein 0.0012 0.0014 0.0044
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0111 0.2569
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0177 0.2257
Plasmodium falciparum thioredoxin reductase 0.0014 0.0022 0.0185
Onchocerca volvulus 0.0054 0.0192 0.1806
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0006 0.0015
Trichomonas vaginalis ferritin, putative 0.002 0.0045 0.0314
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0116 0.0988
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0181
Mycobacterium tuberculosis Bacterioferritin BfrB 0.002 0.0045 0.0023
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0001 0.0001
Echinococcus granulosus importin subunit beta 1 0.0033 0.0103 0.0301
Schistosoma mansoni hypothetical protein 0.0049 0.0171 0.0543
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0001 0.0003
Plasmodium falciparum acyl-CoA synthetase 0.0137 0.0549 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0961 0.4083 1
Schistosoma mansoni apoferritin-2 0.002 0.0045 0.0143
Trypanosoma cruzi polo-like protein kinase, putative 0.0103 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0369 0.0903
Brugia malayi nuclear receptor RXR 0.0016 0.0028 0.0069
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0001 0.0002
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.028 0.0259
Echinococcus granulosus pyruvate kinase 0.0018 0.0041 0.012
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0115 0.0282
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0116 0.1932
Onchocerca volvulus 0.0023 0.0061 0.0571
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0038
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0028 0.0069
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0405 0.0384
Schistosoma mansoni pyruvate kinase 0.0036 0.0116 0.0367
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0169 0.0214
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0054 0.0192 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.0183 0.0748 0.0736
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0043 0.0849
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0095 0.0278
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0022 0.0307
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0022 0.001
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0065 0.016
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.009 0.0348 0.0853
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0103 0.0253
Leishmania major importin beta-1 subunit, putative 0.0027 0.0076 0.0892
Brugia malayi LBP/BPI 0.0017 0.0036 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0179 0.0227
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0103 0.0303
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0065 0.016
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0061 0.015
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0103 0.0965
Brugia malayi Melatonin receptor type 1A 0.0009 0.0001 0.0002
Echinococcus multilocularis musashi 0.0026 0.0074 0.0093
Schistosoma mansoni hypothetical protein 0.0048 0.0167 0.053
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0028 0.0036
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0001 0.0001
Brugia malayi AMP-binding enzyme family protein 0.0183 0.0748 0.1831
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0001 0.0002
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0028 0.0083
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0103 0.0131
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0001 0.0003
Schistosoma mansoni importin beta-1 0.0033 0.0103 0.0325
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0001 0.0003
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0137 0.0549 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0369 0.1168
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0001 0.0003
Echinococcus granulosus tar DNA binding protein 0.0133 0.0534 0.1568
Loa Loa (eye worm) hypothetical protein 0.0062 0.0228 0.0559
Echinococcus granulosus sex peptide receptor 0.0009 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0192 0.0471
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0115 0.0981
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0022 0.0163
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0036 0.0089
Entamoeba histolytica hypothetical protein 0.0191 0.0782 1
Echinococcus multilocularis snurportin 1 0.0351 0.1467 0.1859
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0001 0.0003
Echinococcus granulosus neuropeptide receptor 0.0009 0.0001 0.0003
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0116 0.2655
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0022 0.001
Plasmodium vivax hypothetical protein, conserved 0.0074 0.028 0.4997
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.0928 0.2272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0022 0.0307
Onchocerca volvulus 0.0054 0.0192 0.1806
Mycobacterium ulcerans acyl-CoA synthetase 0.0183 0.0748 0.0736
Echinococcus multilocularis dual specificity 0.0091 0.0354 0.0448
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0103 0.0327
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0534 0.1307
Loa Loa (eye worm) hypothetical protein 0.0172 0.07 0.1714
Echinococcus granulosus g protein coupled receptor 0.0009 0.0001 0.0003
Echinococcus multilocularis survival motor neuron protein 1 0.0803 0.3404 0.4312
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0028 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0103 0.0253
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0179 0.0526
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0003
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0001 0.0002
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0043 0.0128
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0028 0.0083
Echinococcus granulosus pyruvate kinase 0.0018 0.0041 0.012
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0078 0.1228
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0028 0.0036
Mycobacterium ulcerans hypothetical protein 0.0183 0.0748 0.0736
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0103 0.0327
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0036 0.0046
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0091 0.0354 0.0866
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0403 0.051
Schistosoma mansoni hypothetical protein 0.0351 0.1467 0.465
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0088
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0028 0.0069
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0361 0.0339
Schistosoma mansoni ferritin light chain 0.002 0.0045 0.0143
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0111 0.0272
Brugia malayi glutathione reductase 0.0041 0.0137 0.0334
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0116 0.0284
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0036 0.0089
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.1344
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0167 0.041
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0139 0.0176
Onchocerca volvulus 0.0033 0.0104 0.0971
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0054 0.0192 0.0244
Schistosoma mansoni ran 0.0024 0.0065 0.0207
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0065 0.1359
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0054 0.0192 0.0171
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0028 0.0259
Brugia malayi CHE-14 protein 0.0051 0.0179 0.0439
Onchocerca volvulus 0.0054 0.0192 0.1806
Entamoeba histolytica protein kinase, putative 0.0091 0.0354 0.4433
Schistosoma mansoni neuropeptide receptor 0.0009 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0103 0.0253
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.028 0.0259
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0027 0.0076 0.0826
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0307
Schistosoma mansoni niemann-pick C1 (NPC1) 0.012 0.0477 0.1511
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0078 0.1734
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0198 0.0251
Echinococcus granulosus Niemann Pick C1 protein 0.0118 0.0469 0.1377
Echinococcus multilocularis muscleblind protein 0.0145 0.0583 0.0739
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0177 0.4209
Brugia malayi hypothetical protein 0.0023 0.0061 0.015
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0403 0.0986
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0001 0.0003
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0164 0.0664 0.1625
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0177 0.0224
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0361 0.0339
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0405 0.0384
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0192 0.0471
Schistosoma mansoni biogenic amine receptor 0.0009 0.0001 0.0003
Echinococcus granulosus hypothetical protein 0.0009 0.0001 0.0003
Entamoeba histolytica hypothetical protein 0.0191 0.0782 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0001 0.0002
Echinococcus granulosus intermediate filament protein 0.0026 0.0074 0.0217
Echinococcus granulosus somatostatin receptor 0.0009 0.0001 0.0003
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0054 0.0192 0.018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0001 0.0003
Echinococcus multilocularis ferritin 0.002 0.0045 0.0057
Schistosoma mansoni ferritin light chain 0.002 0.0045 0.0143
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0111 0.0326
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0001 0.0001
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0028 0.0069
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.0192 0.018
Leishmania major hypothetical protein, conserved 0.0027 0.0078 0.0923
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0022 0.0095
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni nuclear receptor 0.0016 0.0028 0.009
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0001 0.0002
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0116 0.2695
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0014 0.0022 0.3019
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0028 0.0069
Treponema pallidum NADH oxidase 0.0014 0.0022 0.3019
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0103 0.0327
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0012 0.0000002723
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0361 0.0339
Loa Loa (eye worm) hypothetical protein 0.0183 0.0748 0.1831
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0054 0.0192 0.018
Plasmodium vivax SET domain protein, putative 0.0033 0.0103 0.1687
Echinococcus multilocularis sex peptide receptor 0.0009 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0183 0.0748 0.0736
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0028 0.0069
Onchocerca volvulus 0.0033 0.0103 0.0965
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0103 0.0965
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0103 0.0253
Schistosoma mansoni coup transcription factor 0.0033 0.0103 0.0327
Brugia malayi Niemann-Pick C1 protein precursor 0.0118 0.0469 0.1148
Brugia malayi AMP-binding enzyme family protein 0.0183 0.0748 0.1831
Echinococcus multilocularis lamin 0.0026 0.0074 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0116 0.0284
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0054 0.0192 0.0471
Schistosoma mansoni hypothetical protein 0.0049 0.0171 0.0543
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0103 0.0303
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis expressed conserved protein 0.0111 0.0438 0.0555
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0022 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0043 0.0405
Loa Loa (eye worm) glutathione reductase 0.0041 0.0137 0.0334
Toxoplasma gondii propionate-CoA ligase 0.0054 0.0192 0.018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Brugia malayi mbt repeat family protein 0.0048 0.0169 0.0415
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0012 0.0054
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.015
Loa Loa (eye worm) hypothetical protein 0.0145 0.0583 0.1429
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0192 0.0471
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0043 0.0799
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0012 0.0054
Schistosoma mansoni ferritin 0.002 0.0045 0.0143
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0116 0.0104
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.1467 0.3593
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0103 0.0326
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0011 0.0031
Mycobacterium tuberculosis Conserved protein 0.0074 0.028 0.0259
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0054 0.0192 0.4642
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0054 0.0192 0.4642
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Echinococcus multilocularis pyruvate kinase 0.0036 0.0116 0.0147
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0115 0.0146
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0111 0.2529
Trichomonas vaginalis conserved hypothetical protein 0.0167 0.068 0.6366
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0022 0.0185
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0001 0.0002
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0198 0.0251
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0195 0.0797 0.101
Toxoplasma gondii exonuclease III APE 0.0019 0.0043 0.0031
Echinococcus granulosus pyruvate kinase 0.0018 0.0041 0.012
Brugia malayi Augmenter of liver regeneration 0.0035 0.0111 0.0272
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0028 0.0259
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0137 0.0549 0.0537
Echinococcus granulosus microtubule associated protein 2 0.0745 0.3155 0.9269
Brugia malayi Dopamine receptor 0.0009 0.0001 0.0002
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0076 0.0607
Trypanosoma brucei polo-like protein kinase 0.0103 0.0403 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0169 0.1589
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0006
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0074 0.0181
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0254
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0405 0.0394
Brugia malayi hypothetical protein 0.0017 0.0036 0.0089
Brugia malayi ORL1-like opioid receptor 0.0009 0.0001 0.0002
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0116 0.0988
Schistosoma mansoni cpg binding protein 0.0035 0.0112 0.0355
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0028 0.0083
Schistosoma mansoni apoferritin-2 0.002 0.0045 0.0143
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0103 0.0253
Brugia malayi nuclear receptor NHR-67 0.0016 0.0028 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0307
Echinococcus granulosus survival motor neuron protein 1 0.0803 0.3404 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0054 0.0192 0.0471
Onchocerca volvulus 0.0041 0.0136 0.1273
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0169 0.0497
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0177 0.0519
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Schistosoma mansoni ran 0.0024 0.0065 0.0207
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0065 0.0192
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0167 0.041
Brugia malayi beta-lactamase family protein 0.0074 0.028 0.0687
Brugia malayi ecdysone receptor 0.0016 0.0028 0.0069
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0104 0.0254
Brugia malayi neuropeptide F receptor 0.0009 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0089
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0043 0.0452
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0534 0.1307
Echinococcus granulosus snurportin 1 0.0351 0.1467 0.431
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0001 0.0003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0022 0.0254
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0001 0.0001
Echinococcus multilocularis GPCR, family 2 0.0048 0.0167 0.0212
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Schistosoma mansoni adenoreceptor 0.0009 0.0001 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0103 0.0327
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0103 0.009
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0065 0.1359
Schistosoma mansoni hypothetical protein 0.0048 0.0167 0.053
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.028 0.0259
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0036 0.0115
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni DNA ligase IV 0.0012 0.0012 0.0039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0369 0.1168
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0089
Mycobacterium tuberculosis Probable reductase 0.0093 0.0361 0.0339
Trypanosoma brucei protein kinase, putative 0.005 0.0177 0.4209
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0043 0.9483
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0041 0.0136 0.0333
Echinococcus multilocularis Niemann Pick C1 protein 0.0169 0.0687 0.087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0088
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0048 0.0169 0.0415
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0001 0.0001
Mycobacterium ulcerans lipase LipD 0.0074 0.028 0.0268
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0054 0.0192 0.0171
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0001 0.0003
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0078 0.1689
Loa Loa (eye worm) hypothetical protein 0.0048 0.0167 0.041
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.185 0.7894 1
Schistosoma mansoni hypothetical protein 0.0164 0.0664 0.2103
Echinococcus multilocularis pyruvate kinase 0.0028 0.0083 0.0106
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0183 0.0748 0.0736
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0612 0.1498
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0022 0.0095
Plasmodium falciparum glutathione reductase 0.0014 0.0022 0.0185
Echinococcus granulosus dual specificity 0.0091 0.0354 0.1039
Schistosoma mansoni neuropeptide receptor 0.0009 0.0001 0.0003
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Brugia malayi AMP-binding enzyme family protein 0.0054 0.0192 0.0471
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0198 0.0582
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0043 0.0297
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0043 0.0055
Loa Loa (eye worm) hypothetical protein 0.0074 0.028 0.0687
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0118 0.0469 0.5929
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0179 0.1593
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0137 0.3222
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0103 0.0327
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2634
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Loa Loa (eye worm) hypothetical protein 0.0183 0.0748 0.1831
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0103 0.0326
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Brugia malayi hypothetical protein 0.0016 0.0028 0.0069
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0091 0.0354 0.8753
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0191 0.0782 0.2299
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.0527 0.129
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0177 0.1567
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0169 0.0214
Echinococcus multilocularis pyruvate kinase 0.0018 0.0041 0.0052
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0054 0.0192 0.0171
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0115 0.0365
Echinococcus granulosus muscleblind protein 0.0145 0.0583 0.1714
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0534 0.1692
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0177 0.0519
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0022 0.001
Schistosoma mansoni opsin-like receptor 0.0009 0.0001 0.0003
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0054 0.0192 0.0171
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.028 0.0824
Plasmodium falciparum glutathione reductase 0.0041 0.0137 0.2317
Brugia malayi putative neuropeptide receptor 0.0009 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0103 0.0253
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0001 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0103 0.0326
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0065 0.1406
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0012 0.0000025933
Schistosoma mansoni hypothetical protein 0.0048 0.0167 0.053
Mycobacterium tuberculosis Conserved protein 0.0074 0.028 0.0259
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0116 0.0094
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0043 0.9483
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0091 0.0354 0.8746
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0103 0.0131
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0103 0.0303
Schistosoma mansoni hypothetical protein 0.0048 0.0167 0.053
Echinococcus granulosus GPCR family 2 0.0048 0.0167 0.0491
Echinococcus granulosus tachykinin peptides receptor 99D 0.0009 0.0001 0.0003
Brugia malayi hypothetical protein 0.0017 0.0036 0.0088
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0022 0.0307
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0036 0.0115
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.028 0.0259
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0103 0.0253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0103 0.0253
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0001 0.0003
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0001 0.0003
Echinococcus multilocularis serotonin receptor 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0192 0.0171
Plasmodium vivax acetyl-CoA synthetase, putative 0.0054 0.0192 0.3355
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0054 0.0192 0.018
Mycobacterium tuberculosis Conserved protein 0.0074 0.028 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0177 0.0559
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0065 0.0989
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0116 0.0104
Brugia malayi AKH receptor 0.0009 0.0001 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.028 0.0259
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0169 0.0497
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0115 0.2674
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0172 0.07 0.1714
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Brugia malayi conserved hypotetical protein 0.0016 0.0028 0.0069
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0089
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0182 0.1617
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.028 0.0259
Echinococcus granulosus orexin receptor type 2 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0074 0.028 0.0687
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0012 0.0000035309
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0028 0.0083
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0078 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0103 0.0253
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0001 0.0003
Brugia malayi follicle stimulating hormone receptor 0.0961 0.4083 1
Brugia malayi larval opioid receptor 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0183 0.0748 0.1831
Loa Loa (eye worm) oxidoreductase 0.0054 0.0192 0.0471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0022 0.001
Schistosoma mansoni histamine h1 receptor 0.0009 0.0001 0.0003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0104 0.0406 0.1287
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0103 0.0253
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0111 0.184
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0001 0.0001
Brugia malayi G protein-coupled receptor 0.0009 0.0001 0.0002
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0115 0.1423
Schistosoma mansoni hypothetical protein 0.0473 0.1988 0.6302
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.0517 0.0496
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0001 0.0001
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0054 0.0192 0.0171
Brugia malayi CXXC zinc finger family protein 0.0033 0.0104 0.0254
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0014 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Plasmodium vivax glutathione reductase, putative 0.0041 0.0137 0.2317
Mycobacterium leprae conserved hypothetical protein 0.0074 0.028 0.0268
Loa Loa (eye worm) hypothetical protein 0.0055 0.0198 0.0485
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0403 0.379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Schistosoma mansoni ferritin 0.002 0.0045 0.0143
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0198 0.0485
Schistosoma mansoni opsin-like receptor 0.0009 0.0001 0.0003
Plasmodium falciparum pyruvate kinase 0.0036 0.0116 0.1932
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0054 0.0192 0.018
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0001 0.0003
Schistosoma mansoni myosin xvIII 0.0009 0.0001 0.0003
Schistosoma mansoni zinc finger protein 0.0016 0.0028 0.009
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.0192 0.018
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0115 0.2634
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.2341 1 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0054 0.0192 0.018
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.028 0.2557
Schistosoma mansoni ap endonuclease 0.0019 0.0043 0.0138
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0103 0.0303
Echinococcus granulosus expressed protein 0.002 0.0045 0.0133
Schistosoma mansoni amine GPCR 0.0009 0.0001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0103 0.0253
Echinococcus granulosus geminin 0.0675 0.2857 0.8393
Brugia malayi hypothetical protein 0.0012 0.0012 0.003
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0103 0.0327
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0012 0.0039
Giardia lamblia Pyruvate kinase 0.0036 0.0116 0.2655
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.0192 0.018
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0054 0.0192 0.4642
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0001 0.0002
Brugia malayi topoisomerase 0.0012 0.0012 0.003
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0091 0.0354 0.4433
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0475 0.1999 0.1981
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0078 0.1734
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0103 0.0131
Schistosoma mansoni biogenic amine receptor 0.0009 0.0001 0.0003
Brugia malayi MH2 domain containing protein 0.0132 0.0527 0.129
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0137 0.0334
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0169 0.0537
Echinococcus granulosus neuropeptide s receptor 0.0517 0.218 0.6403
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0061 0.015
Echinococcus granulosus pyruvate kinase 0.0036 0.0116 0.034
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0103 0.013
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0803 0.3404 0.8338
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0182 0.1617
Brugia malayi Protein kinase domain containing protein 0.0091 0.0354 0.0866
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0008 0.002
Schistosoma mansoni hypothetical protein 0.0049 0.0171 0.0543
Loa Loa (eye worm) hypothetical protein 0.0118 0.0469 0.1148
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0054 0.0192 0.0471
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.0354 0.1121
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0111 0.184
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0001 0.0003
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0167 0.041
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0115 0.0338
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0043 0.0849
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0001 0.0001
Schistosoma mansoni topbp1 0.0012 0.0012 0.0039
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi RNA, U transporter 1 0.0094 0.0363 0.0888
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0103 0.0253
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0089
Schistosoma mansoni patched 1 0.0051 0.0179 0.0568
Schistosoma mansoni kinase 0.0053 0.0188 0.0595
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0361 0.0339
Schistosoma mansoni cpg binding protein 0.0033 0.0104 0.0329
Schistosoma mansoni hypothetical protein 0.0675 0.2857 0.9055
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0003
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0177 0.424
Echinococcus multilocularis pyruvate kinase 0.0018 0.0041 0.0052
Leishmania major pyruvate kinase 0.0036 0.0116 0.1434
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0111 0.2569
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0001 0.0001
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0001 0.0001
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0361 0.0349
Echinococcus multilocularis protein patched 0.0051 0.0179 0.0227
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0022 0.0053
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0183 0.0748 0.0736
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0137 0.2317
Trichomonas vaginalis antibiotic synthetase, putative 0.0054 0.0192 0.1717
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0054 0.0192 0.018
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0065 0.1406
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0403 0.0986
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0183 0.0748 0.0736
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0115 0.0282
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0612 0.1498
Schistosoma mansoni opsin-like receptor 0.0009 0.0001 0.0003
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.001 0.0025
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0001 0.0001
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0054 0.0192 0.0565
Brugia malayi RNA binding protein 0.0133 0.0534 0.1307
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0001 0.0002
Brugia malayi Thioredoxin reductase 0.0041 0.0137 0.0334
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0022 0.0185
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0163
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0001 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0001 0.0003
Schistosoma mansoni pyruvate kinase 0.0036 0.0116 0.0367
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0534 0.1692
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.028 0.2557
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0111 0.2569
Trichomonas vaginalis antibiotic synthetase, putative 0.0054 0.0192 0.1717
Schistosoma mansoni topbp1 0.0012 0.0012 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0103 0.0253
Echinococcus granulosus lamin dm0 0.0026 0.0074 0.0217
Onchocerca volvulus 0.0026 0.0074 0.0688
Brugia malayi hypothetical protein 0.0016 0.0028 0.0069
Onchocerca volvulus 0.0041 0.0136 0.1273
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0177 0.0432
Schistosoma mansoni pyruvate kinase 0.0018 0.0041 0.0129
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0183 0.0748 0.9547
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0001 0.0003
Onchocerca volvulus 0.0041 0.0136 0.1273
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.015
Brugia malayi hypothetical protein 0.0023 0.0061 0.015
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0028 0.0083
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0115 0.0146
Brugia malayi Pre-SET motif family protein 0.0033 0.0103 0.0252
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0307
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0169 0.0537
Leishmania major GTP-binding protein, putative 0.0024 0.0065 0.0748
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0136 0.0333
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0012 0.0000025933
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0103 0.0303
Leishmania major pyruvate kinase 0.0036 0.0116 0.1434
Schistosoma mansoni hypothetical protein 0.0191 0.0782 0.248
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0001 0.0001
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0177 0.424
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.1344
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0054 0.0192 0.018
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.028 0.2557
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0009 0.0001 0.0003
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0111 0.0141
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.002 0.0045 1
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0001 0.0002
Onchocerca volvulus 0.0016 0.0028 0.0259
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0236 0.0224
Echinococcus multilocularis expressed protein 0.002 0.0045 0.0057
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0043 0.0106
Loa Loa (eye worm) hypothetical protein 0.0137 0.0549 0.1344
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0022 0.0065
Toxoplasma gondii thioredoxin reductase 0.0041 0.0137 0.0124
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0054 0.0192 0.0471
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0028 0.0036
Brugia malayi nuclear receptor RXR 0.0017 0.0036 0.0089
Onchocerca volvulus 0.0164 0.0664 0.6253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0192 0.0171
Brugia malayi G-protein coupled receptor 0.0009 0.0001 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.028 0.2557
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0191 0.0782 0.0991
Brugia malayi TAR-binding protein 0.0133 0.0534 0.1307
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0017 0.0036 0.0088
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0041 0.0136 0.0333
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0014 0.0041
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0054 0.0192 0.018
Brugia malayi Serotonin receptor 0.0009 0.0001 0.0002
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0534 0.1307
Schistosoma mansoni biogenic amine receptor 0.0009 0.0001 0.0003
Schistosoma mansoni ferritin 0.002 0.0045 0.0143
Mycobacterium ulcerans bacterioferritin BfrB 0.002 0.0045 0.0033
Brugia malayi nuclear hormone receptor 0.0033 0.0103 0.0253
Echinococcus granulosus expressed conserved protein 0.0111 0.0438 0.1287
Mycobacterium leprae Probable lipase LipE 0.0074 0.028 0.0268
Schistosoma mansoni neuropeptide receptor 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Brugia malayi Pre-SET motif family protein 0.0225 0.0928 0.2272
Loa Loa (eye worm) hypothetical protein 0.0074 0.028 0.0687
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0103 0.0253
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0028 0.0036
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0054 0.0192 0.2338
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0001 0.0003
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0137 0.0549 0.0528
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0103 0.0302
Giardia lamblia Pyruvate kinase 0.0018 0.0041 0.073
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0116 0.0284
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0078 0.1228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0023 0.0061 0.015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0001 0.0003
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0001 0.0003
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.028 0.0687
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0054 0.0192 0.247
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0054 0.0192 0.0171
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.028 0.2557
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0139 0.0408
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0017 0.0036 0.0089
Onchocerca volvulus 0.0074 0.028 0.2637
Onchocerca volvulus 0.0041 0.0136 0.1273
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0022 0.0254
Onchocerca volvulus 0.0256 0.1061 1
Brugia malayi tailless protein 0.0016 0.0028 0.0069
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0054 0.0192 0.4642
Toxoplasma gondii ABC1 family protein 0.0074 0.028 0.0268
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0103 0.2313
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0001 0.0002
Echinococcus granulosus cpg binding protein 0.0035 0.0112 0.0329
Brugia malayi steroid hormone receptor 0.0033 0.0103 0.0253
Giardia lamblia Kinase, PLK 0.0103 0.0403 1
Plasmodium falciparum thioredoxin reductase 0.0041 0.0137 0.2317
Leishmania major hypothetical protein, conserved 0.0035 0.0111 0.1367
Echinococcus granulosus lamin 0.0026 0.0074 0.0217
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0369 0.0467
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0103 0.0303
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0001 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0115 0.0981
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0103 0.013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0129 0.0517 0.0496
Echinococcus granulosus g protein coupled receptor 0.0009 0.0001 0.0003
Onchocerca volvulus 0.0012 0.0012 0.0107
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0016 0.0046
Echinococcus multilocularis serotonin receptor 0.0009 0.0001 0.0001
Brugia malayi hypothetical protein 0.0027 0.0078 0.0191
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0177 0.424
Schistosoma mansoni lamin 0.0026 0.0074 0.0234
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0103 0.0253
Schistosoma mansoni amine GPCR 0.0009 0.0001 0.0003
Brugia malayi nuclear hormone receptor 0.0016 0.0028 0.0069
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0115 0.1335
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0001 0.0001
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0043 0.0581
Echinococcus granulosus dnaJ subfamily B 0.0473 0.1988 0.5841
Schistosoma mansoni survival motor neuron protein 0.0164 0.0664 0.2103
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0001 0.0002
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.028 0.0687
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0001 0.0001
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0177 0.1567
Onchocerca volvulus 0.0017 0.0036 0.033
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Brugia malayi hypothetical protein 0.0009 0.0001 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0369 0.1083
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0253
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0403 0.1276
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.028 0.6886
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0612 0.1498
Loa Loa (eye worm) hypothetical protein 0.0016 0.0028 0.0069
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0115 0.0338
Leishmania major 4-coumarate:coa ligase-like protein 0.0183 0.0748 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0022 0.0307
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0192 0.0171
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0183 0.0748 0.9547
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0001 0.0002
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0054 0.0192 0.3355
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0001 0.0003
Brugia malayi mbt repeat family protein 0.0048 0.0169 0.0415
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0014 0.0022 0.0185
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.2341 1 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0076 0.0607
Brugia malayi Dopamine receptor protein 1 0.0009 0.0001 0.0002
Onchocerca volvulus 0.0048 0.0169 0.1589
Schistosoma mansoni cpg binding protein 0.0035 0.0112 0.0355
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0195 0.0797 0.2341
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0103 0.0253
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0023 0.0061 0.015
Echinococcus multilocularis dnaJ subfamily B 0.0473 0.1988 0.2519
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0002 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Brugia malayi AMP-binding enzyme family protein 0.0183 0.0748 0.1831
Brugia malayi nuclear receptor NHR-88 0.0016 0.0028 0.0069
Echinococcus multilocularis pyruvate kinase 0.0018 0.0041 0.0052
Loa Loa (eye worm) beta-lactamase 0.0074 0.028 0.0687
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0078 0.1228
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0183 0.0748 0.0736
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0406 0.0994
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0115 0.0146
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0065 0.0053
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0103 0.0131
Leishmania major hypothetical protein, conserved 0.0074 0.028 0.3665
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0403 0.3722
Loa Loa (eye worm) hypothetical protein 0.0009 0.0001 0.0002
Echinococcus multilocularis neuropeptide s receptor 0.0517 0.218 0.2761
Loa Loa (eye worm) hypothetical protein 0.0152 0.0612 0.1498
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0103 0.0252
Brugia malayi beta-lactamase family protein 0.0074 0.028 0.0687
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0403 0.1183
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0041 0.0531
Mycobacterium ulcerans hypothetical protein 0.0074 0.028 0.0268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0001 0.0001

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 22 mg/dl Increase in HDL-cholesterol level in C57BL/6 mouse expressing cynomolgus monkey CETP gene assessed as change in HDL-C level at 10 mg/kg, po BID measured 24 hrs after first dose ChEMBL. 21682257
IC50 (binding) = 15.2 nM Inhibition of human recombinant CETP-mediated cholesteryl ester transfer activity after 1 hr by fluorescent cholesteryl esters transfer assay ChEMBL. 21682257
Inhibition (binding) = 94 % Inhibition of human recombinant CETP-mediated cholesteryl ester transfer activity at 100 uM after 1 hr by fluorescent cholesteryl esters transfer assay relative to control ChEMBL. 21682257

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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