TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.61 | Formula: C28H36N4O3
H donors: 1 H acceptors: 1 LogP: 3.93 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)cccc1N1CCN(CC1)CCCNC(=O)c1cc(n(c1C)C)c1ccccc1
InChi: 1S/C28H36N4O3/c1-21-23(20-25(30(21)2)22-10-6-5-7-11-22)28(33)29-14-9-15-31-16-18-32(19-17-31)24-12-8-13-26(34-3)27(24)35-4/h5-8,10-13,20H,9,14-19H2,1-4H3,(H,29,33)
InChiKey: CZXBPXYQHYAPBF-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 6 (neurotransmitter transporter), member 4	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	Starlite/ChEMBL	References
Homo sapiens	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Serotonin receptor	Get druggable targets OG5_135430	All targets in OG5_135430
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Sodium:neurotransmitter symporter family protein	solute carrier family 6 (neurotransmitter transporter), member 4	630 aa	574 aa	31.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase	0.0074	0.0448	0.0676
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0074	0.045	0.068
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0069	0.0407	0.0615
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0013	0.0045
Schistosoma mansoni	glutaminase	0.0295	0.2286	0.8012
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0013	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0013	0.0019
Echinococcus granulosus	zinc finger protein	0.0023	0.0021	0.0032
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0532	0.0494
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0203	0.0307
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0013	0.0019
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0044	0.0196	0.0963
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0031	0.0089	0.0539
Onchocerca volvulus		0.0074	0.0448	0.3103
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0031	0.0089	0.0539
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0013	0.0045
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0119	0.0822	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0817	0.662	1
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0448	0.0676
Brugia malayi	RNA recognition motif domain containing protein	0.0054	0.0284	0.0429
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0074	0.0448	0.0676
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0013	0.0019
Plasmodium falciparum	glutathione reductase	0.0037	0.0139	0.1272
Echinococcus granulosus	intermediate filament protein	0.0041	0.0177	0.0268
Echinococcus granulosus	tumor protein p63	0.0391	0.3085	0.4659
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0448	0.1957
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0028	0.0063	0.0284
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0156	0.0545
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0013	0.0019
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0013	0.0019
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0013	0.0088
Loa Loa (eye worm)	bromodomain containing protein	0.002	0.0003	0.0004
Echinococcus multilocularis	neutral alpha glucosidase AB	0.0074	0.045	0.068
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0599	0.0906
Onchocerca volvulus	Huntingtin homolog	0.0162	0.118	0.8185
Trichomonas vaginalis	phosphofructokinase, putative	0.0074	0.0447	0.1955
Onchocerca volvulus		0.0167	0.1217	0.8439
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0013	0.0045
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0031	0.0089	0.0539
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0448	0.2698
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0448	0.0676
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0013	0.0019
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0156	0.0235
Plasmodium vivax	hypothetical protein, conserved	0.0074	0.0448	0.5212
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0092	0.0599	0.0906
Brugia malayi	steroid hormone receptor	0.0022	0.0013	0.0019
Loa Loa (eye worm)	glutaminase	0.0295	0.2286	0.3454
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.005	0.0174
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0013	0.0019
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0042	0.0178	0.0269
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0013	0.0019
Trichomonas vaginalis	alpha-glucosidase, putative	0.0074	0.045	0.1969
Brugia malayi	phosphofructokinase	0.0074	0.0447	0.0675
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0074	0.045	0.1969
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0028	0.0063	0.0377
Onchocerca volvulus		0.0194	0.1442	1
Echinococcus multilocularis	tumor protein p63	0.0391	0.3085	0.4659
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.2201	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0044	0.0196	0.1179
Schistosoma mansoni	6-phosphofructokinase	0.0074	0.0447	0.1566
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0013	0.0019
Giardia lamblia	Kinase, CMGC MAPK	0.0044	0.0196	0.0888
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0122	0.0848	0.2972
Trypanosoma cruzi	glycosyl hydrolase-like protein, putative	0.0028	0.0063	0.0377
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0119	0.0822	0.0786
Schistosoma mansoni	lamin	0.0041	0.0177	0.0621
Schistosoma mansoni	sodium/chloride dependent transporter	0.0073	0.0439	0.154
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0532	0.0494
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0904	0.1366
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0092	0.0599	0.0906
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0119	0.0822	1
Loa Loa (eye worm)	beta-lactamase	0.0074	0.0448	0.0676
Echinococcus granulosus	neuropeptide s receptor	0.0308	0.2392	0.3613
Echinococcus granulosus	lamin	0.0041	0.0177	0.0268
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0054	0.0284	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0171	0.0258
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0119	0.0822	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0041	0.0177	0.0268
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0119	0.0822	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0074	0.0447	0.0675
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.005	0.0075
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0139	0.1272
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0532	0.0494
Echinococcus multilocularis	lamin dm0	0.0041	0.0177	0.0268
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0209	0.1569	0.2371
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0532	0.0494
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0047	0.0226	0.0341
Brugia malayi	glutathione reductase	0.0037	0.0139	0.021
Mycobacterium tuberculosis	Probable lipase LipE	0.0074	0.0448	0.041
Brugia malayi	nuclear hormone receptor	0.0022	0.0013	0.0019
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0284	0.0995
Echinococcus granulosus	6 phosphofructokinase	0.0074	0.0447	0.0675
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0116	0.0794	0.0758
Echinococcus granulosus	lamin dm0	0.0041	0.0177	0.0268
Trypanosoma brucei	glucosidase, putative	0.0074	0.045	0.2536
Leishmania major	hypothetical protein, conserved	0.0074	0.0448	0.252
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.0448	0.2698
Brugia malayi	intermediate filament protein	0.0041	0.0177	0.0268
Onchocerca volvulus		0.0057	0.0309	0.214
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0025	0.004	0.0481
Schistosoma mansoni	cellular tumor antigen P53	0.0057	0.0309	0.1081
Trichomonas vaginalis	esterase, putative	0.0074	0.0448	0.1957
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0013	0.0019
Brugia malayi	hypothetical protein	0.0039	0.0156	0.0235
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0532	0.0494
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0139	0.021
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0203	0.0307
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0013	0.0019
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0028	0.0063	0.0274
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0013	0.0019
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0284	0.0995
Mycobacterium ulcerans	beta-lactamase	0.0074	0.0448	0.041
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0119	0.0822	0.0786
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0013	0.0019
Leishmania major	ATP-dependent phosphofructokinase	0.0074	0.0447	0.2516
Echinococcus granulosus	metabotropic glutamate receptor 2	0.009	0.0581	0.0877
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0284	0.0995
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0074	0.0448	0.0676
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0203	0.0712
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0139	0.1692
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0013	0.0045
Schistosoma mansoni	6-phosphofructokinase	0.0074	0.0447	0.1566
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0119	0.0822	1
Echinococcus granulosus	geminin	0.0363	0.2854	0.431
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.045	0.2714
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0243	0.0367
Mycobacterium ulcerans	hypothetical protein	0.0074	0.0448	0.041
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0044	0.0196	0.0963
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0044	0.0196	0.1179
Echinococcus multilocularis	neuropeptide receptor A26	0.0308	0.2392	0.3613
Echinococcus granulosus	tar DNA binding protein	0.0054	0.0284	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0202	0.0305
Trichomonas vaginalis	glutaminase, putative	0.0295	0.2286	1
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0932	0.1408
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0013	0.0019
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0013	0.0019
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0448	0.1957
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0074	0.045	0.1969
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0139	0.099	0.0954
Schistosoma mansoni	hypothetical protein	0.0024	0.0031	0.0109
Schistosoma mansoni	hypothetical protein	0.0167	0.1217	0.4265
Brugia malayi	Bromodomain containing protein	0.0044	0.0201	0.0304
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0074	0.045	0.1969
Brugia malayi	follicle stimulating hormone receptor	0.0209	0.1569	0.2371
Mycobacterium ulcerans	glutaminase	0.0295	0.2286	0.2256
Trichomonas vaginalis	alpha-glucosidase, putative	0.0074	0.045	0.1969
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0203	0.0307
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Entamoeba histolytica	hypothetical protein	0.0039	0.0156	0.0707
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0013	0.0019
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0013	0.0045
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0203	0.0307
Loa Loa (eye worm)	norepinephrine transporter	0.0073	0.0439	0.0664
Entamoeba histolytica	phosphofructokinase, putative	0.0074	0.0447	0.203
Schistosoma mansoni	serine/threonine protein kinase	0.0044	0.0196	0.0685
Mycobacterium leprae	conserved hypothetical protein	0.0074	0.0448	0.041
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0448	0.041
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0028	0.0062	0.0093
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0139	0.1272
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0139	0.099	0.0954
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0013	0.0019
Mycobacterium leprae	Probable lipase LipE	0.0074	0.0448	0.041
Trypanosoma cruzi	hypothetical protein, conserved	0.0074	0.045	0.2714
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0013	0.0019
Loa Loa (eye worm)	glutamate receptor	0.0107	0.0726	0.1096
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0074	0.045	0.1969
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Brugia malayi	Serotonin receptor	0.0567	0.4549	0.6871
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0031	0.0089	0.0307
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0074	0.045	0.2045
Brugia malayi	Receptor family ligand binding region containing protein	0.0028	0.0062	0.0093
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0013	0.0045
Trichomonas vaginalis	phosphofructokinase, putative	0.0074	0.0447	0.1955
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0073	0.0439	0.0664
Mycobacterium tuberculosis	Transcriptional regulatory repressor protein (TetR-family) EthR	0.1223	1	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0013	0.0019
Brugia malayi	hypothetical protein	0.0817	0.662	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0063	0.0274
Schistosoma mansoni	intermediate filament proteins	0.0041	0.0177	0.0621
Onchocerca volvulus		0.0073	0.0439	0.3047
Brugia malayi	ecdysteroid receptor	0.0022	0.0013	0.0019
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0013	0.0045
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0013	0.0045
Schistosoma mansoni	alpha-glucosidase	0.0288	0.2228	0.7807
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0044	0.0196	0.0963
Entamoeba histolytica	phosphofructokinase, putative	0.0074	0.0447	0.203
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0013	0.0019
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0139	0.1272
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0532	0.0494
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0028	0.0062	0.0093
Onchocerca volvulus		0.0163	0.1189	0.8245
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0335	0.2615	0.3951
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0092	0.0599	0.2101
Schistosoma mansoni	lamin	0.0041	0.0177	0.0621
Brugia malayi	hypothetical protein	0.0163	0.1189	0.1796
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0063	0.0095
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0013	0.0019
Brugia malayi	metabotropic glutamate receptor type 2	0.0052	0.0268	0.0405
Mycobacterium tuberculosis	Probable hydrolase	0.0074	0.0448	0.041
Entamoeba histolytica	phosphofructokinase, putative	0.0074	0.0447	0.203
Echinococcus granulosus	neuropeptide receptor A26	0.0308	0.2392	0.3613
Mycobacterium ulcerans	esterase/lipase LipP	0.0074	0.0448	0.041
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0335	0.2615	0.3951
Trichomonas vaginalis	CMGC family protein kinase	0.0044	0.0196	0.0855
Onchocerca volvulus		0.0089	0.0569	0.3942
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0089	0.0569	0.0859
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0074	0.0447	0.0409
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0139	0.099	0.0954
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0063	0.0274
Schistosoma mansoni	hypothetical protein	0.0039	0.0156	0.0545
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0062	0.0093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0203	0.0712
Trypanosoma brucei	glycosyl hydrolase-like protein	0.0028	0.0063	0.0142
Onchocerca volvulus		0.0074	0.0448	0.3103
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0074	0.0448	0.041
Echinococcus multilocularis	lamin	0.0041	0.0177	0.0268
Entamoeba histolytica	hypothetical protein	0.0039	0.0156	0.0707
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0063	0.0274
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0285	0.2201	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.061	0.0573
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0074	0.045	0.068
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0139	0.0839
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0028	0.0063	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0439	0.0664
Trichomonas vaginalis	CMGC family protein kinase	0.0044	0.0196	0.0855
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0104	0.0697	0.4059
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0073	0.0439	0.0664
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.022	0.1659	1
Treponema pallidum	fructose-bisphosphate aldolase	0.0285	0.2201	1
Trichomonas vaginalis	CMGC family protein kinase	0.0044	0.0196	0.0855
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0013	0.0019
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0044	0.0196	0.1179
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0013	0.0019
Onchocerca volvulus		0.0041	0.0177	0.1228
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0073	0.0439	0.154
Loa Loa (eye worm)	cytochrome P450 family protein	0.0031	0.0093	0.0141
Schistosoma mansoni	alpha-glucosidase	0.0288	0.2228	0.7807
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0448	0.0676
Mycobacterium ulcerans	AcrR family transcriptional regulator	0.1223	1	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0028	0.0063	0.0274
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0044	0.0196	0.0295
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0013	0.0019
Echinococcus multilocularis	mitogen activated protein kinase	0.0044	0.0196	0.0295
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0044	0.0196	0.2378
Loa Loa (eye worm)	hypothetical protein	0.0163	0.1189	0.1796
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0104	0.0697	0.4059
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0089	0.0569	0.1992
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0448	0.1957
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0104	0.0697	0.4201
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0448	0.0676
Echinococcus multilocularis	serotonin transporter	0.0073	0.0439	0.0664
Onchocerca volvulus	Huntingtin homolog	0.0162	0.118	0.8185
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0139	0.01
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0013	0.0019
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Leishmania major	trypanothione reductase	0.0037	0.0139	0.0615
Brugia malayi	glutaminase DH11.1	0.0295	0.2286	0.3454
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0473	0.3762	0.3737
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0013	0.0019
Schistosoma mansoni	coup transcription factor	0.0022	0.0013	0.0045
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0013	0.0088
Loa Loa (eye worm)	6-phosphofructokinase	0.0074	0.0447	0.0675
Echinococcus multilocularis	zinc finger protein	0.0023	0.0021	0.0032
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.061	0.0573
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0013	0.0088
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0139	0.021
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0013	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0162	0.118	0.1783
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0047	0.0226	0.0341
Loa Loa (eye worm)	glutamate receptor	0.0042	0.0184	0.0278
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0132	0.0932	0.1408
Brugia malayi	MAP kinase sur-1	0.0044	0.0196	0.0295
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0013	0.0019
Schistosoma mansoni	alpha glucosidase	0.0074	0.045	0.1577
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0448	0.041
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0904	0.1366
Mycobacterium ulcerans	TetR family transcriptional regulator	0.1223	1	1
Entamoeba histolytica	hypothetical protein	0.0025	0.004	0.018
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.022	0.1659	1
Brugia malayi	Thioredoxin reductase	0.0037	0.0139	0.021
Echinococcus multilocularis	survival motor neuron protein 1	0.0817	0.662	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0063	0.0274
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0013	0.0019
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0022	0.0017	0.0026
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0097	0.0642	0.0969
Schistosoma mansoni	bromodomain containing protein	0.0073	0.0442	0.1548
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0177	0.0268
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0013	0.0045
Echinococcus multilocularis	geminin	0.0363	0.2854	0.431
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0069	0.0407	0.0615
Echinococcus granulosus	mitogen activated protein kinase 3	0.0044	0.0196	0.0295
Mycobacterium tuberculosis	Probable lipase LipD	0.0074	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0439	0.0664
Mycobacterium tuberculosis	Conserved protein	0.0074	0.0448	0.041
Trichomonas vaginalis	alpha-glucosidase, putative	0.0028	0.0063	0.0274
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0089	0.0569	0.0859
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0335	0.2615	0.3951
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0532	0.0494
Mycobacterium ulcerans	lipase LipD	0.0074	0.0448	0.041
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0167	0.1217	0.1838
Schistosoma mansoni	survival motor neuron protein	0.0167	0.1217	0.4265
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0203	0.0307
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0031	0.0047
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0074	0.0447	0.1884
Schistosoma mansoni	hypothetical protein	0.0363	0.2854	1
Entamoeba histolytica	hypothetical protein	0.0039	0.0156	0.0707
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0092	0.0599	0.0906
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0203	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0513	0.0775
Trichomonas vaginalis	penicillin-binding protein, putative	0.0074	0.0448	0.1957
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0599	0.0906
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0013	0.0019
Brugia malayi	hypothetical protein	0.0162	0.118	0.1783
Trypanosoma brucei	trypanothione reductase	0.0037	0.0139	0.0615
Brugia malayi	beta-lactamase family protein	0.0074	0.0448	0.0676
Brugia malayi	Intermediate filament tail domain containing protein	0.0041	0.0177	0.0268
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0025	0.004	0.0481
Brugia malayi	PHD-finger family protein	0.0029	0.0072	0.0109
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0074	0.0448	0.041
Onchocerca volvulus	Uncharacterized family 31 glucosidase KIAA1161 homolog	0.0028	0.0063	0.0434
Brugia malayi	RNA binding protein	0.0054	0.0284	0.0429
Echinococcus multilocularis	6 phosphofructokinase	0.0074	0.0447	0.0675
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0309	0.0466
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0013	0.0019
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0074	0.0447	0.0409
Brugia malayi	Bromodomain containing protein	0.0087	0.0554	0.0837
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0284	0.0995
Brugia malayi	MH2 domain containing protein	0.0129	0.0904	0.1366
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0132	0.0932	0.1408
Trichomonas vaginalis	D-aminoacylase, putative	0.0074	0.0448	0.1957
Mycobacterium tuberculosis	Probable esterase LipL	0.0074	0.0448	0.041
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0013	0.0045
Schistosoma mansoni	metabotropic glutamate receptor	0.0052	0.0268	0.0939
Brugia malayi	6-phosphofructokinase	0.0074	0.0447	0.0675
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0074	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0162	0.118	0.1783
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0335	0.2615	0.3951
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.005	0.0075
Onchocerca volvulus		0.0041	0.0177	0.1228
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.061	0.0573
Echinococcus granulosus	beta LACTamase domain containing family member	0.0074	0.0448	0.0676
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0074	0.0448	0.0676
Toxoplasma gondii	hypothetical protein	0.0035	0.0127	0.1545
Echinococcus multilocularis	tar DNA binding protein	0.0054	0.0284	0.0429
Brugia malayi	TAR-binding protein	0.0054	0.0284	0.0429
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.059	0.4735	0.7153
Schistosoma mansoni	hypothetical protein	0.0363	0.2854	1
Mycobacterium ulcerans	hypothetical protein	0.0116	0.0794	0.0758
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.061	0.0573
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0013	0.0019
Loa Loa (eye worm)	phosphofructokinase	0.0074	0.0447	0.0675
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0074	0.0448	0.041
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0599	0.0906
Brugia malayi	6-phosphofructokinase	0.0074	0.0447	0.0675
Onchocerca volvulus		0.0022	0.0013	0.0088
Trichomonas vaginalis	hypothetical protein	0.0119	0.0822	0.3597
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0013	0.0019
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0042	0.0178	0.0269
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0074	0.0447	0.2516
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0143	0.0216
Mycobacterium ulcerans	6-phosphofructokinase	0.0074	0.0447	0.0409
Loa Loa (eye worm)	TAR-binding protein	0.0054	0.0284	0.0429
Giardia lamblia	Fructose-bisphosphate aldolase	0.0285	0.2201	1
Loa Loa (eye worm)	intermediate filament protein	0.0041	0.0177	0.0268
Leishmania major	alpha glucosidase II subunit, putative	0.0074	0.045	0.2536
Trypanosoma brucei	hypothetical protein, conserved	0.0074	0.0448	0.252
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0448	0.0676
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0143	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0013	0.0019
Trichomonas vaginalis	alpha-glucosidase, putative	0.0074	0.045	0.1969
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0013	0.0045
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0013	0.0019
Schistosoma mansoni	zinc finger protein	0.0023	0.0021	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0569	0.0859
Echinococcus granulosus	lysosomal alpha glucosidase	0.0335	0.2615	0.3951
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0013	0.0019
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0448	0.1568
Onchocerca volvulus		0.0074	0.0448	0.3103
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0074	0.0448	0.1568
Echinococcus granulosus	neutral alpha glucosidase AB	0.0074	0.045	0.068
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0013	0.0045
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0119	0.0822	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0439	0.0664
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0074	0.0447	0.2695
Mycobacterium ulcerans	transcriptional regulator	0.1223	1	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.022	0.1659	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0013	0.0019
Brugia malayi	beta-lactamase family protein	0.0074	0.0448	0.0676
Brugia malayi	cytoplasmic intermediate filament protein	0.0022	0.0017	0.0026
Leishmania major	mitochondrial DNA polymerase beta	0.022	0.1659	1
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0028	0.0063	0.0274
Echinococcus multilocularis	neuropeptide s receptor	0.0308	0.2392	0.3613
Trichomonas vaginalis	phosphofructokinase, putative	0.0074	0.0447	0.1955
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0203	0.0712
Schistosoma mansoni	metabotropic glutamate receptor	0.009	0.0581	0.2035
Echinococcus granulosus	L aminoadipate semialdehyde	0.0089	0.0569	0.0859
Trypanosoma brucei	protein kinase, putative	0.0044	0.0196	0.0963
Schistosoma mansoni	lipoxygenase	0.0047	0.0226	0.0791
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0448	0.0676
Entamoeba histolytica	hypothetical protein	0.0039	0.0156	0.0707
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0013	0.0019
Trichomonas vaginalis	alpha-glucosidase, putative	0.0074	0.045	0.1969
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0225	0.0339
Echinococcus granulosus	serotonin transporter	0.0073	0.0439	0.0664
Loa Loa (eye worm)	RNA binding protein	0.0054	0.0284	0.0429
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0013	0.0019
Trichomonas vaginalis	alpha-glucosidase, putative	0.0074	0.045	0.1969
Leishmania major	glycosyl hydrolase-like protein	0.0028	0.0063	0.0142
Loa Loa (eye worm)	serotonin transporter b	0.0073	0.0439	0.0664
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0074	0.045	0.2045
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0074	0.045	0.5473
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0044	0.0196	0.1179
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.009	0.0581	0.0877
Toxoplasma gondii	ABC1 family protein	0.0074	0.0448	0.5442
Schistosoma mansoni	tar DNA-binding protein	0.0054	0.0284	0.0995
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0038	0.0145	0.0877
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0044	0.0196	0.0295
Echinococcus granulosus	mitogen activated protein kinase	0.0044	0.0196	0.0295
Trichomonas vaginalis	CMGC family protein kinase	0.0044	0.0196	0.0855
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0013	0.0019
Brugia malayi	Cytochrome P450 family protein	0.0031	0.0093	0.0141
Treponema pallidum	sodium- and chloride- dependent transporter	0.0073	0.0439	0.185
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0107	0.0726	0.1096
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0285	0.2201	0.9627
Echinococcus granulosus	survival motor neuron protein 1	0.0817	0.662	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0156	0.0235
Echinococcus multilocularis	musashi	0.0041	0.0177	0.0268
Loa Loa (eye worm)	glutaminase 2	0.0295	0.2286	0.3454
Trichomonas vaginalis	phosphofructokinase, putative	0.0074	0.0447	0.1955

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 666 nM	Displacement of [3H]ketanserin from human recombinant 5HT2A expressed in CHOK1 cells	ChEMBL.	20637635
IC50 (binding)	= 782 nM	Displacement of [3H]mesulergine from human recombinant 5HT2C expressed in CHOK1 cells	ChEMBL.	20637635
IC50 (binding)	= 1259 nM	Displacement of [3H]imipramine from human SERT expressed in HEK293 cells	ChEMBL.	20637635

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1213932

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1155103