Detailed information for compound 108370

Basic information

Technical information
  • TDR Targets ID: 108370
  • Name: 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-py ridin-3-ylethenyl]quinoline-3-carbonitrile
  • MW: 447.316 | Formula: C24H16Cl2N4O
  • H donors: 1 H acceptors: 3 LogP: 6.43 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1cnc2c(c1Nc1cc(OC)c(cc1Cl)Cl)ccc(c2)/C=C/c1cccnc1
  • InChi: 1S/C24H16Cl2N4O/c1-31-23-11-22(19(25)10-20(23)26)30-24-17(12-27)14-29-21-9-15(6-7-18(21)24)4-5-16-3-2-8-28-13-16/h2-11,13-14H,1H3,(H,29,30)/b5-4+
  • InChiKey: GJRVKJRPFCCZKA-SNAWJCMRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,4-dichloro-5-methoxy-anilino)-7-[(E)-2-(3-pyridyl)vinyl]quinoline-3-carbonitrile
  • 4-(2,4-dichloro-5-methoxyanilino)-7-[(E)-2-(3-pyridyl)vinyl]-3-quinolinecarbonitrile
  • 4-[(2,4-dichloro-5-methoxy-phenyl)amino]-7-[(E)-2-pyridin-3-ylethenyl]quinoline-3-carbonitrile
  • 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[(E)-2-pyridin-3-ylethenyl]quinoline-3-carbonitrile
  • 4-[(2,4-dichloro-5-methoxy-phenyl)amino]-7-[(E)-2-(3-pyridyl)vinyl]quinoline-3-carbonitrile
  • 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-[(E)-2-(3-pyridyl)vinyl]-3-quinolinecarbonitrile
  • 3-quinolinecarbonitrile deriv. 19

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0212 0.0452 0.0604
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0074 0.1179
Brugia malayi Transient-receptor-potential like protein 0.0043 0.0014 0.002
Echinococcus granulosus tissue type plasminogen activator 0.0073 0.0092 0.0122
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0031 0.0041
Schistosoma mansoni heat shock protein 0.0139 0.0264 0.0286
Trypanosoma cruzi heat shock protein 90, putative 0.0139 0.0264 0.301
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0092 0.1029
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0043 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0194 0.0408 0.0441
Schistosoma mansoni growth hormone secretagogue receptor 0.0212 0.0452 0.0489
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0149 0.029 0.0388
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0117 0.0207 0.1836
Giardia lamblia Beta tubulin 0.0066 0.0074 0.1493
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0114 0.0153
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) ion channel NompC 0.0043 0.0014 0.002
Echinococcus multilocularis sex peptide receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.0377 0.0408
Loa Loa (eye worm) glutathione reductase 0.0098 0.0156 0.0227
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0082 0.0114 0.0753
Echinococcus multilocularis g-protein coupled receptor 0.0212 0.0452 0.0604
Toxoplasma gondii microneme protein MIC17A 0.0115 0.0201 0.0414
Echinococcus multilocularis GPCR, family 2 0.0679 0.1666 0.2225
Echinococcus multilocularis tubulin subunit beta 0.0066 0.0074 0.0099
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0014 0.0018
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0074 0.0107
Echinococcus granulosus neuropeptide receptor A26 0.1267 0.3191 0.4261
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0105 0.0174 0.0253
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0003 0.0004
Brugia malayi nuclear receptor NHR-67 0.0038 0.0003 0.0004
Echinococcus granulosus voltage gated hydrogen channel 1 0.0043 0.0014 0.0018
Echinococcus granulosus somatostatin receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0059 0.0055 0.0091
Plasmodium vivax glutathione reductase, putative 0.0098 0.0156 0.3222
Schistosoma mansoni hypothetical protein 0.0059 0.0055 0.0059
Brugia malayi G protein-coupled receptor F59B2.13 0.0212 0.0452 0.0656
Schistosoma mansoni vesicular amine transporter 0.0043 0.0014 0.0015
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0097 0.0154 0.0206
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0043 0.0014 0.0018
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.008
Echinococcus granulosus zinc finger protein Ran binding 0.0059 0.0055 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0584 1
Brugia malayi nuclear receptor NHR-88 0.0082 0.0114 0.0166
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0043 0.0014 0.0139
Schistosoma mansoni voltage-gated ion channel 0.0043 0.0014 0.0015
Loa Loa (eye worm) TYRA-2 protein 0.0212 0.0452 0.0656
Brugia malayi hypothetical protein 0.0038 0.0003 0.0004
Schistosoma mansoni jun-related protein 0.0079 0.0107 0.0116
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0212 0.0452 0.0604
Brugia malayi Steroid receptor seven-up type 2 0.0082 0.0114 0.0166
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0212 0.0452 0.0656
Plasmodium falciparum thioredoxin reductase 0.0098 0.0156 0.4648
Echinococcus granulosus adenylate cyclase 9 0.0062 0.0063 0.0084
Schistosoma mansoni biogenic amine receptor 0.0212 0.0452 0.0489
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0014 0.0015
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0014 0.0015
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Brugia malayi Caveolin-1 0.0514 0.1238 0.1796
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0059 0.0055 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) bone morphogenic protein 6 0.013 0.024 0.0348
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0059 0.0055 0.0608
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0212 0.0452 0.0604
Onchocerca volvulus 0.0076 0.01 0.0661
Echinococcus multilocularis hyperpolarization activated cyclic 0.0043 0.0014 0.0018
Echinococcus multilocularis voltage dependent calcium channel 0.0149 0.029 0.0388
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0043 0.0014 0.0018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0003 0.0004
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0444 0.1054 0.27
Onchocerca volvulus 0.0059 0.0055 0.0361
Loa Loa (eye worm) PAN domain-containing protein 0.0115 0.0201 0.0292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0114 0.0166
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0212 0.0452 0.0656
Schistosoma mansoni Replicative DNA helicase 0.0444 0.1054 0.114
Loa Loa (eye worm) hypothetical protein 0.0149 0.029 0.0422
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0003 0.0004
Echinococcus granulosus FTZ F1 alpha 0.0082 0.0114 0.0153
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Loa Loa (eye worm) hypothetical protein 0.0679 0.1666 0.2417
Brugia malayi Serotonin receptor 0.0212 0.0452 0.0656
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.014 0.0266 0.0355
Trypanosoma cruzi heat shock protein 85, putative 0.0139 0.0264 0.301
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0183 0.0377 0.0547
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0149 0.029 0.0422
Schistosoma mansoni amine GPCR 0.0212 0.0452 0.0489
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0043 0.0014 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0212 0.0452 0.0604
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0117 0.0207 0.2355
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0014 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus multilocularis conserved hypothetical protein 0.0043 0.0014 0.0018
Onchocerca volvulus 0.0115 0.0201 0.1326
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0043 0.0014 0.002
Echinococcus granulosus neuropeptide FF receptor 2 0.0212 0.0452 0.0604
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0015 0.0016
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0014 0.0015
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0043 0.0014 0.0018
Echinococcus multilocularis heat shock protein 0.0139 0.0264 0.0353
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0073 0.0092 0.069
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Schistosoma mansoni hypothetical protein 0.0679 0.1666 0.1802
Echinococcus granulosus calcium activated potassium channel 0.0044 0.0018 0.0025
Brugia malayi phosphoinositide-dependent protein kinase I 0.0105 0.0174 0.0253
Onchocerca volvulus Neuropeptide F receptor homolog 0.0212 0.0452 0.2975
Trypanosoma cruzi heat shock protein 90, putative 0.0113 0.0196 0.2222
Brugia malayi Dopamine receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0149 0.029 0.0388
Echinococcus multilocularis short transient receptor potential channel 6 0.0043 0.0014 0.0018
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Brugia malayi putative neuropeptide receptor NPR1 0.0212 0.0452 0.0656
Onchocerca volvulus 0.0212 0.0452 0.2975
Trypanosoma brucei beta tubulin 0.0066 0.0074 0.0826
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.0021 0.0028
Echinococcus multilocularis hyperpolarization activated cyclic 0.0043 0.0014 0.0018
Schistosoma mansoni fusion 0.0059 0.0055 0.0059
Loa Loa (eye worm) tubulin beta-4 chain 0.0066 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0043 0.0014 0.002
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0095 0.0151 0.0163
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0212 0.0452 0.0489
Trypanosoma cruzi heat shock protein 85, putative 0.0139 0.0264 0.301
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0003 0.0018
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0149 0.029 0.0314
Toxoplasma gondii transporter, cation channel family protein 0.0149 0.029 0.0611
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0171 0.0346 0.2275
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0149 0.029 0.0388
Brugia malayi ecdysteroid receptor 0.0082 0.0114 0.0166
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0014 0.0018
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) TK/ROR protein kinase 0.0074 0.0095 0.0138
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.0021 0.0028
Brugia malayi putative neuropeptide receptor 0.0212 0.0452 0.0656
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0117 0.0207 0.1836
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Brugia malayi glutathione reductase 0.0098 0.0156 0.0227
Echinococcus granulosus biogenic amine 5HT receptor 0.0212 0.0452 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0082 0.0114 0.0166
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0092 0.0133
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0043 0.0014 0.002
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0149 0.029 0.0388
Echinococcus granulosus fmrfamide receptor 0.0212 0.0452 0.0604
Toxoplasma gondii PAN/Apple domain-containing protein 0.0115 0.0201 0.0414
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0043 0.0014 0.002
Loa Loa (eye worm) TK protein kinase 0.0041 0.0009 0.0014
Echinococcus granulosus hypothetical protein 0.0212 0.0452 0.0604
Plasmodium falciparum glutathione reductase 0.0098 0.0156 0.4648
Loa Loa (eye worm) PAN domain-containing protein 0.0115 0.0201 0.0292
Echinococcus multilocularis neuroendocrine convertase 2 0.009 0.0136 0.0181
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0049 0.0031 0.0041
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0055 0.0608
Toxoplasma gondii PAN domain-containing protein 0.0115 0.0201 0.0414
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0114 0.0166
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0043 0.0014 0.0015
Echinococcus granulosus hypothetical protein 0.0043 0.0014 0.0018
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0212 0.0452 0.0604
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0374 0.6366
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Brugia malayi Thioredoxin reductase 0.0098 0.0156 0.0227
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0117 0.0207 0.1836
Trichomonas vaginalis tubulin gamma chain, putative 0.0066 0.0074 0.1179
Brugia malayi YY1-associated factor 2 0.0059 0.0055 0.008
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0043 0.0014 0.002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0031 0.0041
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0049 0.0031 0.0041
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0212 0.0452 0.0604
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0082 0.0114 0.0166
Echinococcus granulosus tm gpcr rhodopsin 0.0212 0.0452 0.0604
Onchocerca volvulus 0.0043 0.0014 0.0091
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus multilocularis neuropeptide receptor A26 0.1267 0.3191 0.4261
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Brugia malayi bZIP transcription factor family protein 0.0097 0.0154 0.0224
Echinococcus multilocularis two pore calcium channel protein 2 0.0043 0.0014 0.0018
Toxoplasma gondii PAN domain-containing protein 0.0115 0.0201 0.0414
Brugia malayi Adenylyl cyclase protein 0.0062 0.0063 0.0091
Trypanosoma cruzi beta tubulin, putative 0.0066 0.0074 0.0826
Brugia malayi endoprotease bli-4 precursor 0.0143 0.0273 0.0396
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0126 0.023 0.0071
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.013 0.024 0.032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Schistosoma mansoni glutamate receptor NMDA 0.0049 0.0031 0.0033
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0043 0.0014 0.0136
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0015 0.0021
Plasmodium falciparum cysteine repeat modular protein 1 0.0073 0.0092 0.2648
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0105 0.0174 0.0253
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0043 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0212 0.0452 0.0604
Echinococcus granulosus neuropeptide receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0143 0.0273 0.0396
Echinococcus multilocularis neuropeptide s receptor 0.1267 0.3191 0.4261
Schistosoma mansoni hypothetical protein 0.0165 0.033 0.0357
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0082 0.0114 0.0124
Echinococcus granulosus tubulin beta 4A class IVa 0.0066 0.0074 0.0099
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0043 0.0014 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0082 0.0114 0.0166
Schistosoma mansoni voltage-gated cation channel 0.0149 0.029 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0082 0.0114 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0374 0.6366
Echinococcus granulosus ecdysone induced protein 78C 0.0082 0.0114 0.0153
Schistosoma mansoni ryanodine receptor related 0.0043 0.0014 0.0015
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0223 0.0481 0.0836
Schistosoma mansoni protein kinase 0.014 0.0266 0.0288
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0212 0.0452 0.0489
Echinococcus multilocularis dro:myosuppressin receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis jun protein 0.0097 0.0154 0.0206
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0043 0.0014 0.002
Loa Loa (eye worm) apoptosis regulator protein 0.0309 0.0706 0.1024
Echinococcus granulosus orexin receptor type 2 0.0212 0.0452 0.0604
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus granulosus L aminoadipate semialdehyde 0.0095 0.0151 0.0201
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0082 0.0114 0.0166
Onchocerca volvulus 0.0059 0.0055 0.0361
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0082 0.0114 0.0166
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0014 0.0018
Schistosoma mansoni neuropeptide F-like receptor 0.0212 0.0452 0.0489
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0043 0.0014 0.0018
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0082 0.0114 0.0153
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus multilocularis nmda type glutamate receptor 0.0116 0.0205 0.0273
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Brugia malayi Dopamine receptor protein 2 0.0212 0.0452 0.0656
Echinococcus multilocularis potassium large conductance calcium activated 0.0043 0.0014 0.0018
Trypanosoma brucei C-8 sterol isomerase, putative 0.0374 0.0874 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0031 0.0041
Brugia malayi neuroendocrine convertase 1 precursor 0.009 0.0136 0.0197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Brugia malayi TAR-binding protein 0.0073 0.0092 0.0133
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0679 0.1666 0.2417
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0043 0.0014 0.0018
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Onchocerca volvulus 0.0095 0.0151 0.0991
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0212 0.0452 0.0656
Loa Loa (eye worm) PAN domain-containing protein 0.0115 0.0201 0.0292
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0122 0.0218 0.0317
Brugia malayi Transforming growth factor beta like domain containing protein 0.013 0.024 0.0348
Echinococcus granulosus hyperpolarization activated cyclic 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292
Onchocerca volvulus 0.0059 0.0055 0.0361
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0223 0.0481 0.0366
Schistosoma mansoni tyrosine kinase 0.0045 0.0021 0.0023
Echinococcus granulosus neuropeptide Y receptor 0.0212 0.0452 0.0604
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0003 0.0004
Brugia malayi ORL1-like opioid receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis thyroid hormone receptor alpha 0.0082 0.0114 0.0153
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0003 0.0004
Onchocerca volvulus 0.0212 0.0452 0.2975
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0212 0.0452 0.0489
Trichomonas vaginalis heat shock protein, putative 0.0126 0.023 0.3882
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0014 0.0018
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0003 0.0004
Echinococcus multilocularis beta tubulin 0.0066 0.0074 0.0099
Onchocerca volvulus 0.0212 0.0452 0.2975
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.0021 0.0028
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0082 0.0114 0.0124
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Toxoplasma gondii thioredoxin reductase 0.0098 0.0156 0.0315
Onchocerca volvulus 0.0212 0.0452 0.2975
Schistosoma mansoni amine GPCR 0.0212 0.0452 0.0489
Loa Loa (eye worm) DR-78 0.0038 0.0003 0.0004
Echinococcus granulosus shaker cognate 0.0043 0.0014 0.0018
Onchocerca volvulus 0.0038 0.0003 0.0018
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0009 0.0013
Echinococcus granulosus Zinc finger RanBP2 type 0.0059 0.0055 0.0073
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0014 0.0018
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0043 0.0014 0.0015
Loa Loa (eye worm) twinkle helicase 0.0127 0.0232 0.0336
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0021
Brugia malayi cation channel family protein 0.0043 0.0014 0.002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0098 0.0158 0.0211
Onchocerca volvulus 0.0059 0.0055 0.0361
Toxoplasma gondii hypothetical protein 0.0107 0.018 0.0366
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0003 0.0018
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0074 0.0099
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0043 0.0014 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Echinococcus multilocularis SWI:SNF matrix associated 0.0165 0.033 0.0441
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.035 0.2303
Echinococcus multilocularis endoplasmin 0.0126 0.023 0.0308
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Brugia malayi hypothetical protein 0.0839 0.2079 0.3017
Plasmodium vivax heat shock protein 86, putative 0.0139 0.0264 0.7436
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0212 0.0452 0.0656
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0087 0.0128 0.0171
Echinococcus multilocularis somatostatin receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis fmrfamide receptor 0.0212 0.0452 0.0604
Brugia malayi hypothetical protein 0.0043 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0095 0.0151 0.0219
Echinococcus multilocularis adenylate cyclase type IX 0.0086 0.0127 0.017
Schistosoma mansoni neuropeptide F-like receptor 0.0212 0.0452 0.0489
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0122 0.0218 0.0317
Schistosoma mansoni hypothetical protein 0.0073 0.0092 0.0099
Trichomonas vaginalis tubulin alpha chain, putative 0.0066 0.0074 0.1179
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Echinococcus multilocularis heat shock protein 90 0.0126 0.023 0.0308
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Echinococcus granulosus thioredoxin glutathione reductase 0.0098 0.0158 0.0211
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0059 0.0055 0.0608
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0074 0.0099
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0126 0.023 0.0019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0009 0.0013
Onchocerca volvulus 0.0212 0.0452 0.2975
Echinococcus granulosus neuropeptides capa receptor 0.0212 0.0452 0.0604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.033 0.5608
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Schistosoma mansoni tubulin subunit beta 0.0066 0.0074 0.008
Schistosoma mansoni brg-1 associated factor 0.0165 0.033 0.0357
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Schistosoma mansoni hypothetical protein 0.0679 0.1666 0.1802
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0082 0.0114 0.0153
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus multilocularis sodium leak channel non selective protein 0.0043 0.0014 0.0018
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0043 0.0014 0.0018
Trypanosoma brucei beta tubulin 0.0066 0.0074 0.0826
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0165 0.033 0.0699
Echinococcus granulosus serotonin receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0043 0.0014 0.002
Brugia malayi GnHR receptor homolog 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0212 0.0452 0.0604
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0114 0.0153
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Brugia malayi map kinase activated protein kinase protein 2 0.0183 0.0377 0.0547
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Schistosoma mansoni tubulin subunit beta 0.0066 0.0074 0.008
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.0584 0.0848
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0026 0.0034
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0275 0.0617 0.0824
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0059 0.0055 0.0608
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1263 0.3183 0.425
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0043 0.0014 0.0018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0082 0.0114 0.0153
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0014 0.0015
Brugia malayi Serotonin receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0212 0.0452 0.0604
Echinococcus granulosus adenylate cyclase type IX 0.0086 0.0127 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0584 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0212 0.0452 0.0489
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0092 0.0099
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Brugia malayi RE15519p 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus neuroendocrine convertase 2 0.009 0.0136 0.0181
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Echinococcus multilocularis tissue type plasminogen activator 0.0073 0.0092 0.0122
Echinococcus granulosus g protein coupled receptor 0.0212 0.0452 0.0604
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0015 0.002
Echinococcus granulosus potassium large conductance calcium activated 0.0043 0.0014 0.0018
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi ecdysone receptor 0.0038 0.0003 0.0004
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0082 0.0114 0.0166
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0074 0.0099
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.008
Trypanosoma brucei calpain, putative 0.0117 0.0207 0.2355
Echinococcus granulosus tar DNA binding protein 0.0073 0.0092 0.0122
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.0021 0.0028
Trypanosoma brucei hypothetical protein 0.0117 0.0207 0.2355
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0212 0.0452 0.0489
Echinococcus granulosus SWI:SNF matrix associated 0.0165 0.033 0.0441
Trypanosoma cruzi Heat shock protein 83, putative 0.0139 0.0264 0.301
Schistosoma mansoni nuclear receptor 0.0038 0.0003 0.0003
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.2922 0.7488 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus multilocularis glutamate receptor 2 0.0049 0.0031 0.0041
Loa Loa (eye worm) endoplasmin 0.0139 0.0264 0.0384
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Schistosoma mansoni transient receptor potential channel 0.0043 0.0014 0.0015
Schistosoma mansoni biogenic amine receptor 0.0212 0.0452 0.0489
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0117 0.0207 0.2355
Brugia malayi brahma associated protein 60 kDa 0.0165 0.033 0.0479
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0082 0.0114 0.0153
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Schistosoma mansoni amine GPCR 0.0212 0.0452 0.0489
Plasmodium vivax endoplasmin, putative 0.0139 0.0264 0.7436
Onchocerca volvulus 0.0115 0.0201 0.1326
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0931 0.2319 0.3097
Schistosoma mansoni transient receptor potential channel 4 0.0043 0.0014 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Brugia malayi SRC-1 0.0045 0.0021 0.003
Loa Loa (eye worm) BEN-1 protein 0.0066 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trichomonas vaginalis tubulin beta chain, putative 0.0066 0.0074 0.1179
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0165 0.033 0.0479
Schistosoma mansoni myosin xvIII 0.0212 0.0452 0.0489
Echinococcus granulosus sodium leak channel non selective protein 0.0043 0.0014 0.0018
Chlamydia trachomatis DNA topoisomerase I 0.0165 0.033 0.225
Loa Loa (eye worm) RNA binding protein 0.0073 0.0092 0.0133
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0584 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0212 0.0452 0.0604
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292
Loa Loa (eye worm) PAN domain-containing protein 0.0115 0.0201 0.0292
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0449 0.1068 1
Brugia malayi ion channel NompC 0.0043 0.0014 0.002
Schistosoma mansoni TRABID protein (C64 family) 0.0059 0.0055 0.0059
Toxoplasma gondii kringle domain-containing protein 0.0073 0.0092 0.0172
Brugia malayi Calcitonin receptor-like protein seb-1 0.2039 0.5196 0.7539
Echinococcus granulosus G protein coupled receptor 139 0.0212 0.0452 0.0604
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0074 0.0099
Echinococcus granulosus two pore calcium channel protein 2 0.0043 0.0014 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0082 0.0114 0.0166
Echinococcus multilocularis neuropeptide Y receptor 0.0212 0.0452 0.0604
Echinococcus granulosus neuropeptide Y receptor 0.0212 0.0452 0.0604
Leishmania major hypothetical protein, conserved 0.0059 0.0055 0.039
Loa Loa (eye worm) hypothetical protein 0.0056 0.0048 0.007
Brugia malayi Cyclic-nucleotide gated cation channel 0.0043 0.0014 0.002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0092 0.0099
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Loa Loa (eye worm) tubulin beta-1 chain 0.0066 0.0074 0.0107
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0082 0.0114 0.0166
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0212 0.0452 0.0604
Schistosoma mansoni hypothetical protein 0.0212 0.0452 0.0489
Echinococcus granulosus heat shock protein 90 0.0139 0.0264 0.0353
Schistosoma mansoni neuropeptide receptor 0.0212 0.0452 0.0489
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0116 0.0205 0.0273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0212 0.0452 0.0489
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0003 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus multilocularis neuropeptide receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0014 0.0018
Giardia lamblia Beta tubulin 0.0066 0.0074 0.1493
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0082 0.0114 0.0166
Onchocerca volvulus 0.0115 0.0201 0.1326
Brugia malayi follicle stimulating hormone receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0679 0.1666 0.2225
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0165 0.033 0.0441
Mycobacterium tuberculosis Probable dehydrogenase 0.0223 0.0481 0.0366
Loa Loa (eye worm) pigment dispersing factor receptor c 0.2039 0.5196 0.7539
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.008
Echinococcus multilocularis two pore calcium channel protein 1 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0248 0.0546 0.0431
Schistosoma mansoni endoplasmin 0.0139 0.0264 0.0286
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0107 0.018 0.0261
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0059 0.0055 0.0073
Loa Loa (eye worm) hypothetical protein 0.0062 0.0063 0.0091
Schistosoma mansoni RAR-like nuclear receptor 0.0082 0.0114 0.0124
Schistosoma mansoni retinoic acid receptor RXR 0.0082 0.0114 0.0124
Plasmodium falciparum heat shock protein 90 0.0139 0.0264 0.7975
Echinococcus multilocularis G protein coupled receptor 139 0.0212 0.0452 0.0604
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0082 0.0114 0.0153
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Echinococcus granulosus neuropeptides capa receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis fmrfamide receptor 0.0212 0.0452 0.0604
Echinococcus granulosus glutamate NMDA receptor subunit 0.0275 0.0617 0.0824
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus multilocularis sodium channel protein 0.0449 0.1068 0.1426
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0165 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0043 0.0014 0.0091
Brugia malayi neuropeptide F receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0191 0.0399 0.058
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0165 0.033 0.0699
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0003 0.0003
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0212 0.0452 0.0656
Echinococcus granulosus neuropeptide s receptor 0.1267 0.3191 0.4261
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.1332 0.3362 0.4489
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0092 0.0099
Loa Loa (eye worm) hypothetical protein 0.0514 0.1238 0.1796
Loa Loa (eye worm) SRC-1 0.0045 0.0021 0.003
Loa Loa (eye worm) brahma associated protein 0.0165 0.033 0.0479
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.0021 0.0028
Trypanosoma brucei RNA helicase, putative 0.0114 0.0198 0.2243
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0043 0.0014 0.0018
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0059 0.0055 0.1515
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Echinococcus multilocularis geminin 0.0194 0.0408 0.0545
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0212 0.0452 0.0604
Schistosoma mansoni zinc finger protein 0.0038 0.0003 0.0003
Brugia malayi Kringle domain containing protein 0.0073 0.0092 0.0133
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0117 0.0207 0.2355
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0114 0.0124
Loa Loa (eye worm) PAN domain-containing protein 0.0115 0.0201 0.0292
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0031 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Echinococcus granulosus dro:myosuppressin receptor 0.0212 0.0452 0.0604
Brugia malayi Protein kinase domain containing protein 0.0105 0.0174 0.0253
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis adenylate cyclase 9 0.0062 0.0063 0.0084
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0149 0.029 0.3308
Schistosoma mansoni voltage-dependent calcium channel 0.0043 0.0014 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0082 0.0114 0.0153
Schistosoma mansoni hypothetical protein 0.0165 0.033 0.0357
Loa Loa (eye worm) tubulin beta chain 0.0066 0.0074 0.0107
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0066 0.0074 0.0099
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0043 0.0014 0.002
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0074 0.0099
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0126 0.023 0.0308
Echinococcus granulosus heat shock protein 90 0.0126 0.023 0.0308
Schistosoma mansoni hypothetical protein 0.0679 0.1666 0.1802
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0212 0.0452 0.2975
Onchocerca volvulus 0.0623 0.152 1
Schistosoma mansoni hypothetical protein 0.0043 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292
Brugia malayi nuclear hormone receptor 0.0038 0.0003 0.0004
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0212 0.0452 0.0489
Brugia malayi nuclear hormone receptor 0.0082 0.0114 0.0166
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0003 0.0003
Echinococcus multilocularis transfer RNA-Gly 0.0043 0.0014 0.0018
Trypanosoma brucei hypothetical protein, conserved 0.0059 0.0055 0.0608
Trypanosoma cruzi trypanothione reductase, putative 0.0098 0.0156 0.1772
Toxoplasma gondii PAN domain-containing protein 0.1787 0.4541 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Toxoplasma gondii hypothetical protein 0.0115 0.0201 0.0414
Onchocerca volvulus 0.0059 0.0056 0.0368
Schistosoma mansoni hypothetical protein 0.0114 0.0198 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Chlamydia trachomatis SWIB complex protein 0.0165 0.033 0.225
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0043 0.0014 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0082 0.0114 0.0166
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0149 0.029 0.3308
Schistosoma mansoni neuropeptide receptor 0.0212 0.0452 0.0489
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Echinococcus granulosus g-protein coupled receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0183 0.0377 0.0503
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0082 0.0114 0.0153
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0003 0.0004
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0212 0.0452 0.0489
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0059 0.0055 0.008
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0117 0.0207 0.2355
Onchocerca volvulus 0.0115 0.0201 0.1326
Brugia malayi sulfakinin receptor protein 0.0839 0.2079 0.3017
Toxoplasma gondii beta-1 tubulin, putative 0.0066 0.0074 0.0133
Brugia malayi hypothetical protein 0.0076 0.01 0.0146
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0055 0.0608
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0212 0.0452 0.0489
Loa Loa (eye worm) voltage-gated potassium channel 0.0043 0.0014 0.002
Brugia malayi heat shock protein 90 0.0139 0.0264 0.0384
Onchocerca volvulus 0.0115 0.0201 0.1326
Schistosoma mansoni heat shock protein 0.0139 0.0264 0.0286
Schistosoma mansoni hypothetical protein 0.0309 0.0706 0.0763
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0082 0.0114 0.0753
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Schistosoma mansoni tubulin subunit beta 0.0066 0.0074 0.008
Schistosoma mansoni neuropeptide receptor 0.0212 0.0452 0.0489
Mycobacterium ulcerans heat shock protein 90 0.0126 0.023 0.2184
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0165 0.033 1
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0309 0.0706 0.0942
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0015 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0082 0.0114 0.0166
Echinococcus multilocularis calcium activated potassium channel 0.0044 0.0018 0.0025
Leishmania major hypothetical protein, conserved 0.0059 0.0055 0.039
Trypanosoma cruzi heat shock protein 85, putative 0.0139 0.0264 0.301
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Loa Loa (eye worm) G-protein coupled receptor 0.0212 0.0452 0.0656
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0074 0.0099
Chlamydia trachomatis replicative DNA helicase 0.0444 0.1054 1
Echinococcus multilocularis orexin receptor type 2 0.0212 0.0452 0.0604
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0043 0.0014 0.002
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Schistosoma mansoni hypothetical protein 0.0212 0.0452 0.0489
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0082 0.0114 0.0124
Loa Loa (eye worm) calcium channel 0.0149 0.029 0.0422
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0014 0.0015
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0248 0.0546 0.1046
Schistosoma mansoni transient receptor potential channel 0.0043 0.0014 0.0015
Echinococcus multilocularis g protein coupled receptor 0.0212 0.0452 0.0604
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0149 0.029 0.0314
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Onchocerca volvulus 0.0212 0.0452 0.2975
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi beta-tubulin, identical 0.0066 0.0074 0.0107
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.0259 0.0375
Echinococcus granulosus short transient receptor potential channel 6 0.0043 0.0014 0.0018
Echinococcus granulosus GPCR family 2 0.0679 0.1666 0.2225
Brugia malayi Melatonin receptor type 1A 0.0212 0.0452 0.0656
Echinococcus multilocularis transient receptor potential gamma protein 0.0043 0.0014 0.0018
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0584 1
Onchocerca volvulus 0.0115 0.0201 0.1326
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0212 0.0452 0.0656
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0043 0.0014 0.0018
Brugia malayi Tachykinin-like peptides receptor 99D 0.0212 0.0452 0.0656
Brugia malayi protein-tyrosine kinase 0.0041 0.0009 0.0014
Trichomonas vaginalis tubulin, putative 0.0066 0.0074 0.1179
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0003 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0105 0.0174 0.2917
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.0259 0.0375
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Echinococcus granulosus peptide allatostatin:somatostatin 0.0212 0.0452 0.0604
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Onchocerca volvulus 0.0212 0.0452 0.2975
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni zinc finger protein 0.0059 0.0055 0.0059
Leishmania major hypothetical protein, conserved 0.0059 0.0055 0.039
Plasmodium vivax hypothetical protein, conserved 0.0165 0.033 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0043 0.0014 0.002
Brugia malayi cation channel family protein 0.0043 0.0014 0.002
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0043 0.0014 0.0015
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0059 0.0055 0.008
Loa Loa (eye worm) steroid hormone receptor 0.0082 0.0114 0.0166
Onchocerca volvulus 0.0212 0.0452 0.2975
Trypanosoma brucei Heat shock protein 83, putative 0.0139 0.0264 0.301
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0114 0.0166
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0043 0.0014 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.0174 0.0189
Echinococcus multilocularis neuropeptides capa receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0082 0.0114 0.0153
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus granulosus transient receptor potential gamma protein 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni hypothetical protein 0.0212 0.0452 0.0489
Echinococcus multilocularis 0.0115 0.0202 0.0269
Echinococcus granulosus geminin 0.0194 0.0408 0.0545
Schistosoma mansoni thyroid hormone receptor 0.0082 0.0114 0.0124
Echinococcus multilocularis tubulin beta 1 chain 0.0066 0.0074 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0082 0.0114 0.0166
Echinococcus granulosus hyperpolarization activated cyclic 0.0043 0.0014 0.0018
Loa Loa (eye worm) endoprotease bli-4 0.0143 0.0273 0.0396
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Brugia malayi G-protein coupled receptor 0.0212 0.0452 0.0656
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Schistosoma mansoni nuclear receptor 0.0038 0.0003 0.0003
Schistosoma mansoni furin-1 (S08 family) 0.0062 0.0064 0.0069
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0679 0.1666 0.2417
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0043 0.0014 0.0018
Echinococcus multilocularis neuropeptides capa receptor 0.0212 0.0452 0.0604
Toxoplasma gondii hypothetical protein 0.0115 0.0201 0.0414
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0105 0.0174 0.0233
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0212 0.0452 0.0489
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0092 0.0122
Echinococcus multilocularis neuropeptide FF receptor 2 0.0212 0.0452 0.0604
Brugia malayi photoreceptor-specific nuclear receptor 0.0082 0.0114 0.0166
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0082 0.0114 0.0153
Entamoeba histolytica tubulin family protein 0.0066 0.0074 0.251
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0062 0.0063 0.0413
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.001 0.0011
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0014 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0049 0.0031 0.0041
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0003 0.0004
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0087 0.0128 0.0171
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni opsin-like receptor 0.0212 0.0452 0.0489
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni neuropeptide receptor 0.0212 0.0452 0.0489
Echinococcus granulosus endoplasmin 0.0126 0.023 0.0308
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0049 0.0031 0.0041
Brugia malayi AKH receptor 0.0212 0.0452 0.0656
Echinococcus granulosus sodium channel protein 0.0449 0.1068 0.1426
Echinococcus granulosus alpha 1A adrenergic receptor 0.0212 0.0452 0.0604
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0212 0.0452 0.0489
Trichomonas vaginalis AGC family protein kinase 0.0105 0.0174 0.2917
Onchocerca volvulus 0.0073 0.0092 0.0603
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0149 0.029 0.0388
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.001 0.0013
Toxoplasma gondii heat shock protein HSP90 0.0139 0.0264 0.0554
Schistosoma mansoni coup transcription factor 0.0082 0.0114 0.0124
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.001 0.0013
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0059 0.0055 0.0608
Loa Loa (eye worm) hypothetical protein 0.0623 0.152 0.2205
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0092 0.0133
Schistosoma mansoni hypothetical protein 0.0194 0.0408 0.0441
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0223 0.0481 0.0366
Mycobacterium ulcerans recombinase A 0.0124 0.0224 0.2129
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0212 0.0452 0.0489
Echinococcus granulosus ryanodine receptor 44f 0.0043 0.0014 0.0018
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.0021 0.0028
Trypanosoma cruzi heat shock protein 85, putative 0.0126 0.023 0.2618
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0043 0.0014 0.002
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0082 0.0114 0.0166
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0003 0.0004
Echinococcus multilocularis neuropeptide receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0309 0.0706 0.1024
Schistosoma mansoni amine GPCR 0.0212 0.0452 0.0489
Loa Loa (eye worm) heat shock protein 90 0.0139 0.0264 0.0384
Brugia malayi SWIB/MDM2 domain containing protein 0.0165 0.033 0.0479
Schistosoma mansoni adenoreceptor 0.0212 0.0452 0.0489
Brugia malayi MH2 domain containing protein 0.0137 0.0259 0.0375
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0043 0.0014 0.0139
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0059 0.0055 0.0608
Echinococcus granulosus voltage gated potassium channel 0.0043 0.0014 0.0018
Echinococcus granulosus g protein coupled receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Onchocerca volvulus 0.0212 0.0452 0.2975
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi G-protein coupled receptor 0.0212 0.0452 0.0656
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Onchocerca volvulus 0.0048 0.0027 0.0177
Schistosoma mansoni amine GPCR 0.0212 0.0452 0.0489
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0098 0.0156 0.0037
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Trichomonas vaginalis heat shock protein, putative 0.0139 0.0264 0.4473
Schistosoma mansoni hypothetical protein 0.0041 0.001 0.0011
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0014 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0082 0.0114 0.0124
Onchocerca volvulus 0.0212 0.0452 0.2975
Toxoplasma gondii subtilisin SUB12 0.0121 0.0217 0.0449
Trypanosoma brucei heat shock protein, putative 0.0139 0.0264 0.301
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0055 0.0608
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0165 0.033 0.0441
Giardia lamblia Beta tubulin 0.0066 0.0074 0.1493
Brugia malayi Endoplasmin precursor 0.0139 0.0264 0.0384
Echinococcus granulosus tm gpcr rhodopsin 0.0212 0.0452 0.0604
Treponema pallidum recombinase A 0.0124 0.0224 0.1119
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0212 0.0452 0.0656
Schistosoma mansoni histamine h1 receptor 0.0212 0.0452 0.0489
Toxoplasma gondii PAN domain-containing protein 0.0115 0.0201 0.0414
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0009 0.0013
Echinococcus granulosus voltage dependent calcium channel 0.0149 0.029 0.0388
Loa Loa (eye worm) voltage-gated calcium channel 0.0043 0.0014 0.002
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0043 0.0014 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.2692 0.6891 1
Onchocerca volvulus 0.0212 0.0452 0.2975
Toxoplasma gondii PAN domain-containing protein 0.0115 0.0201 0.0414
Toxoplasma gondii microneme protein, putative 0.0115 0.0201 0.0414
Echinococcus multilocularis zinc finger protein Ran binding 0.0059 0.0055 0.0073
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0115 0.0201 0.0414
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni tubulin subunit beta 0.0066 0.0074 0.008
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0043 0.0014 0.0018
Echinococcus multilocularis FTZ F1 alpha 0.0082 0.0114 0.0153
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0095 0.0151 0.0219
Onchocerca volvulus 0.0062 0.0063 0.0413
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0043 0.0014 0.0091
Chlamydia trachomatis recombinase RecA 0.0124 0.0224 0.1119
Echinococcus multilocularis g protein coupled receptor 0.0212 0.0452 0.0604
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0014 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0015 0.002
Schistosoma mansoni hypothetical protein 0.0212 0.0452 0.0489
Schistosoma mansoni hypothetical protein 0.0079 0.0107 0.0116
Loa Loa (eye worm) hypothetical protein 0.0374 0.0874 0.1269
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0059 0.0055 0.0608
Onchocerca volvulus 0.0115 0.0201 0.1326
Giardia lamblia Heat shock protein HSP 90-alpha 0.0126 0.023 0.8476
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0014 0.0018
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0043 0.0014 0.0136
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0097 0.0154 0.0206
Onchocerca volvulus 0.0082 0.0114 0.0753
Toxoplasma gondii beta-tubulin, putative 0.0066 0.0074 0.0133
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0165 0.033 0.0357
Echinococcus granulosus g protein coupled receptor 0.0212 0.0452 0.0604
Treponema pallidum replicative DNA helicase (dnaB) 0.0444 0.1054 1
Treponema pallidum heat shock protein 90 0.0126 0.023 0.1182
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0074 0.0099
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0449 0.1068 0.1426
Echinococcus multilocularis serotonin receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0006 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus granulosus short transient receptor potential channel 6 0.0043 0.0014 0.0018
Schistosoma mansoni hypothetical protein 0.0679 0.1666 0.1802
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.357 0.917 0.916
Echinococcus granulosus biogenic amine 5HT receptor 0.0212 0.0452 0.0604
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0043 0.0014 0.0018
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0374 0.0874 0.1269
Trypanosoma cruzi WLM domain containing protein, putative 0.0059 0.0055 0.0608
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Schistosoma mansoni transient receptor potential channel 0.0043 0.0014 0.0015
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Entamoeba histolytica heat shock protein 90, putative 0.0139 0.0264 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0066 0.0074 0.0099
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0003 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0074 0.0099
Onchocerca volvulus 0.0212 0.0452 0.2975
Echinococcus multilocularis voltage dependent calcium channel 0.0149 0.029 0.0388
Loa Loa (eye worm) thioredoxin reductase 0.0098 0.0156 0.0227
Giardia lamblia Heat shock protein HSP 90-alpha 0.0139 0.0264 1
Onchocerca volvulus 0.0165 0.033 0.2172
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0043 0.0014 0.0018
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0014 0.0018
Entamoeba histolytica tubulin family protein 0.0066 0.0074 0.251
Entamoeba histolytica heat shock protein 90, putative 0.0139 0.0264 1
Echinococcus multilocularis voltage gated potassium channel 0.0043 0.0014 0.0018
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0009 0.0013
Echinococcus granulosus heat shock protein 0.0139 0.0264 0.0353
Loa Loa (eye worm) adenylyl cyclase 3 0.0145 0.028 0.0407
Plasmodium falciparum tubulin beta chain 0.0066 0.0074 0.2103
Plasmodium vivax thioredoxin reductase, putative 0.0098 0.0156 0.3222
Schistosoma mansoni apoptosis regulator bax 0.0309 0.0706 0.0763
Toxoplasma gondii PAN domain-containing protein 0.1787 0.4541 1
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0059 0.0055 0.0073
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0082 0.0114 0.0153
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.014 0.0266 0.0355
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0679 0.1666 0.2225
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0092 0.0099
Trichomonas vaginalis heat shock protein, putative 0.0126 0.023 0.3882
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0128 0.2113
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0003 0.0004
Leishmania major C-8 sterol isomerase-like protein 0.0374 0.0874 0.8162
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0168 0.0339 0.0492
Brugia malayi Protein kinase domain containing protein 0.0074 0.0095 0.0138
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.2922 0.7488 1
Toxoplasma gondii heat shock protein 90, putative 0.0139 0.0264 0.0554
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.2692 0.6891 1
Onchocerca volvulus 0.0115 0.0201 0.1326
Brugia malayi conserved hypotetical protein 0.0038 0.0003 0.0004
Leishmania major hypothetical protein, conserved 0.0059 0.0055 0.039
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0183 0.0377 0.0503
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.035 0.595
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0043 0.0014 0.002
Echinococcus granulosus nmda type glutamate receptor 0.0116 0.0205 0.0273
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0212 0.0452 0.0656
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0374 0.0874 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0082 0.0114 0.0153
Loa Loa (eye worm) hypothetical protein 0.0107 0.018 0.0261
Schistosoma mansoni hypothetical protein 0.0309 0.0706 0.0763
Schistosoma mansoni calcium-activated potassium channel 0.0043 0.0014 0.0015
Echinococcus granulosus tm gpcr rhodopsin 0.1263 0.3183 0.425
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0212 0.0452 0.0604
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0009 0.0013
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0309 0.0706 0.0942
Trypanosoma cruzi WLM domain containing protein, putative 0.0059 0.0055 0.0608
Echinococcus granulosus tyrosine kinase 0.0041 0.0009 0.0013
Leishmania major hypothetical protein, conserved 0.0073 0.0092 0.0738
Loa Loa (eye worm) hypothetical protein 0.0839 0.2079 0.3017
Schistosoma mansoni RNA binding protein 0.0059 0.0055 0.0059
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0149 0.029 0.0388
Loa Loa (eye worm) hypothetical protein 0.0059 0.0055 0.008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0082 0.0114 0.0124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.1332 0.3362 0.4489
Toxoplasma gondii beta tubulin 0.0066 0.0074 0.0133
Echinococcus granulosus neuropeptide receptor 0.0212 0.0452 0.0604
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.0021 0.0028
Brugia malayi RNA binding protein 0.0073 0.0092 0.0133
Schistosoma mansoni neuropeptide f receptor 76f 0.0212 0.0452 0.0489
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0212 0.0452 0.0604
Brugia malayi nuclear receptor RXR 0.0038 0.0003 0.0004
Echinococcus granulosus TRP transient receptor potential channel 0.0043 0.0014 0.0018
Schistosoma mansoni 60S ribosomal protein L21 0.0043 0.0014 0.0015
Schistosoma mansoni protein kinase 0.014 0.0266 0.0288
Echinococcus multilocularis potassium voltage gated channel protein 0.0043 0.0014 0.0018
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0223 0.0481 0.0366
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0444 0.1054 1
Schistosoma mansoni tubulin subunit beta 0.0066 0.0074 0.008
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Onchocerca volvulus 0.0115 0.0201 0.1326
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Echinococcus multilocularis heat shock protein 90 0.0139 0.0264 0.0353
Onchocerca volvulus 0.0115 0.0201 0.1326
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0084 0.012 0.1137
Trypanosoma brucei beta tubulin 0.0066 0.0074 0.0826
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0014 0.0018
Echinococcus multilocularis allatostatin A receptor 0.0623 0.152 0.2029
Mycobacterium tuberculosis Probable oxidoreductase 0.0248 0.0546 0.0431
Brugia malayi Dopamine receptor protein 1 0.0212 0.0452 0.0656
Onchocerca volvulus 0.0212 0.0452 0.2975
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0003 0.0004
Echinococcus granulosus Tubulin beta 2C chain 0.0066 0.0074 0.0099
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0248 0.0546 0.0431
Schistosoma mansoni biogenic amine receptor 0.0212 0.0452 0.0489
Schistosoma mansoni opsin-like receptor 0.0212 0.0452 0.0489
Brugia malayi latrophilin 2 splice variant baaae 0.136 0.3433 0.4981
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0059 0.0055 0.008
Echinococcus multilocularis serotonin receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.0584 0.0848
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0003 0.0004
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0003 0.0004
Onchocerca volvulus 0.0212 0.0452 0.2975
Brugia malayi neuropeptide F receptor 0.0212 0.0452 0.0656
Trichomonas vaginalis tubulin epsilon chain, putative 0.0066 0.0074 0.1179
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Onchocerca volvulus Protein ultraspiracle homolog 0.0082 0.0114 0.0753
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Entamoeba histolytica protein kinase, putative 0.0105 0.0174 0.6461
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292
Schistosoma mansoni biogenic amine (5HT) receptor 0.0212 0.0452 0.0489
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0212 0.0452 0.0604
Echinococcus granulosus sex peptide receptor 0.0212 0.0452 0.0604
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0043 0.0014 0.002
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0082 0.0114 0.0166
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0043 0.0014 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0003 0.0004
Echinococcus granulosus two pore calcium channel protein 1 0.0043 0.0014 0.0018
Toxoplasma gondii microneme protein MIC4 0.0115 0.0201 0.0414
Loa Loa (eye worm) beta-tubulin 0.0066 0.0074 0.0107
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0014 0.0018
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0021 0.0028
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0043 0.0014 0.0018
Brugia malayi steroid hormone receptor 0.0082 0.0114 0.0166
Schistosoma mansoni hypothetical protein 0.136 0.3433 0.3713
Loa Loa (eye worm) voltage-dependent calcium channel 0.0149 0.029 0.0422
Schistosoma mansoni nuclear hormone receptor 0.0082 0.0114 0.0124
Loa Loa (eye worm) melatonin receptor type 1A 0.0212 0.0452 0.0656
Trypanosoma brucei beta tubulin 0.0066 0.0074 0.0826
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0059 0.0055 0.008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Trichomonas vaginalis AGC family protein kinase 0.0105 0.0174 0.2917
Leishmania major heat shock protein 83-1 0.0139 0.0264 0.2377
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0584 1
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0082 0.0114 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.0059 0.0055 0.0608
Echinococcus multilocularis rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Leishmania major hypothetical protein, conserved 0.0059 0.0055 0.039
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0143 0.0273 0.0296
Brugia malayi nuclear receptor RXR 0.0043 0.0015 0.0021
Echinococcus multilocularis SWI:SNF matrix associated 0.0165 0.033 0.0441
Loa Loa (eye worm) hypothetical protein 0.0043 0.0014 0.002
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.0021 0.0028
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Schistosoma mansoni opsin-like receptor 0.0212 0.0452 0.0489
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0309 0.0706 0.1024
Toxoplasma gondii ran binding protein 0.0059 0.0055 0.0091
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0444 0.1054 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0212 0.0452 0.0489
Echinococcus multilocularis transient receptor potential cation channel 0.0043 0.0014 0.0018
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0105 0.0174 0.0233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0015 0.0021
Trypanosoma cruzi heat shock protein 90, putative 0.0126 0.023 0.2618
Brugia malayi hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0043 0.0014 0.002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0212 0.0452 0.0604
Loa Loa (eye worm) hypothetical protein 0.0038 0.0003 0.0004
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0014 0.0018
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Echinococcus granulosus tubulin beta 1 chain 0.0066 0.0074 0.0099
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.013 0.024 0.032
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0003 0.0003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0082 0.0114 0.0124
Echinococcus granulosus furin 0.0143 0.0273 0.0365
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0149 0.029 0.0388
Loa Loa (eye worm) voltage-gated potassium channel 0.0043 0.0014 0.002
Schistosoma mansoni serine-type protease inhibitor 0.3599 0.9245 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0095 0.0151 0.0201
Brugia malayi brahma associated protein 60 kDa 0.0165 0.033 0.0479
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Toxoplasma gondii microneme protein MIC17C 0.0115 0.0201 0.0414
Schistosoma mansoni tubulin subunit beta 0.0066 0.0074 0.008
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0043 0.0014 0.0015
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0043 0.0014 0.0018
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0003 0.0004
Trypanosoma brucei calpain-like protein, putative 0.0117 0.0207 0.2355
Brugia malayi Latrophilin receptor protein 2 0.0679 0.1666 0.2417
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0082 0.0114 0.0166
Loa Loa (eye worm) tubulin beta-2A chain 0.0066 0.0074 0.0107
Onchocerca volvulus 0.0115 0.0201 0.1326
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0006 0.0008
Trypanosoma brucei heat shock protein 90, putative 0.0139 0.0264 0.301
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0043 0.0014 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0082 0.0114 0.0166
Giardia lamblia Grp94/Hsp90 0.0126 0.023 0.8476
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0003 0.0003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0212 0.0452 0.0604
Brugia malayi nuclear receptor NHR-88 0.0038 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Schistosoma mansoni glutamate receptor NMDA 0.0275 0.0617 0.0667
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0003 0.0004
Echinococcus granulosus allatostatin A receptor 0.0623 0.152 0.2029
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0309 0.0706 0.0763
Echinococcus granulosus beta tubulin 0.0066 0.0074 0.0099
Echinococcus granulosus beta tubulin 0.0066 0.0074 0.0099
Loa Loa (eye worm) G-protein coupled receptor 0.0212 0.0452 0.0656
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0212 0.0452 0.0604
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0021 0.0028
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0165 0.033 1
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0059 0.0055 0.0361
Brugia malayi larval opioid receptor 0.0212 0.0452 0.0656
Brugia malayi hypothetical protein 0.0043 0.0015 0.0021
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0623 0.152 0.1644
Echinococcus granulosus rhodopsin orphan GPCR 0.0212 0.0452 0.0604
Trichomonas vaginalis heat shock protein, putative 0.0126 0.023 0.3882
Echinococcus granulosus 7tm_1 domain containing protein 0.0212 0.0452 0.0604
Echinococcus granulosus potassium voltage gated channel protein 0.0043 0.0014 0.0018
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0014 0.0018
Onchocerca volvulus 0.0212 0.0452 0.2975
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0212 0.0452 0.0489
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0043 0.0014 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.0082 0.0114 0.0166
Mycobacterium leprae Conserved hypothetical protein 0.1308 0.3298 1
Echinococcus granulosus glutamate receptor 2 0.0049 0.0031 0.0041
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0212 0.0452 0.0489
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.0584 1
Loa Loa (eye worm) ryanodine receptor 0.0043 0.0014 0.002
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0043 0.0014 0.0018
Echinococcus granulosus tubulin subunit beta 0.0066 0.0074 0.0099
Schistosoma mansoni protein kinase 0.014 0.0266 0.0288
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Loa Loa (eye worm) hypothetical protein 0.136 0.3433 0.4981
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Loa Loa (eye worm) neuropeptide F receptor 0.0212 0.0452 0.0656
Brugia malayi hypothetical protein 0.0041 0.001 0.0015
Brugia malayi hypothetical protein 0.0043 0.0015 0.0021
Loa Loa (eye worm) hypothetical protein 0.0094 0.0148 0.0214
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0126 0.023 0.2054
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0082 0.0114 0.0166
Schistosoma mansoni serine-type protease inhibitor 0.3599 0.9245 1
Schistosoma mansoni two-pore calcium channel 0.0043 0.0014 0.0015
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0014 0.0015
Brugia malayi G protein-coupled receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.0021 0.0028
Echinococcus multilocularis short transient receptor potential channel 6 0.0043 0.0014 0.0018
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0059 0.0055 0.0608
Brugia malayi tailless protein 0.0038 0.0003 0.0004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0015 0.0016
Onchocerca volvulus 0.0212 0.0452 0.2975
Echinococcus granulosus jun protein 0.0097 0.0154 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0092 0.0099
Echinococcus multilocularis beta tubulin 0.0066 0.0074 0.0099
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0043 0.0014 0.002
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0126 0.023 0.0112
Schistosoma mansoni endoplasmin 0.0139 0.0264 0.0286
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Leishmania major beta tubulin 0.0066 0.0074 0.0571
Loa Loa (eye worm) hypothetical protein 0.0212 0.0452 0.0656
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0149 0.029 0.0422
Brugia malayi Tubulin beta-1 chain 0.0066 0.0074 0.0107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0082 0.0114 0.0124
Loa Loa (eye worm) neuropeptide F receptor 0.0212 0.0452 0.0656
Echinococcus multilocularis shaker cognate 0.0043 0.0014 0.0018
Echinococcus multilocularis SWI:SNF matrix associated 0.0165 0.033 0.0441
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0092 0.0133
Loa Loa (eye worm) hypothetical protein 0.0073 0.0092 0.0133
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0043 0.0014 0.0018
Brugia malayi PAN domain containing protein 0.0115 0.0201 0.0292
Brugia malayi voltage-dependent calcium channel 0.0043 0.0014 0.002
Toxoplasma gondii microneme protein MIC17B 0.0115 0.0201 0.0414
Echinococcus multilocularis ring and YY1 binding protein 0.0059 0.0055 0.0073
Brugia malayi celfurPC protein 0.0115 0.0202 0.0292
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0117 0.0207 0.2355
Echinococcus multilocularis neuropeptide Y receptor 0.0212 0.0452 0.0604
Echinococcus granulosus transient receptor potential cation channel 0.0043 0.0014 0.0018
Echinococcus granulosus ring and YY1 binding protein 0.0059 0.0055 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0087 0.0128 0.2113
Schistosoma mansoni tyrosine kinase 0.0045 0.0021 0.0023
Onchocerca volvulus 0.0038 0.0003 0.0018
Echinococcus multilocularis ryanodine receptor 44f 0.0043 0.0014 0.0018
Trypanosoma brucei trypanothione reductase 0.0098 0.0156 0.1772
Leishmania major trypanothione reductase 0.0098 0.0156 0.1354
Brugia malayi olfactory channel protein osm-9 0.0043 0.0014 0.002
Schistosoma mansoni hypothetical protein 0.0309 0.0706 0.0763
Echinococcus granulosus voltage dependent calcium channel 0.0149 0.029 0.0388
Brugia malayi hypothetical protein 0.0038 0.0003 0.0004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0223 0.0481 0.0366
Mycobacterium tuberculosis Probable reductase 0.0223 0.0481 0.0366
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0003 0.0004
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.0021 0.0028
Brugia malayi proprotein convertase 2 0.009 0.0136 0.0197
Trypanosoma brucei heat shock protein 90, putative 0.0139 0.0264 0.301
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.0021 0.0028
Loa Loa (eye worm) hypothetical protein 0.0115 0.0201 0.0292

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 15 nM Enzyme inhibitory activity against recombinant human Src protein tryrosine kinase ChEMBL. 15080999
IC50 (binding) = 15 nM Enzyme inhibitory activity against recombinant human Src protein tryrosine kinase ChEMBL. 15080999
IC50 (functional) = 0.23 uM Inhibitory activity against Src-dependent cell proliferation assay using rat fibroblasts ChEMBL. 15080999

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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