Detailed information for compound 1230742

Basic information

Technical information
  • TDR Targets ID: 1230742
  • Name: 7-benzyl-2-(dichloromethyl)-5,6,7,8-tetrahydr opyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H )-one
  • MW: 380.292 | Formula: C17H15Cl2N3OS
  • H donors: 1 H acceptors: 3 LogP: 4.08 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: ClC(c1nc(O)c2c(n1)sc1c2CCN(C1)Cc1ccccc1)Cl
  • InChi: 1S/C17H15Cl2N3OS/c18-14(19)15-20-16(23)13-11-6-7-22(8-10-4-2-1-3-5-10)9-12(11)24-17(13)21-15/h1-5,14H,6-9H2,(H,20,21,23)
  • InChiKey: DUKANYHAEIZUED-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • MLS000705398
  • SMR000232051

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens core-binding factor, beta subunit No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens runt-related transcription factor 1 Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase No references
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) UDP-3-O-acyl-GlcNAc deacetylase No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Staphylococcus aureus (strain N315) Probable nicotinate-nucleotide adenylyltransferase Starlite/ChEMBL No references
Homo sapiens acid phosphatase 1, soluble Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Plasmodium berghei nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi nicotinamide/nicotinic acid mononucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Candida albicans hypothetical protein Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania mexicana 6-phospho-1-fructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis 6 phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans 3' exon of potential Low molecular weight phosphoTyrosine Phosphatase gene Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic Get druggable targets OG5_131883 All targets in OG5_131883
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) Get druggable targets OG5_126758 All targets in OG5_126758
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Chlamydia trachomatis UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase Get druggable targets OG5_132025 All targets in OG5_132025
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans phosphofructokinase alpha subunit that can functionally substitute for S. cerevisiae PFK1 (YGR240C) Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA Get druggable targets OG5_127571 All targets in OG5_127571
Onchocerca volvulus Get druggable targets OG5_133916 All targets in OG5_133916
Trypanosoma brucei gambiense ATP-dependent phosphofructokinase,6-phospho-1-fructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum hypothetical protein Get druggable targets OG5_131883 All targets in OG5_131883
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans C terminus of potential Low molecular weight phosphoTyrosine Phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Theileria parva hypothetical protein, conserved Get druggable targets OG5_131883 All targets in OG5_131883
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Loa Loa (eye worm) phosphotyrosine protein phosphatase Get druggable targets OG5_127571 All targets in OG5_127571
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_127571 All targets in OG5_127571
Babesia bovis cytidylyltransferase family protein Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Entamoeba histolytica protein tyrosine phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase Get druggable targets OG5_131883 All targets in OG5_131883
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania donovani ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Brugia malayi phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii Predicted nucleotidyltransferase, putative Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC Get druggable targets OG5_131883 All targets in OG5_131883
Schistosoma japonicum ko:K00850 6-phosphofructokinase [EC2.7.1.11], putative Get druggable targets OG5_126758 All targets in OG5_126758
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein Get druggable targets OG5_127571 All targets in OG5_127571
Schistosoma mansoni 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense ATP-dependent 6-phosphofructokinase, glycosomal Get druggable targets OG5_126758 All targets in OG5_126758
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133916 All targets in OG5_133916
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi 6-phosphofructokinase Get druggable targets OG5_126758 All targets in OG5_126758
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans phosphofructokinase beta-subunit that can functionally substitute for S. cerevisiae PFK2 (YMR205C) Get druggable targets OG5_126758 All targets in OG5_126758
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative Get druggable targets OG5_127571 All targets in OG5_127571
Entamoeba histolytica phosphofructokinase, putative Get druggable targets OG5_126758 All targets in OG5_126758
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 205 aa 19.0 %
Trichomonas vaginalis nicotinamide mononucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 210 aa 23.8 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 20.5 %
Entamoeba histolytica NMN adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Entamoeba histolytica nicotinamide nucleotide adenylyltransferase, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 204 aa 24.5 %
Trypanosoma cruzi hypothetical protein, conserved Probable nicotinate-nucleotide adenylyltransferase   189 aa 200 aa 21.0 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Trypanosoma brucei variant surface glycoprotein (VSG, atypical), putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 171 aa 20.5 %
Mycobacterium tuberculosis Probable acyl-[acyl-carrier protein] desaturase DesA1 (acyl-[ACP] desaturase) (stearoyl-ACP desaturase) (protein Des) acid phosphatase 1, soluble 112 aa 107 aa 24.3 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 247 aa 20.6 %
Plasmodium knowlesi cytoskeleton associated protein, putative Probable nicotinate-nucleotide adenylyltransferase   189 aa 170 aa 23.5 %
Giardia lamblia Nicotinamide-nucleotide adenylyltransferase Probable nicotinate-nucleotide adenylyltransferase   189 aa 153 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0604 0.1396
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0987 0.4053
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0307 0.0747
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0606 0.1476
Toxoplasma gondii hypothetical protein 0.0059 0.0518 0.8475
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.025 0.1023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0086 0.0349
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.045 0.045
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0432 0.1069
Echinococcus multilocularis GPCR, family 2 0.0018 0.0047 0.0047
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0114
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0111 0.0111
Schistosoma mansoni polycystin 1-related 0.0022 0.009 0.022
Loa Loa (eye worm) hypothetical protein 0.0056 0.0487 0.0788
Schistosoma mansoni kinase 0.0058 0.0508 0.1238
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0073
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.025 0.0442
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0086 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0028 0.0066
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0086 0.5
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0073
Giardia lamblia DINP protein human, muc B family 0.0023 0.0111 0.0105
Schistosoma mansoni hypothetical protein 0.01 0.099 0.2411
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1349 0.5539
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.0658 0.0658
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0321 0.0795
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0019 0.0061 0.0351
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0658 0.1602
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4026 1
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0139 0.0379
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2434 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2434 0.6705
Trypanosoma brucei polo-like protein kinase 0.0114 0.1152 0.2858
Plasmodium vivax JmjC domain containing protein 0.0019 0.0061 0.0046
Schistosoma mansoni rab6-interacting 0.0022 0.009 0.022
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.4026 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0111 0.0272
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.1349 0.3285
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.031 0.0851
Echinococcus multilocularis muscleblind protein 1 0.0341 0.3753 0.3753
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.099 0.099
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0307 0.1255
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0067 0.0606 0.1503
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.031 0.0851
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0086 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0321 0.0882
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Loa Loa (eye worm) RecQ helicase 0.0026 0.0139 0.0204
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0243 0.3586
Echinococcus multilocularis muscleblind protein 0.0341 0.3753 0.3753
Schistosoma mansoni rab6-interacting 0.0022 0.009 0.022
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0111 0.0272
Brugia malayi Importin beta-1 subunit 0.0035 0.0243 0.0378
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0642 0.1592
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0111 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0067 0.0606 0.0606
Schistosoma mansoni DNA polymerase eta 0.0023 0.0111 0.027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.009 0.009
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0321 0.0634
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1823 0.4526
Leishmania major ATP-dependent phosphofructokinase 0.0131 0.1349 0.3348
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.009 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Loa Loa (eye worm) hypothetical protein 0.003 0.0193 0.0294
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.031 0.0767
Brugia malayi hypothetical protein 0.002 0.0069 0.0087
Trichomonas vaginalis set domain proteins, putative 0.0286 0.3124 0.8607
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0017 0.0044
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.025 0.0507
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0111 0.027
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.009 0.022
Echinococcus granulosus bloom syndrome protein 0.0026 0.0139 0.0338
Brugia malayi hypothetical protein 0.003 0.0193 0.0294
Loa Loa (eye worm) hypothetical protein 0.0535 0.5978 1
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0111 0.0272
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0167 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0086 0.0114
Brugia malayi Doublecortin family protein 0.0022 0.009 0.0123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0606 0.1402
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0193 0.0475
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0378
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0226 0.2434 0.4055
Brugia malayi jmjC domain containing protein 0.0071 0.0658 0.1075
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.1349 0.2234
Loa Loa (eye worm) doublecortin family protein 0.0022 0.009 0.0123
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1152 0.2858
Brugia malayi hypothetical protein 0.0022 0.009 0.0123
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0321 0.0634
Plasmodium falciparum importin beta, putative 0.0035 0.0243 0.0488
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.1152 0.2858
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0307 0.0758
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0019 0.0061 0.0351
Schistosoma mansoni phd/f-box containing protein 0.0019 0.0061 0.0148
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0321 0.0634
Trypanosoma brucei glucosidase, putative 0.0041 0.031 0.0767
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0226 0.2434 0.4055
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.025 0.0686
Loa Loa (eye worm) hypothetical protein 0.004 0.0307 0.0485
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0257 0.0625
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.009 0.009
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0307 0.0841
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0243 0.06
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.031 0.0767
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0432 0.1069
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0073
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0111 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.031 0.0851
Brugia malayi hypothetical protein 0.0022 0.009 0.0123
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0017 0.0044
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0321 0.0634
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0028 0.0066
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0114
Loa Loa (eye worm) glutaminase 2 0.033 0.3629 0.606
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.099 0.2411
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0073
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0111 0.0157
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0321 0.0882
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.025 0.0698
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0111 0.0272
Schistosoma mansoni hypothetical protein 0.0038 0.0283 0.069
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.009 0.022
Echinococcus multilocularis RUN 0.0022 0.009 0.009
Mycobacterium ulcerans beta-lactamase 0.0042 0.0321 0.0634
Leishmania major hypothetical protein, conserved 0.003 0.0193 0.0475
Brugia malayi hypothetical protein 0.0286 0.3118 0.5203
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0321 0.0782
Trypanosoma brucei unspecified product 0.0023 0.0111 0.0272
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0604 0.1471
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0321 0.0321
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0073
Brugia malayi RNA, U transporter 1 0.0099 0.0979 0.1614
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0111 0.0302
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0139 0.0379
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0017 0.0065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0047 0.005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0086 0.0211
Schistosoma mansoni jumonji domain containing protein 0.0019 0.0061 0.0148
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0243 0.0243
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.099 0.099
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.025 0.3716
Trichomonas vaginalis esterase, putative 0.0042 0.0321 0.0882
Treponema pallidum hypothetical protein 0.0345 0.3796 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.045 0.0727
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0226 0.2434 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0111 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.045 0.1097
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0047 0.0114
Brugia malayi jmjC domain containing protein 0.0019 0.0061 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0432 0.1069
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.031 0.1269
Leishmania major DNA polymerase eta, putative 0.0023 0.0111 0.0272
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0139 0.0204
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0017 0.0044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0604 0.1396
Loa Loa (eye worm) glutaminase 0.033 0.3629 0.606
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0047 0.005
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.1349 0.3348
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.025 0.0686
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.031 0.478
Schistosoma mansoni ap endonuclease 0.0021 0.0086 0.021
Echinococcus multilocularis 6 phosphofructokinase 0.0131 0.1349 0.1349
Echinococcus granulosus lysine specific demethylase 6a 0.0019 0.0061 0.0148
Echinococcus granulosus RUN 0.0022 0.009 0.022
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0111 0.0157
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0511 0.0829
Loa Loa (eye worm) hypothetical protein 0.0036 0.0257 0.0402
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.051
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0183 0.1946 0.3236
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0321 0.0634
Loa Loa (eye worm) hypothetical protein 0.0023 0.0111 0.0157
Loa Loa (eye worm) hypothetical protein 0.01 0.099 0.1633
Echinococcus multilocularis jumonji domain containing 1A 0.0019 0.0061 0.0061
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0345 0.3796 1
Loa Loa (eye worm) hypothetical protein 0.0341 0.3753 0.6268
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0321 0.0882
Echinococcus multilocularis JmjC domain containing protein 4 0.0019 0.0061 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.051
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0642 0.1766
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.045 0.0727
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0307 0.0747
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0086 0.0116
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.025 0.0551
Loa Loa (eye worm) hypothetical protein 0.0535 0.5978 1
Schistosoma mansoni ap endonuclease 0.0021 0.0086 0.021
Onchocerca volvulus 0.0022 0.009 0.0123
Brugia malayi hypothetical protein 0.0535 0.5978 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.0658 0.1602
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.031 0.0851
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Echinococcus granulosus dna polymerase eta 0.0023 0.0111 0.027
Loa Loa (eye worm) hypothetical protein 0.0341 0.3753 0.6268
Echinococcus granulosus JmjC domain containing protein 4 0.0019 0.0061 0.0148
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.025 0.0686
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0266 0.2896 0.7574
Schistosoma mansoni glutaminase 0.033 0.3629 0.8838
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0307 0.0758
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.1152 0.4729
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2434 0.6705
Schistosoma mansoni importin beta-1 0.0035 0.0243 0.0591
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.099 0.2411
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0487 0.0788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.045 0.1097
Schistosoma mansoni phosphatidylserine receptor 0.0019 0.0061 0.0148
Onchocerca volvulus 0.0182 0.1936 0.3219
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.045 0.1097
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0047 0.0047
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0307 0.0939
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0131 0.1349 0.3348
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0243 0.06
Trypanosoma brucei unspecified product 0.0016 0.0028 0.0066
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2434 0.6705
Leishmania major glycosyl hydrolase-like protein 0.0015 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.01 0.0987 0.1627
Echinococcus granulosus importin subunit beta 1 0.0035 0.0243 0.0591
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.025 0.3716
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0017 0.004
Schistosoma mansoni 6-phosphofructokinase 0.0131 0.1349 0.3285
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0067 0.0606 0.1402
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0086 0.0211
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0257 0.0625
Echinococcus multilocularis lysine specific demethylase 6a 0.0019 0.0061 0.0061
Loa Loa (eye worm) 6-phosphofructokinase 0.0131 0.1349 0.2234
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0017 0.0044
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.031 0.0851
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0114
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.1152 0.2858
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0307 0.0841
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0103 0.0114
Onchocerca volvulus 0.0286 0.3124 0.5212
Plasmodium vivax importin-beta 2, putative 0.0035 0.0243 0.0532
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0061 0.0147
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0604 0.1497
Loa Loa (eye worm) hypothetical protein 0.0021 0.0079 0.0104
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0604 0.0604
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.056 0.1389
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0514 0.0833
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.031 0.0851
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2434 0.6705
Brugia malayi Muscleblind-like protein 0.0341 0.3753 0.6268
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1349 0.3714
Onchocerca volvulus 0.0042 0.0321 0.051
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0038 0.0283 0.0446
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0604 1
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0131 0.1349 0.2958
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.4026 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0257 0.0625
Mycobacterium ulcerans esterase/lipase LipP 0.0042 0.0321 0.0634
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0156 0.1635 0.4177
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0321 0.051
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0321 0.051
Schistosoma mansoni hypothetical protein 0.0058 0.0511 0.1245
Echinococcus multilocularis dna polymerase eta 0.0023 0.0111 0.0111
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0242 0.0588
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.1152 0.1903
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0086 0.0086
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0131 0.1349 0.3404
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0321 0.0782
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0257 0.3836
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0019 0.0061 0.0147
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.1152 0.1152
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0111 0.045
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0307 0.0485
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.0658 0.1602
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0257 0.0625
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.031 0.0851
Loa Loa (eye worm) runx1 0.0067 0.0613 0.0999
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0047 0.0114
Schistosoma mansoni apoptosis regulator bax 0.01 0.099 0.2411
Trypanosoma brucei unspecified product 0.0016 0.0028 0.0066
Mycobacterium tuberculosis Conserved protein 0.0042 0.0321 0.0634
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0345 0.3796 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0067 0.0606 0.0988
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Brugia malayi hypothetical protein 0.0182 0.1936 0.3219
Schistosoma mansoni hypothetical protein 0.01 0.099 0.2411
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4107 0.6861
Toxoplasma gondii exonuclease III APE 0.0021 0.0086 0.0804
Schistosoma mansoni hypothetical protein 0.0022 0.009 0.022
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0286 0.3118 0.5203
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0257 0.0257
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.3118 0.7594
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0321 0.0634
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0017 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0047 0.005
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1349 0.3714
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0167 0.0457
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0321 0.0782
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.031 0.0851
Brugia malayi Glycosyl hydrolases family 31 protein 0.0183 0.1946 0.3236
Schistosoma mansoni lipoxygenase 0.006 0.0535 0.1302
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0226 0.2434 0.6705
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0086 0.0211
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.031 0.1269
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.007 0.0642 0.1592
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0111 0.0157
Loa Loa (eye worm) hypothetical protein 0.0182 0.1936 0.3219
Echinococcus granulosus muscleblind protein 0.0341 0.3753 0.914
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0321 0.0795
Onchocerca volvulus 0.0036 0.0257 0.0402
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.099 0.1633
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0193 0.0353
Schistosoma mansoni survival motor neuron protein 0.0058 0.0511 0.1245
Brugia malayi beta-lactamase family protein 0.0042 0.0321 0.051
Echinococcus multilocularis snurportin 1 0.0372 0.4107 0.4107
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.1946 0.1946
Brugia malayi jmjC domain containing protein 0.0071 0.0658 0.1075
Echinococcus multilocularis Protein lozenge 0.0067 0.0613 0.0613
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0307 0.0758
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0604 0.1396
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0193 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.025 0.0686
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.025 0.0686
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0658 0.0658
Schistosoma mansoni hypothetical protein 0.0372 0.4107 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.009 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0487 0.0788
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4026 1
Toxoplasma gondii ABC1 family protein 0.0042 0.0321 0.4978
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0017 0.0044
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0042 0.0321 0.0634
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0193 0.0475
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.006 0.0535 0.0535
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.045 0.1097
Entamoeba histolytica hypothetical protein 0.0028 0.0167 0.0682
Leishmania major hypothetical protein, conserved 0.0042 0.0321 0.0795
Echinococcus granulosus lysosomal alpha glucosidase 0.0183 0.1946 0.4739
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0345 0.3796 1
Mycobacterium tuberculosis Conserved protein 0.0042 0.0321 0.0634
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.045 0.045
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0086 0.0234
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.031 0.0851
Trypanosoma cruzi hypothetical protein, conserved 0.007 0.0642 0.1592
Brugia malayi beta-lactamase 0.0042 0.0321 0.051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0017 0.004
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.1823 0.4526
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.025 0.0686
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0061 0.0061
Leishmania major DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0604 0.1396
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0226 0.2434 0.6705
Mycobacterium ulcerans 6-phosphofructokinase 0.0131 0.1349 0.3404
Schistosoma mansoni lipoxygenase 0.0022 0.009 0.022
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.031 0.0491
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1349 0.5539
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0321 0.0634
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.1152 0.1903
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0193 0.0475
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0077 0.0187
Leishmania major importin beta-1 subunit, putative 0.0028 0.0167 0.0412
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0067 0.0606 0.1476
Mycobacterium ulcerans glutaminase 0.033 0.3629 0.9552
Onchocerca volvulus 0.0022 0.009 0.0123
Plasmodium vivax SET domain protein, putative 0.0036 0.0257 0.0569
Echinococcus granulosus snurportin 1 0.0372 0.4107 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Loa Loa (eye worm) hypothetical protein 0.0019 0.0061 0.0073
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.1152 0.3171
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0111 0.027
Brugia malayi phosphofructokinase 0.0131 0.1349 0.2234
Echinococcus multilocularis phd:f box containing protein 0.0019 0.0061 0.0061
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.025 0.0507
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0061 0.0148
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.025 0.3716
Mycobacterium ulcerans hypothetical protein 0.0192 0.2047 0.5285
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0139 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0257 0.0257
Schistosoma mansoni alpha-glucosidase 0.0158 0.1653 0.4026
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.031 0.0491
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.051
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0307 0.0307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0491 0.135
Brugia malayi glutaminase DH11.1 0.033 0.3629 0.606
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.025 0.0686
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0307 0.0747
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0086 0.0211
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.099 0.2411
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0111 0.027
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.0987 0.4053
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0257 0.0625
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0111 0.0272
Mycobacterium ulcerans hypothetical protein 0.0042 0.0321 0.0634
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0111 0.0066
Giardia lamblia Kinase, PLK 0.0114 0.1152 0.4538
Mycobacterium ulcerans lipase LipD 0.0042 0.0321 0.0634
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0019 0.0061 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0321 0.0882
Entamoeba histolytica phosphofructokinase, putative 0.0131 0.1349 0.5539
Brugia malayi 6-phosphofructokinase 0.0131 0.1349 0.2234
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.1152 0.2804
Onchocerca volvulus 0.0226 0.2434 0.4055
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0321 0.0882
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.1823 0.4526
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0307 0.0747
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.1152 0.2804
Echinococcus granulosus 6 phosphofructokinase 0.0131 0.1349 0.3285
Onchocerca volvulus 0.0042 0.0321 0.051
Loa Loa (eye worm) phosphofructokinase 0.0131 0.1349 0.2234
Brugia malayi Pre-SET motif family protein 0.0251 0.2726 0.4544
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.031 0.0755
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.045 0.1097
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2726 0.4544
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0226 0.2434 0.633
Leishmania major hypothetical protein, conserved 0.0019 0.0061 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0307 0.0841
Loa Loa (eye worm) beta-lactamase 0.0042 0.0321 0.051
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.051
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0193 0.0398
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0131 0.1349 0.3404
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0028 0.0066
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0604 0.1471
Echinococcus granulosus arachidonate 5 lipoxygenase 0.006 0.0535 0.1302
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0111 0.0066
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.1152 0.1903
Echinococcus granulosus jumonji domain containing 1A 0.0019 0.0061 0.0148
Loa Loa (eye worm) jmjC domain-containing protein 0.0019 0.0061 0.0073
Schistosoma mansoni alpha-glucosidase 0.0158 0.1653 0.4026
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0017 0.0044
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0047 0.0047
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.2047 0.5285
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0345 0.3796 1
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.3118 0.3118
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0487 0.0788
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0042 0.0321 0.051
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0123
Schistosoma mansoni hypothetical protein 0.01 0.099 0.2411
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.0658 0.1602
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0283 0.0446
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.031 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0321 0.0795
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.009 0.022
Onchocerca volvulus 0.0106 0.106 0.1749
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0111 0.0066
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0226 0.2434 1
Onchocerca volvulus 0.0058 0.0511 0.0829
Schistosoma mansoni protein phosphatase 2C 0.0019 0.0061 0.0148
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0086 0.0116
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.0491 0.135
Brugia malayi beta-lactamase family protein 0.0042 0.0321 0.051
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0111 0.0272
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0193 0.2693
Onchocerca volvulus 0.0535 0.5978 1
Brugia malayi Pre-SET motif family protein 0.0036 0.0257 0.0402
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0321 0.0741
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1349 0.3714
Chlamydia trachomatis UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 0.0871 0.9835 1
Brugia malayi 6-phosphofructokinase 0.0131 0.1349 0.2234
Echinococcus granulosus phd:f box containing protein 0.0019 0.0061 0.0148
Schistosoma mansoni jumonji domain containing protein 0.0071 0.0658 0.1602
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0017 0.0044
Schistosoma mansoni alpha glucosidase 0.0041 0.031 0.0755
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0167 0.0457
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0307 0.0758
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.031 0.0767
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0111 0.0302
Echinococcus granulosus GPCR family 2 0.0018 0.0047 0.0114
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0067 0.0606 0.1402
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0604 0.1471
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.0658 0.1075
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.007 0.0642 0.1766
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0307 0.0747
Loa Loa (eye worm) hypothetical protein 0.0018 0.0047 0.005
Schistosoma mansoni loxhd1 0.0022 0.009 0.022
Loa Loa (eye worm) hypothetical protein 0.0022 0.009 0.0123
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.009 0.0126
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.099 0.1633
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0019 0.0061 0.0148
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0345 0.3796 1
Schistosoma mansoni lozenge 0.0067 0.0613 0.1493
Leishmania major hypothetical protein, conserved 0.007 0.0642 0.1592
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0432 0.1069
Echinococcus granulosus dna polymerase kappa 0.0023 0.0111 0.027
Onchocerca volvulus 0.0042 0.0321 0.051
Trichomonas vaginalis phosphofructokinase, putative 0.0131 0.1349 0.3714
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0086 0.021
Echinococcus multilocularis lysosomal alpha glucosidase 0.0183 0.1946 0.1946
Schistosoma mansoni hypothetical protein 0.0018 0.0047 0.0114
Mycobacterium tuberculosis Conserved protein 0.0042 0.0321 0.0634
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0167 0.0412
Trichomonas vaginalis glutaminase, putative 0.033 0.3629 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.025 0.0551

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 53 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 4.58 nM BindingDB_Patents: Enzyme Assay. IC50 determination in the LpxC enzyme assay was carried out in a similar manner to that described by Malikzay et al in the 2006 Poster, Screening LpxC (UDP-3-O(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using BioTrove Rapid Fire HTS Mass Spectrometry (aNew Lead Discovery and bInflammation and Infectious Disease, cStructural Chemistry, Schering-Plough Research Institute, Kenilworth, N.J. 07033, (BioTrove, Inc. 12 Gill St., Suite 4000, Woburn, Mass. 01801). Briefly, Pseudomonas aeruginosa LpxC enzyme (0.1 nM) purified from E. coli-overexpressing bacteria was incubated at 25° C. in a final volume of 50 ul containing 0.5 uM UDP-3-O(R-3-hydroxydecanoyl)-N-acetylglucosamine, 1 mg/mL BSA, and 50 mM sodium phosphate buffer, pH 8.0 in the presence and absence of inhibitor compound. At the end of 1 hour, 5 ul of 1N HCl was added to stop the enzyme reaction; the plates were centrifuged, and then processed with the BioTrove Rapidfire HTMS Mass Spectrometry System. ChEMBL. No reference
IC50 (binding) = 4.58 nM BindingDB_Patents: Enzyme Assay. IC50 determination in the LpxC enzyme assay was carried out in a similar manner to that described by Malikzay et al in the 2006 Poster, Screening LpxC (UDP-3-O(R-3-hydroxymyristoyl)-GlcNAc deacetylase) using BioTrove Rapid Fire HTS Mass Spectrometry (aNew Lead Discovery and bInflammation and Infectious Disease, cStructural Chemistry, Schering-Plough Research Institute, Kenilworth, N.J. 07033, (BioTrove, Inc. 12 Gill St., Suite 4000, Woburn, Mass. 01801). Briefly, Pseudomonas aeruginosa LpxC enzyme (0.1 nM) purified from E. coli-overexpressing bacteria was incubated at 25° C. in a final volume of 50 ul containing 0.5 uM UDP-3-O(R-3-hydroxydecanoyl)-N-acetylglucosamine, 1 mg/mL BSA, and 50 mM sodium phosphate buffer, pH 8.0 in the presence and absence of inhibitor compound. At the end of 1 hour, 5 ul of 1N HCl was added to stop the enzyme reaction; the plates were centrifuged, and then processed with the BioTrove Rapidfire HTMS Mass Spectrometry System. ChEMBL. No reference
IC50 (binding) = 2.89 uM PUBCHEM_BIOASSAY: uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. Inhibition of protein-protein interaction using fluorescence resonance energy transfer (FRET) assay Secondary Screen (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1438, AID1496, AID1502, AID1550, AID1560, AID1645] ChEMBL. No reference
IC50 (functional) = 3.745330827 um PUBCHEM_BIOASSAY: Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors. (Class of assay: confirmatory) [Related pubchem assays: 1022 (Primary screen preceding this dose-response assay.)] ChEMBL. No reference
IC50 (functional) 7.87 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 9.04 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 13.4 uM PUBCHEM_BIOASSAY: Identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a time resolved fluorescence resonance energy transfer (TR-FRET) assay. Counterscreen (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1434, AID1496, AID1502, AID1550, AID1560, AID1645] ChEMBL. No reference
IC50 (functional) 18.7 uM PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits from NadD in a Colorimetric assay - Set 2. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 80 uM PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0224 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.4125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 3.7933 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: Inhibitors of DNA Polymerase Beta: Hit validation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485311] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 37.933 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) = 63.0957 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 75.6863 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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