Detailed information for compound 1173992

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 679.224 | Formula: C39H35ClN2O5S
  • H donors: 2 H acceptors: 4 LogP: 8.3 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)COc1ccc(cc1)Cc1c(CCNS(=O)(=O)Cc2ccccc2)n(c2c1cc(Cl)cc2)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C39H35ClN2O5S/c40-32-18-21-36-35(25-32)34(24-28-16-19-33(20-17-28)47-26-38(43)44)37(22-23-41-48(45,46)27-29-10-4-1-5-11-29)42(36)39(30-12-6-2-7-13-30)31-14-8-3-9-15-31/h1-21,25,39,41H,22-24,26-27H2,(H,43,44)
  • InChiKey: RBERAMDXODUGQT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0504
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0057 0.012
Brugia malayi MH1 domain containing protein 0.0014 0.0007 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.0812
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0016 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0115
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.006 0.0127
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.0812
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0038 0.0072 0.0396
Brugia malayi MH2 domain containing protein 0.0026 0.0039 0.0279
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0031 0.1645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0035 0.0062 0.045
Loa Loa (eye worm) hypothetical protein 0.0148 0.0367 0.2644
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0107 0.0255 0.1838
Echinococcus granulosus caspase 8 0.0031 0.0052 0.0285
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0032 0.0404
Plasmodium falciparum metacaspase-like protein 0.0031 0.0052 0.2755
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0032 0.0404
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0016 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0319 0.0825 0.5946
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0018 0.0101
Echinococcus multilocularis muscleblind protein 0.0148 0.0367 0.0772
Schistosoma mansoni smad1 5 8 and 0.0026 0.0039 0.0214
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.013 0.0722
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0367 0.0772
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0147 0.1058
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0185 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.019 0.1372
Echinococcus granulosus cpg binding protein 0.0062 0.0134 0.0744
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0038 0.0072 0.0918
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0013 0.0027
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0504
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0024 0.0033 0.0012
Toxoplasma gondii ABC1 family protein 0.0038 0.007 0.0069
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0011 0.0022
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0504
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0032 0.0031
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0082 0.1051
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0062 0.045
Onchocerca volvulus 0.0016 0.0013 0.0093
Loa Loa (eye worm) transcription factor SMAD2 0.0382 0.0995 0.7172
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0029 0.0047 0.0045
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.013 0.0722
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.007 0.0504
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0054 0.0053
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0016 0.0015
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0013 0.0093
Onchocerca volvulus 0.0038 0.007 0.0504
Onchocerca volvulus 0.0176 0.044 0.3174
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Schistosoma mansoni cpg binding protein 0.0062 0.0134 0.0744
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0097 0.0699
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.0812
Brugia malayi hypothetical protein 0.0052 0.0109 0.0783
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0032 0.0031
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0231 0.0487
Brugia malayi Pre-SET motif family protein 0.0208 0.0527 0.3797
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.007 0.0069
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.019 0.1053
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0082 0.1051
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0049 0.0048
Echinococcus granulosus caspase 0.0031 0.0052 0.0285
Echinococcus granulosus Niemann Pick C1 protein 0.014 0.0344 0.1901
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0504
Echinococcus multilocularis protein dispatched 1 0.0048 0.0097 0.0205
Trichomonas vaginalis glutaminase, putative 0.0285 0.0735 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.007 0.0504
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0031 0.1645
Brugia malayi Muscleblind-like protein 0.0148 0.0367 0.2644
Schistosoma mansoni nuclear receptor 0.0016 0.0013 0.0072
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0031 0.0052 0.0109
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.007 0.0069
Echinococcus multilocularis GPCR, family 2 0.0033 0.0057 0.012
Brugia malayi nuclear receptor NHR-88 0.0035 0.0062 0.045
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.3736 1 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0062 0.0131
Toxoplasma gondii type I fatty acid synthase, putative 0.0021 0.0026 0.0025
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.006 0.0059
Leishmania major hypothetical protein, conserved 0.0081 0.0185 0.2391
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0062 0.0345
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0019 0.0021 0.002
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0062 0.0131
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0031 0.003
Brugia malayi steroid hormone receptor 0.0035 0.0062 0.045
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0372
Brugia malayi polk-prov protein 0.0012 0.0001 0.0005
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.016 0.1151
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.007 0.0897
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0099
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0132
Entamoeba histolytica hypothetical protein 0.0036 0.0065 0.1678
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.004 0.0505
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0097 0.0701
Echinococcus granulosus Smad4 0.0026 0.0039 0.0214
Schistosoma mansoni smad1 5 8 and 0.0026 0.0039 0.0214
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0032 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0286
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0013 0.0072
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0147 0.1058
Plasmodium vivax hypothetical protein, conserved 0.0038 0.007 0.3751
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.0812
Mycobacterium tuberculosis Conserved protein 0.0038 0.007 0.0069
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0031 0.0393
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0231 1
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0013 0.0072
Onchocerca volvulus 0.0035 0.0062 0.045
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Echinococcus multilocularis cpg binding protein 0.0062 0.0134 0.0283
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0185 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0066 0.0365
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0031 0.003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0011 0.0022
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0081 0.0586
Echinococcus granulosus geminin 0.0345 0.0896 0.4961
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0045 0.0089 0.0088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0065 0.0357
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0032 0.0054 0.0053
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Trypanosoma cruzi transcription factor btf3, putative 0.0079 0.018 0.232
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0045 0.0251
Loa Loa (eye worm) acyl carrier protein 0.0014 0.0006 0.0041
Brugia malayi CHE-14 protein 0.0042 0.0081 0.0586
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0248 0.1788
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0107 0.0256 0.1848
Entamoeba histolytica hypothetical protein 0.0036 0.0065 0.1678
Brugia malayi ImpB/MucB/SamB family protein 0.0038 0.0072 0.0516
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0039 0.0279
Echinococcus multilocularis Smad4 0.0026 0.0039 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0185 0.2391
Onchocerca volvulus 0.0528 0.1387 1
Onchocerca volvulus 0.0024 0.0032 0.023
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0031 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0504
Brugia malayi glutaminase DH11.1 0.0285 0.0735 0.5301
Schistosoma mansoni glutaminase 0.0285 0.0735 0.4069
Trypanosoma brucei unspecified product 0.0038 0.0072 0.0918
Schistosoma mansoni patched 1 0.0042 0.0081 0.045
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0039 0.0279
Loa Loa (eye worm) glutaminase 0.0285 0.0735 0.5301
Loa Loa (eye worm) beta-lactamase 0.0038 0.007 0.0504
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0038 0.0072 0.0151
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.002 0.0112
Onchocerca volvulus Cell death protein 3 homolog 0.0031 0.0052 0.0372
Loa Loa (eye worm) hypothetical protein 0.0051 0.0107 0.0769
Brugia malayi photoreceptor-specific nuclear receptor 0.0319 0.0825 0.5946
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.013 0.0129
Onchocerca volvulus 0.0059 0.0127 0.0917
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0052 0.0285
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0052 0.0109
Brugia malayi nuclear hormone receptor 0.0035 0.0062 0.045
Trichomonas vaginalis DNA polymerase eta, putative 0.0038 0.0072 0.0921
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Mycobacterium tuberculosis Conserved protein 0.0038 0.007 0.0069
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Schistosoma mansoni hypothetical protein 0.004 0.0077 0.0427
Mycobacterium tuberculosis Conserved hypothetical protein 0.0038 0.0072 0.007
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0031 0.003
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.003 0.0049 0.0354
Echinococcus granulosus transcription factor eb 0.0107 0.0256 0.1418
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0001 0.0004
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0013 0.0093
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.006 0.077
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.006 0.077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0035 0.0062 0.045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0132
Mycobacterium ulcerans lipase LipD 0.0038 0.007 0.0069
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0032 0.0031
Onchocerca volvulus 0.0038 0.007 0.0504
Echinococcus multilocularis expressed conserved protein 0.0092 0.0215 0.0453
Echinococcus granulosus muscleblind protein 0.0148 0.0367 0.2029
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0032 0.0043
Trypanosoma brucei metacaspase 5, putative 0.0031 0.0052 0.0659
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0013 0.0093
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0081 0.045
Onchocerca volvulus Bile acid receptor homolog 0.0035 0.0062 0.045
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0031 1
Onchocerca volvulus 0.0031 0.0052 0.0373
Brugia malayi beta-lactamase family protein 0.0038 0.007 0.0504
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0011 0.0059
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0017 0.0014 0.0013
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0185 0.2391
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.006 0.0127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Brugia malayi conserved hypotetical protein 0.0016 0.0013 0.0093
Brugia malayi Smad1 0.0026 0.0039 0.0279
Brugia malayi TAR-binding protein 0.0066 0.0147 0.1058
Trypanosoma brucei transcription factor BTF3, putative 0.0079 0.018 0.232
Mycobacterium leprae Probable lipase LipE 0.0038 0.007 0.0048
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0032 0.0054 0.0053
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0038 0.0072 0.0921
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Trypanosoma brucei metacaspase MCA3 0.0031 0.0052 0.0659
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0773 1
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.0599 0.1261
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0527 0.3797
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.007 0.0899
Echinococcus granulosus transcription factor btf3 0.0079 0.018 0.0996
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0029 0.0047 0.0045
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0067 1
Entamoeba histolytica hypothetical protein 0.0079 0.018 0.7444
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0013 0.0072
Loa Loa (eye worm) hypothetical protein 0.0081 0.0185 0.1337
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0125 0.0904
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0062 0.0345
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.006 0.0127
Loa Loa (eye worm) nuclear receptor NHR-67 0.0016 0.0013 0.0093
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0081 0.1054
Onchocerca volvulus 0.0058 0.0125 0.0904
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0013 0.0093
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.1807 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0349 0.4515
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0139 0.1796
Toxoplasma gondii type I fatty acid synthase, putative 0.0033 0.0057 0.0056
Brugia malayi MH1 domain containing protein 0.0014 0.0007 0.0053
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0025 0.0036 0.0014
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0032 0.0054 0.0032
Brugia malayi nuclear receptor RXR 0.0018 0.0018 0.0132
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Brugia malayi isocitrate dehydrogenase 0.0034 0.006 0.0434
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0132
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0065 0.0357
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0035 0.0062 0.0061
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0185 0.0185
Echinococcus granulosus nuclear receptor nhr 48 0.0016 0.0013 0.0072
Brugia malayi MH1 domain containing protein 0.0026 0.0039 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0062 0.0345
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0035 0.0062 0.045
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0062 0.0345
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.086
Echinococcus multilocularis transcription factor eb 0.0107 0.0256 0.054
Echinococcus multilocularis smad 0.0026 0.0039 0.0081
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.023
Onchocerca volvulus 0.0236 0.0603 0.4349
Brugia malayi nuclear hormone receptor 0.0016 0.0013 0.0093
Loa Loa (eye worm) hypothetical protein 0.0033 0.0057 0.0412
Schistosoma mansoni terminal deoxycytidyl transferase 0.0038 0.0072 0.0396
Schistosoma mansoni inositol monophosphatase 0.0037 0.0067 0.0372
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.018 0.2403
Brugia malayi hypothetical protein 0.0018 0.0018 0.0132
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0372
Trypanosoma brucei Metacaspase-4 0.0031 0.0052 0.0659
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0057 0.0412
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0016 0.0013 0.0072
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.006 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0035 0.0062 0.045
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0057 0.0412
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0018 0.0101
Echinococcus granulosus dna polymerase eta 0.0064 0.0139 0.0772
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0125 0.0304 0.1682
Mycobacterium ulcerans Type I modular polyketide synthase 0.003 0.0049 0.0048
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.013 0.013
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0016 0.0015
Schistosoma mansoni survival motor neuron protein 0.0048 0.0097 0.0538
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.3736 1 1
Mycobacterium ulcerans beta-lactamase 0.0038 0.007 0.0069
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.013 0.0722
Mycobacterium leprae conserved hypothetical protein 0.0038 0.007 0.0048
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0032 0.023
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.006 0.077
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0069 0.0068
Loa Loa (eye worm) nuclear factor I 0.0014 0.0007 0.0053
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0035 0.0062 0.045
Schistosoma mansoni hypothetical protein 0.0033 0.0057 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Onchocerca volvulus 0.0035 0.0062 0.045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0097 0.0537
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0057 0.0316
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0067 0.086
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.086
Echinococcus multilocularis caspase 8 0.0031 0.0052 0.0109
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Schistosoma mansoni hypothetical protein 0.0033 0.0057 0.0316
Leishmania major basic transcription factor 3a, putative 0.0079 0.018 0.232
Leishmania major metacaspase, putative 0.0031 0.0052 0.0659
Entamoeba histolytica deoxycytidyl transferase, putative 0.0038 0.0072 0.2027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0035 0.0062 0.045
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0062 0.0345
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0016 0.0827
Mycobacterium tuberculosis Probable thioesterase TesA 0.0025 0.0036 0.0034
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0011 0.0059
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0072 0.0071
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.013 0.1681
Trypanosoma cruzi metacaspase, putative 0.0031 0.0052 0.0659
Schistosoma mansoni hypothetical protein 0.004 0.0077 0.0427
Echinococcus granulosus expressed conserved protein 0.0092 0.0215 0.119
Loa Loa (eye worm) hypothetical protein 0.0042 0.0081 0.0586
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0031 0.5
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0081 0.045
Loa Loa (eye worm) hypothetical protein 0.0107 0.0255 0.1838
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0647
Echinococcus multilocularis transcription factor btf3 0.0079 0.018 0.0379
Mycobacterium ulcerans hypothetical protein 0.0038 0.007 0.0069
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0032 0.0031
Brugia malayi Cell death protein 3 precursor 0.0031 0.0052 0.0372
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0016 0.0827
Brugia malayi Pax transcription factor protein 2 0.0528 0.1387 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0032 0.0404
Loa Loa (eye worm) steroid hormone receptor 0.0035 0.0062 0.045
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0067 0.0372
Onchocerca volvulus 0.0048 0.0097 0.0701
Schistosoma mansoni cpg binding protein 0.0058 0.0125 0.0694
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0147 0.0309
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0035 0.0062 0.045
Brugia malayi RNA binding protein 0.0066 0.0147 0.1058
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.007 0.0899
Brugia malayi ecdysteroid receptor 0.0035 0.0062 0.045
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.006 0.3219
Echinococcus granulosus GPCR family 2 0.0033 0.0057 0.0316
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0032 0.0043
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0062 0.0131
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.019 0.0401
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0032 0.0054 0.0032
Onchocerca volvulus 0.0038 0.007 0.0504
Loa Loa (eye worm) MH2 domain-containing protein 0.0382 0.0995 0.7172
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Toxoplasma gondii hypothetical protein 0.0048 0.0099 0.0098
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0031 0.0052 0.0285
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0035 0.0062 0.045
Echinococcus multilocularis neuropeptide receptor A26 0.0459 0.12 0.2529
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0097 0.0537
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0139 0.1005
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.003 0.0049 0.0027
Schistosoma mansoni hypothetical protein 0.0036 0.0066 0.0365
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0185 0.2391
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0032 0.001
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0066 0.0139
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0032 0.0054 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0016 0.0013 0.0027
Trypanosoma cruzi metacaspase 5, putative 0.0031 0.0052 0.0659
Schistosoma mansoni hypothetical protein 0.0048 0.0097 0.0538
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0062 0.0345
Brugia malayi MH2 domain containing protein 0.0382 0.0995 0.7172
Mycobacterium ulcerans hypothetical protein 0.0024 0.0032 0.0031
Mycobacterium ulcerans polyketide synthase Pks9 0.002 0.0022 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.007 0.0504
Mycobacterium ulcerans polyketide synthase 0.0032 0.0054 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.007 0.0897
Echinococcus multilocularis nuclear receptor nhr 48 0.0016 0.0013 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.004 0.0505
Leishmania major DNA polymerase eta, putative 0.0037 0.0069 0.0878
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0038 0.0072 0.0396
Toxoplasma gondii pantoate-beta-alanine ligase 0.3736 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0147 0.1058
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0035 0.0062 0.045
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0013 0.0072
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0069 0.0878
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.002 0.0022 0.0021
Trypanosoma brucei metacaspase MCA2 0.0031 0.0052 0.0659
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0035 0.0062 0.0345
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0057 0.0316
Echinococcus granulosus dnaJ subfamily B 0.0425 0.1111 0.6146
Trypanosoma brucei unspecified product 0.0026 0.004 0.0505
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0013 0.0072
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0615 0.0614
Brugia malayi ecdysone receptor 0.0016 0.0013 0.0093
Onchocerca volvulus Fatty acid synthase homolog 0.0054 0.0114 0.0819
Schistosoma mansoni nuclear receptor 0.0016 0.0013 0.0072
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.006 0.077
Brugia malayi beta-lactamase family protein 0.0038 0.007 0.0504
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0039 0.0214
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0022 0.0026 0.0025
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0072 0.0918
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Schistosoma mansoni hypothetical protein 0.0345 0.0896 0.4961
Mycobacterium ulcerans polyketide synthase Pks13 0.0045 0.0089 0.0088
Mycobacterium leprae Polyketide synthase Pks13 0.0045 0.0089 0.0067
Trypanosoma cruzi transcription factor btf3, putative 0.0079 0.018 0.232
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0024 0.0033 0.0033
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0031 0.003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0032 0.0031
Mycobacterium leprae Probable polyketide synthase Pks1 0.0032 0.0054 0.0032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.004 0.0449
Entamoeba histolytica hypothetical protein 0.0036 0.0065 0.1678
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.007 0.0387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0035 0.0062 0.045
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.007 0.0069
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0018 0.0132
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0013 0.0093
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0016 0.0013 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0286
Loa Loa (eye worm) hypothetical protein 0.0031 0.0052 0.0373
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0035 0.0062 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Echinococcus granulosus tar DNA binding protein 0.0066 0.0147 0.0812
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.013 0.0275
Schistosoma mansoni hypothetical protein 0.0345 0.0896 0.4961
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.006 0.0127
Loa Loa (eye worm) fatty acid synthase 0.003 0.0048 0.0347
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0032 0.0054 0.0053
Echinococcus granulosus microtubule associated protein 2 0.0685 0.1807 1
Schistosoma mansoni smad 0.0026 0.0039 0.0214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0097 0.0537
Echinococcus multilocularis dna polymerase eta 0.0064 0.0139 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.004 0.0505
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0349 0.4515
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0067 0.086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.006 0.0127
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.013 0.013
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0011 0.0059
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.007 0.0899
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0031 0.0052 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Mycobacterium ulcerans thioesterase TesA 0.0025 0.0036 0.0035
Echinococcus granulosus dna polymerase kappa 0.0038 0.0072 0.0396
Mycobacterium tuberculosis Conserved protein 0.0038 0.007 0.0069
Brugia malayi CXXC zinc finger family protein 0.0058 0.0125 0.0904
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0067 0.086
Brugia malayi hypothetical protein 0.0018 0.0018 0.0132
Trypanosoma cruzi metacaspase, putative 0.0031 0.0052 0.0659
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0018 0.0132
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.1807 0.3807
Brugia malayi hypothetical protein 0.0016 0.0013 0.0093
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0147 0.0812
Trypanosoma cruzi metacaspase, putative 0.0031 0.0052 0.0659
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.006 0.3219
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0018 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0057 0.0056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0013 0.0012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0248 0.1788
Schistosoma mansoni hypothetical protein 0.0033 0.0057 0.0316
Echinococcus granulosus thyroid hormone receptor alpha 0.0016 0.0013 0.0072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0035 0.0062 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0051 0.0106 0.0767
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0115
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Loa Loa (eye worm) histone methyltransferase 0.0019 0.002 0.0145
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.007 0.0069
Echinococcus multilocularis thyroid hormone receptor alpha 0.0035 0.0062 0.0131
Trypanosoma cruzi metacaspase 5, putative 0.0031 0.0052 0.0659
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0115
Plasmodium falciparum metacaspase 1 0.0031 0.0052 0.2755
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.007 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.002 0.0042
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0067 0.0141
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0647
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0062 0.0345
Schistosoma mansoni hypothetical protein 0.0033 0.0057 0.0316
Plasmodium vivax basic transcription factor 3b, putative 0.0079 0.018 0.9704
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0031 0.0393
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0773 1
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.019 0.1053
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0349 0.4515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0062 0.0345
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.007 0.0387
Entamoeba histolytica hypothetical protein 0.0036 0.0065 0.1678
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0082 0.1051
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.0599 0.3313
Loa Loa (eye worm) hypothetical protein 0.0176 0.044 0.3174
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0016 0.0013 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0097 0.0204
Echinococcus granulosus Nuclear hormone receptor HR96 0.0016 0.0013 0.0072
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0081 0.0171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0052 0.0109
Schistosoma mansoni nuclear hormone receptor 0.0035 0.0062 0.0345
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Echinococcus granulosus smad 0.0026 0.0039 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0032 0.023
Schistosoma mansoni thyroid hormone receptor 0.0035 0.0062 0.0345
Leishmania major hypothetical protein, conserved 0.0038 0.007 0.0897
Schistosoma mansoni hypothetical protein 0.004 0.0077 0.0427
Trypanosoma cruzi metacaspase, putative 0.0031 0.0052 0.0659
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0049 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0052 0.2755
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0035 0.0062 0.045
Mycobacterium ulcerans thioesterase 0.0025 0.0036 0.0035
Loa Loa (eye worm) DR-78 0.0016 0.0013 0.0093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0035 0.0062 0.0345
Brugia malayi hypothetical protein 0.0081 0.0185 0.1337
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0018 0.0101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0062 0.045
Brugia malayi MH1 domain containing protein 0.0026 0.0039 0.0279
Loa Loa (eye worm) glutaminase 2 0.0285 0.0735 0.5301
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0032 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0039 0.0214
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0082 0.1051
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0067 0.0066
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0052 0.0051
Onchocerca volvulus 0.0016 0.0013 0.0093
Entamoeba histolytica transcription factor BTF3, putative 0.0079 0.018 0.7444
Brugia malayi beta-lactamase 0.0038 0.007 0.0504
Plasmodium falciparum basic transcription factor 3b, putative 0.0079 0.018 0.9704
Brugia malayi Pre-SET motif family protein 0.0031 0.0052 0.0373
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0013 0.0093
Echinococcus multilocularis neuropeptide s receptor 0.0459 0.12 0.2529
Brugia malayi Steroid receptor seven-up type 2 0.0035 0.0062 0.045
Schistosoma mansoni Smad4 0.0026 0.0039 0.0214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0035 0.0062 0.045
Schistosoma mansoni RAR-like nuclear receptor 0.0035 0.0062 0.0345
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0248 0.1788
Schistosoma mansoni zinc finger protein 0.0016 0.0013 0.0072
Trypanosoma brucei metacaspase 0.0031 0.0052 0.0659
Trypanosoma cruzi DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.007 0.0069
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.007 0.0897
Giardia lamblia DINP protein human, muc B family 0.0038 0.0072 1
Loa Loa (eye worm) RNA binding protein 0.0066 0.0147 0.1058
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0107 0.1371
Leishmania major DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.006 0.0434
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0039 0.0081
Echinococcus multilocularis Niemann Pick C1 protein 0.014 0.0344 0.0724
Loa Loa (eye worm) hypothetical protein 0.0148 0.0367 0.2644
Loa Loa (eye worm) hypothetical protein 0.0082 0.019 0.1372
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0031 0.003
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1779 0.4747 1
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0062 0.045
Loa Loa (eye worm) hypothetical protein 0.0098 0.0231 0.1666
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0032 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0062 0.045
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.086
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0067 0.1805
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0097 0.0537
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0057 0.0035
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0038 0.0072 0.007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0007 0.0053
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0045 0.0089 0.0088
Echinococcus multilocularis caspase 2 0.0031 0.0052 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0062 0.0131
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.007 0.0899
Trichomonas vaginalis esterase, putative 0.0038 0.007 0.0899
Brugia malayi hypothetical protein 0.0036 0.0065 0.0466
Echinococcus multilocularis dnaJ subfamily B 0.0425 0.1111 0.234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0013 0.0093
Onchocerca volvulus 0.0082 0.019 0.1372
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.018 0.2403
Schistosoma mansoni hypothetical protein 0.0071 0.016 0.0884
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.007 0.0069
Schistosoma mansoni DNA polymerase eta 0.0064 0.0139 0.0772
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0039 0.0081
Loa Loa (eye worm) Smad1 0.0026 0.0039 0.0279
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0024 0.0033 0.0033
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.007 0.0147
Loa Loa (eye worm) hypothetical protein 0.0235 0.0599 0.4316
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0097 0.0537
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0062 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0035 0.0062 0.045
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0603 0.8193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0062 0.0345
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0185 1
Schistosoma mansoni hypothetical protein 0.0425 0.1111 0.6146
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.003 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0035 0.0062 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0132
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.013 0.013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0052 0.0286
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.006 0.0333
Schistosoma mansoni cpg binding protein 0.0062 0.0134 0.0744
Trypanosoma brucei unspecified product 0.0026 0.004 0.0505
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.018 0.2403
Brugia malayi nuclear receptor NHR-67 0.0016 0.0013 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0097 0.0204
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0062 0.0345
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.003 0.0049 0.0048
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0057 0.0121 0.0873
Brugia malayi hypothetical protein 0.0235 0.0599 0.4316
Schistosoma mansoni transcription factor btf3 0.0079 0.018 0.0996
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.0773 1
Brugia malayi nuclear receptor NHR-88 0.0016 0.0013 0.0093
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0235 0.1301
Echinococcus multilocularis geminin 0.0345 0.0896 0.1888
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.013 0.013
Schistosoma mansoni coup transcription factor 0.0035 0.0062 0.0345
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.007 0.0899
Mycobacterium ulcerans DNA polymerase IV 0.0038 0.0072 0.0071
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0038 0.0072 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0647
Loa Loa (eye worm) hypothetical protein 0.0071 0.016 0.1151
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.007 0.0069
Mycobacterium ulcerans polyketide synthase 0.003 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0104 0.0248 0.1788
Loa Loa (eye worm) ICD-1 protein 0.0079 0.018 0.1297
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.002 0.0141
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0067 0.086
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0231 0.1278
Schistosoma mansoni inositol monophosphatase 0.0037 0.0067 0.0372
Onchocerca volvulus Protein ultraspiracle homolog 0.0035 0.0062 0.045
Brugia malayi nuclear receptor RXR 0.0016 0.0013 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0035 0.0062 0.045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0035 0.0062 0.0345
Brugia malayi Inositol-1 0.0037 0.0067 0.0484
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.007 0.0069
Mycobacterium ulcerans hypothetical protein 0.0158 0.0392 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0647
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0016 0.0013 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0139 0.1796
Loa Loa (eye worm) hypothetical protein 0.0012 0.0001 0.0005
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0031 0.0052 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0268 0.0268
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0031 0.0009
Echinococcus granulosus neuropeptide receptor A26 0.0459 0.12 0.6644
Leishmania major DNA polymerase eta, putative 0.0064 0.0139 0.1796
Toxoplasma gondii NAC domain-containing protein 0.0079 0.018 0.0179
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0018 0.0132
Schistosoma mansoni caspase-7 (C14 family) 0.0031 0.0052 0.0285
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0057 0.0412
Brugia malayi hypothetical protein 0.0016 0.0013 0.0093
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0062 0.0131
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0062 0.0345
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.007 0.0387
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0115
Schistosoma mansoni hypothetical protein 0.004 0.0077 0.0427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0013 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0062 0.045
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.006 0.077
Loa Loa (eye worm) inositol-1 0.0037 0.0067 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0647
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0024 0.0034 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0035 0.0062 0.045
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0072 0.0918
Loa Loa (eye worm) hypothetical protein 0.0018 0.0016 0.0115
Plasmodium vivax metacaspase 1, putative 0.0031 0.0052 0.2755
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0013 0.0093
Brugia malayi Isocitrate dehydrogenase 0.0034 0.006 0.0434
Schistosoma mansoni caspase-3 (C14 family) 0.0031 0.0052 0.0285
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0065 0.0136
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.006 0.0333
Schistosoma mansoni smad1 5 8 and 0.0026 0.0039 0.0214
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0062 0.0131
Schistosoma mansoni retinoic acid receptor RXR 0.0035 0.0062 0.0345
Loa Loa (eye worm) pax transcription factor protein 2 0.0528 0.1387 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0052 0.0647
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0067 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0097 0.0699
Schistosoma mansoni hypothetical protein 0.0036 0.0065 0.0357
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.003 0.0049 0.0048
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0031 0.0052 0.0051
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0035 0.0062 0.045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0035 0.0062 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Schistosoma mansoni steroid hormone receptor ad4bp 0.0035 0.0062 0.0345
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0031 0.0052 0.0647
Echinococcus granulosus neuropeptide s receptor 0.0459 0.12 0.6644
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0052 0.0286
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0072 0.0918
Echinococcus granulosus caspase 2 0.0031 0.0052 0.0285
Echinococcus multilocularis caspase 0.0031 0.0052 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0013 0.0012
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.003 0.0049 0.0027
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0013 0.0072
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0057 0.012
Leishmania major mitochondrial DNA polymerase beta 0.03 0.0773 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0032 0.023
Echinococcus multilocularis dna polymerase kappa 0.0038 0.0072 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918
Loa Loa (eye worm) nuclear hormone receptor 0.0016 0.0013 0.0093
Echinococcus multilocularis protein patched 0.0042 0.0081 0.0171
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.045
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0032 0.0031
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0016 0.0013 0.0027
Brugia malayi MH2 domain containing protein 0.0026 0.0039 0.0279
Mycobacterium ulcerans glutaminase 0.0285 0.0735 0.0735
Brugia malayi hypothetical protein 0.0176 0.044 0.3174
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0031 0.0052 0.0372
Loa Loa (eye worm) hypothetical protein 0.0064 0.0139 0.1005
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0013 0.0093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0392 0.0391
Brugia malayi tailless protein 0.0016 0.0013 0.0093
Brugia malayi beta-NAC-like protein 0.0079 0.018 0.1297
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0062 0.0131
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0039 0.0214
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0013 0.0012
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0231 0.1666
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0052 0.0286
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.006 0.0059
Plasmodium vivax SET domain protein, putative 0.0031 0.0052 0.2763
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0035 0.0062 0.045
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0072 0.0918

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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