Detailed information for compound 1202618

Basic information

Technical information
  • TDR Targets ID: 1202618
  • Name: 2-(3,5-dimethylpiperidin-1-yl)-7-phenyl-7,8-d ihydro-6H-quinazolin-5-one
  • MW: 335.443 | Formula: C21H25N3O
  • H donors: 0 H acceptors: 3 LogP: 3.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CC(C)CN(C1)c1ncc2c(n1)CC(CC2=O)c1ccccc1
  • InChi: 1S/C21H25N3O/c1-14-8-15(2)13-24(12-14)21-22-11-18-19(23-21)9-17(10-20(18)25)16-6-4-3-5-7-16/h3-7,11,14-15,17H,8-10,12-13H2,1-2H3
  • InChiKey: BXEYNVPEAPCUBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(3,5-dimethyl-1-piperidyl)-7-phenyl-7,8-dihydro-6H-quinazolin-5-one
  • 2-(3,5-dimethyl-1-piperidinyl)-7-phenyl-7,8-dihydro-6H-quinazolin-5-one
  • SMR000045365
  • MLS000040665

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi diacylglycerol acyltransferase 0.0123 0.0691 0.1061
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0073 0.0381 0.2417
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0061 0.0058
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.0049 0.0054
Toxoplasma gondii hypothetical protein 0.0042 0.0181 0.2305
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0143 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.1691 0.2611
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.0019 0.0023
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0017 0.0029 0.0022
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0185 0.0282
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0005
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.0049 0.0076
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.0578 0.0886
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0381 0.1988
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni biogenic amine receptor 0.0022 0.0061 0.0072
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0123 0.0691 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0294
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Brugia malayi Glycosylation related protein 12, isoform 0.0036 0.0143 0.0212
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0061 0.0072
Brugia malayi chromobox protein homolog 3 0.0041 0.0179 0.0268
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Onchocerca volvulus 0.0022 0.0061 0.0086
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0061 0.0058
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Mycobacterium ulcerans hypothetical protein 0.0162 0.094 1
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Mycobacterium tuberculosis Conserved protein 0.0073 0.0381 0.1252
Loa Loa (eye worm) tyrosyl-tRNA synthetase 0.0036 0.0145 0.0224
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0381 0.1252
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0805 0.0802
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0061 0.0058
Brugia malayi G protein-coupled receptor 0.0022 0.0061 0.0085
Onchocerca volvulus 0.0032 0.0123 0.0539
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0039 0.017
Schistosoma mansoni histamine h1 receptor 0.0022 0.0061 0.0072
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0224 0.0347
Brugia malayi intermediate filament protein 0.0028 0.0093 0.0134
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0062 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0097
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0049 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus allatostatin A receptor 0.0022 0.0061 0.009
Onchocerca volvulus 0.0022 0.0061 0.0086
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Onchocerca volvulus 0.0022 0.0061 0.0086
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0381 0.1252
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0071 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.0325
Trypanosoma cruzi GUP1, putative 0.0021 0.0049 0.0189
Schistosoma mansoni biogenic amine receptor 0.0022 0.0061 0.0072
Echinococcus multilocularis neuropeptide receptor A26 0.0578 0.3555 0.3553
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0107
Brugia malayi Pre-SET motif family protein 0.0206 0.1215 0.1873
Toxoplasma gondii tRNA ligases class I (M) protein 0.0022 0.0059 0.0451
Onchocerca volvulus 0.0028 0.0093 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0049 0.0244
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0061 0.0072
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0292 0.0448
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0381 0.265
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0069 0.0398
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0179 0.1188
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0061 0.0085
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0027 0.0092 0.0419
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0061 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Loa Loa (eye worm) methionyl-tRNA synthetase 0.0058 0.0283 0.0439
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni chromobox protein 0.0074 0.0383 0.0572
Plasmodium vivax methionine--tRNA ligase, putative 0.0058 0.0283 0.3823
Echinococcus multilocularis serotonin receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0061 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0381 0.1988
Onchocerca volvulus 0.0042 0.0185 0.0989
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0049 0.0046
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0308 0.1857 1
Echinococcus granulosus g protein coupled receptor 0.0022 0.0061 0.009
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0061 0.009
Echinococcus granulosus lamin 0.0028 0.0093 0.0139
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi hypothetical protein 0.0025 0.0074 0.0105
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0252 0.1287
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0192 0.0963
Mycobacterium tuberculosis Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 0.0058 0.0283 0.0909
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Echinococcus granulosus fmrfamide receptor 0.0022 0.0061 0.009
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0074 0.0691
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0069 0.044
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0307 0.4197
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi Bromodomain containing protein 0.0038 0.0157 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0381 0.0568
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1691 0.2602
Brugia malayi Hhat protein 0.0021 0.0049 0.0066
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.0058
Leishmania major diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0061 0.0072
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0369 0.0567
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Trichomonas vaginalis esterase, putative 0.0073 0.0381 0.265
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0638
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0049 0.0189
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1691 0.1688
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0078 0.0412 0.0616
Mycobacterium ulcerans methionyl-tRNA synthetase 0.0058 0.0283 0.2795
Onchocerca volvulus 0.0022 0.0061 0.0086
Toxoplasma gondii hypothetical protein 0.0021 0.0049 0.0312
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0381 0.0568
Brugia malayi methionyl-tRNA synthetase 0.0022 0.0059 0.0081
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Echinococcus granulosus family S10 non peptidase ue S10 family 0.0025 0.0075 0.0111
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0049 0.0072
Chlamydia trachomatis methionine--tRNA ligase 0.0022 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Brugia malayi AKH receptor 0.0022 0.0061 0.0085
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0294
Brugia malayi Dopamine receptor protein 1 0.0022 0.0061 0.0085
Loa Loa (eye worm) hhat protein 0.0021 0.0049 0.0076
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0185 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Schistosoma mansoni family S10 unassigned peptidase (S10 family) 0.0027 0.0092 0.012
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0061 0.0058
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.0837 0.4461
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0049 0.0046
Brugia malayi G-protein coupled receptor 0.0022 0.0061 0.0085
Onchocerca volvulus 0.0022 0.0061 0.0086
Schistosoma mansoni alpha-13-mannosyl-glycoprotein beta-1 2-n-acetylglucosaminyltransferase 0.0105 0.0579 0.0875
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0093 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0091
Loa Loa (eye worm) hypothetical protein 0.0044 0.0195 0.0302
Loa Loa (eye worm) hypothetical protein 0.0028 0.0093 0.0144
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0093 0.0144
Mycobacterium leprae Probable lipase LipE 0.0073 0.0381 1
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0234 0.1393 0.9799
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0224 0.0338
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0381 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Schistosoma mansoni hypothetical protein 0.0021 0.0049 0.0054
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0049 0.0046
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0143 0.0216
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.0058
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0016 0.0018 0.0015
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0061 0.009
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0381 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Onchocerca volvulus 0.0239 0.1421 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0837 0.4461
Wolbachia endosymbiont of Brugia malayi methionyl-tRNA synthetase 0.0058 0.0283 1
Schistosoma mansoni patched 1 0.0042 0.0185 0.0265
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.0656
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0061 0.0058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0292 0.0289
Echinococcus granulosus sex peptide receptor 0.0022 0.0061 0.009
Onchocerca volvulus 0.0022 0.0061 0.0086
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0185 0.1232
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0022 0.0061 0.0086
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Brugia malayi RE15519p 0.0022 0.0061 0.0085
Toxoplasma gondii exonuclease III APE 0.0023 0.0062 0.0511
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0061 0.009
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0093 0.0134
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0061 0.0058
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Onchocerca volvulus 0.0049 0.0231 0.1323
Brugia malayi neuropeptide F receptor 0.0022 0.0061 0.0085
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0199 0.1092
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0074 0.0325
Brugia malayi CHE-14 protein 0.0042 0.0185 0.0277
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Schistosoma mansoni hypothetical protein 0.0017 0.0029 0.0022
Echinococcus granulosus expressed conserved protein 0.0093 0.0501 0.0772
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0294
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0369 0.0366
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1857 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0292 0.0941
Brugia malayi putative neuropeptide receptor 0.0022 0.0061 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0381 0.1988
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0123 0.0691 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0185 0.0287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0061 0.009
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0016 0.0018 0.0024
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0025 0.0022
Echinococcus multilocularis leucyl tRNA synthetase 0.0022 0.0059 0.0055
Onchocerca volvulus 0.0022 0.0061 0.0086
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0199 0.1331
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0022 0.0059 0.0086
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0061 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0329 0.227
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0061 0.0058
Leishmania major mitochondrial DNA polymerase beta 0.0308 0.1857 1
Onchocerca volvulus 0.0022 0.0061 0.0086
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0062 0.0059
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0062 0.0269
Onchocerca volvulus 0.0022 0.0061 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0292 0.2894
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0292 0.0431
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0061 0.009
Brugia malayi PHD-finger family protein 0.0026 0.0085 0.0122
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0049 0.0076
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0061 0.0095
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0061 0.0085
Schistosoma mansoni bromodomain containing protein 0.0064 0.0323 0.0479
Toxoplasma gondii dgat2l1-prov protein 0.0078 0.0412 0.5782
Echinococcus granulosus methionine tRNA synthetase 0.0058 0.0283 0.0434
Brugia malayi G-protein coupled receptor 0.0022 0.0061 0.0085
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0059 0.0415
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0061 0.009
Schistosoma mansoni biogenic amine receptor 0.0022 0.0061 0.0072
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0192 0.0963
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0185 0.0282
Onchocerca volvulus 0.0022 0.0061 0.0086
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0381 0.3864
Trypanosoma cruzi GUP1, putative 0.0021 0.0049 0.0189
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0061 0.0085
Toxoplasma gondii methionyl-tRNA synthetase 0.0058 0.0283 0.3846
Schistosoma mansoni diacylglycerol O-acyltransferase 0.0017 0.0029 0.0022
Onchocerca volvulus 0.0078 0.0412 0.2642
Mycobacterium tuberculosis Conserved protein 0.0073 0.0381 0.1252
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0179 0.1188
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0061 0.009
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Schistosoma mansoni opsin-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.0883 0.1367
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.009
Onchocerca volvulus 0.0073 0.0381 0.2417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0224 0.0347
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0061 0.0085
Mycobacterium ulcerans lipase LipD 0.0073 0.0381 0.3864
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0061 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0381 0.5299
Plasmodium falciparum methionine--tRNA ligase 0.0058 0.0283 0.3823
Onchocerca volvulus 0.0028 0.0093 0.0316
Mycobacterium tuberculosis Conserved protein 0.0073 0.0381 0.1252
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0022 0.0059 0.0328
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Echinococcus multilocularis geminin 0.0167 0.0971 0.0968
Loa Loa (eye worm) hypothetical protein 0.0102 0.0561 0.0869
Brugia malayi Serotonin receptor 0.0022 0.0061 0.0085
Schistosoma mansoni leucyl-tRNA synthetase 0.0022 0.0059 0.0068
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0069 0.044
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0036 0.0145 0.0694
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Schistosoma mansoni myosin xvIII 0.0022 0.0061 0.0072
Schistosoma mansoni family S10 non-peptidase homologue (S10 family) 0.0027 0.0092 0.012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0061 0.0085
Schistosoma mansoni methionine-tRNA synthetase 0.0058 0.0283 0.0417
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0383 0.2666
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0109 0.1214
Schistosoma mansoni methionine-tRNA synthetase 0.0022 0.0059 0.0068
Plasmodium vivax methionine--tRNA ligase, putative 0.0022 0.0059 0.0415
Onchocerca volvulus 0.0022 0.0061 0.0086
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0069 0.0398
Onchocerca volvulus Huntingtin homolog 0.0131 0.0743 0.5055
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0025 0.0017
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0188
Echinococcus granulosus alpha 16 mannosyl glycoprotein 0.104 0.6458 1
Trypanosoma cruzi methionyl-tRNA synthetase, putative 0.0058 0.0283 0.1459
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1691 0.2615
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0224 0.0343
Echinococcus granulosus lamin dm0 0.0028 0.0093 0.0139
Toxoplasma gondii Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 0.0036 0.0143 0.1729
Loa Loa (eye worm) pax transcription factor protein 2 0.0239 0.1421 0.22
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0113 0.0174
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.0883 0.1358
Brugia malayi larval opioid receptor 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.0539 0.0825
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.044
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Echinococcus multilocularis serotonin receptor 0.0022 0.0061 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis sex peptide receptor 0.0022 0.0061 0.0058
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0061 0.0072
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus multilocularis expressed conserved protein 0.0093 0.0501 0.0498
Treponema pallidum methionyl-tRNA synthetase 0.0022 0.0059 0.6987
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis somatostatin receptor 0.0022 0.0061 0.0058
Leishmania major hypothetical protein, conserved 0.0025 0.0074 0.0325
Brugia malayi diacylglycerol acyltransferase family protein 0.0078 0.0412 0.0628
Giardia lamblia Methionyl-tRNA synthetase 0.0058 0.0283 1
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0062 0.0097
Echinococcus multilocularis neuropeptide s receptor 0.0578 0.3555 0.3553
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0061 0.0085
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0074 0.0656
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0123 0.0691 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0061 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0061 0.0072
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0025 0.0035
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0061 0.0058
Brugia malayi beta-lactamase family protein 0.0073 0.0381 0.058
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0031 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0369 0.055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0109 0.0147
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi sulfakinin receptor protein 0.0022 0.0061 0.0085
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.0049 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0215 0.0311
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.0539 0.083
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Entamoeba histolytica methionyl-tRNA synthetase, putative 0.0022 0.0059 0.0188
Onchocerca volvulus 0.0022 0.0061 0.0086
Echinococcus multilocularis microtubule associated protein 2 0.0674 0.4157 0.4155
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0049 0.0189
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.044
Trypanosoma brucei serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.0049 0.0072
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0049 0.0189
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0292 0.3982
Mycobacterium leprae Probable methionyl-tRNA synthase MetS 0.0058 0.0283 0.6877
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0638
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.0049 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0061 0.0072
Onchocerca volvulus 0.0022 0.0061 0.0086
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0049 0.0054
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0123 0.0691 0.105
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0061 0.009
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0381 0.3864
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0049 0.0244
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Leishmania major diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Echinococcus granulosus lysosomal protective protein 0.0027 0.0092 0.0137
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi beta-lactamase 0.0073 0.0381 0.058
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0016 0.0019 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0062 0.0087
Loa Loa (eye worm) hypothetical protein 0.0131 0.0743 0.115
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0805 0.1242
Echinococcus granulosus zinc finger protein 0.0021 0.0052 0.0076
Echinococcus multilocularis methionine tRNA synthetase 0.0058 0.0283 0.028
Brugia malayi Heterochromatin protein 1 0.0074 0.0383 0.0584
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0049 0.0054
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0091
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0381 0.1252
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0061 0.0095
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1691 0.2602
Brugia malayi Pre-SET motif family protein 0.003 0.0109 0.0159
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0061 0.0095
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0152
Loa Loa (eye worm) hypothetical protein 0.0052 0.0245 0.038
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Brugia malayi CHD4 protein 0.0016 0.0018 0.0018
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Brugia malayi Serotonin receptor 0.0022 0.0061 0.0085
Echinococcus granulosus dnaJ subfamily B 0.0437 0.2667 0.4128
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0049 0.0076
Brugia malayi Dopamine receptor 0.0022 0.0061 0.0085
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0048 0.0074
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0061 0.0058
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0061 0.0095
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0549 0.0829
Schistosoma mansoni ap endonuclease 0.0023 0.0062 0.0074
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0381 0.1252
Toxoplasma gondii hypothetical protein 0.005 0.0232 0.3072
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis methionine-tRNA synthetase, putative 0.0058 0.0283 0.1943
Echinococcus multilocularis protein dispatched 1 0.0048 0.0223 0.022
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0021 0.0049 0.0072
Mycobacterium ulcerans hypothetical protein 0.0073 0.0381 0.3864
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi hypothetical protein 0.0016 0.002 0.002
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0061 0.0058
Schistosoma mansoni sterol O-acyltransferase 1 0.0021 0.0049 0.0054
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0179 0.0949
Schistosoma mansoni adenoreceptor 0.0022 0.0061 0.0072
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1691 0.1688
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.0837 0.4461
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0012 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0012 0.0009
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0062 0.0092
Onchocerca volvulus Huntingtin homolog 0.0131 0.0743 0.5055
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0071 0.0104
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.0656
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0381 0.0585
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0016 0.0018 0.0006
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi Pax transcription factor protein 2 0.0239 0.1421 0.2192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0061 0.0058
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0049 0.0189
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0061 0.0058
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.0049 0.0046
Schistosoma mansoni microtubule-associated protein tau 0.0674 0.4157 0.6428
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0061 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Echinococcus multilocularis alpha 1,6 mannosyl glycoprotein 0.104 0.6458 0.6457
Echinococcus granulosus GPCR family 2 0.0048 0.0224 0.0343
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0061 0.0058
Leishmania major hypothetical protein, conserved 0.0021 0.0049 0.0189
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0381 0.1252
Brugia malayi neuropeptide F receptor 0.0022 0.0061 0.0085
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0061 0.009
Echinococcus multilocularis lysosomal protective protein 0.0027 0.0092 0.0089
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Mycobacterium ulcerans hypothetical protein 0.0024 0.0069 0.044
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0069 0.0398
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0123 0.0691 0.107
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Onchocerca volvulus 0.0031 0.0113 0.0461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0308 0.1857 1
Schistosoma mansoni chromobox protein 0.0074 0.0383 0.0572
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.0049 0.0054
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1691 0.2615
Loa Loa (eye worm) hypothetical protein 0.007 0.0358 0.0555
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0062 0.0475
Loa Loa (eye worm) hypothetical protein 0.0131 0.0743 0.115
Leishmania major leucyl-tRNA synthetase, putative 0.0022 0.0059 0.0238
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0069 0.0154
Echinococcus multilocularis lamin 0.0028 0.0093 0.009
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0078 0.0412 0.0637
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0381 0.0378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.2866 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0059 0.0091
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Echinococcus granulosus hypothetical protein 0.0022 0.0061 0.009
Leishmania major diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Trichomonas vaginalis porcupine, putative 0.0021 0.0049 0.0244
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0061 0.0058
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0049 0.0189
Brugia malayi UDP-GlcNAc:a-6-D-mannoside b1,2-N-acetylglucosaminyltransferase II 0.104 0.6458 1
Echinococcus granulosus alpha 13 mannosyl glycoprotein 0.0105 0.0579 0.0892
Onchocerca volvulus 0.0022 0.0061 0.0086
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Echinococcus granulosus neuropeptide receptor 0.0022 0.0061 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0062 0.026
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0215 0.0328
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Echinococcus granulosus orexin receptor type 2 0.0022 0.0061 0.009
Brugia malayi hypothetical protein 0.0071 0.0369 0.0562
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0061 0.009
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0062 0.0339
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0071 0.0067
Leishmania major glycerol uptake protein, putative 0.0021 0.0049 0.0189
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0061 0.0085
Brugia malayi Serine carboxypeptidase F41C3.5 precursor 0.0027 0.0092 0.0132
Echinococcus granulosus somatostatin receptor 0.0022 0.0061 0.009
Onchocerca volvulus 0.0073 0.0381 0.2417
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0381 0.1252
Brugia malayi hypothetical protein 0.0131 0.0743 0.1141
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0123 0.0691 0.1066
Schistosoma mansoni hypothetical protein 0.0071 0.0369 0.055
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0061 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0061 0.0072
Mycobacterium ulcerans beta-lactamase 0.0073 0.0381 0.3864
Echinococcus multilocularis alpha 1,3 mannosyl glycoprotein 0.0105 0.0579 0.0576
Schistosoma mansoni zinc finger protein 0.0021 0.0049 0.0054
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0061 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0336 0.0498
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0185 0.0182
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0381 0.265
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0098 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0381 0.265
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0139
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0062 0.0339
Leishmania major methionyl-tRNA synthetase, putative 0.0058 0.0283 0.1459
Echinococcus granulosus geminin 0.0167 0.0971 0.1499
Brugia malayi GNT-I family protein 0.0105 0.0579 0.0887
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0031 0.0027
Brugia malayi follicle stimulating hormone receptor 0.03 0.1808 0.2792
Loa Loa (eye worm) hypothetical protein 0.0105 0.0579 0.0896
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus multilocularis musashi 0.0028 0.0093 0.009
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0222
Echinococcus granulosus neuropeptide receptor A26 0.0578 0.3555 0.5502
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0069 0.044
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0041 0.0179 0.0278
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0061 0.009
Brugia malayi Bromodomain containing protein 0.0076 0.0396 0.0604
Leishmania major hypothetical protein, unknown function,protein, unknown function 0.0017 0.0029 0.0076
Loa Loa (eye worm) hypothetical protein 0.0105 0.0578 0.0895
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0049 0.0076
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Onchocerca volvulus Uncharacterized serine carboxypeptidase homolog 0.0027 0.0092 0.0309
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0383 0.2666
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0027 0.0092 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0049 0.0244
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0381 0.265
Treponema pallidum leucyl-tRNA synthetase 0.0022 0.0059 0.6987
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0333
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0215 0.0311
Loa Loa (eye worm) beta-lactamase 0.0073 0.0381 0.059
Schistosoma mansoni opsin-like receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0031 0.0048
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0292 0.1508
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0292 0.2894
Echinococcus granulosus intermediate filament protein 0.0028 0.0093 0.0139
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.059
Schistosoma mansoni intermediate filament proteins 0.0028 0.0093 0.0121
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0123 0.0691 0.0688
Trichomonas vaginalis transmembrane protein nessy, putative 0.0021 0.0049 0.0244
Loa Loa (eye worm) hypothetical protein 0.0049 0.0231 0.0357
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0185 0.0264
Schistosoma mansoni hypothetical protein 0.0167 0.0971 0.1484
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus multilocularis chromobox protein 1 0.0074 0.0383 0.038
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0301 0.0461
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0061 0.009
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0192 0.0963
Onchocerca volvulus 0.0024 0.0069 0.0142
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0061 0.0058
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1393 1
Echinococcus granulosus chromobox protein 1 0.0074 0.0383 0.0589
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0062 0.0176
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0381 0.059
Echinococcus multilocularis family S10 non peptidase ue (S10 family) 0.0025 0.0075 0.0072
Toxoplasma gondii ABC1 family protein 0.0073 0.0381 0.5317
Echinococcus granulosus sterol O acyltransferase 1 0.0021 0.0049 0.0072
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1215 0.1881
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0231 0.0336
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0199 0.1331
Schistosoma mansoni lamin 0.0028 0.0093 0.0121
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0061 0.0058
Plasmodium vivax SET domain protein, putative 0.003 0.0109 0.1181
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0292 0.2894
Schistosoma mansoni hypothetical protein 0.0105 0.0578 0.0874
Echinococcus granulosus g protein coupled receptor 0.0022 0.0061 0.009
Entamoeba histolytica hypothetical protein 0.0071 0.0369 0.6532
Plasmodium falciparum methionine--tRNA ligase, putative 0.0022 0.0059 0.0415
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.0539 0.0536
Loa Loa (eye worm) hypothetical protein 0.0105 0.0579 0.0896
Echinococcus granulosus tumor protein p63 0.0338 0.2045 0.3164
Echinococcus granulosus neuropeptide s receptor 0.0578 0.3555 0.5502
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0381 0.1252
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0062 0.0176
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0224 0.0221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0062 0.0371
Leishmania major serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 0.0027 0.0092 0.0419
Echinococcus multilocularis protein patched 0.0042 0.0185 0.0182
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0383 0.0593
Loa Loa (eye worm) hypothetical protein 0.0032 0.0123 0.0191
Schistosoma mansoni hypothetical protein 0.0022 0.0061 0.0072
Loa Loa (eye worm) follicle stimulating hormone receptor 0.03 0.1808 0.2799
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0061 0.0095
Loa Loa (eye worm) hypothetical protein 0.0153 0.0883 0.1367
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0069 0.0154
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0061 0.0072
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0025 0.0017
Loa Loa (eye worm) hypothetical protein 0.104 0.6458 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0061 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Echinococcus multilocularis zinc finger protein 0.0021 0.0052 0.0049
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0061 0.0095
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0292 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1691 0.2602
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi protein ZK524.3 0.0022 0.0059 0.0081
Trypanosoma cruzi serine peptidase, Clan SC, Family S10, putative 0.0027 0.0092 0.0419
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus microtubule associated protein 2 0.0674 0.4157 0.6435
Echinococcus multilocularis GPCR, family 2 0.0048 0.0224 0.0221
Loa Loa (eye worm) hypothetical protein 0.0038 0.0158 0.0244
Schistosoma mansoni zinc finger protein 0.0021 0.0052 0.0058
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0061 0.0072
Schistosoma mansoni hypothetical protein 0.002 0.0048 0.0051
Echinococcus granulosus cpg binding protein 0.0034 0.0135 0.0205
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0192 0.0963
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0061 0.0058
Trypanosoma brucei methionyl-tRNA synthetase, putative 0.0058 0.0283 0.1459
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0022 0.0059 0.0055
Leishmania major hypothetical protein, conserved 0.0073 0.0381 0.1988
Brugia malayi MBOAT family protein 0.0021 0.0049 0.0066
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0224 0.0338
Schistosoma mansoni opsin-like receptor 0.0022 0.0061 0.0072
Brugia malayi CXXC zinc finger family protein 0.0031 0.0113 0.0164
Echinococcus multilocularis cpg binding protein 0.0034 0.0135 0.0132
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0049 0.0054
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0062 0.026
Echinococcus multilocularis sterol O acyltransferase 1 0.0021 0.0049 0.0046
Loa Loa (eye worm) CHromoDomain protein family member 0.0016 0.0018 0.0028
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0069 0.044
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0097
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0061 0.009
Brugia malayi ORL1-like opioid receptor 0.0022 0.0061 0.0085
Schistosoma mansoni ap endonuclease 0.0023 0.0062 0.0074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0224 0.0343
Echinococcus granulosus g protein coupled receptor 0.0022 0.0061 0.009
Echinococcus granulosus serotonin receptor 0.0022 0.0061 0.009
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0109 0.0106
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Brugia malayi methionyl-tRNA synthetase 0.0058 0.0283 0.0429
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.0049 0.0046
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0061 0.009
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0061 0.009
Brugia malayi Melatonin receptor type 1A 0.0022 0.0061 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0061 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0019 0.0039 0.017
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0019 0.0039 0.017
Schistosoma mansoni amine GPCR 0.0022 0.0061 0.0072
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0123 0.0691 1
Onchocerca volvulus 0.0022 0.0061 0.0086
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0061 0.009
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0061 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0062 0.026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0076
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0062 0.026
Chlamydia trachomatis leucine--tRNA ligase 0.0022 0.0059 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.1691 0.2618
Schistosoma mansoni hypothetical protein 0.0167 0.0971 0.1484
Schistosoma mansoni neuropeptide receptor 0.0022 0.0061 0.0072
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.0325
Onchocerca volvulus 0.0022 0.0061 0.0086
Schistosoma mansoni hypothetical protein 0.0048 0.0224 0.0326
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Onchocerca volvulus 0.0022 0.0061 0.0086
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0381 0.265
Loa Loa (eye worm) hypothetical protein 0.0098 0.0539 0.0835
Echinococcus granulosus chromobox protein 1 0.0074 0.0383 0.0589
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.0539 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0224 0.0221
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0301 0.0298
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0107
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0215 0.0212
Schistosoma mansoni hypothetical protein 0.0437 0.2667 0.4117
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0049 0.0072
Echinococcus multilocularis lamin dm0 0.0028 0.0093 0.009
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0061 0.009
Onchocerca volvulus Neuropeptide F receptor homolog 0.0022 0.0061 0.0086
Loa Loa (eye worm) hhat protein 0.0021 0.0049 0.0076
Brugia malayi GnHR receptor homolog 0.0022 0.0061 0.0085
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0062 0.0132
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.0883 0.1358
Schistosoma mansoni beta-12-n-acetylglucosaminyltransferase II 0.104 0.6458 1
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.059 0.417
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0061 0.009
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0061 0.0058
Brugia malayi hypothetical protein 0.0022 0.0061 0.0085
Schistosoma mansoni cpg binding protein 0.0034 0.0135 0.0188
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.044
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0062 0.0475
Schistosoma mansoni lamin 0.0028 0.0093 0.0121
Brugia malayi Dopamine receptor protein 2 0.0022 0.0061 0.0085
Trypanosoma cruzi serine carboxypeptidase (CBP1), putative 0.0027 0.0092 0.0419
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.0049 0.0072
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0061 0.0072
Trypanosoma brucei diacylglycerol acyltransferase, putative 0.0078 0.0412 0.2155
Brugia malayi beta-lactamase family protein 0.0073 0.0381 0.058
Schistosoma mansoni hypothetical protein 0.0041 0.0176 0.025
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.094 0.3221
Trypanosoma cruzi diacylglycerol acyltransferase, putative 0.0017 0.0029 0.0076
Echinococcus multilocularis dnaJ subfamily B 0.0437 0.2667 0.2665
Echinococcus granulosus neuropeptide receptor 0.0022 0.0061 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0061 0.0058
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0021 0.0049 0.0046
Loa Loa (eye worm) hypothetical protein 0.004 0.0172 0.0267
Loa Loa (eye worm) hypothetical protein 0.0022 0.0061 0.0095
Echinococcus multilocularis tumor protein p63 0.0338 0.2045 0.2043
Echinococcus multilocularis chromobox protein 1 0.0074 0.0383 0.038

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.2512 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.3548 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4716 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (binding) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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