Detailed information for compound 1176711

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1058.18 | Formula: C56H67N9O12
  • H donors: 8 H acceptors: 8 LogP: 3.15 Rotable bonds: 29
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(COCC(=O)NCCOc1cccc(c1)NC(=O)N[C@@H]1N=C(c2ccccc2)c2c(N(C1=O)C)cccc2)NCCCCCCNC(=O)COCC(=O)N[C@H]1CC[C@@]2([C@@]34[C@H]1Oc1c4c(C[C@H]2N(CC3)C)cc(c1)O)O
  • InChi: 1S/C56H67N9O12/c1-64-25-21-55-49-36-27-38(66)30-43(49)77-51(55)41(19-20-56(55,73)44(64)28-36)61-48(70)34-75-32-46(68)58-23-11-4-3-10-22-57-45(67)31-74-33-47(69)59-24-26-76-39-16-12-15-37(29-39)60-54(72)63-52-53(71)65(2)42-18-9-8-17-40(42)50(62-52)35-13-6-5-7-14-35/h5-9,12-18,27,29-30,41,44,51-52,66,73H,3-4,10-11,19-26,28,31-34H2,1-2H3,(H,57,67)(H,58,68)(H,59,69)(H,61,70)(H2,60,63,72)/t41-,44+,51-,52-,55-,56+/m0/s1
  • InChiKey: AWJDNWMDTDIGNU-NGEQUAPQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholecystokinin B receptor Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0022 0.0004 0.3558
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0013 0.0093
Loa Loa (eye worm) hypothetical protein 0.0474 0.032 0.0317
Loa Loa (eye worm) hypothetical protein 0.0354 0.0236 0.0233
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0022 0.0151
Toxoplasma gondii ImpB/MucB/SamB family protein 0.005 0.0024 0.2784
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0115 0.0069 0.1144
Echinococcus multilocularis lamin 0.0025 0.0006 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0013 0.0023
Loa Loa (eye worm) beta-lactamase 0.0138 0.0086 0.0083
Mycobacterium leprae conserved hypothetical protein 0.0138 0.0086 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0004 0.0008
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0032 0.0012 0.0914
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0019 0.0033
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0003 0.0355
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0034 0.0174
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.014 0.0087 0.0152
Brugia malayi hypothetical protein 0.0163 0.0103 0.0103
Brugia malayi beta-lactamase family protein 0.0138 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0022 0.0022
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0034 0.0174
Brugia malayi beta-lactamase 0.0138 0.0086 0.0086
Schistosoma mansoni lamin 0.0025 0.0006 0.0045
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0431 0.029 0.0287
Echinococcus multilocularis tumor protein p63 0.0322 0.0214 0.0376
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0047 0.0022 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0693 0.0473 0.0473
Leishmania major DNA polymerase kappa, putative 0.002 0.0003 0.0005
Brugia malayi ecdysone receptor 0.0022 0.0004 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0006 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0464 0.0314 0.2187
Echinococcus granulosus choline O acetyltransferase 0.1764 0.1222 0.2145
Schistosoma mansoni hypothetical protein 0.0219 0.0142 0.0992
Echinococcus multilocularis thioredoxin glutathione reductase 0.0045 0.0021 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0084 0.0587
Trichomonas vaginalis DNA polymerase eta, putative 0.0065 0.0034 0.1489
Brugia malayi tailless protein 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0083
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0022 0.0004 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0006 0.0011
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0047 0.0022 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0138 0.0086 0.0597
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0431 0.029 0.029
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0034 0.337
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0103 0.0061 0.1011
Brugia malayi Calcitonin receptor-like protein seb-1 0.0693 0.0473 0.0473
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.1764 0.1222 0.6223
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0004 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0182 0.7923
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0084 0.0587
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0056 0.0028 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.1764 0.1222 0.2145
Leishmania major hypothetical protein, conserved 0.0138 0.0086 0.015
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0006 0.0011
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0073 0.004 0.4378
Loa Loa (eye worm) DR-78 0.0022 0.0004 0.0001
Echinococcus multilocularis geminin 0.0377 0.0253 0.0444
Brugia malayi hypothetical protein 0.0078 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0077 0.0043 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0047 0.0022 0.0019
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.0156 0.0153
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Schistosoma mansoni DNA polymerase eta 0.0094 0.0055 0.0383
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0122 0.5331
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0003 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0013 0.0093
Onchocerca volvulus 0.0047 0.0022 0.0144
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0182 0.7923
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0103 0.0061 0.7009
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0003 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0015
Schistosoma mansoni hypothetical protein 0.0474 0.032 0.2232
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0003 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0047 0.0022 0.0019
Schistosoma mansoni inositol monophosphatase 0.0032 0.0012 0.0082
Echinococcus multilocularis cpg binding protein 0.0032 0.0012 0.002
Brugia malayi Latrophilin receptor protein 2 0.0219 0.0142 0.0142
Schistosoma mansoni lamin 0.0025 0.0006 0.0045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0028 0.2795
Entamoeba histolytica hypothetical protein 0.014 0.0087 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0013 0.1557
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0086 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0044 0.0077
Mycobacterium tuberculosis Probable dehydrogenase 0.0103 0.0061 0.1011
Trypanosoma cruzi hypothetical protein, conserved 0.1764 0.1222 0.2145
Schistosoma mansoni tar DNA-binding protein 0.0464 0.0314 0.2187
Echinococcus granulosus geminin 0.0377 0.0253 0.0444
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0003 0.0005
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0022 0.0004 0.0411
Trypanosoma brucei hypothetical protein, conserved 0.0138 0.0086 0.0436
Trichomonas vaginalis set domain proteins, putative 0.0271 0.0179 0.7782
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.009 0.0458
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0056 0.0028 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Echinococcus granulosus survival motor neuron protein 1 0.0471 0.0318 0.0558
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0003 0.0005
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0077 0.0043 0.0043
Echinococcus granulosus FTZ F1 alpha 0.0047 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.2825 0.1963 0.3447
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0044 0.5118
Loa Loa (eye worm) hypothetical protein 0.1764 0.1222 0.1219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0073 0.004 0.4438
Trichomonas vaginalis penicillin-binding protein, putative 0.0138 0.0086 0.373
Brugia malayi hypothetical protein 0.0471 0.0318 0.0318
Schistosoma mansoni nuclear receptor 0.0022 0.0004 0.0031
Mycobacterium ulcerans hypothetical protein 0.0138 0.0086 0.8443
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0022 0.0004 1
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0034 0.0034
Brugia malayi Choline O-acetyltransferase 0.1764 0.1222 0.1222
Plasmodium vivax thioredoxin reductase, putative 0.0045 0.0021 0.2417
Schistosoma mansoni nuclear receptor 0.0022 0.0004 0.0031
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0012 0.051
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.2825 0.1963 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0012 0.006
Echinococcus multilocularis neuropeptide receptor A26 0.0871 0.0598 0.105
Loa Loa (eye worm) hypothetical protein 0.0471 0.0318 0.0315
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0083
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0182 0.7923
Leishmania major DNA polymerase kappa, putative 0.0065 0.0034 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0344 0.0229 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0219 0.0142 0.025
Leishmania major phosphopantetheinyl transferase-like protein 0.0022 0.0004 0.0007
Mycobacterium tuberculosis Probable reductase 0.0103 0.0061 0.1011
Mycobacterium tuberculosis Conserved protein 0.0138 0.0086 0.1413
Brugia malayi hypothetical protein 0.0022 0.0004 0.0004
Loa Loa (eye worm) RNA binding protein 0.0464 0.0314 0.0311
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0047 0.0022 0.0038
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0022 0.0004 0.0069
Echinococcus multilocularis microtubule associated protein 2 0.2067 0.1433 0.2517
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0103 0.0061 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0094 0.0055 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0464 0.0314 0.2187
Onchocerca volvulus 0.0077 0.0043 0.0316
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.003 0.3541
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0004 0.0004
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.009 0.0158
Loa Loa (eye worm) glutathione reductase 0.0045 0.0021 0.0018
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0032 0.0012 0.1368
Brugia malayi TAR-binding protein 0.0464 0.0314 0.0314
Echinococcus granulosus neuropeptide receptor A26 0.0871 0.0598 0.105
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0004 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0182 0.7923
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.2825 0.1963 0.3447
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0103 0.0061 0.1011
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0354 0.0236 0.0236
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0073 0.004 0.0205
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0202 0.0355
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0032 0.0012 0.1155
Echinococcus granulosus beta LACTamase domain containing family member 0.0138 0.0086 0.015
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0004 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0138 0.0086 0.0086
Schistosoma mansoni cpg binding protein 0.0032 0.0012 0.0081
Schistosoma mansoni intermediate filament proteins 0.0025 0.0006 0.0045
Brugia malayi hypothetical protein 0.0051 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0003 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.1764 0.1222 0.6223
Echinococcus multilocularis dna polymerase kappa 0.0065 0.0034 0.006
Echinococcus multilocularis survival motor neuron protein 1 0.0471 0.0318 0.0558
Onchocerca volvulus 0.0031 0.001 0.0049
Trichomonas vaginalis esterase, putative 0.0138 0.0086 0.373
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.0202 0.0355
Brugia malayi nuclear receptor NHR-67 0.0022 0.0004 0.0004
Leishmania major DNA polymerase eta, putative 0.005 0.0024 0.0042
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0022 0.0038
Toxoplasma gondii proteasome subunit beta type, putative 0.0073 0.004 0.4709
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.009 0.0158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0013 0.001
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.8167 0.5695 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0004 0.0001
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0003 0.0015
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Mycobacterium tuberculosis Probable lipase LipD 0.0138 0.0086 0.1413
Loa Loa (eye worm) MH2 domain-containing protein 0.02 0.0129 0.0126
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0065 0.0034 0.006
Onchocerca volvulus 0.1764 0.1222 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Echinococcus multilocularis inositol monophosphatase 1 0.0032 0.0012 0.0021
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1764 0.1222 0.2145
Schistosoma mansoni microtubule-associated protein tau 0.2067 0.1433 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0096 0.0056 0.0056
Schistosoma mansoni inositol monophosphatase 0.0032 0.0012 0.0082
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0115 0.0069 0.1144
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1764 0.1222 0.6223
Brugia malayi Pre-SET motif family protein 0.0035 0.0013 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.0202 0.1031
Schistosoma mansoni tar DNA-binding protein 0.0464 0.0314 0.2187
Trypanosoma cruzi hypothetical protein, conserved 0.1764 0.1222 0.2145
Brugia malayi latrophilin 2 splice variant baaae 0.0474 0.032 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.002 0.0103
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0012 0.0021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0693 0.0473 0.047
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0138 0.0086 0.0083
Echinococcus multilocularis dna polymerase eta 0.0094 0.0055 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0122 0.5331
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0004 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0047 0.0022 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0022 0.0038
Mycobacterium ulcerans proteasome PrcB 0.0073 0.004 0.3976
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Schistosoma mansoni cellular tumor antigen P53 0.0047 0.0022 0.0153
Onchocerca volvulus 0.0163 0.0103 0.0809
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0136 0.0084 0.0084
Toxoplasma gondii ABC1 family protein 0.0138 0.0086 1
Toxoplasma gondii thioredoxin reductase 0.0045 0.0021 0.2417
Mycobacterium tuberculosis Probable oxidoreductase 0.0115 0.0069 0.1144
Onchocerca volvulus 0.0025 0.0006 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1764 0.1222 0.2145
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0047 0.0022 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.1764 0.1222 0.2145
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0077 0.0043 0.0299
Trypanosoma cruzi trypanothione reductase, putative 0.0045 0.0021 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0084 0.0148
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0219 0.0142 0.0139
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0056 0.0028 0.005
Schistosoma mansoni RAR-like nuclear receptor 0.0047 0.0022 0.0151
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0084 0.0148
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0464 0.0314 0.0311
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0019 0.0097
Plasmodium vivax SET domain protein, putative 0.0035 0.0013 0.1557
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.014 0.0087 0.0152
Onchocerca volvulus 0.1764 0.1222 1
Brugia malayi steroid hormone receptor 0.0047 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0004 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0056 0.0028 0.0468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0136 0.0084 0.0148
Echinococcus multilocularis musashi 0.0025 0.0006 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0034 0.006
Brugia malayi photoreceptor-specific nuclear receptor 0.0047 0.0022 0.0022
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.8167 0.5695 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0047 0.0022 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0004 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.002 0.0103
Brugia malayi Pre-SET motif family protein 0.0238 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0022 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0022 0.0004 0.0487
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0073 0.004 0.1756
Schistosoma mansoni retinoic acid receptor RXR 0.0047 0.0022 0.0151
Mycobacterium tuberculosis Probable lipase LipE 0.0138 0.0086 0.1413
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0047 0.0022 0.0151
Echinococcus granulosus tumor protein p63 0.0322 0.0214 0.0376
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0115 0.0069 0.7999
Brugia malayi Thioredoxin reductase 0.0045 0.0021 0.0021
Schistosoma mansoni zinc finger protein 0.0022 0.0004 0.0031
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1764 0.1222 0.2145
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0047 0.0022 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.002 0.0103
Loa Loa (eye worm) hypothetical protein 0.0693 0.0473 0.047
Echinococcus granulosus thioredoxin glutathione reductase 0.0045 0.0021 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0028 0.2795
Brugia malayi glutathione reductase 0.0045 0.0021 0.0021
Schistosoma mansoni steroid hormone receptor ad4bp 0.0047 0.0022 0.0151
Echinococcus granulosus cpg binding protein 0.0032 0.0012 0.002
Brugia malayi nuclear receptor NHR-88 0.0047 0.0022 0.0022
Plasmodium vivax proteasome subunit beta type-5, putative 0.0073 0.004 0.4709
Onchocerca volvulus 0.0138 0.0086 0.0667
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0047 0.0022 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Brugia malayi intermediate filament protein 0.0025 0.0006 0.0006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0012 0.0021
Onchocerca volvulus 0.0035 0.0013 0.0073
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0083
Brugia malayi ecdysteroid receptor 0.0047 0.0022 0.0022
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.2825 0.1963 0.3447
Schistosoma mansoni hypothetical protein 0.0219 0.0142 0.0992
Schistosoma mansoni hypothetical protein 0.0377 0.0253 0.1763
Trypanosoma brucei DNA polymerase IV, putative 0.0065 0.0034 0.0174
Loa Loa (eye worm) transcription factor SMAD2 0.02 0.0129 0.0126
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0138 0.0086 0.8443
Brugia malayi hypothetical protein 0.0025 0.0006 0.0006
Trypanosoma brucei DNA polymerase eta, putative 0.0094 0.0055 0.028
Leishmania major carnitine/choline acetyltransferase, putative 0.1764 0.1222 0.2145
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0047 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Brugia malayi nuclear receptor RXR 0.0022 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Entamoeba histolytica hypothetical protein 0.014 0.0087 1
Brugia malayi Choline O-acetyltransferase 0.1764 0.1222 0.1222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0047 0.0022 0.0019
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.004 0.0071
Schistosoma mansoni transcription factor LCR-F1 0.014 0.0087 0.0605
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0006 0.0003
Trypanosoma brucei trypanothione reductase 0.0045 0.0021 0.0105
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0138 0.0086 0.1413
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0073 0.004 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0004 0.0008
Echinococcus multilocularis L aminoadipate semialdehyde 0.0077 0.0043 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0013 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0138 0.0086 0.015
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.8167 0.5695 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0094 0.0055 0.0097
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0065 0.0034 0.006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0047 0.0022 0.0019
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.8167 0.5695 1
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0004 0.0004
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.1764 0.1222 0.2145
Echinococcus granulosus microtubule associated protein 2 0.2067 0.1433 0.2517
Echinococcus granulosus lamin 0.0025 0.0006 0.0011
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0004 0.0951
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0219 0.0142 0.0142
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0012 0.0021
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0047 0.0022 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0065 0.0034 0.337
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.0101 0.1673
Onchocerca volvulus Glucosylceramidase homolog 0.0181 0.0116 0.0913
Schistosoma mansoni survival motor neuron protein 0.0096 0.0056 0.0391
Schistosoma mansoni hypothetical protein 0.0035 0.0014 0.0095
Leishmania major DNA polymerase eta, putative 0.0094 0.0055 0.0097
Brugia malayi ImpB/MucB/SamB family protein 0.0094 0.0055 0.0055
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0003 0.0015
Giardia lamblia DINP protein human, muc B family 0.0065 0.0034 0.8477
Plasmodium vivax hypothetical protein, conserved 0.0138 0.0086 1
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0182 0.7923
Echinococcus multilocularis GPCR, family 2 0.0219 0.0142 0.025
Brugia malayi RNA recognition motif domain containing protein 0.0464 0.0314 0.0314
Onchocerca volvulus 0.1764 0.1222 1
Onchocerca volvulus 0.0271 0.0179 0.1431
Echinococcus granulosus tar DNA binding protein 0.0464 0.0314 0.0551
Mycobacterium tuberculosis Conserved protein 0.0138 0.0086 0.1413
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0035 0.0245
Schistosoma mansoni choline o-acyltransferase 0.1764 0.1222 0.8522
Schistosoma mansoni terminal deoxycytidyl transferase 0.0065 0.0034 0.0238
Schistosoma mansoni hypothetical protein 0.0096 0.0056 0.0391
Trypanosoma brucei unspecified product 0.0065 0.0034 0.0174
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0004 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0047 0.0022 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0022 0.0004 0.0487
Brugia malayi nuclear hormone receptor 0.0022 0.0004 0.0004
Schistosoma mansoni tar DNA-binding protein 0.0464 0.0314 0.2187
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Brugia malayi hypothetical protein 0.0025 0.0006 0.0006
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0003 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Loa Loa (eye worm) thioredoxin reductase 0.0045 0.0021 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0019 0.0033
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.1764 0.1222 0.1219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0138 0.0086 0.0597
Trichomonas vaginalis inositol monophosphatase, putative 0.0032 0.0012 0.051
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0047 0.0022 0.0022
Leishmania major DNA damage repair protein, putative 0.002 0.0003 0.0005
Onchocerca volvulus Bile acid receptor homolog 0.0047 0.0022 0.0142
Schistosoma mansoni hypothetical protein 0.0377 0.0253 0.1763
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0047 0.0022 0.0038
Brugia malayi nuclear hormone receptor 0.0047 0.0022 0.0022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0065 0.0034 0.0564
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.3284 0.2284 0.401
Echinococcus multilocularis tar DNA binding protein 0.0464 0.0314 0.0551
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0004 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0022 0.0151
Brugia malayi Proteasome A-type and B-type family protein 0.0073 0.004 0.004
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0044 0.0223
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0073 0.004 0.0281
Plasmodium falciparum glutathione reductase 0.0045 0.0021 0.4722
Echinococcus granulosus neuropeptide s receptor 0.0871 0.0598 0.105
Brugia malayi Steroid receptor seven-up type 2 0.0047 0.0022 0.0022
Brugia malayi CXXC zinc finger family protein 0.0031 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Plasmodium falciparum thioredoxin reductase 0.0045 0.0021 0.4722
Leishmania major carnitine palmitoyltransferase-like protein 0.2825 0.1963 0.3447
Mycobacterium ulcerans aldehyde dehydrogenase 0.0056 0.0028 0.2795
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0047 0.0022 0.0142
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0138 0.0086 0.1413
Echinococcus granulosus L aminoadipate semialdehyde 0.0077 0.0043 0.0075
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0083
Mycobacterium tuberculosis Probable esterase LipL 0.0138 0.0086 0.1413
Onchocerca volvulus 0.0047 0.0022 0.0142
Echinococcus granulosus dna polymerase eta 0.0094 0.0055 0.0097
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0083
Echinococcus multilocularis FTZ F1 alpha 0.0047 0.0022 0.0038
Brugia malayi MH2 domain containing protein 0.02 0.0129 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Brugia malayi RNA binding protein 0.0464 0.0314 0.0314
Echinococcus granulosus ecdysone induced protein 78C 0.0047 0.0022 0.0038
Entamoeba histolytica hypothetical protein 0.014 0.0087 1
Mycobacterium ulcerans hypothetical protein 0.0161 0.0101 1
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.2825 0.1963 0.1963
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0044 1
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.1764 0.1222 0.6223
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0034 0.006
Brugia malayi hypothetical protein 0.0022 0.0004 0.0004
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0003 0.0015
Leishmania major hypothetical protein, conserved 0.0078 0.0044 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0047 0.0022 0.0022
Brugia malayi nuclear receptor RXR 0.0025 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0219 0.0142 0.0992
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0006 0.0006
Echinococcus granulosus proteasome prosome macropain 0.0073 0.004 0.0071
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0065 0.0034 0.1489
Onchocerca volvulus 0.0138 0.0086 0.0667
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0006 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0219 0.0142 0.025
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0047 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0138 0.0086 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0044 0.5118
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0219 0.0142 0.025
Brugia malayi conserved hypotetical protein 0.0022 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0032 0.0012 0.051
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0103 0.0061 0.1011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0047 0.0022 0.0038
Leishmania major proteasome beta 5 subunit, putative 0.0073 0.004 0.0071
Brugia malayi beta-lactamase family protein 0.0138 0.0086 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0138 0.0086 0.373
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0029 0.0009 0.0154
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1764 0.1222 0.1222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0004 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0219 0.0142 0.025
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0032 0.0012 0.0021
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0004 0.0008
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0065 0.0034 0.0238
Trichomonas vaginalis penicillin-binding protein, putative 0.0138 0.0086 0.373
Schistosoma mansoni coup transcription factor 0.0047 0.0022 0.0151
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0883 0.0606 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0004 0.0004
Echinococcus granulosus intermediate filament protein 0.0025 0.0006 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0004 0.0031
Onchocerca volvulus Protein ultraspiracle homolog 0.0047 0.0022 0.0142
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.0182 0.0179
Echinococcus granulosus dna polymerase kappa 0.0065 0.0034 0.006
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0006 0.0006
Mycobacterium ulcerans beta-lactamase 0.0138 0.0086 0.8443
Onchocerca volvulus 0.0138 0.0086 0.0667
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.8167 0.5695 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0032 0.0012 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0014 0.0024
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0003 0.0355
Toxoplasma gondii aldehyde dehydrogenase 0.0056 0.0028 0.331
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.0182 0.0182
Onchocerca volvulus 0.1764 0.1222 1
Echinococcus multilocularis choline O acetyltransferase 0.1764 0.1222 0.2145
Leishmania major trypanothione reductase 0.0045 0.0021 0.0036
Echinococcus granulosus GPCR family 2 0.0219 0.0142 0.025
Echinococcus multilocularis ecdysone induced protein 78C 0.0047 0.0022 0.0038
Loa Loa (eye worm) inositol-1 0.0032 0.0012 0.0009
Mycobacterium tuberculosis Probable hydrolase 0.0138 0.0086 0.1413
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Entamoeba histolytica hypothetical protein 0.014 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0044 0.0041
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0022 0.0004 0.0411
Entamoeba histolytica deoxycytidyl transferase, putative 0.0065 0.0034 0.3634
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0047 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0003
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0004 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0044 1
Mycobacterium ulcerans esterase/lipase LipP 0.0138 0.0086 0.8443
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0047 0.0022 0.0038
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0004 0.0008
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0004 0.0031
Trypanosoma cruzi hypothetical protein, conserved 0.1764 0.1222 0.2145
Trypanosoma cruzi DNA polymerase eta, putative 0.005 0.0024 0.0042
Mycobacterium tuberculosis Conserved protein 0.0138 0.0086 0.1413
Brugia malayi nuclear receptor NHR-88 0.0022 0.0004 0.0004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0136 0.0084 0.0081
Trichomonas vaginalis D-aminoacylase, putative 0.0138 0.0086 0.373
Schistosoma mansoni cpg binding protein 0.0031 0.001 0.0072
Schistosoma mansoni nuclear hormone receptor 0.0047 0.0022 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.0182 0.7923
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0003 0.0694
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0028 0.0198
Echinococcus granulosus inositol monophosphatase 1 0.0032 0.0012 0.0021
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0006 0.0003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0013 0.0023
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0026 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0047 0.0022 0.0022
Echinococcus granulosus lamin dm0 0.0025 0.0006 0.0011
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0004 0.0001
Plasmodium falciparum proteasome subunit beta type-5 0.0073 0.004 0.9201
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0047 0.0022 0.0038
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0045 0.0021 0.0341
Mycobacterium tuberculosis Conserved hypothetical protein 0.0065 0.0034 0.0564
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0003 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0047 0.0022 0.0019
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0073 0.004 0.0071
Schistosoma mansoni aldehyde dehydrogenase 0.0056 0.0028 0.0198
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0034 0.006
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0136 0.0084 0.0587
Plasmodium vivax glutathione reductase, putative 0.0045 0.0021 0.2417
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0047 0.0022 0.0022
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0073 0.004 0.0665
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0219 0.0142 0.0139
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0003 0.0005
Trypanosoma brucei unspecified product 0.0045 0.002 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0065 0.0034 0.0174
Trypanosoma cruzi DNA polymerase kappa, putative 0.0065 0.0034 0.006
Echinococcus multilocularis neuropeptide s receptor 0.0871 0.0598 0.105
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0073 0.004 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0006 0.0044
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0047 0.0022 0.0019
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0014 0.0024
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0022 0.0022
Trichomonas vaginalis D-aminoacylase, putative 0.0138 0.0086 0.373
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0013 0.0093
Mycobacterium ulcerans hypothetical protein 0.002 0.0003 0.03
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0047 0.0022 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0022 0.0004 0.0021
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0022 0.0004 0.0487
Brugia malayi Inositol-1 0.0032 0.0012 0.0012
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.1764 0.1222 0.2145
Schistosoma mansoni thyroid hormone receptor 0.0047 0.0022 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0047 0.0022 0.0038
Schistosoma mansoni hypothetical protein 0.014 0.0087 0.0605
Loa Loa (eye worm) steroid hormone receptor 0.0047 0.0022 0.0019
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0047 0.0022 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0047 0.0022 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0004 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0019 0.0033
Loa Loa (eye worm) TAR-binding protein 0.0464 0.0314 0.0311
Brugia malayi polk-prov protein 0.002 0.0003 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0116 0.5034
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0065 0.0034 0.006
Echinococcus multilocularis proteasome (prosome, macropain) 0.0073 0.004 0.0071
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.0202 0.0355
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.2825 0.1963 0.196
Schistosoma mansoni cpg binding protein 0.0032 0.0012 0.0081
Schistosoma mansoni hypothetical protein 0.0219 0.0142 0.0992
Giardia lamblia DNA damage repair protein 0.002 0.0003 0.0754
Schistosoma mansoni choline o-acyltransferase 0.1764 0.1222 0.8522
Loa Loa (eye worm) choline O-acetyltransferase 0.1764 0.1222 0.1219
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0047 0.0022 0.0038
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Onchocerca volvulus 0.0096 0.0056 0.0425
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0029 0.0009 0.0634
Toxoplasma gondii hypothetical protein 0.0049 0.0023 0.2738
Onchocerca volvulus 0.0025 0.0006 0.0017
Brugia malayi hypothetical protein 0.014 0.0087 0.0087
Echinococcus multilocularis lamin dm0 0.0025 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0163 0.0103 0.01
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0044 0.0077
Loa Loa (eye worm) hypothetical protein 0.0047 0.0022 0.0019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0138 0.0086 0.015
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0138 0.0086 0.1413
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0004 0.0008
Mycobacterium leprae Probable lipase LipE 0.0138 0.0086 1
Mycobacterium ulcerans lipase LipD 0.0138 0.0086 0.8443
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0004 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0047 0.0022 0.0151
Trypanosoma brucei unspecified product 0.0045 0.002 0.0103
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0006 0.0003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0065 0.0034 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0136 0.0084 0.0148
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0013 0.0023

Activities

Activity type Activity value Assay description Source Reference
Bmax (binding) = 7.4 pmol Binding affinity to mu opioid receptor expressed in CHO cells assessed per mg of protein ChEMBL. 19113864
Bmax (binding) = 9.3 pmol Binding affinity to CCK2R-MOPR coexpressed in CHO cells assessed per mg of protein by [3H]DAMGO displacement assay ChEMBL. 19113864
Bmax (binding) = 10.9 pmol Binding affinity to CCK2R-MOPR coexpressed in CHO cells assessed per mg of protein by [125I] CCK-26-33 displacement assay ChEMBL. 19113864
Bmax (binding) = 18.5 pmol Binding affinity to CCK2 receptor expressed in CHO cells assessed per mg of protein ChEMBL. 19113864
ED50 (functional) = 64.33 pmol Antinociceptive activity in icv dosed ICR mouse after 24 hrs by tail flick assay ChEMBL. 19113864
ED50 (functional) = 2020 pmol Antinociceptive activity in icv dosed ICR mouse by tail flick assay ChEMBL. 19113864
Ki (binding) = 16.3 nM Displacement of [3H]DAMGO from CCK2R-MOPR coexpressed in CHO cells ChEMBL. 19113864
Ki (binding) = 29.4 nM Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells ChEMBL. 19113864
Ki (binding) = 77 nM Displacement of [125I]CCK-26-33 from CCK2R-MOPR coexpressed in CHO cells ChEMBL. 19113864
Ki (binding) = 260 nM Displacement of [125I]CCK-26-33 from CCK2 receptor expressed in CHO cells ChEMBL. 19113864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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