Detailed information for compound 1164109

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.306 | Formula: C17H15NO3
  • H donors: 1 H acceptors: 2 LogP: 3.3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc2c(o1)cc(c(c2)c1ccc(cc1)N(C)C)O
  • InChi: 1S/C17H15NO3/c1-18(2)13-6-3-11(4-7-13)14-9-12-5-8-17(20)21-16(12)10-15(14)19/h3-10,19H,1-2H3
  • InChiKey: IEIHLHMWHWSYKM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0643 0.1587
Loa Loa (eye worm) hypothetical protein 0.0055 0.0596 0.1754
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0145 0.0134
Loa Loa (eye worm) hypothetical protein 0.0154 0.1854 0.5586
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0172 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0473 0.138
Mycobacterium tuberculosis Conserved protein 0.0114 0.1348 0.1339
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0279 0.0414
Onchocerca volvulus 0.0055 0.0596 0.2112
Mycobacterium tuberculosis Conserved protein 0.0114 0.1348 0.1339
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0547 0.1024
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0145 0.0276
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0145 0.0276
Schistosoma mansoni thyroid hormone receptor 0.0009 0.002 0.0038
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0749 0.1409
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0643 0.1587
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0085 0.0257
Plasmodium falciparum peptide deformylase 0.0225 0.2754 1
Schistosoma mansoni myst-related protein 0.0008 0.0001 0.0002
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0391 0.1131
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2822 0.8529
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0114 0.1348 0.1339
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0895 0.1687
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.0991 0.7034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.1118 0.3385
Echinococcus multilocularis tar DNA binding protein 0.0127 0.1515 0.1506
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0172 0.0464
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0643 0.1587
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.028 0.0791
Loa Loa (eye worm) RNA binding protein 0.0127 0.1515 0.4554
Brugia malayi CXXC zinc finger family protein 0.003 0.028 0.0846
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.002 0.0071
Brugia malayi Bromodomain containing protein 0.0084 0.096 0.2907
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.1515 0.4554
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0058 0.0643 0.4139
Echinococcus granulosus polycomb protein SCMH1 0.0055 0.0596 0.1117
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0122
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0749 0.0739
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.002 0.0009
Echinococcus multilocularis lamin dm0 0.0027 0.024 0.0229
Schistosoma mansoni lamin 0.0027 0.024 0.0457
Brugia malayi beta-lactamase 0.0114 0.1348 0.4082
Schistosoma mansoni bromodomain containing protein 0.014 0.167 0.3182
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.002 0.0038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0266 0.3263 0.9877
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0172 0.003
Loa Loa (eye worm) hypothetical protein 0.0183 0.2222 0.6707
Loa Loa (eye worm) hypothetical protein 0.0019 0.0145 0.0381
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.002 0.0017
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0895 0.0885
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0145 0.0439
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0145 0.0256
Schistosoma mansoni nuclear hormone receptor 0.0009 0.002 0.0038
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.002 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0127 0.1515 0.4554
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.002 0.0017
Brugia malayi RNA binding protein 0.0127 0.1515 0.4587
Schistosoma mansoni myelin transcription factor 1 myt1 0.0062 0.0692 0.1318
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0114 0.1348 0.4046
Mycobacterium ulcerans lipase LipD 0.0114 0.1348 0.3834
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.0991 0.7034
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.002 0.0009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1348 0.2569
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.002 0.006
Toxoplasma gondii ABC1 family protein 0.0114 0.1348 0.4556
Echinococcus multilocularis SAM and MBT domain containing protein 0.0055 0.0596 0.0586
Echinococcus granulosus cpg binding protein 0.0036 0.0354 0.0654
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0172 0.0522
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0034 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0172 0.0227
Schistosoma mansoni thyroid hormone receptor 0.0009 0.002 0.0038
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0172 0.0622
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1348 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0062 0.0692 0.0681
Echinococcus granulosus histone acetyltransferase MYST2 0.0062 0.0692 0.1299
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0183 0.2222 0.6727
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.002 0.0017
Echinococcus multilocularis mitogen activated protein kinase 3 0.0058 0.0643 0.0633
Loa Loa (eye worm) beta-lactamase 0.0114 0.1348 0.4046
Echinococcus granulosus intermediate filament protein 0.0027 0.024 0.0437
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1515 0.2886
Loa Loa (eye worm) histone methyltransferase 0.001 0.0034 0.0042
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0374 0.0694
Onchocerca volvulus 0.0114 0.1348 0.4778
Loa Loa (eye worm) MBCTL1 0.0062 0.0692 0.2046
Schistosoma mansoni hypothetical protein 0.0045 0.0473 0.0901
Echinococcus granulosus tar DNA binding protein 0.0127 0.1515 0.2871
Leishmania major polypeptide deformylase-like protein, putative 0.0086 0.0991 0.7034
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.1572 0.2979
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.4046
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0145 0.0134
Echinococcus multilocularis geminin 0.0175 0.2119 0.211
Echinococcus multilocularis dna polymerase eta 0.0019 0.0145 0.0134
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0058 0.0643 0.4139
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.002 0.0009
Onchocerca volvulus 0.003 0.0279 0.0989
Brugia malayi mbt repeat family protein 0.0055 0.0596 0.1804
Echinococcus multilocularis cpg binding protein 0.0036 0.0354 0.0343
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0066 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.002 0.006
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0062 0.0692 0.2094
Echinococcus granulosus SAM and MBT domain containing protein 0.0055 0.0596 0.1117
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0058 0.0643 0.1898
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.002 0.006
Brugia malayi PHD-finger family protein 0.0056 0.0612 0.1854
Schistosoma mansoni zinc finger protein 0.0044 0.0465 0.0886
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0055 0.0596 0.2112
Mycobacterium tuberculosis Probable esterase LipL 0.0114 0.1348 0.1339
Loa Loa (eye worm) hypothetical protein 0.0027 0.024 0.067
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.4046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0749 0.1427
Schistosoma mansoni hypothetical protein 0.0055 0.0598 0.1138
Schistosoma mansoni hypothetical protein 0.0175 0.2119 0.4036
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.1572 0.1562
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.002 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Echinococcus granulosus dnaJ subfamily B 0.0423 0.525 1
Schistosoma mansoni hypothetical protein 0.0423 0.525 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0058 0.0643 0.1824
Onchocerca volvulus Huntingtin homolog 0.0127 0.1505 0.5334
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.024 0.067
Mycobacterium ulcerans hypothetical protein 0.0114 0.1348 0.3834
Echinococcus multilocularis mitogen activated protein kinase 0.0058 0.0643 0.0633
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.4046
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.024 0.0727
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0145 0.0585
Loa Loa (eye worm) hypothetical protein 0.0127 0.1505 0.4524
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0279 0.0268
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0172 0.0227
Echinococcus granulosus mitogen activated protein kinase 3 0.0058 0.0643 0.1207
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.4046
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.002 0.0009
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0145 0.0439
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1348 0.3834
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.002 0.006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.073 0.9131 1
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1348 0.3834
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0172 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0178 0.2159 0.6416
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0072
Brugia malayi mbt repeat family protein 0.0055 0.0596 0.1804
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0145 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.002 0.006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0114 0.1348 0.1339
Schistosoma mansoni coup transcription factor 0.0009 0.002 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.002 0.0009
Schistosoma mansoni serine/threonine protein kinase 0.0058 0.0643 0.1225
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.0991 0.7034
Loa Loa (eye worm) hypothetical protein 0.0067 0.0749 0.2221
Trypanosoma brucei Polypeptide deformylase 1 0.0086 0.0991 0.7207
Echinococcus granulosus mitogen activated protein kinase 0.0058 0.0643 0.1207
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0547 0.1042
Schistosoma mansoni glutaminase 0.0267 0.3284 0.6256
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0145 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.1118 0.3345
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.002 0.0009
Schistosoma mansoni ap endonuclease 0.0021 0.0172 0.0328
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0257 0.047
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0058 0.0643 0.4139
Schistosoma mansoni bromodomain containing protein 0.0011 0.0044 0.0083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0172 0.0227
Trypanosoma brucei Peptide deformylase 2 0.0086 0.0991 0.7207
Loa Loa (eye worm) hypothetical protein 0.0095 0.1101 0.3294
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.002 0.0038
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.0991 0.7034
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0596 0.1135
Toxoplasma gondii hypothetical protein 0.0225 0.2754 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0145 0.0585
Mycobacterium tuberculosis Conserved protein 0.0114 0.1348 0.1339
Brugia malayi Bromodomain containing protein 0.0165 0.1993 0.6034
Mycobacterium ulcerans glutaminase 0.0267 0.3284 1
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1348 0.3834
Echinococcus granulosus dna polymerase eta 0.0019 0.0145 0.0256
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0062 0.0692 0.0681
Mycobacterium ulcerans esterase/lipase LipP 0.0114 0.1348 0.3834
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0172 0.0547
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0279 0.0532
Loa Loa (eye worm) hypothetical protein 0.0269 0.3303 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.0145 0.0256
Loa Loa (eye worm) glutaminase 0.0267 0.3284 0.9941
Onchocerca volvulus Huntingtin homolog 0.0127 0.1505 0.5334
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0058 0.0643 0.4139
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1515 0.2886
Echinococcus multilocularis zinc finger protein 0.0044 0.0465 0.0455
Schistosoma mansoni sex comb on midleg homolog 0.0055 0.0596 0.1135
Echinococcus granulosus geminin 0.0175 0.2119 0.4023
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.002 0.006
Echinococcus multilocularis musashi 0.0027 0.024 0.0229
Schistosoma mansoni myst-related protein 0.0008 0.0001 0.0002
Brugia malayi intermediate filament protein 0.0027 0.024 0.0727
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.4046
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.002 0.0071
Onchocerca volvulus 0.0027 0.024 0.085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.002 0.0009
Schistosoma mansoni survival motor neuron protein 0.0055 0.0598 0.1138
Trypanosoma brucei protein kinase, putative 0.0058 0.0643 0.4482
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0011 0.0021
Trypanosoma brucei ISWI complex protein 0.0033 0.0326 0.2001
Chlamydia trachomatis peptide deformylase 0.0225 0.2754 0.5
Trichomonas vaginalis penicillin-binding protein, putative 0.0114 0.1348 0.3834
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0145 0.8407
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.002 0.006
Onchocerca volvulus 0.0027 0.024 0.085
Schistosoma mansoni intermediate filament proteins 0.0027 0.024 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.002 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0234 0.0651
Onchocerca volvulus 0.003 0.028 0.0991
Brugia malayi ecdysteroid receptor 0.0009 0.002 0.006
Trichomonas vaginalis D-aminoacylase, putative 0.0114 0.1348 0.3834
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0172 0.0162
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0062 0.0692 0.1299
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.002 0.0017
Plasmodium vivax SET domain protein, putative 0.003 0.0279 0.0414
Onchocerca volvulus 0.0231 0.2822 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.002 0.0071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0749 0.1427
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.002 0.0038
Brugia malayi steroid hormone receptor 0.0009 0.002 0.006
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.022 0.2684 0.2676
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0225 0.2754 1
Trypanosoma cruzi hypothetical protein, conserved 0.0114 0.1348 1
Mycobacterium tuberculosis Probable lipase LipE 0.0114 0.1348 0.1339
Echinococcus multilocularis beta LACTamase domain containing family member 0.0114 0.1348 0.1339
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.002 0.006
Schistosoma mansoni zinc finger protein 0.0033 0.0326 0.0621
Brugia malayi follicle stimulating hormone receptor 0.0266 0.3263 0.9878
Trypanosoma cruzi ISWI complex protein 0.0033 0.0326 0.1504
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1118 0.213
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0694 0.2021
Mycobacterium tuberculosis Probable lipase LipD 0.0114 0.1348 0.1339
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0066 0.0106
Mycobacterium ulcerans beta-lactamase 0.0114 0.1348 0.3834
Loa Loa (eye worm) hypothetical protein 0.0089 0.1027 0.3068
Schistosoma mansoni cpg binding protein 0.0036 0.0354 0.0674
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1118 0.2114
Brugia malayi glutaminase DH11.1 0.0267 0.3284 0.9941
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0547 0.0537
Loa Loa (eye worm) mbt repeat family protein 0.0055 0.0596 0.1754
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0279 0.0532
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.002 0.0017
Brugia malayi Pre-SET motif family protein 0.003 0.0279 0.0845
Loa Loa (eye worm) hypothetical protein 0.0012 0.006 0.0122
Onchocerca volvulus 0.0055 0.0598 0.2117
Echinococcus granulosus beta LACTamase domain containing family member 0.0114 0.1348 0.2553
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.002 0.006
Echinococcus multilocularis lamin 0.0027 0.024 0.0229
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1118 0.213
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.002 0.0038
Schistosoma mansoni hypothetical protein 0.0175 0.2119 0.4036
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.002 0.006
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0034 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.002 0.006
Brugia malayi nuclear hormone receptor 0.0009 0.002 0.006
Brugia malayi nuclear receptor NHR-88 0.0009 0.002 0.006
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.002 0.006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0172 0.0308
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0058 0.0643 0.4482
Trypanosoma brucei hypothetical protein, conserved 0.0114 0.1348 1
Trichomonas vaginalis glutaminase, putative 0.0267 0.3284 1
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1515 0.2886
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.002 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2469 0.7459
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0114 0.1348 0.1339
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0225 0.2754 1
Echinococcus granulosus lamin 0.0027 0.024 0.0437
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0145 0.0585
Schistosoma mansoni ap endonuclease 0.0021 0.0172 0.0328
Schistosoma mansoni cpg binding protein 0.003 0.028 0.0533
Schistosoma mansoni hypothetical protein 0.0337 0.4163 0.7931
Brugia malayi Pre-SET motif family protein 0.0203 0.2469 0.7474
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.002 0.0038
Giardia lamblia Kinase, CMGC MAPK 0.0058 0.0643 1
Trypanosoma cruzi ISWI complex protein 0.0033 0.0326 0.1504
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.002 0.006
Schistosoma mansoni DNA polymerase eta 0.0019 0.0145 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.1118 0.213
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0084 0.0195
Trichomonas vaginalis CMGC family protein kinase 0.0058 0.0643 0.1587
Echinococcus multilocularis polycomb protein SCMH1 0.0055 0.0596 0.0586
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.525 0.5244
Echinococcus granulosus FTZ F1 alpha 0.0009 0.002 0.0017
Onchocerca volvulus 0.0114 0.1348 0.4778
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0114 0.1348 0.3834
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.002 0.0038
Brugia malayi beta-lactamase family protein 0.0114 0.1348 0.4082
Trichomonas vaginalis esterase, putative 0.0114 0.1348 0.3834
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0172 0.0798
Brugia malayi hypothetical protein 0.0269 0.3303 1
Plasmodium vivax hypothetical protein, conserved 0.0114 0.1348 0.4556
Loa Loa (eye worm) hypothetical protein 0.0062 0.0692 0.2046
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.002 0.0038
Leishmania major hypothetical protein, conserved 0.0114 0.1348 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.1118 0.2114
Echinococcus granulosus zinc finger protein 0.0044 0.0465 0.0867
Loa Loa (eye worm) glutaminase 2 0.0267 0.3284 0.9941
Loa Loa (eye worm) hypothetical protein 0.0084 0.0962 0.2869
Onchocerca volvulus 0.0009 0.002 0.0071
Mycobacterium tuberculosis Probable hydrolase 0.0114 0.1348 0.1339
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0643 0.4139
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0172 0.0087
Echinococcus granulosus survival motor neuron protein 1 0.0269 0.3303 0.6285
Schistosoma mansoni lamin 0.0027 0.024 0.0457
Trypanosoma brucei unspecified product 0.0019 0.0145 0.0585
Schistosoma mansoni cpg binding protein 0.0036 0.0354 0.0674
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0714 0.136
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0374 0.0713
Brugia malayi TAR-binding protein 0.0127 0.1515 0.4587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1118 0.1108
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0374 0.0364
Onchocerca volvulus 0.0114 0.1348 0.4778
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1515 0.2886
Leishmania major hypothetical protein, conserved 0.0033 0.0326 0.1504
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0058 0.0643 0.4139
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.002 0.0017
Loa Loa (eye worm) hypothetical protein 0.0127 0.1505 0.4524
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.002 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Plasmodium vivax peptide deformylase, putative 0.0225 0.2754 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.002 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.1118 0.1108
Echinococcus granulosus endonuclease exonuclease phosphatase 0.022 0.2684 0.5103
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.1515 0.4587
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0374 0.0713
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0141
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0114 0.1348 0.2569
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0172 0.0087
Brugia malayi MAP kinase sur-1 0.0058 0.0643 0.1947
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0055 0.0596 0.1135
Loa Loa (eye worm) intermediate filament protein 0.0027 0.024 0.067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0114 0.1348 0.4082
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0084 0.0255
Brugia malayi beta-lactamase family protein 0.0114 0.1348 0.4082
Treponema pallidum polypeptide deformylase (def) 0.0225 0.2754 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0145 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.002 0.006
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1515 0.2886
Brugia malayi hypothetical protein 0.0127 0.1505 0.4557
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.002 0.0017
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0225 0.2754 0.2903
Schistosoma mansoni hypothetical protein 0.0033 0.0326 0.0621
Loa Loa (eye worm) hypothetical protein 0.0114 0.1348 0.4046
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0598 0.1809
Echinococcus granulosus lamin dm0 0.0027 0.024 0.0437
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.002 0.0009
Mycobacterium ulcerans peptide deformylase 0.0225 0.2754 0.831
Echinococcus multilocularis survival motor neuron protein 1 0.0269 0.3303 0.3296

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 2.59 uM Antagonist activity at human progesterone receptor in T47D cells after 24 hrs by alkaline phosphatase assay ChEMBL. 21916484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.